Andrew Singleton, PhD - Publications

Affiliations: 
Neurogenetics National Institute of Aging, Cabanatuan City, Central Luzon, Philippines 
Area:
http://www.biomedexperts.com/Profile.bme/1999112/Andrew_Singleton
Website:
http://neuroscience.nih.gov/Lab.asp?Org_ID=454

385 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, ... ... Singleton AB, et al. Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30957308 DOI: 10.1002/mds.27659  1
2019 Hammer M, Abravanel A, Peckham E, Mahloogi A, Majounie E, Hallett M, Singleton A. Blepharospasm: A genetic screening study in 132 patients. Parkinsonism & Related Disorders. PMID 30956059 DOI: 10.1016/j.parkreldis.2019.04.003  0.68
2019 Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... ... Singleton A, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/j.nbd.2019.04.004  1
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Singleton AB, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.44
2019 Bandres-Ciga S, Noyce AJ, Hemani G, Nicolas A, Calvo A, Mora G, Tienari PJ, Stone DJ, Nalls MA, Singleton AB, Chiò A, Traynor BJ. Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. Annals of Neurology. PMID 30723964 DOI: 10.1002/ana.25431  1
2019 Driscoll I, Snively BM, Espeland MA, Shumaker SA, Rapp SR, Goveas JS, Casanova RL, Wactawski-Wende J, Manson JE, Rossom R, Brooks J, Hernandez DG, Singleton AB, Resnick SM. A candidate gene study of risk for dementia in older, post-menopausal women: Results from the Women's Health Initiative Memory Study. International Journal of Geriatric Psychiatry. PMID 30706571 DOI: 10.1002/gps.5068  0.52
2019 Bandres-Ciga S, Saez-Atienzar S, Bonet-Ponce L, Billingsley K, Vitale D, Blauwendraat C, Gibbs JR, Pihlstrøm L, Gan-Or Z, Cookson MR, Nalls MA, Singleton AB. The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30675927 DOI: 10.1002/mds.27614  1
2018 Ward-Caviness CK, Agha G, Chen BH, Pfeiffer L, Wilson R, Wolf P, Gieger C, Schwartz J, Vokonas PS, Hou L, Just AC, Bandinelli S, Hernandez DG, Singleton AB, Prokisch H, et al. Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction. Clinical Epigenetics. 10: 161. PMID 30587240 DOI: 10.1186/s13148-018-0588-7  0.52
2018 Kristiansen M, Maple-Grødem J, Alves G, Arepalli S, Hernandez DG, Iwaki H, Nalls MA, Singleton A, Tysnes OB, Toft M, Pihlstrøm L. A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30484896 DOI: 10.1002/mds.27555  0.68
2018 Guven G, Bilgic B, Tufekcioglu Z, Erginel Unaltuna N, Hanagasi H, Gurvit H, Singleton A, Hardy J, Emre M, Gulec C, Bras J, Guerreiro R, Lohmann E. Peripheral GRN mRNA and Serum Progranulin Levels as a Potential Indicator for Both the Presence of Splice Site Mutations and Individuals at Risk for Frontotemporal Dementia. Journal of Alzheimer's Disease : Jad. PMID 30475763 DOI: 10.3233/JAD-180599  1
2018 Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, ... ... Singleton A, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/j.neurobiolaging.2018.10.019  1
2018 Blauwendraat C, Bras JM, Nalls MA, Lewis PA, Hernandez DG, Singleton AB. Coding variation in GBA explains the majority of the SYT11-GBA Parkinson's disease GWAS locus. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30302829 DOI: 10.1002/mds.103  0.68
2018 Zhang M, Ferrari R, Tartaglia MC, Keith J, Surace EI, Wolf U, Sato C, Grinberg M, Liang Y, Xi Z, Dupont K, McGoldrick P, Weichert A, McKeever PM, Schneider R, ... ... Singleton A, et al. A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers. Brain : a Journal of Neurology. PMID 30252044 DOI: 10.1093/brain/awy238  1
2018 Pihlstrøm L, Blauwendraat C, Cappelletti C, Berge-Seidl V, Langmyhr M, Henriksen SP, van de Berg WDJ, Gibbs JR, Cookson MR, Singleton AB, Nalls MA, Toft M. A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease. Annals of Neurology. PMID 30146727 DOI: 10.1002/ana.25274  1
2018 Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, ... ... Singleton A, et al. Finding useful biomarkers for Parkinson's disease. Science Translational Medicine. 10. PMID 30111645 DOI: 10.1126/scitranslmed.aam6003  1
2018 Kia DA, Noyce AJ, White J, Speed D, Nicolas A, Burgess S, Lawlor DA, Davey Smith G, Singleton A, Nalls MA, Sofat R, Wood NW. Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease. Annals of Neurology. PMID 30014513 DOI: 10.1002/ana.25294  0.68
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Singleton AB, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/j.neuron.2018.02.027  1
2018 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J, Blumenau S, ... ... Singleton AB, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging. PMID 29544907 DOI: 10.1016/j.neurobiolaging.2018.01.015  1
2018 Burciu RG, Seidler RD, Shukla P, Nalls MA, Singleton AB, Okun MS, Vaillancourt DE. Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults. Neurobiology of Aging. 66: 32-39. PMID 29505953 DOI: 10.1016/j.neurobiolaging.2018.02.001  0.68
2018 Coutelier M, Hammer MB, Stevanin G, Monin ML, Davoine CS, Mochel F, Labauge P, Ewenczyk C, Ding J, Gibbs JR, Hannequin D, Melki J, Toutain A, Laugel V, Forlani S, ... ... Singleton A, et al. Efficacy of Exome-Targeted Capture Sequencing to Detect Mutations in Known Cerebellar Ataxia Genes. Jama Neurology. PMID 29482223 DOI: 10.1001/jamaneurol.2017.5121  0.84
2018 Mäkelä M, Kaivola K, Valori M, Paetau A, Polvikoski T, Singleton AB, Traynor BJ, Stone DJ, Peuralinna T, Tienari PJ, Tanskanen M, Myllykangas L. Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+). Neurology. Genetics. 4: e211. PMID 29379882 DOI: 10.1212/NXG.0000000000000211  1
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Singleton A, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/s13073-018-0516-7  1
2018 Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai PC, Vojinovic D, Simino J, Levy D, Liu C, Mendelson M, ... ... Singleton AB, et al. Meta-analysis of epigenome-wide association studies of cognitive abilities. Molecular Psychiatry. PMID 29311653 DOI: 10.1038/s41380-017-0008-y  0.52
2018 Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, ... ... Singleton A, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3  1
2017 Blauwendraat C, Kia DA, Pihlstrøm L, Gan-Or Z, Lesage S, Gibbs JR, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Chung SJ, Goldwurm S, Toft M, ... ... Singleton AB, et al. Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease. Neurobiology of Aging. PMID 29398121 DOI: 10.1016/j.neurobiolaging.2017.12.012  0.84
2017 Roosen DA, Singleton AB. Leucine rich repeat kinase knockout (LRRK KO) mouse model: Linking pathological hallmarks of inherited and sporadic Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29265552 DOI: 10.1002/mds.27267  0.32
2017 Dillman AA, Majounie E, Ding J, Gibbs JR, Hernandez D, Arepalli S, Traynor BJ, Singleton AB, Galter D, Cookson MR. Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging. Scientific Reports. 7: 16890. PMID 29203886 DOI: 10.1038/s41598-017-17322-0  1
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Singleton A, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/s13073-017-0486-1  1
2017 Patel T, Brookes KJ, Turton J, Chaudhury S, Guetta-Baranes T, Guerreiro R, Bras J, Hernandez D, Singleton A, Francis PT, Hardy J, Morgan K. Whole-exome sequencing of the BDR cohort: Evidence to support the role of the PILRA gene in Alzheimer's disease. Neuropathology and Applied Neurobiology. PMID 29181857 DOI: 10.1111/nan.12452  1
2017 Chaudhury S, Patel T, Barber IS, Guetta-Baranes T, Brookes KJ, Chappell S, Turton J, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann D, Morgan K. Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease. Neurobiology of Aging. PMID 29103623 DOI: 10.1016/j.neurobiolaging.2017.09.035  1
2017 Bettencourt C, Salpietro V, Efthymiou S, Chelban V, Hughes D, Pittman AM, Federoff M, Bourinaris T, Spilioti M, Deretzi G, Kalantzakou T, Houlden H, Singleton AB, Xiromerisiou G. Genotype-phenotype correlations and expansion of the molecular spectrum of AP4M1-related hereditary spastic paraplegia. Orphanet Journal of Rare Diseases. 12: 172. PMID 29096665 DOI: 10.1186/s13023-017-0721-2  0.76
2017 Manole A, Jaunmuktane Z, Hargreaves I, Ludtmann MHR, Salpietro V, Bello OD, Pope S, Pandraud A, Horga A, Scalco RS, Li A, Ashokkumar B, Lourenço CM, Heales S, Horvath R, ... ... Singleton AB, et al. Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. Brain : a Journal of Neurology. PMID 29053833 DOI: 10.1093/brain/awx231  0.76
2017 Ylönen S, Siitonen A, Nalls MA, Ylikotila P, Autere J, Eerola-Rautio J, Gibbs R, Hiltunen M, Tienari PJ, Soininen H, Singleton AB, Majamaa K. Genetic risk factors in Finnish patients with Parkinson's disease. Parkinsonism & Related Disorders. PMID 29029963 DOI: 10.1016/j.parkreldis.2017.09.021  0.68
2017 Chang D, Nalls MA, Hallgrímsdóttir IB, Hunkapiller J, van der Brug M, Cai F, Kerchner GA, Ayalon G, Bingol B, Sheng M, Hinds D, Behrens TW, Singleton AB, et al. A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. Nature Genetics. PMID 28892059 DOI: 10.1038/ng.3955  0.68
2017 Jansen IE, Gibbs JR, Nalls MA, Price TR, Lubbe S, van Rooij J, Uitterlinden AG, Kraaij R, Williams NM, Brice A, Hardy J, Wood NW, Morris HR, Gasser T, Singleton AB, et al. Establishing the role of rare coding variants in known Parkinson's disease risk loci. Neurobiology of Aging. PMID 28867149 DOI: 10.1016/j.neurobiolaging.2017.07.009  1
2017 Darwent L, Carmona S, Lohmann E, Guven G, Kun-Rodrigues C, Bilgic B, Hanagasi H, Gurvit H, Erginel-Unaltuna N, Pak M, Hardy J, Singleton A, Brás J, Guerreiro R. Mutations in TYROBP are not a common cause of dementia in a Turkish cohort. Neurobiology of Aging. PMID 28716534 DOI: 10.1016/j.neurobiolaging.2017.06.019  1
2017 Noyce AJ, Kia DA, Hemani G, Nicolas A, Price TR, De Pablo-Fernandez E, Haycock PC, Lewis PA, Foltynie T, Davey Smith G, Schrag A, Lees AJ, Hardy J, Singleton A, et al. Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. Plos Medicine. 14: e1002314. PMID 28609445 DOI: 10.1371/journal.pmed.1002314  1
2017 Blauwendraat C, Faghri F, Pihlstrom L, Geiger JT, Elbaz A, Lesage S, Corvol JC, May P, Nicolas A, Abramzon Y, Murphy NA, Gibbs JR, Ryten M, Ferrari R, Bras J, ... ... Singleton AB, et al. NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases. Neurobiology of Aging. PMID 28602509 DOI: 10.1016/j.neurobiolaging.2017.05.009  1
2017 Larsson SC, Singleton AB, Nalls MA, Richards JB. No clear support for a role for vitamin D in Parkinson's disease: A Mendelian randomization study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28594127 DOI: 10.1002/mds.27069  0.68
2017 McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, ... ... Singleton A, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. PMID 28592453 DOI: 10.1212/WNL.0000000000004058  0.68
2017 Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG, Djurovic S, Schork AJ, Bettella F, Ellinghaus D, Franke A, Lie BA, McEvoy LK, ... ... Singleton AB, et al. Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. Jama Neurology. PMID 28586827 DOI: 10.1001/jamaneurol.2017.0469  1
2017 Hammer MB, Ding J, Mochel F, Eleuch-Fayache G, Charles P, Coutelier M, Gibbs JR, Arepalli SK, Chong SB, Hernandez DG, Majounie E, Clipman S, Bouhlal Y, Nehdi H, Brice A, ... ... Singleton AB, et al. SLC25A46 Mutations Associated with Autosomal Recessive Cerebellar Ataxia in North African Families. Neuro-Degenerative Diseases. 17: 208-212. PMID 28558379 DOI: 10.1159/000464445  0.84
2017 Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, ... ... Singleton A, et al. NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. Journal of the American Society of Nephrology : Jasn. PMID 28360221 DOI: 10.1681/ASN.2016080892  0.68
2017 Singleton AB, Hardy JA, Gasser T. The Birth of the Modern Era of Parkinson's Disease Genetics. Journal of Parkinson's Disease. 7: S89-S95. PMID 28282818 DOI: 10.3233/JPD-179009  0.64
2017 Capozzo R, Sassi C, Hammer MB, Arcuti S, Zecca C, Barulli MR, Tortelli R, Gibbs JR, Crews C, Seripa D, Carnicella F, Dell'Aquila C, Rossi M, Tamma F, Valluzzi F, ... ... Singleton AB, et al. Clinical and genetic analyses of familial and sporadic frontotemporal dementia patients in Southern Italy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28264768 DOI: 10.1016/j.jalz.2017.01.011  0.88
2017 Siitonen A, Nalls MA, Hernández D, Gibbs JR, Ding J, Ylikotila P, Edsall C, Singleton A, Majamaa K. Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study. Neurobiology of Aging. PMID 28256260 DOI: 10.1016/j.neurobiolaging.2017.01.019  0.84
