Edwin R. Chapman, Ph.D. - Publications

Affiliations: 
Neuroscience University of Wisconsin, Madison, Madison, WI 
Area:
Membrane fusion, exocytosis, clostridial neurotoxins

158 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bradberry MM, Bao H, Lou X, Chapman ER. PIP drives Ca-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β. The Journal of Biological Chemistry. PMID 31147445 DOI: 10.1074/jbc.RA119.007929  0.52
2019 Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proceedings of the National Academy of Sciences of the United States of America. PMID 31110017 DOI: 10.1073/pnas.1903049116  0.52
2019 Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB. Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin. Journal of Molecular Biology. PMID 31004665 DOI: 10.1016/j.jmb.2019.04.006  0.88
2019 Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, ... ... Chapman ER, et al. Author Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nature Methods. PMID 30820033 DOI: 10.1038/s41592-019-0363-5  0.52
2019 Shen M, Wang F, Li M, Sah N, Stockton ME, Tidei JJ, Gao Y, Korabelnikov T, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, van Praag H, Zhao X. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Nature Neuroscience. PMID 30742117 DOI: 10.1038/s41593-019-0338-y  0.64
2019 Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin J, et al. Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. The Journal of General Physiology. PMID 30718376 DOI: 10.1085/jgp.201812201  0.52
2019 Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Urra Quiroz FJ, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, ... ... Chapman ER, et al. Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nature Methods. PMID 30602783 DOI: 10.1038/s41592-018-0300-z  0.52
2018 Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, ... ... Chapman ER, et al. Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nature Methods. PMID 30377363 DOI: 10.1038/s41592-018-0171-3  0.52
2018 Slosarek EL, Schuh AL, Pustova I, Johnson A, Bird J, Johnson M, Frankel EB, Bhattacharya N, Hanna MG, Burke JE, Ruhl DA, Quinney K, Block S, Peotter JL, Chapman ER, et al. Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation. Cell Reports. 24: 2248-2260. PMID 30157421 DOI: 10.1016/j.celrep.2018.07.081  0.64
2018 Xue R, Ruhl DA, Briguglio JS, Figueroa AG, Pearce RA, Chapman ER. Doc2-mediated superpriming supports synaptic augmentation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844163 DOI: 10.1073/pnas.1802104115  0.84
2018 Courtney NA, Briguglio JS, Bradberry MM, Greer C, Chapman ER. Excitatory and Inhibitory Neurons Utilize Different Ca Sensors and Sources to Regulate Spontaneous Release. Neuron. PMID 29754754 DOI: 10.1016/j.neuron.2018.04.022  0.68
2018 Bendahmane M, Bohannon KP, Bradberry MM, Rao TC, Schmidtke MW, Abbineni PS, Chon NL, Tran S, Lin H, Chapman ER, Knight JD, Anantharam A. The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion. Molecular Biology of the Cell. PMID 29444959 DOI: 10.1091/mbc.E17-11-0623  0.52
2018 Bao H, Das D, Courtney NA, Jiang Y, Briguglio JS, Lou X, Roston D, Cui Q, Chanda B, Chapman ER. Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties. Nature. 554: 260-263. PMID 29420480 DOI: 10.1038/nature25481  0.68
2017 Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Reports. 21: 3794-3806. PMID 29281828 DOI: 10.1016/j.celrep.2017.12.005  0.52
2017 Rao TC, Santana Rodriguez Z, Bradberry MM, Ranski AH, Dahl PJ, Schmidtke MW, Jenkins PM, Axelrod D, Chapman ER, Giovannucci DR, Anantharam A. Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules. The Journal of General Physiology. PMID 28687607 DOI: 10.1085/jgp.201711757  0.52
2017 Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE. Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes. The Journal of Biological Chemistry. PMID 28515322 DOI: 10.1074/jbc.M116.773523  0.96
2016 McVicker DP, Awe AM, Richters KE, Wilson RL, Cowdrey DA, Hu X, Chapman ER, Dent EW. Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity. Nature Communications. 7: 12741. PMID 27658622 DOI: 10.1038/ncomms12741  1
