Rainer Spanagel, Ph.D - Publications

Affiliations: 
Psychopharmacology Central Institute of Mental Health, Mannheim, Mannheim, Baden-Württemberg, Germany 
Area:
Drug addiction, alcohol, behaviour
Website:
http://www.zi-mannheim.de/index.php?id=888&type=0

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bilbao A, Neuhofer D, Sepers M, Wei SP, Eisenhardt M, Hertle S, Lassalle O, Ramos-Uriarte A, Puente N, Lerner R, Grandes P, Lutz B, Manzoni OJ, Spanagel R. Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. Iscience. 23: 100951. PMID 32179475 DOI: 10.1016/J.Isci.2020.100951  0.382
2019 Heinz A, Kiefer F, Smolka MN, Endrass T, Beste C, Beck A, Liu S, Genauck A, Romund L, Banaschewski T, Bermpohl F, Deserno L, Dolan RJ, Durstewitz D, Ebner-Priemer U, ... ... Spanagel R, et al. Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions. Addiction Biology. e12866. PMID 31859437 DOI: 10.1111/Adb.12866  0.306
2019 Bernardi RE, Olevska A, Morella I, Fasano S, Santos E, Brambilla R, Spanagel R. The inhibition of RasGRF2, but not RasGRF1, alters cocaine reward in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31182637 DOI: 10.1523/Jneurosci.1120-18.2019  0.376
2019 Foo JC, Vengeliene V, Noori HR, Yamaguchi I, Morita K, Nakamura T, Yamamoto Y, Spanagel R. Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene. Frontiers in Pharmacology. 10: 471. PMID 31133855 DOI: 10.3389/Fphar.2019.00471  0.346
2018 van den Brink W, Addolorato G, Aubin HJ, Benyamina A, Caputo F, Dematteis M, Gual A, Lesch OM, Mann K, Maremmani I, Nutt D, Paille F, Perney P, Rehm J, Reynaud M, ... ... Spanagel R, et al. Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level. Addiction Biology. 23: 969-986. PMID 30043457 DOI: 10.1111/Adb.12645  0.326
2018 Cannella N, Oliveira AMM, Hemstedt T, Lissek T, Buechler E, Bading H, Spanagel R. Dnmt3a2 in the Nucleus Accumbens Shell Is Required for Reinstatement of Cocaine Seeking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 38: 7516-7528. PMID 30030395 DOI: 10.1523/Jneurosci.0600-18.2018  0.396
2018 Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I. Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system. Journal of Neurochemistry. PMID 29747224 DOI: 10.1111/Jnc.14460  0.334
2018 Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson AC. Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior. Psychopharmacology. 235: 1821-1833. PMID 29700576 DOI: 10.1007/S00213-018-4908-6  0.347
2018 Vengeliene V, Rossmanith M, Takahashi TT, Alberati D, Behl B, Bespalov A, Spanagel R. Targeting Glycine Reuptake in Alcohol Seeking and Relapse. The Journal of Pharmacology and Experimental Therapeutics. PMID 29367277 DOI: 10.1124/Jpet.117.244822  0.363
2017 Bernardi RE, Broccoli L, Hirth N, Justice NJ, Deussing JM, Hansson AC, Spanagel R. Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior. Frontiers in Behavioral Neuroscience. 11: 221. PMID 29180955 DOI: 10.3389/Fnbeh.2017.00221  0.407
2017 Hansson AC, Koopmann A, Uhrig S, Bühler S, Domi E, Kiessling E, Ciccocioppo R, Froemke RC, Grinevich V, Kiefer F, Sommer WH, Vollstädt-Klein S, Spanagel R. Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29090683 DOI: 10.1038/Npp.2017.257  0.361
2017 Foo JC, Noori HR, Yamaguchi I, Vengeliene V, Cosa-Linan A, Nakamura T, Morita K, Spanagel R, Yamamoto Y. Dynamical state transitions into addictive behaviour and their early-warning signals. Proceedings. Biological Sciences. 284. PMID 28768888 DOI: 10.1098/Rspb.2017.0882  0.313
2017 Treutlein J, Frank J, Streit F, Reinbold CS, Juraeva D, Degenhardt F, Rietschel L, Witt SH, Forstner AJ, Ridinger M, Strohmaier J, Wodarz N, Dukal H, Foo JC, Hoffmann P, ... ... Spanagel R, et al. Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. Genes. 8. PMID 28714907 DOI: 10.3390/Genes8070183  0.307
2017 Vengeliene V, Bespalov A, Roßmanith M, Horschitz S, Berger S, Relo AL, Noori HR, Schneider P, Enkel T, Bartsch D, Schneider M, Behl B, Hansson AC, Schloss P, Spanagel R. Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene. Disease Models & Mechanisms. PMID 28167616 DOI: 10.1242/Dmm.027623  0.326
