| Year |
Citation |
Score |
| 2023 |
Prucha GR, Henry S, Hollander K, Carter ZJ, Spasov KA, Jorgensen WL, Anderson KS. Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. European Journal of Medicinal Chemistry. 262: 115894. PMID 37883896 DOI: 10.1016/j.ejmech.2023.115894 |
0.49 |
|
| 2023 |
Hollander K, Chan AH, Frey KM, Hunker O, Ippolito JA, Spasov KA, Yeh YJ, Jorgensen WL, Ho YC, Anderson KS. Exploring Novel HIV-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise. Protein Science : a Publication of the Protein Society. e4814. PMID 37861472 DOI: 10.1002/pro.4814 |
0.761 |
|
| 2023 |
Carter ZJ, Hollander K, Spasov KA, Anderson KS, Jorgensen WL. Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 84: 129216. PMID 36871704 DOI: 10.1016/j.bmcl.2023.129216 |
0.415 |
|
| 2022 |
Gannam ZTK, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS. Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors. European Journal of Medicinal Chemistry. 243: 114712. PMID 36116232 DOI: 10.1016/j.ejmech.2022.114712 |
0.307 |
|
| 2022 |
Frey KM, Bertoletti N, Chan AH, Ippolito JA, Bollini M, Spasov KA, Jorgensen WL, Anderson KS. Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Frontiers in Molecular Biosciences. 9: 805187. PMID 35237658 DOI: 10.3389/fmolb.2022.805187 |
0.751 |
|
| 2022 |
Beloor J, Kudalkar SN, Buzzelli G, Yang F, Mandl HK, Rajashekar JK, Spasov KA, Jorgensen WL, Saltzman WM, Anderson KS, Kumar P. Long-acting and extended-release implant and nanoformulations with a synergistic antiretroviral two-drug combination controls HIV-1 infection in a humanized mouse model. Bioengineering & Translational Medicine. 7: e10237. PMID 35079625 DOI: 10.1002/btm2.10237 |
0.31 |
|
| 2021 |
Deshmukh MG, Ippolito JA, Zhang CH, Stone EA, Reilly RA, Miller SJ, Jorgensen WL, Anderson KS. Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease. Structure (London, England : 1993). PMID 34161756 DOI: 10.1016/j.str.2021.06.002 |
0.301 |
|
| 2021 |
Ippolito JA, Niu H, Bertoletti N, Carter ZJ, Jin S, Spasov KA, Cisneros JA, Valhondo M, Cutrona KJ, Anderson KS, Jorgensen WL. Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead. Acs Medicinal Chemistry Letters. 12: 249-255. PMID 33603971 DOI: 10.1021/acsmedchemlett.0c00612 |
0.442 |
|
| 2020 |
Bertoletti N, Chan AH, Schinazi RF, Anderson KS. Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. Molecules (Basel, Switzerland). 25. PMID 33096918 DOI: 10.3390/molecules25204868 |
0.4 |
|
| 2020 |
Duong VN, Ippolito JA, Chan AH, Lee WG, Spasov KA, Jorgensen WL, Anderson KS. Structural Investigation of 2-Naphthyl Phenyl Ether Inhibitors Bound to WT and Y181C Reverse Transcriptase Highlights Key Features of the NNRTI Binding Site. Protein Science : a Publication of the Protein Society. PMID 32643196 DOI: 10.1002/Pro.3910 |
0.402 |
|
| 2020 |
Ruiz VG, Czyzyk DJ, Kumar VP, Jorgensen WL, Anderson KS. Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors. Bioorganic & Medicinal Chemistry Letters. 30: 127292. PMID 32631514 DOI: 10.1016/J.Bmcl.2020.127292 |
0.303 |
|
| 2020 |
Duong VN, Zhou L, Martínez-Jiménez MI, He L, Cosme M, Blanco L, Paintsil E, Anderson KS. Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient. Scientific Reports. 10: 9343. PMID 32518272 DOI: 10.1038/s41598-020-66153-z |
0.366 |
|
| 2019 |
Bertoletti N, Chan AH, Schinazi RF, Yin YW, Anderson KS. Structural insights into the recognition of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) by HIV-1 reverse transcriptase: First crystal structures with RT and the active triphosphate forms of lamivudine and emtricitabine. Protein Science : a Publication of the Protein Society. PMID 31301259 DOI: 10.1002/Pro.3681 |
0.524 |
|
| 2019 |
Sasaki T, Gannam ZTK, Kudalkar SN, Frey KM, Lee WG, Spasov KA, Jorgensen WL, Anderson KS. Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. PMID 31281023 DOI: 10.1016/J.Bmcl.2019.06.047 |
0.765 |
|
| 2019 |
Czyzyk DJ, Valhondo M, Jorgensen WL, Anderson KS. Understanding the Structural Basis of Species Selective, Stereospecific Inhibition for Cryptosporidium and Human Thymidylate Synthase. Febs Letters. PMID 31172516 DOI: 10.1002/1873-3468.13474 |
