| Year |
Citation |
Score |
| 2022 |
Bloomingdale P, Meregalli C, Pollard K, Canta A, Chiorazzi A, Fumagalli G, Monza L, Pozzi E, Alberti P, Ballarini E, Oggioni N, Carlson L, Liu W, Ghandili M, Ignatowski TA, et al. Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain. Frontiers in Pharmacology. 12: 817236. PMID 35126148 DOI: 10.3389/fphar.2021.817236 |
0.303 |
|
| 2020 |
Benson CA, Powell HR, Liput M, Dinham S, Freedman DA, Ignatowski TA, Stachowiak EK, Stachowiak MK. Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia-Schizophrenia Increases Developmental Vulnerability to TNFα. Frontiers in Cellular Neuroscience. 14: 233. PMID 33005129 DOI: 10.3389/Fncel.2020.00233 |
0.424 |
|
| 2019 |
LaMacchia ZM, Spengler RN, Jaffari M, Abidi AH, Ahmed T, Singh N, Tobinick EL, Ignatowski TA. Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain. Brain, Behavior, and Immunity. PMID 31376497 DOI: 10.1016/J.Bbi.2019.07.036 |
0.544 |
|
| 2018 |
Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX. The imidazoline I2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochemical Pharmacology. PMID 29366977 DOI: 10.1016/J.Bcp.2018.01.032 |
0.494 |
|
| 2018 |
Ignatowski TA, Spengler RN. Targeting tumor necrosis factor in the brain relieves neuropathic pain World Journal of Anesthesiology. 7: 10-19. DOI: 10.5313/WJA.V7.I2.10 |
0.327 |
|
| 2015 |
Fasick V, Spengler RN, Samankan S, Nader ND, Ignatowski TA. The hippocampus and TNF: Common links between chronic pain and depression. Neuroscience and Biobehavioral Reviews. 53: 139-59. PMID 25857253 DOI: 10.1016/J.Neubiorev.2015.03.014 |
0.414 |
|
| 2015 |
Gerard E, Spengler RN, Bonoiu AC, Mahajan SD, Davidson BA, Ding H, Kumar R, Prasad PN, Knight PR, Ignatowski TA. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. 156: 1320-33. PMID 25851457 DOI: 10.1097/J.Pain.0000000000000181 |
0.582 |
|
| 2015 |
Ignatowski TA, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Gleason CP, Law WC, Mammen MJ, Prasad PN, Schwartz SA, Mahajan SD. Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 10: 136-52. PMID 25604667 DOI: 10.1007/S11481-015-9585-1 |
0.336 |
|
| 2014 |
Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E. Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. Cns Drugs. 28: 679-97. PMID 24861337 DOI: 10.1007/S40263-014-0174-2 |
0.396 |
|
| 2014 |
Tobinick E, Rodriguez-Romanacce H, Levine A, Ignatowski TA, Spengler RN. Immediate neurological recovery following perispinal etanercept years after brain injury. Clinical Drug Investigation. 34: 361-6. PMID 24647830 DOI: 10.1007/S40261-014-0186-1 |
0.455 |
|
| 2012 |
Martuscello RT, Spengler RN, Bonoiu AC, Davidson BA, Helinski J, Ding H, Mahajan S, Kumar R, Bergey EJ, Knight PR, Prasad PN, Ignatowski TA. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. 153: 1871-82. PMID 22770843 DOI: 10.1016/J.Pain.2012.05.028 |
0.546 |
|
| 2009 |
Nader ND, Li CM, Dosluoglu HH, Ignatowski TA, Spengler RN. Adjuvant therapy with intrathecal clonidine improves postoperative pain in patients undergoing coronary artery bypass graft. The Clinical Journal of Pain. 25: 101-6. PMID 19333153 DOI: 10.1097/Ajp.0B013E3181817Add |
0.421 |
|
| 2008 |
Sud R, Spengler RN, Nader ND, Ignatowski TA. Antinociception occurs with a reversal in alpha 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory. European Journal of Pharmacology. 588: 217-31. PMID 18514187 DOI: 10.1016/J.Ejphar.2008.04.043 |
0.769 |
|
| 2007 |
Spengler RN, Sud R, Knight PR, Ignatowski TA. Antinociception mediated by alpha(2)-adrenergic activation involves increasing tumor necrosis factor alpha (TNFalpha) expression and restoring TNFalpha and alpha(2)-adrenergic inhibition of norepinephrine release. Neuropharmacology. 52: 576-89. PMID 17055005 DOI: 10.1016/J.Neuropharm.2006.08.027 |
0.774 |
|
| 2007 |
Sud R, Ignatowski TA, Lo CP, Spengler RN. Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain. Brain, Behavior, and Immunity. 21: 112-24. PMID 16859892 DOI: 10.1016/J.Bbi.2006.06.001 |
0.766 |
|
| 2007 |
Ignatowski TA, Spengler RN. Cytokines in Synaptic Function Neuroimmune Biology. 6: 109,111-143. DOI: 10.1016/S1567-7443(07)10007-7 |
0.368 |
|
| 2005 |
Reynolds JL, Ignatowski TA, Sud R, Spengler RN. An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission. Neuroscience. 133: 519-31. PMID 15878644 DOI: 10.1016/J.Neuroscience.2005.02.023 |
0.754 |
|
| 2005 |
Ignatowski TA, Sud R, Reynolds JL, Knight PR, Spengler RN. The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha (TNF). Neuropharmacology. 48: 448-60. PMID 15721177 DOI: 10.1016/J.Neuropharm.2004.11.001 |
