| Year |
Citation |
Score |
| 2024 |
Bustraan S, Bennett J, Whilding C, Pennycook B, Smith D, Barr A, Read J, Carling D, Pollard AE. AMPK activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes. The Biochemical Journal. PMID 38314646 DOI: 10.1042/BCJ20240003 |
0.339 |
|
| 2022 |
Nguyen-Tu MS, Harris J, Martinez-Sanchez A, Chabosseau P, Hu M, Georgiadou E, Pollard A, Otero P, Lopez-Noriega L, Leclerc I, Sakamoto K, Schmoll D, Smith DM, Carling D, Rutter GA. Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase. Diabetologia. PMID 35294578 DOI: 10.1007/s00125-022-05673-x |
0.382 |
|
| 2021 |
Wilson L, Pollard A, Penfold L, Muckett P, Whilding C, Bohlooly-Y M, Wilson PD, Carling D. Chronic activation of AMP-activated protein kinase leads to early onset polycystic kidney phenotype. Clinical Science (London, England : 1979). PMID 34622923 DOI: 10.1042/CS20210821 |
0.315 |
|
| 2020 |
Spengler K, Zibrova D, Woods A, Langendorf CG, Scott JW, Carling D, Heller R. Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495. The Biochemical Journal. PMID 32869834 DOI: 10.1042/Bcj20200555 |
0.521 |
|
| 2020 |
Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, Ng AYJ, Tohari S, Changede R, Carling D, Venkatesh B, Altunoglu U, Kayserili H, Reversade B. A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling. The Journal of Experimental Medicine. 217. PMID 32845958 DOI: 10.1084/Jem.20191561 |
0.397 |
|
| 2020 |
Seneviratne A, Cave L, Hyde G, Moestrup SK, Carling D, Mason JC, Haskard DO, Boyle JJ. Metformin directly suppresses atherosclerosis in normoglycemic mice via haematopoietic Adenosine Monophosphate-Activated Protein Kinase (AMPK). Cardiovascular Research. PMID 32667970 DOI: 10.1093/Cvr/Cvaa171 |
0.405 |
|
| 2020 |
Seneviratne AN, Han Y, Wong E, Walter ER, Jiang L, Cave L, Long NJ, Carling D, Mason JC, Haskard DO, Boyle JJ. Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1 (ATF1). Circulation Research. PMID 32611235 DOI: 10.1161/Circresaha.119.315528 |
0.328 |
|
| 2019 |
Steinberg GR, Carling D. AMP-activated protein kinase: the current landscape for drug development. Nature Reviews. Drug Discovery. PMID 30867601 DOI: 10.1038/S41573-019-0019-2 |
0.502 |
|
| 2019 |
Boyle J, Seneviratne A, Han Y, Jiang L, Walter E, Cave L, Shaikh A, Long N, Carling D, Mason J, Haskard D. Vertebrate Hematoma Resolution Is Directed By Activating Transcription Factor 1 (Atf1) And Adenosine-Monophosphate-Activated-Protein-Kinase (Ampk) Atherosclerosis. 287: e246. DOI: 10.1016/J.Atherosclerosis.2019.06.755 |
0.511 |
|
| 2018 |
Carling D, Penfold L, Woods A, Muckett P, Nikitin AY, Kent TR, Zhang S, Graham R, Pollard A. CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis. Cancer Research. PMID 30242113 DOI: 10.1158/0008-5472.Can-18-0585 |
0.312 |
|
| 2018 |
Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP. Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. The Journal of Biological Chemistry. PMID 30232152 DOI: 10.1074/Jbc.Ra118.002579 |
0.433 |
|
| 2018 |
Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM. Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical Journal. PMID 30135087 DOI: 10.1042/Bcj20180475 |
0.532 |
|
| 2017 |
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, ... ... Carling D, et al. Mammalian γ2 AMPK regulates intrinsic heart rate. Nature Communications. 8: 1258. PMID 29097735 DOI: 10.1038/S41467-017-01342-5 |
0.612 |
|
| 2017 |
Willows R, Sanders MJ, Xiao B, Patel BR, Martin SR, Read J, Wilson JR, Hubbard J, Gamblin SJ, Carling D. Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells. The Biochemical Journal. PMID 28694351 DOI: 10.1042/Bcj20170458 |
0.584 |
|
| 2017 |
Woods A, Williams JR, Muckett PJ, Mayer FV, Liljevald M, Bohlooly-Y M, Carling D. Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet. Cell Reports. 18: 3043-3051. PMID 28355557 DOI: 10.1016/J.Celrep.2017.03.011 |
0.372 |
|
| 2017 |
Willows R, Navaratnam N, Lima A, Read J, Carling D. Effect of different γ subunit isoforms on the regulation of AMPK. The Biochemical Journal. PMID 28302767 DOI: 10.1042/Bcj20170046 |
0.471 |
|
| 2017 |
Carling D. AMPK signalling in health and disease. Current Opinion in Cell Biology. 45: 31-37. PMID 28232179 DOI: 10.1016/J.Ceb.2017.01.005 |
0.463 |
|
| 2016 |
Chennell G, Willows RJ, Warren SC, Carling D, French PM, Dunsby C, Sardini A. Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM. Sensors (Basel, Switzerland). 16. PMID 27548185 DOI: 10.3390/S16081312 |
0.358 |
|
| 2016 |
Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, ... ... Carling D, et al. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27303042 DOI: 10.1073/Pnas.1607592113 |
