Mary-Ellen Harper - Publications

Affiliations: 
University of Ottawa, Ottawa, ON, Canada 
Area:
Biochemistry, Cell Biology

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Whytock KL, Pino MF, Sun Y, Yu G, De Carvalho FG, Yeo RX, Vega RB, Gaganvir P, Divoux A, Kapoor N, Yi F, Cornnell HH, Patten DA, Harper ME, Gardell SJ, et al. Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity. American Journal of Physiology. Endocrinology and Metabolism. PMID 37584609 DOI: 10.1152/ajpendo.00143.2023  0.382
2022 Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SA, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, ... ... Harper ME, et al. Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. Ebiomedicine. 104192. PMID 35965199 DOI: 10.1016/j.ebiom.2022.104192  0.701
2022 Pileggi CA, Hooks BG, McPherson R, Dent RRM, Harper ME. Targeting skeletal muscle mitochondrial health in obesity. Clinical Science (London, England : 1979). 136: 1081-1110. PMID 35892309 DOI: 10.1042/CS20210506  0.34
2021 Daussin FN, Cuillerier A, Touron J, Bensaid S, Melo B, Al Rewashdy A, Vasam G, Menzies KJ, Harper ME, Heyman E, Burelle Y. Dietary Cocoa Flavanols Enhance Mitochondrial Function in Skeletal Muscle and Modify Whole-Body Metabolism in Healthy Mice. Nutrients. 13. PMID 34684467 DOI: 10.3390/nu13103466  0.393
2021 Dumont AA, Dumont L, Zhou D, Giguère H, Pileggi C, Harper ME, Blondin DP, Scott MS, Auger-Messier M. Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21544. PMID 33819356 DOI: 10.1096/fj.202002293RR  0.335
2021 Liaghati A, Pileggi CA, Parmar G, Patten DA, Hadzimustafic N, Cuillerier A, Menzies KJ, Burelle Y, Harper ME. Regulates Skeletal Muscle Mitochondrial Structure and Autophagy. Frontiers in Physiology. 12: 604210. PMID 33762963 DOI: 10.3389/fphys.2021.604210  0.413
2021 Pileggi CA, Parmar G, Harper ME. The lifecycle of skeletal muscle mitochondria in obesity. Obesity Reviews : An Official Journal of the International Association For the Study of Obesity. PMID 33442950 DOI: 10.1111/obr.13164  0.359
2020 Kennedy L, Sandhu JK, Harper ME, Cuperlovic-Culf M. Role of Glutathione in Cancer: From Mechanisms to Therapies. Biomolecules. 10. PMID 33050144 DOI: 10.3390/biom10101429  0.647
2020 Boardman NT, Migally B, Pileggi C, Parmar GS, Xuan JY, Menzies K, Harper ME. Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165982. PMID 33002579 DOI: 10.1016/j.bbadis.2020.165982  0.34
2020 Patten DA, McGuirk S, Anilkumar U, Antoun G, Gandhi K, Parmar G, Iqbal MA, Wong J, Richardson RB, St-Pierre J, Slack RS, Harper ME. Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production. Biochimica Et Biophysica Acta. Molecular Cell Research. 118854. PMID 32926942 DOI: 10.1016/J.Bbamcr.2020.118854  0.479
2020 Grapov D, Fiehn O, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Keim NL, Hunter GR, Fernandez JR, Garvey WT, Hoppel CL, Harper ME, Newman JW, Adams SH. Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women. Physiological Reports. 8: e14547. PMID 32869956 DOI: 10.14814/Phy2.14547  0.337
2020 Nikpay M, Lau P, Soubeyrand S, Whytock KL, Beehler K, Pileggi C, Ghosh S, Harper ME, Dent R, McPherson R. rs679482 Associates with Weight Loss Success in Response to an Intensively Supervised Outpatient Program. Diabetes. PMID 32527767 DOI: 10.2337/Db20-0219  0.306
2020 Anilkumar U, Khacho M, Cuillerier A, Harris R, Patten DA, Bilen M, Iqbal MA, Guo DY, Trudeau LE, Park DS, Harper ME, Burelle Y, Slack RS. MCL-1 maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions. Cell Death & Disease. 11: 321. PMID 32371858 DOI: 10.1038/S41419-020-2498-9  0.405
2020 Patten D, Harper ME, Boardman N. Harnessing the protective role of OPA1 in diabetic cardiomyopathy. Acta Physiologica (Oxford, England). e13466. PMID 32175678 DOI: 10.1111/Apha.13466  0.384
2019 McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME. Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901150R. PMID 31581846 DOI: 10.1096/Fj.201901150R  0.515