2016 Uhrig S, Vandael D, Marcantoni A, Dedic N, Bilbao A, Vogt MA, Hirth N, Broccoli L, Bernardi RE, Schönig K, Gass P, Bartsch D, Spanagel R, Deussing JM, Sommer WH, et al. Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27905406 DOI: 10.1038/Npp.2016.266  0.352
2016 Luís C, Cannella N, Spanagel R, Köhr G. Persistent strengthening of the prefrontal cortex - nucleus accumbens pathway during incubation of cocaine-seeking behavior. Neurobiology of Learning and Memory. PMID 27720809 DOI: 10.1016/J.Nlm.2016.10.003  0.401
2016 Papale A, Morella IM, Indrigo MT, Eugene Bernardi R, Marrone L, Marchisella F, Brancale A, Spanagel R, Brambilla R, Fasano S. Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors. Elife. 5. PMID 27557444 DOI: 10.7554/Elife.17111  0.36
2016 Hermann D, Hirth N, Reimold M, Batra A, Smolka MN, Hoffmann S, Kiefer F, Noori HR, Sommer WH, Reischl G, la Fougère C, Mann K, Spanagel R, Hansson AC. Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27510425 DOI: 10.1038/Npp.2016.145  0.326
2016 Hadar R, Vengeliene V, Hlusicke EB, Canals S, Noori HR, Wieske F, Rummel J, Harnack D, Heinz A, Spanagel R, Winter C. Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens Translational Psychiatry. 6: 1-9. PMID 27327255 DOI: 10.1038/Tp.2016.100  0.334
2016 Heilig M, Sommer WH, Spanagel R. The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research. Current Topics in Behavioral Neurosciences. PMID 27240677 DOI: 10.1007/7854_2015_5006  0.346
2016 Hirth N, Meinhardt MW, Noori HR, Salgado H, Torres-Ramirez O, Uhrig S, Broccoli L, Vengeliene V, Roßmanith M, Perreau-Lenz S, Köhr G, Sommer WH, Spanagel R, Hansson AC. Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903621 DOI: 10.1073/Pnas.1506012113  0.368
2016 Papale A, Morella IM, Indrigo MT, Bernardi RE, Marrone L, Marchisella F, Brancale A, Spanagel R, Brambilla R, Fasano S. Author response: Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors Elife. DOI: 10.7554/Elife.17111.021  0.338
2015 Stacey D, Lourdusamy A, Ruggeri B, Maroteaux M, Jia T, Cattrell A, Nymberg C, Banaschewski T, Bhattacharyya S, Band H, Barker G, Bokde A, Buchel C, Carvalho F, Conrod P, ... ... Spanagel R, et al. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males. Journal of Psychiatry & Neuroscience : Jpn. 41: 150138. PMID 26679926 DOI: 10.1503/Jpn.150138  0.354
2015 Eisenhardt M, Leixner S, Luján R, Spanagel R, Bilbao A. Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15523-38. PMID 26609150 DOI: 10.1523/Jneurosci.2970-15.2015  0.399
2015 Eisenhardt M, Leixner S, Spanagel R, Bilbao A. Quantification of alcohol drinking patterns in mice. Addiction Biology. PMID 26515884 DOI: 10.1111/Adb.12325  0.334
2015 Bernardi RE, Broccoli L, Spanagel R, Hansson AC. Sex differences in dopamine binding and modafinil conditioned place preference in mice. Drug and Alcohol Dependence. 155: 37-44. PMID 26342627 DOI: 10.1016/J.Drugalcdep.2015.08.016  0.326
2015 Pfarr S, Meinhardt MW, Klee ML, Hansson AC, Vengeliene V, Schönig K, Bartsch D, Hope BT, Spanagel R, Sommer WH. Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10750-61. PMID 26224858 DOI: 10.1093/Alcalc/Agv080.67  0.347
2015 Vengeliene V, Moeller A, Meinhardt MW, Beardsley PM, Sommer WH, Spanagel R, Bespalov A. The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26216521 DOI: 10.1038/Npp.2015.225  0.361
2015 Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Büchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, ... ... Spanagel R, et al. Rsu1 regulates ethanol consumption in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America. 112: E4085-93. PMID 26170296 DOI: 10.1073/Pnas.1417222112  0.305
2015 Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C, Conrod PJ, ... ... Spanagel R, et al. Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. The American Journal of Psychiatry. 172: 543-52. PMID 25982659 DOI: 10.1176/Appi.Ajp.2014.14030382  0.3
