| Year |
Citation |
Score |
| 2023 |
Ghovanloo MR, Arnold JC, Ruben PC. Editorial: Cannabinoid interactions with ion channels, receptors, and the bio-membrane. Frontiers in Physiology. 14: 1211230. PMID 37228821 DOI: 10.3389/fphys.2023.1211230 |
0.751 |
|
| 2022 |
Ghovanloo MR, Dib-Hajj SD, Goodchild SJ, Ruben PC, Waxman SG. Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol. Frontiers in Physiology. 13: 1066455. PMID 36439273 DOI: 10.3389/fphys.2022.1066455 |
0.823 |
|
| 2022 |
Abdelsayed M, Page D, Ruben PC. : A novel class of potential antiarrhythmic compounds. Frontiers in Pharmacology. 13: 976903. PMID 36249789 DOI: 10.3389/fphar.2022.976903 |
0.33 |
|
| 2022 |
Ghovanloo MR, Goodchild SJ, Ruben PC. Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study. Plos One. 17: e0271801. PMID 35913948 DOI: 10.1371/journal.pone.0271801 |
0.747 |
|
| 2022 |
Fouda MA, Ghovanloo MR, Ruben PC. Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes. The Journal of Physiology. PMID 35436004 DOI: 10.1113/JP282768 |
0.802 |
|
| 2021 |
Jones LB, Peters CH, Rosch RE, Owers M, Hughes E, Pal DK, Ruben PC. The L1624Q Variant in Causes Familial Epilepsy Through a Mixed Gain and Loss of Channel Function. Frontiers in Pharmacology. 12: 788192. PMID 34925043 DOI: 10.3389/fphar.2021.788192 |
0.768 |
|
| 2021 |
Gorman KM, Peters CH, Lynch B, Jones L, Bassett DS, King MD, Ruben PC, Rosch RE. Persistent sodium currents in developmental and degenerative epileptic dyskinetic encephalopathy. Brain Communications. 3: fcab235. PMID 34755109 DOI: 10.1093/braincomms/fcab235 |
0.757 |
|
| 2021 |
Ghovanloo MR, Ruben PC. Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10738584211017009. PMID 34027742 DOI: 10.1177/10738584211017009 |
0.825 |
|
| 2021 |
Ghovanloo MR, Choudhury K, Bandaru TS, Fouda MA, Rayani K, Rusinova R, Phaterpekar T, Nelkenbrecher K, Watkins AR, Poburko D, Thewalt J, Andersen OS, Delemotte L, Goodchild SJ, Ruben PC. Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity. The Journal of General Physiology. 153. PMID 33836525 DOI: 10.1085/jgp.202012701 |
0.745 |
|
| 2020 |
Ghovanloo MR, Atallah J, Escudero CA, Ruben PC. Biophysical Characterization of a Novel Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death. Frontiers in Physiology. 11: 610436. PMID 33414724 DOI: 10.3389/fphys.2020.610436 |
0.725 |
|
| 2020 |
Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace BA. Cannabidiol interactions with voltage-gated sodium channels. Elife. 9. PMID 33089780 DOI: 10.7554/eLife.58593 |
0.825 |
|
| 2020 |
Peters CH, Watkins AR, Poirier OL, Ruben PC. E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms. The Journal of General Physiology. 152. PMID 32569350 DOI: 10.1085/jgp.202012595 |
0.816 |
|
| 2020 |
Ghovanloo MR, Ruben PC. Say Cheese: Structure of the Cardiac Electrical Engine Is Captured. Trends in Biochemical Sciences. 45: 369-371. PMID 32311330 DOI: 10.1016/J.Tibs.2020.02.003 |
0.807 |
|
| 2020 |
Fouda MA, Ghovanloo MR, Ruben PC. Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels. British Journal of Pharmacology. PMID 32077098 DOI: 10.1111/Bph.15020 |