2017 Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, Lubbe SJ, Drouet V, Lesage S, Majounie E, Gibbs JR, Nalls MA, Ryten M, Botia JA, Vandrovcova J, ... ... Singleton AB, et al. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology. 18: 22. PMID 28137300 DOI: 10.1186/s13059-017-1147-9  0.84
2017 Ferrari R, Grassi M, Graziano F, Palluzzi F, Archetti S, Bonomi E, Bruni AC, Maletta RG, Bernardi L, Cupidi C, Colao R, Rainero I, Rubino E, Pinessi L, Galimberti D, ... ... Singleton A, et al. Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia. Journal of Alzheimer's Disease : Jad. PMID 28128768 DOI: 10.3233/JAD-160949  1
2017 Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, ... ... Singleton A, et al. Novel genetic loci associated with hippocampal volume. Nature Communications. 8: 13624. PMID 28098162 DOI: 10.1038/ncomms13624  0.84
2016 Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Mägi R, DeMeo D, O'Connor GT, Ferrucci L, Teumer A, Homuth G, Biffar R, Völker U, Herder C, ... ... Singleton AB, et al. A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. Human Molecular Genetics. 25: 4611-4623. PMID 28158590 DOI: 10.1093/hmg/ddw288  0.52
2016 Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, ... ... Singleton AB, et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biology. 17: 255. PMID 27955697 DOI: 10.1186/s13059-016-1119-5  0.52
2016 Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiology of Aging. PMID 27939698 DOI: 10.1016/j.neurobiolaging.2016.11.007  0.68
2016 Dong J, Wyss A, Yang J, Price TR, Nicolas A, Nalls M, Tranah G, Franceschini N, Xu Z, Schulte C, Alonso A, Cummings SR, Fornage M, Zaykin D, Li L, ... ... Singleton AB, et al. Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. Molecular Neurobiology. PMID 27878761 DOI: 10.1007/s12035-016-0282-8  0.64
2016 Lubbe SJ, Escott-Price V, Gibbs JR, Nalls MA, Bras J, Price TR, Nicolas A, Jansen IE, Mok KY, Pittman AM, Tomkins JE, Lewis PA, Noyce AJ, Lesage S, Sharma M, ... ... Singleton AB, et al. Additional Rare Variant Analysis in Parkinson's Disease Cases with and Without Known Pathogenic Mutations: Evidence for Oligogenic Inheritance. Human Molecular Genetics. PMID 27798102 DOI: 10.1093/hmg/ddw348  1
2016 Barber IS, Braae A, Clement N, Patel T, Guetta-Baranes T, Brookes K, Medway C, Chappell S, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann DM, et al. Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array. Neurobiology of Aging. PMID 27776828 DOI: 10.1016/j.neurobiolaging.2016.09.008  1
2016 Hopfner F, Haubenberger D, Galpern WR, Gwinn K, Van't Veer A, White S, Bhatia K, Adler CH, Eidelberg D, Ondo W, Stebbins GT, Tanner CM, Helmich RC, Lenz FA, Sillitoe RV, ... ... Singleton A, et al. Knowledge gaps and research recommendations for essential tremor. Parkinsonism & Related Disorders. PMID 27769649 DOI: 10.1016/j.parkreldis.2016.10.002  0.4
2016 Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, ... ... Singleton A, et al. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience. PMID 27694991 DOI: 10.1038/nn.4398  1
2016 Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, ... ... Singleton AB, et al. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging. PMID 27690265 DOI: 10.18632/aging.101020  0.52
2016 Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, ... ... Singleton A, et al. Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of Aging. PMID 27666590 DOI: 10.1016/j.neurobiolaging.2016.08.023  0.92
2016 Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, ... ... Singleton AB, et al. Epigenetic Signatures of Cigarette Smoking. Circulation. Cardiovascular Genetics. PMID 27651444 DOI: 10.1161/CIRCGENETICS.116.001506  0.52
2016 Guven G, Lohmann E, Bras J, Gibbs JR, Gurvit H, Bilgic B, Hanagasi H, Rizzu P, Heutink P, Emre M, Erginel-Unaltuna N, Just W, Hardy J, Singleton A, Guerreiro R. Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients. Plos One. 11: e0162592. PMID 27632209 DOI: 10.1371/journal.pone.0162592  1
2016 Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, ... ... Singleton AB, et al. A genome-wide association study in multiple system atrophy. Neurology. PMID 27629089 DOI: 10.1212/WNL.0000000000003221  1
2016 Chen BH, Hivert MF, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, Hernandez DG, Hofman A, Hong J, Joehanes R, Johnson AD, ... ... Singleton AB, et al. Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes. PMID 27625022 DOI: 10.2337/db16-0470  0.52
2016 Gang Q, Bettencourt C, Machado PM, Brady S, Holton JL, Pittman AM, Hughes D, Healy E, Parton M, Hilton-Jones D, Shieh PB, Needham M, Liang C, Zanoteli E, de Camargo LV, ... ... Singleton AB, et al. Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis. Neurobiology of Aging. PMID 27594680 DOI: 10.1016/j.neurobiolaging.2016.07.024  0.76
2016 Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Mägi R, DeMeo D, O'Connor GT, Ferrucci L, Teumer A, Homuth G, Biffar R, Völker U, Herder C, ... ... Singleton AB, et al. A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics. PMID 27577875 DOI: 10.1093/hmg/ddw288  0.52
2016 Evans DS, Avery CL, Nalls MA, Li G, Barnard J, Smith EN, Tanaka T, Butler AM, Buxbaum SG, Alonso A, Arking DE, Berenson GS, Bis JC, Buyske S, Carty CL, ... ... Singleton AB, et al. Fine-mapping, Novel Loci Identification, and SNP Association Transferability in a Genome-Wide Association Study of QRS Duration in African Americans. Human Molecular Genetics. PMID 27577874 DOI: 10.1093/hmg/ddw284  0.68
2016 Bras J, Djaldetti R, Alves AM, Mead S, Darwent L, Lleo A, Molinuevo JL, Blesa R, Singleton A, Hardy J, Clarimon J, Guerreiro R. Exome sequencing in a consanguineous family clinically diagnosed with early-onset Alzheimer's disease identifies a homozygous CTSF mutation. Neurobiology of Aging. PMID 27524508 DOI: 10.1016/j.neurobiolaging.2016.06.018  1
2016 Levine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, Bandinelli S, Salfati E, Manson JE, Quach A, Kusters CD, Kuh D, Wong A, Teschendorff AE, Widschwendter M, et al. Menopause accelerates biological aging. Proceedings of the National Academy of Sciences of the United States of America. PMID 27457926 DOI: 10.1073/pnas.1604558113  0.52
2016 Bandrés-Ciga S, Price TR, Barrero FJ, Escamilla-Sevilla F, Pelegrina J, Arepalli S, Hernández D, Gutiérrez B, Cervilla J, Rivera M, Rivera A, Ding JH, Vives F, Nalls M, Singleton A, et al. Genome-wide assessment of Parkinson's disease in a Southern Spanish population. Neurobiology of Aging. PMID 27393345 DOI: 10.1016/j.neurobiolaging.2016.06.001  0.48
2016 Mehta SH, Dickson DW, Morgan JC, Singleton AB, Majounie E, Sethi KD. Juvenile onset Parkinsonism with "pure nigral" degeneration and POLG1 mutation. Parkinsonism & Related Disorders. PMID 27349602 DOI: 10.1016/j.parkreldis.2016.06.013  0.68
2016 Wang Y, Hersheson J, Lopez D, Hammer M, Liu Y, Lee KH, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, et al. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell Reports. PMID 27320912 DOI: 10.1016/j.celrep.2016.05.044  0.76
2016 Geiger JT, Ding J, Crain B, Pletnikova O, Letson C, Dawson TM, Rosenthal LS, Pantelyat A, Gibbs JR, Albert MS, Hernandez DG, Hillis AE, Stone DJ, Singleton AB, et al. Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies. Neurobiology of Disease. PMID 27312774 DOI: 10.1016/j.nbd.2016.06.004  1
2016 Singleton A, Hardy J. The Evolution of Genetics: Alzheimer's and Parkinson's Diseases. Neuron. 90: 1154-63. PMID 27311081 DOI: 10.1016/j.neuron.2016.05.040  1
2016 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, ... ... Singleton AB, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiology of Aging. PMID 27289440 DOI: 10.1016/j.neurobiolaging.2016.04.004  1
2016 Blauwendraat C, Francescatto M, Gibbs JR, Jansen IE, Simón-Sánchez J, Hernandez DG, Dillman AA, Singleton AB, Cookson MR, Rizzu P, Heutink P. Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe. Genome Medicine. 8: 65. PMID 27287230 DOI: 10.1186/s13073-016-0320-1  1
2016 Sassi C, Capozzo R, Gibbs R, Crews C, Zecca C, Arcuti S, Copetti M, Barulli MR, Brescia V, Singleton AB, Logroscino G. A Novel Splice-Acceptor Site Mutation in GRN (c.709-2 A>T) Causes Frontotemporal Dementia Spectrum in a Large Family from Southern Italy. Journal of Alzheimer's Disease : Jad. PMID 27258413 DOI: 10.3233/JAD-151170  0.88
2016 Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Morgan K, ... ... Singleton AB, et al. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. Plos One. 11: e0150079. PMID 27249223 DOI: 10.1371/journal.pone.0150079  1
2016 Kara E, Tucci A, Manzoni C, Lynch DS, Elpidorou M, Bettencourt C, Chelban V, Manole A, Hamed SA, Haridy NA, Federoff M, Preza E, Hughes D, Pittman A, Jaunmuktane Z, ... ... Singleton AB, et al. Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain : a Journal of Neurology. PMID 27217339 DOI: 10.1093/brain/aww111  1
2016 Hernandez DG, Reed X, Singleton AB. Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance. Journal of Neurochemistry. PMID 27090875 DOI: 10.1111/jnc.13593  1
2016 Kraemmer J, Smith K, Weintraub D, Guillemot V, Nalls MA, Cormier-Dequaire F, Moszer I, Brice A, Singleton AB, Corvol JC. Clinical-genetic model predicts incident impulse control disorders in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27076492 DOI: 10.1136/jnnp-2015-312848  1
2016 Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligórska T, Taylor P, Shah N, Pan S, Zero P, ... ... Singleton A, et al. CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathologica. PMID 27021906 DOI: 10.1007/s00401-016-1552-2  1
2016 Mok KY, Sheerin U, Simón-Sánchez J, Salaka A, Chester L, Escott-Price V, Mantripragada K, Doherty KM, Noyce AJ, Mencacci NE, Lubbe SJ, Williams-Gray CH, Barker RA, van Dijk KD, ... ... Singleton AB, et al. Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data. The Lancet. Neurology. PMID 27017469 DOI: 10.1016/S1474-4422(16)00071-5  1
2016 Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, ... ... Singleton A, et al. Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy. American Journal of Human Genetics. 98: 500-13. PMID 26942284 DOI: 10.1016/j.ajhg.2016.01.014  1
2015 Lesage S, Bras J, Cormier-Dequaire F, Condroyer C, Nicolas A, Darwent L, Guerreiro R, Majounie E, Federoff M, Heutink P, Wood NW, Gasser T, Hardy J, Tison F, Singleton A, et al. Loss-of-function mutations in RAB39B are associated with typical early-onset Parkinson disease. Neurology. Genetics. 1: e9. PMID 27066548 DOI: 10.1212/NXG.0000000000000009  1
2015 Barber IS, García-Cárdenas JM, Sakdapanichkul C, Deacon C, Zapata Erazo G, Guerreiro R, Bras J, Hernandez D, Singleton A, Guetta-Baranes T, Braae A, Clement N, Patel T, Brookes K, Medway C, et al. Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease. Neurobiology of Aging. PMID 26803359 DOI: 10.1016/j.neurobiolaging.2015.12.011  0.92
2015 Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, ... ... Singleton A, et al. Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging. PMID 26643944 DOI: 10.1016/j.neurobiolaging.2015.10.028  1
2015 Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Frontiers in Neurology. 6: 237. PMID 26617567 DOI: 10.3389/fneur.2015.00237  0.68
2015 Federoff M, Price TR, Sailer A, Scholz S, Hernandez D, Nicolas A, Singleton AB, Nalls M, Houlden H. Genome-wide estimate of the heritability of Multiple System Atrophy. Parkinsonism & Related Disorders. PMID 26589003 DOI: 10.1016/j.parkreldis.2015.11.005  0.76
2015 Mou Z, Hyde TM, Lipska BK, Martinowich K, Wei P, Ong CJ, Hunter LA, Palaguachi GI, Morgun E, Teng R, Lai C, Condarco TA, Demidowich AP, Krause AJ, Marshall LJ, ... ... Singleton AB, et al. Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. Cell Reports. PMID 26526993 DOI: 10.1016/j.celrep.2015.09.065  0.68
2015 Pilling LC, Joehanes R, Kacprowski T, Peters MJ, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell JE, Levy D, Lin H, Lunetta K, Munson PJ, Bandinelli S, ... ... Singleton AB, et al. Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiological Genomics. physiolgenomics.0005. PMID 26487704 DOI: 10.1152/physiolgenomics.00054.2015  0.48
2015 Peuralinna T, Myllykangas L, Oinas M, Nalls MA, Keage HA, Isoviita VM, Valori M, Polvikoski T, Paetau A, Sulkava R, Ince PG, Zaccai J, Brayne C, Traynor BJ, Hardy J, ... Singleton AB, et al. Genome-wide association study of neocortical Lewy-related pathology. Annals of Clinical and Translational Neurology. 2: 920-31. PMID 26401513 DOI: 10.1002/acn3.231  1
2015 Lubbe SJ, Escott-Price V, Brice A, Gasser T, Hardy J, Heutink P, Sharma M, Wood NW, Nalls M, Singleton AB, Williams NM, Morris HR. Is the MC1R variant p.R160W associated with Parkinson's? Annals of Neurology. PMID 26389967 DOI: 10.1002/ana.24527  1