2015 Bach P, Vollsta Dt-Klein S, Kirsch M, Hoffmann S, Jorde A, Frank J, Charlet K, Beck A, Heinz A, Walter H, Sommer WH, Spanagel R, Rietschel M, Kiefer F. Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: A functional imaging study in alcohol dependent subjects. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 25937240 DOI: 10.1016/J.Euroneuro.2015.04.013  0.35
2015 Eisenhardt M, Hansson AC, Spanagel R, Bilbao A. Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling. Alcoholism, Clinical and Experimental Research. 39: 752-62. PMID 25833034 DOI: 10.1111/Acer.12686  0.343
2015 Kiefer F, Kirsch M, Bach P, Hoffmann S, Reinhard I, Jorde A, von der Goltz C, Spanagel R, Mann K, Loeber S, Vollstädt-Klein S. Effects of D-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial. Psychopharmacology. 232: 2353-62. PMID 25697860 DOI: 10.1007/S00213-015-3882-5  0.347
2015 Bilbao A, Robinson JE, Heilig M, Malanga CJ, Spanagel R, Sommer WH, Thorsell A. A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. Biological Psychiatry. 77: 850-8. PMID 25442002 DOI: 10.1016/J.Biopsych.2014.08.021  0.335
2015 Juraeva D, Treutlein J, Scholz H, Frank J, Degenhardt F, Cichon S, Ridinger M, Mattheisen M, Witt SH, Lang M, Sommer WH, Hoffmann P, Herms S, Wodarz N, Soyka M, ... ... Spanagel R, et al. XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 361-71. PMID 25035082 DOI: 10.1038/Npp.2014.178  0.32
2015 Broccoli L, Jüngling K, Borroto-Escuela DO, Spanagel R, Sommer WH, Pape HC, Fuxe K, Deussing JM, Hansson AC. SY28-4CROSS-TALK OF CORTICOTROPIN RELEASING HORMONE RECEPTOR SUBTYPE 1 WITH DOPAMINE D1 RECEPTOR: FUNCTIONAL RELEVANCE IN ALCOHOL DEPENDENCE Alcohol and Alcoholism. 50: i31.4-i31. DOI: 10.1093/Alcalc/Agv076.116  0.345
2014 Bernardi RE, Spanagel R. A two-injection protocol for nicotine sensitization. Behavioural Brain Research. 275: 11-4. PMID 25192633 DOI: 10.1016/J.Bbr.2014.08.048  0.308
2014 Bernardi RE, Spanagel R. Enhanced extinction of contextual fear conditioning in ClockΔ19 mutant mice. Behavioral Neuroscience. 128: 468-73. PMID 24865659 DOI: 10.1037/A0037020  0.318
2014 Vengeliene V, Bilbao A, Spanagel R. The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice. Alcohol (Fayetteville, N.Y.). 48: 313-20. PMID 24811155 DOI: 10.1016/J.Alcohol.2014.03.002  0.348
2014 Spanagel R, Noori HR, Heilig M. Stress and alcohol interactions: animal studies and clinical significance. Trends in Neurosciences. 37: 219-27. PMID 24636458 DOI: 10.1016/J.Tins.2014.02.006  0.322
2014 Bernardi RE, Spanagel R. Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders. Behavioural Brain Research. 264: 143-50. PMID 24508239 DOI: 10.1016/J.Bbr.2014.01.046  0.309
2014 Halbout B, Bernardi RE, Hansson AC, Spanagel R. Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1781-90. PMID 24478360 DOI: 10.1523/Jneurosci.1076-13.2014  0.774
2014 Jorde A, Bach P, Witt SH, Becker K, Reinhard I, Vollstädt-Klein S, Kirsch M, Hermann D, Charlet K, Beck A, Wimmer L, Frank J, Treutlein J, Spanagel R, Mann K, et al. Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. Biological Psychiatry. 75: 790-7. PMID 24314346 DOI: 10.1016/J.Biopsych.2013.10.020  0.331
2014 Vengeliene V, Bessiere B, Pype J, Spanagel R. The effects of xenon and nitrous oxide gases on alcohol relapse. Alcoholism, Clinical and Experimental Research. 38: 557-63. PMID 24118055 DOI: 10.1111/Acer.12264  0.347
2014 Spanagel R, Vengeliene V, Jandeleit B, Fischer WN, Grindstaff K, Zhang X, Gallop MA, Krstew EV, Lawrence AJ, Kiefer F. Acamprosate produces its anti-relapse effects via calcium. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 783-91. PMID 24081303 DOI: 10.1038/Npp.2013.264  0.343
2014 Olevska A, Bernardi R, Brambilla R, Spanagel R. P.6.c.009 The role of ras guanine nucleotide-releasing factor 1 (ras-GRF1) in cocaine self-administration European Neuropsychopharmacology. 24: S679-S680. DOI: 10.1016/S0924-977X(14)71095-8  0.301
