David Carling, Ph.D. - Publications

Clinical Sciences Centre 
Metabolic signalling

168 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Nguyen-Tu MS, Harris J, Martinez-Sanchez A, Chabosseau P, Hu M, Georgiadou E, Pollard A, Otero P, Lopez-Noriega L, Leclerc I, Sakamoto K, Schmoll D, Smith DM, Carling D, Rutter GA. Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase. Diabetologia. PMID 35294578 DOI: 10.1007/s00125-022-05673-x  0.382
2021 Wilson L, Pollard A, Penfold L, Muckett P, Whilding C, Bohlooly-Y M, Wilson PD, Carling D. Chronic activation of AMP-activated protein kinase leads to early onset polycystic kidney phenotype. Clinical Science (London, England : 1979). PMID 34622923 DOI: 10.1042/CS20210821  0.315
2020 Spengler K, Zibrova D, Woods A, Langendorf CG, Scott JW, Carling D, Heller R. Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495. The Biochemical Journal. PMID 32869834 DOI: 10.1042/Bcj20200555  0.521
2020 Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, Ng AYJ, Tohari S, Changede R, Carling D, Venkatesh B, Altunoglu U, Kayserili H, Reversade B. A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling. The Journal of Experimental Medicine. 217. PMID 32845958 DOI: 10.1084/Jem.20191561  0.397
2020 Seneviratne A, Cave L, Hyde G, Moestrup SK, Carling D, Mason JC, Haskard DO, Boyle JJ. Metformin directly suppresses atherosclerosis in normoglycemic mice via haematopoietic Adenosine Monophosphate-Activated Protein Kinase (AMPK). Cardiovascular Research. PMID 32667970 DOI: 10.1093/Cvr/Cvaa171  0.405
2020 Seneviratne AN, Han Y, Wong E, Walter ER, Jiang L, Cave L, Long NJ, Carling D, Mason JC, Haskard DO, Boyle JJ. Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1 (ATF1). Circulation Research. PMID 32611235 DOI: 10.1161/Circresaha.119.315528  0.328
2019 Steinberg GR, Carling D. AMP-activated protein kinase: the current landscape for drug development. Nature Reviews. Drug Discovery. PMID 30867601 DOI: 10.1038/S41573-019-0019-2  0.502
2019 Boyle J, Seneviratne A, Han Y, Jiang L, Walter E, Cave L, Shaikh A, Long N, Carling D, Mason J, Haskard D. Vertebrate Hematoma Resolution Is Directed By Activating Transcription Factor 1 (Atf1) And Adenosine-Monophosphate-Activated-Protein-Kinase (Ampk) Atherosclerosis. 287: e246. DOI: 10.1016/J.Atherosclerosis.2019.06.755  0.511
2018 Carling D, Penfold L, Woods A, Muckett P, Nikitin AY, Kent TR, Zhang S, Graham R, Pollard A. CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis. Cancer Research. PMID 30242113 DOI: 10.1158/0008-5472.Can-18-0585  0.312
2018 Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP. Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. The Journal of Biological Chemistry. PMID 30232152 DOI: 10.1074/Jbc.Ra118.002579  0.433
2018 Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM. Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical Journal. PMID 30135087 DOI: 10.1042/Bcj20180475  0.532
2017 Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, ... ... Carling D, et al. Mammalian γ2 AMPK regulates intrinsic heart rate. Nature Communications. 8: 1258. PMID 29097735 DOI: 10.1038/S41467-017-01342-5  0.612
2017 Willows R, Sanders MJ, Xiao B, Patel BR, Martin SR, Read J, Wilson JR, Hubbard J, Gamblin SJ, Carling D. Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells. The Biochemical Journal. PMID 28694351 DOI: 10.1042/Bcj20170458  0.584
2017 Woods A, Williams JR, Muckett PJ, Mayer FV, Liljevald M, Bohlooly-Y M, Carling D. Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet. Cell Reports. 18: 3043-3051. PMID 28355557 DOI: 10.1016/J.Celrep.2017.03.011  0.372
2017 Willows R, Navaratnam N, Lima A, Read J, Carling D. Effect of different γ subunit isoforms on the regulation of AMPK. The Biochemical Journal. PMID 28302767 DOI: 10.1042/Bcj20170046  0.471
2017 Carling D. AMPK signalling in health and disease. Current Opinion in Cell Biology. 45: 31-37. PMID 28232179 DOI: 10.1016/J.Ceb.2017.01.005  0.463
2016 Chennell G, Willows RJ, Warren SC, Carling D, French PM, Dunsby C, Sardini A. Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM. Sensors (Basel, Switzerland). 16. PMID 27548185 DOI: 10.3390/S16081312  0.358
2016 Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, ... ... Carling D, et al. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27303042 DOI: 10.1073/Pnas.1607592113  0.462