2015 van der Brug MP, Singleton A, Gasser T, Lewis PA. Parkinson's disease: From human genetics to clinical trials. Science Translational Medicine. 7: 205ps20. PMID 26378242 DOI: 10.1126/scitranslmed.aaa8280  1
2015 Kun-Rodrigues C, Ganos C, Guerreiro R, Schneider SA, Schulte C, Lesage S, Darwent L, Holmans P, Singleton A, Bhatia K, Bras J. A systematic screening to identify de novo mutations causing sporadic early-onset Parkinson's disease. Human Molecular Genetics. PMID 26362251 DOI: 10.1093/hmg/ddv376  0.92
2015 Moore AZ, Hernandez DG, Tanaka T, Pilling LC, Nalls MA, Bandinelli S, Singleton AB, Ferrucci L. Change in Epigenome-Wide DNA Methylation Over 9 Years and Subsequent Mortality: Results From the InCHIANTI Study. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26355017 DOI: 10.1093/gerona/glv118  0.68
2015 Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, ... ... Singleton AB, et al. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. The Lancet. Neurology. 14: 1002-9. PMID 26271532 DOI: 10.1016/S1474-4422(15)00178-7  1
2015 Nalls MA, Keller MF, Hernandez DG, Chen L, Stone DJ, Singleton AB. Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI). Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26268663 DOI: 10.1002/mds.26374  1
2015 Ferrari R, Grassi M, Salvi E, Borroni B, Palluzzi F, Pepe D, D'Avila F, Padovani A, Archetti S, Rainero I, Rubino E, Pinessi L, Benussi L, Binetti G, Ghidoni R, ... ... Singleton A, et al. A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia. Neurobiology of Aging. 36: 2904.e13-26. PMID 26154020 DOI: 10.1016/j.neurobiolaging.2015.06.005  1
2015 Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying SX, Lunetta KL, Benjamin EJ, Singleton A, Levy D, Munson P, et al. Gene expression markers of age-related inflammation in two human cohorts. Experimental Gerontology. PMID 26087330 DOI: 10.1016/j.exger.2015.05.012  1
2015 Jansen IE, Bras JM, Lesage S, Schulte C, Gibbs JR, Nalls MA, Brice A, Wood NW, Morris H, Hardy JA, Singleton AB, Gasser T, Heutink P, Sharma M. CHCHD2 and Parkinson's disease. The Lancet. Neurology. 14: 678-9. PMID 26067110 DOI: 10.1016/S1474-4422(15)00094-0  0.84
2015 Nichols N, Bras JM, Hernandez DG, Jansen IE, Lesage S, Lubbe S, Singleton AB. EIF4G1 mutations do not cause Parkinson's disease. Neurobiology of Aging. 36: 2444.e1-4. PMID 26022768 DOI: 10.1016/j.neurobiolaging.2015.04.017  1
2015 Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, ... ... Singleton AB, et al. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. Jama Neurology. 72: 781-8. PMID 25961151 DOI: 10.1001/jamaneurol.2015.0582  1
2015 Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, Li Y, Fu J, Karjalainen J, Platteel M, Visschedijk M, ... ... Singleton AB, et al. Cell Specific eQTL Analysis without Sorting Cells. Plos Genetics. 11: e1005223. PMID 25955312 DOI: 10.1371/journal.pgen.1005223  0.52
2015 Singleton AB, Traynor BJ. Genetics. For complex disease genetics, collaboration drives progress. Science (New York, N.Y.). 347: 1422-3. PMID 25814571 DOI: 10.1126/science.aaa9838  1
2015 Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, Yao C, Ying SX, Courchesne P, Milani L, Raghavachari N, ... ... Singleton A, et al. A meta-analysis of gene expression signatures of blood pressure and hypertension. Plos Genetics. 11: e1005035. PMID 25785607 DOI: 10.1371/journal.pgen.1005035  1
2015 Nalls MA, Escott-Price V, Williams NM, Lubbe S, Keller MF, Morris HR, Singleton AB. Genetic risk and age in Parkinson's disease: Continuum not stratum. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 850-4. PMID 25778492 DOI: 10.1002/mds.26192  1
2015 Escott-Price V, Nalls MA, Morris HR, Lubbe S, Brice A, Gasser T, Heutink P, Wood NW, Hardy J, Singleton AB, Williams NM. Polygenic risk of Parkinson disease is correlated with disease age at onset. Annals of Neurology. 77: 582-91. PMID 25773351 DOI: 10.1002/ana.24335  1
2015 Singleton A. A new gene for Parkinson's disease: should we care? The Lancet. Neurology. 14: 238-9. PMID 25728432 DOI: 10.1016/S1474-4422(14)70270-4  1
2015 Federoff M, Schottlaender LV, Houlden H, Singleton A. Multiple system atrophy: the application of genetics in understanding etiology. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society. 25: 19-36. PMID 25687905 DOI: 10.1007/s10286-014-0267-5  1
2015 Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, ... ... Singleton AB, et al. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry. PMID 25687773 DOI: 10.1038/mp.2015.6  1
2015 Gao J, Liu R, Zhao E, Huang X, Nalls MA, Singleton AB, Chen H. Head injury, potential interaction with genes, and risk for Parkinson's disease. Parkinsonism & Related Disorders. 21: 292-6. PMID 25603768 DOI: 10.1016/j.parkreldis.2014.12.033  0.68
2015 Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, Klopp N, Illig T, Hedman ÅK, Roden M, Hernandez DG, ... Singleton AB, et al. DNA methylation of lipid-related genes affects blood lipid levels. Circulation. Cardiovascular Genetics. 8: 334-42. PMID 25583993 DOI: 10.1161/CIRCGENETICS.114.000804  0.52
2015 Johnson JO, Stevanin G, van de Leemput J, Hernandez DG, Arepalli S, Forlani S, Zonozi R, Gibbs JR, Brice A, Durr A, Singleton AB. A 7.5-Mb duplication at chromosome 11q21-11q22.3 is associated with a novel spastic ataxia syndrome. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 262-6. PMID 25545641 DOI: 10.1002/mds.26059  1
2015 Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, Plagnol V, Gibbs JR, Schulte C, Pankratz N, Sutherland M, ... ... Singleton AB, et al. NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging. 36: 1605.e7-12. PMID 25444595 DOI: 10.1016/j.neurobiolaging.2014.07.028  1
2015 Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, Almeida M, Tanaka T, Perry JR, Gaulton K, Rivas M, ... ... Singleton A, et al. Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Human Molecular Genetics. 24: 1504-12. PMID 25378555 DOI: 10.1093/hmg/ddu560  0.48
2015 Schottlaender LV, Polke JM, Ling H, MacDoanld ND, Tucci A, Nanji T, Pittman A, de Silva R, Holton JL, Revesz T, Sweeney MG, Singleton AB, Lees AJ, Bhatia KP, Houlden H. The analysis of C9orf72 repeat expansions in a large series of clinically and pathologically diagnosed cases with atypical parkinsonism. Neurobiology of Aging. 36: 1221.e1-6. PMID 25308964 DOI: 10.1016/j.neurobiolaging.2014.08.024  1
2015 Scholz SW, Majounie E, Revesz T, Holton JL, Okun MS, Houlden H, Singleton AB. Multiple system atrophy is not caused by C9orf72 hexanucleotide repeat expansions. Neurobiology of Aging. 36: 1223.e1-2. PMID 25281017 DOI: 10.1016/j.neurobiolaging.2014.08.033  1
2015 Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, ... ... Singleton A, et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 110-8. PMID 25199915 DOI: 10.1093/gerona/glu166  1
2015 Ghani M, Lang AE, Zinman L, Nacmias B, Sorbi S, Bessi V, Tedde A, Tartaglia MC, Surace EI, Sato C, Moreno D, Xi Z, Hung R, Nalls MA, Singleton A, et al. Mutation analysis of patients with neurodegenerative disorders using NeuroX array. Neurobiology of Aging. 36: 545.e9-14. PMID 25174650 DOI: 10.1016/j.neurobiolaging.2014.07.038  0.68
2015 Barr TL, VanGilder R, Rellick S, Brooks SD, Doll DN, Lucke-Wold AN, Chen D, Denvir J, Warach S, Singleton A, Matarin M. A genomic profile of the immune response to stroke with implications for stroke recovery. Biological Research For Nursing. 17: 248-56. PMID 25124890 DOI: 10.1177/1099800414546492  0.6
2015 Chuang YF, Tanaka T, Beason-Held LL, An Y, Terracciano A, Sutin AR, Kraut M, Singleton AB, Resnick SM, Thambisetty M. FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet. Molecular Psychiatry. 20: 133-39. PMID 24863145 DOI: 10.1038/mp.2014.49  1
2015 Freitag D, Butterworth AS, Willeit P, Howson JMM, Burgess S, Kaptoge S, Young R, Ho WK, Wood AM, Sweeting M, Spackman S, Staley JR, Ramond A, Harshfield E, Nielsen SF, ... ... Singleton A, et al. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis The Lancet Diabetes and Endocrinology. 3: 243-253. DOI: 10.1016/S2213-8587(15)00034-0  0.68
2015 Ferrari R, Grassi M, Salvi E, Borroni B, Palluzzi F, Pepe D, D'Avila F, Padovani A, Archetti S, Rainero I, Rubino E, Pinessi L, Benussi L, Binetti G, Ghidoni R, ... ... Singleton A, et al. A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia Neurobiology of Aging. DOI: 10.1016/j.neurobiolaging.2015.06.005  1
2014 Bihlmeyer NA, Brody JA, Smith AV, Lunetta KL, Nalls M, Smith JA, Tanaka T, Davies G, Yu L, Mirza SS, Teumer A, Coresh J, Pankow JS, Franceschini N, Scaria A, ... ... Singleton AB, et al. Genetic diversity is a predictor of mortality in humans. Bmc Genetics. 15: 159. PMID 25543667 DOI: 10.1186/s12863-014-0159-7  1
2014 Heckman MG, Schottlaender L, Soto-Ortolaza AI, Diehl NN, Rayaprolu S, Ogaki K, Fujioka S, Murray ME, Cheshire WP, Uitti RJ, Wszolek ZK, Farrer MJ, Sailer A, Singleton AB, Chinnery PF, et al. LRRK2 exonic variants and risk of multiple system atrophy. Neurology. 83: 2256-61. PMID 25378673 DOI: 10.1212/WNL.0000000000001078  1
2014 Lin H, Joehanes R, Pilling LC, Dupuis J, Lunetta KL, Ying SX, Benjamin EJ, Hernandez D, Singleton A, Melzer D, Munson PJ, Levy D, Ferrucci L, Murabito JM. Whole blood gene expression and interleukin-6 levels. Genomics. 104: 490-5. PMID 25311648 DOI: 10.1016/j.ygeno.2014.10.003  1
2014 Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN. Another explanation for apparent epistasis. Nature. 514: E3-5. PMID 25279928 DOI: 10.1038/nature13691  1
2014 Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B, Williams J, et al. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis. Plos Medicine. 11: e1001713. PMID 25226301 DOI: 10.1371/journal.pmed.1001713  1
2014 Xi Z, Yunusova Y, van Blitterswijk M, Dib S, Ghani M, Moreno D, Sato C, Liang Y, Singleton A, Robertson J, Rademakers R, Zinman L, Rogaeva E. Identical twins with the C9orf72 repeat expansion are discordant for ALS. Neurology. 83: 1476-8. PMID 25209579 DOI: 10.1212/WNL.0000000000000886  1
2014 Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, De T, Coin L, de Silva R, Cookson MR, Singleton AB, Hardy J, Ryten M, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nature Neuroscience. 17: 1418-28. PMID 25174004 DOI: 10.1038/nn.3801  1
2014 Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Al-Sarraj S, Niblock M, Gallo JM, Adnan J, Killick R, Brown KS, Medway C, Lord J, Turton J, ... ... Singleton A, et al. Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease. Neurobiology of Aging. 35: 2881.e1-6. PMID 25104557 DOI: 10.1016/j.neurobiolaging.2014.06.002  1
2014 Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, ... ... Singleton AB, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. Plos Genetics. 10: e1004517. PMID 25102180 DOI: 10.1371/journal.pgen.1004517  1
2014 Keller MF, Reiner AP, Okada Y, van Rooij FJ, Johnson AD, Chen MH, Smith AV, Morris AP, Tanaka T, Ferrucci L, Zonderman AB, Lettre G, Harris T, Garcia M, Bandinelli S, ... ... Singleton AB, et al. Trans-ethnic meta-analysis of white blood cell phenotypes. Human Molecular Genetics. 23: 6944-60. PMID 25096241 DOI: 10.1093/hmg/ddu401  1
2014 Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, ... ... Singleton AB, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics. 46: 989-93. PMID 25064009 DOI: 10.1038/ng.3043  1
2014 Keller MF, Ferrucci L, Singleton AB, Tienari PJ, Laaksovirta H, Restagno G, Chiò A, Traynor BJ, Nalls MA. Genome-wide analysis of the heritability of amyotrophic lateral sclerosis. Jama Neurology. 71: 1123-34. PMID 25023141 DOI: 10.1001/jamaneurol.2014.1184  1
2014 Kara E, Kiely AP, Proukakis C, Giffin N, Love S, Hehir J, Rantell K, Pandraud A, Hernandez DG, Nacheva E, Pittman AM, Nalls MA, Singleton AB, Revesz T, Bhatia KP, et al. A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations. Jama Neurology. 71: 1162-71. PMID 25003242 DOI: 10.1001/jamaneurol.2014.994  1
2014 Mencacci NE, Isaias IU, Reich MM, Ganos C, Plagnol V, Polke JM, Bras J, Hersheson J, Stamelou M, Pittman AM, Noyce AJ, Mok KY, Opladen T, Kunstmann E, Hodecker S, ... ... Singleton A, et al. Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain : a Journal of Neurology. 137: 2480-92. PMID 24993959 DOI: 10.1093/brain/awu179  1
2014 Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, Marder K, Van Der Flier WM, Lemstra A, Scheltens P, Rogaeva E, ... ... Singleton A, et al. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human Molecular Genetics. 23: 6139-46. PMID 24973356 DOI: 10.1093/hmg/ddu334  1
2014 Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, ... ... Singleton AB, et al. Frontotemporal dementia and its subtypes: a genome-wide association study. The Lancet. Neurology. 13: 686-99. PMID 24943344 DOI: 10.1016/S1474-4422(14)70065-1  0.68
