Tara L. Spires-Jones - Publications

University of Edinburgh, Edinburgh, Scotland, United Kingdom 
dendritic spine plasticity, Alzheimer's disease

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Tzioras M, Daniels MJD, Davies C, Baxter P, King D, McKay S, Varga B, Popovic K, Hernandez M, Stevenson AJ, Barrington J, Drinkwater E, Borella J, Holloway RK, Tulloch J, ... ... Spires-Jones TL, et al. Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8. Cell Reports. Medicine. 101175. PMID 37652017 DOI: 10.1016/j.xcrm.2023.101175  0.464
2023 Davies C, Tulloch J, Yip E, Currie L, Colom-Cadena M, Wegmann S, Hyman BT, Wilkins L, Hooley M, Tzioras M, Spires-Jones TL. Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model. Brain and Neuroscience Advances. 7: 23982128231191046. PMID 37600228 DOI: 10.1177/23982128231191046  0.816
2023 Mouofo EN, Spires-Jones TL. Reeling from news that reelin defends the brain against Alzheimer's. Cell Reports. Medicine. 4: 101111. PMID 37467729 DOI: 10.1016/j.xcrm.2023.101111  0.32
2023 Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sánchez-Aced É, Chang YY, Holt K, McGeachan RI, Rose J, Tulloch J, Wilkins L, Smith C, ... ... Spires-Jones TL, et al. Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. Neuron. PMID 37192625 DOI: 10.1016/j.neuron.2023.04.020  0.552
2023 Saunders TS, Pozzolo FE, Heslegrave A, King D, McGeachan RI, Spires-Jones MP, Harris SE, Ritchie C, Muniz-Terrera G, Deary IJ, Cox SR, Zetterberg H, Spires-Jones TL. Predictive blood biomarkers and brain changes associated with age-related cognitive decline. Brain Communications. 5: fcad113. PMID 37180996 DOI: 10.1093/braincomms/fcad113  0.444
2023 Williams E, Mutlu-Smith M, Alex A, Chin XW, Spires-Jones T, Wang SH. Mid-Adulthood Cognitive Training Improves Performance in a Spatial Task but Does Not Ameliorate Hippocampal Pathology in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 37066912 DOI: 10.3233/JAD-221185  0.321
2023 Saunders T, Gunn C, Blennow K, Kvartsberg H, Zetterberg H, Shenkin SD, Cox SR, Deary IJ, Smith C, King D, Spires-Jones T. Neurogranin in Alzheimer's disease and ageing: A human post-mortem study. Neurobiology of Disease. 177: 105991. PMID 36623608 DOI: 10.1016/j.nbd.2023.105991  0.396
2022 Vacher MC, Durrant CS, Rose J, Hall AJ, Spires-Jones TL, Gunn-Moore F, Dagleish MP. Alzheimer's disease-like neuropathology in three species of oceanic dolphin. The European Journal of Neuroscience. PMID 36514861 DOI: 10.1111/ejn.15900  0.484
2022 Tzioras M, McGeachan RI, Durrant CS, Spires-Jones TL. Synaptic degeneration in Alzheimer disease. Nature Reviews. Neurology. 19: 19-38. PMID 36513730 DOI: 10.1038/s41582-022-00749-z  0.542
2022 Porsteinsson AP, Rangaraju S, Spires-Jones TL, O'Banion MK. Alzheimer's Disease and Related Dementias: From Risk Factors to Disease Pathogenesis. The European Journal of Neuroscience. PMID 36324230 DOI: 10.1111/ejn.15857  0.3
2022 Rupawala H, Shah K, Davies C, Rose J, Colom-Cadena M, Peng X, Granat L, Aljuhani M, Mizuno K, Troakes C, Perez-Nievas BG, Morgan A, So PW, Hortobagyi T, Spires-Jones TL, et al. Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease. Brain Communications. 4: fcac192. PMID 35928052 DOI: 10.1093/braincomms/fcac192  0.435
2022 Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, Burr K, Davies C, Colom-Cadena M, Chandran S, Large CH, Rowan MJM, Gunthorpe MJ, Spires-Jones TL. Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease. Brain and Neuroscience Advances. 6: 23982128221086464. PMID 35359460 DOI: 10.1177/23982128221086464  0.538