0.756 |
|
| 2020 |
Angus M, Ruben P. Voltage gated sodium channels in cancer and their potential mechanisms of action. Channels (Austin, Tex.). 13: 400-409. PMID 31510893 DOI: 10.1080/19336950.2019.1666455 |
0.454 |
|
| 2020 |
Fouda MA, Ghovanloo M, Ruben PC. Protective Effect of Cannabidiol Against Oxidative Stress and Cytotoxicity Evoked by High Glucose in Cardiac Voltage-Gated Sodium Channels Biophysical Journal. 118: 578a. DOI: 10.1016/J.Bpj.2019.11.3138 |
0.793 |
|
| 2020 |
Goodchild SJ, Ghovanloo M, Williams A, Shuart N, Soriano M, Mezeyova J, Dean R, Focken T, Ruben P, Empfield J, Cohen C, Johnson J. Targeting of NAV1.6 and NAV1.2 to Inhibit Excitatory vs Inhibitory Neural Circuits Biophysical Journal. 118: 499a-500a. DOI: 10.1016/J.Bpj.2019.11.2758 |
0.701 |
|
| 2020 |
Ghovanloo M, Sanketh Bandaru T, Choudhury K, Fouda M, Rayani K, Poburko D, Delemotte L, Ruben PC. Mechanism of Sodium Channel Inhibition by Cannabidiol Biophysical Journal. 118: 499a. DOI: 10.1016/J.Bpj.2019.11.2757 |
0.815 |
|
| 2019 |
Rosch R, Burrows DRW, Jones LB, Peters CH, Ruben P, Samarut É. Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks. Frontiers in Cellular Neuroscience. 13: 556. PMID 31920556 DOI: 10.3389/Fncel.2019.00556 |
0.703 |
|
| 2019 |
Angus M, Peters CH, Poburko D, Brimble E, Spelbrink EM, Ruben PC. Case Studies in Neuroscience: A Novel Amino Acid Duplication in the N-terminus of the Brain Sodium Channel Na1.1 Underlying Dravet Syndrome. Journal of Neurophysiology. PMID 31533007 DOI: 10.1152/jn.00491.2019 |
0.783 |
|
| 2018 |
Ghovanloo MR, Peters CH, Ruben PC. Effects of Acidosis on Neuronal Voltage-Gated Sodium Channels: Nav1.1 and Nav1.3. Channels (Austin, Tex.). PMID 30362397 DOI: 10.1080/19336950.2018.1539611 |
0.866 |
|
| 2018 |
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. The Journal of Biological Chemistry. PMID 30219789 DOI: 10.1074/Jbc.Ra118.004929 |
0.842 |
|
| 2018 |
Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports. 8: 6304. PMID 29674667 DOI: 10.1038/S41598-018-24719-Y |
0.824 |
|
| 2018 |
Abdelsayed M, Ruprai M, Ruben PC. The efficacy of Ranolazine on E1784K is altered by temperature and calcium. Scientific Reports. 8: 3643. PMID 29483621 DOI: 10.1038/s41598-018-22033-1 |
0.5 |
|
| 2018 |
Peters CH, Ghovanloo MR, Gershome C, Ruben PC. pH Modulation of Voltage-Gated Sodium Channels. Handbook of Experimental Pharmacology. PMID 29460150 DOI: 10.1007/164_2018_99 |
0.861 |
|
| 2018 |
Ghovanloo M, Gregory Shuart N, Mezeyova J, Ruben PC, Goodchild SJ. Effects of Cannabidiol on Human Nav Channels Biophysical Journal. 114: 636a. DOI: 10.1016/J.Bpj.2017.11.3437 |
0.809 |
|
| 2017 |
Abdelsayed M, Peters CH, Ruben PC. Arrhythmogenic Triggers Associated with Sudden Cardiac Death. Channels (Austin, Tex.). 0. PMID 28976236 DOI: 10.1080/19336950.2017.1388057 |
0.667 |
|
| 2017 |
Thibodeau ML, Peters CH, Townsend KN, Shen Y, Hendson G, Adam S, Selby K, Macleod PM, Gershome C, Ruben P, Jones SJM, Friedman JM, Gibson WT, Horvath GA. Compound heterozygous TRPV4 mutations in two siblings with a complex phenotype including severe intellectual disability and neuropathy. American Journal of Medical Genetics. Part A. PMID 28898540 DOI: 10.1002/ajmg.a.38400 |
