Hitoshi Hashimoto, Ph.D. - Publications

Affiliations: 
Laboratory of Molecular Neuropharmacology  Osaka University, Toyonaka-shi, Ōsaka-fu, Japan 
Website:
http://molpharm.umin.jp/index-e.html

164 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Takeuchi S, Kawanai T, Yamauchi R, Chen L, Miyaoka T, Yamada M, Asano S, Hayata-Takano A, Nakazawa T, Yano K, Horiguchi N, Nakagawa S, Takuma K, Waschek JA, Hashimoto H, et al. Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism. Frontiers in Neuroscience. 14: 521. PMID 32581681 DOI: 10.3389/fnins.2020.00521  0.52
2020 Tanuma M, Kasai A, Bando K, Kotoku N, Harada K, Minoshima M, Higashino K, Kimishima A, Arai M, Ago Y, Seiriki K, Kikuchi K, Kawata S, Fujita K, Hashimoto H. Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain. Jci Insight. PMID 32125287 DOI: 10.1172/jci.insight.133348  0.48
2020 Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, ... ... Hashimoto H, et al. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nature Communications. 11: 859. PMID 32103003 DOI: 10.1038/s41467-020-14697-z  0.76
2020 Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y. (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. Pharmacology, Biochemistry, and Behavior. 172876. PMID 32088360 DOI: 10.1016/j.pbb.2020.172876  0.48
2020 Nguyen TT, Kambe Y, Kurihara T, Nakamachi T, Shintani N, Hashimoto H, Miyata A. Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice. Molecular Neurobiology. PMID 31927724 DOI: 10.1007/s12035-019-01864-7  0.76
2019 Fulop DB, Humli V, Szepesy J, Ott V, Reglodi D, Gaszner B, Nemeth A, Szirmai A, Tamas L, Hashimoto H, Zelles T, Tamas A. Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. Scientific Reports. 9: 14598. PMID 31601840 DOI: 10.1038/s41598-019-50775-z  0.32
2019 Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Iguchi T, Sato M, ... ... Hashimoto H, et al. Autism-associated protein kinase D2 regulates embryonic cortical neuron development. Biochemical and Biophysical Research Communications. PMID 31540692 DOI: 10.1016/j.bbrc.2019.09.048  0.76
2019 Ago Y, Tanabe W, Higuchi M, Tsukada S, Tanaka T, Yamaguchi T, Igarashi H, Yokoyama R, Seiriki K, Kasai A, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H. (R)-ketamine induces a greater increase in prefrontal 5-HT release than (S)-ketamine and ketamine metabolites via an AMPA receptor-independent mechanism. The International Journal of Neuropsychopharmacology. PMID 31325908 DOI: 10.1093/ijnp/pyz041  0.48
2019 Nakazawa T, Hashimoto R, Takuma K, Hashimoto H. Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies. Journal of Pharmacological Sciences. PMID 31257060 DOI: 10.1016/j.jphs.2019.06.002  0.48
2019 Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, ... ... Hashimoto H, et al. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31216562 DOI: 10.1038/s41386-019-0441-5  0.52
2019 Kasai A, Seiriki K, Hashimoto H. [Whole-brain activity mapping at single-cell resolution]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 153: 278-283. PMID 31178533 DOI: 10.1254/fpj.153.278  0.4
2019 Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H. Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST. Nature Protocols. PMID 30962606 DOI: 10.1038/s41596-019-0148-4  0.52
2019 Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H. Pituitary adenylate cyclase-activating polypeptide modulates dendritic spine maturation and morphogenesis via microRNA-132 upregulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30886013 DOI: 10.1523/JNEUROSCI.2468-18.2019  0.76
2019 Ivic I, Balasko M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D, Solymár M. VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice. Plos One. 14: e0211433. PMID 30682157 DOI: 10.1371/journal.pone.0211433  0.32
2018 Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H. mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model. Pharmacology, Biochemistry, and Behavior. 176: 1-5. PMID 30419271 DOI: 10.1016/j.pbb.2018.11.003  0.48
2018 Ago Y, Hayata A, Hashimoto H. [Pathophysiological implication of the VPAC2 receptor in psychiatric disorders]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 151: 249-253. PMID 29887574 DOI: 10.1254/fpj.151.249  0.68
2018 Reglodi D, Jungling A, Longuespée R, Kriegsmann J, Casadonte R, Kriegsmann M, Juhasz T, Bardosi S, Tamas A, Fulop BD, Kovacs K, Nagy Z, Sparks J, Miseta A, Mazzucchelli G, ... Hashimoto H, et al. Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes. The Journal of Pathology. PMID 29774542 DOI: 10.1002/path.5100  0.32
2018 Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H. β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. Plos One. 13: e0196946. PMID 29734363 DOI: 10.1371/journal.pone.0196946  0.76
2018 Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, ... Hashimoto H, et al. Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism. Embo Reports. PMID 29371327 DOI: 10.15252/embr.201744860  0.76
