Roger L. Papke - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
Area:
neuronal nicotinic acetylcholine receptors

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Bagdas D, Wilkerson JL, Kulkarni A, Toma W, AlSharari S, Gul Z, Lichtman AH, Papke RL, Thakur GA, Imad Damaj M. The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain. British Journal of Pharmacology. PMID 27243753 DOI: 10.1111/bph.13528  1
2016 Horenstein NA, Papke RL, Kulkarni AR, Chaturbhuj GU, Stokes C, Manther K, Thakur GA. Critical molecular determinants of α7 nicotinic acetylcholine receptor allosteric activation: separation of direct allosteric activation and positive allosteric modulation. The Journal of Biological Chemistry. PMID 26742843 DOI: 10.1074/jbc.M115.692392  1
2015 Quadri M, Papke RL, Horenstein NA. Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists. Bioorganic & Medicinal Chemistry. PMID 26707847 DOI: 10.1016/j.bmc.2015.12.017  1
2015 Papke RL, Horenstein NA, Stokes C. Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity. Plos One. 10: e0140907. PMID 26488401 DOI: 10.1371/journal.pone.0140907  1
2015 van Maanen MA, Papke RL, Koopman FA, Koepke J, Bevaart L, Clark R, Lamppu D, Elbaum D, LaRosa GJ, Tak PP, Vervoordeldonk MJ. Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice. Plos One. 10: e0116227. PMID 25617631 DOI: 10.1371/journal.pone.0116227  1
2015 Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI. The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology. 91: 34-42. PMID 25497451 DOI: 10.1016/j.neuropharm.2014.12.002  1
2015 Bordia T, McGregor M, Papke RL, Decker MW, McIntosh JM, Quik M. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Experimental Neurology. 263: 277-84. PMID 25261754 DOI: 10.1016/j.expneurol.2014.09.015  1
2015 Stokes C, Treinin M, Papke RL. Looking below the surface of nicotinic acetylcholine receptors Trends in Pharmacological Sciences. 36: 514-523. DOI: 10.1016/j.tips.2015.05.002  1
2014 Papke RL, Chojnacka K, Horenstein NA. The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor. The Journal of Pharmacology and Experimental Therapeutics. 350: 665-80. PMID 24990939 DOI: 10.1124/jpet.114.215236  1
2014 Ponzoni L, Braida D, Pucci L, Andrea D, Fasoli F, Manfredi I, Papke RL, Stokes C, Cannazza G, Clementi F, Gotti C, Sala M. The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors. Psychopharmacology. 231: 4681-93. PMID 24862365 DOI: 10.1007/s00213-014-3619-x  1
2014 Brunzell DH, McIntosh JM, Papke RL. Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation. Annals of the New York Academy of Sciences. 1327: 27-45. PMID 24730978 DOI: 10.1111/nyas.12421  1
2014 Papke RL. Merging old and new perspectives on nicotinic acetylcholine receptors. Biochemical Pharmacology. 89: 1-11. PMID 24486571 DOI: 10.1016/j.bcp.2014.01.029  1
2014 McClure-Begley TD, Papke RL, Stone KL, Stokes C, Levy AD, Gelernter J, Xie P, Lindstrom J, Picciotto MR. Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors. The Journal of Pharmacology and Experimental Therapeutics. 348: 410-20. PMID 24385388 DOI: 10.1124/jpet.113.209767  1
2014 Papke RL, Horenstein NA, Kulkarni AR, Stokes C, Corrie LW, Maeng CY, Thakur GA. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface. The Journal of Biological Chemistry. 289: 4515-31. PMID 24362025 DOI: 10.1074/jbc.M113.524603  1
2014 Eskildsen J, Redrobe JP, Sams AG, Dekermendjian K, Laursen M, Boll JB, Papke RL, Bundgaard C, Frederiksen K, Bastlund JF. Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration. Bioorganic & Medicinal Chemistry Letters. 24: 288-93. PMID 24291041 DOI: 10.1016/j.bmcl.2013.11.022  1
2014 Igari M, Alexander JC, Ji Y, Qi X, Papke RL, Bruijnzeel AW. Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 455-65. PMID 23966067 DOI: 10.1038/npp.2013.216  1