2016 Trousil S, Kaliszczak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. PMID 27206796 DOI: 10.18632/Oncotarget.9466  0.38
2016 Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, ... ... Carling D, et al. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metabolism. PMID 27133129 DOI: 10.1016/J.Cmet.2016.04.003  0.412
2016 Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH. AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nature Communications. 7: 10856. PMID 26952277 DOI: 10.1038/Ncomms10856  0.542
2015 Carling D, Viollet B. Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism. Cell Metabolism. 21: 799-804. PMID 26039446 DOI: 10.1016/J.Cmet.2015.05.005  0.527
2015 Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ. Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. Cell Reports. 11: 335-43. PMID 25865886 DOI: 10.1016/J.Celrep.2015.03.029  0.317
2015 Rousset CI, Leiper FC, Kichev A, Gressens P, Carling D, Hagberg H, Thornton C. A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice. Journal of Neurochemistry. 133: 242-52. PMID 25598140 DOI: 10.1111/Jnc.13034  0.607
2015 Hussain S, Richardson E, Ma Y, Holton C, De Backer I, Buckley N, Dhillo W, Bewick G, Zhang S, Carling D, Bloom S, Gardiner J. Glucokinase activity in the arcuate nucleus regulates glucose intake. The Journal of Clinical Investigation. 125: 337-49. PMID 25485685 DOI: 10.1172/Jci77172  0.35
2015 Trousil S, Kalisczcak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, et al. Abstract C118: Choline kinase inhibition with the novel pharmacological inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C118  0.427
2014 Ye T, Bendrioua L, Carmena D, García-Salcedo R, Dahl P, Carling D, Hohmann S. The mammalian AMP-activated protein kinase complex mediates glucose regulation of gene expression in the yeast Saccharomyces cerevisiae. Febs Letters. 588: 2070-7. PMID 24815694 DOI: 10.1016/J.Febslet.2014.04.039  0.51
2014 Wan X, Huo Y, Johns M, Piper E, Mason J, Carling D, Haskard D, Boyle J. Heme and metformin coordinate human and murine macrophage heme oxygenase 1 expression with foam cell resistance partly via adenosine monophosphate kinase and activating transcription factor 1 (AMPK-ATF1) Atherosclerosis. 232: e4. DOI: 10.1016/J.Atherosclerosis.2013.11.010  0.427
2013 Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ. Structural basis of AMPK regulation by small molecule activators. Nature Communications. 4: 3017. PMID 24352254 DOI: 10.1038/Ncomms4017  0.689
2013 Wan X, Huo Y, Johns M, Piper E, Mason JC, Carling D, Haskard DO, Boyle JJ. 5'-AMP-activated protein kinase-activating transcription factor 1 cascade modulates human monocyte-derived macrophages to atheroprotective functions in response to heme or metformin. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2470-80. PMID 24051143 DOI: 10.1161/Atvbaha.113.300986  0.479
2013 Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. The Journal of Clinical Investigation. 123: 2764-72. PMID 23863634 DOI: 10.1172/Jci67227  0.349
2013 Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Research. 73: 5253-65. PMID 23774215 DOI: 10.1158/0008-5472.Can-12-3690  0.364
2013 Zhao J, Carling D, Wang Z, Muckett P, Leiper J, Woods A. Loss of CaMKKβ attenuates endotoxin induced hypotension The Lancet. 381: S119. DOI: 10.1016/S0140-6736(13)60559-0  0.355
2012 Carling D, Thornton C, Woods A, Sanders MJ. AMP-activated protein kinase: new regulation, new roles? The Biochemical Journal. 445: 11-27. PMID 22702974 DOI: 10.1042/Bj20120546  0.644
2012 Woods A, Leiper JM, Carling D. The role of ATM in response to metformin treatment and activation of AMPK. Nature Genetics. 44: 360-1. PMID 22456733 DOI: 10.1038/Ng.2235  0.338
2012 Oliveira SM, Zhang YH, Solis RS, Isackson H, Bellahcene M, Yavari A, Pinter K, Davies JK, Ge Y, Ashrafian H, Walker JW, Carling D, Watkins H, Casadei B, Redwood C. AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. Circulation Research. 110: 1192-201. PMID 22456184 DOI: 10.1161/Circresaha.111.259952  0.474
2012 Fritah A, Steel JH, Parker N, Nikolopoulou E, Christian M, Carling D, Parker MG. Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK. Plos One. 7: e32520. PMID 22389706 DOI: 10.1371/Journal.Pone.0032520  0.393
