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Mark R. Cookson, PhD, University of Salford 1995 - Publications

Cell Biology and Gene Expression National Institute of Aging, Cabanatuan City, Central Luzon, Philippines 

232 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Soutar MPM, Melandri D, O'Callaghan B, Annuario E, Monaghan AE, Welsh NJ, D'Sa K, Guelfi S, Zhang D, Pittman A, Trabzuni D, Verboven AHA, Pan KS, Kia DA, Bictash M, ... ... Cookson MR, et al. Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Brain : a Journal of Neurology. PMID 36074904 DOI: 10.1093/brain/awac325  0.6
2022 Langston RG, Beilina A, Reed X, Kaganovich A, Singleton AB, Blauwendraat C, Gibbs JR, Cookson MR. Association of a common genetic variant with Parkinson's disease is mediated by microglia. Science Translational Medicine. 14: eabp8869. PMID 35895835 DOI: 10.1126/scitranslmed.abp8869  0.55
2022 Kedariti M, Frattini E, Baden P, Cogo S, Civiero L, Ziviani E, Zilio G, Bertoli F, Aureli M, Kaganovich A, Cookson MR, Stefanis L, Surface M, Deleidi M, Di Fonzo A, et al. LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease. Npj Parkinson's Disease. 8: 92. PMID 35853899 DOI: 10.1038/s41531-022-00354-3  0.383
2022 Fernández B, Chittoor-Vinod VG, Kluss JH, Kelly K, Bryant N, Nguyen APT, Bukhari SA, Smith N, Lara Ordóñez AJ, Fdez E, Chartier-Harlin MC, Montine TJ, Wilson MA, Moore DJ, West AB, ... Cookson MR, et al. Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity. Journal of Parkinson's Disease. PMID 35599495 DOI: 10.3233/JPD-213128  0.612
2021 Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, ... ... Cookson MR, et al. Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. Plos Biology. 19: e3001480. PMID 34914695 DOI: 10.1371/journal.pbio.3001480  0.354
2021 Nalls MA, Blauwendraat C, Sargent L, Vitale D, Leonard H, Iwaki H, Song Y, Bandres-Ciga S, Menden K, Faghri F, Heutink P, Cookson MR, Singleton AB. Evidence for connecting multiple neurodegenerative diseases. Brain Communications. 3: fcab095. PMID 34693284 DOI: 10.1093/braincomms/fcab095  0.5
2021 Lake J, Reed X, Langston RG, Nalls MA, Gan-Or Z, Cookson MR, Singleton AB, Blauwendraat C, Leonard HL. Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34542912 DOI: 10.1002/mds.28787  0.517
2021 Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, et al. Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. Jama Neurology. PMID 34459874 DOI: 10.1001/jamaneurol.2021.2598  0.466
2021 Mazza MC, Beilina A, Roosen DA, Hauser D, Cookson MR. Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation. Stem Cell Research. 55: 102506. PMID 34419745 DOI: 10.1016/j.scr.2021.102506  0.718
2021 Bonet-Ponce L, Cookson MR. LRRK2 recruitment, activity, and function in organelles. The Febs Journal. PMID 34196120 DOI: 10.1111/febs.16099  0.37
2021 Beylina A, Langston RG, Rosen D, Reed X, Cookson MR. Generation of fourteen isogenic cell lines for Parkinson's disease-associated leucine-rich repeat kinase (LRRK2). Stem Cell Research. 53: 102354. PMID 34087985 DOI: 10.1016/j.scr.2021.102354  0.353
2021 Lai D, Alipanahi B, Fontanillas P, Schwantes-An TH, Aasly J, Alcalay RN, Beecham GW, Berg D, Bressman S, Brice A, Brockman K, Clark L, Cookson M, Das S, Van Deerlin V, et al. Genome-wide association studies of LRRK2 modifiers of Parkinson's disease. Annals of Neurology. PMID 33938021 DOI: 10.1002/ana.26094  0.542
2021 Ramos DM, Skarnes WC, Singleton AB, Cookson MR, Ward ME. Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH. Neuron. 109: 1080-1083. PMID 33831364 DOI: 10.1016/j.neuron.2021.03.022  0.436
2021 Kluss JH, Mazza MC, Li Y, Manzoni C, Lewis PA, Cookson MR, Mamais A. Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo. Molecular Neurodegeneration. 16: 17. PMID 33741046 DOI: 10.1186/s13024-021-00441-8  0.344
2021 Landeck N, Conti Mazza M, Duffy M, Bishop C, Sortwell CE, Cookson MR. Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease. Journal of Visualized Experiments : Jove. PMID 33682858 DOI: 10.3791/62128  0.771
2021 Mazza MC, Nguyen V, Beilina A, Karakoleva E, Coyle M, Ding J, Bishop C, Cookson MR. Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo. Journal of Parkinson's Disease. PMID 33523017 DOI: 10.3233/JPD-202172  0.391
2020 Bonet-Ponce L, Beilina A, Williamson CD, Lindberg E, Kluss JH, Saez-Atienzar S, Landeck N, Kumaran R, Mamais A, Bleck CKE, Li Y, Cookson MR. LRRK2 mediates tubulation and vesicle sorting from lysosomes. Science Advances. 6. PMID 33177079 DOI: 10.1126/sciadv.abb2454  0.301
2020 Kim C, Beilina A, Smith N, Li Y, Kim M, Kumaran R, Kaganovich A, Mamais A, Adame A, Iba M, Kwon S, Lee WJ, Shin SJ, Rissman RA, You S, ... ... Cookson MR, et al. LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies. Science Translational Medicine. 12. PMID 33055242 DOI: 10.1126/scitranslmed.aay0399  0.456
2020 Filippini A, Mutti V, Faustini G, Longhena F, Ramazzina I, Rizzi F, Kaganovich A, Roosen DA, Landeck N, Duffy M, Tessari I, Bono F, Fiorentini C, Greggio E, Bubacco L, ... ... Cookson MR, et al. Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes. Glia. PMID 33045109 DOI: 10.1002/glia.23920  0.72
2020 Bandres-Ciga S, Saez-Atienzar S, Kim JJ, Makarious MB, Faghri F, Diez-Fairen M, Iwaki H, Leonard H, Botia J, Ryten M, Hernandez D, Gibbs JR, Ding J, Gan-Or Z, Noyce A, ... ... Cookson M, et al. Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease. Acta Neuropathologica. PMID 32601912 DOI: 10.1007/S00401-020-02181-3  0.466
2020 Heaton GR, Landeck N, Mamais A, Nalls MA, Nixon-Abell J, Kumaran R, Beilina A, Pelligrini L, Li Y, Harvey K, Cookson MR. Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis. Neurobiology of Disease. 104948. PMID 32434048 DOI: 10.1016/J.Nbd.2020.104948  0.507
2020 Bonet-Ponce PhD L, Cookson MR. Can Leucine-Rich Repeat Kinase 2 Inhibition Benefit GBA-Parkinson's Disease? Movement Disorders : Official Journal of the Movement Disorder Society. 35: 721-723. PMID 32415718 DOI: 10.1002/Mds.28029  0.398
2020 Beilina A, Bonet-Ponce L, Kumaran R, Kordich JJ, Ishida M, Mamais A, Kaganovich A, Saez-Atienzar S, Gershlick DC, Roosen DA, Pellegrini L, Malkov V, Fell MJ, Harvey K, Bonifacino JS, ... ... Cookson MR, et al. The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network. Cell Reports. 31: 107614. PMID 32375042 DOI: 10.1016/J.Celrep.2020.107614  0.476
2020 Langston RG, Cookson MR. Pathways of protein synthesis and degradation in PD pathogenesis. Progress in Brain Research. 252: 217-270. PMID 32247365 DOI: 10.1016/Bs.Pbr.2020.01.002  0.423