0.777 |
|
| 2005 |
Reynolds JL, Ignatowski TA, Spengler RN. Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor. Journal of Neuroscience Research. 79: 779-87. PMID 15672410 DOI: 10.1002/Jnr.20407 |
0.612 |
|
| 2004 |
Reynolds JL, Ignatowski TA, Gallant S, Spengler RN. Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain. Brain Research. 1023: 112-20. PMID 15364025 DOI: 10.1016/J.Brainres.2004.07.028 |
0.651 |
|
| 2004 |
Reynolds JL, Ignatowski TA, Sud R, Spengler RN. Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant. The Journal of Pharmacology and Experimental Therapeutics. 310: 1216-25. PMID 15082752 DOI: 10.1124/Jpet.104.067835 |
0.76 |
|
| 2004 |
Renauld AE, Ignatowski TA, Spengler RN. Alpha 2-adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-alpha. Brain Research. 1004: 212-6. PMID 15033439 DOI: 10.1016/J.Brainres.2004.01.029 |
0.583 |
|
| 2002 |
Ignatowski TA, Spengler RN. Tumor necrosis factor-alpha quantification and expression by in situ hybridization. Methods in Molecular Biology (Clifton, N.J.). 196: 85-96. PMID 12152221 DOI: 10.1385/1-59259-274-0:85 |
0.487 |
|
| 2002 |
Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN. Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain. Regional Anesthesia and Pain Medicine. 27: 357-66. PMID 12132059 DOI: 10.1053/Rapm.2002.31930 |
0.571 |
|
| 2001 |
Nader ND, Ignatowski TA, Kurek CJ, Knight PR, Spengler RN. Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-α during the perioperative period Anesthesia and Analgesia. 93: 363-369. PMID 11473862 DOI: 10.1213/00000539-200108000-00026 |
0.456 |
|
| 2001 |
Nickola TJ, Ignatowski TA, Reynolds JL, Spengler RN. Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-α mRNA and α2-adrenergic receptor sensitivity Journal of Pharmacology and Experimental Therapeutics. 297: 680-687. PMID 11303058 |
0.457 |
|
| 2000 |
Ignatowski TA, Kunkel SL, Spengler RN. Interactions between the alpha(2)-adrenergic and the prostaglandin response in the regulation of macrophage-derived tumor necrosis factor. Clinical Immunology (Orlando, Fla.). 96: 44-51. PMID 10873427 DOI: 10.1006/Clim.2000.4877 |
0.434 |
|
| 2000 |
Nickola TJ, Ignatowski TA, Spengler RN. Antidepressant drug administration modifies the interactive relationship between α2-adrenergic sensitivity and levels of TNF in the rat brain Journal of Neuroimmunology. 107: 50-58. PMID 10808050 DOI: 10.1016/S0165-5728(00)00244-7 |
0.534 |
|
| 2000 |
Covey WC, Ignatowski TA, Knight PR, Spengler RN. Brain-derived TNFα : Involvement in neuroplastic changes implicated in the conscious perception of persistent pain Brain Research. 859: 113-122. PMID 10720620 DOI: 10.1016/S0006-8993(00)01965-X |
0.564 |
|
| 1999 |
Zhang L, Ignatowski TA, Spengler RN, Noble B, Stinson MW. Streptococcal histone induces murine macrophages to produce interleukin- 1 and tumor necrosis factor alpha Infection and Immunity. 67: 6473-6477. PMID 10569765 DOI: 10.1128/Iai.67.12.6473-6477.1999 |
0.467 |
|
| 1999 |
Ignatowski TA, Covey WC, Knight PR, Severin CM, Nickola TJ, Spengler RN. Brain-derived TNFα mediates neuropathic pain Brain Research. 841: 70-77. PMID 10546989 DOI: 10.1016/S0006-8993(99)01782-5 |
0.549 |
|
| 1997 |
Ignatowski TA, Noble BK, Wright JR, Gorfien JL, Heffner RR, Spengler RN. Neuronal-associated tumor necrosis factor (TNF alpha): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration. Journal of Neuroimmunology. 79: 84-90. PMID 9357451 DOI: 10.1016/S0165-5728(97)00107-0 |
0.632 |
|
| 1996 |
Ignatowski TA, Gallant S, Spengler RN. Temporal regulation by adrenergic receptor stimulation of macrophage (Mφ)-derived tumor necrosis factor (TNF) production post-LPS challenge Journal of Neuroimmunology. 65: 107-117. PMID 8964892 DOI: 10.1016/0165-5728(96)00004-5 |
0.439 |
|
| 1996 |
Ignatowski TA, Chou RC, Spengler RN. Changes in noradrenergic sensitivity to tumor necrosis factor-α in brains of rats administered clonidine Journal of Neuroimmunology. 70: 55-63. PMID 8862135 DOI: 10.1016/S0165-5728(96)00098-7 |
0.522 |
|
| 1995 |
Ignatowski TA, Spengler RN. Regulation of macrophage-derived tumor necrosis factor production by modification of adrenergic receptor sensitivity Journal of Neuroimmunology. 61: 61-70. PMID 7560013 DOI: 10.1016/0165-5728(95)00074-C |
0.451 |
|
| 1994 |
Ignatowski TA, Spengler RN. Tumor necrosis factor-α: presynaptic sensitivity is modified after antidepressant drug administration Brain Research. 665: 293-299. PMID 7895065 DOI: 10.1016/0006-8993(94)91350-1 |
0.554 |
|
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