Nobuyuki Nukina, M.D., Ph.D. - Publications

Laboratory for Structural Neuropathology RIKEN Brain Science Institute, Wakō-shi, Saitama-ken, Japan 
Polyglutamine diseases, Huntington disease, Protein aggregates

215 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Okuzumi A, Hatano T, Fukuhara T, Ueno S, Nukina N, Imai Y, Hattori N. α-Synuclein Seeding Assay Using RT-QuIC. Methods in Molecular Biology (Clifton, N.J.). 2322: 3-16. PMID 34043187 DOI: 10.1007/978-1-0716-1495-2_1  0.6
2020 Kasahara J, Imamura Y, Hiyama A, Yamanaka T, Miyazaki H, Nukina N. Proteomic Analysis of Subcellular Compartments Containing Disseminated Alpha-synuclein Seeds. Neuroscience Research. PMID 33309865 DOI: 10.1016/j.neures.2020.11.009  1
2020 Yamanaka T, Miyazaki H, Tosaki A, Maity SN, Shimogori T, Hattori N, Nukina N. Gene expression profiling in neuronal cells identifies a different type of transcriptome modulated by NF-Y. Scientific Reports. 10: 21714. PMID 33303918 DOI: 10.1038/s41598-020-78682-8  1
2020 Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y. CELF2 regulates the species-specific alternative splicing of TREM2. Scientific Reports. 10: 17995. PMID 33093587 DOI: 10.1038/s41598-020-75057-x  0.8
2020 Miyazaki H, Yamanaka T, Oyama F, Kino Y, Kurosawa M, Yamada-Kurosawa M, Yamano R, Shimogori T, Hattori N, Nukina N. FACS array-based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model. The Journal of Biological Chemistry. PMID 32499373 DOI: 10.1074/Jbc.Ra120.012983  1
2020 Yamanaka T, Nishiyama R, Shimogori T, Nukina N. Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. Scientific Reports. 10: 7610. PMID 32376919 DOI: 10.1038/S41598-020-64517-Z  1
2019 Yoshinaga S, Yamanaka T, Miyazaki H, Okuzumi A, Hiyama A, Murayama S, Nukina N. Preserved proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to disease-related structural study. Biochemical and Biophysical Research Communications. PMID 31785806 DOI: 10.1016/J.Bbrc.2019.11.142  1
2019 Tanaka G, Yamanaka T, Furukawa Y, Kajimura N, Mitsuoka K, Nukina N. Sequence- and seed-structure-dependent polymorphic fibrils of alpha-synuclein. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 30790619 DOI: 10.1016/J.Bbadis.2019.02.013  1
2019 Tanaka G, Yamanaka T, Furukawa Y, Kajimura N, Mitsuoka K, Nukina N. Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates. Biochemical and Biophysical Research Communications. 508: 729-734. PMID 30528390 DOI: 10.1016/J.Bbrc.2018.11.200  1
2018 Park H, Miyazaki H, Yamanaka T, Nukina N. Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice. Neuroscience Research. PMID 30391555 DOI: 10.1016/J.Neures.2018.10.013  1
2018 Okuzumi A, Kurosawa M, Hatano T, Takanashi M, Nojiri S, Fukuhara T, Yamanaka T, Miyazaki H, Yoshinaga S, Furukawa Y, Shimogori T, Hattori N, Nukina N. Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment. Acta Neuropathologica Communications. 6: 96. PMID 30231908 DOI: 10.1186/S40478-018-0587-0  1
2018 Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T. TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes. Plos One. 13: e0200988. PMID 30086173 DOI: 10.1371/Journal.Pone.0200988  0.72
2018 Matsumoto G, Inobe T, Amano T, Murai K, Nukina N, Mori N. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Scientific Reports. 8: 9585. PMID 29941919 DOI: 10.1038/S41598-018-27872-6  0.64
2018 Yamanaka T, Nukina N. ER Dynamics and Derangement in Neurological Diseases. Frontiers in Neuroscience. 12: 91. PMID 29515361 DOI: 10.3389/Fnins.2018.00091  1
2017 Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S. Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion. The Journal of Biological Chemistry. PMID 28655765 DOI: 10.1074/Jbc.M117.786509  0.72
2017 Tanaka M, Ishizuka K, Nekooki-Machida Y, Endo R, Takashima N, Sasaki H, Komi Y, Gathercole A, Huston E, Ishii K, Hui KK, Kurosawa M, Kim SH, Nukina N, Takimoto E, et al. Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease. The Journal of Clinical Investigation. PMID 28263187 DOI: 10.1172/Jci85594  0.72
2016 Ohno M, Kimura M, Miyazaki H, Okawa K, Onuki R, Nemoto C, Tabata E, Wakita S, Kashimura A, Sakaguchi M, Sugahara Y, Nukina N, Bauer PO, Oyama F. Acidic mammalian chitinase is a proteases-resistant glycosidase in mouse digestive system. Scientific Reports. 6: 37756. PMID 27883045 DOI: 10.1038/Srep37756  0.72
2016 Kino Y, Washizu C, Kurosawa M, Yamada M, Doi H, Takumi T, Adachi H, Katsuno M, Sobue G, Hicks GG, Hattori N, Shimogori T, Nukina N. FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice. Scientific Reports. 6: 35236. PMID 27739513 DOI: 10.1038/Srep35236  0.8
2016 Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Koike M, Uchiyama Y, Maity SN, Misawa H, Takahashi R, Shimogori T, Hattori N, Nukina N. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Scientific Reports. 6: 34575. PMID 27687130 DOI: 10.1038/Srep34575  1
2016 Misawa H, Inomata D, Kikuchi M, Maruyama S, Moriwaki Y, Okuda T, Nukina N, Yamanaka T. Reappraisal of VAChT-Cre: Preference in Slow Motor Neurons Innervating Type I or IIa Muscle Fibers. Genesis (New York, N.Y. : 2000). PMID 27596971 DOI: 10.1002/Dvg.22979  1
2016 Shimizu H, Miyazaki H, Ohsawa N, Shoji S, Ishizuka-Katsura Y, Tosaki A, Oyama F, Terada T, Sakamoto K, Shirouzu M, Sekine S, Nukina N, Yokoyama S. Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits. Scientific Reports. 6: 26618. PMID 27216889 DOI: 10.1038/Srep26618  0.72
2016 Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y, Arandel L, Jollet A, Thibault C, Philipps M, Vicaire S, Jost B, Udd B, Day JW, ... ... Nukina N, et al. Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy. Nature Communications. 7: 11067. PMID 27063795 DOI: 10.1038/Ncomms11067  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nukina N, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.56
2016 Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C. Proteomic Analysis of Native Cerebellar iFGF14 Complexes. Channels (Austin, Tex.). 0. PMID 26889602 DOI: 10.1080/19336950.2016.1153203  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nukina N, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.44