2013 Papke RL, Stokes C, Muldoon P, Imad Damaj M. Similar activity of mecamylamine stereoisomers in vitro and in vivo. European Journal of Pharmacology. 720: 264-75. PMID 24161916 DOI: 10.1016/j.ejphar.2013.10.018  1
2013 Eibl C, Tomassoli I, Munoz L, Stokes C, Papke RL, Gündisch D. The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents. Bioorganic & Medicinal Chemistry. 21: 7283-308. PMID 24156938 DOI: 10.1016/j.bmc.2013.09.059  1
2013 Eibl C, Munoz L, Tomassoli I, Stokes C, Papke RL, Gündisch D. The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs. Bioorganic & Medicinal Chemistry. 21: 7309-29. PMID 24145137 DOI: 10.1016/j.bmc.2013.09.060  1
2013 Thakur GA, Kulkarni AR, Deschamps JR, Papke RL. Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 56: 8943-7. PMID 24090443 DOI: 10.1021/jm401267t  1
2013 Peng C, Stokes C, Mineur YS, Picciotto MR, Tian C, Eibl C, Tomassoli I, Guendisch D, Papke RL. Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule. The Journal of Pharmacology and Experimental Therapeutics. 347: 424-37. PMID 23959137 DOI: 10.1124/jpet.113.206904  1
2013 Peng C, Kimbrell MR, Tian C, Pack TF, Crooks PA, Fifer EK, Papke RL. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Molecular Pharmacology. 84: 459-75. PMID 23839567 DOI: 10.1124/mol.113.086462  1
2013 Chojnacka K, Papke RL, Horenstein NA. Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor. Bioorganic & Medicinal Chemistry Letters. 23: 4145-9. PMID 23746476 DOI: 10.1016/j.bmcl.2013.05.039  1
2013 Isaacson MD, Horenstein NA, Stokes C, Kem WR, Papke RL. Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines. Biochemical Pharmacology. 85: 817-28. PMID 23352650 DOI: 10.1016/j.bcp.2013.01.010  1
2013 Papke RL. Water, Ions, Membranes, Pumps, and Transporters Neuroscience in the 21st Century: From Basic to Clinical. 5-28. DOI: 10.1007/978-1-4614-1997-6_2  1
2012 Williams DK, Peng C, Kimbrell MR, Papke RL. Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures. Molecular Pharmacology. 82: 746-59. PMID 22828799 DOI: 10.1124/mol.112.080317  1
2012 Stokes C, Papke RL. Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties. Neuropharmacology. 63: 538-46. PMID 22580377 DOI: 10.1016/j.neuropharm.2012.04.035  1
2012 Papke RL, Ono F, Stokes C, Urban JM, Boyd RT. The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study. Biochemical Pharmacology. 84: 352-65. PMID 22580045 DOI: 10.1016/j.bcp.2012.04.022  1
2012 Wang J, Papke RL, Stokes C, Horenstein NA. Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 21957-69. PMID 22556416 DOI: 10.1074/jbc.M112.339796  1
2012 Murray TA, Bertrand D, Papke RL, George AA, Pantoja R, Srinivasan R, Liu Q, Wu J, Whiteaker P, Lester HA, Lukas RJ. α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces. Molecular Pharmacology. 81: 175-88. PMID 22039094 DOI: 10.1124/mol.111.074088  1
2011 Williams DK, Wang J, Papke RL. Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states. Molecular Pharmacology. 80: 1013-32. PMID 21885620 DOI: 10.1124/mol.111.074302  1
2011 Williams DK, Wang J, Papke RL. Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations. Biochemical Pharmacology. 82: 915-30. PMID 21575610 DOI: 10.1016/j.bcp.2011.05.001  1
2011 Williams DK, Stokes C, Horenstein NA, Papke RL. The effective opening of nicotinic acetylcholine receptors with single agonist binding sites. The Journal of General Physiology. 137: 369-84. PMID 21444659 DOI: 10.1085/jgp.201010587  1
2011 Papke RL, Trocmé-Thibierge C, Guendisch D, Al Rubaiy SA, Bloom SA. Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists. The Journal of Pharmacology and Experimental Therapeutics. 337: 367-79. PMID 21285282 DOI: 10.1124/jpet.110.177485  1