2020 Area-Gomez E, Larrea D, Pera M, Agrawal RR, Guilfoyle DN, Pirhaji L, Shannon K, Arain HA, Ashok A, Chen Q, Dillman AA, Figueroa HY, Cookson MR, Gross SS, Fraenkel E, et al. APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice. Scientific Reports. 10: 4277. PMID 32152337 DOI: 10.1038/S41598-020-61142-8  0.523
2020 Vermilyea SC, Babinski A, Tran N, To S, Guthrie S, Kluss JH, Schmidt JK, Wiepz GJ, Meyer MG, Murphy ME, Cookson MR, Emborg ME, Golos TG. In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets. Scientific Reports. 10: 3447. PMID 32103062 DOI: 10.1038/S41598-020-60273-2  0.448
2019 Rovini A, Gurnev PA, Beilina A, Queralt-Martín M, Rosencrans W, Cookson MR, Bezrukov SM, Rostovtseva TK. Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC. Cellular and Molecular Life Sciences : Cmls. PMID 31760463 DOI: 10.1007/S00018-019-03386-W  0.345
2019 Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, ... ... Cookson MR, et al. Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain : a Journal of Neurology. PMID 31755958 DOI: 10.1093/Brain/Awz350  0.628
2019 Roosen DA, Blauwendraat C, Cookson MR, Lewis PA. DNAJC proteins and pathways to parkinsonism. The Febs Journal. PMID 31120186 DOI: 10.1111/Febs.14936  0.465
2019 Russo I, Kaganovich A, Ding J, Landeck N, Mamais A, Varanita T, Biosa A, Tessari I, Bubacco L, Greggio E, Cookson MR. Transcriptase analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils. Neurobiology of Disease. PMID 31102768 DOI: 10.1016/J.Nbd.2019.05.012  0.617
2019 Bonet-Ponce L, Cookson MR. The role of Rab GTPases in the pathobiology of Parkinson' disease. Current Opinion in Cell Biology. 59: 73-80. PMID 31054512 DOI: 10.1016/J.Ceb.2019.03.009  0.44
2019 Li Y, Cookson MR. Proteomics; applications in familial Parkinson's disease. Journal of Neurochemistry. PMID 31022302 DOI: 10.1111/Jnc.14708  0.463
2019 Tremblay ME, Cookson MR, Civiero L. Glial phagocytic clearance in Parkinson's disease. Molecular Neurodegeneration. 14: 16. PMID 30953527 DOI: 10.1186/S13024-019-0314-8  0.446
2019 Kluss JH, Mamais A, Cookson MR. LRRK2 links genetic and sporadic Parkinson's disease. Biochemical Society Transactions. PMID 30837320 DOI: 10.1042/Bst20180462  0.49
2019 Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, et al. Assessment of APOE in atypical parkinsonism syndromes. Neurobiology of Disease. PMID 30798004 DOI: 10.1016/J.Nbd.2019.02.016  0.352
2019 Wu CX, Liao J, Park Y, Reed X, Engel VA, Hoang NC, Takagi Y, Johnson SM, Wang M, Federici M, Nichols RJ, Sanishvili R, Cookson MR, Hoang QQ. Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. The Journal of Biological Chemistry. PMID 30796162 DOI: 10.1074/Jbc.Ra119.007631  0.424
2019 Bandres-Ciga S, Saez-Atienzar S, Bonet-Ponce L, Billingsley K, Vitale D, Blauwendraat C, Gibbs JR, Pihlstrøm L, Gan-Or Z, Cookson MR, Nalls MA, Singleton AB. The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30675927 DOI: 10.1002/Mds.27614  0.543
2019 Kim C, You S, Rissman R, Lee S, Singleton A, Cookson M, Masliah E. LRRK2 regulates microglial neurotoxicity via NFATc2 in synucleinopathies Ibro Reports. 6: S488. DOI: 10.1016/J.Ibror.2019.07.1532  0.47
2018 Blauwendraat C, Pletnikova O, Geiger JT, Murphy NA, Abramzon Y, Rudow G, Mamais A, Sabir MS, Crain B, Ahmed S, Rosenthal LS, Bakker CC, Faghri F, Chia R, Ding J, ... ... Cookson MR, et al. Genetic analysis of neurodegenerative diseases in a pathology cohort. Neurobiology of Aging. PMID 30528841 DOI: 10.1016/J.Neurobiolaging.2018.11.007  0.4
2018 Reed X, Bandrés-Ciga S, Blauwendraat C, Cookson MR. The role of monogenic genes in idiopathic Parkinson's disease. Neurobiology of Disease. PMID 30448284 DOI: 10.1016/J.Nbd.2018.11.012  0.444
2018 Russo I, Di Benedetto G, Kaganovich A, Ding J, Mercatelli D, Morari M, Cookson MR, Bubacco L, Greggio E. Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4. Journal of Neuroinflammation. 15: 297. PMID 30368241 DOI: 10.1186/S12974-018-1337-8  0.666
2018 Langston RG, Rudenko IN, Kumaran R, Hauser DN, Kaganovich A, Ponce LB, Mamais A, Ndukwe K, Dillman AA, Al-Saif AM, Beilina A, Cookson MR. Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2. Neurochemical Research. PMID 30291536 DOI: 10.1007/S11064-018-2650-4  0.762
2018 Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nature Neuroscience. 21: 1300-1309. PMID 30258237 DOI: 10.1038/S41593-018-0237-7  0.59
2018 Pihlstrøm L, Blauwendraat C, Cappelletti C, Berge-Seidl V, Langmyhr M, Henriksen SP, van de Berg WDJ, Gibbs JR, Cookson MR, Singleton AB, Nalls MA, Toft M. A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease. Annals of Neurology. PMID 30146727 DOI: 10.1002/Ana.25274  0.535
2018 Parrado-Fernández C, Schneider B, Ankarcrona M, Conti MM, Cookson MR, Kivipelto M, Cedazo-Mínguez Á, Sandebring-Matton A. Reduction of PINK1 or DJ-1 impair mitochondrial motility in neurites and alter ER-mitochondria contacts. Journal of Cellular and Molecular Medicine. PMID 30133157 DOI: 10.1111/Jcmm.13815  0.324
2018 Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, et al. Finding useful biomarkers for Parkinson's disease. Science Translational Medicine. 10. PMID 30111645 DOI: 10.1126/Scitranslmed.Aam6003  0.519
2018 Mamais A, Manzoni C, Nazish I, Arber C, Sonustun B, Wray S, Warner TT, Cookson MR, Lewis PA, Bandopadhyay R. Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology. Brain Research. PMID 30055128 DOI: 10.1016/J.Brainres.2018.07.023  0.611
2018 Blauwendraat C, Reed X, Kia DA, Gan-Or Z, Lesage S, Pihlstrøm L, Guerreiro R, Gibbs JR, Sabir M, Ahmed S, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, ... ... Cookson MR, et al. Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease. Jama Neurology. PMID 30039155 DOI: 10.1001/Jamaneurol.2018.1885  0.708
2018 Pellegrini L, Hauser DN, Li Y, Mamais A, Beilina A, Kumaran R, Wetzel A, Heaton G, Rudenko I, Alkaslasi M, Ivanina N, Melrose HL, Cookson MR, Harvey K. Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice. Human Molecular Genetics. PMID 29917075 DOI: 10.1093/Hmg/Ddy232  0.766
2018 Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H. AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons. Scientific Reports. 8: 8855. PMID 29891871 DOI: 10.1038/S41598-018-26949-6  0.547
2018 Kluss JH, Conti MM, Kaganovich A, Beilina A, Melrose HL, Cookson MR, Mamais A. Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity. Npj Parkinson's Disease. 4: 13. PMID 29707617 DOI: 10.1038/S41531-018-0049-1  0.353