2016 Yamanaka T, Tosaki A, Kurosawa M, Shimogori T, Hattori N, Nukina N. Genome-wide analyses in neuronal cells reveal that USF transcription factors regulate lysosomal gene expression. The Febs Journal. PMID 26756308 DOI: 10.1111/Febs.13650  1
2015 Inobe T, Nozaki M, Nukina N. Artificial regulation of p53 function by modulating its assembly. Biochemical and Biophysical Research Communications. 467: 322-7. PMID 26454170 DOI: 10.1016/J.Bbrc.2015.09.162  1
2015 Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. Plos Genetics. 11: e1005503. PMID 26355680 DOI: 10.1371/Journal.Pgen.1005503  1
2015 Kurosawa M, Matsumoto G, Sumikura H, Hatsuta H, Murayama S, Sakurai T, Shimogori T, Hattori N, Nukina N. Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases. Neuroscience Research. PMID 26302676 DOI: 10.1016/J.Neures.2015.08.002  1
2015 Ogawa M, Shidara H, Oka K, Kurosawa M, Nukina N, Furukawa Y. Cysteine residues in Cu,Zn-superoxide dismutase are essential to toxicity in Caenorhabditis elegans model of amyotrophic lateral sclerosis. Biochemical and Biophysical Research Communications. 463: 1196-202. PMID 26086102 DOI: 10.1016/J.Bbrc.2015.06.084  0.72
2015 Matsumoto G, Shimogori T, Hattori N, Nukina N. TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation. Human Molecular Genetics. 24: 4429-42. PMID 25972374 DOI: 10.1093/Hmg/Ddv179  0.64
2015 Kino Y, Washizu C, Kurosawa M, Yamada M, Miyazaki H, Akagi T, Hashikawa T, Doi H, Takumi T, Hicks GG, Hattori N, Shimogori T, Nukina N. FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 3: 24. PMID 25907258 DOI: 10.1186/S40478-015-0202-6  0.8
2015 Wimmer VC, Harty RC, Richards KL, Phillips AM, Miyazaki H, Nukina N, Petrou S. Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain. The Journal of Comparative Neurology. 523: 814-30. PMID 25421039 DOI: 10.1002/Cne.23715  1
2015 Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N. Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice. Human Molecular Genetics. 24: 1092-105. PMID 25305080 DOI: 10.1093/Hmg/Ddu522  1
2015 Kino Y, Washizu C, Kurosawa M, Oma Y, Hattori N, Ishiura S, Nukina N. Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins. Human Molecular Genetics. 24: 740-56. PMID 25274774 DOI: 10.1093/Hmg/Ddu492  1
2015 Ogawa M, Shidara H, Oka K, Kurosawa M, Nukina N, Furukawa Y. Cysteine residues in Cu,Zn-superoxide dismutase are essential to toxicity in Caenorhabditis elegans model of amyotrophic lateral sclerosis Biochemical and Biophysical Research Communications. 463: 1196-1202. DOI: 10.1016/j.bbrc.2015.06.084  1
2014 Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y. Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. Plos Genetics. 10: e1004861. PMID 25474007 DOI: 10.1371/Journal.Pgen.1004861  1
2014 Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, ... ... Nukina N, et al. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nature Communications. 5: 5525. PMID 25413837 DOI: 10.1038/Ncomms6525  1
2014 Hamada K, Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Hisatsune C, Nakamura T, Mikoshiba K. Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors. Proceedings of the National Academy of Sciences of the United States of America. 111: E3966-75. PMID 25201980 DOI: 10.1073/Pnas.1409730111  1
2014 Chhangani D, Nukina N, Kurosawa M, Amanullah A, Joshi V, Upadhyay A, Mishra A. Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity. Biochimica Et Biophysica Acta. 1842: 1472-84. PMID 24769000 DOI: 10.1016/J.Bbadis.2014.04.014  1
2014 Yamanaka T, Wong HK, Tosaki A, Bauer PO, Wada K, Kurosawa M, Shimogori T, Hattori N, Nukina N. Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation. Plos One. 9: e93891. PMID 24705917 DOI: 10.1371/Journal.Pone.0093891  1
2014 Yamanaka T, Tosaki A, Kurosawa M, Matsumoto G, Koike M, Uchiyama Y, Maity SN, Shimogori T, Hattori N, Nukina N. NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nature Communications. 5: 3354. PMID 24566496 DOI: 10.1038/Ncomms4354  1
2014 Asada A, Yamazaki R, Kino Y, Saito T, Kimura T, Miyake M, Hasegawa M, Nukina N, Hisanaga S. Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2. Neuroscience Letters. 563: 112-7. PMID 24486837 DOI: 10.1016/J.Neulet.2014.01.046  1
2014 Maheshwari M, Bhutani S, Das A, Mukherjee R, Sharma A, Kino Y, Nukina N, Jana NR. Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease. Human Molecular Genetics. 23: 2737-51. PMID 24381308 DOI: 10.1093/Hmg/Ddt667  1
2014 Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y. Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 289: 1192-202. PMID 24280224 DOI: 10.1074/Jbc.M113.516492  1
2013 Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno S, Hattori N, Nukina N. Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. Plos One. 8: e84036. PMID 24391875 DOI: 10.1371/Journal.Pone.0084036  1
2013 Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N. Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis. Febs Letters. 587: 2500-5. PMID 23831581 DOI: 10.1016/J.Febslet.2013.06.046  1
2013 Furukawa Y, Nukina N. Functional diversity of protein fibrillar aggregates from physiology to RNA granules to neurodegenerative diseases. Biochimica Et Biophysica Acta. 1832: 1271-8. PMID 23597596 DOI: 10.1016/J.Bbadis.2013.04.011  1
2013 Ikeda T, Kurosawa M, Morimoto C, Kitayama S, Nukina N. Multiple effects of repetitive transcranial magnetic stimulation on neuropsychiatric disorders. Biochemical and Biophysical Research Communications. 436: 121-7. PMID 23524259 DOI: 10.1016/J.Bbrc.2013.03.017  1
2013 Bauer PO, Nukina N. Chaperone-Mediated Autophagy and Degradation of Mutant Huntingtin Protein Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 369-382. DOI: 10.1016/B978-0-12-405877-4.00026-3  1