0.361 |
|
| 2019 |
Kudalkar SN, Ullah I, Bertoletti N, Mandl HK, Cisneros JA, Beloor J, Chan AH, Quijano E, Saltzman WM, Jorgensen WL, Kumar P, Anderson KS. Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV. Antiviral Research. PMID 31034849 DOI: 10.1016/J.Antiviral.2019.04.010 |
0.524 |
|
| 2019 |
Ruiz V, Czyzyk DJ, Valhondo M, Jorgensen WL, Anderson KS. Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening. Bioorganic & Medicinal Chemistry Letters. PMID 30929953 DOI: 10.1016/J.Bmcl.2019.03.022 |
0.422 |
|
| 2019 |
Cannataro VL, Gaffney SG, Sasaki T, Issaeva N, Grewal NKS, Grandis JR, Yarbrough WG, Burtness B, Anderson KS, Townsend JP. APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. Oncogene. PMID 30647454 DOI: 10.1038/S41388-018-0657-6 |
0.3 |
|
| 2018 |
Ryan MR, Sohl CD, Luo B, Anderson KS. The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT. Molecular Cancer Research : McR. PMID 30257990 DOI: 10.1158/1541-7786.Mcr-18-0429 |
0.706 |
|
| 2018 |
Sasaki T, Kudalkar SN, Bertoletti N, Anderson KS. DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities. Analytical Chemistry. PMID 30256094 DOI: 10.1021/Acs.Analchem.8B01405 |
0.309 |
|
| 2018 |
Yang M, Wu H, Chu J, Gabriel LA, Kim Y, Anderson KS, Furdui CM, Bierbach U. Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent. Chemical Communications (Cambridge, England). PMID 29915817 DOI: 10.1039/C8Cc04251A |
0.326 |
|
| 2018 |
Ziegler SJ, Liu C, Landau M, Buzovetsky O, Desimmie BA, Zhao Q, Sasaki T, Burdick RC, Pathak VK, Anderson KS, Xiong Y. Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. Plos One. 13: e0195048. PMID 29596531 DOI: 10.1371/Journal.Pone.0195048 |
0.368 |
|
| 2017 |
Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS. From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279368 DOI: 10.1073/Pnas.1717932115 |
0.501 |
|
| 2017 |
Chan AH, Lee WG, Spasov KA, Cisneros JA, Kudalkar SN, Petrova ZO, Buckingham AB, Anderson KS, Jorgensen WL. Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827354 DOI: 10.1073/Pnas.1711463114 |
0.538 |
|
| 2017 |
Anderson KS. Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR. Protein Engineering, Design & Selection : Peds. 253-261. PMID 28338744 DOI: 10.1093/Protein/Gzx004 |
0.338 |
|
| 2017 |
Kudalkar SN, Beloor J, Chan AH, Lee WG, Jorgensen WL, Kumar P, Anderson KS. Structural and Preclinical Studies of Computationally-Designed Non-nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection. Molecular Pharmacology. PMID 28167742 DOI: 10.1124/Mol.116.107755 |
0.479 |
|
| 2016 |
Lee WG, Chan AH, Spasov KA, Anderson KS, Jorgensen WL. Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. Acs Medicinal Chemistry Letters. 7: 1156-1160. PMID 27994756 DOI: 10.1021/Acsmedchemlett.6B00390 |
0.504 |
|
| 2016 |
Li M, Mislak AC, Foli Y, Agbosu E, Bose V, Bhandari S, Szymanski MR, Shumate CK, Yin YW, Anderson KS, Paintsil E. DNA Polymerase-γ R953C Mutant is Associated with ART-Induced Mitochondrial Toxicity. Antimicrobial Agents and Chemotherapy. PMID 27381400 DOI: 10.1128/Aac.00976-16 |
0.379 |
|
| 2015 |
Mislak AC, Anderson KS. Insights into the Molecular Mechanism of Polymerization and NRTI Incorporation for Human PrimPol. Antimicrobial Agents and Chemotherapy. PMID 26552983 DOI: 10.1128/Aac.02270-15 |
0.417 |
|
| 2015 |
Gray WT, Frey KM, Laskey SB, Mislak AC, Spasov KA, Lee WG, Bollini M, Siliciano RF, Jorgensen WL, Anderson KS. Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. Acs Medicinal Chemistry Letters. 6: 1075-9. PMID 26487915 DOI: 10.1021/Acsmedchemlett.5B00254 |
0.775 |
|
| 2015 |
Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL. Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 25: 4824-7. PMID 26166629 DOI: 10.1016/J.Bmcl.2015.06.074 |
0.777 |
|
| 2015 |
Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW. Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ. Proceedings of the National Academy of Sciences of the United States of America. 112: 8596-601. PMID 26124101 DOI: 10.1073/Pnas.1421733112 |