2019 Villanueva M, Michie C, Parent S, Kanaan GN, Rafatian G, Kanda P, Ye B, Liang W, Harper ME, Davis DR. Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction. Theranostics. 9: 5720-5730. PMID 31534514 DOI: 10.7150/Thno.36639  0.302
2019 Grapov D, Fiehn O, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Hoppel CL, Harper ME, Adams SH. Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention. American Journal of Physiology. Endocrinology and Metabolism. PMID 31526287 DOI: 10.1152/Ajpendo.00091.2019  0.359
2019 Han CY, Patten DA, Lee SG, Parks RJ, Chan DW, Harper ME, Tsang BK. p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer. Molecular Carcinogenesis. PMID 31486135 DOI: 10.1002/Mc.23106  0.338
2019 Patten DA, Ouellet M, Allan DS, Germain M, Baird SD, Harper ME, Richardson RB. Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801483RR. PMID 31112400 DOI: 10.1096/Fj.201801483Rr  0.434
2019 Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, Tong Q, Krystkowiak I, Bondy-Chorney E, Davey NE, Krogan N, Downey M, Harper ME. SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Molecular Metabolism. PMID 31060926 DOI: 10.1016/J.Molmet.2019.04.008  0.416
2019 Valsesia A, Wang QP, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, ... ... Harper ME, et al. Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Nature Communications. 10: 540. PMID 30710084 DOI: 10.1038/S41467-019-08492-8  0.35
2018 Han CY, Patten DA, Richardson RB, Harper ME, Tsang BK. Tumor metabolism regulating chemosensitivity in ovarian cancer. Genes & Cancer. 9: 155-175. PMID 30603053 DOI: 10.18632/Genesandcancer.176  0.335
2018 Kanaan GN, Patten DA, Redpath CJ, Harper ME. Atrial Fibrillation Is Associated With Impaired Atrial Mitochondrial Energetics and Supercomplex Formation in Adults With Type 2 Diabetes. Canadian Journal of Diabetes. PMID 30146472 DOI: 10.1016/J.Jcjd.2018.05.007  0.347
2018 Salloum Z, Lehoux EA, Harper ME, Catelas I. EFFECTS OF COBALT AND CHROMIUM IONS ON OXIDATIVE STRESS AND ENERGY METABOLISM IN MACROPHAGES IN VITRO. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 30144138 DOI: 10.1002/Jor.24130  0.422
2018 Rajkumar A, Liaghati A, Chan J, Lamothe G, Dent R, Doucet É, Rabasa-Lhoret R, Prud'homme D, Harper ME, Tesson F. ACSL5 Genotype Influence On Fatty Acid Metabolism: A Cellular, Tissue, And Whole-Body Study. Metabolism: Clinical and Experimental. PMID 29605434 DOI: 10.1016/J.Metabol.2018.03.019  0.31
2017 Kanaan GN, Ichim B, Gharibeh L, Maharsy W, Patten DA, Xuan JY, Reunov A, Marshall P, Veinot J, Menzies K, Nemer M, Harper ME. Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies. Redox Biology. 14: 509-521. PMID 29101900 DOI: 10.1016/J.Redox.2017.10.019  0.432
2017 Kanaan GN, Harper ME. Cellular redox dysfunction in the development of cardiovascular diseases. Biochimica Et Biophysica Acta. PMID 28778485 DOI: 10.1016/J.Bbagen.2017.07.027  0.38
2016 Blondin DP, Daoud A, Taylor T, Tingelstad HC, Bézaire V, Richard D, Carpentier AC, Taylor AW, Harper ME, Aguer C, Haman F. Four-week cold acclimation in adult humans shifts uncoupling thermogenesis from skeletal muscles to BAT. The Journal of Physiology. PMID 28025824 DOI: 10.1113/Jp273395  0.391
2016 Aguer C, Piccolo BD, Fiehn O, Adams SH, Harper ME. A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27871066 DOI: 10.1096/Fj.201600914R  0.347
2016 McMurray F, Patten DA, Harper ME. Reactive Oxygen Species and Oxidative Stress in Obesity-Recent Findings and Empirical Approaches. Obesity (Silver Spring, Md.). 24: 2301-2310. PMID 27804267 DOI: 10.1002/Oby.21654  0.416
2016 Sparks LM, Redman LM, Conley KE, Harper ME, Yi F, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Shook C, Cornnell HH, Ravussin E, Smith SR. EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS. The Journal of Clinical Endocrinology and Metabolism. jc20163211. PMID 27778643 DOI: 10.1210/Jc.2016-3211  0.435
2016 Zhang J, Light AR, Hoppel CL, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Hughen RW, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Harper ME, et al. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. PMID 27730694 DOI: 10.1113/Ep086019  0.305