2018 Manzoni C, Mamais A, Dihanich S, Soutar MPM, Plun-Favreau H, Bandopadhyay R, Abeti R, Giunti P, Hardy J, Cookson M, Tooze SA, Lewis PA. mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition. Bioscience Reports. PMID 29563162 DOI: 10.1042/Bsr20171669  0.469
2018 Tomkins JE, Dihanich S, Beilina A, Ferrari R, Ilacqua N, Cookson MR, Lewis PA, Manzoni C. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Proteomics. PMID 29513927 DOI: 10.1002/Pmic.201700444  0.306
2018 Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, ... ... Cookson MR, et al. Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation. Molecular Neurodegeneration. 13: 3. PMID 29357897 DOI: 10.1186/S13024-018-0235-Y  0.706
2018 Price A, Manzoni C, Cookson MR, Lewis PA. The LRRK2 signalling system. Cell and Tissue Research. PMID 29308544 DOI: 10.1007/S00441-017-2759-9  0.452
2017 Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans JM, Chartier-Harlin MC, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, et al. PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2. Frontiers in Molecular Neuroscience. 10: 417. PMID 29311810 DOI: 10.3389/Fnmol.2017.00417  0.747
2017 Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE. The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo. Frontiers in Neuroscience. 11: 702. PMID 29311783 DOI: 10.3389/Fnins.2017.00702  0.509
2017 Dillman AA, Majounie E, Ding J, Gibbs JR, Hernandez D, Arepalli S, Traynor BJ, Singleton AB, Galter D, Cookson MR. Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging. Scientific Reports. 7: 16890. PMID 29203886 DOI: 10.1038/S41598-017-17322-0  0.477
2017 Liu Z, Bryant N, Kumaran R, Beilina A, Abeliovich A, Cookson MR, West AB. LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. Human Molecular Genetics. PMID 29177506 DOI: 10.1093/Hmg/Ddx410  0.418
2017 Hauser DN, Mamais A, Conti MM, Primiani CT, Kumaran R, Dillman AA, Langston RG, Beilina A, Garcia JH, Diaz-Ruiz A, Bernier M, Fiesel FC, Hou X, Springer W, Li Y, ... ... Cookson MR, et al. Hexokinases link DJ-1 to the PINK1/parkin pathway. Molecular Neurodegeneration. 12: 70. PMID 28962651 DOI: 10.1186/S13024-017-0212-X  0.73
2017 Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW, Su B, Cookson MR, Li X, Kang Z. LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection. The Journal of Experimental Medicine. PMID 28821568 DOI: 10.1084/Jem.20170014  0.315
2017 Bandres-Ciga S, Cookson MR. Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28782845 DOI: 10.1002/Mds.27116  0.338
2017 Cookson MR. Gene Linkage and Systems Biology. Advances in Neurobiology. 15: 479-489. PMID 28674994 DOI: 10.1007/978-3-319-57193-5_19  0.417
2017 Cookson MR. Mechanisms of Mutant LRRK2 Neurodegeneration. Advances in Neurobiology. 14: 227-239. PMID 28353287 DOI: 10.1007/978-3-319-49969-7_12  0.459
2017 Rudenko IN, Kaganovich A, Langston RG, Beilina A, Ndukwe K, Kumaran R, Dillman AA, Chia R, Cookson MR. The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2. The Biochemical Journal. PMID 28320779 DOI: 10.1042/Bcj20160909  0.464
2017 Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, ... ... Cookson MR, et al. Novel genetic loci associated with hippocampal volume. Nature Communications. 8: 13624. PMID 28098162 DOI: 10.1038/Ncomms13624  0.526
2017 Soreq L, Rose J, Soreq E, Hardy J, Trabzuni D, Cookson MR, Smith C, Ryten M, Patani R, Ule J. Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging. Cell Reports. 18: 557-570. PMID 28076797 DOI: 10.1016/J.Celrep.2016.12.011  0.46
2016 Roosen DA, Cookson MR. LRRK2 at the interface of autophagosomes, endosomes and lysosomes. Molecular Neurodegeneration. 11: 73. PMID 27927216 DOI: 10.1186/S13024-016-0140-1  0.427
2016 Cookson MR. Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease. Biochemical Society Transactions. 44: 1603-1610. PMID 27913668 DOI: 10.1042/Bst20160228  0.435
2016 Manzoni C, Mamais A, Roosen DA, Dihanich S, Soutar MP, Plun-Favreau H, Bandopadhyay R, Hardy J, Tooze SA, Cookson MR, Lewis PA. mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Scientific Reports. 6: 35106. PMID 27731364 DOI: 10.1038/Srep35106  0.478
2016 Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, ... ... Cookson MR, et al. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience. PMID 27694991 DOI: 10.1038/Nn.4398  0.587
2016 Cookson MR. RNA-binding proteins implicated in neurodegenerative diseases. Wiley Interdisciplinary Reviews. Rna. PMID 27659605 DOI: 10.1002/Wrna.1397  0.362
2016 Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, et al. Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27482083 DOI: 10.1073/Pnas.1610099113  0.424
2016 Cookson MR. Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 113: 8346-8. PMID 27422551 DOI: 10.1073/Pnas.1609311113  0.477
2016 Blauwendraat C, Francescatto M, Gibbs JR, Jansen IE, Simón-Sánchez J, Hernandez DG, Dillman AA, Singleton AB, Cookson MR, Rizzu P, Heutink P. Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe. Genome Medicine. 8: 65. PMID 27287230 DOI: 10.1186/S13073-016-0320-1  0.47
2016 Hauser DN, Primiani CT, Cookson MR. The effects of variants in the PARK2 (parkin), PINK1, and PARK7 (DJ-1) genes along with evidence for their pathogenicity. Current Protein & Peptide Science. PMID 26965687 DOI: 10.2174/1389203717666160311121954  0.742
2016 Langston RG, Rudenko IN, Cookson MR. The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research. The Biochemical Journal. 473: 221-32. PMID 26811536 DOI: 10.1042/Bj20150985  0.452
2015 Hauser DN, Primiani CT, Langston RG, Kumaran R, Cookson MR. The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice. Eneuro. 2. PMID 26464968 DOI: 10.1523/ENEURO.0075-14.2015  0.693
2015 Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C, Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, ... Cookson MR, et al. Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. Journal of Neurochemistry. PMID 26375402 DOI: 10.1111/Jnc.13369  0.628
2015 Beilina A, Cookson MR. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Journal of Neurochemistry. PMID 26223426 DOI: 10.1111/Jnc.13266  0.459
2015 Kumaran R, Cookson MR. Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease. Human Molecular Genetics. 24: R32-44. PMID 26101198 DOI: 10.1093/Hmg/Ddv236  0.48
2015 Cookson MR. LRRK2 Pathways Leading to Neurodegeneration. Current Neurology and Neuroscience Reports. 15: 42. PMID 26008812 DOI: 10.1007/S11910-015-0564-Y  0.477
