Jacquelyn J. Maher, MD - Publications

Internal Medicine, Division of Gastroenterology University of California, San Francisco, San Francisco, CA 
Mechanisms of fatty liver disease

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ. CD18 deficiency improves liver injury in the MCD model of steatohepatitis. Plos One. 12: e0183912. PMID 28873429 DOI: 10.1371/journal.pone.0183912  0.4
2017 Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ. Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice. Cellular and Molecular Gastroenterology and Hepatology. 4: 223-236. PMID 28649594 DOI: 10.1016/j.jcmgh.2017.04.004  0.4
2016 Pierce AA, Duwaerts CC, Soon RK, Siao K, Grenert JP, Fitch M, Hellerstein MK, Beysen C, Turner SM, Maher JJ. Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury. The Journal of Nutritional Biochemistry. 29: 12-20. PMID 26895660 DOI: 10.1016/j.jnutbio.2015.10.020  0.36
2015 Pierce AA, Pickens MK, Siao K, Grenert JP, Maher JJ. Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis. Bmc Gastroenterology. 15: 72. PMID 26103964 DOI: 10.1186/s12876-015-0298-y  0.4
2015 Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology (Baltimore, Md.). 61: 141-52. PMID 25131933 DOI: 10.1002/hep.27379  0.36
2015 Pierce AA, Pickens MK, Siao K, Grenert JP, Maher JJ. Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis Bmc Gastroenterology. 15. DOI: 10.1186/s12876-015-0298-y  0.36
2014 Duwaerts CC, Maher JJ. Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. Current Hepatology Reports. 13: 119-129. PMID 25045618 DOI: 10.1007/s11901-014-0224-8  0.36
2013 Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nature Medicine. 19: 1617-24. PMID 24216753 DOI: 10.1038/nm.3282  0.36
2013 Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton LC, Lefai E, Simon MC, Maher JJ, et al. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nature Medicine. 19: 1331-7. PMID 24037094 DOI: 10.1038/nm.3295  0.36
2013 Maher JJ. Retinol binding protein 4 and fatty liver: A direct link? Hepatology (Baltimore, Md.). 58: 477-9. PMID 23703940 DOI: 10.1002/hep.26507  0.36
2013 Varenika V, Fu Y, Maher JJ, Gao D, Kakar S, Cabarrus MC, Yeh BM. Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT. Radiology. 266: 151-8. PMID 23169796 DOI: 10.1148/radiol.12112452  0.36
2013 Mukhtar NA, Bacchetti P, Ayala CE, Melgar J, Christensen S, Maher JJ, Khalili M. Insulin sensitivity and variability in hepatitis C virus infection using direct measurement. Digestive Diseases and Sciences. 58: 1141-8. PMID 23086116 DOI: 10.1007/s10620-012-2438-3  0.36
2012 Mukhtar NA, Ayala C, Maher JJ, Khalili M. Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action. Journal of Viral Hepatitis. 19: 480-7. PMID 22676360 DOI: 10.1111/j.1365-2893.2011.01568.x  0.36
2012 Nie B, Park HM, Kazantzis M, Lin M, Henkin A, Ng S, Song S, Chen Y, Tran H, Lai R, Her C, Maher JJ, Forman BM, Stahl A. Specific bile acids inhibit hepatic fatty acid uptake in mice. Hepatology (Baltimore, Md.). 56: 1300-10. PMID 22531947 DOI: 10.1002/hep.25797  0.36
2012 Yin C, Evason KJ, Maher JJ, Stainier DY. The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver. Hepatology (Baltimore, Md.). 56: 1958-70. PMID 22488653 DOI: 10.1002/hep.25757  0.36
2012 Brandman D, Bacchetti P, Ayala CE, Maher JJ, Khalili M. Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action. Diabetes Care. 35: 1090-4. PMID 22399695 DOI: 10.2337/dc11-1837  0.36
2012 Schwabe RF, Maher JJ. Lipids in liver disease: looking beyond steatosis. Gastroenterology. 142: 8-11. PMID 22107717 DOI: 10.1053/j.gastro.2011.11.004  0.36
2011 Maher JJ. New insights from rodent models of fatty liver disease. Antioxidants & Redox Signaling. 15: 535-50. PMID 21126212 DOI: 10.1089/ars.2010.3749  0.36