2022 King D, Spires-Jones TL. Tau talk - synaptic and mitochondrial proteins interact with Tau in human neurons. Trends in Neurosciences. 45: 339-341. PMID 35232606 DOI: 10.1016/j.tins.2022.02.004  0.397
2022 Jiwaji Z, Tiwari SS, Avilés-Reyes RX, Hooley M, Hampton D, Torvell M, Johnson DA, McQueen J, Baxter P, Sabari-Sankar K, Qiu J, He X, Fowler J, Febery J, Gregory J, ... ... Spires-Jones TL, et al. Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology. Nature Communications. 13: 135. PMID 35013236 DOI: 10.1038/s41467-021-27702-w  0.638
2021 Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, ... ... Spires-Jones T, et al. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathology (Zurich, Switzerland). e13035. PMID 34779076 DOI: 10.1111/bpa.13035  0.807
2021 Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, ... Spires-Jones TL, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Molecular Neurobiology. PMID 34757590 DOI: 10.1007/s12035-021-02557-w  0.795
2021 Kurucu H, Colom-Cadena M, Davies C, Wilkins L, King D, Rose J, Tzioras M, Tulloch JH, Smith C, Spires-Jones TL. Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer's disease. European Journal of Neurology. PMID 34331352 DOI: 10.1111/ene.15043  0.487
2021 Lin Z, Kim E, Ahmed M, Han G, Simmons C, Redhead Y, Bartlett J, Pena Altamira LE, Callaghan I, White MA, Singh N, Sawiak S, Spires-Jones T, Vernon AC, Coleman MP, et al. MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia. Brain Communications. 3: fcab114. PMID 34136812 DOI: 10.1093/braincomms/fcab114  0.331
2021 Izzo NJ, Yuede CM, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Waybright L, Look G, Rishton G, Safferstein H, Hamby ME, Williams C, Sadlek K, Edwards HM, Davis CS, ... ... Spires-Jones TL, et al. Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33559354 DOI: 10.1002/alz.12302  0.386
2021 Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P. Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation. Neuron. PMID 33472038 DOI: 10.1016/j.neuron.2020.12.016  0.415
2021 Zoupi L, Booker SA, Eigel D, Werner C, Kind PC, Spires-Jones TL, Newland B, Williams AC. Selective vulnerability of inhibitory networks in multiple sclerosis. Acta Neuropathologica. PMID 33449171 DOI: 10.1007/s00401-020-02258-z  0.421
2020 Tulloch J, Netsyk O, Pickett EK, Herrmann AG, Jain P, Stevenson AJ, Oren I, Hardt O, Spires-Jones TL. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European Journal of Neuroscience. PMID 33169893 DOI: 10.1111/Ejn.14918  0.857
2020 Saied I, Arslan T, Chandran S, Smith C, Spires-Jones T, Pal S. Non-Invasive RF Technique for Detecting Different Stages of Alzheimer's Disease and Imaging Beta-Amyloid Plaques and Tau Tangles in the Brain. Ieee Transactions On Medical Imaging. PMID 32746147 DOI: 10.1109/Tmi.2020.3011359  0.462
2020 Kent SA, Spires-Jones TL, Durrant CS. The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. Acta Neuropathologica. PMID 32728795 DOI: 10.1007/S00401-020-02196-W  0.556
2020 Colom-Cadena M, Spires-Jones T, Zetterberg H, Blennow K, Caggiano A, DeKosky ST, Fillit H, Harrison JE, Schneider LS, Scheltens P, de Haan W, Grundman M, van Dyck CH, Izzo NJ, Catalano SM, et al. The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease. Alzheimer's Research & Therapy. 12: 21. PMID 32122400 DOI: 10.1186/S13195-020-00588-4  0.508
2020 Stevens B, Blurton-Jones M, Spires-Jones TL. Decision letter: Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models Elife. DOI: 10.7554/Elife.54083.Sa1  0.469
