Edwin McCleskey, PhD - Publications

Affiliations: 
2002 Oregon Health and Science University, Portland, OR 
 2002- Howard Hughes Medical Institute, Chevy Chase, MD, United States 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Birdsong WT, Fierro L, Williams FG, Spelta V, Naves LA, Knowles M, Marsh-Haffner J, Adelman JP, Almers W, Elde RP, McCleskey EW. Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron. 68: 739-49. PMID 21092862 DOI: 10.1016/j.neuron.2010.09.029  1
2009 McCleskey EW. A molecular sensor for the baroreceptor reflex? Neuron. 64: 776-7. PMID 20064383 DOI: 10.1016/j.neuron.2009.12.020  1
2008 Dussor G, Zylka MJ, Anderson DJ, McCleskey EW. Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors. Journal of Neurophysiology. 99: 1581-9. PMID 18234974 DOI: 10.1152/jn.01396.2007  1
2007 McCleskey EW. Neuroscience: a local route to pain relief. Nature. 449: 545-6. PMID 17914381 DOI: 10.1038/449545a  1
2007 Cushman KA, Marsh-Haffner J, Adelman JP, McCleskey EW. A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3. The Journal of General Physiology. 129: 345-50. PMID 17389250 DOI: 10.1085/jgp.200709757  1
2007 Wenk HN, McCleskey EW. A novel mouse skeletal muscle-nerve preparation and in vitro model of ischemia. Journal of Neuroscience Methods. 159: 244-51. PMID 16959326 DOI: 10.1016/j.jneumeth.2006.07.021  1
2007 Benson CJ, McCleskey EW. ASICs function as cardiac lactic acid sensors during myocardial ischemia Molecular Sensors For Cardiovascular Homeostasis. 32-50. DOI: 10.1007/978-0-387-47530-1_2  1
2006 Yagi J, Wenk HN, Naves LA, McCleskey EW. Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Circulation Research. 99: 501-9. PMID 16873722 DOI: 10.1161/01.RES.0000238388.79295.4c  1
2005 Molliver DC, Immke DC, Fierro L, Paré M, Rice FL, McCleskey EW. ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons. Molecular Pain. 1: 35. PMID 16305749 DOI: 10.1186/1744-8069-1-35  0.32
2005 Naves LA, McCleskey EW. An acid-sensing ion channel that detects ischemic pain. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 38: 1561-9. PMID 16258623  1
2005 Connor M, Naves LA, McCleskey EW. Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat. Molecular Pain. 1: 31. PMID 16242047 DOI: 10.1186/1744-8069-1-31  1
2005 Cushman KA, McCleskey EW. Acid-Sensing Ion Channels Transduction Channels in Sensory Cells. 57-72. DOI: 10.1002/3527603913.ch3  1
2004 Zarei MM, Toro B, McCleskey EW. Purinergic synapses formed between rat sensory neurons in primary culture. Neuroscience. 126: 195-201. PMID 15145085 DOI: 10.1016/j.neuroscience.2004.03.019  1
2004 Zamponi GW, McCleskey EW. Splicing it up: a variant of the N-type calcium channel specific for pain. Neuron. 41: 3-4. PMID 14715128 DOI: 10.1016/S0896-6273(03)00846-8  1
2003 McCleskey EW. Neurobiology: new player in pain. Nature. 424: 729-30. PMID 12917663 DOI: 10.1038/424729a  1
2003 Immke DC, McCleskey EW. Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade. Neuron. 37: 75-84. PMID 12526774 DOI: 10.1016/S0896-6273(02)01130-3  1
2003 Silbert SC, Beacham DW, McCleskey EW. Quantitative single-cell differences in mu-opioid receptor mRNA distinguish myelinated and unmyelinated nociceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 34-42. PMID 12514199  1
2003 Sather WA, McCleskey EW. Permeation and selectivity in calcium channels. Annual Review of Physiology. 65: 133-59. PMID 12471162 DOI: 10.1146/annurev.physiol.65.092101.142345  1
2002 Molliver DC, Cook SP, Carlsten JA, Wright DE, McCleskey EW. ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2. The European Journal of Neuroscience. 16: 1850-60. PMID 12453048 DOI: 10.1046/j.1460-9568.2002.02253.x  1
2002 Cook SP, McCleskey EW. Cell damage excites nociceptors through release of cytosolic ATP. Pain. 95: 41-7. PMID 11790466 DOI: 10.1016/S0304-3959(01)00372-4  1
2001 Immke DC, McCleskey EW. ASIC3: a lactic acid sensor for cardiac pain. Thescientificworldjournal. 1: 510-2. PMID 12805843 DOI: 10.1100/tsw.2001.254  1
2001 Immke DC, McCleskey EW. Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nature Neuroscience. 4: 869-70. PMID 11528414 DOI: 10.1038/nn0901-869  1
2001 Sutherland SP, Benson CJ, Adelman JP, McCleskey EW. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America. 98: 711-6. PMID 11120882 DOI: 10.1073/pnas.011404498  1