0.764 |
|
| 2015 |
Mukerjee A, Iyidogan P, Castellanos-Gonzalez A, Cisneros JA, Czyzyk D, Ranjan AP, Jorgensen WL, White AC, Vishwanatha JK, Anderson KS. A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium. Bioorganic & Medicinal Chemistry Letters. 25: 2065-7. PMID 25900220 DOI: 10.1016/J.Bmcl.2015.03.091 |
0.33 |
|
| 2015 |
Frey KM, Puleo DE, Spasov KA, Bollini M, Jorgensen WL, Anderson KS. Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants. Journal of Medicinal Chemistry. 58: 2737-45. PMID 25700160 DOI: 10.1021/Jm501908A |
0.757 |
|
| 2015 |
Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29. PMID 25686244 DOI: 10.1021/Acschembio.5B00014 |
0.79 |
|
| 2015 |
Kim Y, Apetri M, Luo B, Settleman JE, Anderson KS. Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors. Molecular Cancer Research : McR. 13: 765-74. PMID 25573954 DOI: 10.1158/1541-7786.Mcr-14-0326 |
0.349 |
|
| 2015 |
Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular ,mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: The Achilles' heel of targeted therapy Acs Chemical Biology. 10: 1319-1329. DOI: 10.1021/acschembio.5b00014 |
0.772 |
|
| 2015 |
Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL. Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.06.074 |
0.745 |
|
| 2014 |
Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. Acs Medicinal Chemistry Letters. 5: 1259-62. PMID 25408842 DOI: 10.1021/Ml5003713 |
0.768 |
|
| 2014 |
Parker CG, Dahlgren MK, Tao RN, Li DT, Douglass EF, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, et al. Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules. Chemical Science (Royal Society of Chemistry : 2010). 5: 2311-2317. PMID 25379167 DOI: 10.1039/C4Sc00484A |
0.441 |
|
| 2014 |
Iyidogan P, Anderson KS. Current perspectives on HIV-1 antiretroviral drug resistance. Viruses. 6: 4095-139. PMID 25341668 DOI: 10.3390/V6104095 |
0.433 |
|
| 2014 |
Kumar VP, Cisneros JA, Frey KM, Castellanos-Gonzalez A, Wang Y, Gangjee A, White AC, Jorgensen WL, Anderson KS. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorganic & Medicinal Chemistry Letters. 24: 4158-61. PMID 25127103 DOI: 10.1016/J.Bmcl.2014.07.049 |
0.726 |
|
| 2014 |
Towle-Weicksel JB, Dalal S, Sohl CD, Doublie S, Anderson KS, Sweasy JB. Fluorescence resonance energy transfer studies of DNA polymerase β the critical role of fingers domain movements and a novel non-covalent step During nucleotide selection Journal of Biological Chemistry. 289: 16541-16550. PMID 24764311 DOI: 10.1074/Jbc.M114.561878 |
0.674 |
|
| 2014 |
Mislak AC, Frey KM, Bollini M, Jorgensen WL, Anderson KS. A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochimica Et Biophysica Acta. 1840: 2203-11. PMID 24726448 DOI: 10.1016/J.Bbagen.2014.04.001 |
0.763 |
|
| 2014 |
Muftuoglu Y, Sohl CD, Mislak AC, Mitsuya H, Sarafianos SG, Anderson KS. Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics. Antiviral Research. 106: 1-4. PMID 24632447 DOI: 10.1016/J.Antiviral.2014.03.001 |
0.767 |
|
| 2014 |
Sharma H, Landau MJ, Sullivan TJ, Kumar VP, Dahlgren MK, Jorgensen WL, Anderson KS. Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase. Bioorganic & Medicinal Chemistry Letters. 24: 1232-5. PMID 24440298 DOI: 10.1016/J.Bmcl.2013.12.039 |
0.391 |
|
| 2014 |
Frey KM, Gray WT, Spasov KA, Bollini M, Gallardo-Macias R, Jorgensen WL, Anderson KS. Structure-based evaluation of C5 derivatives in the catechol diether series targeting HIV-1 reverse transcriptase. Chemical Biology & Drug Design. 83: 541-9. PMID 24289305 DOI: 10.1111/Cbdd.12266 |
0.718 |
|
| 2014 |
Iyidogan P, Anderson KS. Recent findings on the mechanisms involved in tenofovir resistance. Antiviral Chemistry & Chemotherapy. 23: 217-22. PMID 23744599 DOI: 10.3851/Imp2628 |
0.438 |
|
| 2013 |
Iyidogan P, Sullivan TJ, Chordia MD, Frey KM, Anderson KS. Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase. Acs Medicinal Chemistry Letters. 4: 1183-8. PMID 24900627 DOI: 10.1021/Ml4002979 |
0.757 |
|
| 2013 |
