Lee-Yuan Liu-Chen - Publications

Affiliations: 
Temple University, Philadelphia, PA, United States 
Area:
Opioid receptors, Pharmacology
Website:
http://www.temple.edu/medicine/faculty/l/liuchenl.asp?pms=(Liu-Chen%20L%5Bau%5D%20Temple%20University%5Baffiliation%5D)

170 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Obeng S, Jali A, Zheng Y, Wang H, Schwienteck K, Chen C, Stevens DL, Akbarali H, Dewey WL, Banks ML, Liu-Chen LY, Selley DE, Zhang Y. Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment. Acs Chemical Neuroscience. PMID 30758946 DOI: 10.1021/acschemneuro.9b00038  0.48
2018 Liu JJ, Chiu YT, DiMattio KM, Chen C, Huang P, Gentile TA, Muschamp JW, Cowan A, Mann M, Liu-Chen LY. Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30082888 DOI: 10.1038/s41386-018-0155-0  0.48
2018 Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu-Chen LY, Schwarzer C, Mann M. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science (New York, N.Y.). 360. PMID 29930108 DOI: 10.1126/science.aao4927  0.48
2018 Hicks C, Huang P, Ramos L, Nayak SU, Caro Y, Reitz AB, Smith GR, Lee DY, Rawls SM, Liu-Chen LY. Dopamine D1-like receptor agonist and D2-like receptor antagonist (-)-Stepholidine reduces reinstatement of drug-seeking behavior for 3,4-methylenedioxypyrovalerone (MDPV) in rats. Acs Chemical Neuroscience. PMID 29597343 DOI: 10.1021/acschemneuro.7b00510  0.4
2017 Chiu YT, Chen C, Yu D, Schulz S, Liu-Chen LY. Agonist-dependent and -independent kappa opioid receptor phosphorylation showed distinct phosphorylation patterns and resulted in different cellular outcomes. Molecular Pharmacology. PMID 28893975 DOI: 10.1124/mol.117.108555  0.48
2017 Lee DY, Liu J, Zhang S, Huang P, Liu-Chen LY. Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. Bioorganic & Medicinal Chemistry Letters. PMID 28214075 DOI: 10.1016/j.bmcl.2017.01.090  0.4
2017 Xu W, Wang X, Tocker AM, Huang P, Reith ME, Liu-Chen LY, Smith AB, Kortagere S. Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists. Acs Chemical Neuroscience. 8: 486-500. PMID 27801563 DOI: 10.1021/acschemneuro.6b00221  0.4
2016 Wang XF, Barbier E, Chiu YT, He Y, Zhan J, Bi GH, Zhang HY, Feng B, Liu-Chen LY, Wang JB, Xi ZX. T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10392-10403. PMID 27707973 DOI: 10.1523/JNEUROSCI.0603-16.2016  0.96
2016 Abdallah IA, Huang P, Liu J, Lee DY, Liu-Chen LY, Hassan HE. Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine (L-THP) and its metabolites in plasma and brain tissues: application to a pharmacokinetic study. Biomedical Chromatography : Bmc. PMID 27606501 DOI: 10.1002/bmc.3850  0.4
2016 Kutlu MG, Oliver C, Huang P, Liu-Chen LY, Gould TJ. Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation. Neuropharmacology. PMID 27378334 DOI: 10.1016/j.neuropharm.2016.06.032  0.96
2016 Huang P, Tunis J, Parry C, Tallarida R, Liu-Chen LY. Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test. European Journal of Pharmacology. PMID 27044434 DOI: 10.1016/j.ejphar.2016.03.061  0.96
2016 Huang P, Yakovleva T, Aldrich JV, Tunis J, Parry C, Liu-Chen LY. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neuroscience Letters. PMID 26780565 DOI: 10.1016/j.neulet.2016.01.017  0.96
2015 Chen C, Chiu YT, Wu W, Huang P, Mann A, Schulz S, Liu-Chen LY. Determination of sites of U50,488H-promoted phosphorylation of the mouse kappa opioid receptor (KOPR): Disconnect between KOPR phosphorylation and internalization. The Biochemical Journal. PMID 26635353 DOI: 10.1042/BJ20141471  0.96
2015 Lee DY, Deng G, Ma Z, Xu W, Yang L, Liu J, Dai R, Liu-Chen LY. Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists. Bioorganic & Medicinal Chemistry Letters. PMID 26330078 DOI: 10.1016/j.bmcl.2015.06.092  0.96
2015 DiMattio KM, Ehlert FJ, Liu-Chen LY. Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors. European Journal of Pharmacology. 761: 235-44. PMID 26057692 DOI: 10.1016/j.ejphar.2015.05.054  0.96
2015 DiMattio KM, Chen C, Shi L, Liu-Chen LY. K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA). European Journal of Pharmacology. 748: 93-100. PMID 25481857 DOI: 10.1016/j.ejphar.2014.11.028  0.96
2015 Huang P, Chen C, Liu-Chen LY. Detection of mu opioid receptor (MOPR) and its glycosylation in rat and mouse brains by western blot with anti-μC, an affinity-purified polyclonal anti-MOPR antibody. Methods in Molecular Biology (Clifton, N.J.). 1230: 141-54. PMID 25293322 DOI: 10.1007/978-1-4939-1708-2_11  0.96
2015 Chen C, Huang P, Liu-Chen LY. Identification and verification of proteins interacting with the kappa opioid receptor (KOPR). Methods in Molecular Biology (Clifton, N.J.). 1230: 129-40. PMID 25293321 DOI: 10.1007/978-1-4939-1708-2_10  0.96
