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Antonina I. Roll-Mecak, Ph.D. - Publications

Affiliations: 
2002 Rockefeller University, New York, NY, United States 
Area:
General Biophysics, Molecular Biology
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mahalingan KK, Keith Keenen E, Strickland M, Li Y, Liu Y, Ball HL, Tanner ME, Tjandra N, Roll-Mecak A. Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Nature Structural & Molecular Biology. PMID 32747782 DOI: 10.1038/S41594-020-0462-0  0.391
2020 Gudimchuk NB, Ulyanov EV, O'Toole E, Page CL, Vinogradov DS, Morgan G, Li G, Moore JK, Szczesna E, Roll-Mecak A, Ataullakhanov FI, Richard McIntosh J. Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography. Nature Communications. 11: 3765. PMID 32724196 DOI: 10.1038/S41467-020-17553-2  0.38
2020 Roll-Mecak A. The Tubulin Code in Microtubule Dynamics and Information Encoding. Developmental Cell. 54: 7-20. PMID 32634400 DOI: 10.1016/J.Devcel.2020.06.008  0.398
2020 Spector JO, Vemu A, Roll-Mecak A. In Vitro Microtubule Dynamics Assays Using Dark-Field Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2101: 39-51. PMID 31879897 DOI: 10.1007/978-1-0716-0219-5_4  0.309
2020 Vemu A, Szczesna E, Roll-Mecak A. In Vitro Reconstitution Assays of Microtubule Amplification and Lattice Repair by the Microtubule-Severing Enzymes Katanin and Spastin. Methods in Molecular Biology (Clifton, N.J.). 2101: 27-38. PMID 31879896 DOI: 10.1007/978-1-0716-0219-5_3  0.437
2019 Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores CA. Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nature Communications. 10: 5236. PMID 31748546 DOI: 10.1038/S41467-019-13247-6  0.428
2019 Zehr EA, Szyk A, Szczesna E, Roll-Mecak A. Katanin Grips the β-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules. Developmental Cell. PMID 31735665 DOI: 10.1016/J.Devcel.2019.10.010  0.443
2019 Roll-Mecak A. A Microtubule-Myelination Connection. Cell. 179: 54-56. PMID 31522889 DOI: 10.1016/J.Cell.2019.08.046  0.301
2019 Sandate CR, Szyk A, Zehr EA, Lander GC, Roll-Mecak A. An allosteric network in spastin couples multiple activities required for microtubule severing. Nature Structural & Molecular Biology. PMID 31285604 DOI: 10.1038/s41594-019-0257-3  0.395
2019 Gudimchuk N, Roll-Mecak A. Watching microtubules grow one tubulin at a time. Proceedings of the National Academy of Sciences of the United States of America. 116: 7163-7165. PMID 30910988 DOI: 10.1073/Pnas.1902991116  0.418
2018 Roll-Mecak A. How cells exploit tubulin diversity to build functional cellular microtubule mosaics. Current Opinion in Cell Biology. 56: 102-108. PMID 30466050 DOI: 10.1016/J.Ceb.2018.10.009  0.387
2018 McNally FJ, Roll-Mecak A. Microtubule-severing enzymes: From cellular functions to molecular mechanism. The Journal of Cell Biology. PMID 30373906 DOI: 10.1083/Jcb.201612104  0.403
2018 Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science (New York, N.Y.). 361. PMID 30139843 DOI: 10.1016/J.Bpj.2018.11.866  0.418
2018 Park JH, Roll-Mecak A. The tubulin code in neuronal polarity. Current Opinion in Neurobiology. 51: 95-102. PMID 29554585 DOI: 10.1016/J.Conb.2018.03.001  0.581
2017 Vemu A, Atherton J, Spector JO, Moores CA, Roll-Mecak A. Tubulin isoform composition tunes microtubule dynamics. Molecular Biology of the Cell. PMID 29021343 DOI: 10.1091/Mbc.E17-02-0124  0.398
2017 Zehr E, Szyk A, Piszczek G, Szczesna E, Zuo X, Roll-Mecak A. Katanin spiral and ring structures shed light on power stroke for microtubule severing. Nature Structural & Molecular Biology. 24: 717-725. PMID 28783150 DOI: 10.1038/Nsmb.3448  0.421
2017 Garnham CP, Yu I, Li Y, Roll-Mecak A. Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28576883 DOI: 10.1073/Pnas.1617286114  0.435