0.729 |
|
| 2017 |
Peters CH, Yu A, Zhu W, Silva JR, Ruben PC. Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation. Plos One. 12: e0184605. PMID 28898267 DOI: 10.1371/Journal.Pone.0184605 |
0.824 |
|
| 2017 |
Abdelsayed M, Baruteau AE, Gibbs K, Sanatani S, Krahn AD, Probst V, Ruben PC. Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants. The Journal of Physiology. PMID 28734073 DOI: 10.1113/JP274536 |
0.4 |
|
| 2017 |
Abdelsayed M, Peters C, Ruben P. PHYSIOLOGICAL TRIGGERS EXACERBATE THE ARRHYTHMOGENICITY OF THE NAV1.5 MUTANT, E1784K Canadian Journal of Cardiology. 33: S47-S48. DOI: 10.1016/j.cjca.2017.07.113 |
0.672 |
|
| 2017 |
Ghovanloo M, Ruben PC. Mixed Periodic Paralysis & Myotonia Mutant Imparts pH Sensitivity in NaV1.4 Biophysical Journal. 112: 241a. DOI: 10.1016/J.Bpj.2016.11.1319 |
0.8 |
|
| 2016 |
Ghovanloo MR, Aimar K, Ghadiry-Tavi R, Yu A, Ruben PC. Physiology and Pathophysiology of Sodium Channel Inactivation. Current Topics in Membranes. 78: 479-509. PMID 27586293 DOI: 10.1016/bs.ctm.2016.04.001 |
0.839 |
|
| 2016 |
Peters C, Rosch RE, Hughes E, Ruben PC. Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures. Scientific Reports. 6: 31879. PMID 27582020 DOI: 10.1038/Srep31879 |
0.772 |
|
| 2016 |
Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Frontiers in Pharmacology. 7: 39. PMID 26973526 DOI: 10.3389/Fphar.2016.00039 |
0.751 |
|
| 2016 |
Ghovanloo M, Ruben PC. The Effects of Amiodarone and N-Desethylamiodarone on Cardiac Voltage-Gated Sodium Channels Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.663 |
0.781 |
|
| 2016 |
Abdelsayed M, Ruben PC. Intracellular Calcium Differentially affects SCN5A Mixed Syndrome Mutations Biophysical Journal. 110: 109a. DOI: 10.1016/j.bpj.2015.11.645 |
0.324 |
|
| 2015 |
Peters CH, Abdelsayed M, Ruben PC. Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes. Progress in Biophysics and Molecular Biology. PMID 26713557 DOI: 10.1016/j.pbiomolbio.2015.12.009 |
0.795 |
|
| 2015 |
Zaharieva IT, Thor MG, Oates EC, van Karnebeek C, Hendson G, Blom E, Witting N, Rasmussen M, Gabbett MT, Ravenscroft G, Sframeli M, Suetterlin K, Sarkozy A, D'Argenzio L, Hartley L, ... ... Ruben P, et al. Loss-of-function mutations in SCN4A cause severe foetal hypokinesia or 'classical' congenital myopathy. Brain : a Journal of Neurology. PMID 26700687 DOI: 10.1093/Brain/Awv352 |
0.451 |
|
| 2015 |
Abdelsayed M, Peters CH, Ruben PC. Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants. The Journal of Physiology. 593: 4201-23. PMID 26131924 DOI: 10.1113/JP270139 |
0.805 |
|
| 2015 |
van Karnebeek CD, Ye X, Abdelsayed M, Selby K, Zhang L, Chijiwa C, Hendson G, Sayson B, Gill H, Balicki M, Eydoux P, Ross CJ, Vallance H, Wasserman W, Ruben P, et al. MG-115 Compound heterozygous SCN4A mutation underlies severe congenital hypotonia and biophysical alteration in the encoded voltage-gated NAV1.4 sodium channel Journal of Medical Genetics. 52: A3.2-A4. DOI: 10.1136/jmedgenet-2015-103577.8 |
