Curt R. Freed - Publications

Affiliations: 
University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Neuroscience Biology, Molecular Biology

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Greene PE, Fahn S, Eidelberg D, Bjugstad KB, Breeze RE, Freed CR. Persistent dyskinesias in patients with fetal tissue transplantation for Parkinson disease. Npj Parkinson's Disease. 7: 38. PMID 33893319 DOI: 10.1038/s41531-021-00183-w  0.651
2017 Zhou W, Barkow JC, Freed CR. Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease. Plos One. 12: e0190160. PMID 29272304 DOI: 10.1371/Journal.Pone.0190160  0.324
2016 Gao L, Zhou W, Symmes B, Freed CR. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. Plos One. 11: e0160847. PMID 27512998 DOI: 10.1371/Journal.Pone.0160847  0.393
2012 Lee KS, Zhou W, Scott-McKean JJ, Emmerling KL, Cai GY, Krah DL, Costa AC, Freed CR, Levin MJ. Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection. Plos One. 7: e53010. PMID 23285249 DOI: 10.1371/Journal.Pone.0053010  0.332
2011 Freed CR, Zhou W, Breeze RE. Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 8: 549-61. PMID 21997523 DOI: 10.1007/S13311-011-0082-9  0.446
2011 Zhou W, Bercury K, Cummiskey J, Luong N, Lebin J, Freed CR. Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. The Journal of Biological Chemistry. 286: 14941-51. PMID 21372141 DOI: 10.1074/Jbc.M110.211029  0.698
2011 Richardson RM, Freed CR, Shimamoto SA, Starr PA. Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft. Journal of Neurology, Neurosurgery, and Psychiatry. 82: 266-71. PMID 20802212 DOI: 10.1136/Jnnp.2009.201129  0.381
2010 Ma Y, Tang C, Chaly T, Greene P, Breeze R, Fahn S, Freed C, Dhawan V, Eidelberg D. Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 7-15. PMID 20008998 DOI: 10.2967/Jnumed.109.066811  0.337
2009 Zhou W, Lee YM, Guy VC, Freed CR. Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice. Stem Cells (Dayton, Ohio). 27: 2952-61. PMID 19750538 DOI: 10.1002/Stem.216  0.434
2008 Chiba S, Lee YM, Zhou W, Freed CR. Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats. Stem Cells (Dayton, Ohio). 26: 2810-20. PMID 18772316 DOI: 10.1634/Stemcells.2008-0085  0.442
2008 Zhou W, Milder JB, Freed CR. Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease. The Journal of Biological Chemistry. 283: 9863-70. PMID 18238775 DOI: 10.1074/Jbc.M710232200  0.326
2008 Goetz CG, Wuu J, McDermott MP, Adler CH, Fahn S, Freed CR, Hauser RA, Olanow WC, Shoulson I, Tandon PK, Leurgans S. Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventions. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 690-9. PMID 18228568 DOI: 10.1002/Mds.21894  0.305
2006 Bjugstad KB, Crnic LS, Goodman SI, Freed CR. Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity Journal of Inherited Metabolic Disease. 29: 612-619. PMID 16944278 DOI: 10.1007/S10545-006-0102-9  0.623
2006 Freed CR, Zhou W. DJ-1 protects dopamine neurons by selective activation of either glutathione or heat shock protein Experimental Neurology. 198: 568. DOI: 10.1016/J.Expneurol.2006.02.041  0.334
2005 Zhou W, Freed CR. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. The Journal of Biological Chemistry. 280: 43150-8. PMID 16227205 DOI: 10.1074/Jbc.M507124200  0.4
2005 Schilling B, Bharath M M S, Row RH, Murray J, Cusack MP, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW. Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line. Molecular & Cellular Proteomics : McP. 4: 84-96. PMID 15591592 DOI: 10.1074/Mcp.M400143-Mcp200  0.336
