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Jeremy R. Edgerton, Ph.D. - Publications

Affiliations: 
2003 Duke University, Durham, NC 
Area:
Neuroscience Biology
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12/28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Thorn C, Popiolek M, Stark E, Edgerton J. Effects of M1 and M4 activation on excitatory synaptic transmission in CA1. Hippocampus. PMID 28422371 DOI: 10.1002/hipo.22732  0.363
2014 Edgerton JR, Jaeger D. Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation. Frontiers in Cellular Neuroscience. 8: 36. PMID 24574972 DOI: 10.3389/fncel.2014.00036  0.304
2012 Schultheiss NW, Edgerton JR, Jaeger D. Robustness, variability, phase dependence, and longevity of individual synaptic input effects on spike timing during fluctuating synaptic backgrounds: a modeling study of globus pallidus neuron phase response properties. Neuroscience. 219: 92-110. PMID 22659567 DOI: 10.1016/j.neuroscience.2012.05.059  0.3
2011 Edgerton JR, Jaeger D. Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10919-36. PMID 21795543 DOI: 10.1523/JNEUROSCI.6062-10.2011  0.57
2011 Hendrickson EB, Edgerton JR, Jaeger D. The use of automated parameter searches to improve ion channel kinetics for neural modeling. Journal of Computational Neuroscience. 31: 329-46. PMID 21243419 DOI: 10.1007/S10827-010-0312-X  0.54
2010 Edgerton JR, Hanson JE, Günay C, Jaeger D. Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15146-59. PMID 21068320 DOI: 10.1523/JNEUROSCI.2662-10.2010  0.626
2010 Schultheiss NW, Edgerton JR, Jaeger D. Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2767-82. PMID 20164360 DOI: 10.1523/JNEUROSCI.3959-09.2010  0.373
2010 Schultheiss NW, Edgerton JR, Jaeger D. Phase response analysis during in vivo-like high conductance states; dendritic SK determines the mean and variance of responses to dendritic excitation Bmc Neuroscience. 11. DOI: 10.1186/1471-2202-11-S1-O12  0.311
2009 Schultheiss NW, Edgerton JR, Jaeger D. Phase response analysis of a morphological globus pallidus neuron model during irregular spiking: intrinsic and synaptic mechanisms Bmc Neuroscience. 10. DOI: 10.1186/1471-2202-10-S1-P227  0.345
2008 Günay C, Edgerton JR, Jaeger D. Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7476-91. PMID 18650326 DOI: 10.1523/JNEUROSCI.4198-07.2008  0.399
2007 Günay C, Edgerton JR, Jaeger D. Characterizing the heterogeneity of globus pallidus neuron behavior by comparing a real neuron database with model databases of varying conductance parameters Bmc Neuroscience. 8. DOI: 10.1186/1471-2202-8-S2-P123  0.407
1997 Lin Z, Haus S, Edgerton J, Lipscombe D. Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain. Neuron. 18: 153-66. PMID 9010213 DOI: 10.1016/S0896-6273(01)80054-4  0.559
Low-probability matches (unlikely to be authored by this person)
2011 Hendrickson EB, Edgerton JR, Jaeger D. The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. Journal of Computational Neuroscience. 30: 301-21. PMID 20623167 DOI: 10.1007/S10827-010-0258-Z  0.297
2007 Schultheiss NW, Edgerton JR, Jaeger D. Phase response curve analysis of a morphologically realistic globus pallidus neuron model reveals a distal dendritic mechanism for synchronization Bmc Neuroscience. 8. DOI: 10.1186/1471-2202-8-S2-S22  0.256
2007 Hendrickson E, Edgerton J, Gunay C, Schultheiss N, Jaeger D. Converting a globus pallidus neuron model from 585 to 6 compartments using an evolutionary algorithm Bmc Neuroscience. 8. DOI: 10.1186/1471-2202-8-S2-P122  0.25