2014 Dimattio KM, Yakovleva TV, Aldrich JV, Cowan A, Liu-Chen LY. Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice. Neuroscience Letters. 563: 155-9. PMID 24503508 DOI: 10.1016/j.neulet.2014.01.022  0.96
2014 Wang YJ, Huang P, Blendy JA, Liu-Chen LY. Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G. Addiction Biology. 19: 354-61. PMID 22862850 DOI: 10.1111/j.1369-1600.2012.00484.x  0.96
2013 Munro TA, Xu W, Ho DM, Liu-Chen LY, Cohen BM. Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity. Beilstein Journal of Organic Chemistry. 9: 2916-24. PMID 24454571 DOI: 10.3762/bjoc.9.328  0.96
2013 Xu W, Wang Y, Ma Z, Chiu YT, Huang P, Rasakham K, Unterwald E, Lee DY, Liu-Chen LY. L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors. Drug and Alcohol Dependence. 133: 693-703. PMID 24080315 DOI: 10.1016/j.drugalcdep.2013.08.021  0.96
2013 Huang P, Chiu YT, Chen C, Wang Y, Liu-Chen LY. A G protein-coupled receptor (GPCR) in red: live cell imaging of the kappa opioid receptor-tdTomato fusion protein (KOPR-tdT) in neuronal cells. Journal of Pharmacological and Toxicological Methods. 68: 340-5. PMID 23856011 DOI: 10.1016/j.vascn.2013.07.002  0.96
2013 Xu W, Chen C, Li JG, Dimattio K, Wang Y, Unterwald E, Liu-Chen LY. PKA and ERK1/2 are involved in dopamine D₁ receptor-induced heterologous desensitization of the δ opioid receptor. Life Sciences. 92: 1101-9. PMID 23624231 DOI: 10.1016/j.lfs.2013.04.006  0.96
2013 Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1585-97. PMID 23446450 DOI: 10.1038/npp.2013.58  0.96
2012 Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C. Ligand directed signaling differences between rodent and human κ-opioid receptors. The Journal of Biological Chemistry. 287: 41595-607. PMID 23086943 DOI: 10.1074/jbc.M112.381368  0.96
2012 Li JG, Chen C, Huang P, Wang Y, Liu-Chen LY. 14-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR). The Journal of Biological Chemistry. 287: 37778-92. PMID 22989890 DOI: 10.1074/jbc.M112.359679  0.96
2012 Rasakham K, McGillivray KL, Liu-Chen LY. Sex differences in U50,488H-induced phosphorylation of p44/42 mitogen-activated protein kinase in the guinea pig brain. Neuroscience. 223: 447-56. PMID 22863678 DOI: 10.1016/j.neuroscience.2012.07.040  0.96
2012 Rives ML, Rossillo M, Liu-Chen LY, Javitch JA. 6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment. The Journal of Biological Chemistry. 287: 27050-4. PMID 22736766 DOI: 10.1074/jbc.C112.387332  0.96
2012 Lisek R, Xu W, Yuvasheva E, Chiu YT, Reitz AB, Liu-Chen LY, Rawls SM. Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug and Alcohol Dependence. 126: 257-62. PMID 22652295 DOI: 10.1016/j.drugalcdep.2012.04.021  0.96
2012 Wang YJ, Huang P, Ung A, Blendy JA, Liu-Chen LY. Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience. 205: 178-84. PMID 22240251 DOI: 10.1016/j.neuroscience.2011.12.033  0.96
2012 Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA, Cohen BM. Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorganic & Medicinal Chemistry Letters. 22: 1023-6. PMID 22204910 DOI: 10.1016/j.bmcl.2011.11.128  0.96
2012 Huang P, Chen C, Mague SD, Blendy JA, Liu-Chen LY. A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. The Biochemical Journal. 441: 379-86. PMID 21864297 DOI: 10.1042/BJ20111050  0.96
2011 Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen LY. Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig. The Journal of Pharmacology and Experimental Therapeutics. 339: 438-50. PMID 21841040 DOI: 10.1124/jpet.111.183905  0.96
2011 Zhu J, Spencer TJ, Liu-Chen LY, Biederman J, Bhide PG. Methylphenidate and μ opioid receptor interactions: a pharmacological target for prevention of stimulant abuse. Neuropharmacology. 61: 283-92. PMID 21545805 DOI: 10.1016/j.neuropharm.2011.04.015  0.96
2011 Chen C, Wang Y, Huang P, Liu-Chen LY. Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression. The Journal of Biological Chemistry. 286: 15106-15. PMID 21388957 DOI: 10.1074/jbc.M111.230896  0.96
2011 Rasakham K, Liu-Chen LY. Sex differences in kappa opioid pharmacology. Life Sciences. 88: 2-16. PMID 20951148 DOI: 10.1016/j.lfs.2010.10.007  0.96
2010 Lee DY, Yang L, Xu W, Deng G, Guo L, Liu-Chen LY. Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A. Bioorganic & Medicinal Chemistry Letters. 20: 5749-52. PMID 20801035 DOI: 10.1016/j.bmcl.2010.08.001  0.96
2010 Huang P, Liu-Chen LY, Kirby LG. Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze. Neuroscience Letters. 475: 165-8. PMID 20363293 DOI: 10.1016/j.neulet.2010.03.071  0.96
2010 Woodruff-Pak DS, Lehr MA, Li JG, Liu-Chen LY. Young and older good learners have higher levels of brain nicotinic receptor binding. Neurobiology of Aging. 31: 1032-43. PMID 18950900 DOI: 10.1016/j.neurobiolaging.2008.09.002  0.96
