| Year |
Citation |
Score |
| 2023 |
Aow J, Huang TR, Goh YT, Sun AX, Thinakaran G, Koo EH. Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment. Cell Reports. 42: 112774. PMID 37450368 DOI: 10.1016/j.celrep.2023.112774 |
0.336 |
|
| 2023 |
Ulku I, Liebsch F, Akerman SC, Schulz JF, Kulic L, Hock C, Pietrzik C, Di Spiezio A, Thinakaran G, Saftig P, Multhaup G. Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis. Scientific Reports. 13: 2216. PMID 36750595 DOI: 10.1038/s41598-023-28846-z |
0.42 |
|
| 2022 |
Ponnusamy M, Wang S, Yuksel M, Hansen MT, Blazier DM, McMillan JD, Zhang X, Dammer EB, Collier L, Thinakaran G. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a Journal of Neurology. PMID 36059072 DOI: 10.1093/brain/awac318 |
0.319 |
|
| 2022 |
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, ... Thinakaran G, et al. BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Molecular Neurodegeneration. 17: 33. PMID 35526014 DOI: 10.1186/s13024-022-00535-x |
0.317 |
|
| 2022 |
Aow J, Huang TR, Thinakaran G, Koo EH. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells. Molecular Neurobiology. PMID 35266114 DOI: 10.1007/s12035-022-02733-6 |
0.415 |
|
| 2020 |
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, Krause SV, Freedman DJ, Bindokas VP, Kasthuri N, ... ... Thinakaran G, et al. Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell Reports. 30: 3520-3535.e7. PMID 32160554 DOI: 10.1016/J.Celrep.2020.02.026 |
0.331 |
|
| 2019 |
Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. Cell Reports. 27: 1345-1355.e6. PMID 31042463 DOI: 10.1016/J.Celrep.2019.03.087 |
0.5 |
|
| 2019 |
Zerweck J, Venkata BS, Pittman JM, Srivastava AK, Moore PC, Sachleben JR, Thinakaran G, Meredith SC. A versatile method for producing labeled or unlabeled Aβ55, Aβ40, and other β-amyloid family peptides. Protein Expression and Purification. PMID 31022450 DOI: 10.1016/J.Pep.2019.04.006 |
0.405 |
|
| 2019 |
Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. The Journal of Biological Chemistry. PMID 30692199 DOI: 10.1074/Jbc.Ra118.006379 |
0.522 |
|
| 2018 |
De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, ... ... Thinakaran G, et al. Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models. Brain Pathology (Zurich, Switzerland). PMID 30506549 DOI: 10.1111/Bpa.12687 |
0.504 |
|
| 2018 |
Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, Andrew RJ, Thinakaran G, Posse de Chaves E, Kar S. Endosomal-lysosomal Cholesterol Sequestration by U18666A Differentially Regulates APP Metabolism in Normal and APP Overexpressing Cells. Molecular and Cellular Biology. PMID 29530923 DOI: 10.1128/Mcb.00529-17 |
0.462 |
|
| 2018 |
Andrew RJ, Rossi PD, Guerbette T, Krause SV, Rice RC, Rathbun EM, Thinakaran G. P1-204: Deletion Of A Single Bin1 Allele Does Not Alter Amyloid Pathology In A Mouse Model Of Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.209 |
0.426 |
|
| 2018 |
Rossi PD, Andrew RJ, Musial TF, Krause SV, Buggia-Prevot V, Rice RC, Pytel P, Nicholson D, Thinakaran G. P1-202: Myelin Breakdown Leads To Bin1 Accumulation In Amyloid Deposits Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.207 |
0.358 |
|
| 2017 |
De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G. BIN1 localization is distinct from Tau tangles in Alzheimer's disease. Matters. 2017. PMID 29479533 |
0.351 |
|
| 2017 |
Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, ... ... Thinakaran G, et al. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078331 DOI: 10.1073/Pnas.1708568114 |
0.498 |
|
| 2017 |
