Tim G. Hales - Publications

Affiliations: 
The George Washington University, Washington, DC, United States 
Area:
Neuroscience Biology, Pharmacology

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABA receptors in GtoPdb v.2021.3. Iuphar/Bps Guide to Pharmacology Cite. 2021. PMID 35005623 DOI: 10.2218/gtopdb/F72/2021.3  0.387
2020 Baptista-Hon DT, Smith M, Singleton S, Antonides LH, Nic Daeid N, McKenzie C, Hales TG. Activation of μ opioid receptors by MT-45 and its fluorinated derivatives. British Journal of Pharmacology. PMID 32246840 DOI: 10.1111/Bph.15064  0.338
2019 Hunter WN, Jones MJ, Dawson A, Hales TG. A structural rationale for N-methylbicuculline acting as a promiscuous competitive antagonist of inhibitory pentameric ligand gated ion channels. Chembiochem : a European Journal of Chemical Biology. PMID 31859406 DOI: 10.1002/Cbic.201900680  0.458
2019 Dawson A, Trumper P, de Souza JO, Parker H, Jones MJ, Hales TG, Hunter WN. Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein. Iucrj. 6: 1014-1023. PMID 31709057 DOI: 10.1107/S205225251901114X  0.356
2019 Sharma KK, Hales TG, Rao VJ, NicDaeid N, McKenzie C. The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning. Forensic Toxicology. 37: 1-16. PMID 30636980 DOI: 10.1007/S11419-018-0454-5  0.308
2019 Davies P, Hales TG, Jensen AA, Peters JA. ZAC (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f83/2019.4  0.311
2019 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f72/2019.4  0.374
2019 Barnes NM, Hales TG, Lummis SCR, Niesler B, Peters JA. 5-HT3 receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f68/2019.4  0.508
2019 Smith M, Baptista-Hon D, Antonides L, McKenzie C, Daeid N, Hales T. Activation of the mu-opioid receptor by MT-45 and its synthetic and metabolic derivatives British Journal of Anaesthesia. 122: e51. DOI: 10.1016/J.Bja.2018.10.047  0.343
2019 Singleton S, Baptista-Hon D, Bull F, Hales T. Measuring the bias of morphine, oxycodone, and buprenorphine for G protein activation vs β-arrestin2 recruitment to the μ opioid receptor British Journal of Anaesthesia. 122: e48. DOI: 10.1016/J.Bja.2018.10.038  0.307
2018 Gottschald Chiodi C, Baptista-Hon DT, Hunter WN, Hales TG. Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA. The Journal of Biological Chemistry. PMID 30545943 DOI: 10.1074/Jbc.Ra118.006229  0.446
2018 Elajnaf T, Baptista-Hon DT, Hales TG. Potent Inactivation-Dependent Inhibition of Adult and Neonatal NaV1.5 Channels by Lidocaine and Levobupivacaine. Anesthesia and Analgesia. PMID 29958221 DOI: 10.1213/Ane.0000000000003597  0.319
2016 Baptista-Hon DT, Gulbinaite S, Hales TG. Loop G in the GABAA receptor α1 subunit influences gating efficacy. The Journal of Physiology. PMID 27981574 DOI: 10.1113/Jp273752  0.439
2016 Baptista-Hon DT, Krah A, Zachariae U, Hales TG. A role for loop G in the β1 strand in GABAA receptor activation. The Journal of Physiology. PMID 27195487 DOI: 10.1113/Jp272463  0.442
2015 House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Silvio Gutkind J, Hales TG, Lee NH. Voltage-gated Na(+) Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Scientific Reports. 5: 11541. PMID 26096612 DOI: 10.1038/Srep11541  0.691
2015 Morton RA, Baptista-Hon DT, Hales TG, Lovinger DM. Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors. British Journal of Pharmacology. 172: 4066-77. PMID 25989383 DOI: 10.1111/Bph.13197  0.788
2015 Vickery ON, Baptista-Hon DT, Seeliger D, Hales TG, Zachariae U. Investigating the Effect of Sodium and Voltage on δ-Opioid Receptors Biophysical Journal. 108: 414a. DOI: 10.1016/J.Bpj.2014.11.2272  0.38
2014 Baptista-Hon DT, Robertson FM, Robertson GB, Owen SJ, Rogers GW, Lydon EL, Lee NH, Hales TG. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. British Journal of Anaesthesia. 113: i39-i48. PMID 24852501 DOI: 10.1093/Bja/Aeu104  0.314
2013 Carland JE, Cooper MA, Livesey MR, Hales TG, Peters JA, Lambert JJ. Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor. The Journal of Biological Chemistry. 288: 31592-601. PMID 24030822 DOI: 10.1074/Jbc.M113.503300  0.502