2019 Hesse R, Hurtado ML, Jackson RJ, Eaton SL, Herrmann AG, Colom-Cadena M, Tzioras M, King D, Rose J, Tulloch J, McKenzie CA, Smith C, Henstridge CM, Lamont D, Wishart TM, ... Spires-Jones TL, et al. Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype. Acta Neuropathologica Communications. 7: 214. PMID 31862015 DOI: 10.1186/S40478-019-0847-7  0.802
2019 Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, et al. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathologica. PMID 31853635 DOI: 10.1007/S00401-019-02114-9  0.517
2019 Jackson RJ, Rose J, Tulloch J, Henstridge C, Smith C, Spires-Jones TL. Clusterin accumulates in synapses in Alzheimer's disease and is increased in apolipoprotein E4 carriers. Brain Communications. 1: fcz003. PMID 31853523 DOI: 10.1093/braincomms/fcz003  0.796
2019 Pickett EK, Herrmann AG, McQueen J, Abt K, Dando O, Tulloch J, Jain P, Dunnett S, Sohrabi S, Fjeldstad MP, Calkin W, Murison L, Jackson RJ, Tzioras M, Stevenson A, ... ... Spires-Jones TL, et al. Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease. Cell Reports. 29: 3592-3604.e5. PMID 31825838 DOI: 10.1016/J.Celrep.2019.11.044  0.86
2019 Mauricio R, Benn C, Davis J, Dawson G, Dawson LA, Evans A, Fox N, Gallacher J, Hutton M, Isaac J, Jones DNC, Jones L, Lalli G, Libri V, Lovestone S, ... ... Spires-Jones T, et al. Tackling gaps in developing life-changing treatments for dementia. Alzheimer's & Dementia (New York, N. Y.). 5: 241-253. PMID 31297438 DOI: 10.1016/J.Trci.2019.05.001  0.333
2019 Querol-Vilaseca M, Colom-Cadena M, Pegueroles J, Nuñez-Llaves R, Luque-Cabecerans J, Muñoz-Llahuna L, Andilla J, Belbin O, Spires-Jones TL, Gelpi E, Clarimon J, Loza-Alvarez P, Fortea J, Lleó A. Nanoscale structure of amyloid-β plaques in Alzheimer's disease. Scientific Reports. 9: 5181. PMID 30914681 DOI: 10.1038/S41598-019-41443-3  0.544
2019 Noble W, Spires-Jones TL. Sleep well to slow Alzheimer's progression? Science (New York, N.Y.). 363: 813-814. PMID 30792288 DOI: 10.1126/Science.Aaw5583  0.306
2019 Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, Kuchibhotla KV, Betensky RA, Spires-Jones T, Hyman BT. Opposing Roles of apolipoprotein E in aging and neurodegeneration. Life Science Alliance. 2. PMID 30760557 DOI: 10.26508/lsa.201900325  0.581
2019 Henstridge CM, Hyman BT, Spires-Jones TL. Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nature Reviews. Neuroscience. 20: 94-108. PMID 30643230 DOI: 10.1038/S41583-018-0113-1  0.786
2019 Lleó A, Núñez-Llaves R, Alcolea D, Chiva C, Balateu-Paños D, Colom-Cadena M, Gomez-Giro G, Muñoz L, Querol-Vilaseca M, Pegueroles J, Rami L, Lladó A, Molinuevo JL, Tainta M, Clarimón J, ... Spires-Jones T, et al. Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid. Molecular & Cellular Proteomics : McP. 18: 546-560. PMID 30606734 DOI: 10.1074/Mcp.Ra118.001290  0.466
2018 Davies C, Spires-Jones TL. Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies. Neuron. 100: 1267-1269. PMID 30571935 DOI: 10.1016/J.Neuron.2018.12.003  0.362
2018 Tzioras M, Davies C, Newman A, Jackson R, Spires-Jones T. APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease. Neuropathology and Applied Neurobiology. PMID 30394574 DOI: 10.1111/Nan.12529  0.582
2018 Pickett EK, Rose J, McCrory C, McKenzie CA, King D, Smith C, Gillingwater TH, Henstridge CM, Spires-Jones TL. Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease. Acta Neuropathologica. PMID 30191401 DOI: 10.1007/S00401-018-1903-2  0.808
2018 Spires-Jones TL, Ritchie CW. A brain boost to fight Alzheimer's disease. Science (New York, N.Y.). 361: 975-976. PMID 30190391 DOI: 10.1126/Science.Aau8060  0.464