Maulik M, Vergote D, Phukan G, Chung J, Thinakaran G, Kar S. The Effects of Extracellular Serum Concentration on APP Processing in Npc1-Deficient APP-Overexpressing N2a Cells. Molecular Neurobiology. PMID 29052144 DOI: 10.1007/S12035-017-0799-5 |
0.446 |
|
| 2016 |
De Rossi P, Buggia-Prévot V, Clayton BL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, ... ... Thinakaran G, et al. Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Molecular Neurodegeneration. 11: 59. PMID 27488240 DOI: 10.1186/S13024-016-0124-1 |
0.433 |
|
| 2016 |
Andrew RJ, Kellett KA, Thinakaran G, Hooper NM. A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis. The Journal of Biological Chemistry. PMID 27474742 DOI: 10.1074/Jbc.R116.746032 |
0.471 |
|
| 2016 |
Wang Y, MacDonald RG, Thinakaran G, Kar S. Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. Molecular Neurobiology. PMID 26993302 DOI: 10.1007/S12035-016-9849-7 |
0.336 |
|
| 2016 |
Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathologica. PMID 26993139 DOI: 10.1007/S00401-016-1558-9 |
0.505 |
|
| 2016 |
Deyts C, Thinakaran G, Parent AT. APP Receptor? To Be or Not To Be. Trends in Pharmacological Sciences. PMID 26837733 DOI: 10.1016/J.Tips.2016.01.005 |
0.398 |
|
| 2015 |
Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Scientific Reports. 5: 17042. PMID 26608390 DOI: 10.1038/Srep17042 |
0.465 |
|
| 2015 |
Buggia-Prévot V, Thinakaran G. Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 888-98. PMID 26126792 DOI: 10.1002/Bies.201500019 |
0.402 |
|
| 2015 |
Wang Y, Buggia-Prévot V, Zavorka ME, Bleackley RC, MacDonald RG, Thinakaran G, Kar S. Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability. Molecular and Cellular Biology. 35: 2368-84. PMID 25939386 DOI: 10.1128/Mcb.01338-14 |
0.407 |
|
| 2014 |
Marquer C, Laine J, Dauphinot L, Hanbouch L, Lemercier-Neuillet C, Pierrot N, Bossers K, Le M, Corlier F, Benstaali C, Saudou F, Thinakaran G, Cartier N, Octave JN, Duyckaerts C, et al. Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes. Molecular Neurodegeneration. 9: 60. PMID 25524049 DOI: 10.1186/1750-1326-9-60 |
0.414 |
|
| 2014 |
Wang Y, Thinakaran G, Kar S. Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology. Plos One. 9: e98057. PMID 24846272 DOI: 10.1371/Journal.Pone.0098057 |
0.443 |
|
| 2014 |
Buggia-Prévot V, Thinakaran G. Sorting the role of SORLA in Alzheimer's disease. Science Translational Medicine. 6: 223fs8. PMID 24523319 DOI: 10.1126/Scitranslmed.3008562 |
0.366 |
|
| 2014 |
Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Molecular Neurodegeneration. 9: 1. PMID 24386896 DOI: 10.1186/1750-1326-9-1 |
0.393 |
|
| 2014 |
Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S. Rheb GTPase regulates β-secretase levels and amyloid β generation. The Journal of Biological Chemistry. 289: 5799-808. PMID 24368770 DOI: 10.1074/Jbc.M113.532713 |
0.486 |
|
| 2013 |
Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, ... ... Thinakaran G, et al. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Reports. 5: 1552-63. PMID 24373286 DOI: 10.1016/J.Celrep.2013.12.006 |
0.404 |
|
| 2013 |
Udayar V, Buggia-Prévot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J, Simons M, Ries J, Puthenveedu MA, Hardy J, Thinakaran G, et al. A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production. Cell Reports. 5: 1536-51. PMID 24373285 DOI: 10.1016/J.Celrep.2013.12.005 |
0.466 |
|
| 2013 |
Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G. Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion. The Journal of Biological Chemistry. 288: 26955-66. PMID 23902769 DOI: 10.1074/Jbc.M113.473355 |
0.409 |
|
| 2013 |