0.499 |
|
| 2015 |
Zhao Y, Peters CH, Ruben PC, Robertson GA. Homologous Domains Mediate Distinct Gating Functions in EAG vs. Cyclic-Nucleotide Gated Channels Biophysical Journal. 108: 276a-277a. DOI: 10.1016/J.Bpj.2014.11.1515 |
0.841 |
|
| 2014 |
Jones DK, Ruben PC. Proton modulation of cardiac I Na: a potential arrhythmogenic trigger. Handbook of Experimental Pharmacology. 221: 169-81. PMID 24737236 DOI: 10.1007/978-3-642-41588-3_8 |
0.643 |
|
| 2014 |
Peters CH, Ruben PC. Introduction to sodium channels. Handbook of Experimental Pharmacology. 221: 1-6. PMID 24737229 DOI: 10.1007/978-3-642-41588-3_1 |
0.813 |
|
| 2014 |
Abdelsayed M, Ruben PC. Differential Thermosensitivity in Nav1.5 Mutations Associated with Long QT and Brugada Syndromes Biophysical Journal. 106: 327a-328a. DOI: 10.1016/j.bpj.2013.11.1883 |
0.41 |
|
| 2014 |
Peters CH, Ruben PC. Acidosis: A Possible Trigger for Brugada Syndrome Associated Arrhythmia Biophysical Journal. 106: 327a. DOI: 10.1016/J.BPJ.2013.11.1880 |
0.804 |
|
| 2013 |
Abdelsayed M, Sokolov S, Ruben PC. A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV1.2. Frontiers in Pharmacology. 4: 121. PMID 24065921 DOI: 10.3389/fphar.2013.00121 |
0.489 |
|
| 2013 |
Jones DK, Claydon TW, Ruben PC. Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel. Biophysical Journal. 105: 101-7. PMID 23823228 DOI: 10.1016/J.Bpj.2013.04.022 |
0.791 |
|
| 2013 |
Sokolov S, Peters CH, Rajamani S, Ruben PC. Proton-dependent inhibition of the cardiac sodium channel Nav1.5 by ranolazine. Frontiers in Pharmacology. 4: 78. PMID 23801963 DOI: 10.3389/fphar.2013.00078 |
0.828 |
|
| 2013 |
Peters CH, Sokolov S, Rajamani S, Ruben PC. Effects of the antianginal drug, ranolazine, on the brain sodium channel Na(V)1.2 and its modulation by extracellular protons. British Journal of Pharmacology. 169: 704-16. PMID 23472826 DOI: 10.1111/bph.12150 |
0.81 |
|
| 2013 |
Jones DK, Peters CH, Allard CR, Claydon TW, Ruben PC. Proton sensors in the pore domain of the cardiac voltage-gated sodium channel. The Journal of Biological Chemistry. 288: 4782-91. PMID 23283979 DOI: 10.1074/Jbc.M112.434266 |
0.859 |
|
| 2013 |
Peters CH, Sokolov S, Rajamani S, Ruben PC. Proton Modulation of Ranolazine Effects on Slow Inactivation in Sodium Channels Biophysical Journal. 104: 133a-134a. DOI: 10.1016/j.bpj.2012.11.763 |
0.827 |
|
| 2012 |
Vilin YY, Peters CH, Ruben PC. Acidosis differentially modulates inactivation in na(v)1.2, na(v)1.4, and na(v)1.5 channels. Frontiers in Pharmacology. 3: 109. PMID 22701426 DOI: 10.3389/fphar.2012.00109 |
0.797 |
|
| 2012 |
Egri C, Ruben PC. A hot topic: temperature sensitive sodium channelopathies. Channels (Austin, Tex.). 6: 75-85. PMID 22643347 DOI: 10.4161/chan.19827 |
0.439 |
|
| 2012 |
Egri C, Vilin YY, Ruben PC. A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation. Epilepsia. 53: 494-505. PMID 22292491 DOI: 10.1111/j.1528-1167.2011.03389.x |
0.542 |
|
| 2012 |