2015 Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala BS, Armstrong NJ, Bernard M, Bohlken MM, Boks MP, ... ... Cookson MR, et al. Common genetic variants influence human subcortical brain structures. Nature. 520: 224-9. PMID 25607358 DOI: 10.1038/Nature14101  0.569
2015 Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, ... ... Cookson MR, et al. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. The American Journal of Psychiatry. 172: 82-93. PMID 25158072 DOI: 10.1176/Appi.Ajp.2014.13101306  0.329
2014 Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nature Communications. 5: 5827. PMID 25500533 DOI: 10.1038/Ncomms6827  0.4
2014 Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, De T, Coin L, de Silva R, Cookson MR, Singleton AB, Hardy J, Ryten M, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nature Neuroscience. 17: 1418-28. PMID 25174004 DOI: 10.1038/Nn.3801  0.592
2014 Cookson MR. Lardy brains make Parkinson's disease mice worse. Journal of Neurochemistry. 131: 697-8. PMID 25142063 DOI: 10.1111/Jnc.12843  0.43
2014 Rudenko IN, Cookson MR. Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 738-50. PMID 24957201 DOI: 10.1007/S13311-014-0284-Z  0.465
2014 Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, et al. Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. Journal of Neurochemistry. PMID 24947832 DOI: 10.1111/Jnc.12798  0.386
2014 Mamais A, Chia R, Beilina A, Hauser DN, Hall C, Lewis PA, Cookson MR, Bandopadhyay R. Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. The Journal of Biological Chemistry. 289: 21386-400. PMID 24942733 DOI: 10.1074/Jbc.M113.528463  0.73
2014 Prahlad J, Hauser DN, Milkovic NM, Cookson MR, Wilson MA. Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers. Journal of Neurochemistry. 130: 839-53. PMID 24832775 DOI: 10.1111/Jnc.12763  0.71
2014 Rojas-Charry L, Cookson MR, Niño A, Arboleda H, Arboleda G. Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. Neurotoxicology. 44: 140-8. PMID 24792327 DOI: 10.1016/J.Neuro.2014.04.007  0.322
2014 Hauser DN, Dillman AA, Ding J, Li Y, Cookson MR. Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain. Plos One. 9: e94646. PMID 24722488 DOI: 10.1371/Journal.Pone.0094646  0.724
2014 Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, ... ... Cookson MR, et al. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience. 17: 664-6. PMID 24686783 DOI: 10.1038/Nn.3688  0.577
2014 Mamais A, Cookson MR. LRRK2: dropping (kinase) inhibitions and seeking an (immune) response. Journal of Neurochemistry. 129: 895-7. PMID 24661004 DOI: 10.1111/Jnc.12691  0.387
2014 Liao J, Wu CX, Burlak C, Zhang S, Sahm H, Wang M, Zhang ZY, Vogel KW, Federici M, Riddle SM, Nichols RJ, Liu D, Cookson MR, Stone TA, Hoang QQ. Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain. Proceedings of the National Academy of Sciences of the United States of America. 111: 4055-60. PMID 24591621 DOI: 10.1073/Pnas.1323285111  0.417
2014 Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA, Olszewski M, ... ... Cookson MR, et al. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 111: 2626-31. PMID 24510904 DOI: 10.1073/Pnas.1318306111  0.774
2014 Skibinski G, Nakamura K, Cookson MR, Finkbeiner S. Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 418-33. PMID 24403142 DOI: 10.1523/Jneurosci.2712-13.2014  0.446
2014 Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ramírez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, et al. A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation. The Journal of Biological Chemistry. 289: 895-908. PMID 24275654 DOI: 10.1074/Jbc.M113.507913  0.39
2014 Nalls MA, Saad M, Noyce AJ, Keller MF, Schrag A, Bestwick JP, Traynor BJ, Gibbs JR, Hernandez DG, Cookson MR, Morris HR, Williams N, Gasser T, Heutink P, Wood N, et al. Genetic comorbidities in Parkinson's disease. Human Molecular Genetics. 23: 831-41. PMID 24057672 DOI: 10.1093/Hmg/Ddt465  0.628
2014 McCoy MK, Kaganovich A, Rudenko IN, Ding J, Cookson MR. Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Human Molecular Genetics. 23: 145-56. PMID 23962723 DOI: 10.1093/Hmg/Ddt407  0.339
2013 Lobbestael E, Zhao J, Rudenko IN, Beylina A, Gao F, Wetter J, Beullens M, Bollen M, Cookson MR, Baekelandt V, Nichols RJ, Taymans JM. Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. The Biochemical Journal. 456: 119-28. PMID 23937259 DOI: 10.1042/Bj20121772  0.442
2013 Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E. Lysosomal impairment in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 725-32. PMID 23580333 DOI: 10.1002/Mds.25462  0.632
2013 Ramasamy A, Trabzuni D, Gibbs JR, Dillman A, Hernandez DG, Arepalli S, Walker R, Smith C, Ilori GP, Shabalin AA, Li Y, Singleton AB, Cookson MR, Hardy J, et al. Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies. Nucleic Acids Research. 41: e88. PMID 23435227 DOI: 10.1093/Nar/Gkt069  0.528
2013 Majounie E, Cross W, Newsway V, Dillman A, Vandrovcova J, Morris CM, Nalls MA, Ferrucci L, Owen MJ, O'Donovan MC, Cookson MR, Singleton AB, de Silva R, Morris HR. Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging. 34: 1922.e7-1922.e12. PMID 23428180 DOI: 10.1016/J.Neurobiolaging.2013.01.017  0.572
2013 Dillman AA, Hauser DN, Gibbs JR, Nalls MA, McCoy MK, Rudenko IN, Galter D, Cookson MR. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nature Neuroscience. 16: 499-506. PMID 23416452 DOI: 10.1038/Nn.3332  0.679
2013 Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Ramirez-Restrepo M, ... ... Cookson MR, et al. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Annals of Human Genetics. 77: 85-105. PMID 23360175 DOI: 10.1111/Ahg.12000  0.692
2013 Salehi B, Preuss N, van der Veen JW, Shen J, Neumeister A, Drevets WC, Hodgkinson C, Goldman D, Wendland JR, Singleton A, Gibbs JR, Cookson MR, Hasler G. Age-modulated association between prefrontal NAA and the BDNF gene. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1185-93. PMID 23253771 DOI: 10.1017/S1461145712001204  0.447
2013 Kumar A, Gibbs JR, Beilina A, Dillman A, Kumaran R, Trabzuni D, Ryten M, Walker R, Smith C, Traynor BJ, Hardy J, Singleton AB, Cookson MR. Age-associated changes in gene expression in human brain and isolated neurons. Neurobiology of Aging. 34: 1199-209. PMID 23177596 DOI: 10.1016/J.Neurobiolaging.2012.10.021  0.567
2013 Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, ... ... Cookson MR, et al. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry. 18: 788-98. PMID 22889921 DOI: 10.1038/Mp.2012.85  0.542
2013 Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, ... ... Cookson MR, et al. Erratum: Genome-wide association study of obsessive-compulsive disorder Molecular Psychiatry. 18: 843-843. DOI: 10.1038/Mp.2013.15  0.497