2012 Tsuchiya Y, Denison FC, Heath RB, Carling D, Saggerson D. 5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes. Bioscience Reports. 32: 197-213. PMID 21851339 DOI: 10.1042/Bsr20110076  0.577
2011 Denison FC, Smith LB, Muckett PJ, O'Hara L, Carling D, Woods A. LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis. Plos One. 6: e28306. PMID 22145035 DOI: 10.1371/Journal.Pone.0028306  0.384
2011 Mayer FV, Heath R, Underwood E, Sanders MJ, Carmena D, McCartney RR, Leiper FC, Xiao B, Jing C, Walker PA, Haire LF, Ogrodowicz R, Martin SR, Schmidt MC, Gamblin SJ, ... Carling D, et al. ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase. Cell Metabolism. 14: 707-14. PMID 22019086 DOI: 10.1016/J.Cmet.2011.09.009  0.568
2011 Hardie DG, Carling D, Gamblin SJ. AMP-activated protein kinase: also regulated by ADP? Trends in Biochemical Sciences. 36: 470-7. PMID 21782450 DOI: 10.1016/J.Tibs.2011.06.004  0.507
2011 Carling D, Mayer FV, Sanders MJ, Gamblin SJ. AMP-activated protein kinase: nature's energy sensor. Nature Chemical Biology. 7: 512-8. PMID 21769098 DOI: 10.1038/Nchembio.610  0.531
2011 Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, et al. Structure of mammalian AMPK and its regulation by ADP. Nature. 472: 230-3. PMID 21399626 DOI: 10.1038/Nature09932  0.53
2011 Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, ... ... Carling D, et al. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes. 60: 735-45. PMID 21266325 DOI: 10.2337/Db10-1055  0.38
2011 Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. The Biochemical Journal. 434: 503-12. PMID 21204788 DOI: 10.1042/Bj20101485  0.757
2011 Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, Ashworth A, Withers DJ, Carling D. LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. The Biochemical Journal. 434: 49-60. PMID 21118154 DOI: 10.1042/Bj20101721  0.305
2010 López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine. 16: 1001-8. PMID 20802499 DOI: 10.1038/Nm.2207  0.389
2010 Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (New York, N.Y.). 329: 1201-5. PMID 20647423 DOI: 10.1126/Science.1191241  0.519
2010 Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML. Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. The Biochemical Journal. 429: 323-33. PMID 20465544 DOI: 10.1042/Bj20100231  0.38
2010 Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, Viollet B, Carling D, Heller R. Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. The Journal of Biological Chemistry. 285: 10638-52. PMID 20129920 DOI: 10.1074/Jbc.M110.108688  0.438
2010 Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. The Embo Journal. 29: 376-86. PMID 19927127 DOI: 10.1038/Emboj.2009.342  0.456
2010 García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochemical Pharmacology. 79: 853-63. PMID 19896469 DOI: 10.1016/J.Bcp.2009.10.022  0.417
2009 Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, ... ... Carling D, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (New York, N.Y.). 326: 140-4. PMID 19797661 DOI: 10.1126/Science.1177221  0.447
2009 Renz B, Davies JK, Carling D, Watkins H, Redwood C. Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: a cautionary tale. Protein Expression and Purification. 66: 181-4. PMID 19269329 DOI: 10.1016/J.Pep.2009.02.016  0.532
2009 Bright NJ, Thornton C, Carling D. The regulation and function of mammalian AMPK-related kinases. Acta Physiologica (Oxford, England). 196: 15-26. PMID 19245655 DOI: 10.1111/J.1748-1716.2009.01971.X  0.757
2009 Carling D. Branching out on AMPK Regulation. Cell Metabolism. 9: 7-8. PMID 19117541 DOI: 10.1016/J.Cmet.2008.12.007  0.461
2009 Denison FC, Hiscock NJ, Carling D, Woods A. Characterization of an alternative splice variant of LKB1. The Journal of Biological Chemistry. 284: 67-76. PMID 18854309 DOI: 10.1074/Jbc.M806153200  0.544
2008 Sag D, Carling D, Stout RD, Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. Journal of Immunology (Baltimore, Md. : 1950). 181: 8633-41. PMID 19050283 DOI: 10.4049/Jimmunol.181.12.8633  0.366
2008 Carling D, Sanders MJ, Woods A. The regulation of AMP-activated protein kinase by upstream kinases. International Journal of Obesity (2005). 32: S55-9. PMID 18719600 DOI: 10.1038/Ijo.2008.124  0.611
2008 López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, ... ... Carling D, et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metabolism. 7: 389-99. PMID 18460330 DOI: 10.1016/J.Cmet.2008.03.006  0.391