2011 Papke RL, Stokes C, Williams DK, Wang J, Horenstein NA. Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper. Neuropharmacology. 60: 159-71. PMID 20650284 DOI: 10.1016/j.neuropharm.2010.07.014  1
2010 Wang J, Horenstein NA, Stokes C, Papke RL. Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization. Molecular Pharmacology. 78: 1012-25. PMID 20823218 DOI: 10.1124/mol.110.066662  1
2010 Papke RL. alpha4beta2 Nicotinic acetylcholine receptors, willing if able. British Journal of Pharmacology. 160: 1903-5. PMID 20649588 DOI: 10.1111/j.1476-5381.2010.00868.x  1
2010 Peng Y, Zhang Q, Snyder GL, Zhu H, Yao W, Tomesch J, Papke RL, O'Callaghan JP, Welsh WJ, Wennogle LP. Discovery of novel alpha7 nicotinic receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 4825-30. PMID 20638843 DOI: 10.1016/j.bmcl.2010.06.103  1
2010 David R, Ciuraszkiewicz A, Simeone X, Orr-Urtreger A, Papke RL, McIntosh JM, Huck S, Scholze P. Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. The European Journal of Neuroscience. 31: 978-93. PMID 20377613 DOI: 10.1111/j.1460-9568.2010.07133.x  1
2010 Papke RL, Wecker L, Stitzel JA. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. The Journal of Pharmacology and Experimental Therapeutics. 333: 501-18. PMID 20100906 DOI: 10.1124/jpet.109.164566  1
2010 Papke RL, Stokes C. Working with OpusXpress: methods for high volume oocyte experiments. Methods (San Diego, Calif.). 51: 121-33. PMID 20085813 DOI: 10.1016/j.ymeth.2010.01.012  1
2010 Papke RL. Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization. Journal of Molecular Neuroscience : Mn. 40: 77-86. PMID 19672724 DOI: 10.1007/s12031-009-9261-0  1
2009 López-Hernández GY, Thinschmidt JS, Morain P, Trocme-Thibierge C, Kem WR, Soti F, Papke RL. Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. Neuropharmacology. 56: 821-30. PMID 19705574 DOI: 10.1016/j.neuropharm.2009.01.011  1
2009 López-Hernández GY, Thinschmidt JS, Zheng G, Zhang Z, Crooks PA, Dwoskin LP, Papke RL. Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists. Molecular Pharmacology. 76: 652-66. PMID 19556356 DOI: 10.1124/mol.109.056176  1
2009 Hauser TA, Kucinski A, Jordan KG, Gatto GJ, Wersinger SR, Hesse RA, Stachowiak EK, Stachowiak MK, Papke RL, Lippiello PM, Bencherif M. TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. Biochemical Pharmacology. 78: 803-12. PMID 19482012 DOI: 10.1016/j.bcp.2009.05.030  1
2009 Grinevich VP, Papke RL, Lippiello PM, Bencherif M. Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors. Neuropharmacology. 57: 183-91. PMID 19481556 DOI: 10.1016/j.neuropharm.2009.05.003  1
2009 Williams DK, Stokes C, Horenstein NA, Papke RL. Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site. The Journal of Pharmacology and Experimental Therapeutics. 330: 40-53. PMID 19339660 DOI: 10.1124/jpet.109.151225  1
2009 Papke RL, Kem WR, Soti F, López-Hernández GY, Horenstein NA. Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. The Journal of Pharmacology and Experimental Therapeutics. 329: 791-807. PMID 19223664 DOI: 10.1124/jpet.108.150151  1
2009 Mineur YS, Eibl C, Young G, Kochevar C, Papke RL, Gündisch D, Picciotto MR. Cytisine-based nicotinic partial agonists as novel antidepressant compounds. The Journal of Pharmacology and Experimental Therapeutics. 329: 377-86. PMID 19164465 DOI: 10.1124/jpet.108.149609  1
2009 Papke RL, Smith-Maxwell C. High throughput electrophysiology with Xenopus oocytes. Combinatorial Chemistry & High Throughput Screening. 12: 38-50. PMID 19149490 DOI: 10.2174/138620709787047975  1
2009 Wang J, Papke RL, Horenstein NA. Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity. Bioorganic & Medicinal Chemistry Letters. 19: 474-6. PMID 19081250 DOI: 10.1016/j.bmcl.2008.11.044  1