2016 Sparks LM, Redman LM, Conley KE, Harper ME, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Yi F, Shook C, Cornnell HH, Ravussin E, Smith SR. DIFFERENCES IN MITOCHONDRIAL COUPLING REVEAL A NOVEL SIGNATURE OF MITOHORMESIS IN MUSCLE OF HEALTHY INDIVIDUALS. The Journal of Clinical Endocrinology and Metabolism. jc20162742. PMID 27710240 DOI: 10.1210/Jc.2016-2742  0.384
2016 Rajkumar A, Lamothe G, Bolongo P, Harper ME, Adamo K, Doucet É, Rabasa-Lhoret R, Prud'homme D, Tesson F. Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity. Bmc Medical Genetics. 17: 56. PMID 27515448 DOI: 10.1186/S12881-016-0320-4  0.301
2016 Scott K, Benkhalti Jandu M, Calvert ND, Paquette M, Zhen L, Harper ME, Al-Dirbashi OY, Renaud JE. KATP CHANNEL DEFICIENCY IN MOUSE FDB CAUSES AN IMPAIRMENT OF ENERGY METABOLISM DURING FATIGUE. American Journal of Physiology. Cell Physiology. ajpcell.00137.2015. PMID 27488667 DOI: 10.1152/Ajpcell.00137.2015  0.378
2016 Richardson RB, Harper ME. Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy. Oncotarget. PMID 26894978 DOI: 10.18632/Oncotarget.7412  0.361
2016 Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SA, Baetz K. A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction. Scientific Reports. 6: 19332. PMID 26757638 DOI: 10.1038/Srep19332  0.351
2015 Beauchamp B, Harper ME. In utero Undernutrition Programs Skeletal and Cardiac Muscle Metabolism. Frontiers in Physiology. 6: 401. PMID 26779032 DOI: 10.3389/Fphys.2015.00401  0.428
2015 Antoun G, McMurray F, Thrush AB, Patten DA, Peixoto AC, Slack RS, McPherson R, Dent R, Harper ME. Erratum to: Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals. Diabetologia. PMID 26610932 DOI: 10.1007/s00125-015-3821-3  0.312
2015 Vanstone JR, Smith AM, McBride S, Naas T, Holcik M, Antoun G, Harper ME, Michaud J, Sell E, Chakraborty P, Tetreault M, Majewski J, Baird S, Boycott KM, et al. DNM1L-related mitochondrial fission defect presenting as refractory epilepsy. European Journal of Human Genetics : Ejhg. PMID 26604000 DOI: 10.1038/Ejhg.2015.243  0.427
2015 Antoun G, McBride S, Vanstone JR, Naas T, Michaud J, Redpath S, McMillan HJ, Brophy J, Daoud H, Chakraborty P, Dyment D, Holcik M, Harper ME, Lines MA. Detailed Biochemical and Bioenergetic Characterization of FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion. Jimd Reports. PMID 26404457 DOI: 10.1007/8904_2015_491  0.376
2015 Antoun G, McMurray F, Thrush AB, Patten DA, Peixoto AC, Slack RS, McPherson R, Dent R, Harper ME. Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals. Diabetologia. 58: 2861-6. PMID 26404066 DOI: 10.1007/S00125-015-3772-8  0.394
2015 Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME. Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Bioscience Reports. 35. PMID 26182362 DOI: 10.1042/Bsr20150007  0.424
2015 Karunakaran D, Thrush AB, Nguyen MA, Richards L, Geoffrion M, Singaravelu R, Ramphos E, Shangari P, Ouimet M, Pezacki JP, Moore KJ, Perisic L, Maegdefessel L, Hedin U, Harper ME, et al. Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and is Enhanced by Anti-miR33 in Atherosclerosis. Circulation Research. PMID 26002865 DOI: 10.1161/Circresaha.117.305624  0.315
2015 Beauchamp B, Ghosh S, Dysart MW, Kanaan GN, Chu A, Blais A, Rajamanickam K, Tsai EC, Patti ME, Harper ME. Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice. International Journal of Obesity (2005). 39: 702-11. PMID 25091727 DOI: 10.1038/Ijo.2014.120  0.425
2014 Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The Embo Journal. 33: 2676-91. PMID 25298396 DOI: 10.15252/Embj.201488349  0.441
2014 Thrush AB, Zhang R, Chen W, Seifert EL, Quizi JK, McPherson R, Dent R, Harper ME. Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans. The Journal of Clinical Endocrinology and Metabolism. 99: 4223-30. PMID 25148230 DOI: 10.1210/Jc.2014-1726  0.499