0.462 |
|
| 2016 |
Trousil S, Kaliszczak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. PMID 27206796 DOI: 10.18632/Oncotarget.9466 |
0.38 |
|
| 2016 |
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, ... ... Carling D, et al. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metabolism. PMID 27133129 DOI: 10.1016/J.Cmet.2016.04.003 |
0.412 |
|
| 2016 |
Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH. AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nature Communications. 7: 10856. PMID 26952277 DOI: 10.1038/Ncomms10856 |
0.542 |
|
| 2015 |
Carling D, Viollet B. Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism. Cell Metabolism. 21: 799-804. PMID 26039446 DOI: 10.1016/J.Cmet.2015.05.005 |
0.527 |
|
| 2015 |
Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ. Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. Cell Reports. 11: 335-43. PMID 25865886 DOI: 10.1016/J.Celrep.2015.03.029 |
0.317 |
|
| 2015 |
Rousset CI, Leiper FC, Kichev A, Gressens P, Carling D, Hagberg H, Thornton C. A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice. Journal of Neurochemistry. 133: 242-52. PMID 25598140 DOI: 10.1111/Jnc.13034 |
0.607 |
|
| 2015 |
Hussain S, Richardson E, Ma Y, Holton C, De Backer I, Buckley N, Dhillo W, Bewick G, Zhang S, Carling D, Bloom S, Gardiner J. Glucokinase activity in the arcuate nucleus regulates glucose intake. The Journal of Clinical Investigation. 125: 337-49. PMID 25485685 DOI: 10.1172/Jci77172 |
0.35 |
|
| 2015 |
Trousil S, Kalisczcak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, et al. Abstract C118: Choline kinase inhibition with the novel pharmacological inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C118 |
0.427 |
|
| 2014 |
Ye T, Bendrioua L, Carmena D, GarcÃa-Salcedo R, Dahl P, Carling D, Hohmann S. The mammalian AMP-activated protein kinase complex mediates glucose regulation of gene expression in the yeast Saccharomyces cerevisiae. Febs Letters. 588: 2070-7. PMID 24815694 DOI: 10.1016/J.Febslet.2014.04.039 |
0.51 |
|
| 2014 |
Wan X, Huo Y, Johns M, Piper E, Mason J, Carling D, Haskard D, Boyle J. Heme and metformin coordinate human and murine macrophage heme oxygenase 1 expression with foam cell resistance partly via adenosine monophosphate kinase and activating transcription factor 1 (AMPK-ATF1) Atherosclerosis. 232: e4. DOI: 10.1016/J.Atherosclerosis.2013.11.010 |
0.427 |
|
| 2013 |
Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ. Structural basis of AMPK regulation by small molecule activators. Nature Communications. 4: 3017. PMID 24352254 DOI: 10.1038/Ncomms4017 |
0.689 |
|
| 2013 |
Wan X, Huo Y, Johns M, Piper E, Mason JC, Carling D, Haskard DO, Boyle JJ. 5'-AMP-activated protein kinase-activating transcription factor 1 cascade modulates human monocyte-derived macrophages to atheroprotective functions in response to heme or metformin. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2470-80. PMID 24051143 DOI: 10.1161/Atvbaha.113.300986 |
0.479 |
|
| 2013 |
Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. The Journal of Clinical Investigation. 123: 2764-72. PMID 23863634 DOI: 10.1172/Jci67227 |
0.349 |
|
| 2013 |
Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Research. 73: 5253-65. PMID 23774215 DOI: 10.1158/0008-5472.Can-12-3690 |
0.364 |
|
| 2013 |
Zhao J, Carling D, Wang Z, Muckett P, Leiper J, Woods A. Loss of CaMKKβ attenuates endotoxin induced hypotension The Lancet. 381: S119. DOI: 10.1016/S0140-6736(13)60559-0 |
0.355 |
|
| 2012 |
Carling D, Thornton C, Woods A, Sanders MJ. AMP-activated protein kinase: new regulation, new roles? The Biochemical Journal. 445: 11-27. PMID 22702974 DOI: 10.1042/Bj20120546 |
0.644 |
|
| 2012 |
Woods A, Leiper JM, Carling D. The role of ATM in response to metformin treatment and activation of AMPK. Nature Genetics. 44: 360-1. PMID 22456733 DOI: 10.1038/Ng.2235 |
0.338 |
|
| 2012 |
Oliveira SM, Zhang YH, Solis RS, Isackson H, Bellahcene M, Yavari A, Pinter K, Davies JK, Ge Y, Ashrafian H, Walker JW, Carling D, Watkins H, Casadei B, Redwood C. AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. Circulation Research. 110: 1192-201. PMID 22456184 DOI: 10.1161/Circresaha.111.259952 |
0.474 |
|
| 2012 |
Fritah A, Steel JH, Parker N, Nikolopoulou E, Christian M, Carling D, Parker MG. Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK. Plos One. 7: e32520. PMID 22389706 DOI: 10.1371/Journal.Pone.0032520 |
0.393 |
|
| 2012 |