2014 Pfarr S, Meinhardt MW, Klee ML, Schönig K, Vengeliene V, Hope BT, Bartsch D, Spanagel R, Sommer WH. P.6.a.016 Losing control: excessive alcohol seeking after selective inactivation of cue-responsive neurons in the infralimbic cortex European Neuropsychopharmacology. 24. DOI: 10.1016/S0924-977X(14)71065-X  0.316
2014 Olevska A, Bernardi R, Brambilla R, Spanagel R. P.2.019 The role of Ras guanine nucleotide-releasing factor 1 in cocaine self-administration European Neuropsychopharmacology. 24: S46-S47. DOI: 10.1016/S0924-977X(14)70052-5  0.327
2013 Spanagel R, Durstewitz D, Hansson A, Heinz A, Kiefer F, Köhr G, Matthäus F, Nöthen MM, Noori HR, Obermayer K, Rietschel M, Schloss P, Scholz H, Schumann G, Smolka M, et al. A systems medicine research approach for studying alcohol addiction. Addiction Biology. 18: 883-96. PMID 24283978 DOI: 10.1111/Adb.12109  0.318
2013 Bernardi RE, Spanagel R. The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine. Drug and Alcohol Dependence. 133: 733-9. PMID 24054990 DOI: 10.1016/J.Drugalcdep.2013.08.024  0.318
2013 Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology. 229: 539-54. PMID 23995381 DOI: 10.1007/S00213-013-3226-2  0.35
2013 Cannella N, Halbout B, Uhrig S, Evrard L, Corsi M, Corti C, Deroche-Gamonet V, Hansson AC, Spanagel R. The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2048-56. PMID 23624743 DOI: 10.1038/Npp.2013.106  0.778
2013 Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher KU, Spanagel R, Sommer WH. Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2794-806. PMID 23407939 DOI: 10.1523/Jneurosci.4062-12.2013  0.373
2013 Bilbao A, Blanco E, Luque-Rojas MJ, Suárez J, Palomino A, Vida M, Araos P, Bermúdez-Silva FJ, Fernández-Espejo E, Spanagel R, Rodríguez de Fonseca F. Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism. Addiction Biology. 18: 78-87. PMID 23163925 DOI: 10.1111/Adb.12006  0.401
2012 Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, ... ... Spanagel R, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proceedings of the National Academy of Sciences of the United States of America. 109: 21128-33. PMID 23223532 DOI: 10.1073/Pnas.1211844110  0.371
2012 Perreau-Lenz S, Vengeliene V, Noori HR, Merlo-Pich EV, Corsi MA, Corti C, Spanagel R. Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2121-31. PMID 22549116 DOI: 10.1038/Npp.2012.62  0.348
2012 Whelan R, Conrod PJ, Poline JB, Lourdusamy A, Banaschewski T, Barker GJ, Bellgrove MA, Büchel C, Byrne M, Cummins TD, Fauth-Bühler M, Flor H, Gallinat J, Heinz A, Ittermann B, ... ... Spanagel R, et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. Nature Neuroscience. 15: 920-5. PMID 22544311 DOI: 10.1038/Nn.3092  0.476
2012 Nees F, Tzschoppe J, Patrick CJ, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Garavan H, Heinz A, Gallinat J, Lathrop M, Mann K, ... ... Spanagel R, et al. Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 986-95. PMID 22113088 DOI: 10.1038/Npp.2011.282  0.337
2012 Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1047-56. PMID 22113086 DOI: 10.1038/Npp.2011.297  0.341
2012 Schneider S, Peters J, Bromberg U, Brassen S, Miedl SF, Banaschewski T, Barker GJ, Conrod P, Flor H, Garavan H, Heinz A, Ittermann B, Lathrop M, Loth E, Mann K, ... ... Spanagel R, et al. Risk taking and the adolescent reward system: a potential common link to substance abuse. The American Journal of Psychiatry. 169: 39-46. PMID 21955931 DOI: 10.1176/Appi.Ajp.2011.11030489  0.306
2012 Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH. Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biological Psychiatry. 71: 1015-21. PMID 21907974 DOI: 10.1016/J.Biopsych.2011.07.034  0.339