2017 Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, et al. Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response. Biochemical and Biophysical Research Communications. PMID 29180011 DOI: 10.1016/j.bbrc.2017.11.116  0.76
2017 Ivic I, Solymar M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D. Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice. Journal of Vascular Research. 54: 359-366. PMID 29131060 DOI: 10.1159/000481781  0.32
2017 Reglodi D, Cseh S, Somoskoi B, Fulop B, Szentleleky E, Szegeczki V, Kovacs A, Varga A, Kiss P, Hashimoto H, Tamas A, Bardosi A, Manavalan S, Bako E, Zakany R, et al. Disturbed spermatogenic signaling in PACAP deficient mice. Reproduction (Cambridge, England). PMID 29101268 DOI: 10.1530/REP-17-0470  0.32
2017 Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Fanselow MS, Hashimoto H, Waschek JA. Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Neurobiology of Learning and Memory. PMID 29030297 DOI: 10.1016/j.nlm.2017.10.010  0.52
2017 Hara Y, Ago Y, Higuchi M, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism. Hormones and Behavior. PMID 28942000 DOI: 10.1016/j.yhbeh.2017.09.013  0.48
2017 Hara Y, Ago Y, Taruta A, Hasebe S, Kawase H, Tanabe W, Tsukada S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice. Psychopharmacology. PMID 28798977 DOI: 10.1007/s00213-017-4703-9  0.48
2017 Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain. Molecular Autism. 8: 33. PMID 28670439 DOI: 10.1186/s13229-017-0149-5  0.48
2017 Yamaguchi H, Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice. Behavioural Brain Research. PMID 28655565 DOI: 10.1016/j.bbr.2017.06.035  0.48
2017 Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, ... ... Hashimoto H, et al. High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates. Neuron. 94: 1085-1100.e6. PMID 28641108 DOI: 10.1016/j.neuron.2017.05.017  0.76
2017 Ago Y, Hasebe S, Hiramatsu N, Hashimoto H, Takuma K, Matsuda T. Psychopharmacology of combined activation of the serotonin1A and σ1 receptors. European Journal of Pharmacology. PMID 28529139 DOI: 10.1016/j.ejphar.2017.05.035  0.48
2017 Ivic I, Fulop BD, Juhasz T, Reglodi D, Toth G, Hashimoto H, Tamas A, Koller A. Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice. Journal of Vascular Research. 54: 180-192. PMID 28490016 DOI: 10.1159/000457798  0.32
2017 Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. The Journal of Experimental Medicine. PMID 28408410 DOI: 10.1084/jem.20161517  0.48
2017 Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, et al. Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. International Journal of Molecular Sciences. 18. PMID 28335437 DOI: 10.3390/ijms18030632  0.36
2017 Farkas J, Sandor B, Tamas A, Kiss P, Hashimoto H, Nagy AD, Fulop BD, Juhasz T, Manavalan S, Reglodi D. Early Neurobehavioral Development of Mice Lacking Endogenous PACAP. Journal of Molecular Neuroscience : Mn. PMID 28168413 DOI: 10.1007/s12031-017-0887-z  0.32
2017 Takuma K, Ago Y, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T. Regulation of emotional behaviors by juvenile environmental factors. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 149: 76-78. PMID 28154301 DOI: 10.1254/fpj.149.76  0.48
2016 Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, ... ... Hashimoto H, et al. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophrenia Research. PMID 28277309 DOI: 10.1016/j.schres.2016.10.012  0.76
2016 Nakata M, Zhang B, Yang Y, Okada T, Shintani N, Hashimoto H, Yada T. High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance. Journal of Diabetes Research. 2016: 9321395. PMID 28044141 DOI: 10.1155/2016/9321395  0.76
2016 Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T. Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice. The International Journal of Neuropsychopharmacology. PMID 28034961 DOI: 10.1093/ijnp/pyw115  0.48
2016 Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H. Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues. Frontiers in Molecular Neuroscience. 9: 126. PMID 27920667 DOI: 10.3389/fnmol.2016.00126  0.76
2016 Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H. Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice. Biochemical and Biophysical Research Communications. PMID 27793672 DOI: 10.1016/j.bbrc.2016.10.089  0.48
2016 Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, ... ... Hashimoto H, et al. Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction. Behavioural Brain Research. PMID 27481693 DOI: 10.1016/j.bbr.2016.07.050  0.72
2016 Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S. PACAP suppresses dry eye signs by stimulating tear secretion. Nature Communications. 7: 12034. PMID 27345595 DOI: 10.1038/ncomms12034  0.72
2016 Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. Psychopharmacology. PMID 27339616 DOI: 10.1007/s00213-016-4353-3  0.72
2016 Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K. Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation. Neurochemical Research. PMID 27300699 DOI: 10.1007/s11064-016-1969-y  0.48