Tsuchiya Y, Denison FC, Heath RB, Carling D, Saggerson D. 5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes. Bioscience Reports. 32: 197-213. PMID 21851339 DOI: 10.1042/Bsr20110076 |
0.577 |
|
| 2011 |
Denison FC, Smith LB, Muckett PJ, O'Hara L, Carling D, Woods A. LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis. Plos One. 6: e28306. PMID 22145035 DOI: 10.1371/Journal.Pone.0028306 |
0.384 |
|
| 2011 |
Mayer FV, Heath R, Underwood E, Sanders MJ, Carmena D, McCartney RR, Leiper FC, Xiao B, Jing C, Walker PA, Haire LF, Ogrodowicz R, Martin SR, Schmidt MC, Gamblin SJ, ... Carling D, et al. ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase. Cell Metabolism. 14: 707-14. PMID 22019086 DOI: 10.1016/J.Cmet.2011.09.009 |
0.567 |
|
| 2011 |
Hardie DG, Carling D, Gamblin SJ. AMP-activated protein kinase: also regulated by ADP? Trends in Biochemical Sciences. 36: 470-7. PMID 21782450 DOI: 10.1016/J.Tibs.2011.06.004 |
0.507 |
|
| 2011 |
Carling D, Mayer FV, Sanders MJ, Gamblin SJ. AMP-activated protein kinase: nature's energy sensor. Nature Chemical Biology. 7: 512-8. PMID 21769098 DOI: 10.1038/Nchembio.610 |
0.531 |
|
| 2011 |
Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, et al. Structure of mammalian AMPK and its regulation by ADP. Nature. 472: 230-3. PMID 21399626 DOI: 10.1038/Nature09932 |
0.53 |
|
| 2011 |
Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, ... ... Carling D, et al. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes. 60: 735-45. PMID 21266325 DOI: 10.2337/Db10-1055 |
0.38 |
|
| 2011 |
Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. The Biochemical Journal. 434: 503-12. PMID 21204788 DOI: 10.1042/Bj20101485 |
0.757 |
|
| 2011 |
Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, Ashworth A, Withers DJ, Carling D. LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. The Biochemical Journal. 434: 49-60. PMID 21118154 DOI: 10.1042/Bj20101721 |
0.305 |
|
| 2010 |
López M, Varela L, Vázquez MJ, RodrÃguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, MartÃnez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine. 16: 1001-8. PMID 20802499 DOI: 10.1038/Nm.2207 |
0.389 |
|
| 2010 |
Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (New York, N.Y.). 329: 1201-5. PMID 20647423 DOI: 10.1126/Science.1191241 |
0.519 |
|
| 2010 |
Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML. Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. The Biochemical Journal. 429: 323-33. PMID 20465544 DOI: 10.1042/Bj20100231 |
0.38 |
|
| 2010 |
Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, Viollet B, Carling D, Heller R. Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. The Journal of Biological Chemistry. 285: 10638-52. PMID 20129920 DOI: 10.1074/Jbc.M110.108688 |
0.438 |
|
| 2010 |
Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. The Embo Journal. 29: 376-86. PMID 19927127 DOI: 10.1038/Emboj.2009.342 |
0.456 |
|
| 2010 |
GarcÃa-GarcÃa C, Fumarola C, Navaratnam N, Carling D, López-Rivas A. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochemical Pharmacology. 79: 853-63. PMID 19896469 DOI: 10.1016/J.Bcp.2009.10.022 |
0.417 |
|
| 2009 |
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, ... ... Carling D, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (New York, N.Y.). 326: 140-4. PMID 19797661 DOI: 10.1126/Science.1177221 |
0.447 |
|
| 2009 |
Renz B, Davies JK, Carling D, Watkins H, Redwood C. Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: a cautionary tale. Protein Expression and Purification. 66: 181-4. PMID 19269329 DOI: 10.1016/J.Pep.2009.02.016 |
0.532 |
|
| 2009 |
Bright NJ, Thornton C, Carling D. The regulation and function of mammalian AMPK-related kinases. Acta Physiologica (Oxford, England). 196: 15-26. PMID 19245655 DOI: 10.1111/J.1748-1716.2009.01971.X |
0.757 |
|
| 2009 |
Carling D. Branching out on AMPK Regulation. Cell Metabolism. 9: 7-8. PMID 19117541 DOI: 10.1016/J.Cmet.2008.12.007 |
0.46 |
|
| 2009 |
Denison FC, Hiscock NJ, Carling D, Woods A. Characterization of an alternative splice variant of LKB1. The Journal of Biological Chemistry. 284: 67-76. PMID 18854309 DOI: 10.1074/Jbc.M806153200 |
0.544 |
|
| 2008 |
Sag D, Carling D, Stout RD, Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. Journal of Immunology (Baltimore, Md. : 1950). 181: 8633-41. PMID 19050283 DOI: 10.4049/Jimmunol.181.12.8633 |
0.366 |
|
| 2008 |
Carling D, Sanders MJ, Woods A. The regulation of AMP-activated protein kinase by upstream kinases. International Journal of Obesity (2005). 32: S55-9. PMID 18719600 DOI: 10.1038/Ijo.2008.124 |
0.611 |
|
| 2008 |