2008 Rahman S, López-Hernández GY, Corrigall WA, Papke RL. Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction. Cns & Neurological Disorders Drug Targets. 7: 422-41. PMID 19128201 DOI: 10.2174/187152708786927831  1
2008 Huang X, Zheng F, Stokes C, Papke RL, Zhan CG. Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding. Journal of Medicinal Chemistry. 51: 6293-302. PMID 18826295 DOI: 10.1021/jm800607u  1
2008 Horenstein NA, Leonik FM, Papke RL. Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors. Molecular Pharmacology. 74: 1496-511. PMID 18768388 DOI: 10.1124/mol.108.048892  1
2008 Papke RL, Dwoskin LP, Crooks PA, Zheng G, Zhang Z, McIntosh JM, Stokes C. Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras. Neuropharmacology. 54: 1189-200. PMID 18448138 DOI: 10.1016/j.neuropharm.2008.03.010  1
2008 Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. The Journal of Biological Chemistry. 283: 16928-39. PMID 18387948 DOI: 10.1074/jbc.M801454200  1
2008 Thinschmidt JS, López-Hernández GY, Ren K, King MA, Meyer EM, Papke RL. Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer. Brain Research. 1203: 51-60. PMID 18321476 DOI: 10.1016/j.brainres.2008.02.011  1
2008 Rahman S, Zhang Z, Papke RL, Crooks PA, Dwoskin LP, Bardo MT. Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo. British Journal of Pharmacology. 153: 792-804. PMID 18059317 DOI: 10.1038/sj.bjp.0707612  1
2007 Dwoskin LP, Joyce BM, Zheng G, Neugebauer NM, Manda VK, Lockman P, Papke RL, Bardo MT, Crooks PA. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochemical Pharmacology. 74: 1271-82. PMID 17727820 DOI: 10.1016/j.bcp.2007.07.021  1
2007 Lopez-Hernandez G, Placzek AN, Thinschmidt JS, Lestage P, Trocme-Thibierge C, Morain P, Papke RL. Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons. Neuropharmacology. 53: 134-44. PMID 17544457 DOI: 10.1016/j.neuropharm.2007.04.007  1
2007 Leonik FM, Papke RL, Horenstein NA. Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1520-2. PMID 17276680 DOI: 10.1016/j.bmcl.2007.01.003  1
2007 Papke RL, Dwoskin LP, Crooks PA. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. Journal of Neurochemistry. 101: 160-7. PMID 17241116 DOI: 10.1111/j.1471-4159.2006.04355.x  1
2007 Ren K, Thinschmidt J, Liu J, Ai L, Papke RL, King MA, Hughes JA, Meyer EM. alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience. 145: 314-22. PMID 17218065 DOI: 10.1016/j.neuroscience.2006.11.023  1
2007 Horenstein NA, McCormack TJ, Stokes C, Ren K, Papke RL. Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 282: 5899-909. PMID 17189260 DOI: 10.1074/jbc.M609202200  1
2006 Papke RL. Estimation of both the potency and efficacy of alpha7 nAChR agonists from single-concentration responses. Life Sciences. 78: 2812-9. PMID 16343553 DOI: 10.1016/j.lfs.2005.11.009  1
2005 Papke RL, McCormack TJ, Jack BA, Wang D, Bugaj-Gaweda B, Schiff HC, Buhr JD, Waber AJ, Stokes C. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 524: 11-8. PMID 16266703 DOI: 10.1016/j.ejphar.2005.08.043  1
2005 Placzek AN, Grassi F, Meyer EM, Papke RL. An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelity. Molecular Pharmacology. 68: 1863-76. PMID 16186249 DOI: 10.1124/mol.105.016402  1
2005 Damaj MI, Wiley JL, Martin BR, Papke RL. In vivo characterization of a novel inhibitor of CNS nicotinic receptors. European Journal of Pharmacology. 521: 43-8. PMID 16181622 DOI: 10.1016/j.ejphar.2005.06.056  1
2005 Thinschmidt JS, Frazier CJ, King MA, Meyer EM, Papke RL. Medial septal/diagonal band cells express multiple functional nicotinic receptor subtypes that are correlated with firing frequency. Neuroscience Letters. 389: 163-8. PMID 16112453 DOI: 10.1016/j.neulet.2005.07.038  1
2005 Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorganic & Medicinal Chemistry Letters. 15: 3874-80. PMID 16005216 DOI: 10.1016/j.bmcl.2005.05.118  1