2016 Kormos V, Gáspár L, Kovács L, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglődi D, Helyes Z, Gaszner B. Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers. Neuroscience. PMID 27282087 DOI: 10.1016/j.neuroscience.2016.06.004  0.32
2016 Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H. De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ. Journal of Molecular Psychiatry. 4: 1. PMID 27103995 DOI: 10.1186/s40303-016-0016-x  0.76
2016 Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, ... ... Hashimoto H, et al. Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nature Communications. 7: 11466. PMID 27095349 DOI: 10.1038/ncomms11466  0.36
2016 Ago Y, Hasebe S, Hashimoto H, Takuma K, Matsuda T. The novel method female encounter test . Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 147: 230-4. PMID 27063907 DOI: 10.1254/fpj.147.230  0.48
2016 Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. Scientific Reports. 6: 22373. PMID 26925806 DOI: 10.1038/srep22373  0.4
2016 Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke. Journal of Molecular Neuroscience : Mn. PMID 26910758 DOI: 10.1007/s12031-016-0731-x  0.4
2016 Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, ... ... Hashimoto H, et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nature Communications. 7: 10594. PMID 26839058 DOI: 10.1038/ncomms10594  0.36
2015 Ikeda K, Tomimoto S, Tsuchiya S, Hamagami KI, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H. Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice. Biochemistry and Biophysics Reports. 2: 179-183. PMID 29124161 DOI: 10.1016/j.bbrep.2015.06.006  0.76
2015 Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K. Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. Autism Research : Official Journal of the International Society For Autism Research. PMID 26714434 DOI: 10.1002/aur.1596  0.48
2015 Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K. Structured line illumination Raman microscopy. Nature Communications. 6: 10095. PMID 26626144 DOI: 10.1038/ncomms10095  0.36
2015 Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, ... ... Hashimoto H, et al. Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. Journal of Human Genetics. PMID 26582266 DOI: 10.1038/jhg.2015.141  0.76
2015 Higashino K, Ago Y, Umeki T, Hasebe S, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice. Psychopharmacology. PMID 26518025 DOI: 10.1007/s00213-015-4123-7  0.48
2015 Kawanai T, Taruta A, Inoue A, Watanabe R, Ago Y, Hashimoto H, Hasebe S, Ooi Y, Takuma K, Matsuda T. Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice. Epilepsy Research. 115: 109-12. PMID 26220386 DOI: 10.1016/j.eplepsyres.2015.06.002  0.48
2015 Ago Y, Hasebe S, Nishiyama S, Oka S, Onaka Y, Hashimoto H, Takuma K, Matsuda T. The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 26025781 DOI: 10.1093/ijnp/pyv062  0.48
2015 Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behavioural Pharmacology. 26: 681-90. PMID 25932719 DOI: 10.1097/FBP.0000000000000140  0.72
2015 Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, ... ... Hashimoto H, et al. p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice. Biochemical and Biophysical Research Communications. 461: 612-7. PMID 25912136 DOI: 10.1016/j.bbrc.2015.04.074  0.72
2015 Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T. Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model. Behavioural Brain Research. 289: 39-47. PMID 25907743 DOI: 10.1016/j.bbr.2015.04.022  0.72
2015 Helyes Z, Kun J, Dobrosi N, Sándor K, Németh J, Perkecz A, Pintér E, Szabadfi K, Gaszner B, Tékus V, Szolcsányi J, Steinhoff M, Hashimoto H, Regl?di D, Bíró T. Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema. The Journal of Investigative Dermatology. PMID 25905588 DOI: 10.1038/jid.2015.156  0.72
2015 Tsumuraya T, Ohtaki H, Song D, Sato A, Watanabe J, Hiraizumi Y, Nakamachi T, Xu Z, Dohi K, Hashimoto H, Atsumi T, Shioda S. Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP). Journal of Neuroinflammation. 12: 35. PMID 25889720 DOI: 10.1186/s12974-015-0252-5  0.72
2015 Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB. A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. Plos One. 10: e0121707. PMID 25826270 DOI: 10.1371/journal.pone.0121707  0.72
2015 Ogata K, Shintani N, Hayata-Takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudry D, Vaudry H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, ... ... Hashimoto H, et al. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. Plos One. 10: e0120526. PMID 25807538 DOI: 10.1371/journal.pone.0120526  0.76
2015 Hasebe S, Hiramatsu N, Ago Y, Mori K, Watabe Y, Hashimoto H, Takuma K, Matsuda T. Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice. Journal of Pharmacological Sciences. 127: 232-5. PMID 25727963 DOI: 10.1016/j.jphs.2015.01.001  0.72