2004 Buytaert-Hoefen KA, Alvarez E, Freed CR. Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF. Stem Cells (Dayton, Ohio). 22: 669-74. PMID 15342931 DOI: 10.1634/Stemcells.22-5-669  0.314
2004 Gordon PH, Yu Q, Qualls C, Winfield H, Dillon S, Greene PE, Fahn S, Breeze RE, Freed CR, Pullman SL. Reaction time and movement time after embryonic cell implantation in Parkinson disease. Archives of Neurology. 61: 858-61. PMID 15210522 DOI: 10.1001/Archneur.61.6.858  0.32
2004 McRae C, Cherin E, Yamazaki TG, Diem G, Vo AH, Russell D, Ellgring JH, Fahn S, Greene P, Dillon S, Winfield H, Bjugstad KB, Freed CR. Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial. Archives of General Psychiatry. 61: 412-20. PMID 15066900 DOI: 10.1001/Archpsyc.61.4.412  0.635
2004 Zhou W, Freed CR. Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity. The Journal of Biological Chemistry. 279: 10128-35. PMID 14699135 DOI: 10.1074/Jbc.M307563200  0.335
2003 Ahmadi FA, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM. The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. Journal of Neurochemistry. 87: 914-21. PMID 14622122 DOI: 10.1046/J.1471-4159.2003.02068.X  0.363
2003 Freed CR, Leehey MA, Zawada M, Bjugstad K, Thompson L, Breeze RE. Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation? Journal of Neurology. 250: III44-6. PMID 14579124 DOI: 10.1007/S00415-003-1308-5  0.673
2003 Trott CT, Fahn S, Greene P, Dillon S, Winfield H, Winfield L, Kao R, Eidelberg D, Freed CR, Breeze RE, Stern Y. Cognition following bilateral implants of embryonic dopamine neurons in PD: a double blind study. Neurology. 60: 1938-43. PMID 12821736 DOI: 10.1212/01.Wnl.0000070181.28651.3B  0.338
2003 Nahreini P, Andreatta C, Kumar B, Hanson A, Edwards-Prasad J, Freed CR, Prasad KN. Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells. Cellular and Molecular Neurobiology. 23: 27-42. PMID 12701882 DOI: 10.1023/A:1022541017085  0.308
2003 McRae C, Cherin E, Diem G, Vo AH, Ellgring JH, Russell D, Fahn S, Freed C. Does personality change as a result of fetal tissue transplantation in the brain? Journal of Neurology. 250: 282-6. PMID 12638017 DOI: 10.1007/S00415-003-0986-3  0.321
2002 Ma Y, Feigin A, Dhawan V, Fukuda M, Shi Q, Greene P, Breeze R, Fahn S, Freed C, Eidelberg D. Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Annals of Neurology. 52: 628-34. PMID 12402261 DOI: 10.1002/Ana.10359  0.417
2002 Veng LM, Bjugstad KB, Freed CR, Marrack P, Clarkson ED, Bell KP, Hutt C, Zawada WM. Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats. Cell Transplantation. 11: 5-16. PMID 12095220  0.622
2002 Freed CR. Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease? Proceedings of the National Academy of Sciences of the United States of America. 99: 1755-7. PMID 11854478 DOI: 10.1073/Pnas.062039699  0.389
2002 Zhou W, Schaack J, Zawada WM, Freed CR. Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture. Brain Research. 926: 42-50. PMID 11814405 DOI: 10.1016/S0006-8993(01)03292-9  0.337
2001 Bjugstad KB, Zawada WM, Goodman S, Freed CR. IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures. Journal of Inherited Metabolic Disease. 24: 631-47. PMID 11768583 DOI: 10.1023/A:1012706908779  0.611
2001 Nakamura T, Dhawan V, Chaly T, Fukuda M, Ma Y, Breeze R, Greene P, Fahn S, Freed C, Eidelberg D. Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease. Annals of Neurology. 50: 181-7. PMID 11506400 DOI: 10.1002/Ana.1075  0.36