2016 Bomba-Warczak E, Vevea JD, Brittain JM, Figueroa-Bernier A, Tepp WH, Johnson EA, Yeh FL, Chapman ER. Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons. Cell Reports. PMID 27498860 DOI: 10.1016/j.celrep.2016.06.104  1
2016 Hullinger R, Li M, Wang J, Peng Y, Dowell JA, Bomba-Warczak E, Mitchell HA, Burger C, Chapman ER, Denu JM, Li L, Puglielli L. Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation. The Journal of Experimental Medicine. PMID 27242167 DOI: 10.1084/jem.20151776  0.68
2016 Dolai S, Xie L, Zhu D, Liang T, Qin T, Xie H, Kang Y, Chapman ER, Gaisano HY. Synaptotagmin-7 functions to replenish insulin granules for exocytosis in human islet β-cell. Diabetes. PMID 27207520 DOI: 10.2337/db15-1436  1
2016 Bai H, Xue R, Bao H, Zhang L, Yethiraj A, Cui Q, Chapman ER. Different states of synaptotagmin regulate evoked versus spontaneous release. Nature Communications. 7: 10971. PMID 27001899 DOI: 10.1038/ncomms10971  1
2016 Evans CS, He Z, Bai H, Lou X, Jeggle P, Sutton RB, Edwardson JM, Chapman ER. Functional analysis of the interface between the tandem C2-domains of synaptotagmin-1. Molecular Biology of the Cell. PMID 26792839 DOI: 10.1091/mbc.E15-07-0503  1
2015 Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB. Lipid-anchored synaptobrevin provides little or no support for exocytosis or liposome fusion. The Journal of Biological Chemistry. PMID 26663078 DOI: 10.1074/jbc.M115.701169  0.88
2015 Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM, Chapman ER. Exocytotic fusion pores are composed of both lipids and proteins. Nature Structural & Molecular Biology. PMID 26656855 DOI: 10.1038/nsmb.3141  0.36
2015 Hanna MG, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. Sar1 GTPase activity is regulated by membrane curvature. The Journal of Biological Chemistry. PMID 26546679 DOI: 10.1074/jbc.M115.672287  0.36
2015 Roper LK, Briguglio JS, Evans CS, Jackson MB, Chapman ER. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9. Nature Communications. 6: 8645. PMID 26482442 DOI: 10.1038/ncomms9645  1
2015 Evans CS, Ruhl DA, Chapman ER. An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11769-79. PMID 26311762 DOI: 10.1523/JNEUROSCI.1694-15.2015  1
2015 Xue R, Gaffaney JD, Chapman ER. Structural elements that underlie Doc2β function during asynchronous synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 112: E4316-25. PMID 26195798 DOI: 10.1073/pnas.1502288112  1
2015 Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5772-80. PMID 25855187 DOI: 10.1523/JNEUROSCI.3983-14.2015  0.88
2015 Lippmann ES, Williams CE, Ruhl DA, Estevez-Silva MC, Chapman ER, Coon JJ, Ashton RS. Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm. Stem Cell Reports. 4: 632-44. PMID 25843047 DOI: 10.1016/j.stemcr.2015.02.018  0.88
2014 Rao TC, Passmore DR, Peleman AR, Das M, Chapman ER, Anantharam A. Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules. Molecular Biology of the Cell. 25: 2416-27. PMID 24943843 DOI: 10.1091/mbc.E14-02-0702  1
2014 Liu H, Bai H, Xue R, Takahashi H, Edwardson JM, Chapman ER. Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission. Nature Neuroscience. 17: 670-7. PMID 24657966 DOI: 10.1038/nn.3681  1
2014 Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 3: e01524. PMID 24569478 DOI: 10.7554/eLife.01524  1
2014 Gaffaney JD, Xue R, Chapman ER. Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission. Molecular Biology of the Cell. 25: 481-94. PMID 24356452 DOI: 10.1091/mbc.E13-10-0571  1
2014 Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment Elife. 2014. DOI: 10.7554/eLife.01524.001  1
2013 Saludes JP, Morton LA, Coulup SK, Fiorini Z, Cook BM, Beninson L, Chapman ER, Fleshner M, Yin H. Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles. Molecular Biosystems. 9: 2005-9. PMID 23715428 DOI: 10.1039/c3mb70109c  1
2013 Liu H, Chapman ER, Dean C. "Self" versus "non-self" connectivity dictates properties of synaptic transmission and plasticity. Plos One. 8: e62414. PMID 23658626 DOI: 10.1371/journal.pone.0062414  1