2014 Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Mann D, Snowden J, Neary D, ... ... Singleton A, et al. Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiology of Aging. 35: 2422.e13-6. PMID 24880964 DOI: 10.1016/j.neurobiolaging.2014.04.026  1
2014 Guerreiro R, Brás J, Hardy J, Singleton A. Next generation sequencing techniques in neurological diseases: redefining clinical and molecular associations. Human Molecular Genetics. 23: R47-53. PMID 24794858 DOI: 10.1093/hmg/ddu203  1
2014 Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, ... ... Singleton AB, et al. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience. 17: 664-6. PMID 24686783 DOI: 10.1038/nn.3688  1
2014 Agler C, Nielsen DM, Urkasemsin G, Singleton A, Tonomura N, Sigurdsson S, Tang R, Linder K, Arepalli S, Hernandez D, Lindblad-Toh K, van de Leemput J, Motsinger-Reif A, O'Brien DP, Bell J, et al. Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24. Plos Genetics. 10: e1003991. PMID 24516392 DOI: 10.1371/journal.pgen.1003991  1
2014 Sangaré M, Hendrickson B, Sango HA, Chen K, Nofziger J, Amara A, Dutra A, Schindler AB, Guindo A, Traoré M, Harmison G, Pak E, Yaro FN, Bricceno K, Grunseich C, ... ... Singleton AB, et al. Genetics of low spinal muscular atrophy carrier frequency in sub-Saharan Africa. Annals of Neurology. 75: 525-32. PMID 24515897 DOI: 10.1002/ana.24114  1
2014 Singleton AB. Genetics. A unified process for neurological disease. Science (New York, N.Y.). 343: 497-8. PMID 24482474 DOI: 10.1126/science.1250172  1
2014 Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW. Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mechanisms of Ageing and Development. 135: 50-6. PMID 24463145 DOI: 10.1016/j.mad.2014.01.005  1
2014 Dong J, Gao J, Nalls M, Gao X, Huang X, Han J, Singleton AB, Chen H. Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease. Neurobiology of Aging. 35: 1512.e5-10. PMID 24439955 DOI: 10.1016/j.neurobiolaging.2013.12.020  1
2014 Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Singleton A, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/j.neurobiolaging.2013.12.010  1
2014 Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, ... ... Singleton AB, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/nature12825  1
2014 Tucci A, Liu YT, Preza E, Pitceathly RD, Chalasani A, Plagnol V, Land JM, Trabzuni D, Ryten M, Jaunmuktane Z, Reilly MM, Brandner S, Hargreaves I, Hardy J, ... Singleton AB, et al. Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy. Journal of Neurology, Neurosurgery, and Psychiatry. 85: 486-92. PMID 24198383 DOI: 10.1136/jnnp-2013-306387  1
2014 Kara E, Xiromerisiou G, Spanaki C, Bozi M, Koutsis G, Panas M, Dardiotis E, Ralli S, Bras J, Letson C, Edsall C, Pliner H, Arepalli S, Kalinderi K, Fidani L, ... ... Singleton AB, et al. Assessment of Parkinson's disease risk loci in Greece. Neurobiology of Aging. 35: 442.e9-442.e16. PMID 24080174 DOI: 10.1016/j.neurobiolaging.2013.07.011  1
2014 Nalls MA, Saad M, Noyce AJ, Keller MF, Schrag A, Bestwick JP, Traynor BJ, Gibbs JR, Hernandez DG, Cookson MR, Morris HR, Williams N, Gasser T, Heutink P, Wood N, ... ... Singleton AB, et al. Genetic comorbidities in Parkinson's disease. Human Molecular Genetics. 23: 831-41. PMID 24057672 DOI: 10.1093/hmg/ddt465  1
2014 Schulze TG, Akula N, Breuer R, Steele J, Nalls MA, Singleton AB, Degenhardt FA, Nöthen MM, Cichon S, Rietschel M, McMahon FJ. Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 15: 200-8. PMID 22404658 DOI: 10.3109/15622975.2012.662282  1
2014 Holmans P, Moskvina V, Jones L, Sharma M, Vedernikov A, Buchel F, Saad M, Bras JM, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Gibbs JR, Schulte C, Durr A, ... ... Singleton AB, et al. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease [Human Molecular Genetics 22, 5, 2013, 1039-1049] doi:10.1093/hmg/dds492 Human Molecular Genetics. 23: 562. DOI: 10.1093/hmg/ddt554  1
2014 Heckman MG, Schottlaender L, Soto-Ortolaza AI, Diehl NN, Rayaprolu S, Ogaki K, Fujioka S, Murray ME, Cheshire WP, Uitti RJ, Wszolek ZK, Farrer MJ, Sailer A, Singleton AB, Chinnery PF, et al. LRRK2 exonic variants and risk of multiple system atrophy Neurology. 83: 2256-2261.  1
2013 Sumner CJ, d'Ydewalle C, Wooley J, Fawcett KA, Hernandez D, Gardiner AR, Kalmar B, Baloh RH, Gonzalez M, Züchner S, Stanescu HC, Kleta R, Mankodi A, Cornblath DR, Boylan KB, ... ... Singleton AB, et al. A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance. American Journal of Human Genetics. 93: 976-83. PMID 24207122 DOI: 10.1016/j.ajhg.2013.10.006  1
2013 Ross OA, Soto-Ortolaza AI, Heckman MG, Verbeeck C, Serie DJ, Rayaprolu S, Rich SS, Nalls MA, Singleton A, Guerreiro R, Kinsella E, Wszolek ZK, Brott TG, Brown RD, Worrall BB, et al. NOTCH3 variants and risk of ischemic stroke. Plos One. 8: e75035. PMID 24086431 DOI: 10.1371/journal.pone.0075035  1
2013 O'Seaghdha CM, Wu H, Yang Q, Kapur K, Guessous I, Zuber AM, Köttgen A, Stoudmann C, Teumer A, Kutalik Z, Mangino M, Dehghan A, Zhang W, Eiriksdottir G, Li G, ... ... Singleton AB, et al. Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. Plos Genetics. 9: e1003796. PMID 24068962 DOI: 10.1371/journal.pgen.1003796  1
2013 Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, Zhernakova A, Zhernakova DV, Veldink JH, Van den Berg LH, Karjalainen J, ... ... Singleton AB, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics. 45: 1238-43. PMID 24013639 DOI: 10.1038/ng.2756  1
2013 Kang JH, Irwin DJ, Chen-Plotkin AS, Siderowf A, Caspell C, Coffey CS, Waligórska T, Taylor P, Pan S, Frasier M, Marek K, Kieburtz K, Jennings D, Simuni T, Tanner CM, ... Singleton A, et al. Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. Jama Neurology. 70: 1277-87. PMID 23979011 DOI: 10.1001/jamaneurol.2013.3861  1
2013 Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, ... ... Singleton AB, et al. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. American Journal of Human Genetics. 93: 545-54. PMID 23972371 DOI: 10.1016/j.ajhg.2013.07.010  1
2013 Trabzuni D, Ryten M, Emmett W, Ramasamy A, Lackner KJ, Zeller T, Walker R, Smith C, Lewis PA, Mamais A, de Silva R, Vandrovcova J, Hernandez D, Nalls MA, ... ... Singleton A, et al. Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. Plos One. 8: e70724. PMID 23967090 DOI: 10.1371/journal.pone.0070724  1
2013 Paisán-Ruiz C, Lewis PA, Singleton AB. LRRK2: cause, risk, and mechanism. Journal of Parkinson's Disease. 3: 85-103. PMID 23938341 DOI: 10.3233/JPD-130192  1
2013 Moskvina V, Harold D, Russo G, Vedernikov A, Sharma M, Saad M, Holmans P, Bras JM, Bettella F, Keller MF, Nicolaou N, Simón-Sánchez J, Gibbs JR, Schulte C, Durr A, ... ... Singleton AB, et al. Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. Jama Neurology. 70: 1268-76. PMID 23921447 DOI: 10.1001/jamaneurol.2013.448  1
2013 Bettencourt C, Morris HR, Singleton AB, Hardy J, Houlden H. Exome sequencing expands the mutational spectrum of SPG8 in a family with spasticity responsive to L-DOPA treatment. Journal of Neurology. 260: 2414-6. PMID 23881105 DOI: 10.1007/s00415-013-7044-6  1
2013 Thompson AJ, Scholz SW, Singleton AB, Hardwick A, McFarland NR, Okun MS. Variability in clinical phenotypes of heterozygous and homozygous cases of Parkin-related Parkinson's disease. The International Journal of Neuroscience. 123: 847-9. PMID 23767969 DOI: 10.3109/00207454.2013.810626  1
2013 Wood AR, Perry JR, Tanaka T, Hernandez DG, Zheng HF, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, Richards JB, Bandinelli S, Ferrucci L, Singleton AB, Frayling TM. Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. Plos One. 8: e64343. PMID 23696881 DOI: 10.1371/journal.pone.0064343  1
2013 Hudson G, Nalls M, Evans JR, Breen DP, Winder-Rhodes S, Morrison KE, Morris HR, Williams-Gray CH, Barker RA, Singleton AB, Hardy J, Wood NE, Burn DJ, Chinnery PF. Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease. Neurology. 80: 2042-8. PMID 23645593 DOI: 10.1212/WNL.0b013e318294b434  1
2013 Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkilä V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, ... ... Singleton A, et al. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. The American Journal of Clinical Nutrition. 97: 1395-402. PMID 23636237 DOI: 10.3945/ajcn.112.052183  1
2013 Singleton AB. Finding risk in all the right places. Neuron. 78: 207-8. PMID 23622057 DOI: 10.1016/j.neuron.2013.04.011  1
2013 Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DM, Snowden J, ... ... Singleton AB, et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. Jama Neurology. 70: 727-35. PMID 23588557 DOI: 10.1001/jamaneurol.2013.1925  1
2013 den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, ... ... Singleton AB, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45: 621-31. PMID 23583979 DOI: 10.1038/ng.2610  0.36
2013 Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, ... ... Singleton AB, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nature Genetics. 45: 690-6. PMID 23583978 DOI: 10.1038/ng.2608  0.68
2013 Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, Hubacek JA, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Abdollahi MR, ... ... Singleton A, et al. Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. International Journal of Epidemiology. 42: 475-92. PMID 23569189 DOI: 10.1093/ije/dyt034  1
2013 Siitonen A, Majounie E, Federoff M, Ding J, Majamaa K, Singleton AB. Mutations in EIF4G1 are not a common cause of Parkinson's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 20: e59. PMID 23490116 DOI: 10.1111/ene.12051  1
2013 Chen Z, Tang H, Qayyum R, Schick UM, Nalls MA, Handsaker R, Li J, Lu Y, Yanek LR, Keating B, Meng Y, van Rooij FJ, Okada Y, Kubo M, Rasmussen-Torvik L, ... ... Singleton AB, et al. Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. Human Molecular Genetics. 22: 2529-38. PMID 23446634 DOI: 10.1093/hmg/ddt087  1
2013 Ramasamy A, Trabzuni D, Gibbs JR, Dillman A, Hernandez DG, Arepalli S, Walker R, Smith C, Ilori GP, Shabalin AA, Li Y, Singleton AB, Cookson MR, Hardy J, et al. Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies. Nucleic Acids Research. 41: e88. PMID 23435227 DOI: 10.1093/nar/gkt069  1
2013 Majounie E, Cross W, Newsway V, Dillman A, Vandrovcova J, Morris CM, Nalls MA, Ferrucci L, Owen MJ, O'Donovan MC, Cookson MR, Singleton AB, de Silva R, Morris HR. Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging. 34: 1922.e7-1922.e12. PMID 23428180 DOI: 10.1016/j.neurobiolaging.2013.01.017  1
2013 Klebe S, Golmard JL, Nalls MA, Saad M, Singleton AB, Bras JM, Hardy J, Simon-Sanchez J, Heutink P, Kuhlenbäumer G, Charfi R, Klein C, Hagenah J, Gasser T, Wurster I, et al. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 666-73. PMID 23408064 DOI: 10.1136/jnnp-2012-304475  1
2013 Appenzeller S, Schulte C, Thier S, Hopfner F, Pendziwiat M, Papengut F, Klein C, Hagenah J, Kasten M, Srulijes K, Berg D, Gasser T, Singleton A, Deuschl G, Kuhlenbäumer G. No association between polymorphisms in the glutamate transporter SLC1A2 and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1305-6. PMID 23390085 DOI: 10.1002/mds.25330  1
2013 Singleton AB, Farrer MJ, Bonifati V. The genetics of Parkinson's disease: progress and therapeutic implications. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 14-23. PMID 23389780 DOI: 10.1002/mds.25249  1
2013 Anderson CD, Biffi A, Nalls MA, Devan WJ, Schwab K, Ayres AM, Valant V, Ross OA, Rost NS, Saxena R, Viswanathan A, Worrall BB, Brott TG, Goldstein JN, Brown D, ... ... Singleton AB, et al. Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage. Stroke; a Journal of Cerebral Circulation. 44: 612-9. PMID 23362085 DOI: 10.1161/STROKEAHA.112.672089  1
2013 Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Ramirez-Restrepo M, ... ... Singleton A, et al. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Annals of Human Genetics. 77: 85-105. PMID 23360175 DOI: 10.1111/ahg.12000  1
2013 Hammer MB, Eleuch-Fayache G, Schottlaender LV, Nehdi H, Gibbs JR, Arepalli SK, Chong SB, Hernandez DG, Sailer A, Liu G, Mistry PK, Cai H, Shrader G, Sassi C, Bouhlal Y, ... ... Singleton AB, et al. Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity. American Journal of Human Genetics. 92: 245-51. PMID 23332917 DOI: 10.1016/j.ajhg.2012.12.012  1
2013 Guerreiro RJ, Lohmann E, Brás JM, Gibbs JR, Rohrer JD, Gurunlian N, Dursun B, Bilgic B, Hanagasi H, Gurvit H, Emre M, Singleton A, Hardy J. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. Jama Neurology. 70: 78-84. PMID 23318515 DOI: 10.1001/jamaneurol.2013.579  1
