Hynek Wichterle, Ph.D. - Publications

Affiliations: 
Columbia University, New York, NY 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bos PH, Lowry ER, Costa J, Thams S, Garcia-Diaz A, Zask A, Wichterle H, Stockwell BR. Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents. Cell Chemical Biology. PMID 31676236 DOI: 10.1016/j.chembiol.2019.10.005  0.48
2019 Savchenko E, Teku GN, Boza-Serrano A, Russ K, Berns M, Deierborg T, Lamas NJ, Wichterle H, Rothstein J, Henderson CE, Vihinen M, Roybon L. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes. Scientific Reports. 9: 9610. PMID 31270389 DOI: 10.1038/s41598-019-46110-1  0.76
2019 An D, Fujiki R, Iannitelli DE, Smerdon JW, Maity S, Rose MF, Gelber A, Wanaselja EK, Yagudayeva I, Lee JY, Vogel C, Wichterle H, Engle EC, Mazzoni EO. Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. Elife. 8. PMID 31157617 DOI: 10.7554/eLife.44423  0.88
2019 Guo Y, Krismer K, Closser M, Wichterle H, Gifford DK. High resolution discovery of chromatin interactions. Nucleic Acids Research. 47: e35. PMID 30953075 DOI: 10.1093/nar/gkz051  0.4
2018 Thams S, Lowry ER, Larraufie MH, Spiller KJ, Li H, Williams DJ, Hoang P, Jiang E, Williams LA, Sandoe J, Eggan K, Lieberam I, Kanning KC, Stockwell BR, Henderson CE, ... Wichterle H, et al. A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 30446391 DOI: 10.1016/j.ymthe.2018.10.010  0.68
2018 Hoang PT, Chalif JI, Bikoff JB, Jessell TM, Mentis GZ, Wichterle H. Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons. Neuron. 100: 135-149.e7. PMID 30308166 DOI: 10.1016/j.neuron.2018.09.016  0.92
2018 Jacko M, Weyn-Vanhentenryck SM, Smerdon JW, Yan R, Feng H, Williams DJ, Pai J, Xu K, Wichterle H, Zhang C. Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly. Neuron. PMID 29398366 DOI: 10.1016/j.neuron.2018.01.020  0.36
2016 Rhee HS, Closser M, Guo Y, Bashkirova EV, Tan GC, Gifford DK, Wichterle H. Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers. Neuron. PMID 27939581 DOI: 10.1016/j.neuron.2016.11.037  0.8
2016 Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neuroscience. PMID 27428653 DOI: 10.1038/nn.4345  1
2016 Tan GC, Mazzoni EO, Wichterle H. Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification. Cell Reports. PMID 27425621 DOI: 10.1016/j.celrep.2016.06.067  0.88
2016 Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B, et al. Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth. Cell Reports. PMID 27373155 DOI: 10.1016/j.celrep.2016.06.013  0.76
2016 Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience. 16: 542-53. PMID 27021939 DOI: 10.1038/nn.4273  0.32
2015 Johnson-Kerner BL, Garcia Diaz A, Ekins S, Wichterle H. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. Plos One. 10: e0140157. PMID 26460568 DOI: 10.1371/journal.pone.0140157  1
2015 Reeder C, Closser M, Poh HM, Sandhu K, Wichterle H, Gifford D. High resolution mapping of enhancer-promoter interactions. Plos One. 10: e0122420. PMID 25970635 DOI: 10.1371/journal.pone.0122420  1
2015 Johnson-Kerner BL, Ahmad FS, Diaz AG, Greene JP, Gray SJ, Samulski RJ, Chung WK, Van Coster R, Maertens P, Noggle SA, Henderson CE, Wichterle H. Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin. Human Molecular Genetics. 24: 1420-31. PMID 25398950 DOI: 10.1093/hmg/ddu556  1
2015 Lamas NJ, Johnson-Kerner B, Roybon L, Kim YA, Garcia-Diaz A, Wichterle H. Correction: Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures Plos One. 10. DOI: 10.1371/journal.pone.0119195  1
2015 Peljto M, Wichterle H. Image analysis tools for quantification of spinal motor neuron subtype identities Methods in Pharmacology and Toxicology. 20: 127-139. DOI: 10.1007/7653_2014_15  1
2014 Lamas NJ, Johnson-Kerner B, Roybon L, Kim YA, Garcia-Diaz A, Wichterle H, Henderson CE. Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. Plos One. 9: e110324. PMID 25337699 DOI: 10.1371/journal.pone.0110324  1
2014 Johnson-Kerner BL, Roth L, Greene JP, Wichterle H, Sproule DM. Giant axonal neuropathy: An updated perspective on its pathology and pathogenesis. Muscle & Nerve. 50: 467-76. PMID 24947478 DOI: 10.1002/mus.24321  1
2014 Maldonado-Soto AR, Oakley DH, Wichterle H, Stein J, Doetsch FK, Henderson CE. Stem cells in the nervous system. American Journal of Physical Medicine & Rehabilitation / Association of Academic Physiatrists. 93: S132-44. PMID 24800720 DOI: 10.1097/PHM.0000000000000111  1
