| Year |
Citation |
Score |
| 2019 |
Martinez MN, Bhoopathy S, Carlert S, Cirit M, Fahmy R, Flanagan T, Forbes B, Jamei M, Khan MA, Lukacova V, Mochel JP, Pepin X, Pade D, Reppas C, Sinko PJ, et al. Workshop Report: USP Workshop on Exploring the Science of Drug Absorption Dissolution Technologies. 26: 38-66. DOI: 10.14227/Dt260319P38 |
0.333 |
|
| 2018 |
Hens B, Sinko P, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, et al. Formulation Predictive Dissolution (fPD) Testing to Advance Oral Drug Product Development: an Introduction to the US FDA Funded '21 Century BA/BE' Project. International Journal of Pharmaceutics. PMID 29944899 DOI: 10.1016/J.Ijpharm.2018.06.050 |
0.743 |
|
| 2018 |
Heon Lee I, Palombo MS, Zhang X, Szekely Z, Sinko PJ. Design and Evaluation of a CXCR4 Targeting Peptide 4DV3 as an HIV Entry Inhibitor and a Ligand for Targeted Drug Delivery. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 29894816 DOI: 10.1016/J.Ejpb.2018.06.004 |
0.342 |
|
| 2018 |
Gu Z, Gao D, Al-Zubaydi F, Li S, Singh Y, Rivera K, Holloway J, Szekely Z, Love S, Sinko PJ. The effect of size and polymer architecture of doxorubicin-poly(ethylene) glycol conjugate nanocarriers on breast duct retention, potency and toxicity. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29698706 DOI: 10.1016/J.Ejps.2018.04.033 |
0.676 |
|
| 2017 |
Dong H, Han L, Wu Z, Zhang T, Xie J, Ma J, Wang J, Li T, Gao Y, Shao J, Sinko PJ, Jia L. Biostable Aptamer Rings Conjugated for Targeting Two Biomarkers on Circulating Tumor Cells in Vivo with Great Precision Chemistry of Materials. 29: 10312-10325. DOI: 10.1021/Acs.Chemmater.7B03044 |
0.309 |
|
| 2015 |
Samizadeh M, Zhang X, Gunaseelan S, Nelson AG, Palombo MS, Myers DR, Singh Y, Ganapathi U, Szekely Z, Sinko PJ. Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates-proof of concept for HIV mucosal pre-exposure prophylaxis. Drug Delivery and Translational Research. PMID 26712122 DOI: 10.1007/S13346-015-0269-4 |
0.692 |
|
| 2015 |
D'Addio SM, Reddy VM, Liu Y, Sinko PJ, Einck L, Prud'homme RK. Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641. Molecular Pharmaceutics. 12: 1554-63. PMID 25811733 DOI: 10.1021/Mp5008663 |
0.351 |
|
| 2014 |
Sundara Rajan S, Turovskiy Y, Singh Y, Chikindas ML, Sinko PJ. Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment. Journal of Controlled Release : Official Journal of the Controlled Release Society. 194: 301-9. PMID 25223229 DOI: 10.1016/J.Jconrel.2014.08.031 |
0.656 |
|
| 2014 |
Chen P, Zhang X, Jia L, Prud'homme RK, Szekely Z, Sinko PJ. Optimal structural design of mannosylated nanocarriers for macrophage targeting. Journal of Controlled Release : Official Journal of the Controlled Release Society. 194: 341-9. PMID 25220160 DOI: 10.1016/J.Jconrel.2014.09.006 |
0.525 |
|
| 2014 |
Sundara Rajan S, Cavera VL, Zhang X, Singh Y, Chikindas ML, Sinko PJ. Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis. Antimicrobial Agents and Chemotherapy. 58: 2747-53. PMID 24566190 DOI: 10.1128/Aac.02446-14 |
0.656 |
|
| 2014 |
Pinkerton NM, Zhang SW, Youngblood RL, Gao D, Li S, Benson BR, Anthony J, Stone HA, Sinko PJ, Prud'homme RK. Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules. 15: 252-61. PMID 24410445 DOI: 10.1021/Bm4015232 |
0.321 |
|
| 2014 |
Palombo M, Deshmukh M, Myers D, Gao J, Szekely Z, Sinko PJ. Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery. Annual Review of Pharmacology and Toxicology. 54: 581-98. PMID 24160695 DOI: 10.1146/Annurev-Pharmtox-010611-134615 |