2008 Thornton C, Sardini A, Carling D. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. The Journal of Biological Chemistry. 283: 17116-22. PMID 18436530 DOI: 10.1074/Jbc.M708987200  0.66
2008 Bright NJ, Carling D, Thornton C. Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. The Journal of Biological Chemistry. 283: 14946-54. PMID 18339622 DOI: 10.1074/Jbc.M710381200  0.774
2007 Carling D. The role of the AMP-activated protein kinase in the regulation of energy homeostasis. Novartis Foundation Symposium. 286: 72-81; discussion 81. PMID 18269175 DOI: 10.1002/9780470985571.Ch7  0.595
2007 Dranchak PK, Leiper FC, Valberg SJ, Piercy RJ, Carling D, McCue ME, Mickelson JR. Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses. American Journal of Veterinary Research. 68: 1079-84. PMID 17916014 DOI: 10.2460/Ajvr.68.10.1079  0.399
2007 Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong YC, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, Combs TP. Low utilization of circulating glucose after food withdrawal in Snell dwarf mice. The Journal of Biological Chemistry. 282: 35069-77. PMID 17905742 DOI: 10.1074/Jbc.M700484200  0.341
2007 Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, Gamblin SJ. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature. 449: 496-500. PMID 17851531 DOI: 10.1038/Nature06161  0.489
2007 Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling D. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. The Journal of Biological Chemistry. 282: 32539-48. PMID 17728241 DOI: 10.1074/Jbc.M706543200  0.531
2007 Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, ... Carling D, et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. The Journal of Clinical Investigation. 117: 2325-36. PMID 17671657 DOI: 10.1172/Jci31516  0.366
2007 Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, Miraux S, Thiaudière E, Foretz M, Viollet B, Diolez P, Bastin J, Benit P, Rustin P, Carling D, et al. S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metabolism. 5: 476-87. PMID 17550782 DOI: 10.1016/J.Cmet.2007.05.006  0.492
2007 Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz P. A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits. The Journal of Biological Chemistry. 282: 16117-25. PMID 17403675 DOI: 10.1074/Jbc.M611804200  0.373
2007 Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes. 56: 1387-94. PMID 17287464 DOI: 10.2337/Db06-1580  0.384
2007 Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, et al. Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron. 53: 233-47. PMID 17224405 DOI: 10.1016/J.Neuron.2006.12.015  0.391
2007 Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. The Biochemical Journal. 403: 139-48. PMID 17147517 DOI: 10.1042/Bj20061520  0.594
2007 Carling D. AMP‐activated protein kinase and the regulation of energy metabolism The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A206-D  0.486
2006 Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism. 4: 465-74. PMID 17141630 DOI: 10.1016/J.Cmet.2006.11.005  0.372
2006 Stahmann N, Woods A, Carling D, Heller R. Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. Molecular and Cellular Biology. 26: 5933-45. PMID 16880506 DOI: 10.1128/Mcb.00383-06  0.57
2006 Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. American Journal of Physiology. Heart and Circulatory Physiology. 291: H1927-34. PMID 16648175 DOI: 10.1152/Ajpheart.00251.2006  0.403
2006 Carling D. LKB1: a sweet side to Peutz-Jeghers syndrome? Trends in Molecular Medicine. 12: 144-7. PMID 16530014 DOI: 10.1016/J.Molmed.2006.02.003  0.425
2006 Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, Rider MH. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. The Journal of Biological Chemistry. 281: 5335-40. PMID 16340011 DOI: 10.1074/Jbc.M506850200  0.567
2006 Davies JK, Wells DJ, Liu K, Whitrow HR, Daniel TD, Grignani R, Lygate CA, Schneider JE, Noël G, Watkins H, Carling D. Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1942-51. PMID 16339829 DOI: 10.1152/Ajpheart.01020.2005  0.459
2005 Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metabolism. 2: 21-33. PMID 16054096 DOI: 10.1016/J.Cmet.2005.06.005  0.591
2005 Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism. 1: 15-25. PMID 16054041 DOI: 10.1016/J.Cmet.2004.12.003  0.471