López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, RodrÃguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, ... ... Carling D, et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metabolism. 7: 389-99. PMID 18460330 DOI: 10.1016/J.Cmet.2008.03.006 |
0.391 |
|
| 2008 |
Thornton C, Sardini A, Carling D. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. The Journal of Biological Chemistry. 283: 17116-22. PMID 18436530 DOI: 10.1074/Jbc.M708987200 |
0.66 |
|
| 2008 |
Bright NJ, Carling D, Thornton C. Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. The Journal of Biological Chemistry. 283: 14946-54. PMID 18339622 DOI: 10.1074/Jbc.M710381200 |
0.774 |
|
| 2007 |
Carling D. The role of the AMP-activated protein kinase in the regulation of energy homeostasis. Novartis Foundation Symposium. 286: 72-81; discussion 81. PMID 18269175 DOI: 10.1002/9780470985571.Ch7 |
0.595 |
|
| 2007 |
Dranchak PK, Leiper FC, Valberg SJ, Piercy RJ, Carling D, McCue ME, Mickelson JR. Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses. American Journal of Veterinary Research. 68: 1079-84. PMID 17916014 DOI: 10.2460/Ajvr.68.10.1079 |
0.398 |
|
| 2007 |
Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong YC, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, Combs TP. Low utilization of circulating glucose after food withdrawal in Snell dwarf mice. The Journal of Biological Chemistry. 282: 35069-77. PMID 17905742 DOI: 10.1074/Jbc.M700484200 |
0.341 |
|
| 2007 |
Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, Gamblin SJ. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature. 449: 496-500. PMID 17851531 DOI: 10.1038/Nature06161 |
0.489 |
|
| 2007 |
Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling D. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. The Journal of Biological Chemistry. 282: 32539-48. PMID 17728241 DOI: 10.1074/Jbc.M706543200 |
0.531 |
|
| 2007 |
Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, ... Carling D, et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. The Journal of Clinical Investigation. 117: 2325-36. PMID 17671657 DOI: 10.1172/Jci31516 |
0.366 |
|
| 2007 |
Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, Miraux S, Thiaudière E, Foretz M, Viollet B, Diolez P, Bastin J, Benit P, Rustin P, Carling D, et al. S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metabolism. 5: 476-87. PMID 17550782 DOI: 10.1016/J.Cmet.2007.05.006 |
0.492 |
|
| 2007 |
Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz P. A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits. The Journal of Biological Chemistry. 282: 16117-25. PMID 17403675 DOI: 10.1074/Jbc.M611804200 |
0.373 |
|
| 2007 |
Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes. 56: 1387-94. PMID 17287464 DOI: 10.2337/Db06-1580 |
0.384 |
|
| 2007 |
Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, et al. Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron. 53: 233-47. PMID 17224405 DOI: 10.1016/J.Neuron.2006.12.015 |
0.391 |
|
| 2007 |
Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. The Biochemical Journal. 403: 139-48. PMID 17147517 DOI: 10.1042/Bj20061520 |
0.593 |
|
| 2007 |
Carling D. AMP‐activated protein kinase and the regulation of energy metabolism The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A206-D |
0.486 |
|
| 2006 |
Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism. 4: 465-74. PMID 17141630 DOI: 10.1016/J.Cmet.2006.11.005 |
0.372 |
|
| 2006 |
Stahmann N, Woods A, Carling D, Heller R. Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. Molecular and Cellular Biology. 26: 5933-45. PMID 16880506 DOI: 10.1128/Mcb.00383-06 |
0.57 |
|
| 2006 |
Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. American Journal of Physiology. Heart and Circulatory Physiology. 291: H1927-34. PMID 16648175 DOI: 10.1152/Ajpheart.00251.2006 |
0.402 |
|
| 2006 |
Carling D. LKB1: a sweet side to Peutz-Jeghers syndrome? Trends in Molecular Medicine. 12: 144-7. PMID 16530014 DOI: 10.1016/J.Molmed.2006.02.003 |
0.425 |
|
| 2006 |
Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, Rider MH. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. The Journal of Biological Chemistry. 281: 5335-40. PMID 16340011 DOI: 10.1074/Jbc.M506850200 |
0.567 |
|
| 2006 |
Davies JK, Wells DJ, Liu K, Whitrow HR, Daniel TD, Grignani R, Lygate CA, Schneider JE, Noël G, Watkins H, Carling D. Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1942-51. PMID 16339829 DOI: 10.1152/Ajpheart.01020.2005 |
0.459 |
|
| 2005 |
Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metabolism. 2: 21-33. PMID 16054096 DOI: 10.1016/J.Cmet.2005.06.005 |