2010 Soon RK, Yan JS, Grenert JP, Maher JJ. Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology. 139: 1730-9, 1739.e1. PMID 20682321 DOI: 10.1053/j.gastro.2010.07.046  0.36
2010 Lam KD, Bacchetti P, Abbasi F, Ayala CE, Loeb SM, Shah V, Wen MJ, Reaven GM, Maher JJ, Khalili M. Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: impact of obesity and ethnicity. Hepatology (Baltimore, Md.). 52: 38-46. PMID 20578127 DOI: 10.1002/hep.23670  0.36
2010 Sheikh-Bahaei S, Maher JJ, Anthony Hunt C. Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity. Journal of Theoretical Biology. 265: 718-33. PMID 20541559 DOI: 10.1016/j.jtbi.2010.06.011  0.36
2010 Pickens MK, Ogata H, Soon RK, Grenert JP, Maher JJ. Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet. Liver International : Official Journal of the International Association For the Study of the Liver. 30: 1229-39. PMID 20536716 DOI: 10.1111/j.1478-3231.2010.02285.x  0.36
2010 Maher JJ. Trunk fat as a determinant of liver disease. Gastroenterology. 138: 1244-6. PMID 20184974 DOI: 10.1053/j.gastro.2010.02.031  0.36
2010 Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ. Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines. The Journal of Surgical Research. 158: 43-52. PMID 19394963 DOI: 10.1016/j.jss.2008.08.030  0.36
2009 Pickens MK, Yan JS, Ng RK, Ogata H, Grenert JP, Beysen C, Turner SM, Maher JJ. Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis. Journal of Lipid Research. 50: 2072-82. PMID 19295183 DOI: 10.1194/jlr.M900022-JLR200  0.36
2009 Maher JJ. DAMPs ramp up drug toxicity. The Journal of Clinical Investigation. 119: 246-9. PMID 19244605 DOI: 10.1172/JCI38178  0.36
2008 Maher JJ, Leon P, Ryan JC. Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 48: 670-8. PMID 18666225 DOI: 10.1002/hep.22399  0.36
2007 Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA. Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 323: 979-89. PMID 17761498 DOI: 10.1124/jpet.107.124602  0.36
2007 Lee GS, Yan JS, Ng RK, Kakar S, Maher JJ. Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury. Journal of Lipid Research. 48: 1885-96. PMID 17526933 DOI: 10.1194/jlr.M700181-JLR200  0.36
2007 Maher JJ. Alcoholic steatohepatitis: management and prognosis. Current Gastroenterology Reports. 9: 39-46. PMID 17335676 DOI: 10.1007/s11894-008-0019-6  0.36
2006 Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ. Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Surgery. 140: 404-12. PMID 16934602 DOI: 10.1016/j.surg.2006.01.021  0.36
2006 Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, Ng RK, Turner SM, Badger TM, Pitas RE, Maher JJ. Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. Journal of Lipid Research. 47: 2280-90. PMID 16829692 DOI: 10.1194/jlr.M600198-JLR200  0.36
2006 Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, ... ... Maher JJ, et al. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine. 12: 793-800. PMID 16799557 DOI: 10.1038/nm1428  0.36
2006 Kodali P, Wu P, Lahiji PA, Brown EJ, Maher JJ. ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. American Journal of Physiology. Gastrointestinal and Liver Physiology. 291: G355-63. PMID 16614373 DOI: 10.1152/ajpgi.00458.2005  0.36
2006 Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Molecular & Cellular Proteomics : McP. 5: 979-86. PMID 16500929 DOI: 10.1074/mcp.M500320-MCP200  0.36
2006 Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU. Metabolic profiling of livers and blood from obese Zucker rats. Journal of Hepatology. 44: 956-62. PMID 16223541 DOI: 10.1016/j.jhep.2005.07.009  0.36