2011 Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, Desrivieres S, Clarke TK, Lourdusamy A, Smolka MN, Cichon S, Blomeyer D, Treutlein J, Perreau-Lenz S, Witt S, ... ... Spanagel R, et al. Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. The American Journal of Psychiatry. 168: 1090-8. PMID 21828288 DOI: 10.1176/Appi.Ajp.2011.10111579  0.31
2011 Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Desrivières S, Aliev FA, Khan AA, Amin N, Aulchenko YS, Bakalkin G, Bakker SJ, Balkau B, Beulens JW, ... ... Spanagel R, et al. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America. 108: 7119-24. PMID 21471458 DOI: 10.1073/Pnas.1017288108  0.323
2011 Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M. Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 505-17. PMID 21211107 DOI: 10.1017/S1461145710001562  0.329
2011 Halbout B, Perreau-Lenz S, Dixon CI, Stephens DN, Spanagel R. Per1(Brdm1) mice self-administer cocaine and reinstate cocaine-seeking behaviour following extinction. Behavioural Pharmacology. 22: 76-80. PMID 21127416 DOI: 10.1097/Fbp.0B013E328341E9Ca  0.783
2011 Kiefer F, Witt SH, Frank J, Richter A, Treutlein J, Lemenager T, Nöthen MM, Cichon S, Batra A, Berner M, Wodarz N, Zimmermann US, Spanagel R, Wiedemann K, Smolka MN, et al. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. The Pharmacogenomics Journal. 11: 368-74. PMID 20585342 DOI: 10.1038/Tpj.2010.51  0.317
2010 Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik C, ... ... Spanagel R, et al. The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Molecular Psychiatry. 15: 1128-39. PMID 21102431 DOI: 10.1038/Mp.2010.4  0.471
2010 Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jäger W, Mann K, Matthäus F, Nöthen M, et al. An integrated genome research network for studying the genetics of alcohol addiction. Addiction Biology. 15: 369-79. PMID 21040237 DOI: 10.1111/J.1369-1600.2010.00276.X  0.339
2010 Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, Zhang Y, Shen J, George DT, Hommer D, Heilig M. Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Archives of General Psychiatry. 67: 1069-77. PMID 20921123 DOI: 10.1001/Archgenpsychiatry.2010.125  0.323
2010 Novak M, Halbout B, O'Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D. Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11973-82. PMID 20826661 DOI: 10.1523/Jneurosci.2550-10.2010  0.79
2010 Vengeliene V, Leonardi-Essmann F, Sommer WH, Marston HM, Spanagel R. Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biological Psychiatry. 68: 704-11. PMID 20655511 DOI: 10.1016/J.Biopsych.2010.05.029  0.359
2009 Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Lüscher C. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nature Neuroscience. 12: 1036-41. PMID 19597494 DOI: 10.1038/Nn.2367  0.772
2009 Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, Zill P, Maier W, Moessner R, Gaebel W, Dahmen N, Fehr C, Scherbaum N, Steffens M, Ludwig KU, Frank J, ... ... Spanagel R, et al. Genome-wide association study of alcohol dependence. Archives of General Psychiatry. 66: 773-84. PMID 19581569 DOI: 10.1001/Archgenpsychiatry.2009.83  0.311
2009 Perreau-Lenz S, Zghoul T, de Fonseca FR, Spanagel R, Bilbao A. Circadian regulation of central ethanol sensitivity by the mPer2 gene. Addiction Biology. 14: 253-9. PMID 19523042 DOI: 10.1111/J.1369-1600.2009.00165.X  0.313
2009 Matthäus F, Smith VA, Fogtman A, Sommer WH, Leonardi-Essmann F, Lourdusamy A, Reimers MA, Spanagel R, Gebicke-Haerter PJ. Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats. Pharmacopsychiatry. 42: S118-28. PMID 19434550 DOI: 10.1055/S-0029-1216348  0.317
2009 Halbout B, Bilbao A, Parkitna JR, Schütz G, Spanagel R. P.4.04 Specific deletion of AMPA-R GluR1 subunits in D1 expressing neurons: cocaine-addiction related behavioural consequences European Neuropsychopharmacology. 19. DOI: 10.1016/S0924-977X(09)70094-X  0.758
2008 Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de Fonseca FR, ... ... Spanagel R, et al. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 105: 17549-54. PMID 19001277 DOI: 10.1073/Pnas.0803959105  0.396