Lee WG, Gallardo-Macias R, Frey KM, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group. Journal of the American Chemical Society. 135: 16705-13. PMID 24151856 DOI: 10.1021/Ja408917N |
0.77 |
|
| 2013 |
Sharma H, Landau MJ, Vargo MA, Spasov KA, Anderson KS. First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling. Biochemistry. 52: 7305-17. PMID 24053355 DOI: 10.1021/Bi400576T |
0.384 |
|
| 2013 |
Bollini M, Cisneros JA, Spasov KA, Anderson KS, Jorgensen WL. Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility. Bioorganic & Medicinal Chemistry Letters. 23: 5213-6. PMID 23937980 DOI: 10.1016/J.Bmcl.2013.06.091 |
0.511 |
|
| 2013 |
Kumar VP, Frey KM, Wang Y, Jain HK, Gangjee A, Anderson KS. Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5426-8. PMID 23927969 DOI: 10.1016/J.Bmcl.2013.07.037 |
0.727 |
|
| 2013 |
Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL. Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility. Bioorganic & Medicinal Chemistry Letters. 23: 5209-12. PMID 23899617 DOI: 10.1016/J.Bmcl.2013.06.093 |
0.73 |
|
| 2013 |
Landau MJ, Sharma H, Anderson KS. Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation. Protein Science : a Publication of the Protein Society. 22: 1161-73. PMID 23813474 DOI: 10.1002/Pro.2300 |
0.335 |
|
| 2013 |
Bailey CM, Sullivan TJ, Iyidogan P, Tirado-Rives J, Chung R, Ruiz-Caro J, Mohamed E, Jorgensen WL, Jorgensen W, Hunter R, Anderson KS. Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy. Journal of Medicinal Chemistry. 56: 3959-68. PMID 23659183 DOI: 10.1021/Jm400160S |
0.542 |
|
| 2013 |
Piao D, Basavapathruni A, Iyidogan P, Dai G, Hinz W, Ray AS, Murakami E, Feng JY, You F, Dutschman GE, Austin DJ, Parker KA, Anderson KS. Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate. Bioorganic & Medicinal Chemistry Letters. 23: 1511-8. PMID 23380374 DOI: 10.1016/J.Bmcl.2012.12.015 |
0.438 |
|
| 2013 |
Bollini M, Gallardo-Macias R, Spasov KA, Tirado-Rives J, Anderson KS, Jorgensen WL. Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency. Bioorganic & Medicinal Chemistry Letters. 23: 1110-3. PMID 23298809 DOI: 10.1016/J.Bmcl.2012.11.115 |
0.481 |
|
| 2013 |
Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS. Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Human Molecular Genetics. 22: 1074-85. PMID 23208208 DOI: 10.1093/Hmg/Dds509 |
0.672 |
|
| 2012 |
Frey KM, Bollini M, Mislak AC, Cisneros JA, Gallardo-Macias R, Jorgensen WL, Anderson KS. Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design. Journal of the American Chemical Society. 134: 19501-3. PMID 23163887 DOI: 10.1021/Ja3092642 |
0.762 |
|
| 2012 |
Iyidogan P, Anderson KS. Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract. Antiviral Research. 95: 93-103. PMID 22664235 DOI: 10.1016/J.Antiviral.2012.05.012 |
0.457 |
|
| 2012 |
Kim Y, Li Z, Apetri M, Luo B, Settleman JE, Anderson KS. Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib. Biochemistry. 51: 5212-22. PMID 22657099 DOI: 10.1021/Bi300476V |
0.346 |
|
| 2012 |
Kim J, Wang L, Li Y, Becnel KD, Frey KM, Garforth SJ, Prasad VR, Schinazi RF, Liotta DC, Anderson KS. Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. 22: 4064-4067. PMID 22595174 DOI: 10.1016/J.Bmcl.2012.04.078 |
0.768 |
|
| 2012 |
Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS. Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase. Molecular Pharmacology. 82: 125-33. PMID 22513406 DOI: 10.1124/Mol.112.078758 |
0.768 |
|
| 2012 |
Ekkati AR, Bollini M, Domaoal RA, Spasov KA, Anderson KS, Jorgensen WL. Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 22: 1565-8. PMID 22269110 DOI: 10.1016/J.Bmcl.2011.12.132 |
0.507 |
|
| 2012 |
Kim J, Roberts A, Yuan H, Xiong Y, Anderson KS. Nucleocapsid protein annealing of a primer-template enhances (+)-strand DNA synthesis and fidelity by HIV-1 reverse transcriptase. Journal of Molecular Biology. 415: 866-80. PMID 22210155 DOI: 10.1016/J.Jmb.2011.12.034 |
0.451 |
|
| 2012 |
Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity. Antimicrobial Agents and Chemotherapy. 56: 1630-4. PMID 22155823 DOI: 10.1128/Aac.05729-11 |