2015 Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H. Simultaneous neuron- and astrocyte-specific fluorescent marking. Biochemical and Biophysical Research Communications. 459: 81-6. PMID 25721661 DOI: 10.1016/j.bbrc.2015.02.073  0.72
2015 Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata KY, Nakamura M, Hashimoto R, Matsuda T, Waschek JA, Kasai A, ... ... Hashimoto H, et al. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Behavioural Brain Research. 284: 131-7. PMID 25698598 DOI: 10.1016/j.bbr.2015.02.013  0.72
2015 Ota Y, Ago Y, Tanaka T, Hasebe S, Toratani Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Anxiolytic-like effects of restraint during the dark cycle in adolescent mice. Behavioural Brain Research. 284: 103-11. PMID 25687845 DOI: 10.1016/j.bbr.2015.02.010  0.72
2015 Ago Y, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA. Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist. Psychopharmacology. 232: 2181-9. PMID 25575489 DOI: 10.1007/s00213-014-3848-z  0.72
2015 Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, ... ... Hashimoto H, et al. Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. Journal of Neurochemistry. 132: 418-28. PMID 25421849 DOI: 10.1111/jnc.12999  0.72
2014 Shintani N, Onaka Y, Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, ... ... Hashimoto H, et al. Behavioral characterization of mice overexpressing human dysbindin-1. Molecular Brain. 7: 74. PMID 25298178 DOI: 10.1186/s13041-014-0074-x  0.76
2014 Takuma K, Hara Y, Kataoka S, Kawanai T, Maeda Y, Watanabe R, Takano E, Hayata-Takano A, Hashimoto H, Ago Y, Matsuda T. Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. Pharmacology, Biochemistry, and Behavior. 126: 43-9. PMID 25240644 DOI: 10.1016/j.pbb.2014.08.013  0.72
2014 Botz B, Bölcskei K, Kereskai L, Kovács M, Németh T, Szigeti K, Horváth I, Máthé D, Kovács N, Hashimoto H, ReglÅ‘di D, Szolcsányi J, Pintér E, Mócsai A, Helyes Z. Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model. Arthritis & Rheumatology (Hoboken, N.J.). 66: 2739-50. PMID 25048575 DOI: 10.1002/art.38772  0.72
2014 Takuma K, Maeda Y, Ago Y, Ishihama T, Takemoto K, Nakagawa A, Shintani N, Hashimoto H, Baba A, Matsuda T. An enriched environment ameliorates memory impairments in PACAP-deficient mice. Behavioural Brain Research. 272: 269-78. PMID 25014004 DOI: 10.1016/j.bbr.2014.07.005  0.72
2014 Banki E, Pakai E, Gaszner B, Zsiboras C, Czett A, Bhuddi PR, Hashimoto H, Toth G, Tamas A, Reglodi D, Garami A. Characterization of the thermoregulatory response to pituitary adenylate cyclase-activating polypeptide in rodents. Journal of Molecular Neuroscience : Mn. 54: 543-54. PMID 24994541 DOI: 10.1007/s12031-014-0361-0  0.72
2014 Hazama K, Hayata-Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, Nagayasu K, Hashimoto R, Reglodi D, Miyakawa T, Nakazawa T, Baba A, Hashimoto H. Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice. Plos One. 9: e89153. PMID 24586556 DOI: 10.1371/journal.pone.0089153  0.72
2014 Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata KY, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, et al. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2514-23. PMID 24523542 DOI: 10.1523/JNEUROSCI.1407-13.2014  0.72
2013 Hayata-Takano A, Seiriki K, Tajiri M, Ogata K, Shintani N, Baba A, Hashimoto H. [Pituitary adenylate cyclase-activating polypeptide(PACAP) plays significant roles in mental function and neuronal development]. Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. 33: 73-5. PMID 25314749  0.72
2013 Botz B, Imreh A, Sándor K, Elekes K, Szolcsányi J, ReglÅ‘di D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z. Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. Peptides. 43: 105-12. PMID 23499760 DOI: 10.1016/j.peptides.2013.03.003  0.72
2013 Inoue H, Shintani N, Sakurai Y, Higashi S, Hayata-Takano A, Baba A, Hashimoto H. PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density. Frontiers in Endocrinology. 4: 27. PMID 23483824 DOI: 10.3389/fendo.2013.00027  0.72
2013 Ago Y, Hiramatsu N, Ishihama T, Hazama K, Hayata-Takano A, Shibasaki Y, Shintani N, Hashimoto H, Kawasaki T, Onoe H, Chaki S, Nakazato A, Baba A, Takuma K, Matsuda T. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide. Behavioural Pharmacology. 24: 74-7. PMID 23268987 DOI: 10.1097/FBP.0b013e32835cf3e5  0.72
2013 Arata S, Nakamachi T, Onimaru H, Hashimoto H, Shioda S. Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse. The European Journal of Neuroscience. 37: 407-16. PMID 23136967 DOI: 10.1111/ejn.12054  0.72
2013 Tóth ZE, Heinzlmann A, Hashimoto H, Köves K. Distribution of secretin receptors in the rat central nervous system: an in situ hybridization study. Journal of Molecular Neuroscience : Mn. 50: 172-8. PMID 23065333 DOI: 10.1007/s12031-012-9895-1  0.72
2013 Ago Y, Yano K, Araki R, Hiramatsu N, Kita Y, Kawasaki T, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T. Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. Neuropharmacology. 65: 29-38. PMID 23022081 DOI: 10.1016/j.neuropharm.2012.09.008  0.72