2001 Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. The New England Journal of Medicine. 344: 710-9. PMID 11236774 DOI: 10.1056/Nejm200103083441002  0.434
2001 Clarkson ED, Zawada WM, Bell KP, Esplen JE, Choi PK, Heidenreich KA, Freed CR. IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands. Experimental Neurology. 168: 183-91. PMID 11170733 DOI: 10.1006/Exnr.2000.7593  0.411
2001 Zawada WM, Meintzer MK, Rao P, Marotti J, Wang X, Esplen JE, Clarkson ED, Freed CR, Heidenreich KA. Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons. Brain Research. 891: 185-96. PMID 11164822 DOI: 10.1016/S0006-8993(00)02965-6  0.429
2001 Freed C, Breeze R, Greene P, Fahn S, Tsai W, Trojanowski J, Eidelberg D. Reply to "Transplanted dopaminergic neurons: More or less?" Nature Medicine. 7: 512-513. DOI: 10.1038/87798  0.363
2000 Bjugstad KB, Goodman SI, Freed CR. Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type 1 Journal of Pediatrics. 137: 681-686. PMID 11060535 DOI: 10.1067/Mpd.2000.108954  0.613
2000 Zhou W, Huribert MS, Schaack J, Prasad KN, Freed CR. Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells Brain Research. 866: 33-43. PMID 10825478 DOI: 10.1016/S0006-8993(00)02215-0  0.411
2000 Kaddis FG, Clarkson ED, Bell KP, Choi PK, Freed CR. Co-grafts of muscle cells and mesencephalic tissue into hemiparkinsonian rats: Behavioral and histochemical effects Brain Research Bulletin. 51: 203-211. PMID 10718512 DOI: 10.1016/S0361-9230(99)00216-6  0.375
1999 Clarkson ED, Freed CR. Development of fetal neural transplantation as a treatment for Parkinson's disease Life Sciences. 65: 2427-2437. PMID 10622227 DOI: 10.1016/S0024-3205(99)00254-4  0.368
1999 Clarkson ED, Edwards-Prasad J, Freed CR, Prasad KN. Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotection Experimental Biology and Medicine. 222: 157-163. PMID 10564540 DOI: 10.1046/J.1525-1373.1999.D01-126.X  0.384
1999 Hurlbert MS, Gianani RI, Hutt C, Freed CR, Kaddis FG. Neural transplantation of hNT neurons for Huntington's disease Cell Transplantation. 8: 143-151. PMID 10338282 DOI: 10.1177/096368979900800106  0.424
1998 Prasad KN, Clarkson ED, La Rosa FG, Edwards-Prasad J, Freed CR. Efficacy of grafted immortalized dopamine neurons in an animal model of Parkinsonism: A review Molecular Genetics and Metabolism. 65: 1-9. PMID 9787089 DOI: 10.1006/Mgme.1998.2726  0.448
1998 Clarkson ED, Zawada WM, Adams FS, Bell KP, Freed CR. Strands of embryonic mesencephalic tissue show greater dopamine neuron survival and better behavioral improvement than cell suspensions after transplantation in parkinsonian rats. Brain Research. 806: 60-8. PMID 9739108 DOI: 10.1016/S0006-8993(98)00717-3  0.439
1998 Bakay RA, Boyer KL, Freed CR, Ansari AA. Immunological responses to injury and grafting in the central nervous system of nonhuman primates. Cell Transplantation. 7: 109-20. PMID 9588593 DOI: 10.1016/S0963-6897(97)00165-6  0.323
1998 Zawada WM, Cibelli JB, Choi PK, Clarkson ED, Golueke PJ, Witta SE, Bell KP, Kane J, Ponce de Leon FA, Jerry DJ, Robl JM, Freed CR, Stice SL. Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats. Nature Medicine. 4: 569-74. PMID 9585230 DOI: 10.1038/Nm0598-569  0.444
1998 Zawada WM, Zastrow DJ, Clarkson ED, Adams FS, Bell KP, Freed CR. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Research. 786: 96-103. PMID 9554968 DOI: 10.1016/S0006-8993(97)01408-X  0.428
