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Ohannes K. Melemedjian, Ph.D. - Publications

Affiliations: 
Pharmacology University of Arizona, Tucson, AZ 
Area:
Pain Neuroscience
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32/41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Haque MM, Kuppusamy P, Melemedjian OK. Disruption of mitochondrial pyruvate oxidation in dorsal root ganglia drives persistent nociceptive sensitization and causes pervasive transcriptomic alterations. Pain. PMID 38285538 DOI: 10.1097/j.pain.0000000000003158  0.321
2023 Da Silva JT, Hernandez-Rojas LG, Mekonen HK, Hanson S, Melemedjian O, Scott AJ, Ernst RK, Seminowicz DA, Traub RJ. Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study. Pain. PMID 37756658 DOI: 10.1097/j.pain.0000000000003074  0.416
2019 Ludman T, Melemedjian OK. Bortezomib and metformin opposingly regulate the expression of hypoxia-inducible factor alpha and the consequent development of chemotherapy-induced painful peripheral neuropathy. Molecular Pain. 15: 1744806919850043. PMID 31041875 DOI: 10.1177/1744806919850043  0.356
2019 Ludman T, Melemedjian OK. Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy. Molecular Pain. 15: 1744806919837429. PMID 30810076 DOI: 10.1177/1744806919837429  0.37
2017 Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, et al. The MNK - eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28674170 DOI: 10.1523/Jneurosci.0220-17.2017  0.823
2015 François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 156: 1247-64. PMID 25782368 DOI: 10.1097/j.pain.0000000000000147  0.543
2015 Melemedjian OK, Khoutorsky A. Translational control of chronic pain. Progress in Molecular Biology and Translational Science. 131: 185-213. PMID 25744674 DOI: 10.1016/bs.pmbts.2014.11.006  0.474
2015 Wei X, Yan J, Tillu D, Asiedu M, Weinstein N, Melemedjian O, Price T, Dussor G. Meningeal norepinephrine produces headache behaviors in rats via actions both on dural afferents and fibroblasts. Cephalalgia : An International Journal of Headache. PMID 25601915 DOI: 10.1177/0333102414566861  0.782
2014 Melemedjian OK, Tillu DV, Moy JK, Asiedu MN, Mandell EK, Ghosh S, Dussor G, Price TJ. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Molecular Pain. 10: 45. PMID 24993495 DOI: 10.1186/1744-8069-10-45  0.787
2014 Melemedjian OK, Mejia GL, Lepow TS, Zoph OK, Price TJ. Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons. Neuroscience Letters. 563: 169-74. PMID 24080374 DOI: 10.1016/j.neulet.2013.09.048  0.626
2014 Melemedjian O, Price T. (278) Mechanisms of dysfunctional mitochondria evoked pain The Journal of Pain. 15: S45. DOI: 10.1016/J.JPAIN.2014.01.187  0.397
2014 Price T, Mejia G, Melemedjian O. (270) AMPK-mediated control of P bodies as a novel mechanism of gene expression control in peripheral sensory neurons The Journal of Pain. 15: S43. DOI: 10.1016/j.jpain.2014.01.179  0.59
2013 Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 154: 1080-91. PMID 23607966 DOI: 10.1016/J.Pain.2013.03.021  0.837
2013 Melemedjian OK, Yassine HN, Shy A, Price TJ. Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment. Molecular Pain. 9: 14. PMID 23531341 DOI: 10.1186/1744-8069-9-14  0.775
2013 Melemedjian OK, Tillu DV, Asiedu MN, Mandell EK, Moy JK, Blute VM, Taylor CJ, Ghosh S, Price TJ. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Molecular Pain. 9: 12. PMID 23510079 DOI: 10.1186/1744-8069-9-12  0.808
2012 King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain. 153: 1263-73. PMID 22482911 DOI: 10.1016/J.Pain.2012.03.006  0.828
2012 Yan J, Melemedjian OK, Price TJ, Dussor G. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6). Molecular Pain. 8: 6. PMID 22273495 DOI: 10.1186/1744-8069-8-6  0.718
2012 Tillu DV, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ. Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain. Molecular Pain. 8: 5. PMID 22269797 DOI: 10.1186/1744-8069-8-5  0.833
2012 Melemedjian OK, Price TJ. Dendritic spine plasticity as an underlying mechanism of neuropathic pain: commentary on Tan et al. Experimental Neurology. 233: 740-4. PMID 22119623 DOI: 10.1016/j.expneurol.2011.11.016  0.649
2012 Price TJ, Melemedjian OK. Fragile X mental retardation protein (FMRP) and the spinal sensory system. Results and Problems in Cell Differentiation. 54: 41-59. PMID 22009347 DOI: 10.1007/978-3-642-21649-7_4  0.69