0.338 |
|
| 2014 |
Liu D, Zhang X, Gao J, Palombo M, Gao D, Chen P, Sinko PJ. Core functional sequence of C-terminal GAG-binding domain directs cellular uptake of IGFBP-3-derived peptides. Protein and Peptide Letters. 21: 124-31. PMID 24059751 DOI: 10.2174/09298665113206660095 |
0.486 |
|
| 2013 |
Gao J, Chen P, Singh Y, Zhang X, Szekely Z, Stein S, Sinko PJ. Novel monodisperse PEGtide dendrons: design, fabrication, and evaluation of mannose receptor-mediated macrophage targeting. Bioconjugate Chemistry. 24: 1332-44. PMID 23808323 DOI: 10.1021/Bc400011V |
0.707 |
|
| 2013 |
D'Addio SM, Baldassano S, Shi L, Cheung L, Adamson DH, Bruzek M, Anthony JE, Laskin DL, Sinko PJ, Prud'homme RK. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. Journal of Controlled Release : Official Journal of the Controlled Release Society. 168: 41-9. PMID 23419950 DOI: 10.1016/J.Jconrel.2013.02.004 |
0.36 |
|
| 2013 |
Kutscher HL, Gao D, Li S, Massa CB, Cervelli J, Deshmukh M, Joseph LB, Laskin DL, Sinko PJ. Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: implications for microemboli-based drug delivery systems. Toxicology and Applied Pharmacology. 266: 214-23. PMID 23142466 DOI: 10.1016/J.Taap.2012.10.021 |
0.729 |
|
| 2012 |
Deshmukh M, Kutscher HL, Gao D, Sunil VR, Malaviya R, Vayas K, Stein S, Laskin JD, Laskin DL, Sinko PJ. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. Journal of Controlled Release : Official Journal of the Controlled Release Society. 164: 65-73. PMID 23041417 DOI: 10.1016/J.Jconrel.2012.09.011 |
0.729 |
|
| 2012 |
Singh Y, Gao D, Gu Z, Li S, Rivera KA, Stein S, Love S, Sinko PJ. Influence of molecular size on the retention of polymeric nanocarrier diagnostic agents in breast ducts. Pharmaceutical Research. 29: 2377-88. PMID 22569800 DOI: 10.1007/S11095-012-0763-Z |
0.625 |
|
| 2012 |
Singh Y, Gao D, Gu Z, Li S, Stein S, Sinko PJ. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors. Molecular Pharmaceutics. 9: 144-55. PMID 22077582 DOI: 10.1021/Mp2003913 |
0.647 |
|
| 2011 |
Weinberger B, Laskin JD, Sunil VR, Sinko PJ, Heck DE, Laskin DL. Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. Pulmonary Pharmacology & Therapeutics. 24: 92-9. PMID 20851203 DOI: 10.1016/J.Pupt.2010.09.004 |
0.308 |
|
| 2010 |
Kutscher HL, Chao P, Deshmukh M, Sundara Rajan S, Singh Y, Hu P, Joseph LB, Stein S, Laskin DL, Sinko PJ. Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats. International Journal of Pharmaceutics. 402: 64-71. PMID 20883756 DOI: 10.1016/J.Ijpharm.2010.09.020 |
0.773 |
|
| 2010 |
Deshmukh M, Singh Y, Gunaseelan S, Gao D, Stein S, Sinko PJ. Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism. Biomaterials. 31: 6675-84. PMID 20561680 DOI: 10.1016/J.Biomaterials.2010.05.021 |
0.653 |
|
| 2010 |
Deshmukh M, Chao P, Kutscher HL, Gao D, Sinko PJ. A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. Journal of Medicinal Chemistry. 53: 1038-47. PMID 20063889 DOI: 10.1021/Jm901029N |
0.77 |
|
| 2010 |
Kutscher HL, Chao P, Deshmukh M, Singh Y, Hu P, Joseph LB, Reimer DC, Stein S, Laskin DL, Sinko PJ. Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. Journal of Controlled Release : Official Journal of the Controlled Release Society. 143: 31-7. PMID 20043961 DOI: 10.1016/J.Jconrel.2009.12.019 |
0.762 |
|
| 2010 |