2012 Hattori S, Takao K, Tanda K, Toyama K, Shintani N, Baba A, Hashimoto H, Miyakawa T. Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice. Frontiers in Behavioral Neuroscience. 6: 58. PMID 23060763 DOI: 10.3389/fnbeh.2012.00058  0.72
2012 Tajiri M, Hayata-Takano A, Seiriki K, Ogata K, Hazama K, Shintani N, Baba A, Hashimoto H. Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders. Journal of Molecular Neuroscience : Mn. 48: 473-81. PMID 22843252 DOI: 10.1007/s12031-012-9861-y  0.72
2012 Hashimoto H. [Psychiatric implications of PACAP signaling pathway]. Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. 32: 133-7. PMID 22834101  0.72
2012 Heinzlmann A, Kiss G, Tóth ZE, Dochnal R, Pál Á, Sipos I, Manczinger M, Szabó G, Hashimoto H, Köves K. Intranasal application of secretin, similarly to intracerebroventricular administration, influences the motor behavior of mice probably through specific receptors. Journal of Molecular Neuroscience : Mn. 48: 558-64. PMID 22752505 DOI: 10.1007/s12031-012-9839-9  0.72
2012 Tsuchikawa D, Nakamachi T, Tsuchida M, Wada Y, Hori M, Farkas J, Yoshikawa A, Kagami N, Imai N, Shintani N, Hashimoto H, Atsumi T, Shioda S. Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury. Journal of Molecular Neuroscience : Mn. 48: 508-17. PMID 22674051 DOI: 10.1007/s12031-012-9817-2  0.72
2012 Kawasaki T, Marumo T, Shirakami K, Mori T, Doi H, Suzuki M, Watanabe Y, Chaki S, Nakazato A, Ago Y, Hashimoto H, Matsuda T, Baba A, Onoe H. Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 1737-46. PMID 22669478 DOI: 10.1038/jcbfm.2012.68  0.72
2012 Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami K, Hayata-Takano A, Baba A, Hashimoto H. Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells. Journal of Molecular Neuroscience : Mn. 48: 647-53. PMID 22477644 DOI: 10.1007/s12031-012-9758-9  0.72
2012 Shimada T, Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A, Toi A, Asano K, Shintani N, Hayata-Takano A, Baba A, Hashimoto H. A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells. Journal of Neurochemistry. 122: 81-93. PMID 22404309 DOI: 10.1111/j.1471-4159.2012.07724.x  0.72
2012 Ago Y, Araki R, Yano K, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice. Journal of Pharmacological Sciences. 118: 295-8. PMID 22293290 DOI: JST.JSTAGE/jphs/11200SC  0.72
2012 Haba R, Shintani N, Onaka Y, Wang H, Takenaga R, Hayata A, Baba A, Hashimoto H. Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala. Behavioural Brain Research. 228: 423-31. PMID 22209851 DOI: 10.1016/j.bbr.2011.12.027  0.72
2012 Markovics A, Kormos V, Gaszner B, Lashgarara A, Szoke E, Sandor K, Szabadfi K, Tuka B, Tajti J, Szolcsanyi J, Pinter E, Hashimoto H, Kun J, Reglodi D, Helyes Z. Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice. Neurobiology of Disease. 45: 633-44. PMID 22033344 DOI: 10.1016/j.nbd.2011.10.010  0.72
2011 Vincze A, Reglodi D, Helyes Z, Hashimoto H, Shintani N, Abrahám H. Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: lessons from PACAP-deficient mice. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 29: 923-35. PMID 21726625 DOI: 10.1016/j.ijdevneu.2011.06.008  0.72
2011 Elekes K, Sandor K, Moricz A, Kereskai L, Kemeny A, Szoke E, Perkecz A, Reglodi D, Hashimoto H, Pinter E, Szolcsanyi J, Helyes Z. Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: in vivo study with gene-deleted mice. Peptides. 32: 1439-46. PMID 21605612 DOI: 10.1016/j.peptides.2011.05.008  0.72
2011 Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A. PACAP is implicated in the stress axes. Current Pharmaceutical Design. 17: 985-9. PMID 21524255 DOI: 10.2174/138161211795589382  0.72
2011 Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T. Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. Psychopharmacology. 217: 443-52. PMID 21487651 DOI: 10.1007/s00213-011-2295-3  0.72
2011 Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri M, Hazama K, Ogata K, Hashimoto H, Baba A. PACAP centrally mediates emotional stress-induced corticosterone responses in mice. Stress (Amsterdam, Netherlands). 14: 368-75. PMID 21438773 DOI: 10.3109/10253890.2010.544345  0.72
2011 Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Shintani N, Hashimoto H, Baba A, Takeda M. [Translational research for mental disorder -schizophrenia]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 137: 79-82. PMID 21321456 DOI: JST.JSTAGE/fpj/137.79  0.72
2011 Tanida M, Shintani N, Hashimoto H. The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide. Neuroscience Research. 70: 55-61. PMID 21291921 DOI: 10.1016/j.neures.2011.01.014  0.72
2011 Szakaly P, Laszlo E, Kovacs K, Racz B, Horvath G, Ferencz A, Lubics A, Kiss P, Tamas A, Brubel R, Opper B, Baba A, Hashimoto H, Farkas J, Matkovits A, et al. Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury. Neuropeptides. 45: 113-21. PMID 21211837 DOI: 10.1016/j.npep.2010.12.003  0.72