2012 Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proceedings of the National Academy of Sciences of the United States of America. 109: 18577-82. PMID 23090990 DOI: 10.1073/Pnas.1209142109  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Nukina N, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.64
2012 Bauer PO, Hudec R, Goswami A, Kurosawa M, Matsumoto G, Mikoshiba K, Nukina N. ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT. Molecular Neurodegeneration. 7: 43. PMID 22929228 DOI: 10.1186/1750-1326-7-43  1
2012 Mitomi Y, Nomura T, Kurosawa M, Nukina N, Furukawa Y. Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates. The Journal of Biological Chemistry. 287: 34764-75. PMID 22891249 DOI: 10.1074/Jbc.M112.387035  1
2012 Ding F, Furukawa Y, Nukina N, Dokholyan NV. Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates. Journal of Molecular Biology. 421: 548-60. PMID 22210350 DOI: 10.1016/J.Jmb.2011.12.029  1
2011 Nukina N. [Neurodegeration based on polyglutamine aggregation]. Rinshō Shinkeigaku = Clinical Neurology. 51: 976-8. PMID 22277447 DOI: 10.5692/Clinicalneurol.51.976  1
2011 Bauer PO, Hudec R, Ozaki S, Okuno M, Ebisui E, Mikoshiba K, Nukina N. Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation. Biochemical and Biophysical Research Communications. 416: 13-7. PMID 22056561 DOI: 10.1016/J.Bbrc.2011.10.096  1
2011 Matsumoto G, Wada K, Okuno M, Kurosawa M, Nukina N. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Molecular Cell. 44: 279-89. PMID 22017874 DOI: 10.1016/J.Molcel.2011.07.039  1
2011 Furukawa Y, Kaneko K, Nukina N. Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site. Biochimica Et Biophysica Acta. 1812: 1577-83. PMID 21946215 DOI: 10.1016/J.Bbadis.2011.09.005  1
2011 Doi H, Yoshida K, Yasuda T, Fukuda M, Fukuda Y, Morita H, Ikeda S, Kato R, Tsurusaki Y, Miyake N, Saitsu H, Sakai H, Miyatake S, Shiina M, Nukina N, et al. Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation. American Journal of Human Genetics. 89: 320-7. PMID 21835308 DOI: 10.1016/J.Ajhg.2011.07.012  1
2011 Furukawa Y, Kaneko K, Nukina N. Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties. The Journal of Biological Chemistry. 286: 27236-46. PMID 21659525 DOI: 10.1074/Jbc.M111.248963  1
2011 Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N. A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions. The Journal of Biological Chemistry. 286: 18664-72. PMID 21454603 DOI: 10.1074/Jbc.M111.231209  1
2011 Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N. Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations. Nucleic Acids Research. 39: 2781-98. PMID 21109527 DOI: 10.1093/Nar/Gkq1162  1
2010 Nukina N. [FUS/TLS as a polyglutamine aggregate interacting protein]. Rinshō Shinkeigaku = Clinical Neurology. 50: 945-7. PMID 21921521 DOI: 10.5692/Clinicalneurol.50.945  1
2010 Higo T, Hamada K, Hisatsune C, Nukina N, Hashikawa T, Hattori M, Nakamura T, Mikoshiba K. Mechanism of ER stress-induced brain damage by IP(3) receptor. Neuron. 68: 865-78. PMID 21145001 DOI: 10.1016/J.Neuron.2010.11.010  1
2010 Nishimura Y, Yalgin C, Akimoto S, Doumanis J, Sasajima R, Nukina N, Miyakawa H, Moore AW, Morimoto T. Selection of behaviors and segmental coordination during larval locomotion is disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model. Journal of Neurogenetics. 24: 194-206. PMID 21087194 DOI: 10.3109/01677063.2010.514367  1
2010 Yamanaka T, Nukina N. Transcription factor sequestration by polyglutamine proteins. Methods in Molecular Biology (Clifton, N.J.). 648: 215-29. PMID 20700715 DOI: 10.1007/978-1-60761-756-3_14  1
2010 Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei E, Wang G. Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death and Differentiation. 17: 1773-84. PMID 20467442 DOI: 10.1038/Cdd.2010.55  1
2010 Furukawa Y, Kaneko K, Yamanaka K, Nukina N. Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 285: 22221-31. PMID 20404329 DOI: 10.1074/Jbc.M110.113597  1
2010 Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N. Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nature Biotechnology. 28: 256-63. PMID 20190739 DOI: 10.1038/Nbt.1608  1
2010 Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Furukawa Y, Yamada M, Nukina N. Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction. Human Molecular Genetics. 19: 2099-112. PMID 20185558 DOI: 10.1093/Hmg/Ddq087  1
2010 Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 107: 2283-8. PMID 20133873 DOI: 10.1073/Pnas.0909434107  1
2010 Tateishi T, Hokonohara T, Yamasaki R, Miura S, Kikuchi H, Iwaki A, Tashiro H, Furuya H, Nagara Y, Ohyagi Y, Nukina N, Iwaki T, Fukumaki Y, Kira J. Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation. Acta Neuropathologica. 119: 355-64. PMID 19967541 DOI: 10.1007/S00401-009-0621-1  1
2010 Doi H, Koyano S, Suzuki Y, Nukina N, Kuroiwa Y. The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases. Neuroscience Research. 66: 131-3. PMID 19833157 DOI: 10.1016/J.Neures.2009.10.004  1
2009 Tsutsui H, Shimizu H, Mizuno H, Nukina N, Furuta T, Miyawaki A. The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins. Chemistry & Biology. 16: 1140-7. PMID 19942137 DOI: 10.1016/J.Chembiol.2009.10.010  1
2009 Doumanis J, Wada K, Kino Y, Moore AW, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. Plos One. 4: e7275. PMID 19789644 DOI: 10.1371/Journal.Pone.0007275  1
2009 Kino Y, Washizu C, Oma Y, Onishi H, Nezu Y, Sasagawa N, Nukina N, Ishiura S. MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1. Nucleic Acids Research. 37: 6477-90. PMID 19720736 DOI: 10.1093/Nar/Gkp681  1
2009 Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Miyazaki H, Nukina N, Oyama F, De Jonghe P, Isom LL. A functional null mutation of SCN1B in a patient with Dravet syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10764-78. PMID 19710327 DOI: 10.1523/Jneurosci.2475-09.2009  1
2009 Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H. Knock-down of PQBP1 impairs anxiety-related cognition in mouse. Human Molecular Genetics. 18: 4239-54. PMID 19661183 DOI: 10.1093/Hmg/Ddp378  1
