| Year |
Citation |
Score |
| 2013 |
de Leede LG, de Boer AG, Havermans JP, Breimer DD. Avoidance of "first-pass" elimination of rectally administered propranolol in relation to the site of absorption in rats. Pharmaceutical Research. 1: 164-8. PMID 24277285 DOI: 10.1023/A:1016396508058 |
0.39 |
|
| 2013 |
de Leede LG, de Boer AG, Feijen CD, Breimer DD. Site specific rectal drug administration in man with an osmotic system: influence on "first-pass" elimination of lidocaine. Pharmaceutical Research. 1: 129-34. PMID 24277250 DOI: 10.1023/A:1016380104424 |
0.394 |
|
| 2013 |
Teunissen MW, Brorens IO, De Langen HJ, Geerlings AM, Breimer DD. Correlation between in vivo antipyrine metabolite formation and theophylline metabolism in rats. Pharmaceutical Research. 3: 156-61. PMID 24271521 DOI: 10.1023/A:1016361907787 |
0.361 |
|
| 2001 |
van der Sandt IC, Gaillard PJ, Voorwinden HH, de Boer AG, Breimer DD. P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtubule cytostatics at the in vitro blood-brain barrier. Pharmaceutical Research. 18: 587-92. PMID 11465412 DOI: 10.1023/A:1011016923346 |
0.313 |
|
| 2000 |
de Lange EC, de Boer AG, Breimer DD. Methodological issues in microdialysis sampling for pharmacokinetic studies. Advanced Drug Delivery Reviews. 45: 125-48. PMID 11108971 DOI: 10.1016/S0169-409X(00)00107-1 |
0.326 |
|
| 1999 |
de Lange EC, de Boer BA, Breimer DD. Microdialysis for pharmacokinetic analysis of drug transport to the brain. Advanced Drug Delivery Reviews. 36: 211-227. PMID 10837717 DOI: 10.1016/S0169-409X(98)00089-1 |
0.315 |
|
| 1997 |
Mulders TM, Bergman DJ, Poll-The BT, Smit GP, Breimer DD, Mulder GJ, Duran M, Smeitink JA. Abnormal glutathione conjugation in patients with tyrosinaemia type I. Journal of Inherited Metabolic Disease. 20: 473-85. PMID 9266383 DOI: 10.1023/A:1005385009831 |
0.332 |
|
| 1997 |
Grouls RJ, Meert TF, Korsten HH, Hellebrekers LJ, Breimer DD. Epidural and intrathecal n-butyl-p-aminobenzoate solution in the rat. Comparison with bupivacaine. Anesthesiology. 86: 181-7. PMID 9009953 DOI: 10.1097/00000542-199701000-00022 |
0.307 |
|
| 1997 |
De Boer AG, Breimer DD. Hepatic first-pass effect and controlled drug delivery following rectal administration Advanced Drug Delivery Reviews. 28: 229-237. DOI: 10.1016/S0169-409X(97)00074-4 |
0.342 |
|
| 1996 |
Mathot RA, Wenden EM, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo. The Journal of Pharmacology and Experimental Therapeutics. 279: 1439-46. PMID 8968369 |
0.634 |
|
| 1996 |
Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, et al. Evaluation of orally administered highly variable drugs and drug formulations Pharmaceutical Research. 13: 1590-1594. PMID 8956322 DOI: 10.1023/A:1016468018478 |
0.305 |
|
| 1996 |
Mathoôt RA, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. British Journal of Pharmacology. 118: 369-77. PMID 8735640 DOI: 10.1111/J.1476-5381.1996.Tb15412.X |
0.587 |
|
| 1996 |
De Boer AG, Breimer DD. Reconstitution of the blood-brain barrier in cell culture for studies of drug transport and metabolism Advanced Drug Delivery Reviews. 22: 251-264. DOI: 10.1016/S0169-409X(96)00421-8 |
0.302 |
|
| 1995 |
de Vries HE, Eppens EF, Prins M, Kuiper J, van Berkel TJ, de Boer AG, Breimer DD. Transport of a hydrophilic compound into the cerebrospinal fluid during experimental allergic encephalomyelitis and after lipopolysaccharide administration. Pharmaceutical Research. 12: 1932-6. PMID 8786968 DOI: 10.1023/A:1016291806357 |
0.329 |
|
| 1995 |
de Lange EC, Bouw MR, Mandema JW, Danhof M, de Boer AG, Breimer DD. Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain. British Journal of Pharmacology. 116: 2538-44. PMID 8581296 DOI: 10.1111/J.1476-5381.1995.Tb15107.X |
0.346 |
|
| 1995 |
de Lange EC, Hesselink MB, Danhof M, de Boer AG, Breimer DD. The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics. Pharmaceutical Research. 12: 129-33. PMID 7724474 DOI: 10.1023/A:1016207208406 |
0.309 |
|
| 1995 |
Mathôt RA, Van den Aarsen BC, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats. The Journal of Pharmacology and Experimental Therapeutics. 273: 405-14. PMID 7714796 |
0.713 |
|
| 1995 |
Noach AB, Blom-Roosemalen MC, De Boer AG, Breimer DD. Absorption enhancement of a hydrophilic model compound by verapamil after rectal administration to rats. The Journal of Pharmacy and Pharmacology. 47: 466-8. PMID 7545750 DOI: 10.1111/J.2042-7158.1995.Tb05832.X |
0.386 |
|
| 1994 |
van Steveninck AL, Schoemaker HC, den Hartigh J, Pieters MS, Breimer DD, Cohen AF. Effects of intravenous temazepam. II. A study of the long-term reproducibility of pharmacokinetics, pharmacodynamics, and concentration-effect parameters. Clinical Pharmacology and Therapeutics. 55: 546-55. PMID 8181199 DOI: 10.1038/Clpt.1994.68 |
0.325 |
|
| 1994 |
van Steveninck AL, Schoemaker HC, den Hartigh J, Rijnkels J, Pieters MS, Breimer DD, Cohen AF. Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state. Clinical Pharmacology and Therapeutics. 55: 535-45. PMID 8181198 DOI: 10.1038/Clpt.1994.67 |
0.344 |
|
| 1994 |
Masereeuw R, Jaehde U, Langemeijer MW, de Boer AG, Breimer DD. In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors. Pharmaceutical Research. 11: 324-30. PMID 8165196 DOI: 10.1023/A:1018932213953 |
0.307 |
|
| 1994 |
Mathôt RA, van Schaick EA, Langemeijer MW, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat. The Journal of Pharmacology and Experimental Therapeutics. 268: 616-24. PMID 8113972 |
0.732 |
|
| 1993 |
Soons PA, Mulders TM, Uchida E, Schoemaker HC, Cohen AF, Breimer DD. Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics. European Journal of Clinical Pharmacology. 44: 163-9. PMID 8453961 DOI: 10.1007/Bf00315475 |
0.373 |
|
| 1993 |