0.591 |
|
| 2005 |
Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism. 1: 15-25. PMID 16054041 DOI: 10.1016/J.Cmet.2004.12.003 |
0.471 |
|
| 2005 |
Fryer LG, Carling D. AMP-activated protein kinase and the metabolic syndrome. Biochemical Society Transactions. 33: 362-6. PMID 15787607 DOI: 10.1042/Bst0330362 |
0.462 |
|
| 2005 |
Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D, Richter EA. Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity. Biochemical and Biophysical Research Communications. 329: 719-25. PMID 15737645 DOI: 10.1016/J.Bbrc.2005.02.027 |
0.388 |
|
| 2005 |
Carling D. AMP-activated protein kinase: balancing the scales. Biochimie. 87: 87-91. PMID 15733742 DOI: 10.1016/J.Biochi.2004.10.017 |
0.57 |
|
| 2005 |
Sidhu JS, Rajawat YS, Rami TG, Gollob MH, Wang Z, Yuan R, Marian AJ, DeMayo FJ, Weilbacher D, Taffet GE, Davies JK, Carling D, Khoury DS, Roberts R. Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Circulation. 111: 21-9. PMID 15611370 DOI: 10.1161/01.Cir.0000151291.32974.D5 |
0.364 |
|
| 2004 |
Small CJ, Carling D, Bloom SR. Cellular energy sensor balances the scales. Nature Medicine. 10: 681-2. PMID 15229514 DOI: 10.1038/Nm0704-681 |
0.36 |
|
| 2004 |
Clark H, Carling D, Saggerson D. Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids. European Journal of Biochemistry / Febs. 271: 2215-24. PMID 15153111 DOI: 10.1111/J.1432-1033.2004.04151.X |
0.506 |
|
| 2004 |
Carling D. AMPK. Current Biology : Cb. 14: R220. PMID 15043827 DOI: 10.1016/j.cub.2004.02.048 |
0.34 |
|
| 2004 |
Cheng SW, Fryer LG, Carling D, Shepherd PR. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. The Journal of Biological Chemistry. 279: 15719-22. PMID 14970221 DOI: 10.1074/Jbc.C300534200 |
0.559 |
|
| 2004 |
Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ. AMP-activated protein kinase plays a role in the control of food intake. The Journal of Biological Chemistry. 279: 12005-8. PMID 14742438 DOI: 10.1074/Jbc.C300557200 |
0.399 |
|
| 2004 |
Carling D. The AMP-activated protein kinase cascade--a unifying system for energy control. Trends in Biochemical Sciences. 29: 18-24. PMID 14729328 DOI: 10.1016/J.Tibs.2003.11.005 |
0.525 |
|
| 2004 |
Cantó C, Suárez E, Lizcano JM, Griñó E, Shepherd PR, Fryer LG, Carling D, Bertran J, PalacÃn M, Zorzano A, Gumà A. Neuregulin signaling on glucose transport in muscle cells. The Journal of Biological Chemistry. 279: 12260-8. PMID 14711829 DOI: 10.1074/Jbc.M308554200 |
0.38 |
|
| 2003 |
Carling D, Fryer LG, Woods A, Daniel T, Jarvie SL, Whitrow H. Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase. Biochemical Society Transactions. 31: 1157-60. PMID 14641016 DOI: 10.1042/Bst0311157 |
0.505 |
|
| 2003 |
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Current Biology : Cb. 13: 2004-8. PMID 14614828 DOI: 10.1016/J.Cub.2003.10.031 |
0.597 |
|
| 2003 |
Neumann D, Woods A, Carling D, Wallimann T, Schlattner U. Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expression and Purification. 30: 230-7. PMID 12880772 DOI: 10.1016/S1046-5928(03)00126-8 |
0.468 |
|
| 2003 |
Hong SP, Leiper FC, Woods A, Carling D, Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proceedings of the National Academy of Sciences of the United States of America. 100: 8839-43. PMID 12847291 DOI: 10.1073/Pnas.1533136100 |
0.594 |
|
| 2003 |
Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carling D, Rider MH. Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. The Journal of Biological Chemistry. 278: 28434-42. PMID 12764152 DOI: 10.1074/Jbc.M303946200 |
0.545 |
|
| 2003 |
Wang W, Yang X, López de Silanes I, Carling D, Gorospe M. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. The Journal of Biological Chemistry. 278: 27016-23. PMID 12730239 DOI: 10.1074/Jbc.M300318200 |
0.497 |
|
| 2003 |
Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochemical Society Transactions. 31: 202-6. PMID 12546685 DOI: 10.1042/Bst0310202 |
0.471 |
|
| 2003 |
Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. The Journal of Clinical Investigation. 111: 91-8. PMID 12511592 DOI: 10.1172/Jci16567 |
0.394 |
|
| 2003 |
Halse R, Fryer LG, McCormack JG, Carling D, Yeaman SJ. Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase. Diabetes. 52: 9-15. PMID 12502487 DOI: 10.2337/Diabetes.52.1.9 |
0.462 |
|
| 2003 |
Davies JK, Carling D. Transgenic mice over-expressing the γ2 subunit of AMP-activated protein kinase: a model of hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome Journal of Cardiac Failure. 9: S7. DOI: 10.1016/S1071-9164(03)00187-8 |