2009 Bauer PO, Nukina N. The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies. Journal of Neurochemistry. 110: 1737-65. PMID 19650870 DOI: 10.1111/J.1471-4159.2009.06302.X  1
2009 Nekooki-Machida Y, Kurosawa M, Nukina N, Ito K, Oda T, Tanaka M. Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 9679-84. PMID 19487684 DOI: 10.1073/Pnas.0812083106  1
2009 Chang WH, Tien CL, Chen TJ, Nukina N, Hsieh M. Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease. Neuroscience Letters. 454: 152-6. PMID 19429074 DOI: 10.1016/J.Neulet.2009.03.004  1
2009 Bauer PO, Nukina N. Enhanced degradation of mutant huntingtin by rho kinase inhibition is mediated through activation of proteasome and macroautophagy. Autophagy. 5: 747-8. PMID 19411823 DOI: 10.4161/Auto.5.5.8704  1
2009 Remme CA, Scicluna BP, Verkerk AO, Amin AS, van Brunschot S, Beekman L, Deneer VH, Chevalier C, Oyama F, Miyazaki H, Nukina N, Wilders R, Escande D, Houlgatte R, Wilde AA, et al. Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy. Circulation Research. 104: 1283-92. PMID 19407241 DOI: 10.1161/Circresaha.109.194423  1
2009 Furukawa Y, Kaneko K, Matsumoto G, Kurosawa M, Nukina N. Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5153-62. PMID 19386911 DOI: 10.1523/Jneurosci.0783-09.2009  1
2009 Bauer PO, Wong HK, Oyama F, Goswami A, Okuno M, Kino Y, Miyazaki H, Nukina N. Inhibition of Rho kinases enhances the degradation of mutant huntingtin. The Journal of Biological Chemistry. 284: 13153-64. PMID 19278999 DOI: 10.1074/Jbc.M809229200  1
2009 Iwata A, Nagashima Y, Matsumoto L, Suzuki T, Yamanaka T, Date H, Deoka K, Nukina N, Tsuji S. Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system. The Journal of Biological Chemistry. 284: 9796-803. PMID 19218238 DOI: 10.1074/Jbc.M809739200  1
2009 Godavarthi SK, Narender D, Mishra A, Goswami A, Rao SN, Nukina N, Jana NR. Induction of chemokines, MCP-1, and KC in the mutant huntingtin expressing neuronal cells because of proteasomal dysfunction. Journal of Neurochemistry. 108: 787-95. PMID 19187096 DOI: 10.1111/J.1471-4159.2008.05823.X  1
2009 Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T. Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. Human Molecular Genetics. 18: 942-55. PMID 19088126 DOI: 10.1093/Hmg/Ddn422  1
2008 Chen X, Tang TS, Tu H, Nelson O, Pook M, Hammer R, Nukina N, Bezprozvanny I. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12713-24. PMID 19036964 DOI: 10.1523/Jneurosci.3909-08.2008  1
2008 Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N. Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. The Journal of Cell Biology. 183: 339-52. PMID 18936252 DOI: 10.1083/Jcb.200804075  1
2008 Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S. Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8747-55. PMID 18753376 DOI: 10.1523/Jneurosci.0973-08.2008  1
2008 Wang HQ, Imai Y, Inoue H, Kataoka A, Iita S, Nukina N, Takahashi R. Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss. Journal of Neurochemistry. 107: 171-85. PMID 18691389 DOI: 10.1111/J.1471-4159.2008.05607.X  1
2008 Wong HK, Bauer PO, Kurosawa M, Goswami A, Washizu C, Machida Y, Tosaki A, Yamada M, Knöpfel T, Nakamura T, Nukina N. Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism. Human Molecular Genetics. 17: 3223-35. PMID 18658163 DOI: 10.1093/Hmg/Ddn218  1
2008 Fujiwara M, Marusawa H, Wang HQ, Iwai A, Ikeuchi K, Imai Y, Kataoka A, Nukina N, Takahashi R, Chiba T. Parkin as a tumor suppressor gene for hepatocellular carcinoma. Oncogene. 27: 6002-11. PMID 18574468 DOI: 10.1038/Onc.2008.199  1
2008 Furukawa Y, Kaneko K, Yamanaka K, O'Halloran TV, Nukina N. Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 283: 24167-76. PMID 18552350 DOI: 10.1074/Jbc.M802083200  1
2008 Wong ES, Tan JM, Soong WE, Hussein K, Nukina N, Dawson VL, Dawson TM, Cuervo AM, Lim KL. Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Human Molecular Genetics. 17: 2570-82. PMID 18502787 DOI: 10.1093/Hmg/Ddn157  1
2008 Shimizu H, Tosaki A, Kaneko K, Hisano T, Sakurai T, Nukina N. Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. Molecular and Cellular Biology. 28: 3663-71. PMID 18378702 DOI: 10.1128/Mcb.02185-07  1
2008 Yamanaka T, Miyazaki H, Oyama F, Kurosawa M, Washizu C, Doi H, Nukina N. Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor. The Embo Journal. 27: 827-39. PMID 18288205 DOI: 10.1038/Emboj.2008.23  1
2008 Khan LA, Yamanaka T, Nukina N. Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans. Biochemical and Biophysical Research Communications. 368: 729-35. PMID 18261464 DOI: 10.1016/J.Bbrc.2008.01.150  1
2008 Mishra A, Dikshit P, Purkayastha S, Sharma J, Nukina N, Jana NR. E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity. The Journal of Biological Chemistry. 283: 7648-56. PMID 18201976 DOI: 10.1074/Jbc.M706620200  1
2008 Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, Nukina N. RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells. The Journal of Biological Chemistry. 283: 6489-500. PMID 18167354 DOI: 10.1074/Jbc.M705306200  1
2008 Nukina N. Pathomechanism of polyglutamine diseases and strategic design for their therapies Clinical Neurology. 48: 913-914.  1
2007 Chen C, Dickendesher TL, Oyama F, Miyazaki H, Nukina N, Isom LL. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b. Genesis (New York, N.Y. : 2000). 45: 547-53. PMID 17868089 DOI: 10.1002/Dvg.20324  1
2007 Zhang T, Jia N, Fei E, Wang P, Liao Z, Ding L, Yan M, Nukina N, Zhou J, Wang G. Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells. Neuroscience Letters. 423: 118-22. PMID 17681692 DOI: 10.1016/J.Neulet.2007.06.041  1
2007 Miyazaki H, Oyama F, Wong HK, Kaneko K, Sakurai T, Tamaoka A, Nukina N. BACE1 modulates filopodia-like protrusions induced by sodium channel beta4 subunit. Biochemical and Biophysical Research Communications. 361: 43-8. PMID 17644063 DOI: 10.1016/J.Bbrc.2007.06.170  1
2007 Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, Ihara Y. Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. Journal of Neurochemistry. 101: 949-58. PMID 17472586 DOI: 10.1111/J.1471-4159.2006.04400.X  1