2011 Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T. Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice. Neuropharmacology. 60: 397-404. PMID 20970439 DOI: 10.1016/j.neuropharm.2010.10.009  0.72
2011 Endo K, Nakamachi T, Seki T, Kagami N, Wada Y, Nakamura K, Kishimoto K, Hori M, Tsuchikawa D, Shinntani N, Hashimoto H, Baba A, Koide R, Shioda S. Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse. Journal of Molecular Neuroscience : Mn. 43: 22-9. PMID 20703829 DOI: 10.1007/s12031-010-9434-x  0.72
2011 Sakurai Y, Shintani N, Hayata A, Hashimoto H, Baba A. Trophic effects of PACAP on pancreatic islets: a mini-review. Journal of Molecular Neuroscience : Mn. 43: 3-7. PMID 20645023 DOI: 10.1007/s12031-010-9424-z  0.72
2011 Sakurai Y, Shintani N, Arimori A, Hamagami K, Higuchi N, Inoue H, Ikeda K, Hayata A, Hashimoto H, Baba A. Cerulein-induced acute pancreatitis in PACAP knockout mice. Journal of Molecular Neuroscience : Mn. 43: 8-15. PMID 20567937 DOI: 10.1007/s12031-010-9396-z  0.72
2010 Purwana IN, Kanasaki H, Oride A, Mijiddorj T, Shintani N, Hashimoto H, Baba A, Miyazaki K. GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: a possible role in the regulation of gonadotropin subunit gene expression. Peptides. 31: 1748-55. PMID 20553777 DOI: 10.1016/j.peptides.2010.05.012  0.72
2010 Nakata M, Shintani N, Hashimoto H, Baba A, Yada T. Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity. Journal of Molecular Neuroscience : Mn. 42: 404-10. PMID 20461496 DOI: 10.1007/s12031-010-9383-4  0.72
2010 Hatanaka M, Shibata N, Shintani N, Haba R, Hayata A, Hashimoto H, Baba A. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. Journal of Pharmacological Sciences. 113: 89-93. PMID 20424389 DOI: JST.JSTAGE/jphs/10001SC  0.72
2010 Kemény A, Reglodi D, Cseharovszky R, Hashimoto H, Baba A, Szolcsányi J, Pintér E, Helyes Z. Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in mice. Journal of Molecular Neuroscience : Mn. 42: 443-9. PMID 20414744 DOI: 10.1007/s12031-010-9368-3  0.72
2010 Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S. Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor. Journal of Molecular Neuroscience : Mn. 42: 397-403. PMID 20387010 DOI: 10.1007/s12031-010-9350-0  0.72
2010 Ferencz A, Weber G, Helyes Z, Hashimoto H, Baba A, Reglodi D. Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury. Journal of Molecular Neuroscience : Mn. 42: 428-34. PMID 20379803 DOI: 10.1007/s12031-010-9352-y  0.72
2010 Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S. Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice. Circulation Journal : Official Journal of the Japanese Circulation Society. 74: 1183-90. PMID 20378996 DOI: JST.JSTAGE/circj/CJ-09-1024  0.72
2010 Kawaguchi C, Isojima Y, Shintani N, Hatanaka M, Guo X, Okumura N, Nagai K, Hashimoto H, Baba A. PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset. Plos One. 5: e9286. PMID 20174586 DOI: 10.1371/journal.pone.0009286  0.72
2010 Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K. Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide. Regulatory Peptides. 161: 73-80. PMID 20171991 DOI: 10.1016/j.regpep.2010.02.002  0.72
2010 Ishihama T, Ago Y, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T. Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice. Behavioural Brain Research. 209: 274-80. PMID 20144662 DOI: 10.1016/j.bbr.2010.02.009  0.72
2010 Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M. Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations. Plos One. 5: e8596. PMID 20062533 DOI: 10.1371/journal.pone.0008596  0.72
2010 Tanaka K, Kunishige-Yamamoto A, Hashimoto H, Shintani N, Hayata A, Baba A. Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice. Biochemical and Biophysical Research Communications. 391: 773-7. PMID 19944672 DOI: 10.1016/j.bbrc.2009.11.136  0.72
2010 Horvath G, Mark L, Brubel R, Szakaly P, Racz B, Kiss P, Tamas A, Helyes Z, Lubics A, Hashimoto H, Baba A, Shintani N, Furjes G, Nemeth J, Reglodi D. Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro. Neuroscience Letters. 469: 70-4. PMID 19932736 DOI: 10.1016/j.neulet.2009.11.046  0.72
2010 Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neuroscience Letters. 468: 300-2. PMID 19914336 DOI: 10.1016/j.neulet.2009.11.019  0.72
2010 Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N, Baba A, Shioda S. Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain. Acta Neurochirurgica. Supplement. 106: 43-6. PMID 19812918 DOI: 10.1007/978-3-211-98811-4_6  0.72
2009 Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, Fournier A, Chow BK, Hashimoto H, Galas L, Vaudry H. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacological Reviews. 61: 283-357. PMID 19805477 DOI: 10.1124/pr.109.001370  0.72
2009 Hamagami K, Sakurai Y, Shintani N, Higuchi N, Ikeda K, Hashimoto H, Suzuki A, Kiyama H, Baba A. Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice. Journal of Pharmacological Sciences. 110: 451-8. PMID 19672038 DOI: JST.JSTAGE/jphs/09119FP  0.72