2014 Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, et al. KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. Plos One. 9: e103402. PMID 25072914 DOI: 10.1371/Journal.Pone.0103402  0.363
2014 Mailloux RJ, Xuan JY, McBride S, Maharsy W, Thorn S, Holterman CE, Kennedy CR, Rippstein P, deKemp R, da Silva J, Nemer M, Lou M, Harper ME. Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions. The Journal of Biological Chemistry. 289: 14812-28. PMID 24727547 DOI: 10.1074/Jbc.M114.550574  0.493
2014 Khacho M, Tarabay M, Patten D, Khacho P, MacLaurin JG, Guadagno J, Bergeron R, Cregan SP, Harper ME, Park DS, Slack RS. Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nature Communications. 5: 3550. PMID 24686499 DOI: 10.1038/Ncomms4550  0.476
2014 Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, Cron GO, Harper ME, Stintzi A, McBurney MW. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 1306-16. PMID 24297700 DOI: 10.1096/Fj.13-243568  0.389
2013 Mailloux RJ, McBride SL, Harper ME. Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. Trends in Biochemical Sciences. 38: 592-602. PMID 24120033 DOI: 10.1016/J.Tibs.2013.09.001  0.421
2013 Aguer C, Fiehn O, Seifert EL, Bézaire V, Meissen JK, Daniels A, Scott K, Renaud JM, Padilla M, Bickel DR, Dysart M, Adams SH, Harper ME. Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4213-25. PMID 23825224 DOI: 10.1096/Fj.13-234302  0.324
2013 Thrush AB, Dent R, McPherson R, Harper ME. Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity. The Febs Journal. 280: 5015-29. PMID 23786211 DOI: 10.1111/Febs.12399  0.385
2013 Adjeitey CN, Mailloux RJ, Dekemp RA, Harper ME. Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production. American Journal of Physiology. Endocrinology and Metabolism. 305: E405-15. PMID 23757405 DOI: 10.1152/Ajpendo.00057.2013  0.459
2013 Aguer C, Pasqua M, Thrush AB, Moffat C, McBurney M, Jardine K, Zhang R, Beauchamp B, Dent R, McPherson R, Harper ME. Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. Biochimica Et Biophysica Acta. 1832: 1624-33. PMID 23685312 DOI: 10.1016/J.Bbadis.2013.05.008  0.404
2013 Harasym AC, Thrush AB, Harper ME, Wright DC, Chan CB. Enhanced glucose homeostasis in BHE/cdb rats with mutated ATP synthase. Mitochondrion. 13: 320-9. PMID 23597782 DOI: 10.1016/J.Mito.2013.04.006  0.323
2013 Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metabolism. 17: 210-24. PMID 23395168 DOI: 10.1016/J.Cmet.2013.01.004  0.408
2013 Mailloux RJ, Xuan JY, Beauchamp B, Jui L, Lou M, Harper ME. Glutaredoxin-2 is required to control proton leak through uncoupling protein-3. The Journal of Biological Chemistry. 288: 8365-79. PMID 23335511 DOI: 10.1074/Jbc.M112.442905  0.49
2013 Thrush AB, Antoun G, Boushel R, Doucet É, Imbeault P, McPherson R, Dent R, Harper M. Investigating The Metabolic Basis for Weight loss Variability in Obese Humans Canadian Journal of Diabetes. 37: S241. DOI: 10.1016/J.Jcjd.2013.03.151  0.329
2012 Aguer C, Harper ME. Skeletal muscle mitochondrial energetics in obesity and type 2 diabetes mellitus: endocrine aspects. Best Practice & Research. Clinical Endocrinology & Metabolism. 26: 805-19. PMID 23168281 DOI: 10.1016/J.Beem.2012.06.001  0.461
2012 Mailloux RJ, Fu A, Robson-Doucette C, Allister EM, Wheeler MB, Screaton R, Harper ME. Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 287: 39673-85. PMID 23035124 DOI: 10.1074/Jbc.M112.393538  0.394
2012 Seifert EL, Bastianelli M, Aguer C, Moffat C, Estey C, Koch LG, Britton SL, Harper ME. Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. Journal of Applied Physiology (Bethesda, Md. : 1985). 113: 1624-34. PMID 22995392 DOI: 10.1152/Japplphysiol.01475.2011  0.359
2012 Siegel MP, Wilbur T, Mathis M, Shankland EG, Trieu A, Harper ME, Marcinek DJ. Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mechanisms of Ageing and Development. 133: 620-8. PMID 22935551 DOI: 10.1016/J.Mad.2012.08.002  0.414
2012 Mailloux RJ, Harper ME. Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins. Trends in Endocrinology and Metabolism: Tem. 23: 451-8. PMID 22591987 DOI: 10.1016/J.Tem.2012.04.004  0.443