2013 Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nürnberg G, Altmüller J, Saxena R, Chapman ER, Dent EW, Nürnberg P, et al. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. Proceedings of the National Academy of Sciences of the United States of America. 110: 5091-6. PMID 23479643 DOI: 10.1073/pnas.1217197110  1
2013 Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. Acs Chemical Biology. 8: 218-25. PMID 23075500 DOI: 10.1021/cb300429e  1
2012 Kwon SE, Chapman ER. Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles. The Journal of Biological Chemistry. 287: 35658-68. PMID 22908222 DOI: 10.1074/jbc.M112.398883  1
2012 Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER. All three components of the neuronal SNARE complex contribute to secretory vesicle docking. The Journal of Cell Biology. 198: 323-30. PMID 22869597 DOI: 10.1083/jcb.201106158  1
2012 Saludes JP, Morton LA, Ghosh N, Beninson LA, Chapman ER, Fleshner M, Yin H. Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I. Acs Chemical Biology. 7: 1629-35. PMID 22769435 DOI: 10.1021/cb3002705  1
2012 Sun S, Tepp WH, Johnson EA, Chapman ER. Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH. Biochemistry. 51: 5655-62. PMID 22720883 DOI: 10.1021/bi3004928  1
2012 Dean C, Liu H, Staudt T, Stahlberg MA, Vingill S, Bückers J, Kamin D, Engelhardt J, Jackson MB, Hell SW, Chapman ER. Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5398-413. PMID 22514304 DOI: 10.1523/JNEUROSCI.4515-11.2012  1
2012 Dean C, Dunning FM, Liu H, Bomba-Warczak E, Martens H, Bharat V, Ahmed S, Chapman ER. Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen. Molecular Biology of the Cell. 23: 1715-27. PMID 22398727 DOI: 10.1091/mbc.E11-08-0707  1
2012 Striegel AR, Biela LM, Evans CS, Wang Z, Delehoy JB, Sutton RB, Chapman ER, Reist NE. Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1253-60. PMID 22279210 DOI: 10.1523/JNEUROSCI.4652-11.2012  1
2012 Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER. Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nature Neuroscience. 15: 243-9. PMID 22197832 DOI: 10.1038/nn.3013  1
2011 Wang Z, Liu H, Gu Y, Chapman ER. Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion. The Journal of Cell Biology. 195: 1159-70. PMID 22184197 DOI: 10.1083/jcb.201104079  1
2011 Yeh FL, Zhu Y, Tepp WH, Johnson EA, Bertics PJ, Chapman ER. Retargeted clostridial neurotoxins as novel agents for treating chronic diseases. Biochemistry. 50: 10419-21. PMID 22047069 DOI: 10.1021/bi201490t  1
2011 Yao J, Gaffaney JD, Kwon SE, Chapman ER. Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell. 147: 666-77. PMID 22036572 DOI: 10.1016/j.cell.2011.09.046  1
2011 Sun S, Suresh S, Liu H, Tepp WH, Johnson EA, Edwardson JM, Chapman ER. Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly. Cell Host & Microbe. 10: 237-47. PMID 21925111 DOI: 10.1016/j.chom.2011.06.012  1
2011 Wu Y, Ma L, Cheley S, Bayley H, Cui Q, Chapman ER. Permeation of styryl dyes through nanometer-scale pores in membranes. Biochemistry. 50: 7493-502. PMID 21815625 DOI: 10.1021/bi2006288  1
2011 Kwon SE, Chapman ER. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron. 70: 847-54. PMID 21658579 DOI: 10.1016/j.neuron.2011.04.001  1
2011 Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. Mechanism and function of synaptotagmin-mediated membrane apposition. Nature Structural & Molecular Biology. 18: 813-21. PMID 21642967 DOI: 10.1038/nsmb.2075  1
2011 Zhang Z, Wu Y, Wang Z, Dunning FM, Rehfuss J, Ramanan D, Chapman ER, Jackson MB. Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Molecular Biology of the Cell. 22: 2324-36. PMID 21551071 DOI: 10.1091/mbc.E11-02-0159  1
2011 Wang D, Zhang Z, Dong M, Sun S, Chapman ER, Jackson MB. Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin. Biochemistry. 50: 2711-3. PMID 21401123 DOI: 10.1021/bi200290p  1
2011 Paddock BE, Wang Z, Biela LM, Chen K, Getzy MD, Striegel A, Richmond JE, Chapman ER, Featherstone DE, Reist NE. Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2248-57. PMID 21307261 DOI: 10.1523/JNEUROSCI.3153-09.2011  1
