☰

Jeffrey J. Kovacs, Ph.D. - Publications

Affiliations: 
2005 Duke University, Durham, NC 
Area:
Molecular Biology, Pharmacology
Tree Info Grants Similar researchers Related pubs Distance to... Nearest Nobel PubMed Report error

18/31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S. Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1. Circulation. PMID 30586762 DOI: 10.1161/Circulationaha.118.034961  0.697
2014 Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth. Plos One. 9: e93441. PMID 24736311 DOI: 10.1371/Journal.Pone.0093441  0.72
2013 Simard E, Kovacs JJ, Miller WE, Kim J, Grandbois M, Lefkowitz RJ. β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. Plos One. 8: e80532. PMID 24255721 DOI: 10.1371/Journal.Pone.0080532  0.685
2012 Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T. β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 12532-7. PMID 22773819 DOI: 10.1073/Pnas.1209815109  0.779
2012 Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, et al. Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107) Proceedings of the National Academy of Sciences of the United States of America. 109: 13464. DOI: 10.1073/Pnas.1211889109  0.71
2011 Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53. PMID 21857681 DOI: 10.1038/Nature10368  0.682
2011 Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW. β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Science Translational Medicine. 3: 74ra23. PMID 21411739 DOI: 10.1126/scitranslmed.3001564  0.39
2010 Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United States of America. 107: 15299-304. PMID 20686112 DOI: 10.1073/Pnas.1008461107  0.748
2009 Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Developmental Cell. 17: 443-58. PMID 19853559 DOI: 10.1016/J.Devcel.2009.09.011  0.718
2009 Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/Jci36806  0.705
2008 Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (New York, N.Y.). 320: 1777-81. PMID 18497258 DOI: 10.1126/Science.1157983  0.762
2007 Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P. Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. Journal of Molecular Biology. 370: 290-302. PMID 17512543 DOI: 10.1016/J.Jmb.2007.04.015  0.605
2005 Kovacs JJ, Cohen TJ, Yao TP. Chaperoning steroid hormone signaling via reversible acetylation. Nuclear Receptor Signaling. 3: e004. PMID 16604172 DOI: 10.1621/Nrs.03004  0.752
2005 Murphy PJ, Morishima Y, Kovacs JJ, Yao TP, Pratt WB. Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. The Journal of Biological Chemistry. 280: 33792-9. PMID 16087666 DOI: 10.1074/Jbc.M506997200  0.638
2005 Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Molecular Cell. 18: 601-7. PMID 15916966 DOI: 10.1016/J.Molcel.2005.04.021  0.669
2004 Kovacs JJ, Hubbert C, Yao TP. The HDAC complex and cytoskeleton. Novartis Foundation Symposium. 259: 170-7; discussion 17. PMID 15171253 DOI: 10.1002/0470862637.Ch12  0.722
2003 Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell. 115: 727-38. PMID 14675537 DOI: 10.1016/S0092-8674(03)00939-5  0.634
2002 Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. The Embo Journal. 21: 6236-45. PMID 12426395 DOI: 10.1093/Emboj/Cdf616  0.598
Low-probability matches (unlikely to be authored by this person)
2021 Czako B, Sun Y, McAfoos T, Cross JB, Leonard PG, Burke JP, Carroll CL, Feng N, Harris AL, Jiang Y, Kang Z, Kovacs JJ, Mandal P, Meyers BA, Mseeh F, et al. Discovery of 6-[(3,4)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. Journal of Medicinal Chemistry. PMID 34643390 DOI: 10.1021/acs.jmedchem.1c01132  0.226