2013 Baptista-Hon DT, Deeb TZ, Lambert JJ, Peters JA, Hales TG. The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals. The Journal of Biological Chemistry. 288: 21558-68. PMID 23740249 DOI: 10.1074/Jbc.M113.481689  0.719
2012 Othman NA, Gallacher M, Deeb TZ, Baptista-Hon DT, Perry DC, Hales TG. Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization. The Journal of Physiology. 590: 163-78. PMID 22083597 DOI: 10.1113/Jphysiol.2011.213249  0.729
2012 Baptista-Hon DT, Deeb TZ, Othman NA, Sharp D, Hales TG. The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine. British Journal of Pharmacology. 165: 693-704. PMID 21740409 DOI: 10.1111/J.1476-5381.2011.01582.X  0.755
2011 Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W. Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2. Molecular Pain. 7: 24. PMID 21486473 DOI: 10.1186/1744-8069-7-24  0.459
2011 Morton RA, Luo G, Davis MI, Hales TG, Lovinger DM. Fluorophore assisted light inactivation (FALI) of recombinant 5-HT₃A receptor constitutive internalization and function. Molecular and Cellular Neurosciences. 47: 79-92. PMID 21338684 DOI: 10.1016/J.Mcn.2011.02.007  0.743
2010 House CD, Vaske CJ, Schwartz AM, Obias V, Frank B, Luu T, Sarvazyan N, Irby R, Strausberg RL, Hales TG, Stuart JM, Lee NH. Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion. Cancer Research. 70: 6957-67. PMID 20651255 DOI: 10.1158/0008-5472.Can-10-1169  0.689
2010 Wu DF, Othman NA, Sharp D, Mahendra A, Deeb TZ, Hales TG. A conserved cysteine residue in the third transmembrane domain is essential for homomeric 5-HT3 receptor function. The Journal of Physiology. 588: 603-16. PMID 19933756 DOI: 10.1113/Jphysiol.2009.181719  0.761
2010 Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG, Lambert JJ. Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. The Journal of Physiology. 588: 587-96. PMID 19933751 DOI: 10.1113/Jphysiol.2009.183137  0.426
2010 House C, Vaske C, Schwartz A, Obias V, Sarvazyan N, Hales T, Stuart J, Lee N. Abstract 5292: Role of voltage-gated Na+ channels in the metastatic potential of colon cancer cells Cancer Research. 70: 5292-5292. DOI: 10.1158/1538-7445.Am10-5292  0.712
2009 Walwyn W, John S, Maga M, Evans CJ, Hales TG. Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons. Molecular Pharmacology. 76: 134-43. PMID 19357247 DOI: 10.1124/Mol.109.055913  0.487
2009 Deeb TZ, Sharp D, Hales TG. Direct subunit-dependent multimodal 5-hydroxytryptamine3 receptor antagonism by methadone. Molecular Pharmacology. 75: 908-17. PMID 19131665 DOI: 10.1124/Mol.108.053322  0.77
2009 Barnes NM, Hales TG, Lummis SC, Peters JA. The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology. 56: 273-84. PMID 18761359 DOI: 10.1016/J.Neuropharm.2008.08.003  0.569
2009 Morton RA, Luo G, Davis MI, Hales TG, Lovinger DM. Ethanol and trafficking of 5-HT3A receptors Alcoholism: Clinical and Experimental Research. 33. DOI: 10.1111/J.1530-0277.2009.00957.X  0.726
2008 Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ, Peters JA. Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor. The Journal of Biological Chemistry. 283: 19301-13. PMID 18474595 DOI: 10.1074/Jbc.M802406200  0.722
2008 Bollan KA, Baur R, Hales TG, Sigel E, Connolly CN. The promiscuous role of the epsilon subunit in GABAA receptor biogenesis. Molecular and Cellular Neurosciences. 37: 610-21. PMID 18206389 DOI: 10.1016/J.Mcn.2007.12.011  0.41
2008 Drisdel RC, Sharp D, Henderson T, Hales TG, Green WN. High affinity binding of epibatidine to serotonin type 3 receptors. The Journal of Biological Chemistry. 283: 9659-65. PMID 17702741 DOI: 10.1074/Jbc.M703672200  0.481
2007 Walwyn W, Evans CJ, Hales TG. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5092-104. PMID 17494695 DOI: 10.1523/Jneurosci.1157-07.2007  0.404
2007 Deeb TZ, Carland JE, Cooper MA, Livesey MR, Lambert JJ, Peters JA, Hales TG. Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor. The Journal of Biological Chemistry. 282: 6172-82. PMID 17200121 DOI: 10.1074/Jbc.M607698200  0.756