2011 Mayers JR, Fyfe I, Schuh AL, Chapman ER, Edwardson JM, Audhya A. ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously. The Journal of Biological Chemistry. 286: 9636-45. PMID 21193406 DOI: 10.1074/jbc.M110.185363  1
2010 Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER. SV2 mediates entry of tetanus neurotoxin into central neurons. Plos Pathogens. 6: e1001207. PMID 21124874 DOI: 10.1371/journal.ppat.1001207  1
2010 Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D. Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13281-90. PMID 20926654 DOI: 10.1523/JNEUROSCI.2528-10.2010  1
2010 Johnson CP, Chapman ER. Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion. The Journal of Cell Biology. 191: 187-97. PMID 20921140 DOI: 10.1083/jcb.201002089  1
2010 Wang Z, Chapman ER. Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. The Journal of Biological Chemistry. 285: 30759-66. PMID 20688915 DOI: 10.1074/jbc.M110.137745  1
2010 Zhang Z, Hui E, Chapman ER, Jackson MB. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Molecular Biology of the Cell. 21: 2821-31. PMID 20573977 DOI: 10.1091/mbc.E10-04-0285  1
2010 Stenmark P, Dong M, Dupuy J, Chapman ER, Stevens RC. Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding. Journal of Molecular Biology. 397: 1287-97. PMID 20219474 DOI: 10.1016/j.jmb.2010.02.041  1
2010 Arthur CP, Dean C, Pagratis M, Chapman ER, Stowell MH. Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons. Neuroscience. 167: 135-42. PMID 20138128 DOI: 10.1016/j.neuroscience.2010.01.056  1
2009 Abdulreda MH, Bhalla A, Rico F, Berggren PO, Chapman ER, Moy VT. Pulling force generated by interacting SNAREs facilitates membrane hemifusion. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 301-10. PMID 20023730 DOI: 10.1039/b900685k  1
2009 Zhang Z, Hui E, Chapman ER, Jackson MB. Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Molecular Biology of the Cell. 20: 5086-95. PMID 19828732 DOI: 10.1091/mbc.E09-08-0691  1
2009 Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 138: 709-21. PMID 19703397 DOI: 10.1016/j.cell.2009.05.049  1
2009 Wittenmayer N, Körber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T. Postsynaptic Neuroligin1 regulates presynaptic maturation. Proceedings of the National Academy of Sciences of the United States of America. 106: 13564-9. PMID 19628693 DOI: 10.1073/pnas.0905819106  1
2009 Wu Y, Yeh FL, Mao F, Chapman ER. Biophysical characterization of styryl dye-membrane interactions. Biophysical Journal. 97: 101-9. PMID 19580748 DOI: 10.1016/j.bpj.2009.04.028  1
2009 Liu H, Dean C, Arthur CP, Dong M, Chapman ER. Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7395-403. PMID 19515907 DOI: 10.1523/JNEUROSCI.1341-09.2009  1
2009 Wang T, Smith EA, Chapman ER, Weisshaar JC. Lipid mixing and content release in single-vesicle, SNARE-driven fusion assay with 1-5 ms resolution. Biophysical Journal. 96: 4122-31. PMID 19450483 DOI: 10.1016/j.bpj.2009.02.050  1
2009 Dean C, Liu H, Dunning FM, Chang PY, Jackson MB, Chapman ER. Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nature Neuroscience. 12: 767-76. PMID 19448629 DOI: 10.1038/nn.2315  1
2009 Zhang Z, Bhalla A, Dean C, Chapman ER, Jackson MB. Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals. Nature Neuroscience. 12: 163-71. PMID 19136969 DOI: 10.1038/nn.2252  1
2009 Chicka MC, Chapman ER. Concurrent binding of complexin and synaptotagmin to liposome-embedded SNARE complexes. Biochemistry. 48: 657-9. PMID 19128031 DOI: 10.1021/bi801962d  1
2008 Dong M, Liu H, Tepp WH, Johnson EA, Janz R, Chapman ER. Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. Molecular Biology of the Cell. 19: 5226-37. PMID 18815274 DOI: 10.1091/mbc.E08-07-0765  1
2008 Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. The Journal of Biological Chemistry. 283: 31763-75. PMID 18784080 DOI: 10.1074/jbc.M803355200  1
2008 Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7458-66. PMID 18650324 DOI: 10.1523/JNEUROSCI.0197-08.2008  1