Chao P, Deshmukh M, Kutscher HL, Gao D, Rajan SS, Hu P, Laskin DL, Stein S, Sinko PJ. Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model. Anti-Cancer Drugs. 21: 65-76. PMID 19966540 DOI: 10.1097/Cad.0B013E328332A322 |
0.77 |
|
| 2010 |
Gunaseelan S, Gunaseelan K, Deshmukh M, Zhang X, Sinko PJ. Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs. Advanced Drug Delivery Reviews. 62: 518-31. PMID 19941919 DOI: 10.1016/J.Addr.2009.11.021 |
0.331 |
|
| 2010 |
Anumolu SS, DeSantis AS, Menjoge AR, Hahn RA, Beloni JA, Gordon MK, Sinko PJ. Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds. Biomaterials. 31: 964-74. PMID 19853296 DOI: 10.1016/J.Biomaterials.2009.10.010 |
0.308 |
|
| 2010 |
Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL, Laskin JD. Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 114: 5-19. PMID 19833738 DOI: 10.1093/Toxsci/Kfp253 |
0.326 |
|
| 2009 |
Gunaseelan S, Pooyan S, Chen P, Samizadeh M, Palombo MS, Stein S, Zhang X, Sinko PJ. Multimeric peptide-based PEG nanocarriers with programmable elimination properties. Biomaterials. 30: 5649-59. PMID 19647312 DOI: 10.1016/J.Biomaterials.2009.05.068 |
0.483 |
|
| 2009 |
Deshmukh M, Kutscher H, Stein S, Sinko P. Nonenzymatic, self-elimination degradation mechanism of glutathione. Chemistry & Biodiversity. 6: 527-39. PMID 19353534 DOI: 10.1002/Cbdv.200800277 |
0.736 |
|
| 2009 |
Anumolu SS, Singh Y, Gao D, Stein S, Sinko PJ. Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response. Journal of Controlled Release : Official Journal of the Controlled Release Society. 137: 152-9. PMID 19341773 DOI: 10.1016/J.Jconrel.2009.03.016 |
0.682 |
|
| 2009 |
Zhang X, Jin Y, Plummer MR, Pooyan S, Gunaseelan S, Sinko PJ. Endocytosis and membrane potential are required for HeLa cell uptake of R.I.-CKTat9, a retro-inverso Tat cell penetrating peptide. Molecular Pharmaceutics. 6: 836-48. PMID 19278221 DOI: 10.1021/Mp800121F |
0.33 |
|
| 2009 |
Palombo MS, Singh Y, Sinko PJ. Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy Journal of Drug Delivery Science and Technology. 19: 3-14. DOI: 10.1016/S1773-2247(09)50001-9 |
0.673 |
|
| 2008 |
Singh Y, Palombo M, Sinko PJ. Recent trends in targeted anticancer prodrug and conjugate design. Current Medicinal Chemistry. 15: 1802-26. PMID 18691040 DOI: 10.2174/092986708785132997 |
0.69 |
|
| 2008 |
Usansky HH, Hu P, Sinko PJ. Differential roles of P-glycoprotein, multidrug resistance-associated protein 2, and CYP3A on saquinavir oral absorption in Sprague-Dawley rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 863-9. PMID 18256206 DOI: 10.1124/Dmd.107.017483 |
0.801 |
|
| 2008 |
Vortherms AR, Doyle RP, Gao D, Debrah O, Sinko PJ. Synthesis, characterization, and in vitro assay of folic acid conjugates of 3'-azido-3'-deoxythymidine (AZT): toward targeted AZT based anticancer therapeutics. Nucleosides, Nucleotides & Nucleic Acids. 27: 173-85. PMID 18205071 DOI: 10.1080/15257770701795946 |
0.316 |
|
| 2008 |
Wan L, Zhang X, Pooyan S, Palombo MS, Leibowitz MJ, Stein S, Sinko PJ. Optimizing size and copy number for PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarrier uptake by macrophages. Bioconjugate Chemistry. 19: 28-38. PMID 18092743 DOI: 10.1021/Bc070066K |
0.512 |
|
| 2007 |
Su Y, Hu P, Lee SH, Sinko PJ. Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 10: 519-36. PMID 18261372 DOI: 10.18433/J3Qp4W |
0.674 |
|
| 2007 |