2010 Ma Z, Deng G, Dai R, Xu W, Liu-Chen LY, Lee DYW. Thermal degradation products derived from the smoke of Salvia divinorum leaves Tetrahedron Letters. 51: 5480-5482. DOI: 10.1016/j.tetlet.2010.08.033  0.96
2010 Huang P, Liu-Chen LY. The brain dynorphins/kappa opioid receptor (DYN/KOPR) system plays a role in anxiety regulation Journal of Medical Sciences. 30: 135-139.  0.96
2009 Huang P, Liu-Chen LY, Unterwald EM, Cowan A. Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neuroscience Letters. 465: 66-70. PMID 19733208 DOI: 10.1016/j.neulet.2009.08.073  0.96
2009 Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA. Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proceedings of the National Academy of Sciences of the United States of America. 106: 10847-52. PMID 19528658 DOI: 10.1073/pnas.0901800106  0.96
2009 Huang P, Liu-Chen LY. Detecting the mu opioid receptor in brain following SDS-PAGE with multiple approaches. Frontiers in Bioscience (Elite Edition). 1: 220-7. PMID 19482639  0.96
2009 Wang Q, Liu-Chen LY, Traynor JR. Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. The Journal of Biological Chemistry. 284: 18357-67. PMID 19416973 DOI: 10.1074/jbc.M109.015453  0.96
2009 Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ. C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience. 159: 492-500. PMID 19373968 DOI: 10.1016/j.neuroscience.2009.01.031  0.96
2009 Chen Y, Liu-Chen LY. Chaperone-like effects of cell-permeant ligands on opioid receptors. Frontiers in Bioscience (Landmark Edition). 14: 634-43. PMID 19273091 DOI: 10.2741/3269  0.96
2009 Yang L, Xu W, Chen F, Liu-Chen LY, Ma Z, Lee DY. Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A. Bioorganic & Medicinal Chemistry Letters. 19: 1301-4. PMID 19211245 DOI: 10.1016/j.bmcl.2009.01.078  0.96
2009 Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor. Bioorganic & Medicinal Chemistry. 17: 1370-80. PMID 19147366 DOI: 10.1016/j.bmc.2008.12.012  0.96
2009 Wang Y, Xu W, Huang P, Chavkin C, Van Bockstaele EJ, Liu-Chen LY. Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord. Journal of Neuroscience Research. 87: 1695-702. PMID 19130621 DOI: 10.1002/jnr.21971  0.96
2009 Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY. GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. The Journal of Biological Chemistry. 284: 1673-85. PMID 19001416 DOI: 10.1074/jbc.M808303200  0.96
2009 Inan S, Lee DY, Liu-Chen LY, Cowan A. Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn-Schmiedeberg's Archives of Pharmacology. 379: 263-70. PMID 18925386 DOI: 10.1007/s00210-008-0358-8  0.96
2008 Wang Y, Van Bockstaele EJ, Liu-Chen LY. In vivo trafficking of endogenous opioid receptors. Life Sciences. 83: 693-9. PMID 18930741 DOI: 10.1016/j.lfs.2008.09.023  0.96
2008 Ma ZZ, Xu W, Jensen NH, Roth BL, Liu-Chen LY, Lee DY. Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules (Basel, Switzerland). 13: 2303-12. PMID 18830156 DOI: 10.3390/molecules13092303  0.96
2008 Xu W, Sanz A, Pardo L, Liu-Chen LY. Activation of the mu opioid receptor involves conformational rearrangements of multiple transmembrane domains. Biochemistry. 47: 10576-86. PMID 18778083 DOI: 10.1021/bi800381v  0.96
2008 Li JG, Lehr M, Liu-Chen LY, Woodruff-Pak DS. Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2820-30. PMID 18256594 DOI: 10.1038/npp.2008.1  0.96
2008 Li JG, Haines DS, Liu-Chen LY. Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation. Molecular Pharmacology. 73: 1319-30. PMID 18212250 DOI: 10.1124/mol.107.042846  0.96
2008 Ma Z, Xu W, Liu-Chen LY, Lee DY. Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorganic & Medicinal Chemistry. 16: 3218-23. PMID 18166466 DOI: 10.1016/j.bmc.2007.12.021  0.96
2008 Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY. 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. The Journal of Pharmacology and Experimental Therapeutics. 324: 1073-83. PMID 18089845 DOI: 10.1124/jpet.107.132142  0.96
2008 Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen LY, Carlezon WA, Cohen BM, Béguin C. Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorganic & Medicinal Chemistry. 16: 1279-86. PMID 17981041 DOI: 10.1016/j.bmc.2007.10.067  0.96
2008 Huang P, Chen C, Xu W, Yoon SI, Unterwald EM, Pintar JE, Wang Y, Chong PL, Liu-Chen LY. Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor. Biochemical and Biophysical Research Communications. 365: 82-8. PMID 17980152 DOI: 10.1016/j.bbrc.2007.10.128  0.96
2008 Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. The Journal of Pharmacology and Experimental Therapeutics. 324: 188-95. PMID 17951511 DOI: 10.1124/jpet.107.129023  0.96
2008 Béguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Corrigendum to "Synthesis and in vitro evaluation of salvinorin A analogues: Effect of configuration at C(2) and substitution at C(18)" [Bioorg. Med. Chem. Lett. 16 (2006) 4679-4685] (DOI:10.1016/j.bmcl.2006.05.093) Bioorganic and Medicinal Chemistry Letters. 18: 4448. DOI: 10.1016/j.bmcl.2008.06.021  0.96