2007 Iida J, Ishizaki H, Okamoto-Tanaka M, Kawata A, Sumita K, Ohgake S, Sato Y, Yorifuji H, Nukina N, Ohashi K, Mizuno K, Tsutsumi T, Mizoguchi A, Miyoshi J, Takai Y, et al. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites. Molecular and Cellular Biology. 27: 4388-405. PMID 17438139 DOI: 10.1128/Mcb.01901-06  1
2007 Fei E, Jia N, Zhang T, Ma X, Wang H, Liu C, Zhang W, Ding L, Nukina N, Wang G. Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3. Biochemical and Biophysical Research Communications. 357: 487-92. PMID 17434145 DOI: 10.1016/J.Bbrc.2007.03.160  1
2007 Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, Wang G. Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. The Journal of Biological Chemistry. 282: 14558-66. PMID 17360705 DOI: 10.1074/Jbc.M700422200  1
2007 Wang H, Jia N, Fei E, Wang Z, Liu C, Zhang T, Fan J, Wu M, Chen L, Nukina N, Zhou J, Wang G. p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome. Journal of Neurochemistry. 101: 1651-61. PMID 17302910 DOI: 10.1111/J.1471-4159.2007.04460.X  1
2007 Tsukamoto K, Shimizu H, Ishida T, Akiyama Y, Nukina N. Evaluation for interaction energy between glutamine and various chemical compounds for developing the virtual screening system using DFT quantum chemical calculations Wseas Transactions On Computers. 6: 636-641.  1
2006 Bennett EJ, Shaler T, Gonzalez-Zulueta M, Schulman HF, Iwata A, Riley BE, Johnston JA, Bucci M, Nukina N, Ellerby L, Kopito RR. Cellular mechanisms of protein quality control. Rinshō Shinkeigaku = Clinical Neurology. 46: 805. PMID 17432184  1
2006 Mitsui K, Doi H, Nukina N. Proteomics of polyglutamine aggregates. Methods in Enzymology. 412: 63-76. PMID 17046652 DOI: 10.1016/S0076-6879(06)12005-4  1
2006 Goswami A, Dikshit P, Mishra A, Nukina N, Jana NR. Expression of expanded polyglutamine proteins suppresses the activation of transcription factor NFkappaB. The Journal of Biological Chemistry. 281: 37017-24. PMID 17028181 DOI: 10.1074/Jbc.M608095200  1
2006 Khan LA, Bauer PO, Miyazaki H, Lindenberg KS, Landwehrmeyer BG, Nukina N. Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans. Journal of Neurochemistry. 98: 576-87. PMID 16805848 DOI: 10.1111/J.1471-4159.2006.03895.X  1
2006 Oyama F, Miyazaki H, Sakamoto N, Becquet C, Machida Y, Kaneko K, Uchikawa C, Suzuki T, Kurosawa M, Ikeda T, Tamaoka A, Sakurai T, Nukina N. Sodium channel beta4 subunit: down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice. Journal of Neurochemistry. 98: 518-29. PMID 16805843 DOI: 10.1111/J.1471-4159.2006.03893.X  1
2006 Machida Y, Okada T, Kurosawa M, Oyama F, Ozawa K, Nukina N. rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse. Biochemical and Biophysical Research Communications. 343: 190-7. PMID 16530728 DOI: 10.1016/J.Bbrc.2006.02.141  1
2006 Dikshit P, Goswami A, Mishra A, Nukina N, Jana NR. Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction. Biochemical and Biophysical Research Communications. 342: 1323-8. PMID 16516148 DOI: 10.1016/J.Bbrc.2006.02.104  1
2006 Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. Biochemical and Biophysical Research Communications. 342: 184-90. PMID 16472774 DOI: 10.1016/J.Bbrc.2006.01.136  1
2006 Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, Julien JP. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nature Neuroscience. 9: 108-18. PMID 16369483 DOI: 10.1038/Nn1603  1
2006 Tsukamoto K, Shimizu H, Ishida T, Akiyama Y, Nukina N. Aggregation mechanism of polyglutamine diseases revealed using quantum chemical calculations, fragment molecular orbital calculations, molecular dynamics simulations, and binding free energy calculations Journal of Molecular Structure: Theochem. 778: 85-95. DOI: 10.1016/J.Theochem.2006.08.046  1
2005 Iwata A, Christianson JC, Bucci M, Ellerby LM, Nukina N, Forno LS, Kopito RR. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proceedings of the National Academy of Sciences of the United States of America. 102: 13135-40. PMID 16141322 DOI: 10.1073/Pnas.0505801102  1
2005 Chang WH, Cemal CK, Hsu YH, Kuo CL, Nukina N, Chang MH, Hu HT, Li C, Hsieh M. Dynamic expression of Hsp27 in the presence of mutant ataxin-3. Biochemical and Biophysical Research Communications. 336: 258-67. PMID 16126176 DOI: 10.1016/J.Bbrc.2005.08.065  1
2005 Bauer PO, Kotliarova SE, Matoska V, Musova Z, Hedvicakova P, Boday A, Tomek A, Nukina N, Goetz P. Fluorescent multiplex PCR--fast method for autosomal dominant spinocerebellar ataxias screening. Genetika. 41: 830-7. PMID 16080609 DOI: 10.1007/S11177-005-0144-3  1
2005 Kotliarova S, Jana NR, Sakamoto N, Kurosawa M, Miyazaki H, Nekooki M, Doi H, Machida Y, Wong HK, Suzuki T, Uchikawa C, Kotliarov Y, Uchida K, Nagao Y, Nagaoka U, ... ... Nukina N, et al. Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates. Journal of Neurochemistry. 93: 641-53. PMID 15836623 DOI: 10.1111/J.1471-4159.2005.03035.X  1
2005 Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N. beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. The Journal of Biological Chemistry. 280: 23009-17. PMID 15824102 DOI: 10.1074/Jbc.M414648200  1
2005 Jana NR, Nukina N. BAG-1 associates with the polyglutamine-expanded huntingtin aggregates. Neuroscience Letters. 378: 171-5. PMID 15781153 DOI: 10.1016/J.Neulet.2004.12.031  1
2005 Tanaka M, Machida Y, Nukina N. A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules. Journal of Molecular Medicine (Berlin, Germany). 83: 343-52. PMID 15759103 DOI: 10.1007/S00109-004-0632-2  1
2005 Tsutsui H, Karasawa S, Shimizu H, Nukina N, Miyawaki A. Semi-rational engineering of a coral fluorescent protein into an efficient highlighter. Embo Reports. 6: 233-8. PMID 15731765 DOI: 10.1038/Sj.Embor.7400361  1
2005 Jana NR, Dikshit P, Goswami A, Kotliarova S, Murata S, Tanaka K, Nukina N. Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. The Journal of Biological Chemistry. 280: 11635-40. PMID 15664989 DOI: 10.1074/Jbc.M412042200  1