0.725 |
|
| 2011 |
Dermenci A, Selig PS, Domaoal RA, Spasov KA, Anderson KS, Miller SJ. Quasi-Biomimetic Ring Contraction Catalyzed by a Cysteine-Based Nucleophile: Total Synthesis of Sch-642305, Some Analogs and their Putative anti-HIV Activities. Chemical Science (Royal Society of Chemistry : 2010). 2. PMID 24179673 DOI: 10.1039/C1Sc00221J |
0.323 |
|
| 2011 |
Bollini M, Domaoal RA, Thakur VV, Gallardo-Macias R, Spasov KA, Anderson KS, Jorgensen WL. Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents. Journal of Medicinal Chemistry. 54: 8582-91. PMID 22081993 DOI: 10.1021/Jm201134M |
0.443 |
|
| 2011 |
Jorgensen WL, Bollini M, Thakur VV, Domaoal RA, Spasov KA, Anderson KS. Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase. Journal of the American Chemical Society. 133: 15686-96. PMID 21853995 DOI: 10.1021/Ja2058583 |
0.529 |
|
| 2010 |
Younis Y, Hunter R, Muhanji CI, Hale I, Singh R, Bailey CM, Sullivan TJ, Anderson KS. [d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase. Bioorganic & Medicinal Chemistry. 18: 4661-73. PMID 20605472 DOI: 10.1016/J.Bmc.2010.05.025 |
0.348 |
|
| 2010 |
Garforth SJ, Domaoal RA, Lwatula C, Landau MJ, Meyer AJ, Anderson KS, Prasad VR. K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies. Journal of Molecular Biology. 401: 33-44. PMID 20538005 DOI: 10.1016/J.Jmb.2010.06.001 |
0.303 |
|
| 2010 |
Roberts A, Furdui C, Anderson KS. Observation of a chemically labile, noncovalent enzyme intermediate in the reaction of metal-dependent Aquifex pyrophilus KDO8PS by time-resolved mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 24: 1919-24. PMID 20533322 DOI: 10.1002/Rcm.4594 |
0.3 |
|
| 2010 |
Leung CS, Zeevaart JG, Domaoal RA, Bollini M, Thakur VV, Spasov KA, Anderson KS, Jorgensen WL. Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives. Bioorganic & Medicinal Chemistry Letters. 20: 2485-8. PMID 20304641 DOI: 10.1016/J.Bmcl.2010.03.006 |
0.494 |
|
| 2010 |
Painter GR, Anderson K, Bouygues M, Joubert M, Liotta D. ChemInform Abstract: Virally Encoded Polymerases as Targets for Chemotherapy: Application to HIV and HBV Cheminform. 33: no-no. DOI: 10.1002/chin.200248256 |
0.309 |
|
| 2009 |
Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An antibody-recruiting small molecule that targets HIV gp120. Journal of the American Chemical Society. 131: 16392-4. PMID 19839582 DOI: 10.1021/Ja9057647 |
0.419 |
|
| 2009 |
Nichols SE, Domaoal RA, Thakur VV, Tirado-Rives J, Anderson KS, Jorgensen WL. Discovery of wild-type and Y181C mutant non-nucleoside HIV-1 reverse transcriptase inhibitors using virtual screening with multiple protein structures. Journal of Chemical Information and Modeling. 49: 1272-9. PMID 19374380 DOI: 10.1021/Ci900068K |
0.534 |
|
| 2009 |
Lew ED, Furdui CM, Anderson KS, Schlessinger J. The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Science Signaling. 2: ra6. PMID 19224897 DOI: 10.1126/Scisignal.2000021 |
0.321 |
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| 2009 |
Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS. Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. Acs Chemical Biology. 4: 29-40. PMID 19146480 DOI: 10.1021/Cb8002804 |
0.428 |
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| 2009 |
Martucci WE, Udier-Blagovic M, Atreya C, Babatunde O, Vargo MA, Jorgensen WL, Anderson KS. Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen. Bioorganic & Medicinal Chemistry Letters. 19: 418-23. PMID 19059777 DOI: 10.1016/J.Bmcl.2008.11.054 |
0.409 |
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| 2009 |
Vargo MA, Martucci WE, Anderson KS. Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis. The Biochemical Journal. 417: 757-64. PMID 18851711 DOI: 10.1042/Bj20081247 |
0.367 |
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| 2008 |
Hunter R, Younis Y, Muhanji CI, Curtin TL, Naidoo KJ, Petersen M, Bailey CM, Basavapathruni A, Anderson KS. C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 16: 10270-80. PMID 18996020 DOI: 10.1016/j.bmc.2008.10.048 |
0.386 |