2018 Henstridge CM, Spires-Jones TL. Modeling Alzheimer's disease brains in vitro. Nature Neuroscience. PMID 29950667 DOI: 10.1038/S41593-018-0177-2  0.787
2018 Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Föhr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, et al. sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Cahomeostasis and CREB1-signaling. Experimental Neurology. PMID 29466703 DOI: 10.1016/J.Expneurol.2018.02.010  0.55
2018 McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. PMID 29398363 DOI: 10.1016/J.Neuron.2018.01.022  0.585
2018 Belbin O, Núñez-Llaves R, Alcolea D, Balateu D, Colom-Cadena M, Gomez-Giro G, Muñoz-Llahuna L, Querol-Vilaseca M, Pegueroles J, Rami L, Lladó A, Molinuevo JL, Tainta M, Clarimon J, Spires-Jones T, et al. P2-262: A Cerebrospinal Fluid Panel Of Synaptic Proteins Across The Entire Alzheimer'S Disease Continuum Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.951  0.462
2017 Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, ... ... Spires-Jones TL, et al. Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis. Acta Neuropathologica. PMID 29273900 DOI: 10.1007/S00401-017-1797-4  0.75
2017 Infante-Garcia C, Ramos-Rodriguez JJ, Hierro-Bujalance C, Ortegon E, Pickett E, Jackson R, Hernandez-Pacho F, Spires-Jones T, Garcia-Alloza M. Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer's Disease and Type 2 Diabetes. Molecular Neurobiology. PMID 29224179 DOI: 10.1007/S12035-017-0825-7  0.499
2017 Colom-Cadena M, Pegueroles J, Herrmann AG, Henstridge CM, Muñoz L, Querol-Vilaseca M, Martín-Paniello CS, Luque-Cabecerans J, Clarimon J, Belbin O, Núñez-Llaves R, Blesa R, Smith C, McKenzie CA, Frosch MP, ... ... Spires-Jones TL, et al. Synaptic phosphorylated α-synuclein in dementia with Lewy bodies. Brain : a Journal of Neurology. 140: 3204-3214. PMID 29177427 DOI: 10.1093/Brain/Awx275  0.818
2017 Xu C, Yu L, Hou J, Jackson RJ, Wang H, Huang C, Liu T, Wang Q, Zou X, Morris RG, Spires-Jones TL, Yang Z, Yin Z, Xu Y, Chen G. Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development. Frontiers in Cellular Neuroscience. 11: 330. PMID 29104535 DOI: 10.3389/Fncel.2017.00330  0.35
2017 Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse T, Spires-Jones TL, Walsh DM. Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29101243 DOI: 10.1523/Jneurosci.2009-17.2017  0.577
2017 Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. PMID 28669544 DOI: 10.1016/J.Neuron.2017.05.037  0.825
2017 Zhou L, McInnes J, Wierda K, Holt M, Herrmann AG, Jackson RJ, Wang YC, Swerts J, Beyens J, Miskiewicz K, Vilain S, Dewachter I, Moechars D, De Strooper B, Spires-Jones TL, et al. Tau association with synaptic vesicles causes presynaptic dysfunction. Nature Communications. 8: 15295. PMID 28492240 DOI: 10.1038/Ncomms15295  0.797
2017 Spires-Jones TL, Attems J, Thal DR. Interactions of pathological proteins in neurodegenerative diseases. Acta Neuropathologica. PMID 28401333 DOI: 10.1007/S00401-017-1709-7  0.525
2017 Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse (New York, N.Y.). PMID 28196395 DOI: 10.1002/Syn.21965  0.861
2017 Spires-Jones TL. INTERACTIONS OF ABETA AND TAU IN SYNAPSE LOSS Alzheimer's & Dementia. 13: P1219. DOI: 10.1016/J.Jalz.2017.07.399  0.493
2016 Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. The European Journal of Neuroscience. PMID 27748574 DOI: 10.1111/Ejn.13442  0.872
2016 Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's Disease : Jad. PMID 27258414 DOI: 10.3233/Jad-160007  0.843