2012 Kuhn A, Kumar A, Beilina A, Dillman A, Cookson MR, Singleton AB. Cell population-specific expression analysis of human cerebellum. Bmc Genomics. 13: 610. PMID 23145530 DOI: 10.1186/1471-2164-13-610  0.466
2012 Cookson MR. Cellular effects of LRRK2 mutations. Biochemical Society Transactions. 40: 1070-3. PMID 22988867 DOI: 10.1042/Bst20120165  0.48
2012 Cookson MR. Evolution of neurodegeneration. Current Biology : Cb. 22: R753-61. PMID 22975006 DOI: 10.1016/J.Cub.2012.07.008  0.391
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Cookson MR, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.472
2012 Civiero L, Vancraenenbroeck R, Belluzzi E, Beilina A, Lobbestael E, Reyniers L, Gao F, Micetic I, De Maeyer M, Bubacco L, Baekelandt V, Cookson MR, Greggio E, Taymans JM. Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. Plos One. 7: e43472. PMID 22952686 DOI: 10.1371/Journal.Pone.0043472  0.625
2012 Cookson MR. Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways. Cold Spring Harbor Perspectives in Medicine. 2: a009415. PMID 22951446 DOI: 10.1101/Cshperspect.A009415  0.374
2012 Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, Smith C, Luk C, Gibbs JR, Dillman A, Hernandez DG, Arepalli S, Singleton AB, Cookson MR, Pittman AM, de Silva R, et al. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Human Molecular Genetics. 21: 4094-103. PMID 22723018 DOI: 10.1093/Hmg/Dds238  0.685
2012 Rudenko IN, Kaganovich A, Hauser DN, Beylina A, Chia R, Ding J, Maric D, Jaffe H, Cookson MR. The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. The Biochemical Journal. 446: 99-111. PMID 22612223 DOI: 10.1042/Bj20120637  0.763
2012 Hernandez DG, Nalls MA, Moore M, Chong S, Dillman A, Trabzuni D, Gibbs JR, Ryten M, Arepalli S, Weale ME, Zonderman AB, Troncoso J, O'Brien R, Walker R, Smith C, ... ... Cookson MR, et al. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiology of Disease. 47: 20-8. PMID 22433082 DOI: 10.1016/J.Nbd.2012.03.020  0.574
2012 Rudenko IN, Chia R, Cookson MR. Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease? Bmc Medicine. 10: 20. PMID 22361010 DOI: 10.1186/1741-7015-10-20  0.449
2012 Matsuki T, Zaka M, Guerreiro R, van der Brug MP, Cooper JA, Cookson MR, Hardy JA, Howell BW. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. Plos One. 7: e31152. PMID 22355340 DOI: 10.1371/Journal.Pone.0031152  0.661
2012 Bandmann O, Cookson MR. Parkinson disease, cancer, and LRRK2: causation or association? Neurology. 78: 772-3. PMID 22323745 DOI: 10.1212/Wnl.0B013E318249F744  0.381
2012 Lewis PA, Cookson MR. Gene expression in the Parkinson's disease brain. Brain Research Bulletin. 88: 302-12. PMID 22173063 DOI: 10.1016/J.Brainresbull.2011.11.016  0.392
2012 McCoy MK, Cookson MR. Mitochondrial quality control and dynamics in Parkinson's disease. Antioxidants & Redox Signaling. 16: 869-82. PMID 21568830 DOI: 10.1089/Ars.2011.4019  0.369
2012 Civiero L, Lobbestael E, Gao F, Beilina A, Reyniers L, Vancraenenbroeck R, Belluzzi E, Micetic I, Maeyer MD, Bubacco L, Baekelandt V, Cookson M, Taymans J, Greggio E. Electron microscopy analysis of purified LRRK1 and LRRK2 demonstrates formation of dimers F1000research. 3. DOI: 10.7490/F1000Research.1090051.1  0.514
2012 Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman J, Hardy J, Marti-Masso J, Healy D, ... ... Cookson MR, et al. Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue Plos One. 7. DOI: 10.1371/annotation/c12e4f9e-5aae-424b-a69f-fddf16976dc5  0.392
2012 Scharf J, Yu D, Mathews C, Neale B, Stewart E, Fagerness J, Evans P, Gamazon E, Service S, Osiecki L, Illmann C, Cath D, King R, Dion Y, Sandor P, ... ... Cookson M, et al. Genome-Wide Association Study of Gilles de la Tourette Syndrome (IN10-1.002) Neurology. 78: IN10-1.002-IN10-1.00. DOI: 10.1212/Wnl.78.1_Meetingabstracts.In10-1.002  0.335
2011 Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, et al. A soluble α-synuclein construct forms a dynamic tetramer. Proceedings of the National Academy of Sciences of the United States of America. 108: 17797-802. PMID 22006323 DOI: 10.1073/Pnas.1113260108  0.305
2011 Taymans JM, Vancraenenbroeck R, Ollikainen P, Beilina A, Lobbestael E, De Maeyer M, Baekelandt V, Cookson MR. LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. Plos One. 6: e23207. PMID 21858031 DOI: 10.1371/Journal.Pone.0023207  0.358
2011 Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, ... ... Cookson MR, et al. Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue. Plos One. 6: e22489. PMID 21799870 DOI: 10.1371/Journal.Pone.0022489  0.537
2011 Choi JH, Stubblefield B, Cookson MR, Goldin E, Velayati A, Tayebi N, Sidransky E. Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations. Molecular Genetics and Metabolism. 104: 185-8. PMID 21742527 DOI: 10.1016/J.Ymgme.2011.06.008  0.424
2011 Cookson MR. A feedforward loop links Gaucher and Parkinson's diseases? Cell. 146: 9-11. PMID 21729776 DOI: 10.1016/J.Cell.2011.06.031  0.435
2011 Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, ... ... Cookson MR, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 43: 699-705. PMID 21685912 DOI: 10.1038/Ng.859  0.676
2011 Kumar A, Cookson MR. Role of LRRK2 kinase dysfunction in Parkinson disease. Expert Reviews in Molecular Medicine. 13: e20. PMID 21676337 DOI: 10.1017/S146239941100192X  0.467
2011 Hauser DN, Cookson MR. Astrocytes in Parkinson's disease and DJ-1. Journal of Neurochemistry. 117: 357-8. PMID 21413989 DOI: 10.1111/J.1471-4159.2011.07217.X  0.743
2011 McCoy MK, Cookson MR. DJ-1 regulation of mitochondrial function and autophagy through oxidative stress. Autophagy. 7: 531-2. PMID 21317550 DOI: 10.4161/Auto.7.5.14684  0.334
2011 Hernandez DG, Nalls MA, Gibbs JR, Arepalli S, van der Brug M, Chong S, Moore M, Longo DL, Cookson MR, Traynor BJ, Singleton AB. Distinct DNA methylation changes highly correlated with chronological age in the human brain. Human Molecular Genetics. 20: 1164-72. PMID 21216877 DOI: 10.1093/Hmg/Ddq561  0.437
2011 Daniëls V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, Taymans JM. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. Journal of Neurochemistry. 116: 304-15. PMID 21073465 DOI: 10.1111/J.1471-4159.2010.07105.X  0.378
2011 Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Human Molecular Genetics. 20: 40-50. PMID 20940149 DOI: 10.1093/Hmg/Ddq430  0.344