Maulik M, Thinakaran G, Kar S. Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein. Plos One. 8: e54605. PMID 23382922 DOI: 10.1371/Journal.Pone.0054605 |
0.419 |
|
| 2013 |
Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Udayar V, Elie A, Lefkow M, Roseman J, Meckler X, Bhattacharyya S, George M, Waters J, Bindokas VP, Parent AT, Rajendran L, ... ... Thinakaran G, et al. Regulation of dynamic BACE1 trafficking in neurons Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O8 |
0.449 |
|
| 2013 |
Deyts C, Herrera S, Das S, Clutter M, Thinakaran G, Parent A. P1-102: Secretase-dependent APP-CTF accumulation influences differentially axodendritic development and associated signalling Alzheimer's & Dementia. 9: P188-P188. DOI: 10.1016/J.Jalz.2013.05.324 |
0.329 |
|
| 2012 |
Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R. Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs. Plos One. 7: e48551. PMID 23152781 DOI: 10.1371/Journal.Pone.0048551 |
0.521 |
|
| 2012 |
Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspectives in Medicine. 2: a006270. PMID 22553493 DOI: 10.1101/Cshperspect.A006270 |
0.506 |
|
| 2012 |
Deyts C, Vetrivel KS, Das S, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT. Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1714-29. PMID 22302812 DOI: 10.1523/Jneurosci.5433-11.2012 |
0.451 |
|
| 2012 |
Gong P, Roseman J, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Parent AT, Thinakaran G. Stringently regulated p23 expression is critical for coordinated movement in mice: implications for Alzheimer’s disease Molecular Neurodegeneration. 7: L2. DOI: 10.1186/1750-1326-7-S1-L2 |
0.443 |
|
| 2011 |
Gong P, Roseman J, Fernandez CG, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Parent AT, Thinakaran G. Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice. Molecular Neurodegeneration. 6: 87. PMID 22204304 DOI: 10.1186/1750-1326-6-87 |
0.391 |
|
| 2011 |
Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 26166-77. PMID 21642424 DOI: 10.1074/Jbc.M111.260471 |
0.431 |
|
| 2010 |
Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G. Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16160-9. PMID 21123562 DOI: 10.1523/Jneurosci.4436-10.2010 |
0.483 |
|
| 2010 |
Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. The Journal of Biological Chemistry. 285: 38042-52. PMID 20921220 DOI: 10.1074/Jbc.M110.132613 |
0.411 |
|
| 2010 |
Parent AT, Thinakaran G. Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function. International Journal of Alzheimer's Disease. 2010. PMID 20798900 DOI: 10.4061/2010/825918 |
0.515 |
|
| 2010 |
Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel KS, Thinakaran G, Vance JE, Kar S. Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains. Glia. 58: 1267-81. PMID 20607864 DOI: 10.1002/Glia.21001 |
0.469 |
|
| 2010 |
Vetrivel KS, Thinakaran G. Membrane rafts in Alzheimer's disease beta-amyloid production. Biochimica Et Biophysica Acta. 1801: 860-7. PMID 20303415 DOI: 10.1016/J.Bbalip.2010.03.007 |
0.509 |
|
| 2009 |
White AB, Givogri MI, Lopez-Rosas A, Cao H, van Breemen R, Thinakaran G, Bongarzone ER. Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6068-77. PMID 19439584 DOI: 10.1523/Jneurosci.5597-08.2009 |
0.383 |
|
| 2009 |
Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/Jbc.M808920200 |
0.491 |
|
| 2009 |
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, ... Thinakaran G, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/Jbc.M806380200 |
0.49 |
|
| 2009 |