2008 Lee DYW, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA, Cohen B. Corrigendum to "Synthesis and in vitro pharmacological studies of new C(4) modified salvinorin A analogues" [Bioorg. Med. Chem. Lett. 16 (2006) 5498-5502] (DOI:10.1016/j.bmcl.2006.08.051) Bioorganic and Medicinal Chemistry Letters. 18: 2227. DOI: 10.1016/j.bmcl.2008.02.005  0.96
2007 Huang P, Xu W, Yoon SI, Chen C, Chong PL, Unterwald EM, Liu-Chen LY. Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells. Brain Research. 1184: 46-56. PMID 17980352 DOI: 10.1016/j.brainres.2007.09.096  0.96
2007 Li JG, Chen C, Liu-Chen LY. N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. Biochemistry. 46: 10960-70. PMID 17711303 DOI: 10.1021/bi700443j  0.96
2007 Xie Z, Li Z, Guo L, Ye C, Li J, Yu X, Yang H, Wang Y, Chen C, Zhang D, Liu-Chen LY. Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors. European Journal of Pharmacology. 565: 45-53. PMID 17433292 DOI: 10.1016/j.ejphar.2007.03.005  0.96
2007 Chen Y, Chen C, Liu-Chen LY. Dynorphin peptides differentially regulate the human kappa opioid receptor. Life Sciences. 80: 1439-48. PMID 17316701 DOI: 10.1016/j.lfs.2007.01.018  0.96
2007 Munro TA, Duncan KK, Staples RJ, Xu W, Liu-Chen LY, Béguin C, Carlezon WA, Cohen BM. 8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptor. Beilstein Journal of Organic Chemistry. 3: 1. PMID 17212822 DOI: 10.1186/1860-5397-3-1  0.96
2007 Huang P, Xu W, Yoon SI, Chen C, Chong PL, Liu-Chen LY. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Biochemical Pharmacology. 73: 534-49. PMID 17141202 DOI: 10.1016/j.bcp.2006.10.032  0.96
2006 Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues. Bioorganic & Medicinal Chemistry Letters. 16: 5498-502. PMID 16945525 DOI: 10.1016/j.bmcl.2006.08.051  0.96
2006 Hummel M, Schroeder J, Liu-Chen LY, Cowan A, Unterwald EM. An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. Neuroscience. 142: 481-91. PMID 16893609 DOI: 10.1016/j.neuroscience.2006.06.013  0.96
2006 Chen Y, Chen C, Wang Y, Liu-Chen LY. Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists. The Journal of Pharmacology and Experimental Therapeutics. 319: 765-75. PMID 16882876 DOI: 10.1124/jpet.106.107987  0.96
2006 Béguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorganic & Medicinal Chemistry Letters. 16: 4679-85. PMID 16777411 DOI: 10.1016/j.bmcl.2006.05.093  0.96
2006 Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clinical Pharmacology and Therapeutics. 79: 461-79. PMID 16678548 DOI: 10.1016/j.clpt.2006.01.009  0.96
2006 Wang Y, Dun SL, Huang P, Chen C, Chen Y, Unterwald EM, Dun NJ, Van Bockstaele EJ, Liu-Chen LY. Distribution and ultrastructural localization of GEC1 in the rat CNS. Neuroscience. 140: 1265-76. PMID 16650615 DOI: 10.1016/j.neuroscience.2006.03.013  0.96
2006 Dun SL, Brailoiu E, Wang Y, Brailoiu GC, Liu-Chen LY, Yang J, Chang JK, Dun NJ. Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium. Endocrinology. 147: 3243-8. PMID 16601133 DOI: 10.1210/en.2006-0237  0.96
2006 Feng P, Rahim RT, Cowan A, Liu-Chen LY, Peng X, Gaughan J, Meissler JJ, Adler MW, Eisenstein TK. Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit. European Journal of Pharmacology. 534: 250-7. PMID 16513108 DOI: 10.1016/j.ejphar.2006.01.048  0.96
2006 Xu W, Yoon SI, Huang P, Wang Y, Chen C, Chong PL, Liu-Chen LY. Localization of the kappa opioid receptor in lipid rafts. The Journal of Pharmacology and Experimental Therapeutics. 317: 1295-306. PMID 16505160 DOI: 10.1124/jpet.105.099507  0.96
2006 Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S. The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. Annual Review of Physiology. 68: 491-505. PMID 16460281 DOI: 10.1146/annurev.physiol.68.040104.131050  0.96
2006 Chen C, Li JG, Chen Y, Huang P, Wang Y, Liu-Chen LY. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. The Journal of Biological Chemistry. 281: 7983-93. PMID 16431922 DOI: 10.1074/jbc.M509805200  0.96
2005 Xu W, Campillo M, Pardo L, Kim de Riel J, Liu-Chen LY. The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions. Biochemistry. 44: 16014-25. PMID 16331961 DOI: 10.1021/bi050938a  0.96
2005 Tanaka S, Fan LW, Tien LT, Park Y, Liu-Chen LY, Rockhold RW, Ho IK. Butorphanol dependence increases hippocampal kappa-opioid receptor gene expression. Journal of Neuroscience Research. 82: 255-63. PMID 16130146 DOI: 10.1002/jnr.20620  0.96
2005 Lee DY, Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA, Cohen B. New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors. Bioorganic & Medicinal Chemistry. 13: 5635-9. PMID 16084728 DOI: 10.1016/j.bmc.2005.05.054  0.96