2017 Pigino G, Roll-Mecak A. Microtubule dynamics: 50 years after the discovery of tubulin and still going strong. Molecular Biology of the Cell. 28: 705-706. PMID 28292914 DOI: 10.1091/Mbc.E16-12-0833  0.323
2017 Roll-Mecak A. Readout of the Tubulin Code by Cellular Effectors: Graded Control of Microtubule Severing by Tubulin Glutamylation Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.082  0.414
2016 Sun X, Park JH, Gumerson J, Wu Z, Swaroop A, Qian H, Roll-Mecak A, Li T. Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162334 DOI: 10.1073/Pnas.1523201113  0.551
2016 Vemu A, Atherton J, Spector JO, Szyk A, Moores CA, Roll-Mecak A. Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin. The Journal of Biological Chemistry. PMID 27129203 DOI: 10.1074/Jbc.C116.731133  0.393
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Roll-Mecak A, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882  0.523
2016 Valenstein ML, Roll-Mecak A. Graded Control of Microtubule Severing by Tubulin Glutamylation. Cell. 164: 911-21. PMID 26875866 DOI: 10.1016/J.Cell.2016.01.019  0.405
2015 Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Cell. 161: 1112-23. PMID 25959773 DOI: 10.1016/J.Cell.2015.04.003  0.432
2015 Yu I, Garnham CP, Roll-Mecak A. Writing and Reading the Tubulin Code. The Journal of Biological Chemistry. 290: 17163-72. PMID 25957412 DOI: 10.1074/Jbc.R115.637447  0.369
2015 Roll-Mecak A. Intrinsically disordered tubulin tails: complex tuners of microtubule functions? Seminars in Cell & Developmental Biology. 37: 11-9. PMID 25307498 DOI: 10.1016/J.Semcdb.2014.09.026  0.401
2015 Spector J, Szyk A, Deaconescu AM, Valenstein M, Goodman B, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular Basis for Age-Dependent Acetylation by Tubulin Acetyltransferase Biophysical Journal. 108: 449a. DOI: 10.1016/J.Bpj.2014.11.2449  0.45
2015 Roll-Mecak A, Szyk A, Deaconescu A, Spector J, Valenstein M, Grigorieff N. Molecular Basis for Age-Dependent Microtubule Acetylation Biophysical Journal. 108: 448a. DOI: 10.1016/J.Bpj.2014.11.2447  0.459
2014 Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell. 157: 1405-15. PMID 24906155 DOI: 10.1016/J.Cell.2014.03.061  0.428
2014 Vemu A, Garnham CP, Lee DY, Roll-Mecak A. Generation of differentially modified microtubules using in vitro enzymatic approaches. Methods in Enzymology. 540: 149-66. PMID 24630106 DOI: 10.1016/J.Bpj.2014.11.2453  0.418
2014 Ziółkowska NE, Roll-Mecak A. In vitro microtubule severing assays. Methods in Molecular Biology (Clifton, N.J.). 1046: 323-34. PMID 23868597 DOI: 10.1007/978-1-62703-538-5_19  0.43
2014 Szyk A, Deaconescu A, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase - structural and functional studies Acta Crystallographica Section a Foundations and Advances. 70: C479-C479. DOI: 10.1107/S2053273314095205  0.482
2014 Roll-Mecak A, Szyk A, Kormendi V. Microtubule chemical complexity: mechanism of tubulin modification enzymes Acta Crystallographica Section a Foundations and Advances. 70: C1286-C1286. DOI: 10.1107/S2053273314087130  0.458
2013 Liu Y, Garnham CP, Roll-Mecak A, Tanner ME. Phosphinic acid-based inhibitors of tubulin polyglutamylases Bioorganic and Medicinal Chemistry Letters. 23: 4408-4412. PMID 23777780 DOI: 10.1016/J.Bmcl.2013.05.069  0.306
2013 Szyk A, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro. Journal of Molecular Biology. 425: 2412-4. PMID 23624152 DOI: 10.1016/J.Jmb.2013.04.017  0.4
2012 Kormendi V, Szyk A, Piszczek G, Roll-Mecak A. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus. The Journal of Biological Chemistry. 287: 41569-75. PMID 23105108 DOI: 10.1074/Jbc.C112.421222  0.448
2012 Garnham CP, Roll-Mecak A. The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions. Cytoskeleton (Hoboken, N.J.). 69: 442-63. PMID 22422711 DOI: 10.1002/Cm.21027  0.397