Wan L, Pooyan S, Hu P, Leibowitz MJ, Stein S, Sinko PJ. Peritoneal macrophage uptake, pharmacokinetics and biodistribution of macrophage-targeted PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarriers for improving HIV drug delivery. Pharmaceutical Research. 24: 2110-9. PMID 17701325 DOI: 10.1007/S11095-007-9402-5 |
0.467 |
|
| 2007 |
Su Y, Zhang X, Sinko PJ. Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: a promising new approach to the treatment of multidrug resistant cancer. Cancer Letters. 253: 115-23. PMID 17349740 DOI: 10.1016/J.Canlet.2007.01.018 |
0.574 |
|
| 2006 |
Su Y, Lee SH, Sinko PJ. Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 29: 102-10. PMID 16844360 DOI: 10.1016/J.Ejps.2006.06.001 |
0.69 |
|
| 2006 |
Lalloo A, Chao P, Hu P, Stein S, Sinko PJ. Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins. Journal of Controlled Release : Official Journal of the Controlled Release Society. 112: 333-42. PMID 16650910 DOI: 10.1016/J.Jconrel.2006.03.002 |
0.791 |
|
| 2006 |
Su Y, Sinko PJ. Drug delivery across the blood-brain barrier: why is it difficult? how to measure and improve it? Expert Opinion On Drug Delivery. 3: 419-35. PMID 16640501 DOI: 10.1517/17425247.3.3.419 |
0.607 |
|
| 2006 |
Wan L, Zhang X, Gunaseelan S, Pooyan S, Debrah O, Leibowitz MJ, Rabson AB, Stein S, Sinko PJ. Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects. Aids Research and Therapy. 3: 12. PMID 16635263 DOI: 10.1186/1742-6405-3-12 |
0.508 |
|
| 2006 |
Lee SH, Sinko PJ. siRNA--getting the message out. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 27: 401-10. PMID 16442784 DOI: 10.1016/J.Ejps.2005.12.002 |
0.605 |
|
| 2005 |
Dharap SS, Wang Y, Chandna P, Khandare JJ, Qiu B, Gunaseelan S, Sinko PJ, Stein S, Farmanfarmaian A, Minko T. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide Proceedings of the National Academy of Sciences of the United States of America. 102: 12962-12967. PMID 16123131 DOI: 10.1073/Pnas.0504274102 |
0.401 |
|
| 2005 |
Park S, Sinko PJ. The blood-brain barrier sodium-dependent multivitamin transporter: a molecular functional in vitro-in situ correlation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1547-54. PMID 16033951 DOI: 10.1124/Dmd.105.005231 |
0.604 |
|
| 2005 |
Paranjpe PV, Stein S, Sinko PJ. Tumor-targeted and activated bioconjugates for improved camptothecin delivery. Anti-Cancer Drugs. 16: 763-75. PMID 16027527 DOI: 10.1097/01.Cad.0000172834.78068.7C |
0.782 |
|
| 2005 |
Bhardwaj RK, Herrera-Ruiz D, Sinko PJ, Gudmundsson OS, Knipp G. Delineation of human peptide transporter 1 (hPepT1)-mediated uptake and transport of substrates with varying transporter affinities utilizing stably transfected hPepT1/Madin-Darby canine kidney clones and Caco-2 cells. The Journal of Pharmacology and Experimental Therapeutics. 314: 1093-100. PMID 15901802 DOI: 10.1124/Jpet.105.087148 |
0.372 |
|
| 2005 |
Usansky HH, Sinko PJ. Estimating human drug oral absorption kinetics from Caco-2 permeability using an absorption-disposition model: model development and evaluation and derivation of analytical solutions for k(a) and F(a). The Journal of Pharmacology and Experimental Therapeutics. 314: 391-9. PMID 15833900 DOI: 10.1124/Jpet.104.076182 |
0.789 |
|
| 2005 |
Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular Pharmacology. 67: 868-76. PMID 15576633 DOI: 10.1124/Mol.104.007583 |
0.317 |
|
| 2005 |
Park S, Sinko PJ. P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice. The Journal of Pharmacology and Experimental Therapeutics. 312: 1249-56. PMID 15528451 DOI: 10.1124/Jpet.104.076216 |