2008 Chicka MC, Hui E, Liu H, Chapman ER. Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nature Structural & Molecular Biology. 15: 827-35. PMID 18622390 DOI: 10.1038/nsmb.1463  1
2008 Jackson MB, Chapman ER. The fusion pores of Ca2+ -triggered exocytosis. Nature Structural & Molecular Biology. 15: 684-9. PMID 18596819 DOI: 10.1038/nsmb.1449  1
2008 Bhalla A, Chicka MC, Chapman ER. Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. The Journal of Biological Chemistry. 283: 21799-807. PMID 18508778 DOI: 10.1074/jbc.M709628200  1
2008 Chapman ER. How does synaptotagmin trigger neurotransmitter release? Annual Review of Biochemistry. 77: 615-41. PMID 18275379 DOI: 10.1146/annurev.biochem.77.062005.101135  1
2008 Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 47: 2143-52. PMID 18205405 DOI: 10.1021/bi701879g  1
2008 Liu T, Wang T, Chapman ER, Weisshaar JC. Productive hemifusion intermediates in fast vesicle fusion driven by neuronal SNAREs. Biophysical Journal. 94: 1303-14. PMID 17951297 DOI: 10.1529/biophysj.107.107896  1
2008 Abdulreda MH, Bhalla A, Chapman ER, Moy VT. Atomic force microscope spectroscopy reveals a hemifusion intermediate during soluble N-ethylmaleimide-sensitive factor-attachment protein receptors-mediated membrane fusion. Biophysical Journal. 94: 648-55. PMID 17872963 DOI: 10.1529/biophysj.107.114298  1
2007 Dong M, Tepp WH, Liu H, Johnson EA, Chapman ER. Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons. The Journal of Cell Biology. 179: 1511-22. PMID 18158333 DOI: 10.1083/jcb.200707184  1
2006 Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC. Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature. 444: 1096-100. PMID 17167418 DOI: 10.1038/nature05411  1
2006 Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W, Andrews NW. Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. The Journal of Cell Biology. 174: 997-1007. PMID 16982801 DOI: 10.1083/jcb.200605004  1
2006 Hui E, Bai J, Chapman ER. Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophysical Journal. 91: 1767-77. PMID 16782782 DOI: 10.1529/biophysj.105.080325  1
2006 Jackson MB, Chapman ER. Fusion pores and fusion machines in Ca2+-triggered exocytosis. Annual Review of Biophysics and Biomolecular Structure. 35: 135-60. PMID 16689631 DOI: 10.1146/annurev.biophys.35.040405.101958  1
2006 Liu W, Montana V, Bai J, Chapman ER, Mohideen U, Parpura V. Single molecule mechanical probing of the SNARE protein interactions. Biophysical Journal. 91: 744-58. PMID 16648158 DOI: 10.1529/biophysj.105.073312  1
2006 Bhalla A, Chicka MC, Tucker WC, Chapman ER. Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion. Nature Structural & Molecular Biology. 13: 323-30. PMID 16565726 DOI: 10.1038/nsmb1076  1
2006 Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER. SV2 is the protein receptor for botulinum neurotoxin A. Science (New York, N.Y.). 312: 592-6. PMID 16543415 DOI: 10.1126/science.1123654  1
2006 Wang CT, Bai J, Chang PY, Chapman ER, Jackson MB. Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation. The Journal of Physiology. 570: 295-307. PMID 16293646 DOI: 10.1113/jphysiol.2005.097378  1
2005 Wang P, Chicka MC, Bhalla A, Richards DA, Chapman ER. Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor. Molecular and Cellular Biology. 25: 8693-702. PMID 16166648 DOI: 10.1128/MCB.25.19.8693-8702.2005  1
2005 Parpura V, Chapman ER. Detection of botulinum toxins: micromechanical and fluorescence-based sensors. Croatian Medical Journal. 46: 491-7. PMID 16100750  1
2005 Bhalla A, Tucker WC, Chapman ER. Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion. Molecular Biology of the Cell. 16: 4755-64. PMID 16093350 DOI: 10.1091/mbc.E05-04-0277  1
2005 Liu T, Tucker WC, Bhalla A, Chapman ER, Weisshaar JC. SNARE-driven, 25-millisecond vesicle fusion in vitro. Biophysical Journal. 89: 2458-72. PMID 16055544 DOI: 10.1529/biophysj.105.062539  1
2005 Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 5210-4. PMID 15793006 DOI: 10.1073/pnas.0500941102  1