Jones DK, Claydon T, Ruben PC. Proton Modulation of Gating Currents in the Cardiac Voltage-Gated Sodium Channel, NaV1.5 Biophysical Journal. 102: 326a-327a. DOI: 10.1016/J.Bpj.2011.11.1790 |
0.799 |
|
| 2012 |
Peters CH, Rajamani S, Ruben PC. Ranolazine Effects on NaV1.2 and Modulation by pH Biophysical Journal. 102: 323a-324a. DOI: 10.1016/j.bpj.2011.11.1775 |
0.78 |
|
| 2011 |
Jones DK, Peters CH, Tolhurst SA, Claydon TW, Ruben PC. Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5. Biophysical Journal. 101: 2147-56. PMID 22067152 DOI: 10.1016/J.Bpj.2011.08.056 |
0.856 |
|
| 2011 |
Lee CH, Jones DK, Ahern C, Sarhan MF, Ruben PC. Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 197: 33-43. PMID 20820785 DOI: 10.1007/S00359-010-0582-9 |
0.579 |
|
| 2011 |
Egri C, Vilin YY, Ruben PC. C121W Implicated in GEFS+ is a Thermosensitive Sodium Channel Mutation Biophysical Journal. 100: 423a. DOI: 10.1016/j.bpj.2010.12.2506 |
0.461 |
|
| 2011 |
Jones DK, Claydon TW, Ruben PC. Turret Histidines in pH Modulation of the Cardiac Voltage-Gated Sodium Channel Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2496 |
0.82 |
|
| 2010 |
Vilin YY, Ruben PC. Differential pH-Dependent Regulation of NaV Channels Biophysical Journal. 98: 111a. DOI: 10.1016/J.BPJ.2009.12.4196 |
0.505 |
|
| 2010 |
Jones DK, Claydon TW, Ruben PC. pH Modulation of the Cardiac Voltage Gated Sodium Channel, Nav1.5 Biophysical Journal. 98: 111a. DOI: 10.1016/J.Bpj.2009.12.4195 |
0.764 |
|
| 2010 |
Lee CH, Jones DK, Ahern C, Sarhan MF, Ruben PC. The Biophysical Costs Associated With Tetrodotoxin Resistance in the Garter Snake, Thamnophis Sirtalis Biophysical Journal. 98: 8a. DOI: 10.1016/J.Bpj.2009.12.047 |
0.654 |
|
| 2009 |
Vilin Y, Ruben PC. pH-Dependent Regulation of rNaV1.2 Channel Inactivation Biophysical Journal. 96: 251a. DOI: 10.1016/J.BPJ.2008.12.1240 |
0.551 |
|
| 2008 |
Lee CH, Ruben PC. Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Channels (Austin, Tex.). 2: 407-12. PMID 19098433 DOI: 10.4161/chan.2.6.7429 |
0.561 |
|
| 2008 |
Jones DK, Ruben PC. Biophysical defects in voltage.gated sodium channels associated with long QT and Brugada syndromes. Channels (Austin, Tex.). 2: 70-80. PMID 18849657 DOI: 10.4161/Chan.2.2.6000 |
0.72 |
|
| 2008 |
Sun H, Varela D, Chartier D, Ruben PC, Nattel S, Zamponi GW, Leblanc N. Differential interactions of Na+ channel toxins with T-type Ca2+ channels. The Journal of General Physiology. 132: 101-13. PMID 18591418 DOI: 10.1085/Jgp.200709883 |
0.43 |
|
| 2008 |
Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ. Action potential generation requires a high sodium channel density in the axon initial segment. Nature Neuroscience. 11: 178-86. PMID 18204443 DOI: 10.1038/nn2040 |
0.551 |
|
| 2007 |
Groome JR, Dice MC, Fujimoto E, Ruben PC. Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linker. Biophysical Journal. 93: 1519-33. PMID 17513361 DOI: 10.1529/biophysj.106.102079 |
0.728 |
|
| 2006 |
Dice MS, Kearl T, Ruben PC. Methods for studying voltage-gated sodium channels in heterologous expression systems. Methods in Molecular Medicine. 129: 163-85. PMID 17085811 DOI: 10.1385/1-59745-213-0:163 |