2005 Ikeda T, Kurosawa M, Uchikawa C, Kitayama S, Nukina N. Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation. Biochemical and Biophysical Research Communications. 327: 218-24. PMID 15629452 DOI: 10.1016/J.Bbrc.2004.12.009  1
2005 Bauer PO, Kotliarova SE, Matoska V, Musova Z, Hedvicakova P, Boday A, Tomek A, Nukina N, Goetz P. Fluorescent multiplex PCR: Fast method for autosomal dominant spinocerebellar ataxias screening Russian Journal of Genetics. 41: 675-682. DOI: 10.1007/s11177-005-0144-3  1
2004 Jana NR, Nukina N. Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD. Neurotoxicity Research. 6: 523-33. PMID 15639784 DOI: 10.1007/Bf03033448  1
2004 Kitamura HW, Hamanaka H, Watanabe M, Wada K, Yamazaki C, Fujita SC, Manabe T, Nukina N. Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. Neuroscience Letters. 369: 173-8. PMID 15464259 DOI: 10.1016/J.Neulet.2004.07.084  1
2004 Nagaoka U, Kim K, Jana NR, Doi H, Maruyama M, Mitsui K, Oyama F, Nukina N. Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions. Journal of Neurochemistry. 91: 57-68. PMID 15379887 DOI: 10.1111/J.1471-4159.2004.02692.X  1
2004 Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. The Journal of Biological Chemistry. 279: 44945-54. PMID 15322084 DOI: 10.1074/Jbc.M407986200  1
2004 Doi H, Mitsui K, Kurosawa M, Machida Y, Kuroiwa Y, Nukina N. Identification of ubiquitin-interacting proteins in purified polyglutamine aggregates. Febs Letters. 571: 171-6. PMID 15280037 DOI: 10.1016/J.Febslet.2004.06.077  1
2004 Jana NR, Nukina N. Assessment of impaired proteasomal function in a cellular model of polyglutamine diseases. Methods in Molecular Biology (Clifton, N.J.). 277: 287-92. PMID 15201463 DOI: 10.1385/1-59259-804-8:287  1
2004 Amano K, Sago H, Uchikawa C, Suzuki T, Kotliarova SE, Nukina N, Epstein CJ, Yamakawa K. Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Human Molecular Genetics. 13: 1333-40. PMID 15138197 DOI: 10.1093/Hmg/Ddh154  1
2004 Khan LA, Nukina N. Molecular and functional analysis of Caenorhabditis elegans CHIP, a homologue of Mammalian CHIP. Febs Letters. 565: 11-8. PMID 15135044 DOI: 10.1016/J.Febslet.2004.03.084  1
2004 Saito Y, Ruberu NN, Harada M, Arai T, Sawabe M, Nukina N, Murayama S. In situ detection of apolipoprotein E epsilon 4 in archival human brain. Neuroreport. 15: 1113-5. PMID 15129156 DOI: 10.1097/00001756-200405190-00006  1
2004 Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. The Journal of Biological Chemistry. 279: 27272-7. PMID 15087445 DOI: 10.1074/Jbc.M401634200  1
2004 Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL. Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Molecular Cell. 14: 95-104. PMID 15068806 DOI: 10.1016/S1097-2765(04)00151-0  1
2004 Doi H, Kuroiwa Y, Doi H, Nukina N. [Huntington disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 62: 102-7. PMID 15011329  1
2004 Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, Kurosawa M, Nekooki M, Nukina N. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nature Medicine. 10: 148-54. PMID 14730359 DOI: 10.1038/Nm985  1
2004 Jana NR, Dikshit P, Goswami A, Nukina N. Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. The Journal of Biological Chemistry. 279: 11680-5. PMID 14701837 DOI: 10.1074/Jbc.M310369200  1
2003 Hoshino M, Dohmae N, Takio K, Kanazawa I, Nukina N. Identification of a novel amino-terminal fragment of amyloid precursor protein in mouse neuroblastoma Neuro2a cell. Neuroscience Letters. 353: 135-8. PMID 14664919 DOI: 10.1016/J.Neulet.2003.09.030  1
2003 Jana NR, Nukina N. Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway. Journal of Chemical Neuroanatomy. 26: 95-101. PMID 14599658 DOI: 10.1016/S0891-0618(03)00029-2  1
2003 Zemskov EA, Jana NR, Kurosawa M, Miyazaki H, Sakamoto N, Nekooki M, Nukina N. Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease. Journal of Neurochemistry. 87: 395-406. PMID 14511117 DOI: 10.1046/J.1471-4159.2003.02002.X  1
2003 Zemskov EA, Nukina N. Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease. Neuroreport. 14: 1435-8. PMID 12960759 DOI: 10.1097/00001756-200308060-00006  1
2003 Fukumoto H, Ingelsson M, GÃ¥revik N, Wahlund LO, Nukina N, Yaguchi Y, Shibata M, Hyman BT, Rebeck GW, Irizarry MC. APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. Experimental Neurology. 183: 249-53. PMID 12957508 DOI: 10.1016/S0014-4886(03)00088-8  1
2003 Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Human Molecular Genetics. 12: 2625-35. PMID 12928483 DOI: 10.1093/Hmg/Ddg283  1
2003 Wen FC, Li YH, Tsai HF, Lin CH, Li C, Liu CS, Lii CK, Nukina N, Hsieh M. Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3. Febs Letters. 546: 307-14. PMID 12832059 DOI: 10.1016/S0014-5793(03)00605-7  1
2003 Tanaka M, Machida Y, Nishikawa Y, Akagi T, Hashikawa T, Fujisawa T, Nukina N. Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization. The Journal of Biological Chemistry. 278: 34717-24. PMID 12815051 DOI: 10.1074/Jbc.M209852200  1
2003 Park TJ, Hamanaka H, Ohshima T, Watanabe N, Mikoshiba K, Nukina N. Inhibition of ubiquitin ligase Siah-1A by disabled-1. Biochemical and Biophysical Research Communications. 302: 671-8. PMID 12646221 DOI: 10.1016/S0006-291X(03)00247-X  1
2003 Lee JA, Lim CS, Lee SH, Kim H, Nukina N, Kaang BK. Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons. Journal of Neurochemistry. 85: 160-9. PMID 12641738 DOI: 10.1046/J.1471-4159.2003.01650.X  1
2002 Mitsui K, Nakayama H, Akagi T, Nekooki M, Ohtawa K, Takio K, Hashikawa T, Nukina N. Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9267-77. PMID 12417652 DOI: 10.1523/Jneurosci.22-21-09267.2002  1
2002 Tanaka M, Machida Y, Nishikawa Y, Akagi T, Morishima I, Hashikawa T, Fujisawa T, Nukina N. The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases. Biochemistry. 41: 10277-86. PMID 12162743 DOI: 10.1021/Bi0258905  1
2001 Tanaka M, Morishima I, Akagi T, Hashikawa T, Nukina N. Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases. The Journal of Biological Chemistry. 276: 45470-5. PMID 11584007 DOI: 10.1074/Jbc.M107502200  1