2005 Fryer LG, Carling D. AMP-activated protein kinase and the metabolic syndrome. Biochemical Society Transactions. 33: 362-6. PMID 15787607 DOI: 10.1042/Bst0330362  0.462
2005 Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D, Richter EA. Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity. Biochemical and Biophysical Research Communications. 329: 719-25. PMID 15737645 DOI: 10.1016/J.Bbrc.2005.02.027  0.388
2005 Carling D. AMP-activated protein kinase: balancing the scales. Biochimie. 87: 87-91. PMID 15733742 DOI: 10.1016/J.Biochi.2004.10.017  0.57
2005 Sidhu JS, Rajawat YS, Rami TG, Gollob MH, Wang Z, Yuan R, Marian AJ, DeMayo FJ, Weilbacher D, Taffet GE, Davies JK, Carling D, Khoury DS, Roberts R. Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Circulation. 111: 21-9. PMID 15611370 DOI: 10.1161/01.Cir.0000151291.32974.D5  0.364
2004 Small CJ, Carling D, Bloom SR. Cellular energy sensor balances the scales. Nature Medicine. 10: 681-2. PMID 15229514 DOI: 10.1038/Nm0704-681  0.36
2004 Clark H, Carling D, Saggerson D. Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids. European Journal of Biochemistry / Febs. 271: 2215-24. PMID 15153111 DOI: 10.1111/J.1432-1033.2004.04151.X  0.506
2004 Carling D. AMPK. Current Biology : Cb. 14: R220. PMID 15043827 DOI: 10.1016/j.cub.2004.02.048  0.34
2004 Cheng SW, Fryer LG, Carling D, Shepherd PR. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. The Journal of Biological Chemistry. 279: 15719-22. PMID 14970221 DOI: 10.1074/Jbc.C300534200  0.559
2004 Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ. AMP-activated protein kinase plays a role in the control of food intake. The Journal of Biological Chemistry. 279: 12005-8. PMID 14742438 DOI: 10.1074/Jbc.C300557200  0.399
2004 Carling D. The AMP-activated protein kinase cascade--a unifying system for energy control. Trends in Biochemical Sciences. 29: 18-24. PMID 14729328 DOI: 10.1016/J.Tibs.2003.11.005  0.525
2004 Cantó C, Suárez E, Lizcano JM, Griñó E, Shepherd PR, Fryer LG, Carling D, Bertran J, Palacín M, Zorzano A, Gumà A. Neuregulin signaling on glucose transport in muscle cells. The Journal of Biological Chemistry. 279: 12260-8. PMID 14711829 DOI: 10.1074/Jbc.M308554200  0.38
2003 Carling D, Fryer LG, Woods A, Daniel T, Jarvie SL, Whitrow H. Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase. Biochemical Society Transactions. 31: 1157-60. PMID 14641016 DOI: 10.1042/Bst0311157  0.505
2003 Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Current Biology : Cb. 13: 2004-8. PMID 14614828 DOI: 10.1016/J.Cub.2003.10.031  0.597
2003 Neumann D, Woods A, Carling D, Wallimann T, Schlattner U. Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expression and Purification. 30: 230-7. PMID 12880772 DOI: 10.1016/S1046-5928(03)00126-8  0.468
2003 Hong SP, Leiper FC, Woods A, Carling D, Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proceedings of the National Academy of Sciences of the United States of America. 100: 8839-43. PMID 12847291 DOI: 10.1073/Pnas.1533136100  0.594
2003 Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carling D, Rider MH. Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. The Journal of Biological Chemistry. 278: 28434-42. PMID 12764152 DOI: 10.1074/Jbc.M303946200  0.545
2003 Wang W, Yang X, López de Silanes I, Carling D, Gorospe M. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. The Journal of Biological Chemistry. 278: 27016-23. PMID 12730239 DOI: 10.1074/Jbc.M300318200  0.497
2003 Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochemical Society Transactions. 31: 202-6. PMID 12546685 DOI: 10.1042/Bst0310202  0.471
2003 Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. The Journal of Clinical Investigation. 111: 91-8. PMID 12511592 DOI: 10.1172/Jci16567  0.394
2003 Halse R, Fryer LG, McCormack JG, Carling D, Yeaman SJ. Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase. Diabetes. 52: 9-15. PMID 12502487 DOI: 10.2337/Diabetes.52.1.9  0.463
2003 Davies JK, Carling D. Transgenic mice over-expressing the γ2 subunit of AMP-activated protein kinase: a model of hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome Journal of Cardiac Failure. 9: S7. DOI: 10.1016/S1071-9164(03)00187-8  0.447
