Jeffrey J. Kovacs, Ph.D. - Publications

Affiliations: 
2005 Duke University, Durham, NC 
Area:
Molecular Biology, Pharmacology

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth. Plos One. 9: e93441. PMID 24736311 DOI: 10.1371/journal.pone.0093441  0.56
2013 Simard E, Kovacs JJ, Miller WE, Kim J, Grandbois M, Lefkowitz RJ. β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. Plos One. 8: e80532. PMID 24255721 DOI: 10.1371/journal.pone.0080532  0.56
2012 Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T. β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 12532-7. PMID 22773819 DOI: 10.1073/pnas.1209815109  0.56
2012 Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, et al. Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107) Proceedings of the National Academy of Sciences of the United States of America. 109: 13464. DOI: 10.1073/pnas.1211889109  0.56
2011 Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53. PMID 21857681 DOI: 10.1038/nature10368  0.56
2011 Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW. β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Science Translational Medicine. 3: 74ra23. PMID 21411739 DOI: 10.1126/scitranslmed.3001564  0.56
2010 Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United States of America. 107: 15299-304. PMID 20686112 DOI: 10.1073/pnas.1008461107  0.56
2009 Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Developmental Cell. 17: 443-58. PMID 19853559 DOI: 10.1016/j.devcel.2009.09.011  0.56
2009 Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/JCI36806  0.56
2008 Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (New York, N.Y.). 320: 1777-81. PMID 18497258 DOI: 10.1126/science.1157983  0.56
2007 Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P. Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. Journal of Molecular Biology. 370: 290-302. PMID 17512543 DOI: 10.1016/j.jmb.2007.04.015  0.56
2005 Kovacs JJ, Cohen TJ, Yao TP. Chaperoning steroid hormone signaling via reversible acetylation. Nuclear Receptor Signaling. 3: e004. PMID 16604172 DOI: 10.1621/nrs.03004  0.96
2005 Murphy PJ, Morishima Y, Kovacs JJ, Yao TP, Pratt WB. Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. The Journal of Biological Chemistry. 280: 33792-9. PMID 16087666 DOI: 10.1074/jbc.M506997200  0.56
2005 Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Molecular Cell. 18: 601-7. PMID 15916966 DOI: 10.1016/j.molcel.2005.04.021  0.56
2004 Kovacs JJ, Hubbert C, Yao TP. The HDAC complex and cytoskeleton. Novartis Foundation Symposium. 259: 170-7; discussion 17. PMID 15171253  0.96
2003 Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell. 115: 727-38. PMID 14675537 DOI: 10.1016/S0092-8674(03)00939-5  0.56
2002 Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. The Embo Journal. 21: 6236-45. PMID 12426395 DOI: 10.1093/emboj/cdf616  0.96
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