0.575 |
|
| 2006 |
Salvador-Recatalà V, Gallin WJ, Abbruzzese J, Ruben PC, Spencer AN. A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit. The Journal of Experimental Biology. 209: 731-47. PMID 16449567 DOI: 10.1242/jeb.02032 |
0.572 |
|
| 2006 |
Geffeney SL, Ruben PC. The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels Marine Drugs. 4: 143-156. DOI: 10.3390/Md403143 |
0.859 |
|
| 2005 |
Groome JR, Fujimoto E, Ruben PC. K-aggravated myotonia mutations at residue G1306 differentially alter deactivation gating of human skeletal muscle sodium channels. Cellular and Molecular Neurobiology. 25: 1075-92. PMID 16392038 DOI: 10.1007/s10571-005-8057-1 |
0.716 |
|
| 2005 |
Geffeney SL, Fujimoto E, Brodie ED, Brodie ED, Ruben PC. Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. Nature. 434: 759-63. PMID 15815629 DOI: 10.1038/Nature03444 |
0.815 |
|
| 2004 |
Dice MS, Abbruzzese JL, Wheeler JT, Groome JR, Fujimoto E, Ruben PC. Temperature-sensitive defects in paramyotonia congenita mutants R1448C and T1313M. Muscle & Nerve. 30: 277-88. PMID 15318338 DOI: 10.1002/Mus.20080 |
0.76 |
|
| 2003 |
Locher CP, Ruben PC, Gut J, Rosenthal PJ. 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Antimicrobial Agents and Chemotherapy. 47: 3806-9. PMID 14638487 DOI: 10.1128/AAC.47.12.3806-3809.2003 |
0.337 |
|
| 2003 |
McCollum IJ, Vilin YY, Spackman E, Fujimoto E, Ruben PC. Negatively charged residues adjacent to IFM motif in the DIII-DIV linker of hNa(V)1.4 differentially affect slow inactivation. Febs Letters. 552: 163-9. PMID 14527681 DOI: 10.1016/S0014-5793(03)00912-8 |
0.34 |
|
| 2003 |
Groome JR, Fujimoto E, Ruben PC. Negative charges in the DIII-DIV linker of human skeletal muscle Na+ channels regulate deactivation gating. The Journal of Physiology. 548: 85-96. PMID 12588896 DOI: 10.1113/jphysiol.2002.033084 |
0.718 |
|
| 2002 |
Geffeney S, Brodie ED, Ruben PC, Brodie ED. Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels. Science (New York, N.Y.). 297: 1336-9. PMID 12193784 DOI: 10.1126/Science.1074310 |
0.794 |
|
| 2002 |
Groome J, Fujimoto E, Walter L, Ruben P. Outer and central charged residues in DIVS4 of skeletal muscle sodium channels have differing roles in deactivation. Biophysical Journal. 82: 1293-307. PMID 11867446 DOI: 10.1016/S0006-3495(02)75485-4 |
0.657 |
|
| 2001 |
Vilin YY, Ruben PC. Slow inactivation in voltage-gated sodium channels: molecular substrates and contributions to channelopathies. Cell Biochemistry and Biophysics. 35: 171-90. PMID 11892790 DOI: 10.1385/CBB:35:2:171 |
0.605 |
|
| 2001 |
Vilin YY, Fujimoto E, Ruben PC. A novel mechanism associated with idiopathic ventricular fibrillation (IVF) mutations R1232W and T1620M in human cardiac sodium channels. Pflã¼Gers Archiv : European Journal of Physiology. 442: 204-11. PMID 11417215 DOI: 10.1007/s004240100529 |
0.602 |
|
| 2001 |
Vilin YY, Fujimoto E, Ruben PC. A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation. Biophysical Journal. 80: 2221-30. PMID 11325725 DOI: 10.1016/S0006-3495(01)76195-4 |
0.559 |
|
| 2000 |