Soons PA, Cohen AF, Breimer DD. Comparative effects of felodipine, nitrendipine and nifedipine in healthy subjects: concentration-effect relationships of racemic drugs and enantiomers. European Journal of Clinical Pharmacology. 44: 113-20. PMID 8453956 DOI: 10.1007/Bf00315467 |
0.349 |
|
| 1993 |
Cohen AF, Kroon R, Schoemaker HC, Breimer DD, Van Vliet-Verbeek A, Brandenburg HC. The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay. British Journal of Clinical Pharmacology. 35: 136-42. PMID 8443031 DOI: 10.1111/J.1365-2125.1993.Tb05679.X |
0.341 |
|
| 1993 |
Mulders TM, Venizelos V, Schoemaker R, Cohen AF, Breimer DD, Mulder GJ. Characterization of glutathione conjugation in humans: stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers. Clinical Pharmacology and Therapeutics. 53: 49-58. PMID 8422741 DOI: 10.1038/Clpt.1993.8 |
0.36 |
|
| 1993 |
Mulders TM, van Ommen B, van Bladeren PJ, Breimer DD, Mulder GJ. Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers. Biochemical Pharmacology. 46: 1775-80. PMID 8250963 DOI: 10.1016/0006-2952(93)90582-H |
0.312 |
|
| 1993 |
Roos RA, Tijssen MA, van der Velde EA, Breimer DD. The influence of a standard meal on Sinemet CR absorption in patients with Parkinson's disease. Clinical Neurology and Neurosurgery. 95: 215-9. PMID 8242964 DOI: 10.1016/0303-8467(93)90126-2 |
0.3 |
|
| 1993 |
Van Rooij J, Schoemaker HC, Bruno R, Reinhoudt JF, Breimer DD, Cohen AF. Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine. British Journal of Clinical Pharmacology. 35: 661-3. PMID 8101096 DOI: 10.1111/J.1365-2125.1993.Tb04199.X |
0.35 |
|
| 1992 |
Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers. Clinical Pharmacology and Therapeutics. 51: 715-28. PMID 1611810 DOI: 10.1038/Clpt.1992.84 |
0.309 |
|
| 1992 |
Venizelos V, Irth H, Tjaden UR, van der Greef J, Breimer DD, Mulders TM, Mulder GJ. Enantioselective determination of R- and S-(alpha-bromoisovaleryl)urea in plasma using high-performance liquid chromatography after solid-phase extraction. Journal of Chromatography. 573: 259-64. PMID 1601958 DOI: 10.1016/0378-4347(92)80127-C |
0.322 |
|
| 1992 |
Soons PA, van den Berg G, Danhof M, van Brummelen P, Jansen JBMJ, Lamers CBHW, Breimer DD. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects European Journal of Clinical Pharmacology. 42: 319-324. PMID 1577051 DOI: 10.1007/Bf00266355 |
0.301 |
|
| 1992 |
Soons PA, Schoemaker HC, Cohen AF, Breimer DD. Intraindividual variability in nifedipine pharmacokinetics and effects in healthy subjects. Journal of Clinical Pharmacology. 32: 324-31. PMID 1569235 DOI: 10.1002/J.1552-4604.1992.Tb03843.X |
0.323 |
|
| 1992 |
Soons PA, Ankermann T, Breimer DD, Kirch W. Stereoselective pharmacokinetics of oral nitrendipine in elderly hypertensive patients with normal and impaired renal function European Journal of Clinical Pharmacology. 42: 423-427. PMID 1516607 DOI: 10.1007/Bf00280129 |
0.345 |
|
| 1992 |
Soons PA, Grib C, Breimer DD, Kirch W. Effects of acute febrile infectious diseases on the oral pharmacokinetics and effects of nitrendipine enantiomers and of bisoprolol. Clinical Pharmacokinetics. 23: 238-48. PMID 1355019 DOI: 10.2165/00003088-199223030-00006 |
0.335 |
|
| 1991 |
Schellens JH, Soons PA, van der Wart JH, Hoevers JW, Breimer DD. Lack of pharmacokinetic interaction between nifedipine, sparteine and phenytoin in man. British Journal of Clinical Pharmacology. 31: 175-8. PMID 2049233 DOI: 10.1111/J.1365-2125.1991.Tb05508.X |
0.536 |
|
| 1991 |
van Bree JBMM, Heijligers-Feijen CD, de Boer AG, Danhof M, Breimer DD. Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 259-262. PMID 2023878 DOI: 10.1023/A:1015812725011 |
0.325 |
|
| 1991 |
Schellens JH, Ghabrial H, van der Wart HH, Bakker EN, Wilkinson GR, Breimer DD. Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans. Clinical Pharmacology and Therapeutics. 50: 520-8. PMID 1934865 DOI: 10.1038/clpt.1991.177 |
0.474 |
|
| 1991 |
Soons PA, Vogels BA, Roosemalen MC, Schoemaker HC, Uchida E, Edgar B, Lundahl J, Cohen AF, Breimer DD. Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans. Clinical Pharmacology and Therapeutics. 50: 394-403. PMID 1914375 DOI: 10.1038/Clpt.1991.156 |
0.377 |
|
| 1991 |
Schellens JH, Van Haelst IM, Houston JB, Breimer DD. Nonlinear first-pass metabolism of nifedipine in healthy subjects. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 21: 547-55. PMID 1897253 DOI: 10.3109/00498259109039494 |
0.465 |
|
| 1991 |
Soons PA, Breimer DD. Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy male subjects British Journal of Clinical Pharmacology. 32: 11-16. PMID 1888628 DOI: 10.1111/J.1365-2125.1991.Tb05606.X |
0.366 |
|
| 1991 |
van Hoogdalem EJ, de Boer AG, Breimer DD. Pharmacokinetics of Rectal Drug Administration, Part II: Clinical Applications of Peripherally Acting Drugs, and Conclusions Clinical Pharmacokinetics. 21: 110-128. PMID 1884566 DOI: 10.2165/00003088-199121020-00003 |
0.306 |
|
| 1991 |
Roosemalen MCM, Soons PA, Funaki T, Breimer DD. High-performance liquid chromatographic determination of the polar metabolites of nifedipine in plasma, blood and urine Journal of Chromatography B: Biomedical Sciences and Applications. 565: 516-522. PMID 1874901 DOI: 10.1016/0378-4347(91)80419-D |
0.305 |
|
| 1991 |
Soons PA, De Boer A, Cohen AF, Breimer DD. Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green British Journal of Clinical Pharmacology. 32: 697-704. PMID 1768562 DOI: 10.1111/J.1365-2125.1991.Tb03976.X |
0.38 |
|
| 1991 |
de Boer A, Stiekema JCJ, Danhof M, Moolenaar AJ, Breimer DD. Interaction of ORG 10172, a low molecular weight heparinoid, and digoxin in healthy volunteers European Journal of Clinical Pharmacology. 41: 245-250. PMID 1748141 DOI: 10.1007/Bf00315437 |
0.348 |
|
| 1991 |