2000 Sutherland SP, Cook SP, McCleskey EW. Chemical mediators of pain due to tissue damage and ischemia. Progress in Brain Research. 129: 21-38. PMID 11098679 DOI: 10.1016/S0079-6123(00)29003-1  1
2000 Cook SP, McCleskey EW. ATP, pain and a full bladder. Nature. 407: 951-2. PMID 11069162 DOI: 10.1038/35039648  1
2000 York RD, Molliver DC, Grewal SS, Stenberg PE, McCleskey EW, Stork PJ. Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Molecular and Cellular Biology. 20: 8069-83. PMID 11027277 DOI: 10.1128/MCB.20.21.8069-8083.2000  1
2000 McCleskey EW. Ion channel selectivity using an electric stew. Biophysical Journal. 79: 1691-2. PMID 11023876  1
1999 McCleskey EW. Calcium channel permeation: A field in flux. The Journal of General Physiology. 113: 765-72. PMID 10352027 DOI: 10.1085/jgp.113.6.765  1
1999 Benson CJ, Eckert SP, McCleskey EW. Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation. Circulation Research. 84: 921-8. PMID 10222339  1
1999 McCleskey EW, Gold MS. Ion channels of nociception. Annual Review of Physiology. 61: 835-56. PMID 10099712 DOI: 10.1146/annurev.physiol.61.1.835  1
1998 Cook SP, Rodland KD, McCleskey EW. A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9238-44. PMID 9801363  1
1998 Mogil JS, Shin YH, McCleskey EW, Kim SC, Nah SY. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice. Brain Research. 792: 218-28. PMID 9593902 DOI: 10.1016/S0006-8993(98)00133-4  1
1998 York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJ. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature. 392: 622-6. PMID 9560161 DOI: 10.1038/33451  1
1998 Dang TX, McCleskey EW. Ion channel selectivity through stepwise changes in binding affinity. The Journal of General Physiology. 111: 185-93. PMID 9450938 DOI: 10.1085/jgp.111.2.181  1
1997 Eckert SP, Taddese A, McCleskey EW. Isolation and culture of rat sensory neurons having distinct sensory modalities. Journal of Neuroscience Methods. 77: 183-90. PMID 9489896 DOI: 10.1016/S0165-0270(97)00125-8  1
1997 McCleskey EW. Thermoreceptors: recent heat in thermosensation. Current Biology : Cb. 7: R679-81. PMID 9382796  1
1997 Cook SP, McCleskey EW. Desensitization, recovery and Ca(2+)-dependent modulation of ATP-gated P2X receptors in nociceptors. Neuropharmacology. 36: 1303-8. PMID 9364485 DOI: 10.1016/S0028-3908(97)00132-9  1
1997 Ingram S, Wilding TJ, McCleskey EW, Williams JT. Efficacy and kinetics of opioid action on acutely dissociated neurons. Molecular Pharmacology. 52: 136-43. PMID 9224823  1
1997 McCleskey EW. Biophysics of a trespasser, Na+ block of Ca2+ channels. The Journal of General Physiology. 109: 677-80. PMID 9222894 DOI: 10.1085/jgp.109.6.677  1
1997 Cook SP, Vulchanova L, Hargreaves KM, Elde R, McCleskey EW. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature. 387: 505-8. PMID 9168113 DOI: 10.1038/387505a0  1
1996 Desai SA, McCleskey EW, Schlesinger PH, Krogstad DJ. A novel pathway for Ca++ entry into Plasmodium falciparum-infected blood cells. The American Journal of Tropical Medicine and Hygiene. 54: 464-70. PMID 8644899  1
1995 Womack MD, McCleskey EW. Interaction of opioids and membrane potential to modulate Ca2+ channels in rat dorsal root ganglion neurons. Journal of Neurophysiology. 73: 1793-8. PMID 7623080  1
1995 Nah SY, Park HJ, McCleskey EW. A trace component of ginseng that inhibits Ca2+ channels through a pertussis toxin-sensitive G protein. Proceedings of the National Academy of Sciences of the United States of America. 92: 8739-43. PMID 7568008  1
1995 Wilding TJ, Womack MD, McCleskey EW. Fast, local signal transduction between the mu opioid receptor and Ca2+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 4124-32. PMID 7538571  1
1995 Taddese A, Nah SY, McCleskey EW. Selective opioid inhibition of small nociceptive neurons. Science (New York, N.Y.). 270: 1366-9. PMID 7481826  1
1994 Nah SY, McCleskey EW. Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as mu-type opioids. Journal of Ethnopharmacology. 42: 45-51. PMID 8046943 DOI: 10.1016/0378-8741(94)90022-1  1
1994 McCleskey EW. Calcium channels: cellular roles and molecular mechanisms. Current Opinion in Neurobiology. 4: 304-12. PMID 7919927 DOI: 10.1016/0959-4388(94)90090-6  1
1993 McCleskey EW, Womack MD, Fieber LA. Structural properties of voltage-dependent calcium channels. International Review of Cytology. 137: 39-54. PMID 8387471  1