2001 Iwata A, Maruyama M, Kanazawa I, Nukina N. alpha-Synuclein affects the MAPK pathway and accelerates cell death. The Journal of Biological Chemistry. 276: 45320-9. PMID 11560921 DOI: 10.1074/Jbc.M103736200  1
2001 Jana NR, Zemskov EA, Wang Gh, Nukina N. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Human Molecular Genetics. 10: 1049-59. PMID 11331615 DOI: 10.1093/Hmg/10.10.1049  1
2001 Iwata A, Miura S, Kanazawa I, Sawada M, Nukina N. alpha-Synuclein forms a complex with transcription factor Elk-1. Journal of Neurochemistry. 77: 239-52. PMID 11279280 DOI: 10.1046/J.1471-4159.2001.T01-1-00232.X  1
2000 Uchida Y, Ito S, Nukina N. Sandwich ELISA for the measurement of Apo-E4 levels in serum and the estimation of the allelic status of Apo-E4 isoforms. Journal of Clinical Laboratory Analysis. 14: 260-4. PMID 11138606 DOI: 10.1002/1098-2825(20001212)14:6<260::Aid-Jcla2>3.0.Co;2-I  1
2000 Nagao Y, Ishiguro H, Nukina N. DMSO and glycerol reduce bacterial death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine tracts. Biochimica Et Biophysica Acta. 1502: 247-56. PMID 11040449 DOI: 10.1016/S0925-4439(00)00047-8  1
2000 Jana NR, Tanaka M, Wang Gh, Nukina N. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Human Molecular Genetics. 9: 2009-18. PMID 10942430 DOI: 10.1093/Hmg/9.13.2009  1
2000 Wang G, Sawai N, Kotliarova S, Kanazawa I, Nukina N. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. Human Molecular Genetics. 9: 1795-803. PMID 10915768 DOI: 10.1093/Hmg/9.12.1795  1
1999 Wang GH, Mitsui K, Kotliarova S, Yamashita A, Nagao Y, Tokuhiro S, Iwatsubo T, Kanazawa I, Nukina N. Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells. Neuroreport. 10: 2435-8. PMID 10574348 DOI: 10.1097/00001756-199908200-00001  1
1999 Nukina N. [Neuronal cell death--what we can see and what we cannot]. Rinshō Shinkeigaku = Clinical Neurology. 39: 2-3. PMID 10377783  1
1999 Nukina N. [The function of Huntington disease gene product (huntingtin) and the pathomechanism of Huntington disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 57: 905-11. PMID 10222788  1
1999 Sieradzan KA, Mechan AO, Jones L, Wanker EE, Nukina N, Mann DM. Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Experimental Neurology. 156: 92-9. PMID 10192780 DOI: 10.1006/Exnr.1998.7005  1
1998 Yamashita A, Watanabe Y, Nukina N, Yamamoto M. RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast. Cell. 95: 115-23. PMID 9778252 DOI: 10.1016/S0092-8674(00)81787-0  1
1998 Iwata A, Nakamura K, Nukina N, Kanazawa I, Iwata M. [A case of dural arteriovenous fistula accompanied by sinus occlusion. A serial study with CT scan]. Rinshō Shinkeigaku = Clinical Neurology. 38: 133-7. PMID 9619076  1
1998 Iwata A, Murata M, Nukina N, Kanazawa I. Foramen magnum syndrome caused by atlanto-occipital assimilation. Journal of the Neurological Sciences. 154: 229-31. PMID 9562315 DOI: 10.1016/S0022-510X(97)00224-4  1
1997 Nukina N. [Huntington disease]. Rinshō Shinkeigaku = Clinical Neurology. 37: 1139-40. PMID 9577671  1
1997 Tukamoto T, Nukina N, Ide K, Kanazawa I. Huntington's disease gene product, huntingtin, associates with microtubules in vitro. Brain Research. Molecular Brain Research. 51: 8-14. PMID 9427501 DOI: 10.1016/S0169-328X(97)00205-2  1
1997 Oshima Y, Takahashi S, Nagayama H, Nishiwaki K, Kobayashi Y, Tojo A, Okamoto S, Tani K, Ozawa K, Wakabayashi T, Sato N, Kobayashi S, Nakamura K, Ohya Y, Nukina N, et al. Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). Bone Marrow Transplantation. 19: 737-40. PMID 9156252 DOI: 10.1038/Sj.Bmt.1700731  1
1997 Wang G, Ide K, Nukina N, Goto J, Ichikawa Y, Uchida K, Sakamoto T, Kanazawa I. Machado-Joseph disease gene product identified in lymphocytes and brain. Biochemical and Biophysical Research Communications. 233: 476-9. PMID 9144561 DOI: 10.1006/Bbrc.1997.6484  1
1997 Yazawa I, Nukina N, Goto J, Kurisaki H, Hebisawa A, Kanazawa I. Expression of dentatorubral-pallidoluysian atrophy (DRPLA) proteins in patients. Neuroscience Letters. 225: 53-6. PMID 9143016 DOI: 10.1016/S0304-3940(97)00189-4  1
1997 Matsushima T, Nakamura K, Oka T, Tachikawa N, Sata T, Murayama S, Nukina N, Kanazawa I. Unusual MRI and pathologic findings of progressive multifocal leukoencephalopathy complicating adult Wiskott-Aldrich syndrome. Neurology. 48: 279-82. PMID 9008537 DOI: 10.1212/Wnl.48.1.279  1
1996 Yazawa I, Nukina N, Kanazawa I. Characterization of dentatorubral-pallidoluysian atrophy proteins using two-dimensional electrophoretic analysis. Brain Research. 732: 154-8. PMID 8891279 DOI: 10.1016/0006-8993(96)00515-X  1
1996 Yanagisawa H, Fujii K, Nagafuchi S, Nakahori Y, Nakagome Y, Akane A, Nakamura M, Sano A, Komure O, Kondo I, Jin DK, Sørensen SA, Potter NT, Young SR, Nakamura K, ... Nukina N, et al. A unique origin and multistep process for the generation of expanded DRPLA triplet repeats. Human Molecular Genetics. 5: 373-9. PMID 8852663 DOI: 10.1093/Hmg/5.3.373  1
1996 Kuwabara K, Hitoshi S, Nukina N, Ishii K, Momose T, Kubota S, Seyama Y, Kanazawa I. PET analysis of a case of cerebrotendinous xanthomatosis presenting hemiparkinsonism. Journal of the Neurological Sciences. 138: 145-9. PMID 8791252 DOI: 10.1016/0022-510X(96)00011-1  1
1996 Yazawa I, Nukina N, Ichikawa Y, Kanazawa I. Dentatorubral-pallidoluysian atrophy proteins in lymphoblastoid cells. Neurology. 47: 586-8. PMID 8757047 DOI: 10.1212/Wnl.47.2.586  1
1996 Terao Y, Hashimoto K, Nukina N, Mannen T, Shinohara T. Cortical dysgenesis in a patient with Turner mosaicism. Developmental Medicine and Child Neurology. 38: 455-60. PMID 8698153 DOI: 10.1111/J.1469-8749.1996.Tb15103.X  1
1995 Ide K, Nukina N, Kanazawa I. [Huntington's disease: trinucleotide disease or polyglutamine disease?]. Rinshō Shinkeigaku = Clinical Neurology. 35: 1540-1. PMID 8752457  1
1995 Nukina N, Kanazawa I. [Cerebellar ataxia, 2) dementia, 3) syncopal attack, 4) character change]. Nō to Shinkei = Brain and Nerve. 47: 397. PMID 7772409  1