Soons PA, Schellens JH, Roosemalen MC, Breimer DD. Analysis of nifedipine and its pyridine metabolite dehydronifedipine in blood and plasma: review and improved high-performance liquid chromatographic methodology. Journal of Pharmaceutical and Biomedical Analysis. 9: 475-84. PMID 1747400 DOI: 10.1016/0731-7085(91)80249-9 |
0.494 |
|
| 1991 |
De Boer A, Danhof M, Cohen AF, Magnani HN, Breimer DD. Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers Thrombosis and Haemostasis. 66: 202-207. PMID 1722918 DOI: 10.1055/S-0038-1646390 |
0.328 |
|
| 1991 |
De Boer A, Stiekema JC, Danhof M, Breimer DD. Influence of chlorthalidone on the pharmacokinetics and pharmacodynamics of Org 10172 (Lomoparan®), a low molecular weight heparinoid, in healthy volunteers Journal of Clinical Pharmacology. 31: 611-617. PMID 1716644 DOI: 10.1002/J.1552-4604.1991.Tb03746.X |
0.329 |
|
| 1991 |
De Boer A, Stiekema JCJ, Danhof M, Breimer DD. The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172 British Journal of Clinical Pharmacology. 32: 23-29. PMID 1716140 DOI: 10.1111/J.1365-2125.1991.Tb05608.X |
0.335 |
|
| 1990 |
Soons PA, Kroon JM, Breimer DD. Effects of single-dose and short-term oral nifedipine on indocyanine green clearance as assessed by spectrophotometry and high performance liquid chromatography Journal of Clinical Pharmacology. 30: 693-698. PMID 2401748 DOI: 10.1002/J.1552-4604.1990.Tb03628.X |
0.352 |
|
| 1990 |
Cohen AF, van Hall MA, van Harten J, Schoemaker RC, Johansson P, Breimer DD, Visser R, Edgar B. The influence of infusion rate on the hemodynamic effects of felodipine. Clinical Pharmacology and Therapeutics. 48: 309-17. PMID 2401128 DOI: 10.1038/Clpt.1990.154 |
0.369 |
|
| 1990 |
Soons PA, Roosemalen MCM, Breimer DD. Enantioselective determination of felodipine and other chiral dihydropyridine calcium entry blockers in human plasma Journal of Chromatography B: Biomedical Sciences and Applications. 528: 343-356. PMID 2384574 DOI: 10.1016/S0378-4347(00)82393-2 |
0.325 |
|
| 1990 |
Schellens JH, van der Wart JH, Breimer DD. Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects. British Journal of Clinical Pharmacology. 29: 665-71. PMID 2378787 DOI: 10.1111/J.1365-2125.1990.Tb03687.X |
0.491 |
|
| 1990 |
van Bree JBMM, Tio S, de Boer AG, Verhoef JC, Breimer DD. Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response Methodology Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 293-298. PMID 2339105 DOI: 10.1023/A:1015838532048 |
0.327 |
|
| 1990 |
Dingemanse J, Voskuyl RA, Langemeijer MW, Postel-Westra I, Breimer DD, Meinardi H, Danhof M. Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats. British Journal of Pharmacology. 99: 53-8. PMID 2331575 DOI: 10.1111/J.1476-5381.1990.Tb14653.X |
0.39 |
|
| 1990 |
Van Hoogdalem EJ, Vermeij-Kerrs C, De Boer AG, Breimer DD. Topical effects of absorption enhancing agents on the rectal mucosa of rats in vivo Journal of Pharmaceutical Sciences. 79: 866-870. PMID 2280353 DOI: 10.1002/Jps.2600791004 |
0.345 |
|
| 1990 |
de Boer AG, van Hoogdalem EJ, Breimer DD. Improvement of drug absorption through enhancers European Journal of Drug Metabolism and Pharmacokinetics. 15: 155-157. PMID 2200684 DOI: 10.1007/Bf03190198 |
0.322 |
|
| 1990 |
Breimer DD, Schellens JH. A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans. Trends in Pharmacological Sciences. 11: 223-5. PMID 2200179 DOI: 10.1016/0165-6147(90)90245-4 |
0.466 |
|
| 1990 |
De Boer AG, van Hoogdalem EJ, Heijligers-Feijen CD, Verhoef J, Breimer DD. Rectal absorption enhancement of peptide drugs Journal of Controlled Release. 13: 241-246. DOI: 10.1016/0168-3659(90)90014-K |
0.335 |
|
| 1990 |
Groen K, Jansen EJ, Brouwer A, Breimer DD, Van Bezooijen KFA. The influence of dietary restriction on P-450 mediated drug metabolism European Journal of Pharmacology. 183: 1574-1575. DOI: 10.1016/0014-2999(90)94737-I |
0.305 |
|
| 1990 |
van Bezooijen KFA, Groen K, Breimer DD. The influence of age on drug metabolism: in vivo and in vitro studies European Journal of Pharmacology. 183: 1629-1630. DOI: 10.1016/0014-2999(90)91917-Z |
0.306 |
|
| 1989 |
Watanabe Y, van Hoogdalem EJ, de Boer AG, Breimer DD. Absorption enhancement of rectally infused cefoxitin by medium chain monoglycerides in conscious rats. Journal of Pharmaceutical Sciences. 77: 847-9. PMID 3236226 DOI: 10.1002/Jps.2600771007 |
0.37 |
|
| 1989 |
Soons PA, Breimer DD. Gas chromatographic analysis of nitrendipine and its pyridine metabolite in human plasma. Journal of Chromatography. 428: 362-8. PMID 3215939 DOI: 10.1016/S0378-4347(00)83929-8 |
0.32 |
|
| 1989 |
van Hoogdalem EJ, Heijligers-Feijen CD, Mathôt RA, Wackwitz AT, van Bree JB, Verhoef JC, de Boer AG, Breimer DD. Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats. The Journal of Pharmacology and Experimental Therapeutics. 251: 741-4. PMID 2810123 |
0.629 |
|
| 1989 |
Van Harten J, Van Brummelen P, Ooms P, Danhof M, Blauw GJ, Breimer DD. Variability in the pharmacokinetics of nisoldipine as caused by differences in liver blood flow response Journal of Clinical Pharmacology. 29: 714-721. PMID 2778091 DOI: 10.1002/J.1552-4604.1989.Tb03405.X |
0.317 |
|
| 1989 |
Te Koppele JM, Schipper C, Breimer DD, Mulder GJ. Stereoselectivity in the urinary excretion of the mercapturates of (R)- and (S-) α-bromoisovalerylurea in man British Journal of Clinical Pharmacology. 28: 151-154. PMID 2775620 DOI: 10.1111/J.1365-2125.1989.Tb05407.X |
0.314 |
|
| 1989 |
Van Harten J, Burggraaf J, Danhof M, Van Brummelen P, Breimer DD. The contribution of nisoldipine-induced changes in liver blood flow to its pharmacokinetics after oral administration British Journal of Clinical Pharmacology. 27: 581-586. PMID 2757881 DOI: 10.1111/J.1365-2125.1989.Tb03420.X |
0.317 |
|
| 1989 |
Harten Jv, Burggraaf J, Ligthart GJ, Brummelen Pv, Breimer DD. Single- and multiple-dose nisoldipine kinetics and effects in the young, the middle-aged, and the elderly. Clinical Pharmacology & Therapeutics. 45: 600-607. PMID 2731403 DOI: 10.1038/Clpt.1989.80 |