1998 Clarkson ED, La Rosa FG, Edwards-Prasad J, Kumar S, Kumar A, Cole W, Freed CR, Prasad KN. Brain contains inhibiting factors specific to the large T-antigen gene Cancer Letters. 122: 31-36. PMID 9464488 DOI: 10.1016/S0304-3835(97)00367-4  0.338
1998 Clarkson ED, La Rosa FG, Edwards-Prasad J, Weiland DA, Witta SE, Freed CR, Prasa KN. Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells Proceedings of the National Academy of Sciences of the United States of America. 95: 1265-1270. PMID 9448320 DOI: 10.1073/Pnas.95.3.1265  0.445
1998 Kuhar MJ, Vaughan R, Uhl G, Cerruti C, Revay R, Freed C, Nirenburg M, Pickel V. Localization of dopamine transporter protein by microscopic histochemistry. Advances in Pharmacology (San Diego, Calif.). 42: 168-70. PMID 9327870 DOI: 10.1016/S1054-3589(08)60719-X  0.375
1997 Baker KK, Ramig LO, Johnson AB, Freed CR. Preliminary voice and speech analysis following fetal dopamine transplants in 5 individuals with Parkinson disease. Journal of Speech, Language, and Hearing Research : Jslhr. 40: 615-26. PMID 9210118 DOI: 10.1044/Jslhr.4003.615  0.412
1997 Kaddis FG, Clarkson ED, Weber MJ, Vandenbergh DJ, Donovan DM, Mallet J, Horellou P, Uhl GR, Freed CR. Intrastriatal grafting of Cos cells stably expressing human aromatic L-amino acid decarboxylase: neurochemical effects. Journal of Neurochemistry. 68: 1520-6. PMID 9084422 DOI: 10.1046/J.1471-4159.1997.68041520.X  0.371
1997 La Rosa FG, Adams FS, Krause GE, Meyers AD, Edwards-Prasad J, Kumar R, Freed CR, Prasad KN. Inhibition of proliferation and expression of T-antigen in SV40 large T-antigen gene-induced immortalized cells following transplantations. Cancer Letters. 113: 55-60. PMID 9065801 DOI: 10.1016/S0304-3835(96)04595-8  0.359
1996 Kaddis FG, Zawada WM, Schaack J, Freed CR. Conditioned medium from aged monkey fibroblasts stably expressing GDNF and BDNF improves survival of embryonic dopamine neurons in vitro. Cell and Tissue Research. 286: 241-7. PMID 8854893 DOI: 10.1007/S004410050693  0.351
1996 Adams FS, La Rosa FG, Kumar S, Edwards-Prasad J, Kentroti S, Vernadakis A, Freed CR, Prasad KN. Characterization and transplantation of two neuronal cell lines with dopaminergic properties. Neurochemical Research. 21: 619-27. PMID 8726972 DOI: 10.1007/Bf02527762  0.388
1996 Zawada WM, Kirschman DL, Cohen JJ, Heidenreich KA, Freed CR. Growth factors rescue embryonic dopamine neurons from programmed cell death. Experimental Neurology. 140: 60-7. PMID 8682180 DOI: 10.1006/Exnr.1996.0115  0.375
1995 Patino P, Garcia-Munoz M, Freed CR. Electrophysiology of ventromedial striatal neurons during movement. Brain Research Bulletin. 37: 481-6. PMID 7633896 DOI: 10.1016/0361-9230(95)00028-D  0.31
1995 Freed C, Revay R, Vaughan RA, Kriek E, Grant S, Uhl GR, Kuhar MJ. Dopamine transporter immunoreactivity in rat brain. The Journal of Comparative Neurology. 359: 340-9. PMID 7499533 DOI: 10.1002/Cne.903590211  0.371
1994 Prasad KN, Carvalho E, Kentroti S, Edwards-Prasad J, Freed C, Vernadakis A. Establishment and characterization of immortalized clonal cell lines from fetal rat mesencephalic tissue. In Vitro Cellular & Developmental Biology. Animal. 30: 596-603. PMID 7820310 DOI: 10.1007/Bf02631258  0.332
1993 Richards JB, Sabol KE, Kriek EH, Freed CR. Trained and amphetamine-induced circling behavior in lesioned, transplanted rats. Journal of Neural Transplantation & Plasticity. 4: 157-66. PMID 8110866 DOI: 10.1155/Np.1993.157  0.334