2005 Thinschmidt JS, Frazier CJ, King MA, Meyer EM, Papke RL. Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons. Experimental Neurology. 195: 342-52. PMID 16000197 DOI: 10.1016/j.expneurol.2005.05.006  1
2005 Graham JH, Papke RL, Buccafusco JJ. Functional central nicotinic acetylcholine receptor antagonism by systemic administration of Tinuvin 770 (BTMPS). Current Alzheimer Research. 2: 141-7. PMID 15974911 DOI: 10.2174/1567205053585747  1
2005 Ren K, Puig V, Papke RL, Itoh Y, Hughes JA, Meyer EM. Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells. Journal of Neurochemistry. 94: 926-33. PMID 15969741 DOI: 10.1111/j.1471-4159.2005.03223.x  1
2005 Papke RL, Schiff HC, Jack BA, Horenstein NA. Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist. Neuroscience Letters. 378: 140-4. PMID 15781147 DOI: 10.1016/j.neulet.2004.12.025  1
2005 Papke RL, Buhr JD, Francis MM, Choi KI, Thinschmidt JS, Horenstein NA. The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Molecular Pharmacology. 67: 1977-90. PMID 15761116 DOI: 10.1124/mol.105.011676  1
2004 Placzek AN, Grassi F, Papke T, Meyer EM, Papke RL. A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors. Molecular Pharmacology. 66: 169-77. PMID 15213309 DOI: 10.1124/mol.66.1.169  1
2004 Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL. The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Molecular Pharmacology. 66: 14-24. PMID 15213292 DOI: 10.1124/mol.66.1.14  1
2004 Dominy J, Thinschmidt JS, Peris J, Dawson R, Papke RL. Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters. Journal of Neurochemistry. 89: 1195-205. PMID 15147512 DOI: 10.1111/j.1471-4159.2004.02410.x  1
2004 Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK. Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy. Neuropharmacology. 46: 1023-38. PMID 15081799 DOI: 10.1016/j.neuropharm.2004.01.005  1
2004 Papke RL, Porter Papke JK, Rose GM. Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. Bioorganic & Medicinal Chemistry Letters. 14: 1849-53. PMID 15050614 DOI: 10.1016/j.bmcl.2003.09.104  1
2004 Marrero MB, Papke RL, Bhatti BS, Shaw S, Bencherif M. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. The Journal of Pharmacology and Experimental Therapeutics. 309: 16-27. PMID 14722323 DOI: 10.1124/jpet.103.061655  1
2004 Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Molecular Pharmacology. 65: 56-67. PMID 14722237 DOI: 10.1124/mol.65.1.56  1
2003 Frazier CJ, Strowbridge BW, Papke RL. Nicotinic receptors on local circuit neurons in dentate gyrus: a potential role in regulation of granule cell excitability. Journal of Neurophysiology. 89: 3018-28. PMID 12611982 DOI: 10.1152/jn.01036.2002  1
2003 Uteshev VV, Meyer EM, Papke RL. Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors. Journal of Neurophysiology. 89: 1797-806. PMID 12611953 DOI: 10.1152/jn.00943.2002  1
2003 Takeda D, Nakatsuka T, Papke R, Gu JG. Modulation of inhibitory synaptic activity by a non-α4β2, non-α7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord Pain. 101: 13-23. PMID 12507696 DOI: 10.1016/S0304-3959(02)00074-X  1
2002 Uteshev VV, Meyer EM, Papke RL. Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors. Brain Research. 948: 33-46. PMID 12383953 DOI: 10.1016/S0006-8993(02)02946-3  1
2002 Papke RL, Porter Papke JK. Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. British Journal of Pharmacology. 137: 49-61. PMID 12183330 DOI: 10.1038/sj.bjp.0704833  1
2002 Papke RL. Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403). The Journal of Pharmacology and Experimental Therapeutics. 301: 765-73. PMID 11961083 DOI: 10.1124/jpet.301.2.765  1