0.308 |
|
| 1989 |
Schellens JH, van der Wart JH, Brugman M, Breimer DD. Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design. The Journal of Pharmacology and Experimental Therapeutics. 249: 638-45. PMID 2724144 |
0.42 |
|
| 1989 |
Soons PA, De Boer AG, Van Brummelen P, Breimer DD. Oral absorption profile of nitrendipine in healthy subjects: A kinetic and dynamic study British Journal of Clinical Pharmacology. 27: 179-189. PMID 2713213 DOI: 10.1111/J.1365-2125.1989.Tb05349.X |
0.395 |
|
| 1989 |
Van Hoogdalem EJ, Wackwitz AT, De Boer AG, Cohen AF, Breimer DD. Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers. British Journal of Clinical Pharmacology. 27: 75-81. PMID 2706190 DOI: 10.1111/J.1365-2125.1989.Tb05337.X |
0.347 |
|
| 1989 |
van Bree JBMM, Baljet AV, van Geyt A, de Boer AG, Danhof M, Breimer DD. The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system Journal of Pharmacokinetics and Biopharmaceutics. 17: 441-462. PMID 2614681 DOI: 10.1007/Bf01061457 |
0.319 |
|
| 1989 |
Funaki T, Soons PA, Guenoerich FP, Breimer DD. In vivo oxidative cleavage of a pyridinecarboxylic acid ester metabolite of nifedipine Biochemical Pharmacology. 38: 4213-4216. PMID 2597191 DOI: 10.1016/0006-2952(89)90517-0 |
0.303 |
|
| 1989 |
Van Hoogdalem EJ, Wackwitz ATE, De Boer AG, Breimer DD. 3-Amino-1-hydroxypropylidene-1,1-diphosphonate (APD): A novel enhancer of rectal cefoxitin absorption in rats Journal of Pharmacy and Pharmacology. 41: 339-341. PMID 2569522 DOI: 10.1111/J.2042-7158.1989.Tb06468.X |
0.324 |
|
| 1989 |
Breimer DD, Schellens JH, Soons PA. Nifedipine: variability in its kinetics and metabolism in man. Pharmacology & Therapeutics. 44: 445-54. PMID 2519350 DOI: 10.1016/0163-7258(89)90010-7 |
0.392 |
|
| 1989 |
Schellens JH, Janssens AR, van der Wart JH, van der Velde EA, Breimer DD. Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approach. European Journal of Clinical Investigation. 19: 472-9. PMID 2511024 DOI: 10.1111/J.1365-2362.1989.Tb00262.X |
0.507 |
|
| 1988 |
Van Harten J, Lodewijks MT, Guyt-Scholten JW, Van Brummelen P, Breimer DD. Gas chromatographic determination of nisoldipine and one of its metabolites in plasma. Journal of Chromatography. 423: 327-33. PMID 3443667 DOI: 10.1016/0378-4347(87)80359-6 |
0.329 |
|
| 1988 |
van Bree JB, de Boer AG, Danhof M, Verhoef JC, van Wimersma Greidanus TB, Breimer DD. Radioimmunoassay of desglycinamide-arginine vasopressin and its application in a pharmacokinetic study in the rat. Peptides. 9: 555-9. PMID 3420013 DOI: 10.1016/0196-9781(88)90163-5 |
0.386 |
|
| 1988 |
Dingemanse J, Sollie FA, Breimer DD, Danhof M. Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure. Journal of Pharmacokinetics and Biopharmaceutics. 16: 203-28. PMID 3418496 DOI: 10.1007/Bf01062261 |
0.365 |
|
| 1988 |
van Harten J, van Brummelen P, Wilson JH, Lodewijks MT, Breimer DD. Nisoldipine: kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration. European Journal of Clinical Pharmacology. 34: 387-94. PMID 3402524 DOI: 10.1007/Bf00542441 |
0.356 |
|
| 1988 |
Van Hoogdalem EJ, De Boer AG, Breimer DD. Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Pharmaceutisch Weekblad. Scientific Edition. 10: 76-9. PMID 3393421 DOI: 10.1007/Bf01962682 |
0.304 |
|
| 1988 |
Schellens JH, Soons PA, Breimer DD. Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects. Biochemical Pharmacology. 37: 2507-10. PMID 3390213 DOI: 10.1016/0006-2952(88)90238-9 |
0.444 |
|
| 1988 |
Joeres RP, Vermeulen NP, Breimer DD. Influence of the rate of hepatic portal vein infusion on hexobarbital pharmacokinetics in the rat. Pharmacology. 36: 210-6. PMID 3368506 DOI: 10.1159/000138386 |
0.58 |
|
| 1988 |
Burm AG, de Boer AG, van Kleef JW, Vermeulen NP, de Leede LG, Spierdijk J, Breimer DD. Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers. Biopharmaceutics & Drug Disposition. 9: 85-95. PMID 3342287 DOI: 10.1002/Bod.2510090109 |
0.567 |
|
| 1988 |
Dingemanse J, Danhof M, Breimer DD. Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview. Pharmacology & Therapeutics. 38: 1-52. PMID 3293088 DOI: 10.1016/0163-7258(88)90101-5 |
0.307 |
|
| 1988 |
Schellens JH, van der Wart HH, Hoevers JW, Breimer DD. Gas chromatographic determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine. Journal of Chromatography. 431: 203-9. PMID 3235532 DOI: 10.1016/S0378-4347(00)83086-8 |
0.476 |
|
| 1988 |
Schellens JH, van der Wart JH, Danhof M, van der Velde EA, Breimer DD. Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach. British Journal of Clinical Pharmacology. 26: 373-84. PMID 3190987 DOI: 10.1111/J.1365-2125.1988.Tb03394.X |
0.506 |
|
| 1988 |
Burm AG, Van Kleef JW, Vermeulen NP, Olthof G, Breimer DD, Spierdijk J. Pharmacokinetics of lidocaine and bupivacaine following subarachnoid administration in surgical patients: simultaneous investigation of absorption and disposition kinetics using stable isotopes. Anesthesiology. 69: 584-92. PMID 3177919 DOI: 10.1097/00000542-198810000-00020 |
0.563 |
|
| 1988 |
van der Graaff M, Vermeulen NP, Breimer DD. Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metabolism Reviews. 19: 109-64. PMID 3069420 DOI: 10.3109/03602538809049621 |
0.456 |
|
| 1988 |
Van Hoogdalem EJ, Geerts JA, De Boer AG, Breimer DD. The influence of components on the rectal absorption of cefazolin in rats. The Journal of Pharmacy and Pharmacology. 40: 815-7. PMID 2907567 DOI: 10.1111/J.2042-7158.1988.Tb05181.X |
0.312 |
|
| 1988 |
Hoogdalem EJ, Stijnen AM, Boer AG, Breimer DD. Rate-controlled absorption enhancement of rectally administered cefazolin in rats by a glyceride mixture (MGK). Journal of Pharmacy and Pharmacology. 40: 329-332. PMID 2899627 DOI: 10.1111/J.2042-7158.1988.Tb05261.X |