2011 Lai SL, Abramzon Y, Schymick JC, Stephan DA, Dunckley T, Dillman A, Cookson M, Calvo A, Battistini S, Giannini F, Caponnetto C, Mancardi GL, Spataro R, Monsurro MR, Tedeschi G, et al. FUS mutations in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 32: 550.e1-4. PMID 20138404 DOI: 10.1016/J.Neurobiolaging.2009.12.020  0.342
2011 Cookson MR. Conference Scene: Parkinson’s disease in the UK: a report from the Parkinson’s UK Research Conference Neurodegenerative Disease Management. 1: 25-27. DOI: 10.2217/Nmt.10.5  0.325
2010 Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW. Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell. 143: 826-36. PMID 21111240 DOI: 10.1016/J.Cell.2010.10.029  0.412
2010 Cookson MR. The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nature Reviews. Neuroscience. 11: 791-7. PMID 21088684 DOI: 10.1038/Nrn2935  0.484
2010 Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, et al. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. American Journal of Human Genetics. 87: 890-7. PMID 21087763 DOI: 10.1016/J.Ajhg.2010.11.002  0.482
2010 Rudenko IN, Cookson MR. 14-3-3 proteins are promising LRRK2 interactors. The Biochemical Journal. 430: e5-6. PMID 20795948 DOI: 10.1042/Bj20101200  0.416
2010 Cookson MR. Unravelling the role of defective genes. Progress in Brain Research. 183: 43-57. PMID 20696314 DOI: 10.1016/S0079-6123(10)83003-1  0.484
2010 Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, Arepalli S, Dillman A, Rafferty IP, Troncoso J, Johnson R, Zielke HR, Ferrucci L, Longo DL, Cookson MR, et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. Plos Genetics. 6: e1000952. PMID 20485568 DOI: 10.1371/Journal.Pgen.1000952  0.461
2010 Cookson MR, Bandmann O. Parkinson's disease: insights from pathways. Human Molecular Genetics. 19: R21-7. PMID 20421364 DOI: 10.1093/Hmg/Ddq167  0.497
2010 Bisaglia M, Greggio E, Maric D, Miller DW, Cookson MR, Bubacco L. Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells. Bmc Neuroscience. 11: 41. PMID 20334701 DOI: 10.1186/1471-2202-11-41  0.619
2010 Cookson MR. DJ-1, PINK1, and their effects on mitochondrial pathways. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S44-8. PMID 20187230 DOI: 10.1002/Mds.22713  0.473
2010 Taymans JM, Cookson MR. Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 32: 227-35. PMID 20127702 DOI: 10.1002/Bies.200900163  0.467
2010 Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. Plos Biology. 8: e1000298. PMID 20126261 DOI: 10.1371/Journal.Pbio.1000298  0.34
2010 Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. Plos One. 5: e8730. PMID 20090955 DOI: 10.1371/Journal.Pone.0008730  0.392
2010 Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. Journal of Neurochemistry. 112: 1593-604. PMID 20067578 DOI: 10.1111/J.1471-4159.2010.06568.X  0.448
2009 Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, ... ... Cookson MR, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics. 41: 1308-12. PMID 19915575 DOI: 10.1038/Ng.487  0.681
2009 Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA, Deng J. The R1441C mutation alters the folding properties of the ROC domain of LRRK2. Biochimica Et Biophysica Acta. 1792: 1194-7. PMID 19781641 DOI: 10.1016/J.Bbadis.2009.09.010  0.359
2009 O'Farrell CA, Martin KL, Hutton M, Delatycki MB, Cookson MR, Lockhart PJ. Mutant torsinA interacts with tyrosine hydroxylase in cultured cells. Neuroscience. 164: 1127-37. PMID 19761814 DOI: 10.1016/J.Neuroscience.2009.09.017  0.56
2009 Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR. The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochemical and Biophysical Research Communications. 389: 449-54. PMID 19733152 DOI: 10.1016/J.Bbrc.2009.08.163  0.389
2009 Thomas KJ, Cookson MR. The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. The International Journal of Biochemistry & Cell Biology. 41: 2025-35. PMID 19703660 DOI: 10.1016/J.Biocel.2009.02.018  0.424
2009 Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Mínguez A. Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling. The Febs Journal. 276: 5041-52. PMID 19663908 DOI: 10.1111/J.1742-4658.2009.07201.X  0.316
2009 Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. The American Journal of Pathology. 175: 736-47. PMID 19628769 DOI: 10.2353/Ajpath.2009.080928  0.55
2009 Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, ... Cookson M, et al. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9210-8. PMID 19625511 DOI: 10.1523/Jneurosci.2281-09.2009  0.406
2009 Greggio E, Cookson MR. Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. Asn Neuro. 1. PMID 19570025 DOI: 10.1042/An20090007  0.432
2009 Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-Mínguez A, Cookson MR. Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. Plos One. 4: e5701. PMID 19492085 DOI: 10.1371/Journal.Pone.0005701  0.316
2009 Sleiman PM, Healy DG, Muqit MM, Yang YX, Van Der Brug M, Holton JL, Revesz T, Quinn NP, Bhatia K, Diss JK, Lees AJ, Cookson MR, Latchman DS, Wood NW. Characterisation of a novel NR4A2 mutation in Parkinson's disease brain. Neuroscience Letters. 457: 75-9. PMID 19429166 DOI: 10.1016/J.Neulet.2009.03.021  0.42
2009 Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT. Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 4635-40. PMID 19261853 DOI: 10.1073/Pnas.0806474106  0.339
2009 Cookson MR. alpha-Synuclein and neuronal cell death. Molecular Neurodegeneration. 4: 9. PMID 19193223 DOI: 10.1186/1750-1326-4-9  0.412
2009 Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry. 48: 2045-52. PMID 19152501 DOI: 10.1021/Bi8019178  0.324
2009 Blackinton J, Kumaran R, van der Brug MP, Ahmad R, Olson L, Galter D, Lees A, Bandopadhyay R, Cookson MR. Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease. Neuroscience Letters. 452: 8-11. PMID 19146923 DOI: 10.1016/J.Neulet.2008.12.053  0.438
2009 Blackinton J, Lakshminarasimhan M, Thomas KJ, Ahmad R, Greggio E, Raza AS, Cookson MR, Wilson MA. Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. The Journal of Biological Chemistry. 284: 6476-85. PMID 19124468 DOI: 10.1074/Jbc.M806599200  0.341
2009 Dehvari N, Sandebring A, Flores-Morales A, Mateos L, Chuan YC, Goldberg MS, Cookson MR, Cowburn RF, Cedazo-Mínguez A. Parkin-mediated ubiquitination regulates phospholipase C-gamma1. Journal of Cellular and Molecular Medicine. 13: 3061-8. PMID 18671761 DOI: 10.1111/J.1582-4934.2008.00443.X  0.468