2016 Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, Lechuga-Sancho AM, Bacskai BJ, Garcia-Alloza M. Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 27177549 DOI: 10.1007/S12035-016-9921-3  0.538
2016 Rudinskiy N, Fuerer C, Demurtas D, Zamorano S, De Piano C, Herrmann A, Spires-Jones TL, Oeckl P, Otto M, Frosch MP, Moniatte M, Hyman BT, Schmid AW. Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27130892 DOI: 10.1016/J.Jalz.2016.03.011  0.8
2016 Henstridge CM, Pickett E, Spires-Jones TL. Synaptic pathology: a shared mechanism in neurological disease. Ageing Research Reviews. PMID 27108053 DOI: 10.1016/J.Arr.2016.04.005  0.773
2016 Pickett E, Henstridge C, Jackson RJ, Herrmann AG, Wegmann S, Hyman BT, Carlson GA, Spires-Jones TL. EC-03-03: Tau Spreading and Toxicity Alzheimer's & Dementia. 12: P269-P269. DOI: 10.1016/J.Jalz.2016.06.2381  0.815
2015 Henstridge CM, Jackson RJ, Kim JM, Herrmann AG, Wright AK, Harris SE, Bastin ME, Starr JM, Wardlaw J, Gillingwater TH, Smith C, McKenzie CA, Cox SR, Deary IJ, Spires-Jones TL. Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse. Acta Neuropathologica Communications. 3: 83. PMID 26651483 DOI: 10.1186/s40478-015-0244-9  0.787
2015 Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, et al. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. The Embo Journal. PMID 26538322 DOI: 10.15252/Embj.201592748  0.802
2015 Henstridge CM, Jackson RJ, Kim JM, Herrmann AG, Wright AK, Harris SE, Bastin ME, Starr JM, Wardlaw J, Gillingwater TH, Smith C, McKenzie CA, Cox SR, Deary IJ, Spires-Jones TL. Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse. Acta Neuropathologica Communications. 3: 53. PMID 26335101 DOI: 10.1186/S40478-015-0232-0  0.813
2015 Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathologica Communications. 3: 14. PMID 25853174 DOI: 10.1186/S40478-015-0199-X  0.851
2015 Menkes-Caspi N, Yamin HG, Kellner V, Spires-Jones TL, Cohen D, Stern EA. Pathological tau disrupts ongoing network activity. Neuron. 85: 959-66. PMID 25704951 DOI: 10.1016/J.Neuron.2015.01.025  0.47
2015 Saidi LJ, Polydoro M, Kay KR, Sanchez L, Mandelkow EM, Hyman BT, Spires-Jones TL. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. Journal of Alzheimer's Disease : Jad. 44: 937-47. PMID 25374103 DOI: 10.3233/Jad-142094  0.818
2015 Herrmann A, Spires-Jones T. Clearing the way for tau immunotherapy in Alzheimer's disease Journal of Neurochemistry. 132: 1-4. PMID 25156069 DOI: 10.1111/Jnc.12845  0.787
2015 Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe AD, Fan Z, Nicholls SB, DeVos SL, Takeda S, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler A, Hyman BT. O2-06-01: Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice Alzheimer's & Dementia. 11: P186-P186. DOI: 10.1016/J.Jalz.2015.07.159  0.759
2014 Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, ... ... Spires-Jones TL, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899  0.531
2014 Borger E, Herrmann A, Mann DA, Spires-Jones T, Gunn-Moore F. The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia. Journal of Neuropathology and Experimental Neurology. 73: 1166-82. PMID 25383639 DOI: 10.1097/Nen.0000000000000138  0.791
2014 Tai HC, Wang BY, Serrano-Pozo A, Frosch MP, Spires-Jones TL, Hyman BT. Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease. Acta Neuropathologica Communications. 2: 146. PMID 25330988 DOI: 10.1186/S40478-014-0146-2  0.707
2014 Rudinskiy N, Hawkes JM, Wegmann S, Kuchibhotla KV, Muzikansky A, Betensky RA, Spires-Jones TL, Hyman BT. Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. Acta Neuropathologica Communications. 2: 63. PMID 24915991 DOI: 10.1186/2051-5960-2-63  0.781