0.33 |
|
| 1987 |
Cohen AF, Land GS, Breimer DD, Yuen WC, Winton C, Peck AW. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clinical Pharmacology and Therapeutics. 42: 535-41. PMID 3677542 DOI: 10.1038/Clpt.1987.193 |
0.385 |
|
| 1987 |
Burm AG, Vermeulen NP, van Kleef JW, de Boer AG, Spierdijk J, Breimer DD. Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration. Simultaneous investigation of absorption and disposition kinetics using stable isotopes. Clinical Pharmacokinetics. 13: 191-203. PMID 3665324 DOI: 10.2165/00003088-198713030-00004 |
0.544 |
|
| 1987 |
van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. Correlation of apparent intrinsic clearances of simultaneously administered S (+) and d3R (-) hexobarbital in the rat. Biochemical Pharmacology. 36: 1321-3. PMID 3593417 DOI: 10.1016/0006-2952(87)90088-8 |
0.543 |
|
| 1987 |
Schellens JH, Breimer DD. Variability in drug metabolism: importance of genetic constitution. Pharmaceutisch Weekblad. Scientific Edition. 9: 85-90. PMID 3295765 DOI: 10.1007/Bf01960741 |
0.501 |
|
| 1987 |
Breimer DD. Pharmacokinetics in liver disease. Pharmaceutisch Weekblad. Scientific Edition. 9: 79-84. PMID 3295764 DOI: 10.1007/Bf01960740 |
0.318 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Heij P, de Bree H, Breimer DD. Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 16: 1091-6. PMID 3798956 DOI: 10.3109/00498258609038986 |
0.564 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Vinks MH, Breimer DD. Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat. European Journal of Drug Metabolism and Pharmacokinetics. 11: 107-11. PMID 3770011 DOI: 10.1007/Bf03189835 |
0.519 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Koperdraat MC, Breimer DD. Non-linear pharmacokinetics of sparteine in the rat. Archives Internationales De Pharmacodynamie Et De ThéRapie. 282: 181-95. PMID 3767526 |
0.529 |
|
| 1986 |
Kleinbloesem CH, van Brummelen P, Woittiez AJ, Faber H, Breimer DD. Influence of haemodialysis on the pharmacokinetics and haemodynamic effects of nifedipine during continuous intravenous infusion. Clinical Pharmacokinetics. 11: 316-22. PMID 3757391 DOI: 10.2165/00003088-198611040-00004 |
0.36 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Heij P, Boeijinga JK, Breimer DD. Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects. Biopharmaceutics & Drug Disposition. 7: 265-72. PMID 3730526 DOI: 10.1002/Bdd.2510070307 |
0.567 |
|
| 1986 |
Kleinbloesem CH, Harten Jv, Wilson JPH, Danhof M, Brummelen Pv, Breimer DD. Nifedipine: Kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration Clinical Pharmacology & Therapeutics. 40: 21-28. PMID 3720176 DOI: 10.1038/Clpt.1986.134 |
0.324 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Breimer DD. Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Pharmaceutisch Weekblad. Scientific Edition. 8: 139-44. PMID 3714437 DOI: 10.1007/Bf02086148 |
0.567 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. Stereospecific analysis of racemic hexobarbital in rat blood by enantioselective capillary gas chromatography. Journal of Chromatography. 375: 411-5. PMID 3700566 DOI: 10.1016/S0378-4347(00)83736-6 |
0.53 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. The influence of pretreatment on the urinary metabolite profile of pseudoracemic hexobarbital. Biochemical Pharmacology. 35: 3166-9. PMID 3092834 DOI: 10.1016/0006-2952(86)90404-1 |
0.531 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Crul IE, Breimer DD. Dose-dependent pharmacokinetics of zoxazolamine in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 14: 331-5. PMID 2872034 |
0.479 |
|
| 1986 |
Jochemsen R, van Rijn PA, Hazelzet TG, van Boxtel CJ, Breimer DD. Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration. Biopharmaceutics & Drug Disposition. 7: 53-61. PMID 2869795 DOI: 10.1002/Bdd.2510070108 |
0.388 |
|
| 1986 |
Burm AG, van KLeef JW, Vermeulen NP, Breimer DD, Spierdijk J. ABSORPTION KINETICS OF LICOCAINE AND BUFTVACAINE FOLLOWING EPIDURAL AND SUBARACHNOID ADMINISTRATION Anesthesiology. 65: A207. DOI: 10.1097/00000542-198609001-00206 |
0.305 |
|
| 1986 |
de Leede L, de Boer A, Pörtzgen E, Feijen J, Breimer D. Rate-controlled rectal drug delivery in man with a hydrogel preparation Journal of Controlled Release. 4: 17-24. DOI: 10.1016/0168-3659(86)90029-5 |
0.328 |
|
| 1985 |
Teunissen MW, Wahlén A, Vinnars E, Breimer DD. Influence of alaproclate on antipyrine metabolite formation in man. European Journal of Clinical Pharmacology. 27: 447-52. PMID 6519152 DOI: 10.1007/Bf00549593 |
0.388 |
|
| 1985 |
Teunissen MW, Spoelstra P, Koch CW, Weeda B, van Duyn W, Janssens AR, Breimer DD. Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis. British Journal of Clinical Pharmacology. 18: 707-15. PMID 6508980 DOI: 10.1111/J.1365-2125.1984.Tb02533.X |
0.315 |
|
| 1985 |
Teunissen MW, Bakker W, Meerburg-Van der Torren JE, Breimer DD. Influence of rifampicin treatment on antipyrine clearance and metabolite formation in patients with tuberculosis. British Journal of Clinical Pharmacology. 18: 701-6. PMID 6508979 DOI: 10.1111/J.1365-2125.1984.Tb02532.X |
0.343 |
|
| 1985 |
Teunissen MW, Kampf D, Roots I, Vermeulen NP, Breimer DD. Antipyrine metabolite formation and excretion in patients with chronic renal failure. European Journal of Clinical Pharmacology. 28: 589-95. PMID 4043202 DOI: 10.1007/Bf00544072 |
0.559 |
|
| 1985 |
Teunissen MW, Brorens IO, Geerlings JM, Breimer DD. Dose-dependent elimination of theophylline in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 15: 165-71. PMID 4002738 DOI: 10.3109/00498258509045346 |
0.342 |
|
| 1985 |
Breimer DD. Research in the Division of Pharmacology. Pharmaceutisch Weekblad. Scientific Edition. 7: 63-6. PMID 4000900 DOI: 10.1007/Bf02106129 |
0.367 |
|
| 1985 |
