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Michael W. Handlogten, Ph.D. - Publications

Affiliations: 
2013 University of Notre Dame, Notre Dame, IN, United States 
Area:
Biomedical Engineering, Biochemistry, Molecular Biology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Handlogten MW, Bosley S, Dunn S, Zhu J, Lee-O'Brien A, Li L, Therres J, Chakrabarti L, Khanal B, Mowery R, Arumugam S, Klover J, Taleb M, Reier J, Hatton D, et al. Accelerated cell culture process development and characterization for cilgavimab/tixagevimab (AZD7442) for the prevention and treatment of COVID-19. Biotechnology and Bioengineering. PMID 36722717 DOI: 10.1002/bit.28336  0.308
2020 Handlogten MW, Peng L, Christian EA, Xu W, Lin S, Venkat R, Dall'Acqua W, Ahuja S. Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region. Mabs. 12: 1779974. PMID 32633193 DOI: 10.1080/19420862.2020.1779974  0.414
2020 Handlogten MW, Wang J, Ahuja S. Online Control of Cell Culture Redox Potential Prevents Antibody Interchain Disulfide Bond Reduction. Biotechnology and Bioengineering. PMID 31956991 DOI: 10.1002/Bit.27281  0.424
2020 Swope N, Keen Chung W, Cao M, Motabar D, Liu D, Ahuja S, Handlogten M. Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation. Biotechnology and Bioengineering. PMID 31930476 DOI: 10.1002/Bit.27264  0.456
2018 Handlogten MW, Zhu M, Ahuja S. Intracellular response of CHO cells to oxidative stress and its influence on metabolism and antibody production Biochemical Engineering Journal. 133: 12-20. DOI: 10.1016/J.Bej.2018.01.031  0.3
2017 Handlogten MW, Lee-O'Brien A, Roy G, Levitskaya SV, Venkat R, Singh S, Ahuja S. Intracellular Response to Process Optimization and Impact on Productivity and Product Aggregates for a high-titer CHO Cell Process. Biotechnology and Bioengineering. PMID 28941283 DOI: 10.1002/Bit.26460  0.356
2017 Handlogten MW, Zhu M, Ahuja S. Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing. Biotechnology and Bioengineering. PMID 28262915 DOI: 10.1002/Bit.26278  0.444
2017 Chung WK, Russell B, Yang Y, Handlogten M, Hudak S, Cao M, Wang J, Robbins D, Ahuja S, Zhu M. Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability. Biotechnology and Bioengineering. PMID 28186329 DOI: 10.1002/Bit.26265  0.474
2014 Handlogten MW, Deak PE, Bilgicer B. Two-allergen model reveals complex relationship between IgE crosslinking and degranulation. Chemistry & Biology. 21: 1445-51. PMID 25308278 DOI: 10.1016/J.Chembiol.2014.08.019  0.324
2014 Handlogten MW, Stefanick JF, Deak PE, Bilgicer B. Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies. The Analyst. 139: 4247-55. PMID 25006715 DOI: 10.1039/C4An00780H  0.502
2014 Handlogten MW, Serezani AP, Sinn AL, Pollok KE, Kaplan MH, Bilgicer B. A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo. Journal of Immunology (Baltimore, Md. : 1950). 192: 2035-41. PMID 24489096 DOI: 10.4049/Jimmunol.1301371  0.399
2013 Handlogten MW, Kiziltepe T, Serezani AP, Kaplan MH, Bilgicer B. Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation. Nature Chemical Biology. 9: 789-95. PMID 24096304 DOI: 10.1038/Nchembio.1358  0.404
2013 Alves NJ, Cusick W, Stefanick JF, Ashley JD, Handlogten MW, Bilgicer B. Functionalized liposome purification via Liposome Extruder Purification (LEP). The Analyst. 138: 4746-51. PMID 23841107 DOI: 10.1039/C3An00680H  0.584
2013 Alves NJ, Champion MM, Stefanick JF, Handlogten MW, Moustakas DT, Shi Y, Shaw BF, Navari RM, Kiziltepe T, Bilgicer B. Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site. Biomaterials. 34: 5700-10. PMID 23601661 DOI: 10.1016/J.Biomaterials.2013.03.082  0.469
2013 Handlogten MW, Stefanick JF, Alves NJ, Bilgicer B. Nonchromatographic affinity precipitation method for the purification of bivalently active pharmaceutical antibodies from biological fluids. Analytical Chemistry. 85: 5271-8. PMID 23597026 DOI: 10.1021/Ac4008286  0.482
2013 Handlogten MW, Kiziltepe T, Bilgicer B. Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation. The Biochemical Journal. 449: 91-9. PMID 23050868 DOI: 10.1042/Bj20121088  0.439
2012 Alves NJ, Stimple SD, Handlogten MW, Ashley JD, Kiziltepe T, Bilgicer B. Small-molecule-based affinity chromatography method for antibody purification via nucleotide binding site targeting. Analytical Chemistry. 84: 7721-8. PMID 22928545 DOI: 10.1021/Ac300952R  0.617
2012 Handlogten MW, Kiziltepe T, Alves NJ, Bilgicer B. Synthetic allergen design reveals the significance of moderate affinity epitopes in mast cell degranulation. Acs Chemical Biology. 7: 1796-801. PMID 22877585 DOI: 10.1021/Cb300193F  0.335
2012 Kiziltepe T, Ashley JD, Stefanick JF, Qi YM, Alves NJ, Handlogten MW, Suckow MA, Navari RM, Bilgicer B. Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo. Blood Cancer Journal. 2: e64. PMID 22829966 DOI: 10.1038/Bcj.2012.10  0.591
2012 Stefanick JF, Kiziltepe T, Handlogten MW, Alves NJ, Bilgicer B. Enhancement of antibody selectivity via bicyclic complex formation Journal of Physical Chemistry Letters. 3: 598-602. DOI: 10.1021/Jz201682Z  0.424
2011 Handlogten MW, Kiziltepe T, Moustakas DT, Bilgiçer B. Design of a heterobivalent ligand to inhibit IgE clustering on mast cells. Chemistry & Biology. 18: 1179-88. PMID 21944756 DOI: 10.1016/J.Chembiol.2011.06.012  0.37
2010 Paraskar AS, Soni S, Chin KT, Chaudhuri P, Muto KW, Berkowitz J, Handlogten MW, Alves NJ, Bilgicer B, Dinulescu DM, Mashelkar RA, Sengupta S. Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy. Proceedings of the National Academy of Sciences of the United States of America. 107: 12435-40. PMID 20616005 DOI: 10.1073/Pnas.1007026107  0.312
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