2014 Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron. 82: 756-71. PMID 24853936 DOI: 10.1016/J.Neuron.2014.05.004  0.704
2014 Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neuroscience Letters. 562: 63-8. PMID 24462887 DOI: 10.1016/J.Neulet.2014.01.013  0.837
2014 Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 510-4. PMID 24368848 DOI: 10.1073/Pnas.1318807111  0.855
2014 Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathologica. 127: 257-70. PMID 24271788 DOI: 10.1007/S00401-013-1215-5  0.852
2014 Ren Y, Lin WL, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N. Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. Journal of Alzheimer's Disease : Jad. 38: 589-600. PMID 24028867 DOI: 10.3233/Jad-130986  0.821
2013 Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. Plos One. 8: e80834. PMID 24278327 DOI: 10.1371/Journal.Pone.0080834  0.833
2013 Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science Translational Medicine. 5: 212ra161. PMID 24259049 DOI: 10.1126/Scitranslmed.3007000  0.842
2013 Pooler AM, Polydoro M, Wegmann S, Nicholls SB, Spires-Jones TL, Hyman BT. Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets. Alzheimer's Research & Therapy. 5: 49. PMID 24152385 DOI: 10.1186/Alzrt214  0.873
2013 Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT. Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13300-11. PMID 23946388 DOI: 10.1523/Jneurosci.0881-13.2013  0.828
2013 Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. The Journal of Comparative Neurology. 521: 4236-48. PMID 23839581 DOI: 10.1002/Cne.23411  0.845
2013 Ramos-Rodriguez JJ, Ortiz O, Jimenez-Palomares M, Kay KR, Berrocoso E, Murillo-Carretero MI, Perdomo G, Spires-Jones T, Cozar-Castellano I, Lechuga-Sancho AM, Garcia-Alloza M. Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice Psychoneuroendocrinology. 38: 2462-2475. PMID 23790682 DOI: 10.1016/J.Psyneuen.2013.05.010  0.386
2013 Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nature Protocols. 8: 1366-80. PMID 23787894 DOI: 10.1038/Nprot.2013.078  0.796
2013 Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT. Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3239-48. PMID 23640054 DOI: 10.1096/Fj.13-229666  0.755
2013 Crimins JL, Pooler A, Polydoro M, Luebke JI, Spires-Jones TL. The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing Research Reviews. 12: 757-63. PMID 23528367 DOI: 10.1016/J.Arr.2013.03.002  0.837
2013 Ramos-Rodriguez JJ, Pacheco-Herrero M, Thyssen D, Murillo-Carretero MI, Berrocoso E, Spires-Jones TL, Bacskai BJ, Garcia-Alloza M. Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 72: 272-85. PMID 23481704 DOI: 10.1097/Nen.0B013E318288A8Dd  0.466
2013 Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. The Journal of Comparative Neurology. 521: 1334-53. PMID 23047530 DOI: 10.1002/Cne.23234  0.852
2013 Polydoro M, Hudry E, Perez-Nievas B, Arbel-Ornath M, Sanchez L, Spires-Jones T, Reumers V, Gómez-Isla T, Hyman B. P3-048: Caspase cleavage of tau is critical for oligomeric beta-amyloid-induced sub-lethal apoptotic cascade Alzheimer's & Dementia. 9: P568-P569. DOI: 10.1016/J.Jalz.2013.05.1117  0.764
2013 Kuchibhotla K, Wegmann S, Spires-Jones T, Bacskai B, Hyman B. O2-01-01: Neurofibrillary tangles remain functionally integrated in cortical networks Alzheimer's & Dementia. 9: P314-P314. DOI: 10.1016/J.Jalz.2013.04.135  0.667
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/Jneurosci.1542-12.2012  0.843