2005 Lee DY, He M, Kondaveti L, Liu-Chen LY, Ma Z, Wang Y, Chen Y, Li JG, Beguin C, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues. Bioorganic & Medicinal Chemistry Letters. 15: 4169-73. PMID 16051487 DOI: 10.1016/j.bmcl.2005.06.092  0.96
2005 Lee DY, Karnati VV, He M, Liu-Chen LY, Kondaveti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues. Bioorganic & Medicinal Chemistry Letters. 15: 3744-7. PMID 15993589 DOI: 10.1016/j.bmcl.2005.05.048  0.96
2005 Béguin C, Richards MR, Wang Y, Chen Y, Liu-Chen LY, Ma Z, Lee DY, Carlezon WA, Cohen BM. Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorganic & Medicinal Chemistry Letters. 15: 2761-5. PMID 15869877 DOI: 10.1016/j.bmcl.2005.03.113  0.96
2005 Wang Y, Tang K, Inan S, Siebert D, Holzgrabe U, Lee DY, Huang P, Li JG, Cowan A, Liu-Chen LY. Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo. The Journal of Pharmacology and Experimental Therapeutics. 312: 220-30. PMID 15383632 DOI: 10.1124/jpet.104.073668  0.96
2004 Liu-Chen LY. Agonist-induced regulation and trafficking of kappa opioid receptors. Life Sciences. 75: 511-36. PMID 15158363 DOI: 10.1016/j.lfs.2003.10.041  0.96
2004 Huang P, Steplock D, Weinman EJ, Hall RA, Ding Z, Li J, Wang Y, Liu-Chen LY. kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. The Journal of Biological Chemistry. 279: 25002-9. PMID 15070904 DOI: 10.1074/jbc.M313366200  0.96
2004 Chen C, Li J, Bot G, Szabo I, Rogers TJ, Liu-Chen LY. Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor. European Journal of Pharmacology. 483: 175-86. PMID 14729105 DOI: 10.1016/j.ejphar.2003.10.033  0.96
2003 Wang Y, Li JG, Huang P, Xu W, Liu-Chen LY. Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation. The Journal of Pharmacology and Experimental Therapeutics. 307: 1127-34. PMID 14557376 DOI: 10.1124/jpet.103.055814  0.96
2003 Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. Journal of Leukocyte Biology. 74: 1074-82. PMID 12972507 DOI: 10.1189/jlb.0203067  0.96
2003 Filipovska J, Gomes I, Xu W, Chen C, Liu-Chen LY, Devi LA. Recombinant opioid receptors. Structure-function relationship. Methods in Molecular Medicine. 84: 185-203. PMID 12703324 DOI: 10.1385/1-59259-379-8:185  0.96
2003 Li JG, Zhang F, Jin XL, Liu-Chen LY. Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation. The Journal of Pharmacology and Experimental Therapeutics. 305: 531-40. PMID 12606694 DOI: 10.1124/jpet.102.045559  0.96
2002 Huang P, Visiers I, Weinstein H, Liu-Chen LY. The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant. Biochemistry. 41: 11972-80. PMID 12356297 DOI: 10.1021/bi026067b  0.96
2002 Zhang F, Li J, Li JG, Liu-Chen LY. (-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation. The Journal of Pharmacology and Experimental Therapeutics. 302: 1184-92. PMID 12183679 DOI: 10.1124/jpet.302.3.1184  0.96
2002 Li JG, Chen C, Liu-Chen LY. Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. The Journal of Biological Chemistry. 277: 27545-52. PMID 12004055 DOI: 10.1074/jbc.M200058200  0.96
2002 Li J, Li JG, Chen C, Zhang F, Liu-Chen LY. Molecular basis of differences in (-)(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneacetamide-induced desensitization and phosphorylation between human and rat kappa-opioid receptors expressed in Chinese hamster ovary cells. Molecular Pharmacology. 61: 73-84. PMID 11752208 DOI: 10.1124/mol.61.1.73  0.96
2001 Huang P, Li J, Chen C, Visiers I, Weinstein H, Liu-Chen LY. Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry. 40: 13501-9. PMID 11695897 DOI: 10.1021/bi010917q  0.96
2001 Li J, Chen C, Huang P, Liu-Chen LY. Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation. Molecular Pharmacology. 60: 1064-75. PMID 11641435  0.96
2001 Li J, Huang P, Chen C, de Riel JK, Weinstein H, Liu-Chen LY. Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry. 40: 12039-50. PMID 11580279 DOI: 10.1021/bi0100945  0.96
2001 Xu W, Li J, Chen C, Huang P, Weinstein H, Javitch JA, Shi L, de Riel JK, Liu-Chen LY. Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. Biochemistry. 40: 8018-29. PMID 11434771 DOI: 10.1021/bi002490d  0.96
2001 Chen X, McClatchy DB, Geller EB, Liu-Chen L, Tallarida RJ, Adler MW. Possible mechanism of hypothermia induced by intracerebroventricular injection of orphanin FQ/nociceptin. Brain Research. 904: 252-8. PMID 11406123 DOI: 10.1016/S0006-8993(01)02467-2  0.96
2001 Huang P, Kehner GB, Cowan A, Liu-Chen LY. Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. The Journal of Pharmacology and Experimental Therapeutics. 297: 688-95. PMID 11303059  0.96
2000 Xu W, Chen C, Huang P, Li J, de Riel JK, Javitch JA, Liu-Chen LY. The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors. Biochemistry. 39: 13904-15. PMID 11076532 DOI: 10.1021/bi001099p  0.96