Groome JR, Fujimoto E, Ruben PC. The delay in recovery from fast inactivation in skeletal muscle sodium channels is deactivation. Cellular and Molecular Neurobiology. 20: 521-7. PMID 10901271 DOI: 10.1023/A:1007040731407 |
0.719 |
|
| 1999 |
Vilin YY, Makita N, George AL, Ruben PC. Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels. Biophysical Journal. 77: 1384-93. PMID 10465750 DOI: 10.1016/S0006-3495(99)76987-0 |
0.567 |
|
| 1999 |
Wang DW, VanDeCarr D, Ruben PC, George AL, Bennett PB. Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia. Febs Letters. 448: 231-4. PMID 10218481 DOI: 10.1016/S0014-5793(99)00338-5 |
0.62 |
|
| 1999 |
Groome JR, Fujimoto E, George AL, Ruben PC. Differential effects of homologous S4 mutations in human skeletal muscle sodium channels on deactivation gating from open and inactivated states. The Journal of Physiology. 516: 687-98. PMID 10200418 DOI: 10.1111/j.1469-7793.1999.0687u.x |
0.717 |
|
| 1999 |
Cha A, Ruben PC, George AL, Fujimoto E, Bezanilla F. Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation. Neuron. 22: 73-87. PMID 10027291 DOI: 10.1016/S0896-6273(00)80680-7 |
0.389 |
|
| 1998 |
Richmond JE, Featherstone DE, Hartmann HA, Ruben PC. Slow inactivation in human cardiac sodium channels. Biophysical Journal. 74: 2945-52. PMID 9635748 DOI: 10.1016/S0006-3495(98)78001-4 |
0.825 |
|
| 1998 |
Featherstone DE, Fujimoto E, Ruben PC. A defect in skeletal muscle sodium channel deactivation exacerbates hyperexcitability in human paramyotonia congenita. The Journal of Physiology. 506: 627-38. PMID 9503326 DOI: 10.1111/j.1469-7793.1998.627bv.x |
0.718 |
|
| 1997 |
Richmond JE, VanDeCarr D, Featherstone DE, George AL, Ruben PC. Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutant. Biophysical Journal. 73: 1896-903. PMID 9336185 DOI: 10.1016/S0006-3495(97)78220-1 |
0.801 |
|
| 1997 |
Ruben PC, Fleig A, Featherstone D, Starkus JG, Rayner MD. Effects of clamp rise-time on rat brain IIA sodium channels in Xenopus oocytes. Journal of Neuroscience Methods. 73: 113-22. PMID 9196281 DOI: 10.1016/S0165-0270(96)02216-9 |
0.848 |
|
| 1997 |
Richmond JE, Featherstone DE, Ruben PC. Human Na+ channel fast and slow inactivation in paramyotonia congenita mutants expressed in Xenopus laevis oocytes. The Journal of Physiology. 499: 589-600. PMID 9130156 DOI: 10.1113/jphysiol.1997.sp021952 |
0.803 |
|
| 1996 |
Featherstone DE, Richmond JE, Ruben PC. Interaction between fast and slow inactivation in Skm1 sodium channels. Biophysical Journal. 71: 3098-109. PMID 8968581 DOI: 10.1016/S0006-3495(96)79504-8 |
0.828 |
|
| 1994 |
Fleig A, Fitch JM, Goldin AL, Rayner MD, Starkus JG, Ruben PC. Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches. Pflã¼Gers Archiv : European Journal of Physiology. 427: 406-13. PMID 7971139 DOI: 10.1007/Bf00374254 |
0.844 |
|
| 1994 |
Fleig A, Ruben PC, Rayner MD. Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches. Pflã¼Gers Archiv : European Journal of Physiology. 427: 399-405. PMID 7971138 DOI: 10.1007/BF00374253 |
0.798 |
|
| 1993 |