2007 McCartney MR, Deeb TZ, Henderson TN, Hales TG. Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating. Molecular Pharmacology. 71: 539-48. PMID 17090706 DOI: 10.1124/Mol.106.028597  0.751
2006 Peters JA, Carland JE, Cooper MA, Livesey MR, Deeb TZ, Hales TG, Lambert JJ. Novel structural determinants of single-channel conductance in nicotinic acetylcholine and 5-hydroxytryptamine type-3 receptors. Biochemical Society Transactions. 34: 882-6. PMID 17052220 DOI: 10.1042/Bst0340882  0.761
2006 Hales TG, Deeb TZ, Tang H, Bollan KA, King DP, Johnson SJ, Connolly CN. An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits. The Journal of Biological Chemistry. 281: 17034-43. PMID 16627470 DOI: 10.1074/Jbc.M603599200  0.754
2006 Hales TG, Dunlop JI, Deeb TZ, Carland JE, Kelley SP, Lambert JJ, Peters JA. Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 281: 8062-71. PMID 16407231 DOI: 10.1074/Jbc.M513222200  0.728
2005 Wagner DA, Goldschen-Ohm MP, Hales TG, Jones MV. Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10462-8. PMID 16280584 DOI: 10.1523/Jneurosci.1658-05.2005  0.531
2005 Peters JA, Hales TG, Lambert JJ. Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor. Trends in Pharmacological Sciences. 26: 587-94. PMID 16194573 DOI: 10.1016/J.Tips.2005.09.011  0.483
2005 Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Molecular Pharmacology. 68: 1688-98. PMID 16135785 DOI: 10.1124/Mol.105.014829  0.484
2005 Hales TG, Tang H, Bollan KA, Johnson SJ, King DP, McDonald NA, Cheng A, Connolly CN. The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors. Molecular and Cellular Neurosciences. 29: 120-7. PMID 15866052 DOI: 10.1016/J.Mcn.2005.01.002  0.411
2004 Charles AC, Hales TG. From inhibition to excitation: functional effects of interaction between opioid receptors. Life Sciences. 76: 479-85. PMID 15556161 DOI: 10.1016/J.Lfs.2004.09.012  0.404
2004 Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. Biochemical Society Transactions. 32: 547-52. PMID 15157181 DOI: 10.1042/Bst0320547  0.553
2003 Stewart A, Davies PA, Kirkness EF, Safa P, Hales TG. Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells. Neuropharmacology. 44: 214-23. PMID 12623220 DOI: 10.1016/S0028-3908(02)00376-3  0.505
2003 Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, Hales TG. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Molecular Pharmacology. 63: 89-95. PMID 12488540 DOI: 10.1124/Mol.63.1.89  0.441
2003 Davies PA, Wang W, Hales TG, Kirkness EF. A novel class of ligand-gated ion channel is activated by Zn2+. The Journal of Biological Chemistry. 278: 712-7. PMID 12381728 DOI: 10.1074/Jbc.M208814200  0.411
2003 Stewart A, Davies PA, Kirkness EF, Safa P, Hales TG. Introduction of the 5-HT 3B subunit alters the functional properties of 5-HT 3 receptors native to neuroblastoma cells Neuropharmacology. 44: 214-223. DOI: 10.1016/S0028-3908(02)00376-3  0.411
2002 Davies PA, McCartney MR, Wang W, Hales TG, Kirkness EF. Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat. Neuropharmacology. 43: 467-75. PMID 12367593 DOI: 10.1016/S0028-3908(02)00153-3  0.44
2002 Irnaten M, Walwyn WM, Wang J, Venkatesan P, Evans C, Chang KS, Andresen MC, Hales TG, Mendelowitz D. Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit. Anesthesiology. 97: 717-24. PMID 12218540 DOI: 10.1097/00000542-200209000-00027  0.401
2002 Davies PA, Kirkness EF, Hales TG. Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors. The Journal of Physiology. 537: 101-13. PMID 11711565 DOI: 10.1111/J.1469-7793.2001.0101K.X  0.484
2001 Safa P, Boulter J, Hales TG. Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cells. The Journal of Biological Chemistry. 276: 38727-37. PMID 11514547 DOI: 10.1074/Jbc.M103724200  0.333
2000 Hanna MC, Davies PA, Hales TG, Kirkness EF. Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents. Journal of Neurochemistry. 75: 240-7. PMID 10854267 DOI: 10.1046/J.1471-4159.2000.0750240.X  0.549
