Jang-Ho J. Cha - Related publications

Affiliations: 
2015- Neurosciences Novartis Institutes for BioMedical Research, Cambridge, MA, United States 
Area:
Huntington's disease, drug discovery
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Xie M, Swanson MS. UTteR control through miRs: fine-tuning ATXN1 levels to prevent ataxia. Genes & Development. 34: 1107-1109. PMID 32873576 DOI: 10.1101/gad.343020.120   
2020 Kirtana R, Manna S, Patra SK. Molecular mechanisms of KDM5A in cellular functions: Facets during development and disease. Experimental Cell Research. 112314. PMID 33010254 DOI: 10.1016/j.yexcr.2020.112314   
2020 Kirtana R, Manna S, Patra SK. Molecular mechanisms of KDM5A in cellular functions: Facets during development and disease. Experimental Cell Research. 112314. PMID 33010254 DOI: 10.1016/j.yexcr.2020.112314   
2020 Nowak U, Janik S, Marchwicka A, Łaszkiewicz A, Jakuszak A, Cebrat M, Marcinkowska E. Investigating the Role of Methylation in Silencing of Gene Expression in Normal Cells during Hematopoiesis and in Their Leukemic Counterparts. Cells. 9. PMID 32872475 DOI: 10.3390/cells9091991   
2020 Han Z, Chen C, Christiansen A, Ji S, Lin Q, Anumonwo C, Liu C, Leiser SC, Meena, Aznarez I, Liau G, Isom LL. Antisense oligonucleotides increase expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Science Translational Medicine. 12. PMID 32848094 DOI: 10.1126/scitranslmed.aaz6100   
2020 Song P, Hong J, Wang Y, Yao X, Zhan Y, Yin R, Yu M, Li C, Yang X, Ge C. Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 32845162 DOI: 10.1139/bcb-2019-0279   
2020 Akintade D, Chaudhuri B. The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast. Bioscience Reports. PMID 32794578 DOI: 10.1042/BSR20201912   
2020 Yang F, Li L, Lin S. Methylation pattern and expression dynamics of methylase and photosystem genes under varied light intensities in Fugacium kawagutii (Symbiodiniaceae). Journal of Phycology. PMID 32920818 DOI: 10.1111/jpy.13070   
2020 Matharu N, Ahituv N. Modulating gene regulation to treat genetic disorders. Nature Reviews. Drug Discovery. PMID 33020616 DOI: 10.1038/s41573-020-0083-7   
2020 N'Diaye A, Byrns B, Cory AT, Nilsen KT, Walkowiak S, Sharpe A, Robinson SJ, Pozniak CJ. Machine learning analyses of methylation profiles uncovers tissue-specific gene expression patterns in wheat. The Plant Genome. 13: e20027. PMID 33016606 DOI: 10.1002/tpg2.20027   
2020 Leszczyński P, Śmiech M, Salam Teeli A, Haque E, Viger R, Ogawa H, Pierzchała M, Taniguchi H. Deletion of the Gene Causes a Neuronal Differentiation Deficiency in P19 Cells. International Journal of Molecular Sciences. 21. PMID 33003409 DOI: 10.3390/ijms21197192   
2020 Leszczyński P, Śmiech M, Salam Teeli A, Haque E, Viger R, Ogawa H, Pierzchała M, Taniguchi H. Deletion of the Gene Causes a Neuronal Differentiation Deficiency in P19 Cells. International Journal of Molecular Sciences. 21. PMID 33003409 DOI: 10.3390/ijms21197192   
2020 Fox S, Myers JA, Davidson C, Getman M, Kingsley PD, Frankiewicz N, Bulger M. Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function. Nature Communications. 11: 4544. PMID 32917861 DOI: 10.1038/s41467-020-18303-0   
2020 Hentrich T, Wassouf Z, Ehrhardt C, Haas E, Mills JD, Aronica E, Outeiro TF, Hübener-Schmid J, Riess O, Casadei N, Schulze-Hentrich JM. Increased expression of myelin-associated genes in frontal cortex of overexpressing rats and Parkinson's disease patients. Aging. 12. PMID 33017301 DOI: 10.18632/aging.103935   
2020 Freeman DM, Wang Z. Epigenetic Vulnerability of Insulator CTCF Motifs at Parkinson's Disease-Associated Genes in Response to Neurotoxicant Rotenone. Frontiers in Genetics. 11: 627. PMID 32774342 DOI: 10.3389/fgene.2020.00627   
2020 Shendy NAM, Raghu D, Roy S, Perry CH, Safi A, Branco MR, Homayouni R, Abell AN. Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching. Communications Biology. 3: 475. PMID 32859943 DOI: 10.1038/s42003-020-01200-z   