0.565 |
|
| 2004 |
Zhang X, Wan L, Pooyan S, Su Y, Gardner CR, Leibowitz MJ, Stein S, Sinko PJ. Quantitative assessment of the cell penetrating properties of RI-Tat-9: evidence for a cell type-specific barrier at the plasma membrane of epithelial cells. Molecular Pharmaceutics. 1: 145-55. PMID 15832511 DOI: 10.1021/Mp034014Y |
0.651 |
|
| 2004 |
Su Y, Zhang X, Sinko PJ. Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Molecular Pharmaceutics. 1: 49-56. PMID 15832500 DOI: 10.1021/Mp0340136 |
0.605 |
|
| 2004 |
Gunaseelan S, Debrah O, Wan L, Leibowitz MJ, Rabson AB, Stein S, Sinko PJ. Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay. Bioconjugate Chemistry. 15: 1322-33. PMID 15546199 DOI: 10.1021/Bc0498875 |
0.468 |
|
| 2004 |
Paranjpe PV, Chen Y, Kholodovych V, Welsh W, Stein S, Sinko PJ. Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation. Journal of Controlled Release : Official Journal of the Controlled Release Society. 100: 275-92. PMID 15544875 DOI: 10.1016/J.Jconrel.2004.08.030 |
0.787 |
|
| 2004 |
Kunta JR, Lee SH, Perry BA, Lee YH, Sinko PJ. Differentiation of gut and hepatic first-pass loss of verapamil in intestinal and vascular access-ported (IVAP) rabbits. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1293-8. PMID 15304428 DOI: 10.1124/Dmd.104.000752 |
0.791 |
|
| 2004 |
Su Y, Lee SH, Sinko PJ. Practical aspects of transporter model systems: a case study involving SQV. Drug Metabolism Reviews. 36: 377-89. PMID 15237860 DOI: 10.1081/Dmr-120037570 |
0.721 |
|
| 2004 |
Lalloo AK, Luo FR, Guo A, Paranjpe PV, Lee SH, Vyas V, Rubin E, Sinko PJ. Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2). Bmc Medicine. 2: 16. PMID 15125776 DOI: 10.1186/1741-7015-2-16 |
0.749 |
|
| 2004 |
Sinko PJ, Kunta JR, Usansky HH, Perry BA. Differentiation of gut and hepatic first pass metabolism and secretion of saquinavir in ported rabbits. The Journal of Pharmacology and Experimental Therapeutics. 310: 359-66. PMID 15004217 DOI: 10.1124/Jpet.103.064394 |
0.764 |
|
| 2004 |
Kunta JR, Sinko PJ. Intestinal drug transporters: in vivo function and clinical importance. Current Drug Metabolism. 5: 109-24. PMID 14965254 DOI: 10.2174/1389200043489144 |
0.8 |
|
| 2003 |
Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochemical and Biophysical Research Communications. 310: 222-7. PMID 14511674 DOI: 10.1016/J.Bbrc.2003.09.007 |
0.565 |
|
| 2003 |
Williams GC, Knipp GT, Sinko PJ. The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hMDR1. Journal of Pharmaceutical Sciences. 92: 1957-67. PMID 14502536 DOI: 10.1002/Jps.10458 |
0.313 |
|
| 2003 |
Dharap SS, Qiu B, Williams GC, Sinko P, Stein S, Minko T. Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides. Journal of Controlled Release : Official Journal of the Controlled Release Society. 91: 61-73. PMID 12932638 DOI: 10.1016/S0168-3659(03)00209-8 |
0.35 |
|
| 2003 |
Usansky HH, Sinko PJ. Computation of log BB values for compounds transported through carrier-mediated mechanisms using in vitro permeability data from brain microvessel endothelial cell (BMEC) monolayers. Pharmaceutical Research. 20: 390-6. PMID 12669958 DOI: 10.1023/A:1022647903205 |
0.769 |
|
| 2003 |
Qiu B, Stefanos S, Ma J, Lalloo A, Perry BA, Leibowitz MJ, Sinko PJ, Stein S. A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: a new biomaterial for protein drug delivery. Biomaterials. 24: 11-8. PMID 12417173 DOI: 10.1016/S0142-9612(02)00227-2 |