2018 Thorn CA, Moon J, Bourbonais CA, Harms J, Edgerton JR, Stark E, Steyn SJ, Butler CR, Lazzaro JT, O'Connor RE, Popiolek M. Striatal, hippocampal and cortical networks are differentially responsive to the M4- and M1-muscarinic acetylcholine receptor mediated effects of xanomeline. Acs Chemical Neuroscience. PMID 30480428 DOI: 10.1021/acschemneuro.8b00625  0.166
2009 Günay C, Edgerton JR, Li S, Sangrey T, Prinz AA, Jaeger D. Database analysis of simulated and recorded electrophysiological datasets with PANDORA's toolbox. Neuroinformatics. 7: 93-111. PMID 19475520 DOI: 10.1007/s12021-009-9048-z  0.151
2016 Popiolek M, Nguyen DP, Reinhart V, Edgerton JR, Harms J, Lotarski SM, Steyn SJ, Davoren JE, Grimwood S. Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation. Biochemistry. PMID 27958713 DOI: 10.1021/Acs.Biochem.6B00688  0.139
2017 Davoren JE, Garnsey M, Pettersen B, Brodney MA, Edgerton JR, Fortin JP, Grimwood S, Harris AR, Jenkinson S, Kenakin TP, Lazzaro JT, Lee CW, Lotarski SM, Nottebaum L, O'Neil SV, et al. Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity. Journal of Medicinal Chemistry. PMID 28598634 DOI: 10.1021/Acs.Jmedchem.7B00597  0.135
2003 Edgerton JR, Reinhart PH. Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. The Journal of Physiology. 548: 53-69. PMID 12576503 DOI: 10.1111/J.1469-7793.2003.00053.X  0.115
2016 Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin T, Lazzaro JT, Lotarski SM, Mao Y, et al. Discovery of the potent and selective M1 PAM-agonist N-[(3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of efficacy and cholinergic side effects. Journal of Medicinal Chemistry. PMID 27275946 DOI: 10.1021/Acs.Jmedchem.6B00544  0.109
2023 Eklund NM, Ouillon J, Pandey V, Stephen CD, Schmahmann JD, Edgerton J, Gajos KZ, Gupta AS. Real-life ankle submovements and computer mouse use reflect patient-reported function in adult ataxias. Brain Communications. 5: fcad064. PMID 36993945 DOI: 10.1093/braincomms/fcad064  0.104
2015 Davoren JE, O'Neil SV, Anderson DP, Brodney MA, Chenard L, Dlugolenski K, Edgerton JR, Green M, Garnsey M, Grimwood S, Harris AR, Kauffman GW, LaChapelle E, Lazzaro JT, Lee CW, et al. Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. PMID 26631313 DOI: 10.1016/J.Bmcl.2015.11.053  0.098
1996 Meaking WS, Edgerton J, Wharton CW, Meldrum RA. Electroporation-induced damage in mammalian cell DNA. Biochimica Et Biophysica Acta. 1264: 357-62. PMID 8547324 DOI: 10.1016/0167-4781(95)00177-8  0.077
2008 Hendrickson EB, Edgerton JR, Jaeger D. A general method for creating realistic reduced compartmental models from electrophysiological traces Bmc Neuroscience. 9. DOI: 10.1186/1471-2202-9-S1-P83  0.076
2019 Thorn CA, Moon J, Bourbonais CA, Harms J, Edgerton JR, Stark E, Steyn SJ, Butler CR, Lazzaro JT, O'Connor RE, Popiolek M. Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline. Acs Chemical Neuroscience. PMID 31286767 DOI: 10.1021/acschemneuro.9b00335  0.073
2016 Smith DL, Davoren JE, Edgerton JR, Lazzaro JT, Lee CW, Neal S, Zhang L, Grimwood S. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) Radioligand, [3H]PT-1284. Molecular Pharmacology. PMID 27382013 DOI: 10.1124/Mol.116.104737  0.056
2013 Rizzo SJ, Edgerton JR, Hughes ZA, Brandon NJ. Future viable models of psychiatry drug discovery in pharma. Journal of Biomolecular Screening. 18: 509-21. PMID 23392517 DOI: 10.1177/1087057113475871  0.041
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