2009 Bisaglia M, Greggio E, Tosatto L, Munari F, Maric D, Tessari I, Polverino de Laureto P, Miller D, Mammi S, Cookson M, Bubacco L. P3.002 Modiflcation by dopamine adducts links a-synuclein to oxidative stress in Parkinson's disease Parkinsonism & Related Disorders. 15: S148. DOI: 10.1016/S1353-8020(09)70566-8  0.58
2008 Bras J, Singleton A, Cookson MR, Hardy J. Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease. The Febs Journal. 275: 5767-73. PMID 19021754 DOI: 10.1111/J.1742-4658.2008.06709.X  0.616
2008 Cookson MR, Hardy J, Lewis PA. Genetic neuropathology of Parkinson's disease. International Journal of Clinical and Experimental Pathology. 1: 217-31. PMID 18784814  0.488
2008 van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, Beilina A, Gibbs JR, Ding J, Myers AJ, Zhan M, ... ... Cookson MR, et al. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 10244-9. PMID 18626009 DOI: 10.1073/Pnas.0708518105  0.412
2008 Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. The Journal of Biological Chemistry. 283: 16906-14. PMID 18397888 DOI: 10.1074/Jbc.M708718200  0.4
2008 Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, Moore DJ, Dawson TM, Dawson VL, Chiosis G, Cookson MR, et al. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3384-91. PMID 18367605 DOI: 10.1523/Jneurosci.0185-08.2008  0.452
2008 Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, et al. DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA. The Lancet. Neurology. 7: 207-15. PMID 18243799 DOI: 10.1016/S1474-4422(08)70022-X  0.729
2008 Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proceedings of the National Academy of Sciences of the United States of America. 105: 1499-504. PMID 18230735 DOI: 10.1073/Pnas.0709098105  0.409
2008 Haque ME, Thomas KJ, D'Souza C, Callaghan S, Kitada T, Slack RS, Fraser P, Cookson MR, Tandon A, Park DS. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America. 105: 1716-21. PMID 18218782 DOI: 10.1073/Pnas.0705363105  0.409
2008 Cookson MR, van der Brug M. Cell systems and the toxic mechanism(s) of alpha-synuclein. Experimental Neurology. 209: 5-11. PMID 17603039 DOI: 10.1016/J.Expneurol.2007.05.022  0.397
2008 Thomas KJ, Sandebring A, Beilina A, van der Brug M, Cleland MM, Zambrano I, Miller DW, Unger C, Cowburn R, Youle R, Behbahani H, Cedazo-Mínguez A, Cookson MR. S9.4 Altered mitochondrial dynamics caused by loss of PTEN-induced kinase 1 function, associated with recessive parkinsonism, are reversed by downregulation of Dynamin-related protein 1 Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1777: S55. DOI: 10.1016/J.Bbabio.2008.05.219  0.387
2007 Cookson MR, Dauer W, Dawson T, Fon EA, Guo M, Shen J. The roles of kinases in familial Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11865-8. PMID 17978026 DOI: 10.1523/Jneurosci.3695-07.2007  0.486
2007 Blackinton JG, Anvret A, Beilina A, Olson L, Cookson MR, Galter D. Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease. Brain Research. 1184: 10-6. PMID 17950257 DOI: 10.1016/J.Brainres.2007.09.056  0.384
2007 Hoe HS, Cooper MJ, Burns MP, Lewis PA, van der Brug M, Chakraborty G, Cartagena CM, Pak DT, Cookson MR, Rebeck GW. The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10895-905. PMID 17913923 DOI: 10.1523/Jneurosci.3135-07.2007  0.315
2007 van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, et al. Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. Plos Genetics. 3: e108. PMID 17590087 DOI: 10.1371/Journal.Pgen.0030108  0.591
2007 Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR. The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochemical and Biophysical Research Communications. 357: 668-71. PMID 17442267 DOI: 10.1016/J.Bbrc.2007.04.006  0.455
2007 Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR. Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. Journal of Neurochemistry. 102: 93-102. PMID 17394548 DOI: 10.1111/J.1471-4159.2007.04523.X  0.435
2006 Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, et al. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Bmc Neurology. 6: 44. PMID 17166276 DOI: 10.1186/1471-2377-6-44  0.647
2006 Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A. Genetics of Parkinson's disease and parkinsonism. Annals of Neurology. 60: 389-98. PMID 17068789 DOI: 10.1002/Ana.21022  0.722
2006 Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, ... ... Cookson MR, et al. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiology of Disease. 23: 329-41. PMID 16750377 DOI: 10.1016/J.Nbd.2006.04.001  0.593
2006 Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, ... Cookson MR, et al. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. Neurobiology of Disease. 22: 404-20. PMID 16439141 DOI: 10.1016/J.Nbd.2005.12.003  0.41
2005 Cookson MR, Clarimon J. Dystonia and the nuclear envelope. Neuron. 48: 875-7. PMID 16364891 DOI: 10.1016/J.Neuron.2005.12.006  0.355
2005 Cookson MR, Xiromerisiou G, Singleton A. How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease. Current Opinion in Neurology. 18: 706-11. PMID 16280683 DOI: 10.1097/01.Wco.0000186841.43505.E6  0.615
2005 Cookson MR. Neurons inflict self-harm. Nature Medicine. 11: 1159-61. PMID 16270070 DOI: 10.1038/Nm1105-1159  0.328
2005 Bandopadhyay R, Miller DW, Kingsbury AE, Jowett TP, Kaleem MM, Pittman AM, de Silva R, Cookson MR, Lees AJ. Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein. Neuroscience Letters. 383: 225-30. PMID 15955416 DOI: 10.1016/J.Neulet.2005.04.024  0.324
2005 Cookson MR. The biochemistry of Parkinson's disease. Annual Review of Biochemistry. 74: 29-52. PMID 15952880 DOI: 10.1146/Annurev.Biochem.74.082803.133400  0.475
2005 Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proceedings of the National Academy of Sciences of the United States of America. 102: 5703-8. PMID 15824318 DOI: 10.1073/Pnas.0500617102  0.409
2005 Blackinton J, Ahmad R, Miller DW, van der Brug MP, Canet-Avilés RM, Hague SM, Kaleem M, Cookson MR. Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization. Brain Research. Molecular Brain Research. 134: 76-83. PMID 15790532 DOI: 10.1016/J.Molbrainres.2004.09.004  0.422
2005 Greggio E, Bergantino E, Carter D, Ahmad R, Costin GE, Hearing VJ, Clarimon J, Singleton A, Eerola J, Hellström O, Tienari PJ, Miller DW, Beilina A, Bubacco L, Cookson MR. Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease. Journal of Neurochemistry. 93: 246-56. PMID 15773923 DOI: 10.1111/J.1471-4159.2005.03019.X  0.707
2005 Miller DW, Crawley A, Gwinn-Hardy K, Lopez G, Nussbaum R, Cookson MR, Singleton AB, Hardy J, Dogu O. Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion. Neuroscience Letters. 374: 189-91. PMID 15663960 DOI: 10.1016/J.Neulet.2004.10.053  0.564