2013 Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, ... ... Singleton AB, et al. Genetic variation associated with circulating monocyte count in the eMERGE Network. Human Molecular Genetics. 22: 2119-27. PMID 23314186 DOI: 10.1093/hmg/ddt010  1
2013 Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW. Towards a gene expression biomarker set for human biological age. Aging Cell. 12: 324-6. PMID 23311345 DOI: 10.1111/acel.12044  1
2013 Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, Liu Y, Marciante K, Meirelles O, Nalls MA, Sun YV, ... ... Singleton AB, et al. A genome-wide association study of depressive symptoms. Biological Psychiatry. 73: 667-78. PMID 23290196 DOI: 10.1016/j.biopsych.2012.09.033  1
2013 Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, ... ... Singleton AB, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics. 45: 145-54. PMID 23263486 DOI: 10.1038/ng.2500  0.36
2013 Salehi B, Preuss N, van der Veen JW, Shen J, Neumeister A, Drevets WC, Hodgkinson C, Goldman D, Wendland JR, Singleton A, Gibbs JR, Cookson MR, Hasler G. Age-modulated association between prefrontal NAA and the BDNF gene. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1185-93. PMID 23253771 DOI: 10.1017/S1461145712001204  1
2013 Holmans P, Moskvina V, Jones L, Sharma M, Vedernikov A, Buchel F, Saad M, Sadd M, Bras JM, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Gibbs JR, ... ... Singleton AB, et al. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Human Molecular Genetics. 22: 1039-49. PMID 23223016 DOI: 10.1093/hmg/dds492  1
2013 Deo R, Nalls MA, Avery CL, Smith JG, Evans DS, Keller MF, Butler AM, Buxbaum SG, Li G, Miguel Quibrera P, Smith EN, Tanaka T, Akylbekova EL, Alonso A, Arking DE, ... ... Singleton AB, et al. Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 401-8. PMID 23183192 DOI: 10.1016/j.hrthm.2012.11.014  1
2013 Kumar A, Gibbs JR, Beilina A, Dillman A, Kumaran R, Trabzuni D, Ryten M, Walker R, Smith C, Traynor BJ, Hardy J, Singleton AB, Cookson MR. Age-associated changes in gene expression in human brain and isolated neurons. Neurobiology of Aging. 34: 1199-209. PMID 23177596 DOI: 10.1016/j.neurobiolaging.2012.10.021  1
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, ... ... Singleton A, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/NEJMoa1211851  1
2013 Tucci A, Kara E, Schossig A, Wolf NI, Plagnol V, Fawcett K, Paisán-Ruiz C, Moore M, Hernandez D, Musumeci S, Tennison M, Hennekam R, Palmeri S, Malandrini A, Raskin S, ... ... Singleton A, et al. Kohlschütter-Tönz syndrome: mutations in ROGDI and evidence of genetic heterogeneity. Human Mutation. 34: 296-300. PMID 23086778 DOI: 10.1002/humu.22241  1
2013 Hammer MB, Eleuch-Fayache G, Gibbs JR, Arepalli SK, Chong SB, Sassi C, Bouhlal Y, Hentati F, Amouri R, Singleton AB. Exome sequencing: an efficient diagnostic tool for complex neurodegenerative disorders. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 20: 486-92. PMID 23043354 DOI: 10.1111/j.1468-1331.2012.03883.x  1
2013 Thambisetty M, An Y, Nalls M, Sojkova J, Swaminathan S, Zhou Y, Singleton AB, Wong DF, Ferrucci L, Saykin AJ, Resnick SM. Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype. Biological Psychiatry. 73: 422-8. PMID 23022416 DOI: 10.1016/j.biopsych.2012.08.015  1
2013 Thambisetty M, Beason-Held LL, An Y, Kraut M, Nalls M, Hernandez DG, Singleton AB, Zonderman AB, Ferrucci L, Lovestone S, Resnick SM. Alzheimer risk variant CLU and brain function during aging. Biological Psychiatry. 73: 399-405. PMID 22795969 DOI: 10.1016/j.biopsych.2012.05.026  1
2013 Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Siḿn-śnchez J, Mittag F, B̈chel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, ... ... Singleton AB, et al. Corrigendum to Using genome-wide complex trait analysis to quantify 'missing heritability' in parkinson's disease [Human Molecular Genetics, 21:22 (2012) 4996-5009] doi: 10.1093/hmg/dds335] Human Molecular Genetics. 22: 1696. DOI: 10.1093/hmg/ddt030  1
2012 Smith JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C, Tanaka T, Mehra R, Butler AM, Young T, Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, ... ... Singleton AB, et al. Impact of ancestry and common genetic variants on QT interval in African Americans. Circulation. Cardiovascular Genetics. 5: 647-55. PMID 23166209 DOI: 10.1161/CIRCGENETICS.112.962787  1
2012 Kuhn A, Kumar A, Beilina A, Dillman A, Cookson MR, Singleton AB. Cell population-specific expression analysis of human cerebellum. Bmc Genomics. 13: 610. PMID 23145530 DOI: 10.1186/1471-2164-13-610  1
2012 Butler AM, Yin X, Evans DS, Nalls MA, Smith EN, Tanaka T, Li G, Buxbaum SG, Whitsel EA, Alonso A, Arking DE, Benjamin EJ, Berenson GS, Bis JC, Chen W, ... ... Singleton AB, et al. Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. Circulation. Cardiovascular Genetics. 5: 639-46. PMID 23139255 DOI: 10.1161/CIRCGENETICS.112.963991  1
2012 Schlebusch CM, Skoglund P, Sjödin P, Gattepaille LM, Hernandez D, Jay F, Li S, De Jongh M, Singleton A, Blum MG, Soodyall H, Jakobsson M. Genomic variation in seven Khoe-San groups reveals adaptation and complex African history. Science (New York, N.Y.). 338: 374-9. PMID 22997136 DOI: 10.1126/science.1227721  1
2012 Hernandez DG, Nalls MA, Ylikotila P, Keller M, Hardy JA, Majamaa K, Singleton AB. Genome wide assessment of young onset Parkinson's disease from Finland. Plos One. 7: e41859. PMID 22911860 DOI: 10.1371/journal.pone.0041859  1
2012 Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, ... ... Singleton AB, et al. Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Human Molecular Genetics. 21: 4996-5009. PMID 22892372 DOI: 10.1093/hmg/dds335  1
2012 Camargos S, Lees AJ, Singleton A, Cardoso F. DYT16: the original cases. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 1012-4. PMID 22842711 DOI: 10.1136/jnnp-2012-302841  0.48
2012 David SP, Hamidovic A, Chen GK, Bergen AW, Wessel J, Kasberger JL, Brown WM, Petruzella S, Thacker EL, Kim Y, Nalls MA, Tranah GJ, Sung YJ, Ambrosone CB, Arnett D, ... ... Singleton AB, et al. Genome-wide meta-analyses of smoking behaviors in African Americans. Translational Psychiatry. 2: e119. PMID 22832964 DOI: 10.1038/tp.2012.41  1
2012 Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of Ageing and Development. 133: 556-62. PMID 22813852 DOI: 10.1016/j.mad.2012.07.003  0.48
2012 Houlden H, Singleton AB. The genetics and neuropathology of Parkinson's disease. Acta Neuropathologica. 124: 325-38. PMID 22806825 DOI: 10.1007/s00401-012-1013-5  1
2012 Mittag F, Büchel F, Saad M, Jahn A, Schulte C, Bochdanovits Z, Simón-Sánchez J, Nalls MA, Keller M, Hernandez DG, Gibbs JR, Lesage S, Brice A, Heutink P, Martinez M, ... ... Singleton AB, et al. Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities. Human Mutation. 33: 1708-18. PMID 22777693 DOI: 10.1002/humu.22161  1
2012 Gao J, Nalls MA, Shi M, Joubert BR, Hernandez DG, Huang X, Hollenbeck A, Singleton AB, Chen H. An exploratory analysis on gene-environment interactions for Parkinson disease. Neurobiology of Aging. 33: 2528.e1-6. PMID 22763023 DOI: 10.1016/j.neurobiolaging.2012.06.007  1
2012 Johnson JO, Gibbs JR, Megarbane A, Urtizberea JA, Hernandez DG, Foley AR, Arepalli S, Pandraud A, Simón-Sánchez J, Clayton P, Reilly MM, Muntoni F, Abramzon Y, Houlden H, Singleton AB. Exome sequencing reveals riboflavin transporter mutations as a cause of motor neuron disease. Brain : a Journal of Neurology. 135: 2875-82. PMID 22740598 DOI: 10.1093/brain/aws161  1
2012 Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, Smith C, Luk C, Gibbs JR, Dillman A, Hernandez DG, Arepalli S, Singleton AB, Cookson MR, Pittman AM, de Silva R, et al. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Human Molecular Genetics. 21: 4094-103. PMID 22723018 DOI: 10.1093/hmg/dds238  1
2012 Majounie E, Abramzon Y, Renton AE, Keller MF, Traynor BJ, Singleton AB. Large C9orf72 repeat expansions are not a common cause of Parkinson's disease. Neurobiology of Aging. 33: 2527.e1-2. PMID 22721568 DOI: 10.1016/j.neurobiolaging.2012.05.007  1
2012 Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff HJ, Traynor BJ, Singleton AB, Houlden H. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 79: 127-31. PMID 22675081 DOI: 10.1212/WNL.0b013e31825f048e  1
2012 Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Research. 15: 395-404. PMID 22607625 DOI: 10.1089/rej.2011.1302  0.48
2012 Lohmann E, Guerreiro RJ, Erginel-Unaltuna N, Gurunlian N, Bilgic B, Gurvit H, Hanagasi HA, Luu N, Emre M, Singleton A. Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients. Neurobiology of Aging. 33: 1850.e17-27. PMID 22503161 DOI: 10.1016/j.neurobiolaging.2012.02.020  1
2012 Singleton AB. Rapid genetic diagnosis in single-gene movement disorders. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 467-9. PMID 22488858 DOI: 10.1002/mds.24896  1
2012 Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, ... ... Singleton AB, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. Plos Genetics. 8: e1002548. PMID 22438815 DOI: 10.1371/journal.pgen.1002548  1
2012 Hernandez DG, Nalls MA, Moore M, Chong S, Dillman A, Trabzuni D, Gibbs JR, Ryten M, Arepalli S, Weale ME, Zonderman AB, Troncoso J, O'Brien R, Walker R, Smith C, ... ... Singleton AB, et al. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiology of Disease. 47: 20-8. PMID 22433082 DOI: 10.1016/j.nbd.2012.03.020  1
2012 Simón-Sánchez J, Kilarski LL, Nalls MA, Martinez M, Schulte C, Holmans P, Gasser T, Hardy J, Singleton AB, Wood NW, Brice A, Heutink P, Williams N, et al. Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease. Plos One. 7: e28787. PMID 22427796 DOI: 10.1371/journal.pone.0028787  1
2012 Qayyum R, Snively BM, Ziv E, Nalls MA, Liu Y, Tang W, Yanek LR, Lange L, Evans MK, Ganesh S, Austin MA, Lettre G, Becker DM, Zonderman AB, Singleton AB, et al. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. Plos Genetics. 8: e1002491. PMID 22423221 DOI: 10.1371/journal.pgen.1002491  1
2012 Federoff M, Jimenez-Rolando B, Nalls MA, Singleton AB. A large study reveals no association between APOE and Parkinson's disease. Neurobiology of Disease. 46: 389-92. PMID 22349451 DOI: 10.1016/j.nbd.2012.02.002  1
2012 Wu J, Lou H, Alerte TN, Stachowski EK, Chen J, Singleton AB, Hamilton RL, Perez RG. Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo. Neuroscience. 207: 288-97. PMID 22326202 DOI: 10.1016/j.neuroscience.2012.01.028  1
2012 Ross OA, Singleton AB. Does trans size matter in Huntington disease? Neurology. 78: 686-7. PMID 22323751 DOI: 10.1212/WNL.0b013e3182494d77  1
2012 Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N, Gudbjartsson DF, Hottenga JJ, Kraft P, ... ... Singleton A, et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics. 44: 260-8. PMID 22267201 DOI: 10.1038/ng.1051  0.36
2012 Majounie E, Abramzon Y, Renton AE, Perry R, Bassett SS, Pletnikova O, Troncoso JC, Hardy J, Singleton AB, Traynor BJ. Repeat expansion in C9ORF72 in Alzheimer's disease. The New England Journal of Medicine. 366: 283-4. PMID 22216764 DOI: 10.1056/NEJMc1113592  1
2012 Guerreiro RJ, Lohmann E, Kinsella E, Brás JM, Luu N, Gurunlian N, Dursun B, Bilgic B, Santana I, Hanagasi H, Gurvit H, Gibbs JR, Oliveira C, Emre M, Singleton A. Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease. Neurobiology of Aging. 33: 1008.e17-23. PMID 22153900 DOI: 10.1016/j.neurobiolaging.2011.10.009  1
2012 Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D. CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell. 11: 262-8. PMID 22152057 DOI: 10.1111/j.1474-9726.2011.00782.x  1
2012 Hernandez DG, Singleton AB. Using DNA methylation to understand biological consequences of genetic variability. Neuro-Degenerative Diseases. 9: 53-9. PMID 22123027 DOI: 10.1159/000333097  1
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Singleton AB, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/JAD-2011-110824  1
2012 Majounie E, Traynor BJ, Chiò A, Restagno G, Mandrioli J, Benatar M, Taylor JP, Singleton AB. Mutational analysis of the VCP gene in Parkinson's disease. Neurobiology of Aging. 33: 209.e1-2. PMID 21920633 DOI: 10.1016/j.neurobiolaging.2011.07.011  1
2011 N'Diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, Ding J, Nalls MA, Adeyemo A, Adoue V, Ambrosone CB, Atwood L, Bandera EV, Becker LC, Berndt SI, ... ... Singleton AB, et al. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. Plos Genetics. 7: e1002298. PMID 21998595 DOI: 10.1371/journal.pgen.1002298  1