|
| 2008 |
Martucci WE, Vargo MA, Anderson KS. Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase. Biochemistry. 47: 8902-11. PMID 18672899 DOI: 10.1021/Bi800466Z |
0.374 |
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| 2008 |
Zeevaart JG, Wang L, Thakur VV, Leung CS, Tirado-Rives J, Bailey CM, Domaoal RA, Anderson KS, Jorgensen WL. Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations. Journal of the American Chemical Society. 130: 9492-9. PMID 18588301 DOI: 10.1021/Ja8019214 |
0.473 |
|
| 2008 |
Shen L, Peterson S, Sedaghat AR, McMahon MA, Callender M, Zhang H, Zhou Y, Pitt E, Anderson KS, Acosta EP, Siliciano RF. Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nature Medicine. 14: 762-6. PMID 18552857 DOI: 10.1038/Nm1777 |
0.369 |
|
| 2008 |
Dasgupta T, Anderson KS. Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry. 47: 1336-45. PMID 18189414 DOI: 10.1021/Bi701624U |
0.348 |
|
| 2008 |
Domaoal RA, McMahon M, Thio CL, Bailey CM, Tirado-Rives J, Obikhod A, Detorio M, Rapp KL, Siliciano RF, Schinazi RF, Anderson KS. Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 283: 5452-9. PMID 17962184 DOI: 10.1074/Jbc.M707834200 |
0.544 |
|
| 2007 |
Barreiro G, Kim JT, Guimarães CR, Bailey CM, Domaoal RA, Wang L, Anderson KS, Jorgensen WL. From docking false-positive to active anti-HIV agent. Journal of Medicinal Chemistry. 50: 5324-9. PMID 17918923 DOI: 10.1021/Jm070683U |
0.474 |
|
| 2007 |
Xia Q, Radzio J, Anderson KS, Sluis-Cremer N. Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Science : a Publication of the Protein Society. 16: 1728-37. PMID 17656585 DOI: 10.1110/Ps.072829007 |
0.371 |
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| 2007 |
Basavapathruni A, Anderson KS. Reverse transcription of the HIV-1 pandemic. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3795-808. PMID 17639073 DOI: 10.1096/Fj.07-8697Rev |
0.512 |
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| 2007 |
Doan LT, Martucci WE, Vargo MA, Atreya CE, Anderson KS. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis. Biochemistry. 46: 8379-91. PMID 17580969 DOI: 10.1021/Bi700531R |
0.36 |
|
| 2007 |
Nakata H, Amano M, Koh Y, Kodama E, Yang G, Bailey CM, Kohgo S, Hayakawa H, Matsuoka M, Anderson KS, Cheng YC, Mitsuya H. Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Antimicrobial Agents and Chemotherapy. 51: 2701-8. PMID 17548498 DOI: 10.1128/AAC.00277-07 |
0.301 |
|
| 2007 |
Murakami E, Bao H, Basavapathruni A, Bailey CM, Du J, Steuer HM, Niu C, Whitaker T, Anderson KS, Otto MJ, Furman PA. Mechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent. Antiviral Chemistry & Chemotherapy. 18: 83-92. PMID 17542153 |
0.404 |
|
| 2007 |
Ray AS, Feng JY, Murakami E, Chu CK, Schinazi RF, Anderson KS. Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma. Antiviral Chemistry & Chemotherapy. 18: 25-33. PMID 17354649 |
0.355 |
|
| 2007 |
Hunter R, Muhanji CI, Hale I, Bailey CM, Basavapathruni A, Anderson KS. [d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor. Bioorganic & Medicinal Chemistry Letters. 17: 2614-7. PMID 17317163 DOI: 10.1016/j.bmcl.2007.01.107 |
0.426 |
|
| 2007 |
Yang G, Dutschman GE, Wang CJ, Tanaka H, Baba M, Anderson KS, Cheng YC. Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT. Antiviral Research. 73: 185-91. PMID 17109975 DOI: 10.1016/J.Antiviral.2006.10.002 |
0.49 |
|
| 2007 |
Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Wang L, Anderson KS, Jorgensen WL. FEP-Guided Selection of Bicyclic Heterocycles in Lead Optimization for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase [J. Am. Chem. Soc.2006,128, 15372−15373]. Journal of the American Chemical Society. 129: 3027-3027. DOI: 10.1021/Ja076881S |
0.355 |
|
| 2006 |
Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Domoal RA, Wang L, Anderson KS, Jorgensen WL. FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase. Journal of the American Chemical Society. 128: 15372-3. PMID 17131993 DOI: 10.1021/Ja066472G |
0.496 |
|
| 2006 |