1995 Ide K, Nukina N, Masuda N, Goto J, Kanazawa I. Abnormal gene product identified in Huntington's disease lymphocytes and brain. Biochemical and Biophysical Research Communications. 209: 1119-25. PMID 7733967 DOI: 10.1006/Bbrc.1995.1613  1
1995 Nukina N, Kanazawa I. [Dementia]. Nō to Shinkei = Brain and Nerve. 47: 197-8. PMID 7669421  1
1995 Yazawa I, Nukina N, Hashida H, Goto J, Yamada M, Kanazawa I. Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain. Nature Genetics. 10: 99-103. PMID 7647802 DOI: 10.1038/Ng0595-99  1
1995 Nukina N, Uchida K, Sakamoto T, Ide K, Kanazawa I. Monoclonal antibody against the polymorphic site distinguishes apolipoprotein E4 from other isoforms. Biochemical and Biophysical Research Communications. 216: 467-72. PMID 7488135 DOI: 10.1006/Bbrc.1995.2646  1
1994 Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13: 45-53. PMID 8043280 DOI: 10.1016/0896-6273(94)90458-8  1
1994 Tamaoka A, Odaka A, Ishibashi Y, Usami M, Sahara N, Suzuki N, Nukina N, Mizusawa H, Shoji S, Kanazawa I. APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain. The Journal of Biological Chemistry. 269: 32721-4. PMID 7806491  1
1994 Hitoshi S, Kusunoki S, Chiba A, Takatsu R, Sunada Y, Nukina N, Tai T, Kanazawa I. Cerebellar ataxia and polyneuropathy in a patient with IgM M-protein specific to the Gal(beta 1-3)GalNAc epitope. Journal of the Neurological Sciences. 126: 219-24. PMID 7531761 DOI: 10.1016/0022-510X(94)90277-1  1
1993 Tanaka H, Naruse S, Seki K, Onodera O, Kobayashi H, Miyatake T, Shibata A, Sakaki Y, Kamino K, Miki T, Nukina N, Imagawa M, Nakano I, Shimizu T, Kojima T, et al. Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familia Alzheimer's disease with 717Val→Ile mutation Neuroscience Letters. 162: 63-66. PMID 8121639 DOI: 10.1016/0304-3940(93)90560-8  1
1992 Nukina N, Kanazawa I, Mannen T, Uchida Y. Accumulation of amyloid precursor protein and beta-protein immunoreactivities in axons injured by cerebral infarct. Gerontology. 38: 10-4. PMID 1459467 DOI: 10.1159/000213357  1
1992 Hashimoto K, Mannen T, Nukina N. Immunohistochemical study of kuru plaques using antibodies against synthetic prion protein peptides. Acta Neuropathologica. 83: 613-7. PMID 1353279 DOI: 10.1007/Bf00299410  1
1992 Nukina N, Quan Y, Nakano I, Otomo E. [Widespread tau abnormality in a case of cortico-basal degeneration]. Rinshō Shinkeigaku = Clinical Neurology. 32: 1093-101. PMID 1297553  1
1990 Iwatsubo T, Ishige Y, Nukina N, Mannen T. [Chronic human colchicine myopathy]. Rinshō Shinkeigaku = Clinical Neurology. 30: 1001-4. PMID 2265497  1
1990 Nukina N. [Tau protein and beta protein]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 27: 276-9. PMID 2120489  1
1989 Nukina N, Mannen T. [Abnormal proteins in the brain in Alzheimer's disease]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 34: 1725-32. PMID 2555845  1
1989 Nukina N. The reinterpretation of the immunochemical study of Alzheimer neurofibrillary tangles. Annals of Medicine. 21: 117-9. PMID 2475148 DOI: 10.3109/07853898909149197  1
1988 Nukina N, Kosik KS, Selkoe DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neuroscience Letters. 87: 240-6. PMID 3132653 DOI: 10.1016/0304-3940(88)90455-7  1
1988 Nukina N. [Biochemistry study on brain pathology in Alzheimer's disease. Biochemical approach to the etiological mechanism]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 46: 1475-83. PMID 3065524  1
1988 Kanazawa I, Kwak S, Sasaki H, Muramoto O, Mizutani T, Hori A, Nukina N. Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction. Journal of the Neurological Sciences. 83: 63-74. PMID 2450180 DOI: 10.1016/0022-510X(88)90020-2  1
1987 Nukina N, Kosik KS, Selkoe DJ. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proceedings of the National Academy of Sciences of the United States of America. 84: 3415-9. PMID 3106969 DOI: 10.1097/00002093-198701040-00025  1
1986 Mukai M, Torikata C, Iri H, Morikawa Y, Shimizu K, Shimoda T, Nukina N, Ihara Y, Kageyama K. Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. The American Journal of Pathology. 122: 28-35. PMID 3079958  1
1986 Murayama S, Nukina N, Inoue K, Iwata M, Mannen T. [An autopsy case of generalized variant of Pick's disease]. Rinshō Shinkeigaku = Clinical Neurology. 26: 1051-61. PMID 3026715  1
1986 Ihara Y, Nukina N, Miura R, Ogawara M. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. Journal of Biochemistry. 99: 1807-10. PMID 2427509 DOI: 10.1097/00002093-198701030-00016  1
1986 Sonoo M, Sakuta M, Takatsu M, Nukina N, Kusunoki S. [A case of macroglobulinemic neuropathy with biclonal IgM kappa M-proteins]. Rinshō Shinkeigaku = Clinical Neurology. 26: 379-86. PMID 2426026  1
1986 Nukina N, Ihara Y. One of the antigenic determinants of paired helical filaments is related to tau protein. Journal of Biochemistry. 99: 1541-4. PMID 2423512 DOI: 10.1093/Oxfordjournals.Jbchem.A135625  1
1985 Murayama S, Nukina N, Ihara Y, Nakazato Y, Ishida Y, Takanashi R. [Immunocytochemistry of Pick's argentophilic bodies: evidence for the involvement of high molecular weight microtubule-associated proteins (HMWP) before the appearance of tubulin]. Rinshō Shinkeigaku = Clinical Neurology. 25: 80-7. PMID 2986887  1
1985 Kanazawa I, Kwak S, Sasaki H, Mizusawa H, Muramoto O, Yoshizawa K, Nukina N, Kitamura K, Kurisaki H, Sugita K. Studies on neurotransmitter markers and neuronal cell density in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy. Journal of the Neurological Sciences. 71: 193-208. PMID 2868072 DOI: 10.1016/0022-510X(85)90059-0  1
1985 Nukina N, Ihara Y. Proteolytic fragments of Alzheimer's paired helical filaments. Journal of Biochemistry. 98: 1715-8. PMID 2419316 DOI: 10.1093/Oxfordjournals.Jbchem.A135443  1
1983 Kurisaki H, Ihara Y, Nukina N, Toyokura Y. [Immunocytochemical study of spheroid filament protein in amyotrophic lateral sclerosis using an antiserum to 200K peptide of neurofilament and anti-tubulin antibody]. Rinshō Shinkeigaku = Clinical Neurology. 23: 1013-20. PMID 6426838  1
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