2021 Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, ... ... Kovacs JJ, et al. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nature Communications. 12: 4626. PMID 34330913 DOI: 10.1038/s41467-021-24798-y  0.178
2020 Sun Y, Meyers BA, Czako B, Leonard P, Mseeh F, Harris AL, Wu Q, Johnson S, Parker CA, Cross JB, Di Francesco ME, Bivona BJ, Bristow CA, Burke JP, Carrillo CC, ... ... Kovacs JJ, et al. Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib. Cancer Research. PMID 32928921 DOI: 10.1158/0008-5472.Can-20-1634  0.175
2023 Vellano CP, White MG, Andrews MC, Chelvanambi M, Witt RG, Daniele JR, Titus M, McQuade JL, Conforti F, Burton EM, Lastrapes MJ, Ologun G, Cogdill AP, Morad G, Prieto P, ... ... Kovacs JJ, et al. Author Correction: Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy. Nature. PMID 36627494 DOI: 10.1038/s41586-022-05632-x  0.144
2018 Baran N, Lodi A, Sweeney SR, Renu P, Kuruvilla VM, Cavazos A, Herranz D, Skwarska A, Warmoes M, Davis RE, Harutyunyan K, Feng N, Gay JP, Konoplev SN, Kaminski M, ... Kovacs JJ, et al. Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition Blood. 132: 4020-4020. DOI: 10.1182/Blood-2018-99-117310  0.137
2022 Vellano CP, White MG, Andrews MC, Chelvanambi M, Witt RG, Daniele JR, Titus M, McQuade JL, Conforti F, Burton EM, Lastrapes MJ, Ologun G, Cogdill AP, Morad G, Prieto P, ... ... Kovacs JJ, et al. Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy. Nature. PMID 35705814 DOI: 10.1038/s41586-022-04833-8  0.133
2021 Konen JM, Rodriguez BL, Padhye A, Ochieng JK, Gibson L, Diao L, Fowlkes NW, Fradette JJ, Peng DH, Cardnell RJ, Kovacs JJ, Wang J, Byers LA, Gibbons DL. Dual inhibition of MEK and AXL targets tumor cell heterogeneity and prevents resistant outgrowth mediated by the epithelial-to-mesenchymal transition in NSCLC. Cancer Research. PMID 33402388 DOI: 10.1158/0008-5472.CAN-20-1895  0.123
2019 Konen JM, Rodriguez BL, Fradette JJ, Gibson L, Davis D, Minelli R, Peoples MD, Kovacs J, Carugo A, Bristow C, Heffernan T, Gibbons DL. Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer. Cancers. 11. PMID 30986992 DOI: 10.3390/Cancers11040462  0.116
2018 Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, et al. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 23: 700-713.e6. PMID 30388424 DOI: 10.1016/J.Stem.2018.10.004  0.109
2019 Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, et al. ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer. Nature Communications. 10: 5125. PMID 31719531 DOI: 10.1038/S41467-019-12832-Z  0.105
2023 Osman AA, Arslan E, Bartels M, Michikawa C, Lindemann A, Tomczak K, Yu W, Sandulache V, Ma W, Shen L, Wang J, Singh AK, Frederick MJ, Spencer ND, Kovacs J, et al. Dysregulation and epigenetic reprogramming of NRF2 signaling axis promote acquisition of cisplatin resistance and metastasis in Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36689560 DOI: 10.1158/1078-0432.CCR-22-2747  0.096
2020 Soth MJ, Le K, Di Francesco ME, Hamilton MM, Liu G, Burke JP, Carroll CL, Kovacs JJ, Bardenhagen JP, Bristow CA, Cardozo M, Czako B, de Stanchina E, Feng N, Garvey JR, et al. Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. Journal of Medicinal Chemistry. PMID 33118821 DOI: 10.1021/acs.jmedchem.0c01398  0.067
2022 Schmidt ST, Akhave N, Knightly RE, Reuben A, Vokes N, Zhang J, Li J, Fujimoto J, Byers LA, Sanchez-Espiridion B, Diao L, Wang J, Federico L, Forget MA, McGrail DJ, ... ... Kovacs JJ, et al. Shared Nearest Neighbors Approach and Interactive Browser for Network Analysis of a Comprehensive Non-Small-Cell Lung Cancer Data Set. Jco Clinical Cancer Informatics. 6: e2200040. PMID 35944232 DOI: 10.1200/CCI.22.00040  0.058
Hide low-probability matches.