| Year |
Citation |
Score |
| 2023 |
Berman AY, Wieczorek M, Aher A, Olinares PDB, Chait BT, Kapoor TM. A nucleotide binding-independent role for γ-tubulin in microtubule capping and cell division. The Journal of Cell Biology. 222. PMID 36695784 DOI: 10.1083/jcb.202204102 |
0.335 |
|
| 2022 |
Renda F, Miles C, Tikhonenko I, Fisher R, Carlini L, Kapoor TM, Mogilner A, Khodjakov A. Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells. Current Biology : Cb. PMID 35108523 DOI: 10.1016/j.cub.2022.01.013 |
0.354 |
|
| 2021 |
Santarossa CC, Mickolajczyk KJ, Steinman JB, Urnavicius L, Chen N, Hirata Y, Fukase Y, Coudray N, Ekiert DC, Bhabha G, Kapoor TM. Targeting allostery in the Dynein motor domain with small molecule inhibitors. Cell Chemical Biology. PMID 34015309 DOI: 10.1016/j.chembiol.2021.04.024 |
0.309 |
|
| 2020 |
Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng ET, Vatandaslar H, Chait BT, Kapoor TM, Darst SA, Campbell EA. Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell. PMID 32783916 DOI: 10.1016/J.Cell.2020.07.033 |
0.414 |
|
| 2020 |
Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng ET, Vatandaslar H, Chait B, Kapoor T, Darst SA, Campbell EA. Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex. Biorxiv : the Preprint Server For Biology. PMID 32676607 DOI: 10.1101/2020.07.08.194084 |
0.417 |
|
| 2019 |
Pamula MC, Carlini L, Forth S, Verma P, Suresh S, Legant WR, Khodjakov A, Betzig E, Kapoor TM. High-resolution imaging reveals how the spindle midzone impacts chromosome movement. The Journal of Cell Biology. PMID 31248912 DOI: 10.1083/Jcb.201904169 |
0.319 |
|
| 2018 |
Chen Z, Suzuki H, Kobayashi Y, Wang AC, DiMaio F, Kawashima SA, Walz T, Kapoor TM. Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis. Cell. PMID 30318141 DOI: 10.1016/J.Cell.2018.09.015 |
0.364 |
|
| 2018 |
Shimamoto Y, Kapoor TM. Analyzing the micromechanics of the cell division apparatus. Methods in Cell Biology. 145: 173-190. PMID 29957203 DOI: 10.1016/bs.mcb.2018.03.022 |
0.362 |
|
| 2017 |
Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, ... ... Kapoor TM, et al. Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action. Elife. 6. PMID 28524820 DOI: 10.7554/Elife.25174 |
0.534 |
|
| 2017 |
Kapoor TM. Metaphase Spindle Assembly. Biology. 6. PMID 28165376 DOI: 10.3390/biology6010008 |
0.337 |
|
| 2017 |
Forth S, Shimamoto Y, Kapoor T. Measuring Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules Biophysical Journal. 112: 45a. DOI: 10.1016/J.Bpj.2016.11.281 |
0.421 |
|
| 2016 |
Kawashima SA, Chen Z, Aoi Y, Patgiri A, Kobayashi Y, Nurse P, Kapoor TM. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. PMID 27667686 DOI: 10.1016/J.Cell.2016.08.070 |
0.402 |
|
| 2015 |
See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK. Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. Acs Chemical Biology. PMID 26555042 DOI: 10.1021/Acschembio.5B00895 |
0.569 |
|
| 2015 |
Shimamoto Y, Forth S, Kapoor TM. Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules. Developmental Cell. 34: 669-81. PMID 26418296 DOI: 10.1016/J.Devcel.2015.08.017 |
0.323 |
|
| 2014 |
Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A. Direct kinetochore-spindle pole connections are not required for chromosome segregation. The Journal of Cell Biology. 206: 231-43. PMID 25023516 DOI: 10.1083/Jcb.201401090 |
0.439 |
|
| 2014 |