2012 Knafo S, Gouras GK, Yan XX, Spires-Jones T. Pathology of synapses and dendritic spines. Neural Plasticity. 2012: 972432. PMID 23050169 DOI: 10.1155/2012/972432  0.549
2012 Kopeikina KJ, Hyman BT, Spires-Jones TL. Soluble forms of tau are toxic in Alzheimer's disease. Translational Neuroscience. 3: 223-233. PMID 23029602 DOI: 10.2478/S13380-012-0032-Y  0.862
2012 Rudinskiy N, Hawkes JM, Betensky RA, Eguchi M, Yamaguchi S, Spires-Jones TL, Hyman BT. Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease. Nature Neuroscience. 15: 1422-9. PMID 22922786 DOI: 10.1038/Nn.3199  0.544
2012 Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American Journal of Pathology. 181: 1426-35. PMID 22867711 DOI: 10.1016/J.Ajpath.2012.06.033  0.873
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/Brain/Aws127  0.836
2012 Spires-Jones TL, Fox LM, Rozkalne A, Pitstick R, Carlson GA, Kazantsev AG. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Frontiers in Pharmacology. 3: 42. PMID 22416232 DOI: 10.3389/Fphar.2012.00042  0.549
2012 Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/Jneurosci.6439-11.2012  0.747
2012 de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 73: 685-97. PMID 22365544 DOI: 10.1016/J.Neuron.2011.11.033  0.85
2012 Spires-Jones T, Knafo S. Spines, plasticity, and cognition in Alzheimer's model mice Neural Plasticity. 2012. PMID 22203915 DOI: 10.1155/2012/319836  0.612
2012 de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease Neuron. 76: 461. DOI: 10.1016/j.neuron.2012.10.005  0.576
2011 Koffie RM, Farrar CT, Saidi LJ, William CM, Hyman BT, Spires-Jones TL. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proceedings of the National Academy of Sciences of the United States of America. 108: 18837-42. PMID 22065785 DOI: 10.1073/Pnas.1111405108  0.747
2011 Koffie RM, Hyman BT, Spires-Jones TL. Alzheimer's disease: synapses gone cold. Molecular Neurodegeneration. 6: 63. PMID 21871088 DOI: 10.1186/1750-1326-6-63  0.836
2011 Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. The American Journal of Pathology. 179: 2071-82. PMID 21854751 DOI: 10.1016/J.Ajpath.2011.07.004  0.844
2011 Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. Journal of Neuropathology and Experimental Neurology. 70: 588-95. PMID 21666499 DOI: 10.1097/Nen.0B013E318220A658  0.601
2011 Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT. Are tangles as toxic as they look? Journal of Molecular Neuroscience : Mn. 45: 438-44. PMID 21638071 DOI: 10.1007/S12031-011-9566-7  0.85
2011 Meyer-Luehmann M, Mora JR, Mielke M, Spires-Jones TL, de Calignon A, von Andrian UH, Hyman BT. T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice. Molecular Neurodegeneration. 6: 22. PMID 21388539 DOI: 10.1186/1750-1326-6-22  0.474
2011 Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/Journal.Pone.0014586  0.733
2011 Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (San Diego, Calif.). 53: 201-7. PMID 21163350 DOI: 10.1016/J.Ymeth.2010.12.009  0.645
2011 Rozkalne A, Hyman BT, Spires-Jones TL. Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice. Neurobiology of Disease. 41: 650-4. PMID 21134458 DOI: 10.1016/J.Nbd.2010.11.014  0.599
2011 Spires-Jones TL, Kay K, Matsouka R, Rozkalne A, Betensky RA, Hyman BT. Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. Neuroscience Letters. 487: 260-3. PMID 20970476 DOI: 10.1016/J.Neulet.2010.10.033  0.498