2012 Estey C, Seifert EL, Aguer C, Moffat C, Harper ME. Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response. Experimental Gerontology. 47: 361-71. PMID 22406134 DOI: 10.1016/J.Exger.2012.02.008  0.457
2012 Seifert EL, Caron AZ, Morin K, Coulombe J, He XH, Jardine K, Dewar-Darch D, Boekelheide K, Harper ME, McBurney MW. SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 555-66. PMID 22006156 DOI: 10.1096/Fj.11-193979  0.342
2012 Mailloux RJ, Adjeitey CN, Xuan JY, Harper ME. Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 363-75. PMID 21940996 DOI: 10.1096/Fj.11-189639  0.495
2012 Zhou X, Gomez-Smith M, Qin Z, Duquette PM, Cardenas-Blanco A, Rai PS, Harper ME, Tsai EC, Anisman H, Chen HH. Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism. Cellular and Molecular Life Sciences : Cmls. 69: 819-28. PMID 21874351 DOI: 10.1007/S00018-011-0794-3  0.419
2012 Aguer C, Gambarotta D, Mailloux RJ, Moffat C, Dent R, McPherson R, Harper M. Correction: Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells Plos One. 7. DOI: 10.1371/annotation/eb51f7a7-a8fd-45a3-9df0-e6080c47fe06  0.37
2012 Kashemsant N, Bucurescu S, Fatehi-Hassanabad Z, Harper ME, Chan CB. Impairment of proinsulin processing in β-cells exposed to saturated free fatty acid is dependent on uncoupling protein-2 expression Canadian Journal of Diabetes. 36: 228-236. DOI: 10.1016/J.Jcjd.2012.06.007  0.39
2011 Aguer C, Gambarotta D, Mailloux RJ, Moffat C, Dent R, McPherson R, Harper ME. Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells. Plos One. 6: e28536. PMID 22194845 DOI: 10.1371/Journal.Pone.0028536  0.426
2011 Mailloux RJ, Harper ME. Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radical Biology & Medicine. 51: 1106-15. PMID 21762777 DOI: 10.1016/J.Freeradbiomed.2011.06.022  0.419
2011 Mailloux RJ, Dumouchel T, Aguer C, deKemp R, Beanlands R, Harper ME. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. The Biochemical Journal. 437: 301-11. PMID 21554247 DOI: 10.1042/Bj20110571  0.506
2011 Mailloux RJ, Seifert EL, Bouillaud F, Aguer C, Collins S, Harper ME. Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. The Journal of Biological Chemistry. 286: 21865-75. PMID 21515686 DOI: 10.1074/Jbc.M111.240242  0.465
2011 Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, Fernandez-Rodriguez J, Laakso M, Nilsson T, Peng XR, Harper ME, et al. The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes. 60: 427-35. PMID 21270254 DOI: 10.2337/Db10-0409  0.424
2010 Ghosh S, Dent R, Harper ME, Gorman SA, Stuart JS, McPherson R. Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity. Bmc Medical Genomics. 3: 56. PMID 21122113 DOI: 10.1186/1755-8794-3-56  0.32
2010 Mailloux RJ, Adjeitey CN, Harper ME. Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. Plos One. 5: e13289. PMID 20967268 DOI: 10.1371/Journal.Pone.0013289  0.353
2010 Scimè A, Soleimani VD, Bentzinger CF, Gillespie MA, Le Grand F, Grenier G, Bevilacqua L, Harper ME, Rudnicki MA. Oxidative status of muscle is determined by p107 regulation of PGC-1alpha. The Journal of Cell Biology. 190: 651-62. PMID 20713602 DOI: 10.1083/Jcb.201005076  0.434
2010 Seifert EL, Fiehn O, Bezaire V, Bickel DR, Wohlgemuth G, Adams SH, Harper ME. Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria. Plos One. 5: e9834. PMID 20352092 DOI: 10.1371/Journal.Pone.0009834  0.339
2010 Mailloux RJ, Harper ME. Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2495-506. PMID 20228249 DOI: 10.1096/Fj.09-151803  0.416
2010 Bevilacqua L, Seifert EL, Estey C, Gerrits MF, Harper ME. Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice. Biochimica Et Biophysica Acta. 1797: 1389-97. PMID 20206124 DOI: 10.1016/J.Bbabio.2010.02.018  0.501
2010 Seifert EL, Estey C, Xuan JY, Harper ME. Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. The Journal of Biological Chemistry. 285: 5748-58. PMID 20032466 DOI: 10.1074/Jbc.M109.026203  0.338