2011 Meschia JF, Singleton A, Nalls MA, Rich SS, Sharma P, Ferrucci L, Matarin M, Hernandez DG, Pearce K, Brott TG, Brown RD, Hardy J, Worrall BB. Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis. Plos One. 6: e23161. PMID 21957438 DOI: 10.1371/journal.pone.0023161  1
2011 Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, ... ... Singleton A, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 72: 257-68. PMID 21944779 DOI: 10.1016/j.neuron.2011.09.010  1
2011 Meschia JF, Nalls M, Matarin M, Brott TG, Brown RD, Hardy J, Kissela B, Rich SS, Singleton A, Hernandez D, Ferrucci L, Pearce K, Keller M, Worrall BB. Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci. Stroke; a Journal of Cerebral Circulation. 42: 2726-32. PMID 21940970 DOI: 10.1161/STROKEAHA.111.620484  1
2011 Singleton AB. Exome sequencing: a transformative technology. The Lancet. Neurology. 10: 942-6. PMID 21939903 DOI: 10.1016/S1474-4422(11)70196-X  1
2011 Akula N, Baranova A, Seto D, Solka J, Nalls MA, Singleton A, Ferrucci L, Tanaka T, Bandinelli S, Cho YS, Kim YJ, Lee JY, Han BG, et al. A network-based approach to prioritize results from genome-wide association studies. Plos One. 6: e24220. PMID 21915301 DOI: 10.1371/journal.pone.0024220  1
2011 Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, ... ... Singleton A, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 478: 103-9. PMID 21909115 DOI: 10.1038/nature10405  0.68
2011 Devine MJ, Gwinn K, Singleton A, Hardy J. Parkinson's disease and α-synuclein expression. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2160-8. PMID 21887711 DOI: 10.1002/mds.23948  1
2011 Singleton A, Hardy J. A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci. Human Molecular Genetics. 20: R158-62. PMID 21875901 DOI: 10.1093/hmg/ddr358  1
2011 Holmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J, Breteler MM, Bautista LE, Sharma P, Whittaker JC, Smeeth L, Fowkes FG, Algra A, Shmeleva V, Szolnoki Z, ... ... Singleton AB, et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet. 378: 584-94. PMID 21803414 DOI: 10.1016/S0140-6736(11)60872-6  1
2011 Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, Bandinelli S, Murray A, Ferrucci L, Singleton AB, Melzer D, et al. Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Human Molecular Genetics. 20: 4082-92. PMID 21798870 DOI: 10.1093/hmg/ddr328  1
2011 Nalls MA, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, Wood AR, Garcia M, Gasparini P, Liu Y, Lumley T, ... ... Singleton AB, et al. Multiple loci are associated with white blood cell phenotypes. Plos Genetics. 7: e1002113. PMID 21738480 DOI: 10.1371/journal.pgen.1002113  0.68
2011 Reiner AP, Lettre G, Nalls MA, Ganesh SK, Mathias R, Austin MA, Dean E, Arepalli S, Britton A, Chen Z, Couper D, Curb JD, Eaton CB, Fornage M, Grant SF, ... ... Singleton AB, et al. Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). Plos Genetics. 7: e1002108. PMID 21738479 DOI: 10.1371/journal.pgen.1002108  1
2011 Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, ... ... Singleton AB, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 43: 699-705. PMID 21685912 DOI: 10.1038/ng.859  1
2011 Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell. 10: 868-78. PMID 21668623 DOI: 10.1111/j.1474-9726.2011.00726.x  1
2011 Gwinn K, Devine MJ, Jin LW, Johnson J, Bird T, Muenter M, Waters C, Adler CH, Caselli R, Houlden H, Lopez G, Singleton A, Hardy J, Singleton A. Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred). Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2134-6. PMID 21656851 DOI: 10.1002/mds.23776  1
2011 Peuralinna T, Tanskanen M, Mäkelä M, Polvikoski T, Paetau A, Kalimo H, Sulkava R, Hardy J, Lai SL, Arepalli S, Hernandez D, Traynor BJ, Singleton A, Tienari PJ, Myllykangas L. APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis. Journal of Alzheimer's Disease : Jad. 26: 377-85. PMID 21654062 DOI: 10.3233/JAD-2011-102049  1
2011 Bras JM, Singleton AB. Exome sequencing in Parkinson's disease. Clinical Genetics. 80: 104-9. PMID 21651510 DOI: 10.1111/j.1399-0004.2011.01722.x  0.56
2011 Stemberger S, Scholz SW, Singleton AB, Wenning GK. Genetic players in multiple system atrophy: unfolding the nature of the beast. Neurobiology of Aging. 32: 1924.e5-14. PMID 21601954 DOI: 10.1016/j.neurobiolaging.2011.04.001  1
2011 Marelli C, van de Leemput J, Johnson JO, Tison F, Thauvin-Robinet C, Picard F, Tranchant C, Hernandez DG, Huttin B, Boulliat J, Sangla I, Marescaux C, Brique S, Dollfus H, Arepalli S, ... ... Singleton A, et al. SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia. Archives of Neurology. 68: 637-43. PMID 21555639 DOI: 10.1001/archneurol.2011.81  1
2011 Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Singleton AB, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/ng.803  1
2011 Anderson CD, Nalls MA, Biffi A, Rost NS, Greenberg SM, Singleton AB, Meschia JF, Rosand J. The effect of survival bias on case-control genetic association studies of highly lethal diseases. Circulation. Cardiovascular Genetics. 4: 188-96. PMID 21292865 DOI: 10.1161/CIRCGENETICS.110.957928  1
2011 Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, ... ... Singleton AB, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 377: 641-9. PMID 21292315 DOI: 10.1016/S0140-6736(10)62345-8  1
2011 Simón-Sánchez J, van Hilten JJ, van de Warrenburg B, Post B, Berendse HW, Arepalli S, Hernandez DG, de Bie RM, Velseboer D, Scheffer H, Bloem B, van Dijk KD, Rivadeneira F, Hofman A, Uitterlinden AG, ... ... Singleton AB, et al. Genome-wide association study confirms extant PD risk loci among the Dutch. European Journal of Human Genetics : Ejhg. 19: 655-61. PMID 21248740 DOI: 10.1038/ejhg.2010.254  1
2011 Hernandez DG, Nalls MA, Gibbs JR, Arepalli S, van der Brug M, Chong S, Moore M, Longo DL, Cookson MR, Traynor BJ, Singleton AB. Distinct DNA methylation changes highly correlated with chronological age in the human brain. Human Molecular Genetics. 20: 1164-72. PMID 21216877 DOI: 10.1093/hmg/ddq561  1
2011 Pearson JP, Williams NM, Majounie E, Waite A, Stott J, Newsway V, Murray A, Hernandez D, Guerreiro R, Singleton AB, Neal J, Morris HR. Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p. Journal of Neurology. 258: 647-55. PMID 21072532 DOI: 10.1007/s00415-010-5815-x  1
2011 Peckham EL, Lopez G, Shamim EA, Richardson SP, Sanku S, Malkani R, Stacy M, Mahant P, Crawley A, Singleton A, Hallett M. Clinical features of patients with blepharospasm: a report of 240 patients. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 18: 382-6. PMID 20649903 DOI: 10.1111/j.1468-1331.2010.03161.x  1
2011 Camargos ST, Gurgel-Giannetti J, Lees A, Hardy J, Singleton A, Cardoso F. Low prevalence of PANK2 mutations in Brazilian patients with early onset generalised dystonia and basal ganglia abnormalities on MRI. Journal of Neurology, Neurosurgery, and Psychiatry. 82: 1059-60. PMID 20551478 DOI: 10.1136/jnnp.2009.200808  1
2011 Brooks JA, Houlden H, Melchers A, Islam AJ, Ding J, Li A, Paudel R, Revesz T, Holton JL, Wood N, Lees A, Singleton AB, Scholz SW. Mutational analysis of parkin and PINK1 in multiple system atrophy. Neurobiology of Aging. 32: 548.e5-7. PMID 20034704 DOI: 10.1016/j.neurobiolaging.2009.11.020  1
2010 Singleton AB, Gibbs JR. Another locus, a new method. Brain : a Journal of Neurology. 133: 3492-3. PMID 21126992 DOI: 10.1093/brain/awq331  1
2010 Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, et al. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. American Journal of Human Genetics. 87: 890-7. PMID 21087763 DOI: 10.1016/j.ajhg.2010.11.002  1
2010 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Singleton AB, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/journal.pone.0013950  1
2010 Traynor BJ, Singleton AB. Nature versus nurture: death of a dogma, and the road ahead. Neuron. 68: 196-200. PMID 20955927 DOI: 10.1016/j.neuron.2010.10.002  1
2010 Johnson JO, Gibbs JR, Van Maldergem L, Houlden H, Singleton AB. Exome sequencing in Brown-Vialetto-van Laere syndrome. American Journal of Human Genetics. 87: 567-9; author reply . PMID 20920669 DOI: 10.1016/j.ajhg.2010.05.021  1
2010 Barr TL, Conley Y, Ding J, Dillman A, Warach S, Singleton A, Matarin M. Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling. Neurology. 75: 1009-14. PMID 20837969 DOI: 10.1212/WNL.0b013e3181f2b37f  1
2010 Singleton AB, Hardy J, Traynor BJ, Houlden H. Towards a complete resolution of the genetic architecture of disease. Trends in Genetics : Tig. 26: 438-42. PMID 20813421 DOI: 10.1016/j.tig.2010.07.004  1
2010 Tucci A, Nalls MA, Houlden H, Revesz T, Singleton AB, Wood NW, Hardy J, Paisán-Ruiz C. Genetic variability at the PARK16 locus. European Journal of Human Genetics : Ejhg. 18: 1356-9. PMID 20683486 DOI: 10.1038/ejhg.2010.125  1
2010 Paisán-Ruiz C, Guevara R, Federoff M, Hanagasi H, Sina F, Elahi E, Schneider SA, Schwingenschuh P, Bajaj N, Emre M, Singleton AB, Hardy J, Bhatia KP, Brandner S, Lees AJ, et al. Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 1791-800. PMID 20669327 DOI: 10.1002/mds.23221  1
2010 Kapur K, Johnson T, Beckmann ND, Sehmi J, Tanaka T, Kutalik Z, Styrkarsdottir U, Zhang W, Marek D, Gudbjartsson DF, Milaneschi Y, Holm H, Diiorio A, Waterworth D, Li Y, ... Singleton AB, et al. Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene. Plos Genetics. 6: e1001035. PMID 20661308 DOI: 10.1371/journal.pgen.1001035  1
2010 Biffi A, Anderson CD, Nalls MA, Rahman R, Sonni A, Cortellini L, Rost NS, Matarin M, Hernandez DG, Plourde A, de Bakker PI, Ross OA, Greenberg SM, Furie KL, Meschia JF, ... Singleton AB, et al. Principal-component analysis for assessment of population stratification in mitochondrial medical genetics. American Journal of Human Genetics. 86: 904-17. PMID 20537299 DOI: 10.1016/j.ajhg.2010.05.005  1
2010 Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, ... ... Singleton AB, et al. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Human Molecular Genetics. 19: 3295-301. PMID 20534741 DOI: 10.1093/hmg/ddq221  1
2010 Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, Arepalli S, Dillman A, Rafferty IP, Troncoso J, Johnson R, Zielke HR, Ferrucci L, Longo DL, Cookson MR, ... Singleton AB, et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. Plos Genetics. 6: e1000952. PMID 20485568 DOI: 10.1371/journal.pgen.1000952  1
2010 van de Leemput J, Wavrant-De Vrièze F, Rafferty I, Bras JM, Giunti P, Fisher EM, Hardy JA, Singleton AB, Houlden H. Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 771-3. PMID 20437544 DOI: 10.1002/mds.22970  1
2010 Eerola J, Luoma PT, Peuralinna T, Scholz S, Paisan-Ruiz C, Suomalainen A, Singleton AB, Tienari PJ. POLG1 polyglutamine tract variants associated with Parkinson's disease. Neuroscience Letters. 477: 1-5. PMID 20399836 DOI: 10.1016/j.neulet.2010.04.021  1
2010 Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, ... ... Singleton A, et al. New loci associated with kidney function and chronic kidney disease. Nature Genetics. 42: 376-84. PMID 20383146 DOI: 10.1038/ng.568  1
2010 Schorge S, van de Leemput J, Singleton A, Houlden H, Hardy J. Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling. Trends in Neurosciences. 33: 211-9. PMID 20226542 DOI: 10.1016/j.tins.2010.02.005  1
2010 Guerreiro RJ, Beck J, Gibbs JR, Santana I, Rossor MN, Schott JM, Nalls MA, Ribeiro H, Santiago B, Fox NC, Oliveira C, Collinge J, Mead S, Singleton A, Hardy J. Genetic variability in CLU and its association with Alzheimer's disease. Plos One. 5: e9510. PMID 20209083 DOI: 10.1371/journal.pone.0009510  1
2010 Wang C, Szpiech ZA, Degnan JH, Jakobsson M, Pemberton TJ, Hardy JA, Singleton AB, Rosenberg NA. Comparing spatial maps of human population-genetic variation using Procrustes analysis. Statistical Applications in Genetics and Molecular Biology. 9: Article 13. PMID 20196748 DOI: 10.2202/1544-6115.1493  1
2010 Matarin M, Singleton A, Hardy J, Meschia J. The genetics of ischaemic stroke. Journal of Internal Medicine. 267: 139-55. PMID 20175863 DOI: 10.1111/j.1365-2796.2009.02202.x  1
2010 Meilleur KG, Traoré M, Sangaré M, Britton A, Landouré G, Coulibaly S, Niaré B, Mochel F, La Pean A, Rafferty I, Watts C, Shriner D, Littleton-Kearney MT, Blackstone C, Singleton A, et al. Hereditary spastic paraplegia and amyotrophy associated with a novel locus on chromosome 19. Neurogenetics. 11: 313-8. PMID 20039086 DOI: 10.1007/s10048-009-0230-0  1
2010 Guerreiro RJ, Washecka N, Hardy J, Singleton A. A thorough assessment of benign genetic variability in GRN and MAPT. Human Mutation. 31: E1126-40. PMID 20020531 DOI: 10.1002/humu.21152  1