Kleinbloesem CH, Brummelen Pv, Harten Jv, Danhof M, Breimer DD. Nifedipine: Influence of renal function on pharmacokinetic/hemodynamic relationship Clinical Pharmacology & Therapeutics. 37: 563-574. PMID 3987180 DOI: 10.1038/Clpt.1985.89 |
0.331 |
|
| 1985 |
van der Graaff M, Hofman PH, Breimer DD, Vermeulen NP, Knabe J, Schamber L. Selected ion monitoring analysis of pseudoracemic hexobarbital and its major metabolites in blood and urine of rats. Biomedical Mass Spectrometry. 12: 464-9. PMID 2932174 DOI: 10.1002/Bms.1200120904 |
0.546 |
|
| 1985 |
Van der Graaff M, Vermeulen NP, Breimer DD. Route- and dose-dependent pharmacokinetics of hexobarbitone in the rat: a re-evaluation of the use of sleeping times in metabolic studies. The Journal of Pharmacy and Pharmacology. 37: 550-4. PMID 2864415 DOI: 10.1111/J.2042-7158.1985.Tb03065.X |
0.549 |
|
| 1985 |
Breimer D, de Boer A, de Leede L. Rate controlled rectal drug delivery in man Journal of Controlled Release. 2: 39-46. DOI: 10.1016/0168-3659(85)90031-8 |
0.346 |
|
| 1985 |
Teunissen MWE, Kleinbloesem CH, de Leede LGJ, Breimer DD. Influence of cimetidine on steady state concentration and metabolite formation from antipyrine infused with a rectal osmotic mini pump European Journal of Clinical Pharmacology. 28: 681-684. DOI: 10.1007/Bf00607915 |
0.391 |
|
| 1984 |
Kleinbloesem CH, Van Harten J, Van Brummelen P, Breimer DD. Liquid chromatographic determination of nifedipine in plasma and of its main metabolite in urine. Journal of Chromatography. 308: 209-16. PMID 6746815 DOI: 10.1016/S0021-9673(01)87547-6 |
0.316 |
|
| 1984 |
van den Broek J, ten Wolde-Kraamwinkel HC, Kleinbloesem CH, Breimer DD. Effect of rifampicin treatment on in vitro drug-metabolizing activities in the pig. Biochemical Pharmacology. 33: 325-7. PMID 6704154 DOI: 10.1016/0006-2952(84)90492-1 |
0.312 |
|
| 1984 |
de Boer AG, Breimer DD, Gubbens-Stibbe JM, Bosma A. First-pass elimination of salicylamide in man following oral and rectal administration. Biopharmaceutics & Drug Disposition. 4: 321-30. PMID 6689276 DOI: 10.1002/Bdd.2510040404 |
0.382 |
|
| 1984 |
Jochemsen R, Van Rijn PA, Hazelzet TG, Breimer DD. Assay of midazolam and brotizolam in plasma by a gas chromatographic and a radioreceptor technique. Pharmaceutisch Weekblad. Scientific Edition. 5: 308-12. PMID 6664823 DOI: 10.1007/Bf02074860 |
0.37 |
|
| 1984 |
Jochemsen R, Joeres RP, Wesselman JG, Richter E, Breimer DD. Pharmacokinetics of oral brotizolam in patients with liver cirrhosis. British Journal of Clinical Pharmacology. 315S-322S. PMID 6661377 DOI: 10.1111/J.1365-2125.1983.Tb02306.X |
0.349 |
|
| 1984 |
Kleinbloesem CH, van Brummelen P, Faber H, Danhof M, Vermeulen NP, Breimer DD. Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man. Biochemical Pharmacology. 33: 3721-4. PMID 6508829 |
0.41 |
|
| 1984 |
van der Graaff M, Vermeulen NP, Joeres RP, Breimer DD. Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt. Pharmacology. 29: 99-109. PMID 6473507 DOI: 10.1159/000137998 |
0.577 |
|
| 1984 |
Jansen M, Baars AJ, Breimer DD. Cytosolic glutathione S-transferases in Drosophila melanogaster. Biochemical Pharmacology. 33: 3655-9. PMID 6439209 DOI: 10.1016/0006-2952(84)90153-9 |
0.315 |
|
| 1984 |
Breimer DD. Rationale for rate-controlled drug delivery of cardiovascular drugs by the transdermal route. American Heart Journal. 108: 196-200. PMID 6428206 DOI: 10.1016/0002-8703(84)90575-1 |
0.323 |
|
| 1984 |
de Leede LGJ, Hug CC, de Lange S, de Boer AG, Breimer DD. Rectal and intravenous propranolol infusion to steady state: Kinetics and β-receptor blockade Clinical Pharmacology and Therapeutics. 35: 148-155. PMID 6319066 DOI: 10.1038/Clpt.1984.20 |
0.378 |
|
| 1983 |
Jochemsen R, Hogendoorn JJ, Dingemanse J, Hermans J, Boeijinga JK, Breimer DD. Pharmacokinetics and bioavailability of intravenous, oral, and rectal nitrazepam in humans. Journal of Pharmacokinetics and Biopharmaceutics. 10: 231-45. PMID 7175697 DOI: 10.1007/Bf01059259 |
0.384 |
|
| 1983 |
Vermeulen NP, Danhof M, Setiawan I, Breimer DD. Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 226: 201-5. PMID 6864540 |
0.544 |
|
| 1983 |
Vermeulen NP, Rietveld CT, Breimer DD. Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration. British Journal of Clinical Pharmacology. 15: 459-64. PMID 6849782 |
0.517 |
|
| 1983 |
Zeng YL, Ten Wolde-Kraamwinkel HC, Baars AJ, Breimer DD. The influence of L-4-oxalysine on carbon tetrachloride-induced changes in drug-metabolizing enzyme activity of mouse liver. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 12: 463-6. PMID 6815904 DOI: 10.3109/00498258209052488 |
0.306 |
|
| 1983 |
Teunissen MW, Meerburg-van der Torren JE, Vermeulen NP, Breimer DD. Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4,4'-dihydroxyantipyrine. Journal of Chromatography. 278: 367-78. PMID 6668316 |
0.503 |
|
| 1983 |
Teunissen MW, Van Graft M, Vermeulen NP, Breimer DD. Influence of allylisopropylacetamide and phenobarbital treatment on in vivo antipyrine metabolite formation in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 497-502. PMID 6649682 DOI: 10.3109/00498258309052289 |
0.581 |
|
| 1983 |
van der Graaff M, Vermeulen NP, Joeres RP, Vlietstra T, Breimer DD. Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats. The Journal of Pharmacology and Experimental Therapeutics. 227: 459-65. PMID 6631725 |
0.509 |
|
| 1983 |
Breimer DD. Interindividual variations in drug disposition. Clinical implications and methods of investigation. Clinical Pharmacokinetics. 8: 371-7. PMID 6627809 DOI: 10.2165/00003088-198308050-00001 |
0.312 |
|
| 1983 |
Teunissen MW, Joeres RP, Vermeulen NP, Breimer DD. Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 223-31. PMID 6624137 DOI: 10.3109/00498258309052258 |
0.583 |
|
| 1983 |