2010 Scimè A, Soleimani VD, Bentzinger CF, Gillespie MA, Grand FL, Grenier G, Bevilacqua L, Harper M, Rudnicki MA. Oxidative status of muscle is determined by p107 regulation of PGC-1a The Journal of General Physiology. 136. DOI: 10.1085/Jgp1364Oia3  0.332
2009 Holloway GP, Jain SS, Bezaire V, Han XX, Glatz JF, Luiken JJ, Harper ME, Bonen A. FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R960-7. PMID 19625692 DOI: 10.1152/Ajpregu.91021.2008  0.418
2009 Estey C, Seifert EL, Harper M. Mitochondrial uncoupling and remodelling during caloric restriction: Implications for oxidative stress and aging The Faseb Journal. 23. DOI: 10.20381/Ruor-12563  0.394
2008 Costford SR, Chaudhry SN, Crawford SA, Salkhordeh M, Harper ME. Long-term high-fat feeding induces greater fat storage in mice lacking UCP3. American Journal of Physiology. Endocrinology and Metabolism. 295: E1018-24. PMID 18713955 DOI: 10.1152/Ajpendo.00779.2007  0.434
2008 Seifert EL, Bézaire V, Estey C, Harper ME. Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. The Journal of Biological Chemistry. 283: 25124-31. PMID 18628202 DOI: 10.1074/Jbc.M803871200  0.482
2008 Harper ME, Green K, Brand MD. The efficiency of cellular energy transduction and its implications for obesity. Annual Review of Nutrition. 28: 13-33. PMID 18407744 DOI: 10.1146/Annurev.Nutr.28.061807.155357  0.394
2008 Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J, Evans M, Harper ME, McBurney MW. SirT1 regulates energy metabolism and response to caloric restriction in mice. Plos One. 3: e1759. PMID 18335035 DOI: 10.1371/Journal.Pone.0001759  0.432
2008 Harper ME, Seifert EL. Thyroid hormone effects on mitochondrial energetics. Thyroid : Official Journal of the American Thyroid Association. 18: 145-56. PMID 18279015 DOI: 10.1089/Thy.2007.0250  0.378
2008 Saleh MC, Fatehi-Hassanabad Z, Wang R, Nino-Fong R, Wadowska DW, Wright GM, Harper ME, Chan CB. Mutated ATP synthase induces oxidative stress and impaired insulin secretion in β-cells of female BHE/cdb rats Diabetes/Metabolism Research and Reviews. 24: 392-403. PMID 18273840 DOI: 10.1002/Dmrr.819  0.337
2007 Costford S, Gowing A, Harper ME. Mitochondrial uncoupling as a target in the treatment of obesity. Current Opinion in Clinical Nutrition and Metabolic Care. 10: 671-8. PMID 18089946 DOI: 10.1097/Mco.0B013E3282F0Dbe4  0.418
2007 Costford SR, Seifert EL, Bézaire V, F Gerrits M, Bevilacqua L, Gowing A, Harper ME. The energetic implications of uncoupling protein-3 in skeletal muscle. Applied Physiology, Nutrition, and Metabolism = Physiologie AppliquéE, Nutrition Et MéTabolisme. 32: 884-94. PMID 18059613 DOI: 10.1139/H07-063  0.376
2007 Costford SR, Kavaslar N, Ahituv N, Chaudhry SN, Schackwitz WS, Dent R, Pennacchio LA, McPherson R, Harper ME. Gain-of-function R225W mutation in human AMPKγ3 causing increased glycogen and decreased triglyceride in skeletal muscle Plos One. 2. PMID 17878938 DOI: 10.1371/Journal.Pone.0000903  0.365
2007 Adamo KB, Dent R, Langefeld CD, Cox M, Williams K, Carrick KM, Stuart JS, Sundseth SS, Harper ME, McPherson R, Tesson F. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity (Silver Spring, Md.). 15: 1068-75. PMID 17495181 DOI: 10.1038/Oby.2007.630  0.321
2007 Bézaire V, Seifert EL, Harper ME. Uncoupling protein-3: clues in an ongoing mitochondrial mystery. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 312-24. PMID 17202247 DOI: 10.1096/Fj.06-6966Rev  0.426
2007 Seifert EL, Bezaire V, Harper M. Role of uncoupling protein‐3 in fatty acid oxidation in skeletal muscle mitochondria The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A667  0.397
2006 Chan CB, Harper ME. Uncoupling proteins: Role in insulin resistance and insulin insufficiency Current Diabetes Reviews. 2: 271-283. PMID 18220632 DOI: 10.2174/157339906777950660  0.436
2006 Newell MK, Villalobos-Menuey E, Schweitzer SC, Harper ME, Camley RE. Cellular metabolism as a basis for immune privilege. Journal of Immune Based Therapies and Vaccines. 4: 1. PMID 16545119 DOI: 10.1186/1476-8518-4-1  0.332