2000 Li JG, Benovic JL, Liu-Chen LY. Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation. Molecular Pharmacology. 58: 795-801. PMID 10999950  0.96
2000 McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR. The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore. Molecular Pharmacology. 58: 669-76. PMID 10999935  0.96
2000 Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL. Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 275: 10443-52. PMID 10744734 DOI: 10.1074/jbc.275.14.10443  0.96
2000 Aicher SA, Sharma S, Cheng PY, Liu-Chen LY, Pickel VM. Dual ultrastructural localization of mu-opiate receptors and substance p in the dorsal horn. Synapse (New York, N.Y.). 36: 12-20. PMID 10700022 DOI: 10.1002/(SICI)1098-2396(200004)36:1<12::AID-SYN2>3.0.CO;2-E  0.96
1999 Zhang D, Li JG, Chen C, Liu-Chen LY. Nucleoside diphosphate kinase associated with membranes modulates mu-opioid receptor-mediated [35S]GTPgammaS binding and agonist binding to mu-opioid receptor. European Journal of Pharmacology. 377: 223-31. PMID 10456435 DOI: 10.1016/S0014-2999(99)00387-8  0.96
1999 Li JG, Chen C, Yin J, Rice K, Zhang Y, Matecka D, de Riel JK, DesJarlais RL, Liu-Chen LY. ASP147 in the third transmembrane helix of the rat mu opioid receptor forms ion-pairing with morphine and naltrexone. Life Sciences. 65: 175-85. PMID 10416823  0.96
1999 Xu W, Ozdener F, Li JG, Chen C, de Riel JK, Weinstein H, Liu-Chen LY. Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor. Febs Letters. 447: 318-24. PMID 10214970 DOI: 10.1016/S0014-5793(99)00316-6  0.96
1999 Li JG, Luo LY, Krupnick JG, Benovic JL, Liu-Chen LY. U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 274: 12087-94. PMID 10207034 DOI: 10.1074/jbc.274.17.12087  0.96
1998 Chen C, Shahabi V, Xu W, Liu-Chen LY. Palmitoylation of the rat mu opioid receptor. Febs Letters. 441: 148-52. PMID 9877183 DOI: 10.1016/S0014-5793(98)01547-6  0.96
1998 Alicea C, Belkowski SM, Sliker JK, Zhu J, Liu-Chen LY, Eisenstein TK, Adler MW, Rogers TJ. Characterization of kappa-opioid receptor transcripts expressed by T cells and macrophages. Journal of Neuroimmunology. 91: 55-62. PMID 9846819 DOI: 10.1016/S0165-5728(98)00151-9  0.96
1998 Li JG, Raffa RB, Cheung P, Tzeng TB, Liu-Chen LY. Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor. European Journal of Pharmacology. 354: 227-37. PMID 9754924 DOI: 10.1016/S0014-2999(98)00444-0  0.96
1998 Zhu J, Luo LY, Mao GF, Ashby B, Liu-Chen LY. Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in Chinese hamster ovary cells. The Journal of Pharmacology and Experimental Therapeutics. 285: 28-36. PMID 9535991  0.96
1998 Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(SICI)1098-2396(199802)28:2<117::AID-SYN2>3.0.CO;2-E  0.96
1997 Cheng PY, Liu-Chen LY, Pickel VM. Dual ultrastructural immunocytochemical labeling of mu and delta opioid receptors in the superficial layers of the rat cervical spinal cord. Brain Research. 778: 367-80. PMID 9459554 DOI: 10.1016/S0006-8993(97)00891-3  0.96
1997 Chen C, Yin J, Li JG, Xue JC, Weerawarna SA, Nelson WL, Liu-Chen LY. Irreversible binding of N-methyl-N-[(1S)-1-(4-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl-3,4 -dichlorophenylacetamide to the cloned rat kappa opioid receptor. Life Sciences. 61: 787-94. PMID 9275008 DOI: 10.1016/S0024-3205(97)00560-2  0.96
1997 Xin L, Geller EB, Liu-Chen LY, Chen C, Adler MW. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. The Journal of Pharmacology and Experimental Therapeutics. 282: 1055-63. PMID 9262375  0.96
1997 Zhu J, Luo LY, Li JG, Chen C, Liu-Chen LY. Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. The Journal of Pharmacology and Experimental Therapeutics. 282: 676-84. PMID 9262330  0.96
1996 Chen XH, Geller EB, DeRiel JK, Liu-Chen LY, Adler MW. Antisense confirmation of mu- and kappa-opioid receptor mediation of morphine's effects on body temperature in rats. Drug and Alcohol Dependence. 43: 119-24. PMID 9023067 DOI: 10.1016/S0376-8716(96)01295-1  0.96
1996 Chen XH, Liu-Chen LY, Tallarida RJ, Geller EB, de Riel JK, Adler MW. Use of a mu-antisense oligodeoxynucleotide as a mu opioid receptor noncompetitive antagonist in vivo. Neurochemical Research. 21: 1363-8. PMID 8947926  0.96
1996 Cheng PY, Liu-Chen LY, Chen C, Pickel VM. Immunolabeling of Mu opioid receptors in the rat nucleus of the solitary tract: extrasynaptic plasmalemmal localization and association with Leu5-enkephalin. The Journal of Comparative Neurology. 371: 522-36. PMID 8841907 DOI: 10.1002/(SICI)1096-9861(19960805)371:4<522::AID-CNE3>3.0.CO;2-6  0.96
1996 Chen C, Yin J, Riel JK, DesJarlais RL, Raveglia LF, Zhu J, Liu-Chen LY. Determination of the amino acid residue involved in [3H]beta-funaltrexamine covalent binding in the cloned rat mu-opioid receptor. The Journal of Biological Chemistry. 271: 21422-9. PMID 8702924 DOI: 10.1074/jbc.271.35.21422  0.96