2011 Szyk A, Deaconescu AM, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin. Nature Structural & Molecular Biology. 18: 1250-8. PMID 22020298 DOI: 10.1038/Nsmb.2148  0.478
2010 Roll-Mecak A, McNally FJ. Microtubule-severing enzymes. Current Opinion in Cell Biology. 22: 96-103. PMID 19963362 DOI: 10.1016/J.Ceb.2009.11.001  0.384
2008 Roll-Mecak A, Vale RD. Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature. 451: 363-7. PMID 18202664 DOI: 10.1038/Nature06482  0.459
2006 Roll-Mecak A, Vale RD. Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? The Journal of Cell Biology. 175: 849-51. PMID 17178905 DOI: 10.1083/Jcb.200611149  0.377
2005 Padyana AK, Qiu H, Roll-Mecak A, Hinnebusch AG, Burley SK. Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2α protein kinase GCN2 Journal of Biological Chemistry. 280: 29289-29299. PMID 15964839 DOI: 10.1074/Jbc.M504096200  0.573
2005 Roll-Mecak A, Vale RD. The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Current Biology : Cb. 15: 650-5. PMID 15823537 DOI: 10.1016/J.Cub.2005.02.029  0.352
2005 Padyana AK, Qiu H, Roll-Mecak A, Hinnebusch AG, Burley SK. Structural basis for autoinhibition and activation of eIF2α protein kinase GCN2 Acta Crystallographica Section a Foundations of Crystallography. 61: c233-c234. DOI: 10.1107/S0108767305090045  0.489
2004 Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK. X-ray Structure of Translation Initiation Factor eIF2γ: Implications for tRNA and eIF2α binding Journal of Biological Chemistry. 279: 10634-10642. PMID 14688270 DOI: 10.1074/Jbc.M310418200  0.57
2002 Shin BS, Maag D, Roll-Mecak A, Arefin MS, Burley SK, Lorsch JR, Dever TE. Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Cell. 111: 1015-25. PMID 12507428 DOI: 10.1016/S0092-8674(02)01171-6  0.554
2002 Deaconescu AM, Roll-Mecak A, Bonanno JB, Gerchman SE, Kycia H, Studier FW, Burley SK. X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Proteins. 48: 431-6. PMID 12112709 DOI: 10.1002/Prot.10151  0.495
2002 Deaconescu AM, Roll-Mecak A, Bonanno JB, Gerchman SE, Kycia H, Studier FW, Burley SK. Crystal structure ofSaccharomyces cerevisiaehomologous mitochondrial matrix factor 1 (Hmf1) Acta Crystallographica Section a Foundations of Crystallography. 58: c299-c299. DOI: 10.1107/S0108767302096940  0.468
2002 Roll-Mecak A, Cao C, Dever TE, Burley SK. X-ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding Acta Crystallographica Section a Foundations of Crystallography. 58: c5-c5. DOI: 10.1107/S0108767302085288  0.479
2001 Dever TE, Roll-Mecak A, Choi SK, Lee JH, Cao C, Shin BS, Burley SK. Universal translation initiation factor IF2/eIF5B Cold Spring Harbor Symposia On Quantitative Biology. 66: 417-424. PMID 12762044 DOI: 10.1101/Sqb.2001.66.417  0.483
2001 Roll-Mecak A, Shin BS, Dever TE, Burley SK. Engaging the ribosome: Universal IFs of translation Trends in Biochemical Sciences. 26: 705-709. PMID 11738593 DOI: 10.1016/S0968-0004(01)02024-2  0.55
2000 Roll-Mecak A, Cao C, Dever TE, Burley SK. X-ray structures of the universal translation initiation factor IF2/eIF5B: Conformational changes on GDP and GTP binding Cell. 103: 781-792. PMID 11114334 DOI: 10.1107/S0108767302085288  0.544
2000 Sang Ki Choi, Olsen DS, Roll-Mecak A, Martung A, Remo KL, Burley SK, Hinnebusch AG, Dever TE. Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2 Molecular and Cellular Biology. 20: 7183-7191. PMID 10982835 DOI: 10.1128/Mcb.20.19.7183-7191.2000  0.554
1999 Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2 Proceedings of the National Academy of Sciences of the United States of America. 96: 4342-4347. PMID 10200264 DOI: 10.1073/Pnas.96.8.4342  0.547
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