2010 Tanaka T, Roy CN, Yao W, Matteini A, Semba RD, Arking D, Walston JD, Fried LP, Singleton A, Guralnik J, Abecasis GR, Bandinelli S, Longo DL, Ferrucci L. A genome-wide association analysis of serum iron concentrations. Blood. 115: 94-6. PMID 19880490 DOI: 10.1182/blood-2009-07-232496  1
2010 Guerreiro RJ, Baquero M, Blesa R, Boada M, Brás JM, Bullido MJ, Calado A, Crook R, Ferreira C, Frank A, Gómez-Isla T, Hernández I, Lleó A, Machado A, Martínez-Lage P, ... ... Singleton A, et al. Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP. Neurobiology of Aging. 31: 725-31. PMID 18667258 DOI: 10.1016/j.neurobiolaging.2008.06.012  1
2009 Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, ... ... Singleton AB, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics. 41: 1308-12. PMID 19915575 DOI: 10.1038/ng.487  1
2009 Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T, Yang Q, Tanaka T, Jaffe A, ... ... Singleton AB, et al. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nature Genetics. 41: 1191-8. PMID 19862010 DOI: 10.1038/ng.466  1
2009 Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, Clark LN, Condroyer C, De Marco EV, Dürr A, ... ... Singleton A, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. The New England Journal of Medicine. 361: 1651-61. PMID 19846850 DOI: 10.1056/NEJMoa0901281  1
2009 Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Plos Genetics. 5: e1000685. PMID 19834535 DOI: 10.1371/journal.pgen.1000685  1
2009 Liu W, Ding J, Gibbs JR, Wang SJ, Hardy J, Singleton A. A simple and efficient algorithm for genome-wide homozygosity analysis in disease. Molecular Systems Biology. 5: 304. PMID 19756043 DOI: 10.1038/msb.2009.53  1
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Singleton AB, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/ng.440  1
2009 Matarin M, Brown WM, Dena H, Britton A, De Vrieze FW, Brott TG, Brown RD, Worrall BB, Case LD, Chanock SJ, Metter EJ, Ferruci L, Gamble D, Hardy JA, Rich SS, ... Singleton A, et al. Candidate gene polymorphisms for ischemic stroke. Stroke; a Journal of Cerebral Circulation. 40: 3436-42. PMID 19729601 DOI: 10.1161/STROKEAHA.109.558015  1
2009 Guerreiro RJ, Vaskov T, Crews C, Singleton A, Hardy J. A case of dementia with PRNP D178Ncis-129M and no insomnia. Alzheimer Disease and Associated Disorders. 23: 415-7. PMID 19571725 DOI: 10.1097/WAD.0b013e3181ae3a76  1
2009 Bucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, Sonnenblick LI, Alvarez Retuerto AI, Imielinski M, Hadley D, Bradfield JP, Kim C, Gidaya NB, Lindquist I, Hutman T, Sigman M, ... ... Singleton A, et al. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. Plos Genetics. 5: e1000536. PMID 19557195 DOI: 10.1371/journal.pgen.1000536  1
2009 Paisán-Ruiz C, Washecka N, Nath P, Singleton AB, Corder EH. Parkinson's disease and low frequency alleles found together throughout LRRK2. Annals of Human Genetics. 73: 391-403. PMID 19489756 DOI: 10.1111/j.1469-1809.2009.00524.x  1
2009 Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, ... ... Singleton AB, et al. SNCA variants are associated with increased risk for multiple system atrophy. Annals of Neurology. 65: 610-4. PMID 19475667 DOI: 10.1002/ana.21685  1
2009 Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, ... ... Singleton A, et al. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics. 41: 648-50. PMID 19448620 DOI: 10.1038/ng.386  1
2009 Traynor BJ, Singleton AB. What's the FUS! The Lancet. Neurology. 8: 418-9. PMID 19375659 DOI: 10.1016/S1474-4422(09)70088-2  1
2009 Duncan AJ, Bitner-Glindzicz M, Meunier B, Costello H, Hargreaves IP, López LC, Hirano M, Quinzii CM, Sadowski MI, Hardy J, Singleton A, Clayton PT, Rahman S. A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease. American Journal of Human Genetics. 84: 558-66. PMID 19375058 DOI: 10.1016/j.ajhg.2009.03.018  1
2009 Hardy J, Singleton A. Genomewide association studies and human disease. The New England Journal of Medicine. 360: 1759-68. PMID 19369657 DOI: 10.1056/NEJMra0808700  1
2009 Brooks J, Ding J, Simon-Sanchez J, Paisan-Ruiz C, Singleton AB, Scholz SW. Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control. Journal of Medical Genetics. 46: 375-81. PMID 19351622 DOI: 10.1136/jmg.2008.063917  1
2009 Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, Lai S, Mulas A, Corsi AM, Vestrini A, Sofi F, Gori AM, Abbate R, Guralnik J, Singleton A, et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. American Journal of Human Genetics. 84: 477-82. PMID 19303062 DOI: 10.1016/j.ajhg.2009.02.011  1
2009 Neumann J, Bras J, Deas E, O'Sullivan SS, Parkkinen L, Lachmann RH, Li A, Holton J, Guerreiro R, Paudel R, Segarane B, Singleton A, Lees A, Hardy J, Houlden H, et al. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain : a Journal of Neurology. 132: 1783-94. PMID 19286695 DOI: 10.1093/brain/awp044  1
2009 Nalls MA, Simon-Sanchez J, Gibbs JR, Paisan-Ruiz C, Bras JT, Tanaka T, Matarin M, Scholz S, Weitz C, Harris TB, Ferrucci L, Hardy J, Singleton AB. Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics. Plos Genetics. 5: e1000415. PMID 19282984 DOI: 10.1371/journal.pgen.1000415  1
2009 Nalls MA, Guerreiro RJ, Simon-Sanchez J, Bras JT, Traynor BJ, Gibbs JR, Launer L, Hardy J, Singleton AB. Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease. Neurogenetics. 10: 183-90. PMID 19271249 DOI: 10.1007/s10048-009-0182-4  1
2009 Huang L, Li Y, Singleton AB, Hardy JA, Abecasis G, Rosenberg NA, Scheet P. Genotype-imputation accuracy across worldwide human populations. American Journal of Human Genetics. 84: 235-50. PMID 19215730 DOI: 10.1016/j.ajhg.2009.01.013  1
2009 Camargos ST, Dornas LO, Momeni P, Lees A, Hardy J, Singleton A, Cardoso F. Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 662-6. PMID 19205068 DOI: 10.1002/mds.22365  1
2009 Defazio G, Matarin M, Peckham EL, Martino D, Valente EM, Singleton A, Crawley A, Aniello MS, Brancati F, Abbruzzese G, Girlanda P, Livrea P, Hallett M, Berardelli A. The TOR1A polymorphism rs1182 and the risk of spread in primary blepharospasm. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 613-6. PMID 19202559 DOI: 10.1002/mds.22471  1
2009 Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, ... ... Singleton A, et al. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Human Molecular Genetics. 18: 1524-32. PMID 19193627 DOI: 10.1093/hmg/ddp059  1
2009 Ferrucci L, Perry JR, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried LP, Albanes D, Corsi AM, Cherubini A, Guralnik J, ... ... Singleton A, et al. Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. American Journal of Human Genetics. 84: 123-33. PMID 19185284 DOI: 10.1016/j.ajhg.2008.12.019  1
2009 Bronstein J, Carvey P, Chen H, Cory-Slechta D, DiMonte D, Duda J, English P, Goldman S, Grate S, Hansen J, Hoppin J, Jewell S, Kamel F, Koroshetz W, Langston JW, ... ... Singleton A, et al. Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007. Environmental Health Perspectives. 117: 117-21. PMID 19165397 DOI: 10.1289/ehp.11702  1
2009 Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, Guralnik JM, Singleton A, Bandinelli S, Cherubini A, Arnett D, Tsai MY, Ferrucci L. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. Plos Genetics. 5: e1000338. PMID 19148276 DOI: 10.1371/journal.pgen.1000338  1
2009 Bras JM, Singleton A. Genetic susceptibility in Parkinson's disease. Biochimica Et Biophysica Acta. 1792: 597-603. PMID 19063963 DOI: 10.1016/j.bbadis.2008.11.008  1
2009 Wickremaratchi MM, Majounie E, Morris HR, Williams NM, Lewis H, Gill SS, Khan S, Heywood P, Hardy J, Wiles CM, Singleton AB, Quinn NP. Parkin-related disease clinically diagnosed as a pallido-pyramidal syndrome. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 138-40. PMID 18942080 DOI: 10.1002/mds.22181  1
2009 Bras J, Simón-Sánchez J, Federoff M, Morgadinho A, Januario C, Ribeiro M, Cunha L, Oliveira C, Singleton AB. Lack of replication of association between GIGYF2 variants and Parkinson disease. Human Molecular Genetics. 18: 341-6. PMID 18923002 DOI: 10.1093/hmg/ddn340  1
2009 Paisan-Ruiz C, Bhatia KP, Li A, Hernandez D, Davis M, Wood NW, Hardy J, Houlden H, Singleton A, Schneider SA. Characterization of PLA2G6 as a locus for dystonia-parkinsonism. Annals of Neurology. 65: 19-23. PMID 18570303 DOI: 10.1002/ana.21415  1
2009 Clarimón J, Djaldetti R, Lleó A, Guerreiro RJ, Molinuevo JL, Paisán-Ruiz C, Gómez-Isla T, Blesa R, Singleton A, Hardy J. Whole genome analysis in a consanguineous family with early onset Alzheimer's disease. Neurobiology of Aging. 30: 1986-91. PMID 18387709 DOI: 10.1016/j.neurobiolaging.2008.02.008  1
2009 Bras J, Paisan-Ruiz C, Guerreiro R, Ribeiro MH, Morgadinho A, Januario C, Sidransky E, Oliveira C, Singleton A. Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Portugal. Neurobiology of Aging. 30: 1515-7. PMID 18160183 DOI: 10.1016/j.neurobiolaging.2007.11.016  1
2008 Bras J, Singleton A, Cookson MR, Hardy J. Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease. The Febs Journal. 275: 5767-73. PMID 19021754 DOI: 10.1111/j.1742-4658.2008.06709.x  1
2008 Timmons MM, Garbern J, Robey PG, Singleton A, Hernandez DG, Roodman GD, Zaltz I, Mumm S, Wilcox W, Fischbeck KH, Brady RO, Knight MA. WITHDRAWN: Familial Degenerative Encephalopathy with Intracranial Calcification and Metaphyseal Dysplasia. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 19016590 DOI: 10.1359/jbmr.081110  0.52
2008 Simón-Sánchez J, Singleton A. Genome-wide association studies in neurological disorders. The Lancet. Neurology. 7: 1067-72. PMID 18940696 DOI: 10.1016/S1474-4422(08)70241-2  1
2008 Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, Bergmann S, Beckmann ND, Li Y, Ferrucci L, Melzer D, ... ... Singleton A, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. American Journal of Human Genetics. 83: 520-8. PMID 18940312 DOI: 10.1016/j.ajhg.2008.09.012  1
2008 Okubadejo N, Britton A, Crews C, Akinyemi R, Hardy J, Singleton A, Bras J. Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3. Plos One. 3: e3421. PMID 18927607 DOI: 10.1371/journal.pone.0003421  1
2008 Ludlow CL, Adler CH, Berke GS, Bielamowicz SA, Blitzer A, Bressman SB, Hallett M, Jinnah HA, Juergens U, Martin SB, Perlmutter JS, Sapienza C, Singleton A, Tanner CM, Woodson GE. Research priorities in spasmodic dysphonia. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 139: 495-505. PMID 18922334 DOI: 10.1016/j.otohns.2008.05.624  1
2008 Knight MA, Hernandez D, Diede SJ, Dauwerse HG, Rafferty I, van de Leemput J, Forrest SM, Gardner RJ, Storey E, van Ommen GJ, Tapscott SJ, Fischbeck KH, Singleton AB. A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20. Human Molecular Genetics. 17: 3847-53. PMID 18801880 DOI: 10.1093/hmg/ddn283  1
2008 Paisan-Ruiz C, Nath P, Wood NW, Singleton A, Houlden H. Clinical heterogeneity and genotype-phenotype correlations in hereditary spastic paraplegia because of Spatacsin mutations (SPG11). European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 15: 1065-70. PMID 18717728 DOI: 10.1111/j.1468-1331.2008.02247.x  0.76
2008 Bandmann O, Singleton AB. Yet another spinocerebellar ataxia: the saga continues. Neurology. 71: 542-3. PMID 18711106 DOI: 10.1212/01.wnl.0000323932.90720.55  1
2008 Peuralinna T, Oinas M, Polvikoski T, Paetau A, Sulkava R, Niinistö L, Kalimo H, Hernandez D, Hardy J, Singleton A, Tienari PJ, Myllykangas L. Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein. Annals of Neurology. 64: 348-52. PMID 18661559 DOI: 10.1002/ana.21446  1
2008 Singleton A, Morris H. Association, expression, pathobiology: is too much tau in PD a blueprint for genetic association? Neurology. 71: 11-2. PMID 18591501 DOI: 10.1212/01.wnl.0000316388.84840.1f  1
2008 Guerreiro RJ, Schymick JC, Crews C, Singleton A, Hardy J, Traynor BJ. TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis. Plos One. 3: e2450. PMID 18545701 DOI: 10.1371/journal.pone.0002450  1
2008 Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JR, Weedon MN, Singleton A, Hernandez D, Evans J, Durant C, Ferrucci L, Melzer D, Saravanan P, Visser TJ, et al. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. The Journal of Clinical Endocrinology and Metabolism. 93: 3075-81. PMID 18492748 DOI: 10.1210/jc.2008-0397  0.48
2008 Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, Rafiq S, Simon-Sanchez J, Lango H, Scholz S, Weedon MN, ... ... Singleton A, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). Plos Genetics. 4: e1000072. PMID 18464913 DOI: 10.1371/journal.pgen.1000072  1
2008 Guerreiro RJ, Santana I, Bras JM, Revesz T, Rebelo O, Ribeiro MH, Santiago B, Oliveira CR, Singleton A, Hardy J. Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 1269-73. PMID 18464284 DOI: 10.1002/mds.22078  1