2020 Doshi A, Sadeghi F, Varadarajan N, Cirino PC. Small-molecule inducible transcriptional control in mammalian cells. Critical Reviews in Biotechnology. 1-20. PMID 32862714 DOI: 10.1080/07388551.2020.1808583   
2020 Guo X, Chen D, An S, Wang Z. ChIP-seq Profiling Identifies Histone Deacetylase 2 Targeting Genes Involved in Immune and Inflammatory Regulation Induced by Calcitonin Gene-Related Peptide in Microglial Cells. Journal of Immunology Research. 2020: 4384696. PMID 32832570 DOI: 10.1155/2020/4384696   
2020 Di Maria V, Moindrot M, Ryde M, Bono A, Quintino L, Ledri M. Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons. Frontiers in Molecular Neuroscience. 13: 168. PMID 33013319 DOI: 10.3389/fnmol.2020.00168   
2020 Li L, Li Y, Timothy Sembiring Meliala I, Kasim V, Wu S. Biological roles of Yin Yang 2: Its implications in physiological and pathological events. Journal of Cellular and Molecular Medicine. PMID 32969187 DOI: 10.1111/jcmm.15919   
2020 Tung KF, Pan CY, Chen CH, Lin WC. Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset. Scientific Reports. 10: 16245. PMID 33004865 DOI: 10.1038/s41598-020-73081-5   
2020 Dix C, Sgro S, Patel A, Perrotta C, Eldabagh N, Lomauro KL, Miguez FW, Chohan P, Jariwala C, Arnone JT. A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae. Journal of Visualized Experiments : Jove. PMID 33016939 DOI: 10.3791/61506   
2020 Ogushi S, Yoshida Y, Nakanishi T, Kimura T. CpG Site-Specific Regulation of Metallothionein-1 Gene Expression. International Journal of Molecular Sciences. 21. PMID 32824906 DOI: 10.3390/ijms21175946   
2020 Yeh HS, Yong J. mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights. Journal of Lipid and Atherosclerosis. 9: 8-22. PMID 32821719 DOI: 10.12997/jla.2020.9.1.8   
2020 Liang S, Ezerskyte M, Wang J, Pelechano V, Dreij K. Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape. Scientific Reports. 10: 13513. PMID 32782319 DOI: 10.1038/s41598-020-70412-4   
2020 Carullo NVN, Phillips Iii RA, Simon RC, Soto SAR, Hinds JE, Salisbury AJ, Revanna JS, Bunner KD, Ianov L, Sultan FA, Savell KE, Gersbach CA, Day JJ. Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems. Nucleic Acids Research. PMID 32810208 DOI: 10.1093/nar/gkaa671   
2020 Shi C, Jiang Y, Zhou T. Queuing Models of Gene Expression: Analytical Distributions and Beyond. Biophysical Journal. PMID 32966761 DOI: 10.1016/j.bpj.2020.09.001   
2020 Zhang X, Xiang Y, He D, Liang B, Wang C, Luo J, Zheng F. Identification of Potential Biomarkers for CAD Using Integrated Expression and Methylation Data. Frontiers in Genetics. 11: 778. PMID 33033488 DOI: 10.3389/fgene.2020.00778   
2020 Jasenosky LD, Nambu A, Tsytsykova AV, Ranjbar S, Haridas V, Kruidenier L, Tough DF, Goldfeld AE. Identification of a Distal Locus Enhancer Element That Controls Cell Type-Specific and Gene Expression in Human T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 32978279 DOI: 10.4049/jimmunol.1901311   
2020 Batra R, Gautam T, Pal S, Chaturvedi D, Rakhi, Jan I, Balyan HS, Gupta PK. Identification and characterization of SET domain family genes in bread wheat (Triticum aestivum L.). Scientific Reports. 10: 14624. PMID 32884064 DOI: 10.1038/s41598-020-71526-5   
2020 Yang J, McGovern A, Martin P, Duffus K, Ge X, Zarrineh P, Morris AP, Adamson A, Fraser P, Rattray M, Eyre S. Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis. Nature Communications. 11: 4402. PMID 32879318 DOI: 10.1038/s41467-020-18180-7   
2020 Bagnall J, Rowe W, Alachkar N, Roberts J, England H, Clark C, Platt M, Jackson DA, Muldoon M, Paszek P. Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling. Cell Systems. PMID 32918862 DOI: 10.1016/j.cels.2020.08.007   
2020 Chen K, Tang WS, Zhou YB, Xu ZS, Chen J, Ma YZ, Chen M, Li HY. Overexpression of GmUBC9 Gene Enhances Plant Drought Resistance and Affects Flowering Time Histone H2B Monoubiquitination. Frontiers in Plant Science. 11: 555794. PMID 33013972 DOI: 10.3389/fpls.2020.555794   
2020 Lv S, Guo H, Zhang M, Wang Q, Zhang H, Ji W. Large-Scale Cloning and Comparative Analysis of TaNAC Genes in Response to Stripe Rust and Powdery Mildew in Wheat ( L.). Genes. 11. PMID 32932603 DOI: 10.3390/genes11091073   