2000 Piros ET, Charles AC, Song L, Evans CJ, Hales TG. Cloned δ-opioid receptors in GH3 cells inhibit spontaneous Ca2+ oscillations and prolactin release through K(IR) channel activation Journal of Neurophysiology. 83: 2691-2698. PMID 10805669 DOI: 10.1152/Jn.2000.83.5.2691  0.377
2000 Davies PA, Hoffmann EB, Carlisle HJ, Tyndale RF, Hales TG. The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells. Neuropharmacology. 39: 611-20. PMID 10728882 DOI: 10.1016/S0028-3908(99)00163-X  0.461
1999 Tian J, Chau C, Hales TG, Kaufman DL. GABA(A) receptors mediate inhibition of T cell responses. Journal of Neuroimmunology. 96: 21-8. PMID 10227421 DOI: 10.1016/S0165-5728(98)00264-1  0.389
1999 Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF. The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 397: 359-63. PMID 9950429 DOI: 10.1038/16941  0.584
1998 Bronstein JM, Hales TG, Tyndale RF, Charles AC. A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors. Journal of Neurochemistry. 70: 483-91. PMID 9453541 DOI: 10.1046/J.1471-4159.1998.70020483.X  0.429
1997 Davies PA, Kirkness EF, Hales TG. Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells. British Journal of Pharmacology. 120: 899-909. PMID 9138697 DOI: 10.1038/Sj.Bjp.0700987  0.414
1997 Davies PA, Hanna MC, Hales TG, Kirkness EF. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature. 385: 820-3. PMID 9039914 DOI: 10.1038/385820A0  0.476
1996 Piros ET, Hales TG, Evans CJ. Functional analysis of cloned opioid receptors in transfected cell lines Neurochemical Research. 21: 1277-1285. PMID 8947917 DOI: 10.1007/Bf02532368  0.391
1995 Adodra S, Hales TG. Potentiation, activation and blockade of GABAA receptors of clonal murine hypothalamic GT1-7 neurones by propofol. British Journal of Pharmacology. 115: 953-60. PMID 7582526 DOI: 10.1111/J.1476-5381.1995.Tb15903.X  0.42
1994 Hales TG, Sanderson MJ, Charles AC. GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons. Neuroendocrinology. 59: 297-308. PMID 8159279 DOI: 10.1159/000126671  0.421
1994 Tyndale RF, Hales TG, Olsen RW, Tobin AJ. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5417-28. PMID 8083745 DOI: 10.1523/Jneurosci.14-09-05417.1994  0.452
1994 Hales T, Tyndale R. Few cell lines with GABAA mRNAs have functional receptors The Journal of Neuroscience. 14: 5429-5436. DOI: 10.1523/Jneurosci.14-09-05429.1994  0.442
1992 Hales TG, Lambert JJ. Modulation of GABAA and glycine receptors by chlormethiazole. European Journal of Pharmacology. 210: 239-46. PMID 1319334 DOI: 10.1016/0014-2999(92)90410-6  0.468
1992 Hales TG, Jones MV, Harrison NL. EVIDENCE FOR SUBUNIT DEPENDENT DIRECT ACTIVATION OF THE GABAA RECEPTOR BY ISOFLURANE Anesthesiology. 77: A698. DOI: 10.1097/00000542-199209001-00698  0.484
1992 Hales TG. DIRECT ACTIVATION OF GABAA RECEPTORS BY PROPOFOL MAY BE SUBUNIT SPECIFIC Anesthesiology. 77: A695. DOI: 10.1097/00000542-199209001-00695  0.381
1991 Hales TG, Lambert JJ. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. British Journal of Pharmacology. 104: 619-28. PMID 1665745 DOI: 10.1111/J.1476-5381.1991.Tb12479.X  0.442
1991 Hales TG, Lambert JJ. MODULATION OF THE GABAA RECEPTOR BY PROPOFOL Anesthesiology. 75: A587. DOI: 10.1097/00000542-199109001-00586  0.375
1990 Lambert JJ, Peters JA, Sturgess NC, Hales TG. Steroid modulation of the GABAA receptor complex: electrophysiological studies. Ciba Foundation Symposium. 153: 56-71; discussion 71. PMID 1963400 DOI: 10.1002/9780470513989.ch4  0.415
1989 Lambert JJ, Peters JA, Hales TG, Dempster J. The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques. British Journal of Pharmacology. 97: 27-40. PMID 2720311 DOI: 10.1111/J.1476-5381.1989.Tb11920.X  0.464
1988 Peters JA, Hales TG, Lambert JJ. Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells. European Journal of Pharmacology. 151: 491-5. PMID 2463926 DOI: 10.1016/0014-2999(88)90550-X  0.493
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