Massimine KM, McIntosh MT, Doan LT, Atreya CE, Gromer S, Sirawaraporn W, Elliott DA, Joiner KA, Schirmer RH, Anderson KS. Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 50: 3132-41. PMID 16940112 DOI: 10.1128/Aac.00621-06 |
0.363 |
|
| 2006 |
Thakur VV, Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Wang L, Anderson KS, Jorgensen WL. Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 5664-7. PMID 16931015 DOI: 10.1016/J.Bmcl.2006.08.037 |
0.497 |
|
| 2006 |
Basavapathruni A, Vingerhoets J, de Béthune MP, Chung R, Bailey CM, Kim J, Anderson KS. Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations. Biochemistry. 45: 7334-40. PMID 16752922 DOI: 10.1021/Bi052362V |
0.478 |
|
| 2006 |
Basavapathruni A, Anderson KS. Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly. Current Pharmaceutical Design. 12: 1857-65. PMID 16724952 DOI: 10.2174/138161206776873617 |
0.474 |
|
| 2006 |
Ruiz-Caro J, Basavapathruni A, Kim JT, Bailey CM, Wang L, Anderson KS, Hamilton AD, Jorgensen WL. Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 668-71. PMID 16298131 DOI: 10.1016/J.Bmcl.2005.10.037 |
0.504 |
|
| 2006 |
Jorgensen WL, Ruiz-Caro J, Tirado-Rives J, Basavapathruni A, Anderson KS, Hamilton AD. Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 663-7. PMID 16263277 DOI: 10.1016/J.Bmcl.2005.10.038 |
0.464 |
|
| 2005 |
Murakami E, Basavapathruni A, Bradley WD, Anderson KS. Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases. Antiviral Research. 67: 10-7. PMID 15950748 DOI: 10.1016/J.Antiviral.2004.12.004 |
0.502 |
|
| 2005 |
Ray AS, Hernandez-Santiago BI, Mathew JS, Murakami E, Bozeman C, Xie MY, Dutschman GE, Gullen E, Yang Z, Hurwitz S, Cheng YC, Chu CK, McClure H, Schinazi RF, Anderson KS. Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine. Antimicrobial Agents and Chemotherapy. 49: 1994-2001. PMID 15855524 DOI: 10.1128/AAC.49.5.1994-2001.2005 |
0.418 |
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| 2005 |
Anderson KS. Detection of novel enzyme intermediates in PEP-utilizing enzymes. Archives of Biochemistry and Biophysics. 433: 47-58. PMID 15581565 DOI: 10.1016/J.Abb.2004.10.016 |
0.304 |
|
| 2004 |
Feng JY, Murakami E, Zorca SM, Johnson AA, Johnson KA, Schinazi RF, Furman PA, Anderson KS. Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrobial Agents and Chemotherapy. 48: 1300-6. PMID 15047533 DOI: 10.1128/Aac.48.4.1300-1306.2004 |
0.42 |
|
| 2004 |
Murakami E, Ray AS, Schinazi RF, Anderson KS. Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP. Antiviral Research. 62: 57-64. PMID 15026203 DOI: 10.1016/J.Antiviral.2003.12.001 |
0.414 |
|
| 2004 |
Basavapathruni A, Bailey CM, Anderson KS. Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs. The Journal of Biological Chemistry. 279: 6221-4. PMID 14722107 DOI: 10.1074/Jbc.C300523200 |
0.458 |
|
| 2003 |
Ray AS, Schinazi RF, Murakami E, Basavapathruni A, Shi J, Zorca SM, Chu CK, Anderson KS. Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase. Antiviral Chemistry & Chemotherapy. 14: 115-25. PMID 14521328 DOI: 10.1177/095632020301400301 |
0.469 |
|
| 2003 |
Ray AS, Murakami E, Basavapathruni A, Vaccaro JA, Ulrich D, Chu CK, Schinazi RF, Anderson KS. Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis. Biochemistry. 42: 8831-41. PMID 12873144 DOI: 10.1021/Bi034435L |
0.487 |
|
| 2003 |
Jeffrey JL, Feng JY, Qi CCR, Anderson KS, Furman PA. Dioxolane guanosine 5′-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase: Steady state and pre-steady state kinetic analyses Journal of Biological Chemistry. 278: 18971-18979. PMID 12651859 DOI: 10.1074/jbc.M210113200 |
0.439 |
|
| 2003 |
Atreya CE, Johnson EF, Irwin JJ, Dow A, Massimine KM, Coppens I, Stempliuk V, Beverley S, Joiner KA, Shoichet BK, Anderson KS. A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase. The Journal of Biological Chemistry. 278: 14092-100. PMID 12556445 DOI: 10.1074/Jbc.M212690200 |
0.372 |
|
| 2002 |
Ray AS, Murakami E, Peterson CN, Shi J, Schinazi RF, Anderson KS. Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase. Antiviral Research. 56: 189-205. PMID 12406504 DOI: 10.1016/S0166-3542(02)00102-X |