van der Graaff M, Vermeulen NP, Joeres RP, Breimer DD. Disposition of hexobarbital enantiomers in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 11: 489-93. PMID 6138236 |
0.5 |
|
| 1983 |
van der Graaff M, Vermeulen NP, Langendijk PN, Breimer DD. Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies. The Journal of Pharmacology and Experimental Therapeutics. 225: 747-51. PMID 6134816 |
0.549 |
|
| 1983 |
Jochemsen R, Boxtel CJv, Hermans J, Breimer DD. Kinetics of five benzodiazepine hypnotics in healthy subjects Clinical Pharmacology & Therapeutics. 34: 42-47. PMID 6134599 DOI: 10.1038/Clpt.1983.126 |
0.357 |
|
| 1983 |
Kleinbloesem CH, van Brummelen P, van de Linde JA, Breimer DD, Kerremans ALM, Cremers HJ, Rodrigues de Miranda JF, van Ginneken CAM, Gribnau FWJ, Schols M, Mooy J, van Hooff M, van Baak MA, Rahn KH, Soeterboek AM, et al. Abstracts of papers Pharmaceutisch Weekblad. 5: 191-196. DOI: 10.1007/BF01961482 |
0.445 |
|
| 1982 |
Danhof M, van Zuilen A, Boeijinga JK, Breimer DD. Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time. European Journal of Clinical Pharmacology. 21: 433-41. PMID 7075648 DOI: 10.1007/Bf00542332 |
0.4 |
|
| 1982 |
Danhof M, Teunissen MW, Breimer DD. 3-Hydroxymethyl antipyrine excretion in urine after an oral dose of antipyrine. A reconsideration of previously published data and synthesis of a pure reference substance. Pharmacology. 24: 181-4. PMID 7071130 DOI: 10.1159/000137594 |
0.309 |
|
| 1982 |
de Boer AG, Moolenaar F, de Leede LG, Breimer DD. Rectal drug administration: clinical pharmacokinetic considerations. Clinical Pharmacokinetics. 7: 285-311. PMID 6126289 DOI: 10.2165/00003088-198207040-00002 |
0.361 |
|
| 1981 |
van Bladeren PJ, Breimer DD, van Huijgevoort JA, Vermeulen NP, van der Gen A. The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo. Biochemical Pharmacology. 30: 2499-502. PMID 21043256 |
0.447 |
|
| 1981 |
Heusler H, Epping J, Heusler S, Richter E, Vermeulen NP, Breimer DD. Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry. Journal of Chromatography. 226: 403-12. PMID 7320169 |
0.518 |
|
| 1981 |
Danhof M, Idle JR, Teunissen MW, Sloan TP, Breimer DD, Smith RL. Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation. Pharmacology. 22: 349-58. PMID 7267701 DOI: 10.1159/000137515 |
0.374 |
|
| 1981 |
de Leede LG, de Boer AG, Breimer DD. Rectal infusion of the model drug antipyrine with an osmotic delivery system. Biopharmaceutics & Drug Disposition. 2: 131-6. PMID 7248477 DOI: 10.1002/Bdd.2510020205 |
0.35 |
|
| 1981 |
van Bladeren PJ, Hoogeterp JJ, Breimer DD, van der Gen A. The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat. Biochemical Pharmacology. 30: 2983-7. PMID 7032529 DOI: 10.1016/0006-2952(81)90263-X |
0.35 |
|
| 1981 |
Vermeulen NP, Breimer DD, Holthuis J, Mol C, Bakker BH, van der Gen A. The metabolic fate of 1',2'-epoxyhexobarbital in the rat. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 11: 547-57. PMID 7029928 DOI: 10.3109/00498258109045866 |
0.529 |
|
| 1981 |
Baars AJ, Zijlstra JA, Jansen M, Vogel E, Breimer DD. Biotransformation and spectral interaction of xenobiotics with subcellular fractions from Drosophila melanogaster. Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement. 4: 54-8. PMID 6776938 DOI: 10.1007/978-3-642-67729-8_11 |
0.321 |
|
| 1981 |
Boer AGd, Gubbens‐Stibbe JM, Breimer DD. Avoidance of first pass elimination of propranolol after rectal administration to rats. Journal of Pharmacy and Pharmacology. 33: 50-51. PMID 6114157 DOI: 10.1111/J.2042-7158.1981.Tb13704.X |
0.314 |
|
| 1981 |
Jochemsen R, Breimer DD. Assay of triazolam in plasma by capillary gas chromatography. Journal of Chromatography. 223: 438-44. PMID 6114106 DOI: 10.1016/S0378-4347(00)80119-X |
0.306 |
|
| 1981 |
Vermeulen NP, Bakker BH, Eylers D, Breimer DD. The epoxide-diol pathway in the metabolism of vinylbital in rat and man. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 10: 159-68. PMID 6110286 DOI: 10.3109/00498258009033742 |
0.51 |
|
| 1980 |
de Boer AG, Breimer DD, Pronk J, Gubbens-Stibbe JM. Rectal bioavailability of lidocaine in rats: absence of significant first-pass elimination. Journal of Pharmaceutical Sciences. 69: 804-7. PMID 7391945 DOI: 10.1002/Jps.2600690716 |
0.329 |
|
| 1980 |
Richter E, Breimer DD, Zilly W. Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents. European Journal of Clinical Pharmacology. 17: 197-202. PMID 7363932 DOI: 10.1007/Bf00561900 |
0.355 |
|
| 1980 |
van Bladeren PJ, Breimer DD, Rotteveel-Smijs GM, Mohn GR. Mutagenic activation of dibromomethane and diiodomethane by mammalian microsomes and glutathione S-transferases. Mutation Research. 74: 341-6. PMID 7010125 DOI: 10.1016/0165-1161(80)90192-2 |
0.305 |
|
| 1980 |
van Bladeren PJ, Breimer DD, Rotteveel-Smijs GM, de Jong RA, Buijs W, van der Gen A, Mohn GR. The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane. Biochemical Pharmacology. 29: 2975-82. PMID 7006609 DOI: 10.1016/0006-2952(80)90047-7 |
0.349 |
|
| 1980 |
Baars AJ, Blijleven WG, Mohn GR, Natarajan AT, Breimer DD. Preliminary studies on the ability of Drosophila microsomal preparations to activate mutagens and carcinogens. Mutation Research. 72: 257-64. PMID 6777691 DOI: 10.1016/0027-5107(80)90040-8 |
0.303 |
|
| 1980 |
Vermeulen NP, Teunissen MW, Breimer DD. Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration. British Journal of Clinical Pharmacology. 8: 459-63. PMID 508551 DOI: 10.1111/J.1365-2125.1979.TB01026.X |
0.528 |
|
| 1980 |
Breimer DD. Pharmacokinetics and metabolism of various benzodiazepines used as hypnotics. British Journal of Clinical Pharmacology. 8: 7S-13S. PMID 41545 DOI: 10.1111/J.1365-2125.1979.Tb00449.X |
0.335 |
|
| 1980 |
De Boer AG, Breimer DD, Gubbens-Stibbe JM. Assay of propranolol in human and rat plasma by capillary gas chromatography with nitrogen selective detection Pharmaceutisch Weekblad. 2: 1105-1109. DOI: 10.1007/Bf02273266 |