2006 Costford SR, Chaudhry SN, Salkhordeh M, Harper ME. Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. American Journal of Physiology. Endocrinology and Metabolism. 290: E1304-12. PMID 16434555 DOI: 10.1152/Ajpendo.00401.2005  0.453
2006 Harper ME, Patrick J, Himms-Hagen J. Altered brown adipose tissue and Na,K pump activities during diet-induced obesity and weight loss in rats. Obesity Research. 1: 106-17. PMID 16350567 DOI: 10.1002/J.1550-8528.1993.Tb00599.X  0.352
2005 Scimè A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, Harper ME, Rudnicki MA. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metabolism. 2: 283-95. PMID 16271529 DOI: 10.1016/J.Cmet.2005.10.002  0.325
2005 MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB, Harper ME. Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes. 54: 2343-50. PMID 16046300 DOI: 10.2337/Diabetes.54.8.2343  0.469
2005 Sandhu JK, Sodja C, McRae K, Li Y, Rippstein P, Wei YH, Lach B, Lee F, Bucurescu S, Harper ME, Sikorska M. Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation. The Biochemical Journal. 391: 191-202. PMID 15969653 DOI: 10.1042/Bj20050272  0.45
2005 Rusyniak DE, Tandy SL, Hekmatyar SK, Mills E, Smith DJ, Bansal N, MacLellan D, Harper ME, Sprague JE. The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysis. The Journal of Pharmacology and Experimental Therapeutics. 313: 629-39. PMID 15644431 DOI: 10.1124/Jpet.104.079236  0.411
2005 Ramsey JJ, Harper ME, Humble SJ, Koomson EK, Ram JJ, Bevilacqua L, Hagopian K. Influence of mitochondrial membrane fatty acid composition on proton leak and H2O2 production in liver. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 140: 99-108. PMID 15621515 DOI: 10.1016/j.cbpc.2004.09.016  0.307
2004 Riachi M, Himms-Hagen J, Harper ME. Percent relative cumulative frequency analysis in indirect calorimetry: application to studies of transgenic mice. Canadian Journal of Physiology and Pharmacology. 82: 1075-83. PMID 15644949 DOI: 10.1139/Y04-117  0.366
2004 Harper ME, Gerrits MF. Mitochondrial uncoupling proteins as potential targets for pharmacological agents. Current Opinion in Pharmacology. 4: 603-7. PMID 15525551 DOI: 10.1016/J.Coph.2004.06.006  0.436
2004 Doucet E, Pomerleau M, Harper ME. Fasting and postprandial total ghrelin remain unchanged after short-term energy restriction. The Journal of Clinical Endocrinology and Metabolism. 89: 1727-32. PMID 15070937 DOI: 10.1210/Jc.2003-031459  0.311
2004 Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. American Journal of Physiology. Endocrinology and Metabolism. 286: E852-61. PMID 14736705 DOI: 10.1152/Ajpendo.00367.2003  0.321
2003 Liu X, Rossmeisl M, McClaine J, Riachi M, Harper ME, Kozak LP. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. The Journal of Clinical Investigation. 111: 399-407. PMID 12569166 DOI: 10.1172/JCI15737  0.333
2002 Harper ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio M, George A, Bartholomew R, Carlo D, Shaikh A, Kupperman J, Newell EW, Bespalov IA, Wallace SS, Liu Y, et al. Characterization of a novel metabolic strategy used by drug-resistant tumor cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1550-7. PMID 12374777 DOI: 10.1096/Fj.02-0541Com  0.331
2002 Harper ME, Dent R, Monemdjou S, Bézaire V, Van Wyck L, Wells G, Kavaslar GN, Gauthier A, Tesson F, McPherson R. Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes. 51: 2459-66. PMID 12145158 DOI: 10.2337/Diabetes.51.8.2459  0.77
2002 Argyropoulos G, Harper ME. Uncoupling proteins and thermoregulation. Journal of Applied Physiology (Bethesda, Md. : 1985). 92: 2187-98. PMID 11960973 DOI: 10.1152/Japplphysiol.00994.2001  0.463
2001 Harper ME, Dent RM, Bezaire V, Antoniou A, Gauthier A, Monemdjou S, McPherson R. UCP3 and its putative function: consistencies and controversies. Biochemical Society Transactions. 29: 768-73. PMID 11709072 DOI: 10.1042/Bst0290768  0.806
2001 Bézaire V, Hofmann W, Kramer JK, Kozak LP, Harper ME. Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. American Journal of Physiology. Endocrinology and Metabolism. 281: E975-82. PMID 11595653 DOI: 10.1152/Ajpendo.2001.281.5.E975  0.531