1996 Zhu J, Xue JC, Law PY, Claude PA, Luo LY, Yin J, Chen C, Liu-Chen LY. The region in the mu opioid receptor conferring selectivity for sufentanil over the delta receptor is different from that over the kappa receptor. Febs Letters. 384: 198-202. PMID 8612823 DOI: 10.1016/0014-5793(96)00312-2  0.96
1996 Zhu J, Yin J, Law PY, Claude PA, Rice KC, Evans CJ, Chen C, Yu L, Liu-Chen LY. Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain. The Journal of Biological Chemistry. 271: 1430-4. PMID 8576134 DOI: 10.1074/jbc.271.3.1430  0.96
1995 Chen XH, Geller EB, de Riel JK, Liu-Chen LY, Adler MW. Antisense oligodeoxynucleotides against mu- or kappa-opioid receptors block agonist-induced body temperature changes in rats. Brain Research. 688: 237-41. PMID 8542317 DOI: 10.1016/0006-8993(95)00564-7  0.96
1995 Zhu J, Chen C, Xue JC, Kunapuli S, DeRiel JK, Liu-Chen LY. Cloning of a human kappa opioid receptor from the brain. Life Sciences. 56: PL201-7. PMID 7869844 DOI: 10.1016/0024-3205(94)00507-O  0.96
1995 Liu-Chen LY, Yang HH, Li S, Adams JU. Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition. The Journal of Pharmacology and Experimental Therapeutics. 273: 1047-56. PMID 7791074  0.96
1995 Chen XH, Adams JU, Geller EB, DeRiel JK, Adler MW, Liu-Chen LY. An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats. European Journal of Pharmacology. 275: 105-8. PMID 7774656 DOI: 10.1016/0014-2999(95)00012-A  0.96
1995 Xue JC, Chen C, Zhu J, Kunapuli SP, de Riel JK, Yu L, Liu-Chen LY. The third extracellular loop of the mu opioid receptor is important for agonist selectivity. The Journal of Biological Chemistry. 270: 12977-9. PMID 7768887  0.96
1995 Chen C, Xue JC, Zhu J, Chen YW, Kunapuli S, Kim de Riel J, Yu L, Liu-Chen LY. Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor. The Journal of Biological Chemistry. 270: 17866-70. PMID 7629089  0.48
1995 Prather PL, McGinn TM, Claude PA, Liu-Chen LY, Loh HH, Law PY. Properties of a kappa-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors. Brain Research. Molecular Brain Research. 29: 336-46. PMID 7609621 DOI: 10.1016/0169-328X(94)00264-F  0.96
1995 Belkowski SM, Zhu J, Liu-Chen LY, Eisenstein TK, Adler MW, Rogers TJ. Detection of kappa-opioid receptor mRNA in immature T cells. Advances in Experimental Medicine and Biology. 373: 11-6. PMID 7545346  0.96
1995 Belkowski SM, Zhu J, Liu-Chen LY, Eisenstein TK, Adler MW, Rogers TJ. Sequence of kappa-opioid receptor cDNA in the R1.1 thymoma cell line. Journal of Neuroimmunology. 62: 113-7. PMID 7499487 DOI: 10.1016/0165-5728(95)00116-J  0.96
1994 Kunapuli SP, Fen Mao G, Bastepe M, Liu-Chen LY, Li S, Cheung PP, DeRiel JK, Ashby B. Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells. The Biochemical Journal. 298: 263-7. PMID 8135729  0.96
1994 Xue JC, Chen C, Zhu J, Kunapuli S, DeRiel JK, Yu L, Liu-Chen LY. Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor. The Journal of Biological Chemistry. 269: 30195-9. PMID 7982926  0.96
1994 Adams JU, Chen X, DeRiel JK, Adler MW, Liu-Chen LY. Intracerebroventricular treatment with an antisense oligodeoxynucleotide to kappa-opioid receptors inhibited kappa-agonist-induced analgesia in rats. Brain Research. 667: 129-32. PMID 7895075 DOI: 10.1016/0006-8993(94)91723-X  0.96
1994 Xue J, Chen C, Kunapuli S, DeRiel K, Yu L, Liu-Chen L. Identification of binding domains on κ opioid receptors: A chimeric μ/κ opioid receptor study Regulatory Peptides. 54: 335-336. DOI: 10.1016/0167-0115(94)90525-8  0.96
1994 Xin L, Geller E, Liu-Chen LY, Adler M. Involvement of β-endorphin (β-E) in supraspinal substance P (SP) antinociception Regulatory Peptides. 54: 329-330. DOI: 10.1016/0167-0115(94)90522-3  0.96
1994 Chen C, Xue J, Kunapuli S, Chen YW, DeRiel K, Yu L, Liu-Chen LY. Determination of the region in the μ opioid receptor involved in covalent binding of β-FNA Regulatory Peptides. 54: 53-54. DOI: 10.1016/0167-0115(94)90385-9  0.96
1994 Adams J, Chen X, DeRiel J, Adler M, Liu-Chen LY. In vivo treatment with antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats Regulatory Peptides. 54: 1-2. DOI: 10.1016/0167-0115(94)90359-X  0.96
1994 Liu-Chen LY, Yang HH, Li S, Adams J. Intracerebroventricular administration of ß-funaltrexamine (ß-FNA) reduces μ opioid receptor binding Regulatory Peptides. 53: S77-S78. DOI: 10.1016/0167-0115(94)90249-6  0.96
1994 Li S, Zhu J, Chen C, Chen YW, Smyth RJ, Sakolsky DJ, Sheng S, Cao W, deRiel JK, Ashby B, Liu-Chen LY. Cloning and expression of a rat opioid receptor with κ characteristics Regulatory Peptides. 53: S11-S12. DOI: 10.1016/0167-0115(94)90216-X  0.96
1993 Bell J, Adler MW, Greenstein JI, Liu-Chen LY. Identification and characterization of [125I]arginine vasopressin binding sites on human peripheral blood mononuclear cells. Life Sciences. 52: 95-105. PMID 8417282 DOI: 10.1016/0024-3205(93)90292-B  0.96