Gandy S, Cirrito J, Steele J, Kim SH, Thinakaran G, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM. S4-04-06: Dimebon®: A Clinically Promising Drug for Alzheimer's Disease, Regulates Amyloid-Beta Metabolism in Cultured Cells, In Isolated Nerve Terminals, and In the Interstitial Fluid of the Living Rodent Brain Alzheimer's & Dementia. 5: e5-e5. DOI: 10.1016/J.Jalz.2009.07.133 |
0.384 |
|
| 2008 |
Vetrivel KS, Kodam A, Gong P, Chen Y, Parent AT, Kar S, Thinakaran G. Localization and regional distribution of p23/TMP21 in the brain. Neurobiology of Disease. 32: 37-49. PMID 18652896 DOI: 10.1016/J.Nbd.2008.06.012 |
0.432 |
|
| 2008 |
Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. The Journal of Biological Chemistry. 283: 29615-9. PMID 18650430 DOI: 10.1074/Jbc.R800019200 |
0.507 |
|
| 2008 |
Neet KE, Thinakaran G. Thematic minireview series on the molecular basis of Alzheimer disease. The Journal of Biological Chemistry. 283: 29613-4. PMID 18650429 DOI: 10.1074/Jbc.R800051200 |
0.409 |
|
| 2008 |
Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, ... Thinakaran G, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/Jbc.M801037200 |
0.403 |
|
| 2008 |
Barnes NY, Shi J, Yajima H, Thinakaran G, Parent AT. Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons. Journal of Neurochemistry. 104: 1637-48. PMID 17996025 DOI: 10.1111/J.1471-4159.2007.05102.X |
0.389 |
|
| 2008 |
Kodam A, Vetrivel KS, Thinakaran G, Kar S. Cellular distribution of γ-secretase subunit nicastrin in the developing and adult rat brains Neurobiology of Aging. 29: 724-738. PMID 17222950 DOI: 10.1016/J.Neurobiolaging.2006.12.005 |
0.331 |
|
| 2007 |
Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW. Biogenesis of gamma-secretase early in the secretory pathway. The Journal of Cell Biology. 179: 951-63. PMID 18056412 DOI: 10.1083/Jcb.200709012 |
0.506 |
|
| 2007 |
Cheng H, Vetrivel KS, Gong P, Meckler X, Parent A, Thinakaran G. Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts. Nature Clinical Practice. Neurology. 3: 374-82. PMID 17611486 DOI: 10.1038/Ncpneuro0549 |
0.503 |
|
| 2007 |
Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Molecular Neurodegeneration. 2: 4. PMID 17288597 DOI: 10.1186/1750-1326-2-4 |
0.506 |
|
| 2006 |
Thinakaran G, Sisodia SS. Presenilins and Alzheimer disease: the calcium conspiracy. Nature Neuroscience. 9: 1354-5. PMID 17066063 DOI: 10.1038/Nn1106-1354 |
0.319 |
|
| 2006 |
Vetrivel KS, Zhang YW, Xu H, Thinakaran G. Pathological and physiological functions of presenilins. Molecular Neurodegeneration. 1: 4. PMID 16930451 DOI: 10.1186/1750-1326-1-4 |
0.514 |
|
| 2006 |
Vetrivel KS, Thinakaran G. Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments. Neurology. 66: S69-73. PMID 16432149 DOI: 10.1212/01.Wnl.0000192107.17175.39 |
0.492 |
|
| 2005 |
Jutras I, Laplante A, Boulais J, Brunet S, Thinakaran G, Desjardins M. Gamma-secretase is a functional component of phagosomes. The Journal of Biological Chemistry. 280: 36310-7. PMID 16103123 DOI: 10.1074/Jbc.M504069200 |
0.372 |
|
| 2005 |
Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G. Spatial segregation of gamma-secretase and substrates in distinct membrane domains. The Journal of Biological Chemistry. 280: 25892-900. PMID 15886206 DOI: 10.1074/Jbc.M503570200 |
0.425 |
|
| 2005 |
Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. The Journal of Biological Chemistry. 280: 17020-6. PMID 15711015 DOI: 10.1074/Jbc.M409467200 |
0.435 |
|
| 2005 |
Parent AT, Barnes NY, Taniguchi Y, Thinakaran G, Sisodia SS. Presenilin attenuates receptor-mediated signaling and synaptic function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1540-9. PMID 15703408 DOI: 10.1523/Jneurosci.3850-04.2005 |