2020 Song S, Nguyen V, Schrank T, Mulvaney K, Walter V, Wei D, Orvis T, Desai N, Zhang J, Hayes DN, Zheng Y, Major MB, Weissman BE. Loss of SWI/SNF chromatin remodeling alters NRF2 signaling in non-small cell lung carcinoma. Molecular Cancer Research : McR. PMID 32855269 DOI: 10.1158/1541-7786.MCR-20-0082   
2020 Feng X, Zhu S, Yan Z, Wang C, Tong W, Xu W. PDGFRB as a potential therapeutic target of ankylosing spondylitis: validation following bioinformatics analysis. Cellular and Molecular Biology (Noisy-Le-Grand, France). 66: 127-134. PMID 33040798   
2020 Sánchez-Romero MA, Olivenza DR, Gutiérrez G, Casadesús J. Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica. Nucleic Acids Research. PMID 32954419 DOI: 10.1093/nar/gkaa730   
2020 Sun LM, Fang JB, Zhang M, Qi XJ, Lin MM, Chen JY. Molecular Cloning and Functional Analysis of the Homolog in Kiwifruit (). Frontiers in Plant Science. 11: 551201. PMID 33042179 DOI: 10.3389/fpls.2020.551201   
2020 Macharia TN, Bellieny-Rabelo D, Moleleki LN. Transcriptome Profiling of Potato ( L.) Responses to Root-Knot Nematode () Infestation during A Compatible Interaction. Microorganisms. 8. PMID 32967109 DOI: 10.3390/microorganisms8091443   
2020 Chung YS, Jin HL, Jeong KW. Cell-specific expression of gene by FOXA1 in the glucocorticoid receptor pathway. International Journal of Immunopathology and Pharmacology. 34: 2058738420946192. PMID 32838581 DOI: 10.1177/2058738420946192   
2020 Sozoniuk M, Parzymies M, Kozak D, Ismael BS. and Osmotic Stress: Identification of Reference Genes for Transcriptional Profiling by RT-qPCR. Genes. 11. PMID 32878033 DOI: 10.3390/genes11091022   
2020 Li J, Durose WW, Ito J, Kakita A, Iguchi Y, Katsuno M, Kunisawa K, Shimizu T, Ikenaka K. Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. Journal of Neurochemistry. PMID 32947653 DOI: 10.1111/jnc.15190   
2020 Soules KR, LaBrie SD, May BH, Hefty PS. Sigma 54-Regulated Transcription Is Associated with Membrane Reorganization and Type III Secretion Effectors during Conversion to Infectious Forms of Chlamydia trachomatis. Mbio. 11. PMID 32900805 DOI: 10.1128/mBio.01725-20   
2020 Xu Z, Li Y. A MarR-family transcriptional factor MapR positively regulates actinorhodin production in Streptomyces coelicolor. Fems Microbiology Letters. PMID 32821931 DOI: 10.1093/femsle/fnaa140   
2020 Han Q, Guo X, Jia K, Jing J, Dang W, Li Y, Qin X, Li P, Ren Y, Liu W, Kebreab E, Lyu L. Effects of FOXO1 on the proliferation and cell cycle-, apoptosis- and steroidogenesis-related genes expression in sheep granulosa cells. Animal Reproduction Science. 221: 106604. PMID 32980650 DOI: 10.1016/j.anireprosci.2020.106604   
2020 Backstrom JR, Sheng J, Wang MC, Bernardo-Colón A, Rex TS. Optimization of dCas9 and CRISPRi Elements for a Single Adeno-Associated Virus that Targets an Endogenous Gene. Molecular Therapy. Methods & Clinical Development. 19: 139-148. PMID 33024795 DOI: 10.1016/j.omtm.2020.09.001   
2020 Zhang D, Guelfi S, Garcia-Ruiz S, Costa B, Reynolds RH, D'Sa K, Liu W, Courtin T, Peterson A, Jaffe AE, Hardy J, Botía JA, Collado-Torres L, Ryten M. Incomplete annotation has a disproportionate impact on our understanding of Mendelian and complex neurogenetic disorders. Science Advances. 6. PMID 32917675 DOI: 10.1126/sciadv.aay8299   
2020 Peng L, Li EM, Xu LY. From start to end: phase separation and transcriptional regulation. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194641. PMID 33017669 DOI: 10.1016/j.bbagrm.2020.194641   
2020 Gu L, Ni J, Sheng S, Zhao K, Sun C, Wang J. Microarray analysis of long non-coding RNA expression profiles in Marfan syndrome. Experimental and Therapeutic Medicine. 20: 3615-3624. PMID 32855713 DOI: 10.3892/etm.2020.9093   
2020 Zhou DY, Mou X, Liu K, Liu WH, Xu YQ, Zhou D. prediction and validation of potential therapeutic genes in pancreatic β-cells associated with type 2 diabetes. Experimental and Therapeutic Medicine. 20: 60. PMID 32952650 DOI: 10.3892/etm.2020.9188