2014 Mahony S, Edwards MD, Mazzoni EO, Sherwood RI, Kakumanu A, Morrison CA, Wichterle H, Gifford DK. An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding. Plos Computational Biology. 10: e1003501. PMID 24675637 DOI: 10.1371/journal.pcbi.1003501  1
2014 Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, et al. Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. 81: 1001-8. PMID 24508385 DOI: 10.1016/j.neuron.2014.01.011  1
2013 Roybon L, Lamas NJ, Garcia-Diaz A, Yang EJ, Sattler R, Jackson-Lewis V, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE. Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Reports. 4: 1035-48. PMID 23994478 DOI: 10.1016/j.celrep.2013.06.021  1
2013 Mazzoni EO, Mahony S, Peljto M, Patel T, Thornton SR, McCuine S, Reeder C, Boyer LA, Young RA, Gifford DK, Wichterle H. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nature Neuroscience. 16: 1191-8. PMID 23955559 DOI: 10.1038/nn.3490  1
2013 Wichterle H, Gifford D, Mazzoni E. Neuroscience. Mapping neuronal diversity one cell at a time. Science (New York, N.Y.). 341: 726-7. PMID 23950522 DOI: 10.1126/science.1235884  1
2013 Mazzoni EO, Mahony S, Closser M, Morrison CA, Nedelec S, Williams DJ, An D, Gifford DK, Wichterle H. Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nature Neuroscience. 16: 1219-27. PMID 23872598 DOI: 10.1038/nn.3467  1
2013 Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 574-86. PMID 23303937 DOI: 10.1523/JNEUROSCI.0906-12.2013  1
2012 Takazawa T, Croft GF, Amoroso MW, Studer L, Wichterle H, Macdermott AB. Maturation of spinal motor neurons derived from human embryonic stem cells. Plos One. 7: e40154. PMID 22802953 DOI: 10.1371/journal.pone.0040154  1
2012 Hashimoto T, Jaakkola T, Sherwood R, Mazzoni EO, Wichterle H, Gifford D. Lineage-based identification of cellular states and expression programs. Bioinformatics (Oxford, England). 28: i250-7. PMID 22689769 DOI: 10.1093/bioinformatics/bts204  1
2012 Chen JA, Wichterle H. Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation. Frontiers in Neuroscience. 6: 69. PMID 22629237 DOI: 10.3389/fnins.2012.00069  1
2012 Nédelec S, Peljto M, Shi P, Amoroso MW, Kam LC, Wichterle H. Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1496-506. PMID 22279234 DOI: 10.1523/JNEUROSCI.4176-11.2012  1
2011 Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H. Embryonic stem cell-based mapping of developmental transcriptional programs. Nature Methods. 8: 1056-8. PMID 22081127 DOI: 10.1038/nmeth.1775  1
2011 Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 147: 132-46. PMID 21924763 DOI: 10.1016/j.cell.2011.08.023  1
2011 Chen JA, Huang YP, Mazzoni EO, Tan GC, Zavadil J, Wichterle H. Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron. 69: 721-35. PMID 21338882 DOI: 10.1016/j.neuron.2011.01.014  1
2011 Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, ... ... Wichterle H, et al. A functionally characterized test set of human induced pluripotent stem cells. Nature Biotechnology. 29: 279-86. PMID 21293464 DOI: 10.1038/nbt.1783  1
2011 Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, Gifford DK. Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. Genome Biology. 12: R2. PMID 21232103 DOI: 10.1186/gb-2011-12-1-r2  1
2011 Peljto M, Wichterle H. Programming embryonic stem cells to neuronal subtypes. Current Opinion in Neurobiology. 21: 43-51. PMID 20970319 DOI: 10.1016/j.conb.2010.09.012  1
2010 Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS. MicroRNA regulation of neural stem cells and neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14931-6. PMID 21068294 DOI: 10.1523/JNEUROSCI.4280-10.2010  1
2010 Jung H, Lacombe J, Mazzoni EO, Liem KF, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 67: 781-96. PMID 20826310 DOI: 10.1016/j.neuron.2010.08.008  1
2010 Peljto M, Dasen JS, Mazzoni EO, Jessell TM, Wichterle H. Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell. 7: 355-66. PMID 20804971 DOI: 10.1016/j.stem.2010.07.013  1
2010 Wichterle H, Przedborski S. What can pluripotent stem cells teach us about neurodegenerative diseases? Nature Neuroscience. 13: 800-4. PMID 20581816 DOI: 10.1038/nn.2577  1
2010 Mirzadeh Z, Doetsch F, Sawamoto K, Wichterle H, Alvarez-Buylla A. The subventricular zone en-face: wholemount staining and ependymal flow. Journal of Visualized Experiments : Jove. PMID 20461052 DOI: 10.3791/1938  1
2010 Shi P, Nedelec S, Wichterle H, Kam LC. Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding. Lab On a Chip. 10: 1005-10. PMID 20358107 DOI: 10.1039/b922143c  1