2005 Leemput JVd, Chandran J, Knight M, Holtzclaw L, Scholz S, Cookson MR, Houlden H, Gwinn K, Fung P, Lin X, Hernandez DG, Simon-Sanchez J, Wood N, Rafferty I, Hardy J, et al. Deletion at ITPR1 underlies ataxia in mice and humans (SCA15) Plos Genetics. DOI: 10.1371/Journal.Pgen.0030108.Eor  0.516
2004 Miller DW, Cookson MR, Dickson DW. Glial cell inclusions and the pathogenesis of neurodegenerative diseases. Neuron Glia Biology. 1: 13-21. PMID 16614753 DOI: 10.1017/S1740925X04000043  0.356
2004 Cookson MR. Molecules that cause or prevent Parkinson's disease. Plos Biology. 2: e401. PMID 15547643 DOI: 10.1371/Journal.Pbio.0020401  0.379
2004 Cookson MR. Roles of the proteasome in neurodegenerative disease: refining the hypothesis. Annals of Neurology. 56: 315-6. PMID 15349856 DOI: 10.1002/Ana.20258  0.352
2004 O'Farrell C, Lockhart PJ, Lincoln S, De Lucia M, Singleton AB, Dickson DW, Cookson MR. Biochemical characterization of torsinB. Brain Research. Molecular Brain Research. 127: 1-9. PMID 15306116 DOI: 10.1016/J.Molbrainres.2004.05.005  0.499
2004 Shen J, Cookson MR. Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron. 43: 301-4. PMID 15294138 DOI: 10.1016/J.Neuron.2004.07.012  0.424
2004 Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proceedings of the National Academy of Sciences of the United States of America. 101: 9103-8. PMID 15181200 DOI: 10.1073/Pnas.0402959101  0.337
2004 El-Agnaf OM, Paleologou KE, Greer B, Abogrein AM, King JE, Salem SA, Fullwood NJ, Benson FE, Hewitt R, Ford KJ, Martin FL, Harriott P, Cookson MR, Allsop D. A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1315-7. PMID 15180968 DOI: 10.1096/Fj.03-1346Fje  0.369
2004 Miller DW, Hague SM, Clarimon J, Baptista M, Gwinn-Hardy K, Cookson MR, Singleton AB. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology. 62: 1835-8. PMID 15159488 DOI: 10.1212/01.WNL.0000127517.33208.F4  0.463
2004 Bandyopadhyay S, Cookson MR. Evolutionary and functional relationships within the DJ1 superfamily. Bmc Evolutionary Biology. 4: 6. PMID 15070401 DOI: 10.1186/1471-2148-4-6  0.362
2004 Baptista MJ, Cookson MR, Miller DW. Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10: 63-72. PMID 14987449 DOI: 10.1177/1073858403260392  0.419
2004 Bandopadhyay R, Kingsbury AE, Cookson MR, Reid AR, Evans IM, Hope AD, Pittman AM, Lashley T, Canet-Aviles R, Miller DW, McLendon C, Strand C, Leonard AJ, Abou-Sleiman PM, Healy DG, et al. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain : a Journal of Neurology. 127: 420-30. PMID 14662519 DOI: 10.1093/Brain/Awh054  0.552
2003 Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, ... Cookson MR, et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science (New York, N.Y.). 302: 841. PMID 14593171 DOI: 10.1126/Science.1090278  0.717
2003 Cookson MR, Lockhart PJ, McLendon C, O'Farrell C, Schlossmacher M, Farrer MJ. RING finger 1 mutations in Parkin produce altered localization of the protein. Human Molecular Genetics. 12: 2957-65. PMID 14519684 DOI: 10.1093/Hmg/Ddg328  0.568
2003 El-Agnaf OM, Salem SA, Paleologou KE, Cooper LJ, Fullwood NJ, Gibson MJ, Curran MD, Court JA, Mann DM, Ikeda S, Cookson MR, Hardy J, Allsop D. Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1945-7. PMID 14519670 DOI: 10.1096/Fj.03-0098Fje  0.487
2003 Cookson MR. Crystallizing ideas about Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 9111-3. PMID 12886009 DOI: 10.1073/Pnas.1633722100  0.466
2003 Miller DW, Ahmad R, Hague S, Baptista MJ, Canet-Aviles R, McLendon C, Carter DM, Zhu PP, Stadler J, Chandran J, Klinefelter GR, Blackstone C, Cookson MR. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. The Journal of Biological Chemistry. 278: 36588-95. PMID 12851414 DOI: 10.1074/Jbc.M304272200  0.379
2003 Hardy J, Cookson MR, Singleton A. Genes and parkinsonism. The Lancet. Neurology. 2: 221-8. PMID 12849210 DOI: 10.1016/S1474-4422(03)00350-8  0.638
2003 Cookson MR. Neurodegeneration: how does parkin prevent Parkinson's disease? Current Biology : Cb. 13: R522-4. PMID 12842030 DOI: 10.1016/S0960-9822(03)00446-9  0.445
2003 Marx FP, Holzmann C, Strauss KM, Li L, Eberhardt O, Gerhardt E, Cookson MR, Hernandez D, Farrer MJ, Kachergus J, Engelender S, Ross CA, Berger K, Schöls L, Schulz JB, et al. Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease. Human Molecular Genetics. 12: 1223-31. PMID 12761037 DOI: 10.1093/Hmg/Ddg134  0.619
2003 Baptista MJ, O'Farrell C, Hardy J, Cookson MR. Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA. Neuroscience Letters. 343: 5-8. PMID 12749984 DOI: 10.1016/S0304-3940(03)00302-1  0.511
2003 Baptista MJ, O'Farrell C, Daya S, Ahmad R, Miller DW, Hardy J, Farrer MJ, Cookson MR. Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines. Journal of Neurochemistry. 85: 957-68. PMID 12716427 DOI: 10.1046/J.1471-4159.2003.01742.X  0.636
2003 Cookson MR. Parkin's substrates and the pathways leading to neuronal damage. Neuromolecular Medicine. 3: 1-13. PMID 12665672 DOI: 10.1385/Nmm:3:1:1  0.449
2003 Cookson MR. Pathways to Parkinsonism. Neuron. 37: 7-10. PMID 12526767 DOI: 10.1016/S0896-6273(02)01166-2  0.459
2002 Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 36: 1007-19. PMID 12495618 DOI: 10.1016/S0896-6273(02)01125-X  0.697
2002 Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, Ince PG, Shaw PJ. Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis. Journal of Neurochemistry. 82: 1118-28. PMID 12358759 DOI: 10.1046/J.1471-4159.2002.01045.X  0.347
2002 O'Farrell C, Hernandez DG, Evey C, Singleton AB, Cookson MR. Normal localization of deltaF323-Y328 mutant torsinA in transfected human cells. Neuroscience Letters. 327: 75-8. PMID 12098639 DOI: 10.1016/S0304-3940(02)00400-7  0.435
2002 O'Farrell C, Pickford F, Vink L, McGowan E, Cookson MR. Sequence conservation between mouse and human synphilin-1. Neuroscience Letters. 322: 9-12. PMID 11958831 DOI: 10.1016/S0304-3940(02)00068-X  0.51
2002 Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT. An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage The Journal of Neuroscience. 22: 7006-7015. DOI: 10.1523/Jneurosci.22-16-07006.2002  0.361
2001 O'Farrell C, Murphy DD, Petrucelli L, Singleton AB, Hussey J, Farrer M, Hardy J, Dickson DW, Cookson MR. Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells. Brain Research. Molecular Brain Research. 97: 94-102. PMID 11744167 DOI: 10.1016/S0169-328X(01)00292-3  0.732
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