0.447 |
|
| 2002 |
Brandão RL, Etchebehere L, Queiroz CC, Trópia MJ, Ernandes JR, Gonçalves T, Loureiro-Dias MC, Winderickx J, Thevelein JM, Leiper FC, Carling D, Castro IM. Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2. Fems Yeast Research. 2: 93-102. PMID 12702297 DOI: 10.1111/J.1567-1364.2002.Tb00074.X |
0.459 |
|
| 2002 |
Salgado AP, Schuller D, Casal M, Leão C, Leiper FC, Carling D, Fietto LG, Trópia MJ, Castro IM, Brandão RL. Relationship between protein kinase C and derepression of different enzymes. Febs Letters. 532: 324-32. PMID 12482587 DOI: 10.1016/S0014-5793(02)03695-5 |
0.482 |
|
| 2002 |
Fryer LG, Parbu-Patel A, Carling D. Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. Febs Letters. 531: 189-92. PMID 12417310 DOI: 10.1016/S0014-5793(02)03501-9 |
0.564 |
|
| 2002 |
Daniel T, Carling D. Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. The Journal of Biological Chemistry. 277: 51017-24. PMID 12397075 DOI: 10.1074/Jbc.M207093200 |
0.41 |
|
| 2002 |
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, ... Carling D, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine. 8: 1288-95. PMID 12368907 DOI: 10.1038/Nm788 |
0.464 |
|
| 2002 |
Barnes BR, Ryder JW, Steiler TL, Fryer LG, Carling D, Zierath JR. Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction. Diabetes. 51: 2703-8. PMID 12196462 DOI: 10.2337/Diabetes.51.9.2703 |
0.406 |
|
| 2002 |
Barnes K, Ingram JC, Porras OH, Barros LF, Hudson ER, Fryer LG, Foufelle F, Carling D, Hardie DG, Baldwin SA. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). Journal of Cell Science. 115: 2433-42. PMID 12006627 |
0.443 |
|
| 2002 |
Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. The Journal of Biological Chemistry. 277: 25226-32. PMID 11994296 DOI: 10.1074/Jbc.M202489200 |
0.572 |
|
| 2002 |
Wang W, Fan J, Yang X, Fürer-Galban S, Lopez de Silanes I, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe M. AMP-activated kinase regulates cytoplasmic HuR. Molecular and Cellular Biology. 22: 3425-36. PMID 11971974 DOI: 10.1128/Mcb.22.10.3425-3436.2002 |
0.445 |
|
| 2002 |
Daniel T, Carling D. Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits. The Biochemical Journal. 365: 629-38. PMID 11971761 DOI: 10.1042/Bj20020124 |
0.576 |
|
| 2002 |
Fryer LG, Foufelle F, Barnes K, Baldwin SA, Woods A, Carling D. Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. The Biochemical Journal. 363: 167-74. PMID 11903059 DOI: 10.1042/Bj3630167 |
0.48 |
|
| 2002 |
Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 415: 339-43. PMID 11797013 DOI: 10.1038/415339A |
0.488 |
|
| 2002 |
Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 51: 159-67. PMID 11756336 DOI: 10.2337/Diabetes.51.1.159 |
0.456 |
|
| 2001 |
Marsin A, Bertrand L, Beauloye C, Rider MH, Carling D, Hue L. Phosphorylation and activation of heart PFK-2 by AMPK plays a role in the stimulation of glycolysis during ischemia Journal of Molecular and Cellular Cardiology. 33. DOI: 10.1016/S0022-2828(01)90656-X |
0.447 |
|
| 2001 |
Jarvie S, Bayliss J, Carling D. Investigation of AMP-activated protein kinase gamma subunit isoforms Journal of Molecular and Cellular Cardiology. 33: A170. DOI: 10.1016/S0022-2828(01)90653-4 |
0.546 |
|
| 2001 |
Carling D. Studies on AMP-activated protein kinase using a mouse muscle cell line Journal of Molecular and Cellular Cardiology. 33: A146. DOI: 10.1016/S0022-2828(01)90560-7 |
0.471 |
|
| 2000 |
Fryer LG, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, Carling D. Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes. 49: 1978-85. PMID 11117997 DOI: 10.2337/Diabetes.49.12.1978 |
0.421 |
|
| 2000 |
Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue L. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Current Biology : Cb. 10: 1247-55. PMID 11069105 DOI: 10.1016/S0960-9822(00)00742-9 |
0.553 |
|
| 2000 |
Woods A, Azzout-Marniche D, Foretz M, Stein SC, Lemarchand P, Ferré P, Foufelle F, Carling D. Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Molecular and Cellular Biology. 20: 6704-11. PMID 10958668 DOI: 10.1128/Mcb.20.18.6704-6711.2000 |
0.485 |
|
| 2000 |
Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. The Biochemical Journal. 346: 659-69. PMID 10698692 DOI: 10.1042/Bj3460659 |
0.433 |
|
| 2000 |
Stein SC, Woods A, Jones NA, Davison MD, Carling D. The regulation of AMP-activated protein kinase by phosphorylation. The Biochemical Journal. 345: 437-43. PMID 10642499 DOI: 10.1042/Bj3450437 |
0.57 |
|
| 1999 |