2001 Efange SM, Tu Z, von Hohenberg K, Francesconi L, Howell RC, Rampersad MV, Todaro LJ, Papke RL, Kung MP. 2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization. Journal of Medicinal Chemistry. 44: 4704-15. PMID 11741488 DOI: 10.1021/jm010129z  1
2001 Papke RL, Horenstein BA, Placzek AN. Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics. Molecular Pharmacology. 60: 1365-74. PMID 11723244  1
2001 Papke RL, Sanberg PR, Shytle RD. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. The Journal of Pharmacology and Experimental Therapeutics. 297: 646-56. PMID 11303054  1
2000 Francis MM, Vazquez RW, Papke RL, Oswald RE. Subtype-selective inhibition of neuronal nicotinic acetylcholine receptors by cocaine is determined by the alpha4 and beta4 subunits. Molecular Pharmacology. 58: 109-19. PMID 10860932  1
2000 Papke RL, Webster JC, Lippiello PM, Bencherif M, Francis MM. The activation and inhibition of human nicotinic acetylcholine receptor by RJR-2403 indicate a selectivity for the alpha4beta2 receptor subtype. Journal of Neurochemistry. 75: 204-16. PMID 10854263 DOI: 10.1046/j.1471-4159.2000.0750204.x  1
2000 Papke RL, Meyer E, Nutter T, Uteshev VV. alpha7 receptor-selective agonists and modes of alpha7 receptor activation. European Journal of Pharmacology. 393: 179-95. PMID 10771012 DOI: 10.1016/S0014-2999(00)00009-1  1
1999 Karkanias NB, Papke RL. Lithium modulates desensitization of the glutamate receptor subtype gluR3 in Xenopus oocytes. Neuroscience Letters. 277: 153-6. PMID 10626836 DOI: 10.1016/S0304-3940(99)00878-2  1
1999 Webster JC, Francis MM, Porter JK, Robinson G, Stokes C, Horenstein B, Papke RL. Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain. British Journal of Pharmacology. 127: 1337-48. PMID 10455283 DOI: 10.1038/sj.bjp.0702686  1
1999 Li Y, Papke RL, He YJ, Millard WJ, Meyer EM. Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells. Brain Research. 830: 218-25. PMID 10366678 DOI: 10.1016/S0006-8993(99)01372-4  1
1999 Karkanias NB, Papke RL. Subtype-specific effects of lithium on glutamate receptor function. Journal of Neurophysiology. 81: 1506-12. PMID 10200187  1
1998 Meyer EM, Kuryatov A, Gerzanich V, Lindstrom J, Papke RL. Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 287: 918-25. PMID 9864273  1
1998 Papke RL, Thinschmidt JS. The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes. Neuroscience Letters. 256: 163-6. PMID 9855365 DOI: 10.1016/S0304-3940(98)00786-1  1
1998 Gomez JR, Karkanias NB, Lenox RH, Papke RL. Lithium homeostasis in Xenopus oocytes: implications for the study of signal transduction. Life Sciences. 63: 1715-24. PMID 9806227 DOI: 10.1016/S0024-3205(98)00443-3  1
1998 Lenox RH, McNamara RK, Papke RL, Manji HK. Neurobiology of lithium: an update. The Journal of Clinical Psychiatry. 59: 37-47. PMID 9674936  1
1998 Francis MM, Choi KI, Horenstein BA, Papke RL. Sensitivity to voltage-independent inhibition determined by pore-lining region of the acetylcholine receptor. Biophysical Journal. 74: 2306-17. PMID 9591658 DOI: 10.1016/S0006-3495(98)77940-8  1
1998 Kabakov AY, Karkanias NB, Lenox RH, Papke RL. Synapse-specific accumulation of lithium in intracellular microdomains: a model for uncoupling coincidence detection in the brain. Synapse (New York, N.Y.). 28: 271-9. PMID 9517835 DOI: 10.1002/(SICI)1098-2396(199804)28:4<271::AID-SYN2>3.0.CO;2-6  1
1998 Meyer EM, Tay ET, Zoltewicz JA, Meyers C, King MA, Papke RL, De Fiebre CM. Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties. The Journal of Pharmacology and Experimental Therapeutics. 284: 1026-32. PMID 9495863  1
1997 Kem WR, Mahnir VM, Papke RL, Lingle CJ. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 283: 979-92. PMID 9399967  1