0.388 |
|
| 2004 |
Ito D, Walker JR, Thompson CS, Moroz I, Lin W, Veselits ML, Hakim AM, Fienberg AA, Thinakaran G. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties Molecular and Cellular Biology. 24: 9456-9469. PMID 15485913 DOI: 10.1128/Mcb.24.21.9456-9469.2004 |
0.328 |
|
| 2004 |
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. The Journal of Biological Chemistry. 279: 44945-54. PMID 15322084 DOI: 10.1074/Jbc.M407986200 |
0.445 |
|
| 2004 |
Thinakaran G, Parent AT. Identification of the role of presenilins beyond Alzheimer's disease. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 50: 411-8. PMID 15304238 DOI: 10.1016/J.Phrs.2003.12.026 |
0.504 |
|
| 2004 |
Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of Biological Chemistry. 279: 40560-6. PMID 15247291 DOI: 10.1074/Jbc.M404345200 |
0.302 |
|
| 2003 |
Thinakaran G, Bowen JW, Ito D, Leem JY, Veselits ML, Sato N. Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants. Methods in Molecular Biology (Clifton, N.J.). 232: 203-16. PMID 12840551 DOI: 10.1385/1-59259-394-1:203 |
0.413 |
|
| 2003 |
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 422: 438-41. PMID 12660785 DOI: 10.1038/Nature01506 |
0.45 |
|
| 2003 |
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. The Journal of Biological Chemistry. 278: 7850-4. PMID 12522139 DOI: 10.1074/Jbc.C200648200 |
0.415 |
|
| 2003 |
Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 3446-54. PMID 12435726 DOI: 10.1074/Jbc.M209065200 |
0.437 |
|
| 2002 |
Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546 |
0.468 |
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| 2002 |
Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G. Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. The Journal of Biological Chemistry. 277: 19236-40. PMID 11943765 DOI: 10.1074/Jbc.C200148200 |
0.432 |
|
| 2002 |
Kim SH, Creemers JW, Chu S, Thinakaran G, Sisodia SS. Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides. The Journal of Biological Chemistry. 277: 1872-7. PMID 11709554 DOI: 10.1074/Jbc.M108739200 |
0.325 |
|
| 2001 |
Thinakaran G. Metabolism of presenilins. Journal of Molecular Neuroscience. 17: 183-192. PMID 11816791 DOI: 10.1385/Jmn:17:2:183 |
0.456 |
|
| 2001 |
Kim SH, Leem JY, Lah JJ, Slunt HH, Levey AI, Thinakaran G, Sisodia SS. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. The Journal of Biological Chemistry. 276: 43343-50. PMID 11564743 DOI: 10.1074/Jbc.M108245200 |
0.449 |
|
| 2000 |
Thinakaran G, Doan A. Determining the transmembrane topology of the presenilins. Methods in Molecular Medicine. 32: 283-96. PMID 21318526 DOI: 10.1385/1-59259-195-7:283 |
0.43 |
|
| 2000 |
Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Thinakaran G, Lynn DG, Meredith SC, Sisodia SS. Familial British dementia: expression and metabolism of BRI. Annals of the New York Academy of Sciences. 920: 93-9. PMID 11193182 DOI: 10.1111/J.1749-6632.2000.Tb06909.X |
0.39 |
|
| 2000 |
Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nature Cell Biology. 2: 863-70. PMID 11146649 DOI: 10.1038/35046500 |
0.442 |
|
| 2000 |
Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2 |
0.492 |
|
| 2000 |
Kim SH, Lah JJ, Thinakaran G, Levey A, Sisodia SS. Subcellular localization of presenilins: association with a unique membrane pool in cultured cells. Neurobiology of Disease. 7: 99-117. PMID 10783294 DOI: 10.1006/Nbdi.1999.0280 |
0.342 |
|
| 2000 |
Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. The Journal of Biological Chemistry. 275: 17136-42. PMID 10748144 DOI: 10.1074/Jbc.M909624199 |