0.781 |
|
| 2003 |
Paranjpe PV, Grass GM, Sinko PJ. In Silico Tools for Drug Absorption Prediction American Journal of Drug Delivery. 1: 133-148. DOI: 10.2165/00137696-200301020-00005 |
0.782 |
|
| 2002 |
Williams GC, Liu A, Knipp G, Sinko PJ. Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrobial Agents and Chemotherapy. 46: 3456-62. PMID 12384350 DOI: 10.1128/Aac.46.11.3456-3462.2002 |
0.349 |
|
| 2002 |
Minko T, Paranjpe PV, Qiu B, Lalloo A, Won R, Stein S, Sinko PJ. Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. Cancer Chemotherapy and Pharmacology. 50: 143-50. PMID 12172980 DOI: 10.1007/S00280-002-0463-1 |
0.772 |
|
| 2002 |
Luo FR, Paranjpe PV, Guo A, Rubin E, Sinko P. Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 763-70. PMID 12065434 DOI: 10.1124/Dmd.30.7.763 |
0.794 |
|
| 2002 |
Grass GM, Sinko PJ. Physiologically-based pharmacokinetic simulation modelling. Advanced Drug Delivery Reviews. 54: 433-51. PMID 11922957 DOI: 10.1016/S0169-409X(02)00013-3 |
0.353 |
|
| 2002 |
Pooyan S, Qiu B, Chan MM, Fong D, Sinko PJ, Leibowitz MJ, Stein S. Conjugates bearing multiple formyl-methionyl peptides display enhanced binding to but not activation of phagocytic cells. Bioconjugate Chemistry. 13: 216-23. PMID 11906258 DOI: 10.1021/Bc0100657 |
0.322 |
|
| 2002 |
Guo A, Marinaro W, Hu P, Sinko PJ. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 457-63. PMID 11901101 DOI: 10.1124/Dmd.30.4.457 |
0.393 |
|
| 2002 |
Paranjpe PV, Sinko PJ. Overcoming paracellular tissue barriers for drug delivery Pharmaceutical News. 9: 381-395. |
0.787 |
|
| 2001 |
Kunta JR, Perry BA, Sutyak JP, Sinko PJ. Development of a novel intestinal and vascular access port (IVAP) rabbit model to study regiospecific oral absorption pharmacokinetics. Comparative Medicine. 51: 349-56. PMID 11924794 |
0.779 |
|
| 2001 |
Lee YH, Perry BA, Lee HS, Kunta JR, Sutyak JP, Sinko PJ. Differentiation of gut and hepatic first-pass effect of drugs: 1. Studies of verapamil in ported dogs. Pharmaceutical Research. 18: 1721-8. PMID 11785692 DOI: 10.1023/A:1013374630274 |
0.775 |
|
| 2001 |
Ramanathan S, Qiu B, Pooyan S, Zhang G, Stein S, Leibowitz MJ, Sinko PJ. Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide. Journal of Controlled Release : Official Journal of the Controlled Release Society. 77: 199-212. PMID 11733088 DOI: 10.1016/S0168-3659(01)00474-6 |
0.587 |
|
| 2001 |
Ramanathan S, Pooyan S, Stein S, Prasad PD, Wang J, Leibowitz MJ, Ganapathy V, Sinko PJ. Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. Pharmaceutical Research. 18: 950-6. PMID 11496954 DOI: 10.1023/A:1010932126662 |
0.593 |
|
| 2001 |
Gupta E, Vyas V, Ahmed F, Sinko P, Cook T, Rubin E. Pharmacokinetics of orally administered camptothecins. Annals of the New York Academy of Sciences. 922: 195-204. PMID 11193895 DOI: 10.1111/J.1749-6632.2000.Tb07038.X |
0.37 |
|
| 2001 |
Grass GM, Sinko PJ. Effect of diverse datasets on the predictive capability of ADME models in drug discovery Drug Discovery Today. 6. DOI: 10.1016/S1359-6446(01)00150-7 |
0.34 |
|
| 2000 |
Balimane PV, Sinko PJ. Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cells Biopharmaceutics and Drug Disposition. 21: 165-174. PMID 11180195 DOI: 10.1002/1099-081X(200007)21:5<165::Aid-Bdd225>3.0.Co;2-F |
0.334 |
|
| 2000 |