2009 Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. Journal of Neurochemistry. 110: 595-602. PMID 19457081 DOI: 10.1111/j.1471-4159.2009.06168.x  0.72
2009 Tsuchida R, Kubo M, Shintani N, Abe M, Köves K, Uetsuki K, Kuroda M, Hashimoto H, Baba A. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biological & Pharmaceutical Bulletin. 32: 728-31. PMID 19336914 DOI: JST.JSTAGE/bpb/32.728  0.72
2009 Tsuchida R, Kubo M, Kuroda M, Shibasaki Y, Shintani N, Abe M, Köves K, Hashimoto H, Baba A. An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice. Journal of Pharmacological Sciences. 109: 396-402. PMID 19270432 DOI: JST.JSTAGE/jphs/08297FP  0.72
2008 Hatanaka M, Tanida M, Shintani N, Isojima Y, Kawaguchi C, Hashimoto H, Kakuda M, Haba R, Nagai K, Baba A. Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice. Neuroscience Letters. 444: 153-6. PMID 18722505 DOI: 10.1016/j.neulet.2008.08.030  0.72
2008 Hagi K, Azuma YT, Nakajima H, Shintani N, Hashimoto H, Baba A, Takeuchi T. Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus. European Journal of Pharmacology. 590: 80-6. PMID 18602629 DOI: 10.1016/j.ejphar.2008.05.045  0.72
2008 Kasai A, Shintani N, Kato H, Matsuda S, Gomi F, Haba R, Hashimoto H, Kakuda M, Tano Y, Baba A. Retardation of retinal vascular development in apelin-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1717-22. PMID 18599802 DOI: 10.1161/ATVBAHA.108.163402  0.72
2008 Tomimoto S, Ojika T, Shintani N, Hashimoto H, Hamagami K, Ikeda K, Nakata M, Yada T, Sakurai Y, Shimada T, Morita Y, Ishida C, Baba A. Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice. Journal of Pharmacological Sciences. 107: 41-8. PMID 18446003 DOI: JST.JSTAGE/jphs/FP0072173  0.72
2008 Heinzlmann A, Kirilly E, Meltzer K, Szabó E, Baba A, Hashimoto H, Köves K. PACAP is transiently expressed in anterior pituitary gland of rats: in situ hybridization and cell immunoblot assay studies. Peptides. 29: 571-7. PMID 18243417 DOI: 10.1016/j.peptides.2007.12.009  0.72
2008 Azuma YT, Hagi K, Shintani N, Kuwamura M, Nakajima H, Hashimoto H, Baba A, Takeuchi T. PACAP provides colonic protection against dextran sodium sulfate induced colitis. Journal of Cellular Physiology. 216: 111-9. PMID 18205183 DOI: 10.1002/jcp.21381  0.72
2008 Koda K, Ago Y, Kawasaki T, Hashimoto H, Baba A, Matsuda T. Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice. Psychopharmacology. 196: 293-301. PMID 17912499 DOI: 10.1007/s00213-007-0962-1  0.72
2007 Fujii H, Ishihama T, Ago Y, Shintani N, Kakuda M, Hashimoto H, Baba A, Matsuda T. Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice. Peptides. 28: 1674-9. PMID 17658665 DOI: 10.1016/j.peptides.2007.06.012  0.72
2007 Ago Y, Nakamura S, Kajita N, Uda M, Hashimoto H, Baba A, Matsuda T. Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice. Synapse (New York, N.Y.). 61: 757-63. PMID 17568413 DOI: 10.1002/syn.20421  0.72
2007 Ago Y, Takahashi K, Nakamura S, Hashimoto H, Baba A, Matsuda T. Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test. Journal of Pharmacological Sciences. 104: 153-8. PMID 17538228 DOI: JST.JSTAGE/jphs/FP0070325  0.72
2007 Hashimoto H, Shintani N, Baba A. [Neuropeptide PACAP and neuropsychological function: unexpected insights from mouse mutants]. Seikagaku. the Journal of Japanese Biochemical Society. 79: 375-9. PMID 17511259  0.72
2007 Shintani N, Ogita K, Hashimoto H, Baba A. Recent studies on the trimethyltin actions in central nervous systems. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 127: 451-61. PMID 17329931 DOI: JST.JSTAGE/yakushi/127.451  0.76
2006 Nakamura S, Ago Y, Hayashi A, Itoh S, Kakuda M, Hashimoto H, Baba A, Matsuda T. Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. Synapse (New York, N.Y.). 60: 479-84. PMID 16952156 DOI: 10.1002/syn.20323  0.76
2006 Shintani N, Hashimoto H, Tanaka K, Kawagishi N, Kawaguchi C, Hatanaka M, Ago Y, Matsuda T, Baba A. Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-). Annals of the New York Academy of Sciences. 1070: 545-9. PMID 16888223 DOI: 10.1196/annals.1317.079  0.72
2006 Morita Y, Yanagida D, Shintani N, Ogita K, Nishiyama N, Tsuchida R, Hashimoto H, Baba A. Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice. Annals of the New York Academy of Sciences. 1070: 450-6. PMID 16888208 DOI: 10.1196/annals.1317.060  0.76
2006 Hirose M, Hashimoto H, Iga J, Shintani N, Nakanishi M, Arakawa N, Shimada T, Baba A. Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells. Annals of the New York Academy of Sciences. 1070: 342-7. PMID 16888189 DOI: 10.1196/annals.1317.042  0.76
2006 Hashimoto H, Shintani N, Baba A. New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice. Annals of the New York Academy of Sciences. 1070: 75-89. PMID 16888150 DOI: 10.1196/annals.1317.038  0.76
2006 Tanaka K, Shintani N, Hashimoto H, Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5091-7. PMID 16687500 DOI: 10.1523/JNEUROSCI.4376-05.2006  0.72