2005 Madziva MT, Bai J, Bhalla A, Chapman ER, Edwardson JM. Effects of synaptotagmin reveal two distinct mechanisms of agonist-stimulated internalization of the M4 muscarinic acetylcholine receptor. British Journal of Pharmacology. 144: 761-71. PMID 15778699 DOI: 10.1038/sj.bjp.0706035  1
2005 Richards DA, Bai J, Chapman ER. Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles. The Journal of Cell Biology. 168: 929-39. PMID 15767463 DOI: 10.1083/jcb.200407148  1
2005 Maher BJ, Mackinnon RL, Bai J, Chapman ER, Kelly PT. Activation of postsynaptic Ca(2+) stores modulates glutamate receptor cycling in hippocampal neurons. Journal of Neurophysiology. 93: 178-88. PMID 15604462 DOI: 10.1152/jn.00651.2004  1
2005 Shen SS, Tucker WC, Chapman ER, Steinhardt RA. Molecular regulation of membrane resealing in 3T3 fibroblasts. The Journal of Biological Chemistry. 280: 1652-60. PMID 15536080 DOI: 10.1074/jbc.M410136200  1
2004 Dong M, Tepp WH, Johnson EA, Chapman ER. Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 14701-6. PMID 15465919 DOI: 10.1073/pnas.0404107101  1
2004 Grishanin RN, Kowalchyk JA, Klenchin VA, Ann K, Earles CA, Chapman ER, Gerona RR, Martin TF. CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein. Neuron. 43: 551-62. PMID 15312653 DOI: 10.1016/j.neuron.2004.07.028  1
2004 Bai J, Wang CT, Richards DA, Jackson MB, Chapman ER. Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions. Neuron. 41: 929-42. PMID 15046725 DOI: 10.1016/S0896-6273(04)00117-5  1
2004 Tucker WC, Weber T, Chapman ER. Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs. Science (New York, N.Y.). 304: 435-8. PMID 15044754 DOI: 10.1126/science.1097196  1
2004 Han X, Wang CT, Bai J, Chapman ER, Jackson MB. Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis. Science (New York, N.Y.). 304: 289-92. PMID 15016962 DOI: 10.1126/science.1095801  1
2004 Bai J, Chapman ER. The C2 domains of synaptotagmin--partners in exocytosis. Trends in Biochemical Sciences. 29: 143-51. PMID 15003272 DOI: 10.1016/j.tibs.2004.01.008  1
2004 Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER, Benos DJ. ENaC subunit-subunit interactions and inhibition by syntaxin 1A. American Journal of Physiology. Renal Physiology. 286: F1100-6. PMID 14996668 DOI: 10.1152/ajprenal.00344.2003  1
2004 Chieregatti E, Chicka MC, Chapman ER, Baldini G. SNAP-23 functions in docking/fusion of granules at low Ca2+. Molecular Biology of the Cell. 15: 1918-30. PMID 14742706 DOI: 10.1091/mbc.E03-09-0684  1
2004 Bai J, Tucker WC, Chapman ER. PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nature Structural & Molecular Biology. 11: 36-44. PMID 14718921 DOI: 10.1038/nsmb709  1
2003 Liu W, Montana V, Chapman ER, Mohideen U, Parpura V. Botulinum toxin type B micromechanosensor. Proceedings of the National Academy of Sciences of the United States of America. 100: 13621-5. PMID 14573702 DOI: 10.1073/pnas.2233819100  1
2003 Dong M, Richards DA, Goodnough MC, Tepp WH, Johnson EA, Chapman ER. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. The Journal of Cell Biology. 162: 1293-303. PMID 14504267 DOI: 10.1083/jcb.200305098  1
2003 Wang P, Wang CT, Bai J, Jackson MB, Chapman ER. Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner. The Journal of Biological Chemistry. 278: 47030-7. PMID 12963743 DOI: 10.1074/jbc.M306728200  1
2003 Wang CT, Lu JC, Bai J, Chang PY, Martin TF, Chapman ER, Jackson MB. Different domains of synaptotagmin control the choice between kiss-and-run and full fusion. Nature. 424: 943-7. PMID 12931189 DOI: 10.1038/nature01857  1
2003 Tucker WC, Edwardson JM, Bai J, Kim HJ, Martin TF, Chapman ER. Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. The Journal of Cell Biology. 162: 199-209. PMID 12860971 DOI: 10.1083/jcb.200302060  1
2003 Edwardson JM, Wang CT, Gong B, Wyttenbach A, Bai J, Jackson MB, Chapman ER, Morton AJ. Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II. The Journal of Biological Chemistry. 278: 30849-53. PMID 12807877 DOI: 10.1074/jbc.M304615200  1