Blázquez C, Woods A, de Ceballos ML, Carling D, Guzmán M. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. Journal of Neurochemistry. 73: 1674-82. PMID 10501215 DOI: 10.1046/J.1471-4159.1999.731674.X |
0.459 |
|
| 1999 |
Smith FC, Davies SP, Wilson WA, Carling D, Hardie DG. The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. Febs Letters. 453: 219-23. PMID 10403407 DOI: 10.1016/S0014-5793(99)00725-5 |
0.523 |
|
| 1998 |
Velasco G, Gómez del Pulgar T, Carling D, Guzmán M. Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. Febs Letters. 439: 317-20. PMID 9845345 DOI: 10.1016/S0014-5793(98)01400-8 |
0.532 |
|
| 1998 |
Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annual Review of Biochemistry. 67: 821-55. PMID 9759505 DOI: 10.1146/Annurev.Biochem.67.1.821 |
0.569 |
|
| 1998 |
Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. The Biochemical Journal. 334: 177-87. PMID 9693118 DOI: 10.1042/Bj3340177 |
0.424 |
|
| 1998 |
Foretz M, Carling D, Guichard C, Ferré P, Foufelle F. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. The Journal of Biological Chemistry. 273: 14767-71. PMID 9614076 DOI: 10.1074/Jbc.273.24.14767 |
0.508 |
|
| 1998 |
Thornton C, Snowden MA, Carling D. Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. The Journal of Biological Chemistry. 273: 12443-50. PMID 9575201 DOI: 10.1074/Jbc.273.20.12443 |
0.556 |
|
| 1998 |
Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. The Embo Journal. 17: 1688-99. PMID 9501090 DOI: 10.1093/Emboj/17.6.1688 |
0.537 |
|
| 1997 |
Cheung PC, Carling D. Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues. Biochemical Society Transactions. 25: S668. PMID 9450096 DOI: 10.1042/Bst025S668 |
0.572 |
|
| 1997 |
Thornton C, Snowden MA, Carling D. Identification of a novel AMPK beta subunit that is highly expressed in skeletal muscle. Biochemical Society Transactions. 25: S667. PMID 9450095 DOI: 10.1042/Bst025S667 |
0.481 |
|
| 1997 |
Carling D, Woods A, Thornton C, Cheung PC, Smith FC, Ponticos M, Stein SC. Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism. Biochemical Society Transactions. 25: 1224-8. PMID 9449980 DOI: 10.1042/Bst0251224 |
0.653 |
|
| 1997 |
Hardie DG, Carling D. The AMP-activated protein kinase--fuel gauge of the mammalian cell? European Journal of Biochemistry / Febs. 246: 259-73. PMID 9208914 DOI: 10.1111/J.1432-1033.1997.00259.X |
0.595 |
|
| 1997 |
Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW. Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase. Febs Letters. 403: 254-8. PMID 9091312 DOI: 10.1016/S0014-5793(97)00062-8 |
0.557 |
|
| 1997 |
Cfcheung P, Carling D. 140 Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues Biochemical Society Transactions. 25: S669. |
0.401 |
|
| 1997 |
Thornton C, Snowden MA, Carling D. 139 identification of a novel ampkβ subunit that is highly expressed in skeletal muscle Biochemical Society Transactions. 25: S668. |
0.408 |
|
| 1996 |
Marley AE, Sullivan JE, Carling D, Abbott WM, Smith GJ, Taylor IW, Carey F, Beri RK. Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha. The Biochemical Journal. 320: 801-6. PMID 9003365 DOI: 10.1042/Bj3200801 |
0.445 |
|
| 1996 |
Woods A, Salt I, Scott J, Hardie DG, Carling D. The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. Febs Letters. 397: 347-51. PMID 8955377 DOI: 10.1016/S0014-5793(96)01209-4 |
0.357 |
|
| 1996 |
Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. The Journal of Biological Chemistry. 271: 27879-87. PMID 8910387 DOI: 10.1074/Jbc.271.44.27879 |
0.572 |
|
| 1996 |
Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK, Carling D. Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. The Journal of Biological Chemistry. 271: 10282-90. PMID 8626596 DOI: 10.1074/Jbc.271.17.10282 |
0.511 |
|
| 1995 |
Verhoeven AJ, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D. The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. European Journal of Biochemistry / Febs. 228: 236-43. PMID 7705334 DOI: 10.1111/J.1432-1033.1995.Tb20255.X |
0.417 |
|
| 1995 |
Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. The Journal of Biological Chemistry. 270: 27186-91. PMID 7592975 DOI: 10.1074/Jbc.270.45.27186 |
0.547 |
|
| 1995 |
Verhoeven AJM, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D. The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle Febs Journal. 228: 236-243. DOI: 10.1111/J.1432-1033.1995.0236N.X |
0.416 |
|
| 1994 |
Sullivan JE, Carey F, Carling D, Beri RK. Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity. Biochemical and Biophysical Research Communications. 200: 1551-6. PMID 8185610 DOI: 10.1006/Bbrc.1994.1627 |