2002 Brandão RL, Etchebehere L, Queiroz CC, Trópia MJ, Ernandes JR, Gonçalves T, Loureiro-Dias MC, Winderickx J, Thevelein JM, Leiper FC, Carling D, Castro IM. Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2. Fems Yeast Research. 2: 93-102. PMID 12702297 DOI: 10.1111/J.1567-1364.2002.Tb00074.X  0.459
2002 Salgado AP, Schuller D, Casal M, Leão C, Leiper FC, Carling D, Fietto LG, Trópia MJ, Castro IM, Brandão RL. Relationship between protein kinase C and derepression of different enzymes. Febs Letters. 532: 324-32. PMID 12482587 DOI: 10.1016/S0014-5793(02)03695-5  0.482
2002 Fryer LG, Parbu-Patel A, Carling D. Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. Febs Letters. 531: 189-92. PMID 12417310 DOI: 10.1016/S0014-5793(02)03501-9  0.564
2002 Daniel T, Carling D. Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. The Journal of Biological Chemistry. 277: 51017-24. PMID 12397075 DOI: 10.1074/Jbc.M207093200  0.41
2002 Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, ... Carling D, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine. 8: 1288-95. PMID 12368907 DOI: 10.1038/Nm788  0.464
2002 Barnes BR, Ryder JW, Steiler TL, Fryer LG, Carling D, Zierath JR. Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction. Diabetes. 51: 2703-8. PMID 12196462 DOI: 10.2337/Diabetes.51.9.2703  0.406
2002 Barnes K, Ingram JC, Porras OH, Barros LF, Hudson ER, Fryer LG, Foufelle F, Carling D, Hardie DG, Baldwin SA. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). Journal of Cell Science. 115: 2433-42. PMID 12006627  0.443
2002 Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. The Journal of Biological Chemistry. 277: 25226-32. PMID 11994296 DOI: 10.1074/Jbc.M202489200  0.572
2002 Wang W, Fan J, Yang X, Fürer-Galban S, Lopez de Silanes I, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe M. AMP-activated kinase regulates cytoplasmic HuR. Molecular and Cellular Biology. 22: 3425-36. PMID 11971974 DOI: 10.1128/Mcb.22.10.3425-3436.2002  0.445
2002 Daniel T, Carling D. Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits. The Biochemical Journal. 365: 629-38. PMID 11971761 DOI: 10.1042/Bj20020124  0.576
2002 Fryer LG, Foufelle F, Barnes K, Baldwin SA, Woods A, Carling D. Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. The Biochemical Journal. 363: 167-74. PMID 11903059 DOI: 10.1042/Bj3630167  0.481
2002 Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 415: 339-43. PMID 11797013 DOI: 10.1038/415339A  0.488
2002 Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 51: 159-67. PMID 11756336 DOI: 10.2337/Diabetes.51.1.159  0.456
2001 Marsin A, Bertrand L, Beauloye C, Rider MH, Carling D, Hue L. Phosphorylation and activation of heart PFK-2 by AMPK plays a role in the stimulation of glycolysis during ischemia Journal of Molecular and Cellular Cardiology. 33. DOI: 10.1016/S0022-2828(01)90656-X  0.447
2001 Jarvie S, Bayliss J, Carling D. Investigation of AMP-activated protein kinase gamma subunit isoforms Journal of Molecular and Cellular Cardiology. 33: A170. DOI: 10.1016/S0022-2828(01)90653-4  0.547
2001 Carling D. Studies on AMP-activated protein kinase using a mouse muscle cell line Journal of Molecular and Cellular Cardiology. 33: A146. DOI: 10.1016/S0022-2828(01)90560-7  0.471
2000 Fryer LG, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, Carling D. Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes. 49: 1978-85. PMID 11117997 DOI: 10.2337/Diabetes.49.12.1978  0.421
2000 Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue L. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Current Biology : Cb. 10: 1247-55. PMID 11069105 DOI: 10.1016/S0960-9822(00)00742-9  0.553
2000 Woods A, Azzout-Marniche D, Foretz M, Stein SC, Lemarchand P, Ferré P, Foufelle F, Carling D. Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Molecular and Cellular Biology. 20: 6704-11. PMID 10958668 DOI: 10.1128/Mcb.20.18.6704-6711.2000  0.485
2000 Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. The Biochemical Journal. 346: 659-69. PMID 10698692 DOI: 10.1042/Bj3460659  0.433
2000 Stein SC, Woods A, Jones NA, Davison MD, Carling D. The regulation of AMP-activated protein kinase by phosphorylation. The Biochemical Journal. 345: 437-43. PMID 10642499 DOI: 10.1042/Bj3450437  0.57
1999 Blázquez C, Woods A, de Ceballos ML, Carling D, Guzmán M. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. Journal of Neurochemistry. 73: 1674-82. PMID 10501215 DOI: 10.1046/J.1471-4159.1999.731674.X  0.46