2008 Pchelina SN, Yakimovskii AF, Emelyanov AK, Ivanova ON, Schwarzman AL, Singleton AB. Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 15: 692-6. PMID 18435766 DOI: 10.1111/j.1468-1331.2008.02149.x  1
2008 Xiromerisiou G, Hadjigeorgiou GM, Papadimitriou A, Katsarogiannis E, Gourbali V, Singleton AB. Association between AKT1 gene and Parkinson's disease: a protective haplotype. Neuroscience Letters. 436: 232-4. PMID 18395980 DOI: 10.1016/j.neulet.2008.03.026  1
2008 Tanskanen M, Peuralinna T, Polvikoski T, Notkola IL, Sulkava R, Hardy J, Singleton A, Kiuru-Enari S, Paetau A, Tienari PJ, Myllykangas L. Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. Annals of Medicine. 40: 232-9. PMID 18382889 DOI: 10.1080/07853890701842988  1
2008 Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, ... ... Singleton AB, et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (New York, N.Y.). 320: 539-43. PMID 18369103 DOI: 10.1126/science.1155174  1
2008 Simón-Sánchez J, Singleton AB. Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls. Human Molecular Genetics. 17: 1988-93. PMID 18364387 DOI: 10.1093/hmg/ddn096  1
2008 Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF. Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21. Stroke; a Journal of Cerebral Circulation. 39: 1586-9. PMID 18340101 DOI: 10.1161/STROKEAHA.107.502963  1
2008 Paisan-Ruiz C, Dogu O, Yilmaz A, Houlden H, Singleton A. SPG11 mutations are common in familial cases of complicated hereditary spastic paraplegia. Neurology. 70: 1384-9. PMID 18337587 DOI: 10.1212/01.wnl.0000294327.66106.3d  0.76
2008 Hardy J, Singleton A. The HapMap: charting a course for genetic discovery in neurological diseases. Archives of Neurology. 65: 319-21. PMID 18332243 DOI: 10.1001/archneur.65.3.319  1
2008 Scholz S, Singleton A. Susceptibility genes in movement disorders. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 927-34; quiz 1064. PMID 18311830 DOI: 10.1002/mds.21983  1
2008 Mochel F, Knight MA, Tong WH, Hernandez D, Ayyad K, Taivassalo T, Andersen PM, Singleton A, Rouault TA, Fischbeck KH, Haller RG. Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance. American Journal of Human Genetics. 82: 652-60. PMID 18304497 DOI: 10.1016/j.ajhg.2007.12.012  1
2008 Matarin M, Simon-Sanchez J, Fung HC, Scholz S, Gibbs JR, Hernandez DG, Crews C, Britton A, De Vrieze FW, Brott TG, Brown RD, Worrall BB, Silliman S, Case LD, Hardy JA, ... ... Singleton AB, et al. Structural genomic variation in ischemic stroke. Neurogenetics. 9: 101-8. PMID 18288507 DOI: 10.1007/s10048-008-0119-3  1
2008 Jakobsson M, Scholz SW, Scheet P, Gibbs JR, VanLiere JM, Fung HC, Szpiech ZA, Degnan JH, Wang K, Guerreiro R, Bras JM, Schymick JC, Hernandez DG, Traynor BJ, Simon-Sanchez J, ... ... Singleton AB, et al. Genotype, haplotype and copy-number variation in worldwide human populations. Nature. 451: 998-1003. PMID 18288195 DOI: 10.1038/nature06742  1
2008 Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, ... Singleton AB, et al. DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA. The Lancet. Neurology. 7: 207-15. PMID 18243799 DOI: 10.1016/S1474-4422(08)70022-X  1
2008 Paisán-Ruíz C, Nath P, Washecka N, Gibbs JR, Singleton AB. Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. Human Mutation. 29: 485-90. PMID 18213618 DOI: 10.1002/humu.20668  1
2008 Bras J, Guerreiro R, Ribeiro M, Morgadinho A, Januario C, Dias M, Calado A, Semedo C, Oliveira C, Hardy J, Singleton A. Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2. Bmc Neurology. 8: 1. PMID 18211709 DOI: 10.1186/1471-2377-8-1  1
2008 Clarimón J, Pagonabarraga J, Paisán-Ruíz C, Campolongo A, Pascual-Sedano B, Martí-Massó JF, Singleton AB, Kulisevsky J. Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 518-23. PMID 18098275 DOI: 10.1002/mds.21771  1
2008 Camargos ST, Cardoso F, Momeni P, Gianetti JG, Lees A, Hardy J, Singleton A. Novel GCH1 mutation in a Brazilian family with dopa-responsive dystonia. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 299-302. PMID 18044725 DOI: 10.1002/mds.21842  1
2008 Simon-Sanchez J, Scholz S, Matarin Mdel M, Fung HC, Hernandez D, Gibbs JR, Britton A, Hardy J, Singleton A. Genomewide SNP assay reveals mutations underlying Parkinson disease. Human Mutation. 29: 315-22. PMID 17994548 DOI: 10.1002/humu.20626  1
2008 Hardy J, Low N, Singleton A. Whole genome association studies: deciding when persistence becomes perseveration. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 131-3. PMID 17541974 DOI: 10.1002/ajmg.b.30568  1
2008 Matarin M, Brown WM, Hardy JA, Rich SS, Singleton AB, Brown RD, Brott TG, Worrall BB, Meschia JF. Association of integrin alpha2 gene variants with ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 81-9. PMID 17534386 DOI: 10.1038/sj.jcbfm.9600508  1
2007 Greggio E, Singleton A. Kinase signaling pathways as potential targets in the treatment of Parkinson's disease. Expert Review of Proteomics. 4: 783-92. PMID 18067416 DOI: 10.1586/14789450.4.6.783  1
2007 Gwinn K, Corriveau RA, Mitsumoto H, Bednarz K, Brown RH, Cudkowicz M, Gordon PH, Hardy J, Kasarskis EJ, Kaufmann P, Miller R, Sorenson E, Tandan R, Traynor BJ, Nash J, ... ... Singleton A, et al. Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery. Plos One. 2: e1254. PMID 18060051 DOI: 10.1371/journal.pone.0001254  1
2007 Houlden H, Johnson J, Gardner-Thorpe C, Lashley T, Hernandez D, Worth P, Singleton AB, Hilton DA, Holton J, Revesz T, Davis MB, Giunti P, Giunti P, Wood NW. Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nature Genetics. 39: 1434-6. PMID 18037885 DOI: 10.1038/ng.2007.43  1
2007 Traynor BJ, Singleton A. Genome-wide association studies and ALS: are we there yet? The Lancet. Neurology. 6: 841-3. PMID 17884667 DOI: 10.1016/S1474-4422(07)70225-9  1
2007 Goldstein DS, Imrich R, Peckham E, Holmes C, Lopez G, Crews C, Hardy J, Singleton A, Hallett M. Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation. Neurology. 69: 1580-4. PMID 17625107 DOI: 10.1212/01.wnl.0000268696.57912.64  1
2007 Johnson J, Paisán-Ruíz C, Lopez G, Crews C, Britton A, Malkani R, Evans EW, McInerney-Leo A, Jain S, Nussbaum RL, Foote KD, Mandel RJ, Crawley A, Reimsnider S, Fernandez HH, ... ... Singleton AB, et al. Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation. Neuro-Degenerative Diseases. 4: 386-91. PMID 17622782 DOI: 10.1159/000105160  1
2007 Hardy J, Singleton A. Reporting and interpretation of genetic variants in cases and controls. Neurology. 69: 111-2. PMID 17606889 DOI: 10.1212/01.wnl.0000265059.56575.a6  1
2007 van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, ... ... Singleton AB, et al. Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. Plos Genetics. 3: e108. PMID 17590087 DOI: 10.1371/journal.pgen.0030108  1
2007 Lees AJ, Singleton AB. Clinical heterogeneity of ATP13A2 linked disease (Kufor-Rakeb) justifies a PARK designation. Neurology. 68: 1553-4. PMID 17485640 DOI: 10.1212/01.wnl.0000265228.66664.f4  1
2007 Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, ... ... Singleton A, et al. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. The Lancet. Neurology. 6: 414-20. PMID 17434096 DOI: 10.1016/S1474-4422(07)70081-9  1
2007 Clarimon J, Gray RR, Williams LN, Enoch MA, Robin RW, Albaugh B, Singleton A, Goldman D, Mulligan CJ. Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. Alcoholism, Clinical and Experimental Research. 31: 546-54. PMID 17374033 DOI: 10.1111/j.1530-0277.2007.00338.x  1
2007 Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, ... ... Singleton AB, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/jnnp.2006.109553  1
2007 Schymick JC, Scholz SW, Fung HC, Britton A, Arepalli S, Gibbs JR, Lombardo F, Matarin M, Kasperaviciute D, Hernandez DG, Crews C, Bruijn L, Rothstein J, Mora G, Restagno G, ... ... Singleton A, et al. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. The Lancet. Neurology. 6: 322-8. PMID 17362836 DOI: 10.1016/S1474-4422(07)70037-6  1
2007 Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, ... ... Singleton AB, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 68: 812-9. PMID 17353469 DOI: 10.1212/01.wnl.0000256715.13907.d3  1
2007 Worrall BB, Brott TG, Brown RD, Brown WM, Rich SS, Arepalli S, Wavrant-De Vrièze F, Duckworth J, Singleton AB, Hardy J, Meschia JF. IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations. Stroke; a Journal of Cerebral Circulation. 38: 1189-96. PMID 17332449 DOI: 10.1161/01.STR.0000260099.42744.b0  1
2007 Wiklund PG, Brown WM, Brott TG, Stegmayr B, Brown RD, Nilsson-Ardnor S, Hardy JA, Kissela BM, Singleton A, Holmberg D, Rich SS, Meschia JF. Lack of aggregation of ischemic stroke subtypes within affected sibling pairs. Neurology. 68: 427-31. PMID 17283317 DOI: 10.1212/01.wnl.0000252955.17126.6a  1
2007 Kovac IP, Havlik RJ, Foley D, Peila R, Hernandez D, Wavrant-De Vrièze F, Singleton A, Egan J, Taub D, Rodriguez B, Masaki K, Curb JD, Fujimoto WY, Wilson AF. Linkage and association analyses of type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese Americans from Hawaii. Diabetes. 56: 537-40. PMID 17259404 DOI: 10.2337/db06-0443  1
2007 Low N, Singleton A. Establishing the genetic heterogeneity of familial hemiplegic migraine. Brain : a Journal of Neurology. 130: 312-3. PMID 17235123 DOI: 10.1093/brain/awl381  1
2007 Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun MS, Tienari PJ, Singleton AB. BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. Neuroscience Letters. 415: 59-63. PMID 17229524 DOI: 10.1016/j.neulet.2006.12.038  1
2007 Xiromerisiou G, Hadjigeorgiou GM, Gourbali V, Johnson J, Papakonstantinou I, Papadimitriou A, Singleton AB. Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 14: 7-11. PMID 17222106 DOI: 10.1111/j.1468-1331.2006.01551.x  1
2007 Clarimon J, Brancati F, Peckham E, Valente EM, Dallapiccola B, Abruzzese G, Girlanda P, Defazio G, Berardelli A, Hallett M, Singleton AB. Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 162-6. PMID 17133500 DOI: 10.1002/mds.21182  1
2007 Simon-Sanchez J, Scholz S, Fung HC, Matarin M, Hernandez D, Gibbs JR, Britton A, de Vrieze FW, Peckham E, Gwinn-Hardy K, Crawley A, Keen JC, Nash J, Borgaonkar D, Hardy J, ... Singleton A, et al. Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals. Human Molecular Genetics. 16: 1-14. PMID 17116639 DOI: 10.1093/hmg/ddl436  1
2007 Hanagasi HA, Lees A, Johnson JO, Singleton A, Emre M. Smoking-responsive juvenile-onset Parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 115-9. PMID 17080433 DOI: 10.1002/mds.21177  1
2006 Fung HC, Xiromerisiou G, Gibbs JR, Wu YR, Eerola J, Gourbali V, Hellström O, Chen CM, Duckworth J, Papadimitriou A, Tienari PJ, Hadjigeorgiou GM, Hardy J, Singleton AB. Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts. Neuro-Degenerative Diseases. 3: 327-33. PMID 17192721 DOI: 10.1159/000097301  1
2006 Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR. A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan. Bmc Neurology. 6: 47. PMID 17187665 DOI: 10.1186/1471-2377-6-47  1
2006 Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, ... ... Singleton A, et al. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Bmc Neurology. 6: 44. PMID 17166276 DOI: 10.1186/1471-2377-6-44  1
2006 Scholz S, Mandel RJ, Fernandez HH, Foote KD, Rodriguez RL, Barton E, Munson S, Singleton A, Okun MS. LRRK2 mutations in a clinic-based cohort of Parkinson's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 13: 1298-301. PMID 17116211 DOI: 10.1111/j.1468-1331.2006.01472.x  1
2006 Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A. Genetics of Parkinson's disease and parkinsonism. Annals of Neurology. 60: 389-98. PMID 17068789 DOI: 10.1002/ana.21022  1
2006 Fung HC, Scholz S, Matarin M, Simón-Sánchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, Okun MS, Mandel RJ, Fernandez HH, Foote KD, Rodríguez RL, ... ... Singleton A, et al. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. The Lancet. Neurology. 5: 911-6. PMID 17052657 DOI: 10.1016/S1474-4422(06)70578-6  1
2006 Gibbs JR, Singleton A. Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. Plos Genetics. 2: e150. PMID 17029559 DOI: 10.1371/journal.pgen.0020150  1
2006 Guerreiro RJ, Bras JM, Santana I, Januario C, Santiago B, Morgadinho AS, Ribeiro MH, Hardy J, Singleton A, Oliveira C. Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. Bmc Neurology. 6: 24. PMID 16824219 DOI: 10.1186/1471-2377-6-24  1
2005 Bras JM, Guerreiro RJ, Ribeiro MH, Januario C, Morgadinho A, Oliveira CR, Cunha L, Hardy J, Singleton A. G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 1653-5. PMID 16149095 DOI: 10.1002/mds.20682  1
Show low-probability matches.