1990 Sabol KE, Richards JB, Freed CR. In vivo dialysis measurements of dopamine and DOPAC in rats trained to turn on a circular treadmill. Pharmacology, Biochemistry, and Behavior. 36: 21-8. PMID 2349264 DOI: 10.1016/0091-3057(90)90119-3  0.37
1990 Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, Grafton ST, Huang SC, Eidelberg D, Rottenberg DA. Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year. Archives of Neurology. 47: 505-12. PMID 2334298 DOI: 10.1001/Archneur.1990.00530050021007  0.389
1990 Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, Grafton ST, Mazziotta JC, Eidelberg D, Rottenberg DA. Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease. Progress in Brain Research. 82: 715-21. PMID 2290975 DOI: 10.1016/S0079-6123(08)62664-3  0.389
1990 Richards JB, Sabol KE, Freed CR. Unilateral dopamine depletion causes bilateral deficits in conditioned rotation in rats. Pharmacology, Biochemistry, and Behavior. 36: 217-23. PMID 2113295 DOI: 10.1016/0091-3057(90)90394-W  0.334
1989 Diana M, Garcia-Munoz M, Richards J, Freed CR. Electrophysiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats. Experimental Brain Research. 74: 625-30. PMID 2707338 DOI: 10.1007/Bf00247365  0.373
1987 Diana M, Garcia-Munoz M, Freed CR. Wire electrodes for chronic single unit recording of dopamine cells in substantia nigra pars compacta of awake rats. Journal of Neuroscience Methods. 21: 71-9. PMID 3657271 DOI: 10.1016/0165-0270(87)90103-8  0.309
1987 Bhaskaran D, Freed CR. Nucleus tractus solitarus: An evaluation by in vivo voltammetry Life Sciences. 41: 323-331. PMID 2885706 DOI: 10.1016/0024-3205(87)90156-1  0.313
1986 Bennett BA, Freed CR. Mobilization of storage pool dopamine and late ipsilateral augmentation of striatal dopamine synthesis in the trained circling rat Journal of Neurochemistry. 47: 472-476. PMID 3734789 DOI: 10.1111/J.1471-4159.1986.Tb04525.X  0.384
1986 Echizen H, Freed CR. Factors affecting in vivo electrochemistry: Electrode-tissue interaction and the ascorbate amplification effect Life Sciences. 39: 77-89. PMID 2425210 DOI: 10.1016/0024-3205(86)90440-6  0.338
1985 Freed CR, Yamamoto BK. Regional brain dopamine metabolism: A marker for the speed, direction, and posture of moving animals Science. 229: 62-65. PMID 4012312 DOI: 10.1126/Science.4012312  0.36
1984 Cheney-Thamm J, Reite M, Alianiello EA, Yamamoto BK, Capitanio JP, Freed CR. Caudate electrochemical response following amphetamine administration in pigtail monkeys. Life Sciences. 35: 1453-60. PMID 6482665 DOI: 10.1016/0024-3205(84)90161-9  0.321
1984 Yamamoto BK, Freed CR. Asymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat Brain Research. 297: 115-119. PMID 6202362 DOI: 10.1016/0006-8993(84)90547-X  0.361
1984 Morgan ME, Yamamoto BK, Freed CR. Unilateral activation of caudate tyrosine hydroxylase during voluntary circling behavior. Journal of Neurochemistry. 43: 737-41. PMID 6146659 DOI: 10.1111/J.1471-4159.1984.Tb12794.X  0.334
1982 Yamamoto BK, Lane RF, Freed CR. Normal rats trained to circle show asymmetric caudate dopamine release. Life Sciences. 30: 2155-62. PMID 7109843 DOI: 10.1016/0024-3205(82)90289-2  0.343
1982 Yamamoto BK, Freed CR. The trained circling rat: A model for inducing unilateral caudate dopamine metabolism Nature. 298: 467-468. PMID 7088191 DOI: 10.1038/298467A0  0.396
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