2006 Hanson JC, Bostick MK, Campe CB, Kodali P, Lee G, Yan J, Maher JJ. Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicity. Journal of Hepatology. 44: 359-67. PMID 16168518 DOI: 10.1016/j.jhep.2005.06.022  0.36
2005 Han XM, Lee G, Hefner C, Maher JJ, Correia MA. Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase? The Journal of Pharmacology and Experimental Therapeutics. 314: 128-38. PMID 15769864 DOI: 10.1124/jpet.105.084699  0.36
2004 Xu J, Lee G, Wang H, Vierling JM, Maher JJ. Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G734-41. PMID 15130876 DOI: 10.1152/ajpgi.00300.2003  0.36
2004 Maher JJ. What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis. Hepatology (Baltimore, Md.). 39: 1141-3. PMID 15057918 DOI: 10.1002/hep.20134  0.36
2003 Saito JM, Bostick MK, Campe CB, Xu J, Maher JJ. Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 25: 180-191. PMID 12644055 DOI: 10.1016/S1386-6346(02)00247-4  0.36
2002 Maher JJ. Treatment of alcoholic hepatitis. Journal of Gastroenterology and Hepatology. 17: 448-55. PMID 11982726 DOI: 10.1046/j.1440-1746.2002.02722.x  0.36
2002 Maher JJ. Alcoholic steatosis and steatohepatitis. Seminars in Gastrointestinal Disease. 13: 31-9. PMID 11944632  0.36
2002 Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. The Journal of Biological Chemistry. 277: 5476-83. PMID 11739387 DOI: 10.1074/jbc.M108514200  0.36
2001 Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. The Journal of Biological Chemistry. 276: 49077-82. PMID 11602613 DOI: 10.1074/jbc.M109791200  0.36
2001 Maher JJ. Interactions between hepatic stellate cells and the immune system. Seminars in Liver Disease. 21: 417-26. PMID 11586469 DOI: 10.1055/s-2001-17555  0.36
2001 Maher J, Deleve L, Crabb D, Dibisceglie A, Keeffe E, Lavine J, Nathanson M, Rockey D, Thiele D, Bhattacharya R, Kowdley KV. Liver transplantation in the elderly: Is caution warranted? Hepatology. 34: 604-605. PMID 11526549 DOI: 10.1053/jhep.2001.0340604  0.36
2001 Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. The Journal of Biological Chemistry. 276: 34434-40. PMID 11457847 DOI: 10.1074/jbc.M105025200  0.36
2001 Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. The Journal of Cell Biology. 153: 1023-34. PMID 11381087 DOI: 10.1083/jcb.153.5.1023  0.36
2001 Maher J, DeLeve L, Crabb D, DiBisceglie A, Keeffe E, Lavine J, Nathanson M, Rockey D, Thiele D. Antidiabetic treatment for nash? Hepatology. 33: 1338-1339. PMID 11343267 DOI: 10.1053/jhep.2001.0331338  0.36
2001 Maher J. The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis Hepatology. 33: 311-312. PMID 11124851 DOI: 10.1053/JHEP.2001.0330311  0.36
2000 Friedman SL, Maher JJ, Bissell DM. Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference. Hepatology (Baltimore, Md.). 32: 1403-8. PMID 11093750 DOI: 10.1053/jhep.2000.20243  0.36
2000 Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology. 118: 1157-68. PMID 10833491  0.36
1999 Maher JJ. Cytokines: overview. Seminars in Liver Disease. 19: 109-15. PMID 10422194 DOI: 10.1055/s-2007-1007103  0.36
1999 Maher J, Schwarzenberg SJ. Congenital hepatic fibrosis - Is it really a matter of 'a spoonful of sugar?' Hepatology. 30: 582-583. PMID 10421674 DOI: 10.1002/hep.510300239  0.36
1999 Maher JJ. Leukocytes as modulators of stellate cell activation. Alcoholism, Clinical and Experimental Research. 23: 917-21. PMID 10371414  0.36
1998 Maher JJ. How does estrogen enhance endotoxin toxicity? Let me count the ways. Hepatology (Baltimore, Md.). 28: 1720-1. PMID 9828242 DOI: 10.1002/hep.510280638  0.36
1998 Maher JJ, Lozier JS, Scott MK. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. The American Journal of Physiology. 275: G847-53. PMID 9756517  0.36