2008 Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR, Luján R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron. 59: 497-508. PMID 18701074 DOI: 10.1016/J.Neuron.2008.07.010  0.777
2008 Wiens F, Zitzmann A, Lachance MA, Yegles M, Pragst F, Wurst FM, von Holst D, Guan SL, Spanagel R. Chronic intake of fermented floral nectar by wild treeshrews. Proceedings of the National Academy of Sciences of the United States of America. 105: 10426-31. PMID 18663222 DOI: 10.1073/Pnas.0801628105  0.312
2008 Schumann G, Johann M, Frank J, Preuss U, Dahmen N, Laucht M, Rietschel M, Rujescu D, Lourdusamy A, Clarke TK, Krause K, Dyer A, Depner M, Wellek S, Treutlein J, ... ... Spanagel R, et al. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Archives of General Psychiatry. 65: 826-38. PMID 18606955 DOI: 10.1001/Archpsyc.65.7.826  0.335
2008 Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S, Bilbao A, Hörtnagl H, Baron J, Juranek J, Laube G, Birnbaumer L, Spanagel R, Ahnert-Hilger G. Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3736-46. PMID 18606864 DOI: 10.1096/Fj.08-111245  0.389
2008 Mann K, Kiefer F, Spanagel R, Littleton J. Acamprosate: recent findings and future research directions. Alcoholism, Clinical and Experimental Research. 32: 1105-10. PMID 18540918 DOI: 10.1111/J.1530-0277.2008.00690.X  0.371
2008 Raeder H, Holter SM, Hartmann AM, Spanagel R, Moller HJ, Rujescu D. Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administration. Drug and Alcohol Dependence. 96: 16-21. PMID 18358639 DOI: 10.1016/J.Drugalcdep.2007.12.013  0.34
2008 Vengeliene V, Bilbao A, Molander A, Spanagel R. Neuropharmacology of alcohol addiction. British Journal of Pharmacology. 154: 299-315. PMID 18311194 DOI: 10.1038/Bjp.2008.30  0.335
2008 Frank ST, Krumm B, Spanagel R. Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis. Synapse (New York, N.Y.). 62: 243-52. PMID 18236471 DOI: 10.1002/Syn.20489  0.369
2007 Schneider M, Spanagel R, Zhang SJ, Bading H, Klugmann M. Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice. Bmc Neuroscience. 8: 105. PMID 18053176 DOI: 10.1186/1471-2202-8-105  0.304
2007 Vengeliene V, Heidbreder CA, Spanagel R. The effects of lamotrigine on alcohol seeking and relapse. Neuropharmacology. 53: 951-7. PMID 17976664 DOI: 10.1016/J.Neuropharm.2007.09.006  0.345
2007 Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R. Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neuroscience Letters. 416: 275-8. PMID 17350761 DOI: 10.1016/J.Neulet.2007.02.024  0.324
2006 Vengeliene V, Leonardi-Essmann F, Perreau-Lenz S, Gebicke-Haerter P, Drescher K, Gross G, Spanagel R. The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2223-33. PMID 17077299 DOI: 10.1096/Fj.06-6110Com  0.363
2006 Treutlein J, Kissling C, Frank J, Wiemann S, Dong L, Depner M, Saam C, Lascorz J, Soyka M, Preuss UW, Rujescu D, Skowronek MH, Rietschel M, Spanagel R, Heinz A, et al. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Molecular Psychiatry. 11: 594-602. PMID 16550213 DOI: 10.1038/Sj.Mp.4001813  0.324
2006 Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R. Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1231-8. PMID 16436610 DOI: 10.1523/Jneurosci.4237-05.2006  0.376
2005 Spanagel R, Heilig M. Addiction and its brain science. Addiction (Abingdon, England). 100: 1813-22. PMID 16367982 DOI: 10.1111/J.1360-0443.2005.01260.X  0.339
2005 Spanagel R, Rosenwasser AM, Schumann G, Sarkar DK. Alcohol consumption and the body's biological clock. Alcoholism, Clinical and Experimental Research. 29: 1550-7. PMID 16156052 DOI: 10.1097/01.Alc.0000175074.70807.Fd  0.346
2005 Siegmund S, Vengeliene V, Singer MV, Spanagel R. Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcoholism, Clinical and Experimental Research. 29: 1139-45. PMID 16046868 DOI: 10.1097/01.Alc.0000171928.40418.46  0.325