2003 Bai J, Chapman ER. Application of fluorescent probes to study mechanics and dynamics of Ca2+-triggered synaptotagmin C2 domain-membrane interactions. Methods in Enzymology. 360: 238-58. PMID 12622153 DOI: 10.1016/S0076-6879(03)60113-8  1
2003 Wu Y, He Y, Bai J, Ji SR, Tucker WC, Chapman ER, Sui SF. Visualization of synaptotagmin I oligomers assembled onto lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America. 100: 2082-7. PMID 12578982 DOI: 10.1073/pnas.0435872100  1
2002 Chapman ER. Synaptotagmin: a Ca(2+) sensor that triggers exocytosis? Nature Reviews. Molecular Cell Biology. 3: 498-508. PMID 12094216 DOI: 10.1038/nrm855  1
2002 Tucker WC, Chapman ER. Role of synaptotagmin in Ca2+-triggered exocytosis. The Biochemical Journal. 366: 1-13. PMID 12047220 DOI: 10.1042/BJ20020776  1
2002 Bai J, Wang P, Chapman ER. C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. Proceedings of the National Academy of Sciences of the United States of America. 99: 1665-70. PMID 11805296 DOI: 10.1073/pnas.032541099  1
2001 Wang CT, Grishanin R, Earles CA, Chang PY, Martin TF, Chapman ER, Jackson MB. Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science (New York, N.Y.). 294: 1111-5. PMID 11691996 DOI: 10.1126/science.1064002  1
2001 Littleton JT, Barnard RJ, Titus SA, Slind J, Chapman ER, Ganetzky B. SNARE-complex disassembly by NSF follows synaptic-vesicle fusion. Proceedings of the National Academy of Sciences of the United States of America. 98: 12233-8. PMID 11593041 DOI: 10.1073/pnas.221450198  1
2001 Earles CA, Bai J, Wang P, Chapman ER. The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis. The Journal of Cell Biology. 154: 1117-23. PMID 11551981 DOI: 10.1083/jcb.200105020  1
2001 Lewis JL, Dong M, Earles CA, Chapman ER. The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions. The Journal of Biological Chemistry. 276: 15458-65. PMID 11278966 DOI: 10.1074/jbc.M011687200  1
2001 Littleton JT, Bai J, Vyas B, Desai R, Baltus AE, Garment MB, Carlson SD, Ganetzky B, Chapman ER. synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1421-33. PMID 11222632  1
2000 Haucke V, Wenk MR, Chapman ER, Farsad K, De Camilli P. Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation. The Embo Journal. 19: 6011-9. PMID 11080148 DOI: 10.1093/emboj/19.22.6011  1
2000 Desai RC, Vyas B, Earles CA, Littleton JT, Kowalchyck JA, Martin TF, Chapman ER. The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis. The Journal of Cell Biology. 150: 1125-36. PMID 10974000 DOI: 10.1083/jcb.150.5.1125  1
2000 Bai J, Earles CA, Lewis JL, Chapman ER. Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism. The Journal of Biological Chemistry. 275: 25427-35. PMID 10840045 DOI: 10.1074/jbc.M906729199  1
1999 Davis AF, Bai J, Fasshauer D, Wolowick MJ, Lewis JL, Chapman ER. Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes. Neuron. 24: 363-76. PMID 10571230 DOI: 10.1016/S0896-6273(00)80850-8  1
1999 Littleton JT, Serano TL, Rubin GM, Ganetzky B, Chapman ER. Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Nature. 400: 757-60. PMID 10466723 DOI: 10.1038/23462  1
1998 Chapman ER, Desai RC, Davis AF, Tornehl CK. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. The Journal of Biological Chemistry. 273: 32966-72. PMID 9830048 DOI: 10.1074/jbc.273.49.32966  1
1998 Chae YK, Abildgaard F, Chapman ER, Markley JL. Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy. The Journal of Biological Chemistry. 273: 25659-63. PMID 9748232 DOI: 10.1074/jbc.273.40.25659  1
1998 Littleton JT, Chapman ER, Kreber R, Garment MB, Carlson SD, Ganetzky B. Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron. 21: 401-13. PMID 9728921  1
1998 Chapman ER, Davis AF. Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers. The Journal of Biological Chemistry. 273: 13995-4001. PMID 9593749 DOI: 10.1074/jbc.273.22.13995  1
1996 Ruiz-Montasell B, Aguado F, Majó G, Chapman ER, Canals JM, Marsal J, Blasi J. Differential distribution of syntaxin isoforms 1A and 1B in the rat central nervous system. The European Journal of Neuroscience. 8: 2544-52. PMID 8996803 DOI: 10.1111/j.1460-9568.1996.tb01548.x  1