Kunta J, Yan J, Makhey VD, Sinko PJ. Active efflux kinetics of etoposide from rabbit small intestine and colon Biopharmaceutics and Drug Disposition. 21: 83-93. PMID 11113881 DOI: 10.1002/1099-081X(200004)21:3<83::Aid-Bdd220>3.0.Co;2-J |
0.785 |
|
| 2000 |
Lee YH, Sinko PJ. Oral delivery of salmon calcitonin Advanced Drug Delivery Reviews. 42: 225-238. PMID 10963837 DOI: 10.1016/S0169-409X(00)00063-6 |
0.399 |
|
| 2000 |
Hee Lee Y, Leesman GD, Makhey V, Yu H, Hu P, Perry B, Sutyak JP, Wagner EJ, Falzone LM, Stern W, Sinko PJ. Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 50: 205-11. PMID 10962228 DOI: 10.1016/S0939-6411(00)00102-8 |
0.331 |
|
| 2000 |
Lee YH, Perry BA, Sutyak JP, Stern W, Sinko PJ. Regional differences in intestinal spreading and pH recovery and the impact on salmon calcitonin absorption in dogs Pharmaceutical Research. 17: 284-290. PMID 10801216 DOI: 10.1023/A:1007596821702 |
0.367 |
|
| 2000 |
Norris DA, Leesman GD, Sinko PJ, Grass GM. Development of predictive pharmacokinetic simulation models for drug discovery Journal of Controlled Release. 65: 55-62. PMID 10699270 DOI: 10.1016/S0168-3659(99)00232-1 |
0.368 |
|
| 1999 |
Williams GC, Sinko PJ. Oral absorption of the HIV protease inhibitors: a current update. Advanced Drug Delivery Reviews. 39: 211-238. PMID 10837775 DOI: 10.1016/S0169-409X(99)00027-7 |
0.353 |
|
| 1999 |
Lee YH, Perry BA, Labruno S, Lee HS, Stern W, Falzone LM, Sinko PJ. Impact of regional intestinal pH modulation on absorption of peptide drugs: Oral absorption studies of salmon calcitonin in beagle dogs Pharmaceutical Research. 16: 1233-1239. PMID 10468025 DOI: 10.1023/A:1014849630520 |
0.336 |
|
| 1999 |
Sinko PJ, Lee YH, Makhey V, Leesman GD, Sutyak JP, Yu H, Perry B, Smith CL, Hu P, Wagner EJ, Falzone LM, McWhorter LT, Gilligan JP, Stern W. Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT). Pharmaceutical Research. 16: 527-33. PMID 10227707 DOI: 10.1023/A:1018819012405 |
0.313 |
|
| 1999 |
Balimane PV, Sinko PJ. Involvement of multiple transporters in the oral absorption of nucleoside analogues Advanced Drug Delivery Reviews. 39: 183-209. DOI: 10.1016/S0169-409X(99)00026-5 |
0.37 |
|
| 1998 |
Balimane PV, Tamai I, Guo A, Nakanishi T, Kitada H, Leibach FH, Tsuji A, Sinko PJ. Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir Biochemical and Biophysical Research Communications. 250: 246-251. PMID 9753615 DOI: 10.1006/Bbrc.1998.9298 |
0.338 |
|
| 1998 |
Makhey VD, Guo A, Norris DA, Hu P, Yan J, Sinko PJ. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells Pharmaceutical Research. 15: 1160-1167. PMID 9706044 DOI: 10.1023/A:1011971303880 |
0.4 |
|
| 1998 |
Sinko PJ, Balimane PV. Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: 1. Interactions with peptides, organic anions and organic cations in rats Biopharmaceutics and Drug Disposition. 19: 209-217. PMID 9604120 DOI: 10.1002/(Sici)1099-081X(199805)19:4<209::Aid-Bdd93>3.0.Co;2-O |
0.378 |
|
| 1998 |
Norris DA, Puri N, Sinko PJ. The effect of physical barriers and properties on the oral absorption of particulates Advanced Drug Delivery Reviews. 34: 135-154. DOI: 10.1016/S0169-409X(98)00037-4 |
0.333 |
|
| 1997 |
Yu H, Sinko PJ. Influence of the microporous substratum and hydrodynamics on resistances to drug transport in cell culture systems: Calculation of intrinsic transport parameters Journal of Pharmaceutical Sciences. 86: 1448-1457. PMID 9423161 DOI: 10.1021/Js960524Q |
0.376 |
|
| 1997 |