0.482 |
|
| 2000 |
Sisodia SS, Martys SKJ, Wang R, Sklar J, Berechid B, Nye J, Thinakaran G. Molecular Mechanisms of Familial Alzheimer's Disease Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A129A |
0.344 |
|
| 2000 |
Leem JY, Saura C, Tomita T, Iwatsubo T, Thinakaran G. Structural domain requirements for presenilin endoproteolysis and Aβ42 overproduction Neurobiology of Aging. 21: 261. DOI: 10.1016/S0197-4580(00)83129-2 |
0.324 |
|
| 2000 |
Sato N, Kim S, Veselits M, Chu S, Sisodia SS, Thinakaran G. Influence of PS and FAD-linked PS variants on the mammalian unfolded protein response Neurobiology of Aging. 21: 259. DOI: 10.1016/S0197-4580(00)83117-6 |
0.354 |
|
| 2000 |
Thinakaran G. Cell biology of APP and PS1 Neurobiology of Aging. 21: 76. DOI: 10.1016/S0197-4580(00)82563-4 |
0.36 |
|
| 1999 |
Berechid BE, Thinakaran G, Wong PC, Sisodia SS, Nye JS. Lack of requirement for presenilin1 in Notch1 signaling. Current Biology : Cb. 9: 1493-6. PMID 10607593 DOI: 10.1016/S0960-9822(00)80121-9 |
0.313 |
|
| 1999 |
Thinakaran G. The role of presenilins in Alzheimer’s disease Journal of Clinical Investigation. 104: 1321-1327. PMID 10562290 DOI: 10.1172/Jci8728 |
0.48 |
|
| 1999 |
Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Lynn DG, Thinakaran G, Meredith SC, Sisodia SS. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nature Neuroscience. 2: 984-8. PMID 10526337 DOI: 10.1038/14783 |
0.359 |
|
| 1999 |
Sisodia SS, Kim SH, Thinakaran G. Function and dysfunction of the presenilins. American Journal of Human Genetics. 65: 7-12. PMID 10364510 DOI: 10.1086/302475 |
0.471 |
|
| 1999 |
Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing Journal of Biological Chemistry. 274: 13818-13823. PMID 10318786 DOI: 10.1074/Jbc.274.20.13818 |
0.447 |
|
| 1999 |
Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 96: 742-7. PMID 9892704 DOI: 10.1073/Pnas.96.2.742 |
0.488 |
|
| 1998 |
Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Advances in Experimental Medicine and Biology. 446: 145-59. PMID 10079842 DOI: 10.1007/978-1-4615-4869-0_9 |
0.431 |
|
| 1998 |
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6 |
0.416 |
|
| 1998 |
Buxbaum JD, Thinakaran G, Koliatsos V, O'Callahan J, Slunt HH, Price DL, Sisodia SS. Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9629-37. PMID 9822724 DOI: 10.1523/Jneurosci.18-23-09629.1998 |
0.478 |
|
| 1998 |
McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Research. 804: 45-51. PMID 9729270 DOI: 10.1016/S0006-8993(98)00653-2 |
0.495 |
|
| 1998 |
Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiology of Disease. 4: 438-53. PMID 9666482 DOI: 10.1006/Nbdi.1998.0171 |
0.467 |
|
| 1998 |
Lyckman AW, Confaloni AM, Thinakaran G, Sisodia SS, Moya KL. Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. The Journal of Biological Chemistry. 273: 11100-6. PMID 9556595 DOI: 10.1074/Jbc.273.18.11100 |
0.492 |
|
| 1998 |
Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, et al. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Medicine. 4: 447-51. PMID 9546791 DOI: 10.1038/Nm0498-447 |
0.487 |
|
| 1997 |
von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiology of Aging. 18: 661-9. PMID 9461064 DOI: 10.1016/S0197-4580(97)00151-6 |
0.351 |
|
| 1997 |
Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, Borchelt DR, Sisodia SS. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. The Journal of Biological Chemistry. 272: 28415-22. PMID 9353300 DOI: 10.1074/Jbc.272.45.28415 |
0.431 |
|
| 1997 |
Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR. Endoproteolytic processing and stabilization of wild-type and mutant presenilin. The Journal of Biological Chemistry. 272: 24536-41. PMID 9305918 DOI: 10.1074/Jbc.272.39.24536 |
0.376 |
|
| 1997 |
Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Medicine. 3: 756-60. PMID 9212102 DOI: 10.1038/Nm0797-756 |
0.453 |
|
| 1997 |
Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen FE, Carlson GA, Prusiner SB. Identification of candidate proteins binding to prion protein. Neurobiology of Disease. 3: 339-55. PMID 9173930 DOI: 10.1006/Nbdi.2002.0484 |
0.406 |
|
| 1997 |
Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 5090-4. PMID 9144195 DOI: 10.1073/Pnas.94.10.5090 |
0.347 |
|
| 1997 |
Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 3748-52. PMID 9108049 DOI: 10.1073/Pnas.94.8.3748 |
0.388 |
|
| 1997 |
Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878 DOI: 10.1074/Jbc.272.3.1896 |
0.353 |
|
| 1997 |
Saporito-irwin SM, Thinakaran G, Ruffini L, Sisodia SS, Nostrand WEV. Amyloid $sZ-protein stimulates parallel increases in cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells Amyloid. 4: 54-60. DOI: 10.3109/13506129708995270 |
0.47 |
|
| 1996 |
Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 93: 14940-4. PMID 8962160 DOI: 10.1073/Pnas.93.25.14940 |
0.389 |
|
| 1996 |
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9 |
0.4 |
|
| 1996 |
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5 |
0.508 |
|
| 1996 |
Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7513-25. PMID 8922407 DOI: 10.1523/Jneurosci.16-23-07513.1996 |
0.398 |
|
| 1996 |
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17: 181-90. PMID 8755489 DOI: 10.1016/S0896-6273(00)80291-3 |
0.422 |
|
| 1996 |
Sisodia SS, Thinakaran G, Slunt HH, Kitt CA, Von Koch CS, Reed RR, Zheng H, Price DL. Studies on the metabolism and biological function of APLP2. Annals of the New York Academy of Sciences. 777: 77-81. PMID 8624130 DOI: 10.1111/J.1749-6632.1996.Tb34404.X |
0.418 |
|
| 1996 |
Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. The Journal of Biological Chemistry. 271: 9390-7. PMID 8621605 DOI: 10.1074/Jbc.271.16.9390 |
0.469 |
|
| 1996 |
Thinakaran G, Doan A, Lee M, Slunt H, Savage M, Greenberg B, Wang R, Price D, Sisodia S. 443 Characterization of presenilin 1 (PS1) with mutations linked to familial Alzheimer's disease: Metabolism, topology and influence on Aβ generation Neurobiology of Aging. 17: S110. DOI: 10.1016/S0197-4580(96)80445-3 |
0.41 |
|
| 1996 |
Walters J, Hung A, Thinakaran G, Sisodia S, Selkoe D, Haassl C. 388 Phosphorylation of ß-amyloid precursor protein at two distinct cellular locations Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80390-3 |
0.425 |
|
| 1995 |
Lo AC, Thinakaran G, Slunt HH, Sisodia SS. Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain. The Journal of Biological Chemistry. 270: 12641-5. PMID 7759513 DOI: 10.1074/Jbc.270.21.12641 |
0.499 |
|
| 1995 |
Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM. A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. The Biochemical Journal. 310: 95-9. PMID 7646477 DOI: 10.1042/Bj3100095 |
0.378 |
|
| 1995 |
Thinakaran G, Slunt HH, Sisodia SS. Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2. The Journal of Biological Chemistry. 270: 16522-5. PMID 7622456 DOI: 10.1074/Jbc.270.28.16522 |
0.497 |
|
| 1995 |
Thinakaran G, Kitt CA, Roskams AJ, Slunt HH, Masliah E, von Koch C, Ginsberg SD, Ronnett GV, Reed RR, Price DL. Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 6314-26. PMID 7472397 DOI: 10.1523/Jneurosci.15-10-06314.1995 |
0.363 |
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