2011 Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, Sonenberg N, Dussor G, Price TJ. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Molecular Pain. 7: 70. PMID 21936900 DOI: 10.1186/1744-8069-7-70  0.821
2011 Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Sanoja R, Bodell B, Ghosh S, Porreca F, Price TJ. Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6646-53. PMID 21543593 DOI: 10.1523/Jneurosci.6286-10.2011  0.779
2011 Tillu D, Asiedu M, Melemedjian O, Shy A, Bodell B, Sanoja R, Porreca F, Price T. Latent nociceptive sensitization requires the maintenance mechanism of LTP The Journal of Pain. 12: P33. DOI: 10.1016/J.Jpain.2011.02.133  0.72
2011 Melemedjian O, Tillu D, Asiedu M, Sanoja R, Johnson J, Peebles K, Yan J, Dussor G, Price T. Dysregulation of protein translation in neuropathic pain is resolved by AMP Kinase activators The Journal of Pain. 12: P32. DOI: 10.1016/J.Jpain.2011.02.128  0.819
2010 Melemedjian OK, Asiedu MN, Tillu DV, Peebles KA, Yan J, Ertz N, Dussor GO, Price TJ. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15113-23. PMID 21068317 DOI: 10.1523/Jneurosci.3947-10.2010  0.811
2010 Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151: 257-65. PMID 20599324 DOI: 10.1016/J.Pain.2010.05.022  0.817
2010 Price T, Melemedjian O, Peebles K, Asiedu M, Ertz N. NGF and IL-6 rapidly control gene expression in DRG neurons via signaling to translation initiation factors The Journal of Pain. 11: S25. DOI: 10.1016/J.Jpain.2010.01.106  0.769
2010 Dussor G, Wei X, Yan J, Melemedjian O. Cutaneous Mrgprd-expressing nociceptors respond to extracellular nucleotides using multiple purinergic receptors The Journal of Pain. 11: S24. DOI: 10.1016/J.Jpain.2010.01.103  0.32
2009 Price T, Asiedu M, Melemedjian O. IL-6-induced nociception: role of ERK – MNK – eIF4E signaling The Journal of Pain. 10: S21. DOI: 10.1016/J.Jpain.2009.01.089  0.772
2008 Jimenez-Andrade JM, Herrera MB, Ghilardi JR, Vardanyan M, Melemedjian OK, Mantyh PW. Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Molecular Pain. 4: 10. PMID 18353190 DOI: 10.1186/1744-8069-4-10  0.705
2007 King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, Vanderah TW, Lai J, Porreca F. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132: 154-68. PMID 17706870 DOI: 10.1016/J.Pain.2007.06.026  0.744
2006 Vardanyan A, King T, Melemedjian O, Majuta L, Lai J, Porreca F. (330/631) The Journal of Pain. 7: S8. DOI: 10.1016/J.Jpain.2006.01.435  0.684
Low-probability matches (unlikely to be authored by this person)
2014 Wei X, Melemedjian OK, Ahn DD, Weinstein N, Dussor G. Dural fibroblasts play a potential role in headache pathophysiology. Pain. 155: 1238-44. PMID 24657451 DOI: 10.1016/J.Pain.2014.03.013  0.23
2016 Auh QS, Chun YH, Melemedjian OK, Zhang Y, Ro JY. Peripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia. Brain Research Bulletin. PMID 27450703 DOI: 10.1016/j.brainresbull.2016.07.009  0.211
2014 Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R. The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Frontiers in Cellular Neuroscience. 8: 196. PMID 25104922 DOI: 10.3389/Fncel.2014.00196  0.198
1999 Almawi WY, Melemedjian OK, Rieder MJ. An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile. Clinical Transplantation. 13: 365-74. PMID 10515216 DOI: 10.1034/j.1399-0012.1999.130501.x  0.188
2002 Almawi WY, Melemedjian OK. Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor. Journal of Leukocyte Biology. 71: 9-15. PMID 11781376  0.143
2004 Almawi WY, Melemedjian OK, Jaoude MM. On the link between Bcl-2 family proteins and glucocorticoid-induced apoptosis. Journal of Leukocyte Biology. 76: 7-14. PMID 15075361 DOI: 10.1189/jlb.0903450  0.138
2002 Almawi WY, Melemedjian OK. Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids. Journal of Molecular Endocrinology. 28: 69-78. PMID 11932204 DOI: 10.1677/jme.0.0280069  0.134
2013 Almawi WY, Al-Shaikh FS, Melemedjian OK, Almawi AW. Protein Z, an anticoagulant protein with expanding role in reproductive biology. Reproduction (Cambridge, England). 146: R73-80. PMID 23690629 DOI: 10.1530/REP-13-0072  0.089
2000 Almawi WY, Melemedjian OK. Clinical and mechanistic differences between FK506 (tacrolimus) and cyclosporin A. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 15: 1916-8. PMID 11096132  0.033
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