1999 Smith FC, Davies SP, Wilson WA, Carling D, Hardie DG. The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. Febs Letters. 453: 219-23. PMID 10403407 DOI: 10.1016/S0014-5793(99)00725-5  0.523
1998 Velasco G, Gómez del Pulgar T, Carling D, Guzmán M. Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. Febs Letters. 439: 317-20. PMID 9845345 DOI: 10.1016/S0014-5793(98)01400-8  0.532
1998 Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annual Review of Biochemistry. 67: 821-55. PMID 9759505 DOI: 10.1146/Annurev.Biochem.67.1.821  0.569
1998 Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. The Biochemical Journal. 334: 177-87. PMID 9693118 DOI: 10.1042/Bj3340177  0.424
1998 Foretz M, Carling D, Guichard C, Ferré P, Foufelle F. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. The Journal of Biological Chemistry. 273: 14767-71. PMID 9614076 DOI: 10.1074/Jbc.273.24.14767  0.508
1998 Thornton C, Snowden MA, Carling D. Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. The Journal of Biological Chemistry. 273: 12443-50. PMID 9575201 DOI: 10.1074/Jbc.273.20.12443  0.557
1998 Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. The Embo Journal. 17: 1688-99. PMID 9501090 DOI: 10.1093/Emboj/17.6.1688  0.537
1997 Cheung PC, Carling D. Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues. Biochemical Society Transactions. 25: S668. PMID 9450096 DOI: 10.1042/Bst025S668  0.573
1997 Thornton C, Snowden MA, Carling D. Identification of a novel AMPK beta subunit that is highly expressed in skeletal muscle. Biochemical Society Transactions. 25: S667. PMID 9450095 DOI: 10.1042/Bst025S667  0.481
1997 Carling D, Woods A, Thornton C, Cheung PC, Smith FC, Ponticos M, Stein SC. Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism. Biochemical Society Transactions. 25: 1224-8. PMID 9449980 DOI: 10.1042/Bst0251224  0.653
1997 Hardie DG, Carling D. The AMP-activated protein kinase--fuel gauge of the mammalian cell? European Journal of Biochemistry / Febs. 246: 259-73. PMID 9208914 DOI: 10.1111/J.1432-1033.1997.00259.X  0.595
1997 Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW. Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase. Febs Letters. 403: 254-8. PMID 9091312 DOI: 10.1016/S0014-5793(97)00062-8  0.557
1997 Cfcheung P, Carling D. 140 Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues Biochemical Society Transactions. 25: S669.  0.401
1997 Thornton C, Snowden MA, Carling D. 139 identification of a novel ampkβ subunit that is highly expressed in skeletal muscle Biochemical Society Transactions. 25: S668.  0.409
1996 Marley AE, Sullivan JE, Carling D, Abbott WM, Smith GJ, Taylor IW, Carey F, Beri RK. Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha. The Biochemical Journal. 320: 801-6. PMID 9003365 DOI: 10.1042/Bj3200801  0.445
1996 Woods A, Salt I, Scott J, Hardie DG, Carling D. The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. Febs Letters. 397: 347-51. PMID 8955377 DOI: 10.1016/S0014-5793(96)01209-4  0.358
1996 Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. The Journal of Biological Chemistry. 271: 27879-87. PMID 8910387 DOI: 10.1074/Jbc.271.44.27879  0.573
1996 Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK, Carling D. Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. The Journal of Biological Chemistry. 271: 10282-90. PMID 8626596 DOI: 10.1074/Jbc.271.17.10282  0.511
1995 Verhoeven AJ, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D. The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. European Journal of Biochemistry / Febs. 228: 236-43. PMID 7705334 DOI: 10.1111/J.1432-1033.1995.Tb20255.X  0.417
1995 Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. The Journal of Biological Chemistry. 270: 27186-91. PMID 7592975 DOI: 10.1074/Jbc.270.45.27186  0.548
1995 Verhoeven AJM, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D. The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle Febs Journal. 228: 236-243. DOI: 10.1111/J.1432-1033.1995.0236N.X  0.417
1994 Sullivan JE, Carey F, Carling D, Beri RK. Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity. Biochemical and Biophysical Research Communications. 200: 1551-6. PMID 8185610 DOI: 10.1006/Bbrc.1994.1627  0.366