Sinko PJ, Sutyak JP, Leesman GD, Peidi HU, Makhey VD, Hongshi YU, Smith CL. Oral absorption of anti-aids nucleoside analogues: 3. Regional absorption and in vivo permeability of 2', 3'-dideoxyinosine in an intestinal-vascular access port (IVAP) dog model Biopharmaceutics and Drug Disposition. 18: 697-710. PMID 9373726 DOI: 10.1002/(Sici)1099-081X(199711)18:8<697::Aid-Bdd57>3.0.Co;2-Z |
0.344 |
|
| 1997 |
Yu H, Cook TJ, Sinko PJ. Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages. Pharmaceutical Research. 14: 757-62. PMID 9210193 DOI: 10.1023/A:1012150405949 |
0.342 |
|
| 1996 |
Waclawski AP, Sinko PJ. Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogues. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations Journal of Pharmaceutical Sciences. 85: 478-485. PMID 8742938 DOI: 10.1021/Js950363A |
0.375 |
|
| 1996 |
Sinko PJ, Leesman GD, Waclawski AP, Yu H, Kou JH. Analysis of intestinal perfusion data for highly permeable drugs using a numerical aqueous resistance - Nonlinear regression method Pharmaceutical Research. 13: 570-576. PMID 8710748 DOI: 10.1023/A:1016098121784 |
0.356 |
|
| 1995 |
Sinko PJ, Hu P, Waclawski AP, Patel NR. Oral absorption of anti‐aids nucleoside analogues. 1. Intestinal transport of didanosine in rat and rabbit preparations Journal of Pharmaceutical Sciences. 84: 959-965. PMID 7500281 DOI: 10.1002/Jps.2600840811 |
0.368 |
|
| 1994 |
Sinko PJ, Patel NR, Hu P. Site-specific oral absorption of didanosine: in situ characterization and correlation with extent of absorption in vivo International Journal of Pharmaceutics. 109: 125-133. DOI: 10.1016/0378-5173(94)90140-6 |
0.358 |
|
| 1993 |
Sinko PJ, Leesman GD, Amidon GL. Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 271-275. PMID 8456076 DOI: 10.1023/A:1018999130076 |
0.517 |
|
| 1993 |
Oh DM, Sinko PJ, Amidon GL. Characterization of the oral absorption of some β-lactams: Effect of the α-amino side chain group Journal of Pharmaceutical Sciences. 82: 897-900. PMID 8229687 DOI: 10.1002/Jps.2600820907 |
0.521 |
|
| 1992 |
Doo-Man Oh, Sinko PJ, Amidon GL. Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ International Journal of Pharmaceutics. 85: 181-187. PMID 11537280 DOI: 10.1016/0378-5173(92)90147-T |
0.472 |
|
| 1991 |
Sinko PJ, Leesman GD, Amidon GL. Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 979-988. PMID 1924168 DOI: 10.1023/A:1015892621261 |
0.518 |
|
| 1989 |
Sinko PJ, Amidon GL. Characterization of the oral absorption of β-lactam antibiotics II: Competitive absorption and peptide carrier specificity Journal of Pharmaceutical Sciences. 78: 723-727. PMID 2585263 DOI: 10.1002/Jps.2600780904 |
0.508 |
|
| 1988 |
Hu M, Sinko PJ, deMeere AL, Johnson DA, Amidon GL. Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach. Journal of Theoretical Biology. 131: 107-14. PMID 3419188 DOI: 10.1016/S0022-5193(88)80124-3 |
0.447 |
|
| 1988 |
Amidon GL, Sinko PJ, Fleisher D. Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 651-654. PMID 3244618 DOI: 10.1023/A:1015927004752 |
0.553 |
|
| 1988 |
Sinko PJ, Amidon GL. Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 645-650. PMID 3244617 DOI: 10.1023/A:1015974920682 |
0.459 |
|
| 1987 |
Sinko PJ, Ming Hu, Amidon GL. Carrier mediated transport of amino acids, small peptides, and their drug analogs Journal of Controlled Release. 6: 115-121. DOI: 10.1016/0168-3659(87)90069-1 |
0.519 |
|
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