1993 Akins PT, McCleskey EW. Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP. Neuroscience. 56: 759-69. PMID 8255432 DOI: 10.1016/0306-4522(93)90372-M  1
1993 Desai SA, Krogstad DJ, McCleskey EW. A nutrient-permeable channel on the intraerythrocytic malaria parasite. Nature. 362: 643-6. PMID 7681937 DOI: 10.1038/362643a0  1
1993 Schroeder JE, McCleskey EW. Inhibition of Ca2+ currents by a mu-opioid in a defined subset of rat sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 867-73. PMID 7678862  1
1993 Fieber LA, McCleskey EW. L-type calcium channels in type I cells of the rat carotid body. Journal of Neurophysiology. 70: 1378-84. PMID 7506754  1
1991 Schroeder JE, Fischbach PS, Zheng D, McCleskey EW. Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current. Neuron. 6: 13-20. PMID 1846076 DOI: 10.1016/0896-6273(91)90117-I  1
1991 McCleskey EW, Schroeder JE. Functional properties of voltage-dependent calcium channels Current Topics in Membranes. 39: 295-326. DOI: 10.1016/S0070-2161(08)60807-2  1
1990 Schroeder JE, Fischbach PS, Mamo M, McCleskey EW. Two components of high-threshold Ca2+ current inactivate by different mechanisms. Neuron. 5: 445-52. PMID 2206532 DOI: 10.1016/0896-6273(90)90083-R  1
1990 Schroeder JE, Fischbach PS, McCleskey EW. T-type calcium channels: heterogeneous expression in rat sensory neurons and selective modulation by phorbol esters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 947-51. PMID 2156966  1
1988 Miller RJ, Ewald DA, Fox AP, Hirning LD, McCleskey EW, Perney TM, Sturek M, Thayer SA, Tsien RW, Walker MW. The effect of calcium channel antagonists on peripheral neurones. Annals of the New York Academy of Sciences. 522: 269-77. PMID 3288051  1
1988 Hirning LD, Fox AP, McCleskey EW, Olivera BM, Thayer SA, Miller RJ, Tsien RW. Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science (New York, N.Y.). 239: 57-61. PMID 2447647  1
1988 Rosenberg RL, McCleskey EW, Hess P, Tsien RW. Chapter 19 Cardiac Calcium Channels: Pore Size and Symmetry of Energy Profile Current Topics in Membranes and Transport. 33: 393-413. DOI: 10.1016/S0070-2161(08)60909-0  1
1987 Tsien RW, Hess P, McCleskey EW, Rosenberg RL. Calcium channels: mechanisms of selectivity, permeation, and block. Annual Review of Biophysics and Biophysical Chemistry. 16: 265-90. PMID 2439098 DOI: 10.1146/annurev.bb.16.060187.001405  1
1987 McCleskey EW, Fox AP, Feldman DH, Cruz LJ, Olivera BM, Tsien RW, Yoshikami D. Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proceedings of the National Academy of Sciences of the United States of America. 84: 4327-31. PMID 2438698 DOI: 10.1073/pnas.84.12.4327  1
1987 Tsien RW, Fox AP, Hess P, McCleskey EW, Nilius B, Nowycky MC, Rosenberg RL. Multiple types of calcium channel in excitable cells. Society of General Physiologists Series. 41: 167-87. PMID 2436308  1
1986 McCleskey EW, Fox AP, Feldman D, Tsien RW. Different types of calcium channels. The Journal of Experimental Biology. 124: 177-90. PMID 2428899  1
1985 Schwartz LM, McCleskey EW, Almers W. Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels. Nature. 314: 747-51. PMID 2581141 DOI: 10.1038/314747a0  1
1985 McCleskey EW. Calcium channels and intracellular calcium release are pharmacologically different in frog skeletal muscle. The Journal of Physiology. 361: 231-49. PMID 2580976 DOI: 10.1113/jphysiol.1985.sp015643  1
1985 McCleskey EW, Almers W. The Ca channel in skeletal muscle is a large pore. Proceedings of the National Academy of Sciences of the United States of America. 82: 7149-53. PMID 2413461  1
1984 Almers W, McCleskey EW. Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore. The Journal of Physiology. 353: 585-608. PMID 6090646 DOI: 10.1113/jphysiol.1984.sp015352  1
1984 Almers W, McCleskey EW, Palade PT. A non-selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions. The Journal of Physiology. 353: 565-83. PMID 6090645 DOI: 10.1113/jphysiol.1984.sp015351  1
1982 Almers W, McCleskey EW, Palade PT. Frog muscle membrane: A cation-permeable channel blocked by micromolar external [Ca2+] Journal of Physiology. 52P-53P.  1
1981 McCleskey E, Almers W. Pharmacological comparison of E.C. coupling and the skeletal muscle Ca++ channel Biophysical Journal 1
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