0.366 |
|
| 1994 |
Davies SP, Hawley SA, Woods A, Carling D, Haystead TA, Hardie DG. Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. European Journal of Biochemistry / Febs. 223: 351-7. PMID 8055903 DOI: 10.1111/J.1432-1033.1994.Tb19001.X |
0.475 |
|
| 1994 |
Beri RK, Marley AE, See CG, Sopwith WF, Aguan K, Carling D, Scott J, Carey F. Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. Febs Letters. 356: 117-21. PMID 7988703 DOI: 10.1016/0014-5793(94)01247-4 |
0.347 |
|
| 1994 |
Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. Febs Letters. 353: 33-6. PMID 7926017 DOI: 10.1016/0014-5793(94)01006-4 |
0.568 |
|
| 1994 |
Woods A, Munday MR, Scott J, Yang X, Carlson M, Carling D. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. The Journal of Biological Chemistry. 269: 19509-15. PMID 7913470 |
0.46 |
|
| 1994 |
Carling D, Aguan K, Woods A, Verhoeven AJ, Beri RK, Brennan CH, Sidebottom C, Davison MD, Scott J. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. The Journal of Biological Chemistry. 269: 11442-8. PMID 7908907 |
0.467 |
|
| 1994 |
Hardie DG, Carling D, Halford N. Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. Seminars in Cell Biology. 5: 409-16. PMID 7711289 DOI: 10.1006/Scel.1994.1048 |
0.418 |
|
| 1994 |
Sullivan J, Brocklehurst K, Marley A, Carey F, Carling D, Beri R. Characterization of 5′-AMP activated protein kinase in human liver using specific peptide substrates and the effects of 5′-AMP analogues on enzyme activity in vitro and in primary rat adipocytes Atherosclerosis. 109: 119. DOI: 10.1016/0021-9150(94)93488-6 |
0.445 |
|
| 1994 |
Beri R, Marley A, Sopwith W, Aguan K, Carling D, Scott J, Carey F. Human AMP-activated protein kinase: cloning, expression and chromosomal localization Atherosclerosis. 109: 104. DOI: 10.1016/0021-9150(94)93428-2 |
0.44 |
|
| 1992 |
Davies SP, Carling D, Munday MR, Hardie DG. Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. European Journal of Biochemistry / Febs. 203: 615-23. PMID 1346520 DOI: 10.1111/J.1432-1033.1992.Tb16591.X |
0.567 |
|
| 1991 |
Carling D, Clarke PR, Hardie DG. Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase. Methods in Enzymology. 200: 362-71. PMID 1683469 DOI: 10.1016/0076-6879(91)00153-N |
0.483 |
|
| 1989 |
Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. European Journal of Biochemistry / Febs. 186: 129-36. PMID 2598924 DOI: 10.1111/J.1432-1033.1989.Tb15186.X |
0.557 |
|
| 1989 |
Davies SP, Carling D, Hardie DG. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. European Journal of Biochemistry / Febs. 186: 123-8. PMID 2574667 DOI: 10.1111/J.1432-1033.1989.Tb15185.X |
0.526 |
|
| 1989 |
Carling D, Hardie DG. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochimica Et Biophysica Acta. 1012: 81-6. PMID 2567185 DOI: 10.1016/0167-4889(89)90014-1 |
0.475 |
|
| 1989 |
Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337: 78-81. PMID 2562908 DOI: 10.1038/337078A0 |
0.491 |
|
| 1989 |
Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. European Journal of Biochemistry / Febs. 179: 249-54. PMID 2537200 DOI: 10.1111/J.1432-1033.1989.Tb14548.X |
0.534 |
|
| 1989 |
Grahame Hardie D, Carling D, T.R. Sim A. The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism Trends in Biochemical Sciences. 14: 20-23. DOI: 10.1016/0968-0004(89)90084-4 |
0.506 |
|
| 1988 |
Munday MR, Carling D, Hardie DG. Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. Febs Letters. 235: 144-8. PMID 2900158 DOI: 10.1016/0014-5793(88)81251-1 |
0.518 |
|
| 1988 |
Munday MR, Campbell DG, Carling D, Hardie DG. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. European Journal of Biochemistry / Febs. 175: 331-8. PMID 2900138 DOI: 10.1111/J.1432-1033.1988.Tb14201.X |
0.535 |
|
| 1987 |
Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. Febs Letters. 223: 217-22. PMID 2889619 DOI: 10.1016/0014-5793(87)80292-2 |
0.53 |
|
| 1986 |
Hardie DG, Carling D, Ferrari S, Guy PS, Aitken A. Characterization of the phosphorylation of rat mammary ATP-citrate lyase and acetyl-CoA carboxylase by Ca2+ and calmodulin-dependent multiprotein kinase and Ca2+ and phospholipid-dependent protein kinase. European Journal of Biochemistry / Febs. 157: 553-61. PMID 2873035 DOI: 10.1111/J.1432-1033.1986.Tb09702.X |
0.542 |
|
| 1986 |
Carling D, Hardie DG. Isolation of a cyclic-AMP-independent protein kinase from rat liver and its effect on the enzymic activity of acetyl-CoA carboxylase Biochemical Society Transactions. 14: 1076-1077. DOI: 10.1042/Bst0141076 |
0.444 |
|
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