2005 Vengeliene V, Vollmayr B, Henn FA, Spanagel R. Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior. Psychopharmacology. 178: 125-32. PMID 15719228 DOI: 10.1007/S00213-004-2013-5  0.322
2005 Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R. The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1104-10. PMID 15668725 DOI: 10.1038/Sj.Npp.1300657  0.34
2004 Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters JT, Spanagel R, Hofmann F. Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. The European Journal of Neuroscience. 20: 3498-506. PMID 15610182 DOI: 10.1111/J.1460-9568.2004.03793.X  0.342
2004 Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R. Reduced sensitivity to reward in CB1 knockout mice. Psychopharmacology. 176: 223-32. PMID 15083252 DOI: 10.1007/S00213-004-1877-8  0.321
2004 Bachteler D, Economidou D, Ciccocioppo R, Spanagel R. ACAMPROSATE, BUT NOT NERAMEXANE, REDUCES CUE-INDUCED REINSTATEMENT OF ETHANOL-SEEKING BEHAVIOR. Alcoholism: Clinical & Experimental Research. 28: 15A. DOI: 10.1097/00000374-200408002-00052  0.304
2004 Sanchis-Segura C, Zghoul T, Sprengel R, Spanagel R. GLUR-C KNOCKOUT MICE DO NOT EXHIBIT AN ALCOHOL DEPRIVATION EFFECT AND SHOW LESS ALCOHOL SEEKING BEHAVIOUR. Alcoholism: Clinical & Experimental Research. 28: 15A. DOI: 10.1097/00000374-200408002-00050  0.333
2003 Schumann G, Rujescu D, Kissling C, Soyka M, Dahmen N, Preuss UW, Wieman S, Depner M, Wellek S, Lascorz J, Bondy B, Giegling I, Anghelescu I, Cowen MS, Poustka A, ... Spanagel R, et al. Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biological Psychiatry. 54: 1422-6. PMID 14675807 DOI: 10.1016/S0006-3223(03)00635-8  0.315
2003 Vengeliene V, Siegmund S, Singer MV, Sinclair JD, Li TK, Spanagel R. A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcoholism, Clinical and Experimental Research. 27: 1048-54. PMID 12878910 DOI: 10.1097/01.Alc.0000075829.81211.0C  0.323
2003 Cowen MS, Schroff KC, Gass P, Sprengel R, Spanagel R. Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice. Neuropharmacology. 45: 325-33. PMID 12871650 DOI: 10.1016/S0028-3908(03)00174-6  0.34
2003 Deroche-Gamonet V, Sillaber I, Aouizerate B, Izawa R, Jaber M, Ghozland S, Kellendonk C, Le Moal M, Spanagel R, Schütz G, Tronche F, Piazza PV. The glucocorticoid receptor as a potential target to reduce cocaine abuse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4785-90. PMID 12805318 DOI: 10.1523/Jneurosci.23-11-04785.2003  0.403
2003 Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Wellek S, Giegling I, Klawe C, Anghelescu I, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N. No association of alcohol dependence with a NMDA-receptor 2B gene variant. Molecular Psychiatry. 8: 11-2. PMID 12556902 DOI: 10.1038/Sj.Mp.4001245  0.32
2002 Spanagel R, Siegmund S, Cowen M, Schroff KC, Schumann G, Fiserova M, Sillaber I, Wellek S, Singer M, Putzke J. The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8676-83. PMID 12351742 DOI: 10.1523/Jneurosci.22-19-08676.2002  0.34
2002 Abarca C, Albrecht U, Spanagel R. Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proceedings of the National Academy of Sciences of the United States of America. 99: 9026-30. PMID 12084940 DOI: 10.1073/Pnas.142039099  0.392
2002 Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, Holsboer F, Spanagel R. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science (New York, N.Y.). 296: 931-3. PMID 11988580 DOI: 10.1126/Science.1069836  0.339
2001 Boening JA, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, Mason BJ, Wiesbeck GA. Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcoholism, Clinical and Experimental Research. 25: 127S-131S. PMID 11391061 DOI: 10.1111/J.1530-0277.2001.Tb02386.X  0.355
2001 Li TK, Spanagel R, Colombo G, McBride WJ, Porrino LJ, Suzuki T, Rodd-Henricks ZA. Alcohol reinforcement and voluntary ethanol consumption. Alcoholism, Clinical and Experimental Research. 25: 117S-126S. PMID 11391060 DOI: 10.1111/J.1530-0277.2001.Tb02385.X  0.342