Shimamoto Y, Forth S, Kapoor T. 1P189 Examining mitotic functions of bipolar kinesin Eg5 in a reconstituted minimal microtubule network(12. Cell biology,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54: S172. DOI: 10.2142/Biophys.54.S172_3 |
0.342 |
|
| 2013 |
Yi J, Wu X, Chung AH, Chen JK, Kapoor TM, Hammer JA. Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage. The Journal of Cell Biology. 202: 779-92. PMID 23979719 DOI: 10.1083/Jcb.201301004 |
0.491 |
|
| 2013 |
Subramanian R, Ti SC, Tan L, Darst SA, Kapoor TM. Marking and measuring single microtubules by PRC1 and kinesin-4. Cell. 154: 377-90. PMID 23870126 DOI: 10.1016/J.Cell.2013.06.021 |
0.378 |
|
| 2013 |
Liu X, Kapoor TM, Chen JK, Huse M. Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proceedings of the National Academy of Sciences of the United States of America. 110: 11976-81. PMID 23818610 DOI: 10.1073/Pnas.1306180110 |
0.466 |
|
| 2013 |
Foley EA, Kapoor TM. Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nature Reviews. Molecular Cell Biology. 14: 25-37. PMID 23258294 DOI: 10.1038/nrm3494 |
0.324 |
|
| 2013 |
Forth S, Hsia K, Kapoor TM. Asymmetric Force Response Reveals Mechanical Role in Spindle Protein Localization Biophysical Journal. 104: 551a. DOI: 10.1016/J.Bpj.2012.11.3053 |
0.343 |
|
| 2012 |
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 484: 125-9. PMID 22425997 DOI: 10.1038/Nature10936 |
0.567 |
|
| 2011 |
Weinger JS, Qiu M, Yang G, Kapoor TM. A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding. Current Biology : Cb. 21: 154-60. PMID 21236672 DOI: 10.1016/J.Cub.2010.12.038 |
0.335 |
|
| 2010 |
Subramanian R, Wilson-Kubalek EM, Arthur CP, Bick MJ, Campbell EA, Darst SA, Milligan RA, Kapoor TM. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell. 142: 433-43. PMID 20691902 DOI: 10.1016/J.Cell.2010.07.012 |
0.351 |
|
| 2010 |
Weinger JS, Kapoor TM. Single Molecule Analysis of the Mitotic Kinesin Eg5 Biophysical Journal. 98: 165a. DOI: 10.1016/J.Bpj.2009.12.891 |
0.308 |
|
| 2010 |
Subramanian R, Wilson-Kubalek EM, Campbell EA, Bick MJ, Drast SA, Milligan RA, Kapoor TM. Structural Basis for Microtubule Binding by the Anti-Parallel Microtubule Crosslinker PRC1 (Protein Regulator of Cytokinesis-1) Biophysical Journal. 98: 362a. DOI: 10.1016/J.Bpj.2009.12.1953 |
0.304 |
|
| 2009 |
Houghtaling BR, Yang G, Matov A, Danuser G, Kapoor TM. Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle. Proceedings of the National Academy of Sciences of the United States of America. 106: 15338-43. PMID 19706424 DOI: 10.1073/Pnas.0902317106 |
0.36 |
|
| 2009 |
Subramanian R, Kapoor T. Meiotic spindle self-organization: one plus one equals only one. Current Biology : Cb. 19: R290-2. PMID 19368872 DOI: 10.1016/J.Cub.2009.02.032 |
0.352 |
|
| 2008 |
Kapitein LC, Kwok BH, Weinger JS, Schmidt CF, Kapoor TM, Peterman EJ. Microtubule cross-linking triggers the directional motility of kinesin-5. The Journal of Cell Biology. 182: 421-8. PMID 18678707 DOI: 10.1083/Jcb.200801145 |
0.319 |
|
| 2008 |
Schreiber SL, Kapoor TM, Wess G. Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3 Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 1-1205. DOI: 10.1002/9783527619375 |
0.341 |
|
| 2007 |
Yang G, Houghtaling BR, Gaetz J, Liu JZ, Danuser G, Kapoor TM. Architectural dynamics of the meiotic spindle revealed by single-fluorophore imaging. Nature Cell Biology. 9: 1233-42. PMID 17934454 DOI: 10.1038/Ncb1643 |
0.36 |
|
| 2007 |