0.407 |
|
| 2002 |
Johnson EF, Hinz W, Atreya CE, Maley F, Anderson KS. Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity. The Journal of Biological Chemistry. 277: 43126-36. PMID 12192007 DOI: 10.1074/Jbc.M206523200 |
0.324 |
|
| 2002 |
Ray AS, Basavapathruni A, Anderson KS. Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir. The Journal of Biological Chemistry. 277: 40479-90. PMID 12176989 DOI: 10.1074/Jbc.M205303200 |
0.43 |
|
| 2002 |
Anderson KS. Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase. Biochimica Et Biophysica Acta. 1587: 296-9. PMID 12084471 DOI: 10.1016/S0925-4439(02)00092-3 |
0.485 |
|
| 2002 |
Ray AS, Yang Z, Shi J, Hobbs A, Schinazi RF, Chu CK, Anderson KS. Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate. Biochemistry. 41: 5150-62. PMID 11955063 DOI: 10.1021/Bi0121858 |
0.551 |
|
| 2002 |
Bulock KG, Beardsley GP, Anderson KS. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. The Journal of Biological Chemistry. 277: 22168-74. PMID 11948179 DOI: 10.1074/Jbc.M111964200 |
0.304 |
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| 2002 |
Ray AS, Yang Z, Chu CK, Anderson KS. Novel use of a guanosine prodrug approach to convert 2',3'-didehydro-2',3'-dideoxyguanosine into a viable antiviral agent. Antimicrobial Agents and Chemotherapy. 46: 887-91. PMID 11850281 DOI: 10.1128/Aac.46.3.887-891.2002 |
0.472 |
|
| 2002 |
Ray AS, Anderson KS. Mechanistic studies to understand the inhibition of wild type and mutant HIV-1 reverse transcriptase by Carbovir-triphosphate. Nucleosides, Nucleotides & Nucleic Acids. 20: 1247-50. PMID 11562995 DOI: 10.1081/NCN-100002528 |
0.396 |
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| 2002 |
Painter G, Anderson K, Bouygues M, Joubert M, Liotta D. Virally Encoded Polymerases as Targets for Chemotherapy: Application to HIV and HBV Current Medicinal Chemistry -Anti-Infective Agents. 1: 99-117. DOI: 10.2174/1568012023354974 |
0.311 |
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| 2001 |
Krynetskaia NF, Feng JY, Krynetski EY, Garcia JV, Panetta JC, Anderson KS, Evans WE. Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1902-8. PMID 11532970 DOI: 10.1096/fj.01-0124com |
0.383 |
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| 2000 |
Furman PA, Painter GR, Anderson KS. An analysis of the catalytic cycle of HIV-1 reverse transcriptase: opportunities for chemotherapeutic intervention based on enzyme inhibition. Current Pharmaceutical Design. 6: 547-67. PMID 10788596 DOI: 10.2174/1381612003400777 |
0.376 |
|
| 2000 |
Vaccaro JA, Parnell KM, Terezakis SA, Anderson KS. Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP. Antimicrobial Agents and Chemotherapy. 44: 217-21. PMID 10602755 |
0.429 |
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| 1999 |
Feng JY, Shi J, Schinazi RF, Anderson KS. Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1511-7. PMID 10463941 DOI: 10.1096/fasebj.13.12.1511 |
0.388 |
|
| 1999 |
Feng JY, Anderson KS. Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase. Biochemistry. 38: 9440-8. PMID 10413520 DOI: 10.1021/BI990709M |
0.371 |
|
| 1999 |
Feng JY, Anderson KS. Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase. Biochemistry. 38: 55-63. PMID 9890882 DOI: 10.1021/BI982340R |
0.412 |
|
| 1998 |
Vaccaro JA, Anderson KS. Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance. Biochemistry. 37: 14189-94. PMID 9760256 DOI: 10.1021/bi9810353 |
0.34 |
|
| 1997 |
Kerr SG, Anderson KS. Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance. Biochemistry. 36: 14064-70. PMID 9369478 DOI: 10.1021/BI9713862 |
0.311 |
|
| 1996 |
Spence RA, Anderson KS, Johnson KA. HIV-1 Reverse transcriptase resistance to nonnucleoside inhibitors Biochemistry. 35: 1054-1063. PMID 8547241 DOI: 10.1021/Bi952058+ |
0.301 |
|
| 1995 |
Spence RA, Kati WM, Anderson KS, Johnson KA. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors Science. 267: 988-993. PMID 7532321 DOI: 10.1126/Science.7532321 |
0.395 |
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