1996 Chapman ER, Blasi J, An S, Brose N, Johnston PA, Südhof TC, Jahn R. Fatty acylation of synaptotagmin in PC12 cells and synaptosomes. Biochemical and Biophysical Research Communications. 225: 326-32. PMID 8769138 DOI: 10.1006/bbrc.1996.1174  1
1996 Chapman ER, An S, Edwardson JM, Jahn R. A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization. The Journal of Biological Chemistry. 271: 5844-9. PMID 8621455  1
1995 Chapman ER, Hanson PI, Jahn R. The neuronal exocytotic fusion machine: some new developments. Neuropharmacology. 34: 1343-9. PMID 8606783 DOI: 10.1016/0028-3908(95)00147-X  1
1995 Walch-Solimena C, Blasi J, Edelmann L, Chapman ER, von Mollard GF, Jahn R. The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling. The Journal of Cell Biology. 128: 637-45. PMID 7860636 DOI: 10.1083/jcb.128.4.637  1
1995 Edelmann L, Hanson PI, Chapman ER, Jahn R. Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. The Embo Journal. 14: 224-31. PMID 7835333  1
1995 Otto H, Hanson PI, Chapman ER, Blasi J, Jahn R. Poisoning by botulinum neurotoxin A does not inhibit formation or disassembly of the synaptosomal fusion complex. Biochemical and Biophysical Research Communications. 212: 945-52. PMID 7626135 DOI: 10.1006/bbrc.1995.2061  1
1995 Chapman ER, Hanson PI, An S, Jahn R. Ca2+ regulates the interaction between synaptotagmin and syntaxin 1. The Journal of Biological Chemistry. 270: 23667-71. PMID 7559535  1
1994 Chapman ER, Jahn R. Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain. The Journal of Biological Chemistry. 269: 5735-41. PMID 8119912  1
1994 Chapman ER, An S, Barton N, Jahn R. SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. The Journal of Biological Chemistry. 269: 27427-32. PMID 7961655  1
1994 Li C, Takei K, Geppert M, Daniell L, Stenius K, Chapman ER, Jahn R, De Camilli P, Südhof TC. Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C. Neuron. 13: 885-98. PMID 7946335 DOI: 10.1016/0896-6273(94)90254-2  1
1994 Link E, Blasi J, Chapman ER, Edelmann L, Baumeister A, Binz T, Yamasaki S, Niemann H, Jahn R. Tetanus and botulinal neurotoxins. Tools to understand exocytosis in neurons. Advances in Second Messenger and Phosphoprotein Research. 29: 47-58. PMID 7848727  1
1994 Chapman ER, Jahn R. On the trail of the Ca2+ receptor(s) for exocytosis Seminars in the Neurosciences. 6: 159-165. DOI: 10.1006/smns.1994.1021  1
1993 Blasi J, Chapman ER, Link E, Binz T, Yamasaki S, De Camilli P, Südhof TC, Niemann H, Jahn R. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature. 365: 160-3. PMID 8103915 DOI: 10.1038/365160a0  1
1993 Blasi J, Chapman ER, Yamasaki S, Binz T, Niemann H, Jahn R. Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. The Embo Journal. 12: 4821-8. PMID 7901002  1
1992 Chapman ER, Alexander K, Vorherr T, Carafoli E, Storm DR. Fluorescence energy transfer analysis of calmodulin-peptide complexes. Biochemistry. 31: 12819-25. PMID 1463753  1
1992 Chapman ER, Estep RP, Storm DR. Palmitylation of neuromodulin (GAP-43) is not required for phosphorylation by protein kinase C. The Journal of Biological Chemistry. 267: 25233-8. PMID 1460023  1
1991 Chapman ER, Au D, Nicolson TA, Storm DR. Mutagenesis of the calmodulin binding domain of neuromodulin. Progress in Brain Research. 89: 37-44. PMID 1839070  1
1991 Liu YC, Chapman ER, Storm DR. Targeting of neuromodulin (GAP-43) fusion proteins to growth cones in cultured rat embryonic neurons. Neuron. 6: 411-20. PMID 1825782 DOI: 10.1016/0896-6273(91)90249-Y  1
1991 Chapman ER, Au D, Alexander KA, Nicolson TA, Storm DR. Characterization of the calmodulin binding domain of neuromodulin. Functional significance of serine 41 and phenylalanine 42. The Journal of Biological Chemistry. 266: 207-13. PMID 1824693  1
1989 Au DC, Apel ED, Chapman ER, Estep RP, Nicolson TA, Storm DR. Expression of cDNAs encoding wild-type and mutant neuromodulins in Escherichia coli: comparison with the native protein from bovine brain. Biochemistry. 28: 8142-8. PMID 2532540  1
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