Brennan IM, Peters U, Kapoor TM, Straight AF. Polo-like kinase controls vertebrate spindle elongation and cytokinesis. Plos One. 2: e409. PMID 17476331 DOI: 10.1371/Journal.Pone.0000409 |
0.636 |
|
| 2007 |
Kwok BH, Kapoor TM. Microtubule flux: drivers wanted. Current Opinion in Cell Biology. 19: 36-42. PMID 17174541 DOI: 10.1016/j.ceb.2006.12.003 |
0.352 |
|
| 2006 |
Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM. Probing cell-division phenotype space and Polo-like kinase function using small molecules. Nature Chemical Biology. 2: 618-26. PMID 17028580 DOI: 10.1038/Nchembio826 |
0.379 |
|
| 2006 |
Kwok BH, Kapitein LC, Kim JH, Peterman EJ, Schmidt CF, Kapoor TM. Allosteric inhibition of kinesin-5 modulates its processive directional motility. Nature Chemical Biology. 2: 480-5. PMID 16892050 DOI: 10.1038/Nchembio812 |
0.348 |
|
| 2006 |
Lampson MA, Kapoor TM. Unraveling cell division mechanisms with small-molecule inhibitors. Nature Chemical Biology. 2: 19-27. PMID 16408087 DOI: 10.1038/Nchembio757 |
0.323 |
|
| 2005 |
Khodjakov A, Kapoor T. Microtubule flux: what is it good for? Current Biology : Cb. 15: R966-8. PMID 16332529 DOI: 10.1016/J.Cub.2005.11.017 |
0.437 |
|
| 2005 |
Kapitein LC, Peterman EJ, Kwok BH, Kim JH, Kapoor TM, Schmidt CF. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature. 435: 114-8. PMID 15875026 DOI: 10.1038/Nature03503 |
0.377 |
|
| 2005 |
Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM. Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. Molecular Biology of the Cell. 16: 3064-76. PMID 15788560 DOI: 10.1091/Mbc.E05-02-0174 |
0.757 |
|
| 2005 |
Cochran JC, Gatial JE, Kapoor TM, Gilbert SP. Monastrol inhibition of the mitotic kinesin Eg5. The Journal of Biological Chemistry. 280: 12658-67. PMID 15665380 DOI: 10.1074/Jbc.M413140200 |
0.305 |
|
| 2004 |
Kwok BH, Yang JG, Kapoor TM. The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5. Current Biology : Cb. 14: 1783-8. PMID 15458652 DOI: 10.1016/J.Cub.2004.09.052 |
0.359 |
|
| 2004 |
Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM. Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Molecular Biology of the Cell. 15: 5603-15. PMID 15385629 DOI: 10.1091/Mbc.E04-05-0440 |
0.698 |
|
| 2004 |
Gaetz J, Kapoor TM. Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles. The Journal of Cell Biology. 166: 465-71. PMID 15314063 DOI: 10.1083/jcb.200404015 |
0.362 |
|
| 2004 |
Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP. Mechanistic analysis of the mitotic kinesin Eg5. The Journal of Biological Chemistry. 279: 38861-70. PMID 15247293 DOI: 10.1074/Jbc.M404203200 |
0.647 |
|
| 2004 |
Peters U, Kapoor TM. New probes for microtubule dynamics. Chemistry & Biology. 11: 14-6. PMID 15112989 DOI: 10.1016/J.Chembiol.2004.01.003 |
0.331 |
|
| 2004 |
Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM. Correcting improper chromosome-spindle attachments during cell division. Nature Cell Biology. 6: 232-7. PMID 14767480 DOI: 10.1038/Ncb1102 |
0.333 |
|
| 2003 |
Garrett S, Kapoor TM. Microtubule assembly: catastrophe factors to the rescue. Current Biology : Cb. 13: R810-2. PMID 14561423 DOI: 10.1016/j.cub.2003.09.052 |
0.308 |
|
| 2003 |
Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang G, Kapoor TM, Salmon ED. Determining the position of the cell division plane. Nature. 424: 1074-8. PMID 12904818 DOI: 10.1038/Nature01860 |
0.698 |
|
| 2003 |
Hotha S, Yarrow JC, Yang JG, Garrett S, Renduchintala KV, Mayer TU, Kapoor TM. HR22C16: a potent small-molecule probe for the dynamics of cell division. Angewandte Chemie (International Ed. in English). 42: 2379-82. PMID 12783501 DOI: 10.1002/Anie.200351173 |