0.342 |
|
| 1979 |
Baars AJ, Jansen M, Breimer DD. The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. Biochemical Pharmacology. 27: 2487-97. PMID 728202 DOI: 10.1016/0006-2952(78)90314-3 |
0.316 |
|
| 1979 |
Boer AGd, Breimer DD, Mattie H, Pronk J, Gubbens-Stibbe JM. Rectal Bioavailability of Lidocaine in Man: Partial Avoidance of "First-Pass" Metabolism Clinical Pharmacology & Therapeutics. 26: 701-709. PMID 498711 DOI: 10.1002/Cpt1979266701 |
0.411 |
|
| 1979 |
Vermeulen NP, Bakker BH, Schultink J, van der Gen A, Breimer DD. The epoxide-diol pathway in the metabolism of hexobarbital in rat and man. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 9: 289-99. PMID 494660 DOI: 10.3109/00498257909038732 |
0.462 |
|
| 1978 |
Vermeulen NP, Teunissen MW, Breimer DD. Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography. 157: 133-40. PMID 701438 DOI: 10.1016/S0021-9673(00)92329-X |
0.501 |
|
| 1978 |
Vermeulen NP, van Bladeren PJ, Breimer DD, van der Gen A. Hexobarbital-1',2'-epoxide: a possible intermediate in the metabolism of hexobarbital. Biochemical Pharmacology. 27: 135-8. PMID 619900 DOI: 10.1016/0006-2952(78)90274-5 |
0.439 |
|
| 1977 |
Vermeulen NP, de Roode D, Breimer DD. Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine. Journal of Chromatography. 137: 333-42. PMID 881457 DOI: 10.1016/S0021-9673(00)81356-4 |
0.488 |
|
| 1977 |
Zilly W, Breimer DD, Richter E. Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. European Journal of Clinical Pharmacology. 11: 287-93. PMID 862650 DOI: 10.1007/Bf00607679 |
0.354 |
|
| 1977 |
Breimer DD. Pharmacokinetics of methohexitone following intravenous infusion in humans. British Journal of Anaesthesia. 48: 643-9. PMID 797396 DOI: 10.1093/BJA/48.7.643 |
0.313 |
|
| 1977 |
Zilly W, Breimer DD, Richter E. Pharmacokinetic interactions with rifampicin. Clinical Pharmacokinetics. 2: 61-70. PMID 140033 DOI: 10.2165/00003088-197702010-00005 |
0.357 |
|
| 1977 |
Breimer DD. Clinical pharmacokinetics of hypnotics. Clinical Pharmacokinetics. 2: 93-109. PMID 16715 DOI: 10.2165/00003088-197702020-00002 |
0.373 |
|
| 1976 |
Breimer DD, Winten MA. Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration. European Journal of Clinical Pharmacology. 9: 443-50. PMID 989475 DOI: 10.1007/Bf00606563 |
0.334 |
|
| 1976 |
Breimer DD, de Boer AG. Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man. European Journal of Clinical Pharmacology. 9: 169-78. PMID 9299 DOI: 10.1007/Bf00614014 |
0.402 |
|
| 1976 |
Breimer DD. Pharmacokinetics of butobarbital after single and multiple oral doses in man European Journal of Clinical Pharmacology. 10: 263-271. DOI: 10.1007/Bf00558339 |
0.376 |
|
| 1975 |
Breimer DD, Honhoff C, Zilly W, Richter E, van Rossum JM. Pharmocokinetics of hexobarbital in man after intravenous infusion. Journal of Pharmacokinetics and Biopharmaceutics. 3: 1-11. PMID 1127574 DOI: 10.1007/BF01066591 |
0.561 |
|
| 1974 |
Breimer DD, van Rossum JM. Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver. European Journal of Pharmacology. 26: 321-30. PMID 4853606 DOI: 10.1016/0014-2999(74)90243-X |
0.518 |
|
| 1974 |
Breimer DD, Van Rossum JM. Rapid and sensitive gas chromatographic determination of hexobarbital in plasma of man using a nitrogen detector. Journal of Chromatography. 88: 235-43. PMID 4814347 DOI: 10.1016/S0021-9673(00)83147-7 |
0.519 |
|
| 1974 |
Breimer DD, Ketelaars HCJ, Van Rossum JM. Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysis Journal of Chromatography A. 88: 55-63. DOI: 10.1016/S0021-9673(01)91772-8 |
0.502 |
|
| 1973 |
Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Gas chromatography of cannabinoids. Gas chromatographic behaviour of cis- and trans- tetrahydrocannabinol and isotetrahydrocannabinol. Journal of Chromatography. 79: 81-90. PMID 4708862 DOI: 10.1016/S0021-9673(01)85276-6 |
0.488 |
|
| 1973 |
Breimer DD, van Rossum JM. Letter: Pharmacokinetics of (+)-, (-)- and (plus or minus)-hexobarbitone in man after oral administration. The Journal of Pharmacy and Pharmacology. 25: 762-4. PMID 4148519 DOI: 10.1111/j.2042-7158.1973.tb10066.x |
0.54 |
|
| 1972 |
de Zeeuw RA, Wijsbeek J, Breimer DD, Vree TB, van Ginneken CA, van Rossum JM. Cannabinoids with a propyl side chain in cannabis: occurrence and chromatographic behavior. Science (New York, N.Y.). 175: 778-9. PMID 5057817 |
0.482 |
|
| 1972 |
Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Gas chromatography of cannabis constituents and their synthetic derivatives. Journal of Chromatography. 74: 209-24. PMID 4645669 |
0.486 |
|
| 1972 |
Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Identification of cannabicyclol with a pentyl or propyl side-chain by means of combined gas chromatography-mass spectrometry. Journal of Chromatography. 74: 124-7. PMID 4635939 |
0.484 |
|
| 1972 |
Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Identification in hashish of tetrahydrocannabinol, cannabidiol and cannabinol analogues with a methyl side-chain. The Journal of Pharmacy and Pharmacology. 24: 7-12. PMID 4401327 |
0.449 |
|
| 1971 |
Vree TB, Breimer DD, van Ginneken CA, van Rossum JM, de Zeeuw RA, Witte AH. Identification of cannabivarins in hashish by a new method of combined gas chromatography-mass-spectrometry. Clinica Chimica Acta; International Journal of Clinical Chemistry. 34: 365-72. PMID 5113572 |
0.48 |
|
| 1971 |
Vree TB, van Rossum JM, Breimer DD, van Ginneken GA, van Kordelaar JM. Gas-liquid chromatography in pharmacology and toxicology. Pharmacokinetic analysis limited by the sensitivity of the analytical technique. Clinica Chimica Acta; International Journal of Clinical Chemistry. 34: 311-9. PMID 5113568 |
0.504 |
|
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