2006 Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, Yofu S, Hashimoto H, Shintani N, Baba A, Kopf M, Iwakura Y, Matsuda K, Arimura A, Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proceedings of the National Academy of Sciences of the United States of America. 103: 7488-93. PMID 16651528 DOI: 10.1073/pnas.0600375103  0.76
2006 Toyoshima M, Takeuchi T, Goto H, Mukai K, Shintani N, Hashimoto H, Baba A, Hata F. Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum. PflüGers Archiv : European Journal of Physiology. 451: 559-68. PMID 16292577 DOI: 10.1007/s00424-005-1491-6  0.76
2006 Mukai K, Takeuchi T, Toyoshima M, Satoh Y, Fujita A, Shintani N, Hashimoto H, Baba A, Hata F. PACAP- and PHI-mediated sustained relaxation in circular muscle of gastric fundus: findings obtained in PACAP knockout mice. Regulatory Peptides. 133: 54-61. PMID 16229904 DOI: 10.1016/j.regpep.2005.09.019  0.76
2005 Shintani N, Suetake S, Hashimoto H, Koga K, Kasai A, Kawaguchi C, Morita Y, Hirose M, Sakai Y, Tomimoto S, Matsuda T, Baba A. Neuroprotective action of endogenous PACAP in cultured rat cortical neurons. Regulatory Peptides. 126: 123-8. PMID 15620425 DOI: 10.1016/j.regpep.2004.08.014  0.72
2005 Hirose M, Hashimoto H, Shintani N, Nakanishi M, Arakawa N, Iga J, Niwa H, Miyazaki J, Baba A. Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells. Regulatory Peptides. 126: 109-13. PMID 15620423 DOI: 10.1016/j.regpep.2004.08.018  0.76
2005 Ogawa T, Nakamachi T, Ohtaki H, Hashimoto H, N S, Baba A, Watanabe J, Kikuyama S, Shioda S. Monoaminergic neuronal development is not affected in PACAP-gene-deficient mice. Regulatory Peptides. 126: 103-8. PMID 15620422 DOI: 10.1016/j.regpep.2004.08.034  0.76
2004 Kasai A, Shintani N, Oda M, Kakuda M, Hashimoto H, Matsuda T, Hinuma S, Baba A. Apelin is a novel angiogenic factor in retinal endothelial cells. Biochemical and Biophysical Research Communications. 325: 395-400. PMID 15530405 DOI: 10.1016/j.bbrc.2004.10.042  0.76
2004 Shintani N, Hashimoto H, Tanaka K, Kawaguchi C, Tomimoto S, Baba A. Overexpression of PACAP in the pancreas failed to rescue early postnatal mortality in PACAP-null mice. Regulatory Peptides. 123: 155-9. PMID 15518906 DOI: 10.1016/j.regpep.2004.04.022  0.72
2004 Tanaka K, Hashimoto H, Shintani N, Yamamoto A, Baba A. Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice. Regulatory Peptides. 123: 95-8. PMID 15518898 DOI: 10.1016/j.regpep.2004.05.017  0.76
2004 Nakata M, Kohno D, Shintani N, Nemoto Y, Hashimoto H, Baba A, Yada T. PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Neuroscience Letters. 370: 252-6. PMID 15488333 DOI: 10.1016/j.neulet.2004.08.034  0.76
2004 Mabuchi T, Shintani N, Matsumura S, Okuda-Ashitaka E, Hashimoto H, Muratani T, Minami T, Baba A, Ito S. Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7283-91. PMID 15317855 DOI: 10.1523/JNEUROSCI.0983-04.2004  0.76
2004 Freson K, Hashimoto H, Thys C, Wittevrongel C, Danloy S, Morita Y, Shintani N, Tomiyama Y, Vermylen J, Hoylaerts MF, Baba A, Van Geet C. The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation. The Journal of Clinical Investigation. 113: 905-12. PMID 15067323 DOI: 10.1172/JCI19252  0.76
2004 Shintani N, Hashimoto H, Baba A. [Altered higher brain function in PACAP-knockout mice]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 123: 274-80. PMID 15056943  0.76
2004 Tomimoto S, Hashimoto H, Shintani N, Baba A. [Transgenic mice overexpressing PACAP in pancreatic beta-cells: acute and chronic effects on insulin and glucose homeostasis]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 123: 261-6. PMID 15056941  0.76
2004 Sakai Y, Hashimoto H, Shintani N, Katoh H, Negishi M, Kawaguchi C, Kasai A, Baba A. PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells. Brain Research. Molecular Brain Research. 123: 18-26. PMID 15046862 DOI: 10.1016/j.molbrainres.2003.12.013  0.72
2004 Tomimoto S, Hashimoto H, Shintani N, Yamamoto K, Kawabata Y, Hamagami K, Yamagata K, Miyagawa J, Baba A. Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice. The Journal of Pharmacology and Experimental Therapeutics. 309: 796-803. PMID 14742740 DOI: 10.1124/jpet.103.062919  0.76
2003 Shintani N, Tanaka K, Hashimoto H, Baba A. [Altered behavioral response to centrally acting drugs in mice lacking PACAP]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 122: 1P-4P. PMID 14727506  0.76
2003 Vereczki V, Köves K, Tóth ZE, Baba A, Hashimoto H, Fógel K, Arimura A, Kausz M. Pituitary adenylate cyclase-activating polypeptide does not colocalize with vasoactive intestinal polypeptide in the hypothalamic magnocellular nuclei and posterior pituitary of cats and rats. Endocrine. 22: 225-37. PMID 14709795 DOI: 10.1385/ENDO:22:3:225  0.72
2003 Shintani N, Tomimoto S, Hashimoto H, Kawaguchi C, Baba A. Functional roles of the neuropeptide PACAP in brain and pancreas. Life Sciences. 74: 337-43. PMID 14607262 DOI: 10.1016/j.lfs.2003.09.021  0.72
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