2001 Matsumoto I, Wilce PA, Buckley T, Dodd P, Puzke J, Spanagel R, Zieglgansberger W, Wolf G, Leng S, Rommelspacher H, Finckh U, Schmidt LG. Ethanol and gene expression in brain. Alcoholism, Clinical and Experimental Research. 25: 82S-86S. PMID 11391055 DOI: 10.1111/J.1530-0277.2001.Tb02379.X  0.336
2001 Azad SC, Marsicano G, Eberlein I, Putzke J, Zieglgänsberger W, Spanagel R, Lutz B. Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse. The European Journal of Neuroscience. 13: 561-8. PMID 11168564 DOI: 10.1046/J.1460-9568.2001.01431.X  0.307
2001 Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Klawe C, Anghelescu I, Giegling I, Wellek S, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N. Alcohol dependence is associated with a NMDA-receptor 2B gene variant American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 631. DOI: 10.1016/S0924-9338(02)80905-1  0.32
2000 Spanagel R, Hölter SM. Pharmacological validation of a new animal model of alcoholism. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 669-80. PMID 10943907 DOI: 10.1007/S007020070068  0.345
2000 Hölter SM, Linthorst AC, Reul JM, Spanagel R. Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats. Pharmacology, Biochemistry, and Behavior. 66: 143-51. PMID 10837854 DOI: 10.1016/S0091-3057(00)00196-9  0.321
1999 Spanagel R, Weiss F. The dopamine hypothesis of reward: past and current status. Trends in Neurosciences. 22: 521-7. PMID 10529820 DOI: 10.1016/S0166-2236(99)01447-2  0.341
1998 Spanagel R, Sillaber I, Zieglgänsberger W, Corrigall WA, Stewart J, Shaham Y. Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology. 139: 391-401. PMID 9809860 DOI: 10.1007/S002130050730  0.35
1998 Azzi M, Betancur C, Sillaber I, Spanagel R, Rostène W, Bérod A. Repeated administration of the neurotensin receptor antagonist SR 48692 differentially regulates mesocortical and mesolimbic dopaminergic systems. Journal of Neurochemistry. 71: 1158-67. PMID 9721741 DOI: 10.1046/J.1471-4159.1998.71031158.X  0.321
1998 Sillaber I, Montkowski A, Landgraf R, Barden N, Holsboer F, Spanagel R. Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide. Neuroscience. 85: 415-25. PMID 9622241 DOI: 10.1016/S0306-4522(97)00607-6  0.336
1998 Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520  0.325
1998 Sillaber I, Timpl P, Wurst W, Holsboer F, Spanagel R. ALCOHOL DRINKING AND WITHDRAWAL IN MICE LACKING A FUNCTIONAL CRH RECEPTOR 1 Behavioural Pharmacology. 9: S82. DOI: 10.1097/00008877-199808000-00191  0.343
1997 Skutella T, Schwarting RK, Huston JP, Sillaber I, Probst JC, Holsboer F, Spanagel R. Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour. The European Journal of Neuroscience. 9: 210-20. PMID 9058042 DOI: 10.1111/J.1460-9568.1997.Tb01392.X  0.312
1995 Spanagel R, Montkowski A, Allingham K, Stöhr T, Shoaib M, Holsboer F, Landgraf R. Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. Psychopharmacology. 122: 369-73. PMID 8657835 DOI: 10.1007/Bf02246268  0.3
1995 Shoaib M, Spanagel R, Stohr T, Shippenberg TS. Strain differences in the rewarding and dopamine-releasing effects of morphine in rats. Psychopharmacology. 117: 240-7. PMID 7753973 DOI: 10.1007/Bf02245193  0.312
1994 Shoaib M, Spanagel R. Mesolimbic sites mediate the discriminative stimulus effects of morphine. European Journal of Pharmacology. 252: 69-75. PMID 8149996 DOI: 10.1016/0014-2999(94)90576-2  0.311
1994 Spanagel R, Shoaib M. Involvement of mesolimbic kappa-opioid systems in the discriminative stimulus effects of morphine. Neuroscience. 63: 797-804. PMID 7898679 DOI: 10.1016/0306-4522(94)90524-X  0.301
1994 Spanagel R, Almeida OF, Bartl C, Shippenberg TS. Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release. Psychopharmacology. 115: 121-7. PMID 7862883 DOI: 10.1007/Bf02244761  0.313
1992 Spanagel R, Herz A, Shippenberg TS. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. 89: 2046-50. PMID 1347943 DOI: 10.1073/Pnas.89.6.2046  0.321
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