1998 Maher JJ, Gores GJ. Apoptosis: silent killer or neutron bomb? Hepatology (Baltimore, Md.). 28: 865-7. PMID 9731584 DOI: 10.1002/hep.510280338  0.36
1997 Maher JJ. Exploring alcohol's effects on liver function. Alcohol Health and Research World. 21: 5-12. PMID 15706758  0.36
1997 Maher JJ, Neuschwander-Tetri BA. Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis. Hepatology (Baltimore, Md.). 26: 618-23. PMID 9303491 DOI: 10.1002/hep.510260313  0.36
1997 Maher JJ, Saito JM, Neuschwander-Tetri BA. Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo. Biochemical Pharmacology. 53: 637-41. PMID 9113082 DOI: 10.1016/S0006-2952(96)00865-9  0.36
1997 Maher JJ, Scott MK, Saito JM, Burton MC. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis. Hepatology (Baltimore, Md.). 25: 624-30. PMID 9049209 DOI: 10.1002/hep.510250322  0.36
1995 Maher JJ. Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol. The American Journal of Physiology. 269: G518-23. PMID 7485503  0.36
1994 Maher JJ, Tzagarakis C. Partial cloning of the M subunit of laminin from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver. Hepatology (Baltimore, Md.). 19: 764-70. PMID 8119705  0.36
1994 Maher JJ, Zia S, Tzagarakis C. Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts. Alcoholism, Clinical and Experimental Research. 18: 403-9. PMID 8048746  0.36
1994 Maher JJ, Tzagarakis C, Giménez A. Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture. Alcohol and Alcoholism (Oxford, Oxfordshire). 29: 605-10. PMID 7811345  0.36
1993 Maher JJ, Friedman SL. Parenchymal and nonparenchymal cell interactions in the liver. Seminars in Liver Disease. 13: 13-20. PMID 8446905 DOI: 10.1055/s-2007-1007334  0.36
1993 Maher JJ, Bissell DM. Cell-matrix interactions in liver. Seminars in Cell Biology. 4: 189-201. PMID 7688595  0.36
1993 Maher JJ. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. The Journal of Clinical Investigation. 91: 2244-52. PMID 7683700 DOI: 10.1172/JCI116451  0.36
1992 Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology (Baltimore, Md.). 15: 234-43. PMID 1735526  0.36
1992 Maher JJ. Yet another role for the "good" matrix protein: laminin in regenerating liver. Hepatology (Baltimore, Md.). 15: 164-6. PMID 1727793  0.36
1992 Rockey DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL. Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma. Hepatology (Baltimore, Md.). 16: 776-84. PMID 1505921 DOI: 10.1002/HEP.1840160325  0.36
1992 Maher JJ. Drug therapy for hepatic fibrosis Hospital Formulary. 27: 269-286.  0.36
1990 Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. The Journal of Clinical Investigation. 86: 1641-8. PMID 2243137 DOI: 10.1172/JCI114886  0.36
1990 Maher JJ. Hepatic fibrosis caused by alcohol. Seminars in Liver Disease. 10: 66-74. PMID 2186489 DOI: 10.1055/s-2008-1040458  0.36
1990 Bissell DM, Friedman SL, Maher JJ, Roll FJ. Connective tissue biology and hepatic fibrosis: report of a conference. Hepatology (Baltimore, Md.). 11: 488-98. PMID 2179098  0.36
1989 Maher JJ. Fat-storing cells and myofibroblasts: one cell or two? Hepatology (Baltimore, Md.). 9: 903-4. PMID 2714742  0.36
1988 Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology. 94: 1053-62. PMID 3278941  0.36
1988 Maher JJ. Primary hepatocyte culture: is it home away from home? Hepatology (Baltimore, Md.). 8: 1162-6. PMID 3047039  0.36
1988 Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. The Journal of Clinical Investigation. 82: 450-9. PMID 3042806 DOI: 10.1172/JCI113618  0.36
1987 Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. The Journal of Clinical Investigation. 79: 801-12. PMID 3546380 DOI: 10.1172/JCI112887  0.36
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