1997 Meyer EM, Tay ET, Papke RL, Meyers C, Huang GL, de Fiebre CM. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Research. 768: 49-56. PMID 9369300 DOI: 10.1016/S0006-8993(97)00536-2  1
1997 Papke RL, Thinschmidt JS, Moulton BA, Meyer EM, Poirier A. Activation and inhibition of rat neuronal nicotinic receptors by ABT-418. British Journal of Pharmacology. 120: 429-38. PMID 9031746 DOI: 10.1038/sj.bjp.0700930  1
1996 Francis MM, Papke RL. Muscle-type nicotinic acetylcholine receptor delta subunit determines sensitivity to noncompetitive inhibitors, while gamma subunit regulates divalent permeability. Neuropharmacology. 35: 1547-56. PMID 9025102 DOI: 10.1016/S0028-3908(96)00103-7  1
1996 Papke RL, Bencherif M, Lippiello P. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. Neuroscience Letters. 213: 201-4. PMID 8873149 DOI: 10.1016/S0304-3940(96)12889-5  1
1996 Feldman DH, Thinschmidt JS, Peel AL, Papke RL, Reier PJ. Differentiation of ionic currents in CNS progenitor cells: dependence upon substrate attachment and epidermal growth factor. Experimental Neurology. 140: 206-17. PMID 8690063 DOI: 10.1006/exnr.1996.0130  1
1995 de Fiebre CM, Meyer EM, Henry JC, Muraskin SI, Kem WR, Papke RL. Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes. Molecular Pharmacology. 47: 164-71. PMID 7838125  1
1994 Papke RL, Heinemann SF. Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit. Molecular Pharmacology. 45: 142-9. PMID 8302273  1
1994 Papke RL, Craig AG, Heinemann SF. Inhibition of nicotinic acetylcholine receptors by bis (2,2,6,6-tetramethyl- 4-piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics. The Journal of Pharmacology and Experimental Therapeutics. 268: 718-26. PMID 8113983  1
1994 Hunter BE, de Fiebre CM, Papke RL, Kem WR, Meyer EM. A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus. Neuroscience Letters. 168: 130-4. PMID 8028765 DOI: 10.1016/0304-3940(94)90433-2  1
1993 Papke RL, Duvoisin RM, Heinemann SF. The amino terminal half of the nicotinic beta-subunit extracellular domain regulates the kinetics of inhibition by neuronal bungarotoxin. Proceedings. Biological Sciences / the Royal Society. 252: 141-8. PMID 8391703 DOI: 10.1098/rspb.1993.0058  1
1993 Papke RL. The kinetic properties of neuronal nicotinic receptors: genetic basis of functional diversity. Progress in Neurobiology. 41: 509-31. PMID 7692467 DOI: 10.1016/0301-0082(93)90028-Q  1
1991 Rogers SW, Gahring LC, Papke RL, Heinemann S. Identification of cultured cells expressing ligand-gated cationic channels. Protein Expression and Purification. 2: 108-16. PMID 1726559 DOI: 10.1016/1046-5928(91)90058-Q  1
1991 Papke RL, Heinemann SF. The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors. The Journal of Physiology. 440: 95-112. PMID 1725184  1
1989 Papke RL, Boulter J, Patrick J, Heinemann S. Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. Neuron. 3: 589-96. PMID 2484342 DOI: 10.1016/0896-6273(89)90269-9  1
1989 Papke RL, Oswald RE. Mechanisms of noncompetitive inhibition of acetylcholine-induced single-channel currents. The Journal of General Physiology. 93: 785-811. PMID 2472461  1
1989 Oswald RE, Papke RL, Lukas RJ. Characterization of nicotinic acetylcholine receptor channels of the TE671 human medulloblastoma clonal line. Neuroscience Letters. 96: 207-12. PMID 2467233 DOI: 10.1016/0304-3940(89)90059-1  1
1988 Papke RL, Millhauser G, Lieberman Z, Oswald RE. Relationships of agonist properties to the single channel kinetics of nicotinic acetylcholine receptors. Biophysical Journal. 53: 1-10. PMID 2449251 DOI: 10.1016/S0006-3495(88)83059-5  1
1986 Papke RL, Podleski TR, Oswald RE. Effects of pineal factors on the action potentials of sympathetic neurons. Cellular and Molecular Neurobiology. 6: 381-95. PMID 3548991 DOI: 10.1007/BF00711407  1
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