0.702 |
|
| 2002 |
Garrett S, Auer K, Compton DA, Kapoor TM. hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Current Biology : Cb. 12: 2055-9. PMID 12477396 DOI: 10.1016/S0960-9822(02)01277-0 |
0.393 |
|
| 2002 |
Maliga Z, Kapoor TM, Mitchison TJ. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chemistry & Biology. 9: 989-96. PMID 12323373 DOI: 10.1016/S1074-5521(02)00212-0 |
0.738 |
|
| 2001 |
Kapoor TM, Mitchison TJ. Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix. The Journal of Cell Biology. 154: 1125-33. PMID 11564753 DOI: 10.1083/Jcb.200106011 |
0.55 |
|
| 2000 |
Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC. The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core. Bioorganic & Medicinal Chemistry. 8: 2219-27. PMID 11026535 DOI: 10.1016/S0968-0896(00)00155-3 |
0.383 |
|
| 2000 |
Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. The Journal of Cell Biology. 150: 975-88. PMID 10973989 DOI: 10.1083/Jcb.150.5.975 |
0.717 |
|
| 2000 |
Rotella DP, Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small-molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen Chemtracts. 13: 256-258. |
0.642 |
|
| 1999 |
Maddox P, Desai A, Salmon ED, Mitchison TJ, Oogema K, Kapoor T, Matsumoto B, Inoué S. Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles. The Biological Bulletin. 197: 263-5. PMID 10573847 DOI: 10.2307/1542641 |
0.595 |
|
| 1999 |
Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (New York, N.Y.). 286: 971-4. PMID 10542155 DOI: 10.1126/Science.286.5441.971 |
0.759 |
|
| 1999 |
Ferrer M, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Wiley DC, Harrison SC. Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nature Structural Biology. 6: 953-60. PMID 10504731 DOI: 10.1038/13324 |
0.389 |
|
| 1999 |
Kapoor TM, Mitchison TJ. Allele-specific activators and inhibitors for kinesin. Proceedings of the National Academy of Sciences of the United States of America. 96: 9106-11. PMID 10430903 DOI: 10.1073/Pnas.96.16.9106 |
0.533 |
|
| 1998 |
Morken JP, Kapoor TM, Feng S, Shirai F, Schreiber SL. Exploring the leucine-proline binding pocket of the Src SH3 domain using structure-based, split-pool synthesis and affinity-based selection Journal of the American Chemical Society. 120: 30-36. DOI: 10.1021/Ja972729M |
0.579 |
|
| 1998 |
Kapoor TM, Andreotti AH, Schreiber SL. Exploring the specificity pockets of two homologous SH3 domain using structure-based, split-pool synthesis and affinity-based selection Journal of the American Chemical Society. 120: 23-29. DOI: 10.1021/ja972728u |
0.615 |
|
| 1996 |
Feng S, Kapoor TM, Shirai F, Combs AP, Schreiber SL. Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chemistry & Biology. 3: 661-70. PMID 8807900 DOI: 10.1016/S1074-5521(96)90134-9 |
0.365 |
|
| 1996 |
Combs AP, Kapoor TM, Feng S, Chen JK, Daudé-Snow LF, Schreiber SL. Protein structure-based combinatorial chemistry: Discovery of non-peptide binding elements to Src SH3 domain Journal of the American Chemical Society. 118: 287-288. DOI: 10.1021/Ja953750V |
0.526 |
|
| 1994 |
Pruschy MN, Spencer DM, Kapoor TM, Miyake H, Crabtree GR, Schreiber SL. Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. Chemistry & Biology. 1: 163-72. PMID 9383386 DOI: 10.1016/1074-5521(94)90006-X |
0.374 |
|
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