Starkus JG, Rayner MD, Fleig A, Ruben PC. Fast and slow inactivation of sodium channels: effects of photodynamic modification by methylene blue. Biophysical Journal. 65: 715-26. PMID 8218899 DOI: 10.1016/S0006-3495(93)81098-1 |
0.821 |
|
| 1992 |
Ruben PC, Starkus JG, Rayner MD. Steady-state availability of sodium channels. Interactions between activation and slow inactivation. Biophysical Journal. 61: 941-55. PMID 1316183 DOI: 10.1016/S0006-3495(92)81901-X |
0.849 |
|
| 1992 |
Rayner MD, Starkus JG, Ruben PC, Alicata DA. Voltage-sensitive and solvent-sensitive processes in ion channel gating. Kinetic effects of hyperosmolar media on activation and deactivation of sodium channels. Biophysical Journal. 61: 96-108. PMID 1311613 DOI: 10.1016/S0006-3495(92)81819-2 |
0.851 |
|
| 1990 |
Ruben PC, Starkus JG, Rayner MD. Holding potential affects the apparent voltage-sensitivity of sodium channel activation in crayfish giant axons. Biophysical Journal. 58: 1169-81. PMID 1963328 DOI: 10.1016/S0006-3495(90)82458-9 |
0.84 |
|
| 1990 |
Stuenkel EL, Ruben P, Cooke IM, Lemos JR. Sodium-activated cation channels in peptidergic nerve terminals. Brain Research. 517: 35-43. PMID 1695866 DOI: 10.1016/0006-8993(90)91004-Z |
0.795 |
|
| 1989 |
Cooke I, Graf R, Grau S, Haylett B, Meyers D, Ruben P. Crustacean peptidergic neurons in culture show immediate outgrowth in simple medium. Proceedings of the National Academy of Sciences of the United States of America. 86: 402-6. PMID 2643105 DOI: 10.1073/Pnas.86.1.402 |
0.524 |
|
| 1988 |
Thompson S, Ruben P. Inward rectification in response to FMRFamide in Aplysia neuron L2: summation with transient K current The Journal of Neuroscience. 8: 3200-3207. DOI: 10.1523/JNEUROSCI.08-09-03200.1988 |
0.521 |
|
| 1984 |
Ruben P, Thompson S. Rapid recovery from K current inactivation on membrane hyperpolarization in molluscan neurons Journal of General Physiology. 84: 861-875. PMID 6097637 DOI: 10.1085/JGP.84.6.861 |
0.654 |
|
| 1983 |
Ruben P, Lukowiak K. Modulation of the Aplysia gill withdrawal reflex by dopamine. Journal of Neurobiology. 14: 271-84. PMID 6310047 DOI: 10.1002/neu.480140403 |
0.415 |
|
| 1982 |
Ruben P, Lukowiak K. Habituation and dishabituation in isolated gill pinnules in Aplysia Comparative Biochemistry and Physiology Part a: Physiology. 71: 585-589. DOI: 10.1016/0300-9629(82)90207-9 |
0.404 |
|
| 1981 |
Ruben P, Goldberg J, Edstrom J, Voshart K, Lukowiak K. Viewpoint. What the marine mollusc Aplysia can tell the neurologist about behavioral neurophysiology. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 8: 275-80. PMID 7326606 DOI: 10.1017/S0317167100043389 |
0.509 |
|
| 1979 |
Ruben P, Lukowiak K. Dopamine modulation of gill reflex behavior in Aplysia. Canadian Journal of Physiology and Pharmacology. 57: 329-32. PMID 445234 DOI: 10.1139/Y79-051 |
0.408 |
|
| 1979 |
Ruben PC, Swann JW, Carpenter DO. Neurotransmitter receptors on gill muscle fibers and the gill peripheral nerve plexus in Aplysia. Canadian Journal of Physiology and Pharmacology. 57: 1088-97. PMID 41632 DOI: 10.1139/Y79-163 |
0.355 |
|
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