2009 Wichterle H, Peljto M, Nedelec S. Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord. Methods in Molecular Biology (Clifton, N.J.). 482: 171-83. PMID 19089356 DOI: 10.1007/978-1-59745-060-7_11  1
2008 Wichterle H, Peljto M. Differentiation of mouse embryonic stem cells to spinal motor neurons. Current Protocols in Stem Cell Biology. Unit 1H.1.1-1H.1.9. PMID 18770634 DOI: 10.1002/9780470151808.sc01h01s5  1
2008 Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (New York, N.Y.). 321: 1218-21. PMID 18669821 DOI: 10.1126/science.1158799  1
2007 Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nature Neuroscience. 10: 615-22. PMID 17435755 DOI: 10.1038/nn1876  1
2006 Zhang H, Xing L, Rossoll W, Wichterle H, Singer RH, Bassell GJ. Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8622-32. PMID 16914688 DOI: 10.1523/JNEUROSCI.3967-05.2006  1
2006 Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 1551-6. PMID 16432183 DOI: 10.1073/pnas.0510658103  1
2006 Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Okano H, Alvarez-Buylla A. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (New York, N.Y.). 311: 629-32. PMID 16410488 DOI: 10.1126/science.1119133  1
2004 Miles GB, Yohn DC, Wichterle H, Jessell TM, Rafuse VF, Brownstone RM. Functional properties of motoneurons derived from mouse embryonic stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7848-58. PMID 15356197 DOI: 10.1523/JNEUROSCI.1972-04.2004  1
2003 Novitch BG, Wichterle H, Jessell TM, Sockanathan S. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron. 40: 81-95. PMID 14527435 DOI: 10.1016/j.neuron.2003.08.006  1
2003 Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proceedings of the National Academy of Sciences of the United States of America. 100: 4616-21. PMID 12679522 DOI: 10.1073/pnas.0732813100  1
2003 Wichterle H, Alvarez-Dolado M, Erskine L, Alvarez-Buylla A. Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex. Proceedings of the National Academy of Sciences of the United States of America. 100: 727-32. PMID 12515855 DOI: 10.1073/pnas.242721899  1
2002 Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. Journal of Biology. 1: 10. PMID 12437772 DOI: 10.1186/1475-4924-1-10  1
2002 Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell. 110: 385-97. PMID 12176325 DOI: 10.1016/S0092-8674(02)00835-8  1
2001 Wichterle H, Turnbull DH, Nery S, Fishell G, Alvarez-Buylla A. In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain. Development (Cambridge, England). 128: 3759-71. PMID 11585802  1
2001 Nery S, Wichterle H, Fishell G. Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development (Cambridge, England). 128: 527-40. PMID 11171336  1
2000 Alvarez-Buylla A, Herrera DG, Wichterle H. The subventricular zone: source of neuronal precursors for brain repair. Progress in Brain Research. 127: 1-11. PMID 11142024 DOI: 10.1016/S0079-6123(00)27002-7  1
1999 Wichterle H, Garcia-Verdugo JM, Herrera DG, Alvarez-Buylla A. Young neurons from medial ganglionic eminence disperse in adult and embryonic brain. Nature Neuroscience. 2: 461-6. PMID 10321251 DOI: 10.1038/8131  1
1998 García-Verdugo JM, Doetsch F, Wichterle H, Lim DA, Alvarez-Buylla A. Architecture and cell types of the adult subventricular zone: in search of the stem cells. Journal of Neurobiology. 36: 234-48. PMID 9712307 DOI: 10.1002/(SICI)1097-4695(199808)36:2<234::AID-NEU10>3.0.CO;2-E  1
1997 Wichterle H, Garcia-Verdugo JM, Alvarez-Buylla A. Direct evidence for homotypic, glia-independent neuronal migration. Neuron. 18: 779-91. PMID 9182802 DOI: 10.1016/S0896-6273(00)80317-7  1
1996 Wichterle H, Hanspal M, Palek J, Jarolim P. Combination of two mutant alpha spectrin alleles underlies a severe spherocytic hemolytic anemia. The Journal of Clinical Investigation. 98: 2300-7. PMID 8941647 DOI: 10.1172/JCI119041  1
1995 Jarolim P, Wichterle H, Hanspal M, Murray J, Rubin HL, Palek J. Beta spectrin PRAGUE: a truncated beta spectrin producing spectrin deficiency, defective spectrin heterodimer self-association and a phenotype of spherocytic elliptocytosis. British Journal of Haematology. 91: 502-10. PMID 8547102  1
1995 Jarolim P, Rubin HL, Brabec V, Chrobak L, Zolotarev AS, Alper SL, Brugnara C, Wichterle H, Palek J. Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis. Blood. 85: 634-40. PMID 7530501  1
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