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Frank T. Horrigan - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
biophysics
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sun L, Horrigan FT. A gating lever and molecular logic gate that couple voltage and calcium sensor activation to opening in BK potassium channels. Science Advances. 8: eabq5772. PMID 36516264 DOI: 10.1126/sciadv.abq5772  0.465
2019 Kim MD, Baumlin N, Yoshida M, Polineni D, Salathe SF, David JK, Peloquin CA, Wanner A, Dennis JS, Sailland J, Whitney P, Horrigan FT, Sabater JR, Abraham WM, Salathe M. Losartan Rescues Inflammation-Related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine. PMID 31613648 DOI: 10.1164/rccm.201905-0990OC  0.355
2019 Sun L, Ann Gonzalez L, Horrigan FT. Nobiletin Inhibition of BK Channels Biophysical Journal. 116: 104a. DOI: 10.1016/j.bpj.2018.11.595  0.429
2019 Horrigan FT, Gonzalez LA, Sun L, Bloch M, Zou S. A Novel High-Throughput Screening Assay for State-Dependent and Subunit-Dependent BK Channel Modulators Biophysical Journal. 116: 248a. DOI: 10.1016/j.bpj.2018.11.1355  0.323
2016 Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death & Disease. 7: e2426. PMID 27763639 DOI: 10.1038/Cddis.2016.324  0.31
2013 Sun L, Adhikari S, Zou S, Horrigan FT. Interaction Sites between Voltage-Sensor and Gate in BK Channels Biophysical Journal. 104: 463a. DOI: 10.1016/j.bpj.2012.11.2561  0.435
2013 Gonzalez LA, Ma Z, Horrigan FT. Potential Sites of Action for Phloretin on BK Channels Biophysical Journal. 104: 463a. DOI: 10.1016/j.bpj.2012.11.2560  0.391
2012 Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. The Journal of General Physiology. 140: 625-34. PMID 23183698 DOI: 10.1085/jgp.201210849  0.542
2012 Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. The Journal of Biological Chemistry. 287: 4014-22. PMID 22074915 DOI: 10.1074/Jbc.M111.312264  0.337
2012 Sun L, Adhikari S, Zou S, Horrigan FT. The Interaction of Voltage-Sensor and Gate in BK Channels Biophysical Journal. 102: 684a. DOI: 10.1016/J.BPJ.2011.11.3717  0.452
2012 Gonzalez LA, Ma Z, Horrigan FT. The BK Channel Opener Phloretin Influences Voltage- and Calcium-Dependent Gating Biophysical Journal. 102: 683a-684a. DOI: 10.1016/j.bpj.2011.11.3716  0.449
2009 Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin, Tex.). 3: 249-58. PMID 19617704 DOI: 10.4161/chan.3.4.9253  0.732
2009 Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. The Journal of Biological Chemistry. 284: 23353-63. PMID 19561088 DOI: 10.1074/jbc.M109.027789  0.508
2009 Horrigan FT, Hoshi T. Erratum: Corrigendum: Integration of an electric-metal sensory experience in the Slo1 BK channel Nature Structural & Molecular Biology. 16: 572-572. DOI: 10.1038/nsmb0509-572b  0.484
2009 Hou S, Horrigan FT, Heinemann SH, Hoshi T. Comparative Mechanisms Of Activation Of The Slo1 BK Channel By Ca2+ And H+ Mediated By The RCK1 Domain Biophysical Journal. 96: 473a-474a. DOI: 10.1016/j.bpj.2008.12.2451  0.709
2009 Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+-and voltage-gated slo1 K+ channels Channels. 3.  0.705
2008 Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nature Structural & Molecular Biology. 15: 1130-2. PMID 18985066 DOI: 10.1038/nsmb1108-1130  0.591
2008 Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. The Journal of General Physiology. 131: 483-502. PMID 18443360 DOI: 10.1085/jgp.200809980  0.324
2008 Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. The Journal of General Physiology. 131: 13-32. PMID 18166624 DOI: 10.1085/jgp.200709877  0.489
2007 Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proceedings of the National Academy of Sciences of the United States of America. 104: 18270-5. PMID 17984060 DOI: 10.1073/pnas.0705873104  0.664
2006 Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Accounts of Chemical Research. 39: 918-24. PMID 17176030 DOI: 10.1021/ar040020w  0.565
2006 Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. The Journal of General Physiology. 127: 309-28. PMID 16505150 DOI: 10.1085/jgp.200509421  0.518
2005 Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. The Journal of General Physiology. 126: 7-21. PMID 15955873 DOI: 10.1085/jgp.200509262  0.73
2005 Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. The Journal of General Physiology. 125: 213-36. PMID 15684095 DOI: 10.1085/jgp.200409149  0.547
2003 Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 100: 10488-93. PMID 12925732 DOI: 10.1073/pnas.1834300100  0.66
2002 Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. The Journal of General Physiology. 120: 267-305. PMID 12198087 DOI: 10.1085/jgp.20028605  0.697
2002 Horrigan FT, Aldrich RW. Erratum: (Journal of General Physiology (September 2002) 120:3 (267-305)) The Journal of General Physiology. 120. DOI: 10.1085/Jgp.20020919120267  0.48
1999 Horrigan FT, Aldrich RW. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). The Journal of General Physiology. 114: 305-36. PMID 10436004 DOI: 10.1085/jgp.114.2.305  0.721
1999 Horrigan FT, Cui J, Aldrich RW. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). The Journal of General Physiology. 114: 277-304. PMID 10436003 DOI: 10.1085/jgp.114.2.277  0.735
1996 Horrigan FT, Gilly WF. Methadone block of K+ current in squid giant fiber lobe neurons. The Journal of General Physiology. 107: 243-60. PMID 8833344 DOI: 10.1085/jgp.107.2.243  0.658
1994 Horrigan FT, Bookman RJ. Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron. 13: 1119-29. PMID 7946349 DOI: 10.1016/0896-6273(94)90050-7  0.681
1990 Gilly WF, Lucero MT, Horrigan FT. Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid. Neuron. 5: 663-74. PMID 2171590 DOI: 10.1016/0896-6273(90)90220-A  0.699
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