1993 Li S, Zhu J, Chen C, Chen YW, Deriel JK, Ashby B, Liu-Chen LY. Molecular cloning and expression of a rat kappa opioid receptor. The Biochemical Journal. 295: 629-33. PMID 8240268  0.96
1993 Liu-Chen LY, Chen C, Phillips CA. Beta-[3H]funaltrexamine-labeled mu-opioid receptors: species variations in molecular mass and glycosylation by complex-type, N-linked oligosaccharides. Molecular Pharmacology. 44: 749-56. PMID 8232225  0.96
1991 Liu-Chen LY, Li SX, Wheeler-Aceto H, Cowan A. Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception. European Journal of Pharmacology. 203: 195-202. PMID 1666046 DOI: 10.1016/0014-2999(91)90715-3  0.96
1991 Liu-Chen LY, Li SX, Lewis ME. Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution. Brain Research. 544: 235-42. PMID 1645609 DOI: 10.1016/0006-8993(91)90059-5  0.96
1990 Liu-Chen LY, Li SX, Rohrbach KW, Lewis ME. [3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study. Progress in Clinical and Biological Research. 328: 61-4. PMID 2154819  0.96
1990 Liu-Chen LY, Li S, Holowecky O, Tallarida RJ. Kinetic studies on binding of [3H] beta-funaltrexamine ([3H] beta-FNA) to mu opioid receptors. Progress in Clinical and Biological Research. 328: 57-60. PMID 2154818  0.96
1990 Liu-Chen LY, Li SX, Tallarida RJ. Studies on kinetics of [3H]beta-funaltrexamine binding to mu opioid receptor. Molecular Pharmacology. 37: 243-50. PMID 2154672  0.96
1990 Tiseo PJ, Adler MW, Liu-Chen LY. Differential release of substance P and somatostatin in the rat spinal cord in response to noxious cold and heat; effect of dynorphin A(1-17). The Journal of Pharmacology and Experimental Therapeutics. 252: 539-45. PMID 1690293  0.96
1990 Liu-Chen LY, Li S, Wheeler-Aceto H, Cowan A. Effects of intracerebroventricular β-funaltrexamine treatment on opioid receptors: Binding and behavioral studies New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 67-68.  0.96
1989 Tiseo PJ, Adler MW, Liu-Chen LY. Differential release of substance P and somatostatin in the rat spinal cord in response to noxious cold and heat: effect of dynorphin A(1-17). Nida Research Monograph. 95: 297. PMID 2484266  0.96
1987 Liu-Chen LY, Phillips CA. Covalent labeling of mu opioid binding site by [3H]beta-funaltrexamine. Molecular Pharmacology. 32: 321-9. PMID 2823089  0.96
1987 Saito K, Liu-Chen LY, Moskowitz MA. Substance P-like immunoreactivity in rat forebrain leptomeninges and cerebral vessels originates from the trigeminal but not sympathetic ganglia. Brain Research. 403: 66-71. PMID 2435368 DOI: 10.1016/0006-8993(87)90123-5  0.96
1986 Tam SW, Liu-Chen LY. Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes. The Journal of Pharmacology and Experimental Therapeutics. 239: 351-7. PMID 3021954  0.96
1986 Liu-Chen LY, Liszczak TM, King JC, Moskowitz MA. Immunoelectron microscopic study of substance P-containing fibers in feline cerebral arteries. Brain Research. 369: 12-20. PMID 2421844 DOI: 10.1016/0006-8993(86)90508-1  0.96
1985 Liu-Chen LY, Norregaard TV, Moskowitz MA. Some cholecystokinin-8 immunoreactive fibers in large pial arteries originate from trigeminal ganglion. Brain Research. 359: 166-76. PMID 3907751 DOI: 10.1016/0006-8993(85)91425-8  0.96
1985 Tam SW, Nickolson VJ, Liu-Chen LY. [3H]beta-funaltrexamine binds covalently to brain opioid receptors. European Journal of Pharmacology. 119: 259-60. PMID 3004996 DOI: 10.1016/0014-2999(85)90307-3  0.96
1984 Liu-Chen LY, Gillespie SA, Norregaard TV, Moskowitz MA. Co-localization of retrogradely transported wheat germ agglutinin and the putative neurotransmitter substance P within trigeminal ganglion cells projecting to cat middle cerebral artery. The Journal of Comparative Neurology. 225: 187-92. PMID 6202727 DOI: 10.1002/cne.902250204  0.96
1984 Liu-Chen LY, Gillespie SA, Norregaard TV. Cholecystokinin-8 (CCK8) immunoreactivity in cerebral arteries and pia arachnoid and the effect of unilateral trigeminal ganglionectomy Federation Proceedings. 43: no. 113.  0.96
1983 Moskowitz MA, Brody M, Liu-Chen LY. In vitro release of immunoreactive substance P from putative afferent nerve endings in bovine pia arachnoid. Neuroscience. 9: 809-14. PMID 6194478 DOI: 10.1016/0306-4522(83)90269-5  0.96
1983 Liu-Chen LY, Han DH, Moskowitz MA. Pia arachnoid contains substance P originating from trigeminal neurons. Neuroscience. 9: 803-8. PMID 6194477 DOI: 10.1016/0306-4522(83)90268-3  0.96
1983 Liu-Chen LY, Mayberg MR, Moskowitz MA. Immunohistochemical evidence for a substance P-containing trigeminovascular pathway to pial arteries in cats. Brain Research. 268: 162-6. PMID 6190538 DOI: 10.1016/0006-8993(83)90402-X  0.96
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