1994 Davies SP, Hawley SA, Woods A, Carling D, Haystead TA, Hardie DG. Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. European Journal of Biochemistry / Febs. 223: 351-7. PMID 8055903 DOI: 10.1111/J.1432-1033.1994.Tb19001.X  0.475
1994 Beri RK, Marley AE, See CG, Sopwith WF, Aguan K, Carling D, Scott J, Carey F. Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. Febs Letters. 356: 117-21. PMID 7988703 DOI: 10.1016/0014-5793(94)01247-4  0.347
1994 Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. Febs Letters. 353: 33-6. PMID 7926017 DOI: 10.1016/0014-5793(94)01006-4  0.568
1994 Woods A, Munday MR, Scott J, Yang X, Carlson M, Carling D. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. The Journal of Biological Chemistry. 269: 19509-15. PMID 7913470  0.46
1994 Carling D, Aguan K, Woods A, Verhoeven AJ, Beri RK, Brennan CH, Sidebottom C, Davison MD, Scott J. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. The Journal of Biological Chemistry. 269: 11442-8. PMID 7908907  0.467
1994 Hardie DG, Carling D, Halford N. Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. Seminars in Cell Biology. 5: 409-16. PMID 7711289 DOI: 10.1006/Scel.1994.1048  0.418
1994 Sullivan J, Brocklehurst K, Marley A, Carey F, Carling D, Beri R. Characterization of 5′-AMP activated protein kinase in human liver using specific peptide substrates and the effects of 5′-AMP analogues on enzyme activity in vitro and in primary rat adipocytes Atherosclerosis. 109: 119. DOI: 10.1016/0021-9150(94)93488-6  0.445
1994 Beri R, Marley A, Sopwith W, Aguan K, Carling D, Scott J, Carey F. Human AMP-activated protein kinase: cloning, expression and chromosomal localization Atherosclerosis. 109: 104. DOI: 10.1016/0021-9150(94)93428-2  0.44
1992 Davies SP, Carling D, Munday MR, Hardie DG. Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. European Journal of Biochemistry / Febs. 203: 615-23. PMID 1346520 DOI: 10.1111/J.1432-1033.1992.Tb16591.X  0.568
1991 Carling D, Clarke PR, Hardie DG. Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase. Methods in Enzymology. 200: 362-71. PMID 1683469 DOI: 10.1016/0076-6879(91)00153-N  0.483
1989 Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. European Journal of Biochemistry / Febs. 186: 129-36. PMID 2598924 DOI: 10.1111/J.1432-1033.1989.Tb15186.X  0.557
1989 Davies SP, Carling D, Hardie DG. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. European Journal of Biochemistry / Febs. 186: 123-8. PMID 2574667 DOI: 10.1111/J.1432-1033.1989.Tb15185.X  0.526
1989 Carling D, Hardie DG. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochimica Et Biophysica Acta. 1012: 81-6. PMID 2567185 DOI: 10.1016/0167-4889(89)90014-1  0.475
1989 Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337: 78-81. PMID 2562908 DOI: 10.1038/337078A0  0.491
1989 Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. European Journal of Biochemistry / Febs. 179: 249-54. PMID 2537200 DOI: 10.1111/J.1432-1033.1989.Tb14548.X  0.535
1989 Grahame Hardie D, Carling D, T.R. Sim A. The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism Trends in Biochemical Sciences. 14: 20-23. DOI: 10.1016/0968-0004(89)90084-4  0.506
1988 Munday MR, Carling D, Hardie DG. Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. Febs Letters. 235: 144-8. PMID 2900158 DOI: 10.1016/0014-5793(88)81251-1  0.519
1988 Munday MR, Campbell DG, Carling D, Hardie DG. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. European Journal of Biochemistry / Febs. 175: 331-8. PMID 2900138 DOI: 10.1111/J.1432-1033.1988.Tb14201.X  0.536
1987 Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. Febs Letters. 223: 217-22. PMID 2889619 DOI: 10.1016/0014-5793(87)80292-2  0.531
1986 Hardie DG, Carling D, Ferrari S, Guy PS, Aitken A. Characterization of the phosphorylation of rat mammary ATP-citrate lyase and acetyl-CoA carboxylase by Ca2+ and calmodulin-dependent multiprotein kinase and Ca2+ and phospholipid-dependent protein kinase. European Journal of Biochemistry / Febs. 157: 553-61. PMID 2873035 DOI: 10.1111/J.1432-1033.1986.Tb09702.X  0.542
1986 Carling D, Hardie DG. Isolation of a cyclic-AMP-independent protein kinase from rat liver and its effect on the enzymic activity of acetyl-CoA carboxylase Biochemical Society Transactions. 14: 1076-1077. DOI: 10.1042/Bst0141076  0.444
Show low-probability matches.