2001 Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nature Medicine. 7: 1128-32. PMID 11590436 DOI: 10.1038/Nm1001-1128  0.427
2001 Himms-Hagen J, Harper ME. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Experimental Biology and Medicine (Maywood, N.J.). 226: 78-84. PMID 11446442 DOI: 10.1177/153537020122600204  0.374
2001 Moore GBT, Himms-Hagen J, Harper M, Clapham JC. Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA. Biochemical and Biophysical Research Communications. 283: 785-790. PMID 11350053 DOI: 10.1006/Bbrc.2001.4848  0.489
2001 Hofmann WE, Liu X, Bearden CM, Harper M, Kozak LP. Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice. Journal of Biological Chemistry. 276: 12460-12465. PMID 11279075 DOI: 10.1074/Jbc.M100466200  0.423
2001 Lal SB, Ramsey JJ, Monemdjou S, Weindruch R, Harper ME. Effects of caloric restriction on skeletal muscle mitochondrial proton leak in aging rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: B116-22. PMID 11253148 DOI: 10.1093/Gerona/56.3.B116  0.758
2001 Harper M, Himms-Hagen J. Mitochondrial efficiency: lessons learned from transgenic mice. Biochimica Et Biophysica Acta. 1504: 159-172. PMID 11239492 DOI: 10.1016/S0005-2728(00)00244-9  0.417
2000 Monemdjou S, Hofmann WE, Kozak LP, Harper ME. Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice. American Journal of Physiology. Endocrinology and Metabolism. 279: E941-6. PMID 11001779 DOI: 10.1152/Ajpendo.2000.279.4.E941  0.799
2000 Kozak LP, Harper ME. Mitochondrial uncoupling proteins in energy expenditure Annual Review of Nutrition. 20: 339-363. PMID 10940338 DOI: 10.1146/Annurev.Nutr.20.1.339  0.471
2000 Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, Everett C, Kozak LP, Li C, Deng C, Harper ME, Reitman ML. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. The Journal of Biological Chemistry. 275: 16251-7. PMID 10748195 DOI: 10.1074/Jbc.M910177199  0.792
1999 Newell MK, Harper ME, Fortner K, Desbarats J, Russo A, Huber SA. Does the oxidative/glycolytic ratio determine proliferation or death in immune recognition? Annals of the New York Academy of Sciences. 887: 77-82. PMID 10668465 DOI: 10.1111/J.1749-6632.1999.Tb07923.X  0.323
1999 Monemdjou S, Kozak LP, Harper ME. Mitochondrial proton leak in brown adipose tissue mitochondria of Ucp1-deficient mice is GDP insensitive. The American Journal of Physiology. 276: E1073-82. PMID 10362620 DOI: 10.1152/Ajpendo.1999.276.6.E1073  0.801
1998 Harper ME, Monemdjou S, Ramsey JJ, Weindruch R. Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. American Journal of Physiology. Endocrinology and Metabolism. 275: E197-E206. PMID 29585194 DOI: 10.1152/ajpendo.1998.275.2.E197  0.794
1998 Harper ME, Monemdjou S, Ramsey JJ, Weindruch R. Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. The American Journal of Physiology. 275: E197-206. PMID 9688619 DOI: 10.1152/Ajpendo.1998.275.2.E197  0.794
1997 Enerbäck S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature. 387: 90-4. PMID 9139827 DOI: 10.1038/387090A0  0.504
1995 Harper ME, Brand MD. Use of top-down elasticity analysis to identify sites of thyroid hormone-induced thermogenesis. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 208: 228-37. PMID 7878061 DOI: 10.3181/00379727-208-43852B  0.378
1995 Harper ME, Brand MD. Hyperthyroidism stimulates mitochondrial proton leak and ATP turnover in rat hepatocytes but does not change the overall kinetics of substrate oxidation reactions. Canadian Journal of Physiology and Pharmacology. 72: 899-908. PMID 7834578 DOI: 10.1139/Y94-127  0.444
1995 Korzeniewski B, Harper ME, Brand MD. Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin. Biochimica Et Biophysica Acta. 1229: 315-22. PMID 7748883 DOI: 10.1016/0005-2728(95)00008-7  0.332
1993 Harper ME, Ballantyne JS, Leach M, Brand MD. Effects of thyroid hormones on oxidative phosphorylation. Biochemical Society Transactions. 785-92. PMID 8224511 DOI: 10.1042/Bst0210785  0.34
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