2011 Holtzman D, Hyman B, Lee V, Spires-Jones T, Koffie R, Hashimoto T, Joyner D, Hou S, Kopeikina K, Frosch M. O1-05-01: APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease Alzheimer's & Dementia. 7: S103-S104. DOI: 10.1016/J.Jalz.2011.05.256  0.833
2011 Hudry E, Hashimoto T, Scheel M, Dashkoff J, Spires-Jones T, Bacskai B, Davidson B, Hyman B. P2-465: Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 Alzheimer's & Dementia. 7: S461-S462. DOI: 10.1016/J.Jalz.2011.05.1337  0.701
2011 Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT. Erratum to: Are Tangles as Toxic as They Look? Journal of Molecular Neuroscience. 45: 742-742. DOI: 10.1007/S12031-011-9581-8  0.787
2010 de Calignon A, Spires-Jones TL, Hyman BT. [Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease]. Mã©Decine Sciences : M/S. 26: 787-9. PMID 20929661 DOI: 10.1051/Medsci/20102610787  0.558
2010 de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 464: 1201-4. PMID 20357768 DOI: 10.1038/Nature08890  0.635
2010 Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/Jneurosci.4456-09.2010  0.76
2010 Hyman BT, de Calignon A, Suarez-Calvet M, William C, Pitstick R, Carlson GA, Spires-Jones TL. PL-05-01: A transgenic model of the earliest stage of Alzheimer's disease Alzheimer's & Dementia. 6: S165-S165. DOI: 10.1016/J.Jalz.2010.05.513  0.538
2009 Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12636-40. PMID 19812338 DOI: 10.1523/Jneurosci.1948-09.2009  0.537
2009 Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. Journal of Neurochemistry. 111: 417-27. PMID 19686388 DOI: 10.1111/J.1471-4159.2009.06316.X  0.553
2009 de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. Journal of Neuropathology and Experimental Neurology. 68: 757-61. PMID 19535996 DOI: 10.1097/Nen.0B013E3181A9Fc66  0.539
2009 Rozkalne A, Spires-Jones TL, Stern EA, Hyman BT. A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model. Brain Research. 1280: 178-85. PMID 19465012 DOI: 10.1016/J.Brainres.2009.05.045  0.655
2009 Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/Pnas.0811698106  0.846
2009 Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT. Tau pathophysiology in neurodegeneration: a tangled issue. Trends in Neurosciences. 32: 150-9. PMID 19162340 DOI: 10.1016/J.Tins.2008.11.007  0.62
2009 Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiology of Disease. 33: 213-20. PMID 19028582 DOI: 10.1016/J.Nbd.2008.10.011  0.643
2008 Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 13: 014008. PMID 18315366 DOI: 10.1117/1.2837169  0.482
2008 Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 451: 720-4. PMID 18256671 DOI: 10.1038/Nature06616  0.666
2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/Jneurosci.3072-08.2008  0.513
2008 Freeman SH, Spires-Jones T, Hyman BT, Growdon JH, Frosch MP. TAR-DNA binding protein 43 in Pick disease. Journal of Neuropathology and Experimental Neurology. 67: 62-7. PMID 18091558 DOI: 10.1097/Nen.0B013E3181609361  0.556
2008 de Calignon A, Spires-Jones T, Hyman BT. P2-164: In vivo multiphoton imaging of neurofibrillary tangles: Relationship to cell death cascades Alzheimer's & Dementia. 4: T418-T418. DOI: 10.1016/J.Jalz.2008.05.1238  0.431
2008 Meyer-Luehmann M, Stoothoff W, Spires-Jones TL, Kowa T, Koker M, Han K, Hyman BT. P1-486: Decreased neuronal activity in APP transgenic mice measured via dendritic protein synthesis Alzheimer's & Dementia. 4: T362-T362. DOI: 10.1016/J.Jalz.2008.05.1069  0.484
2007 Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. The American Journal of Pathology. 171: 1304-11. PMID 17717139 DOI: 10.2353/Ajpath.2007.070055  0.629
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