Yasuo Ihara, MD - Related publications

Affiliations: 
Neuropathology University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=59
Website:
http://books.google.com/books?id=QPqCvP0wFjUC&pg=PA209&lpg=PA209&dq=Yasuo+Ihara+tokyo&source=bl&ots=pitZ1PpZ6j&sig=DXK34KdhupZLLkBcCLSrRVGltd8&hl=en&ei=5XNCTfX4HcP78Aai0cyLAg&sa=X&oi=
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Jepsen WM, De Both M, Siniard AL, Ramsey K, Piras IS, Naymik M, Henderson A, Huentelman MJ. Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, . Biology Open. PMID 32878879 DOI: 10.1242/bio.054627   
2020 Chakraborty S, ThimmaReddygari J, Selvaraj D. G-lymphatic, vascular and immune pathways for Aβ clearance cascade and therapeutic targets for Alzheimer's disease. Combinatorial Chemistry & High Throughput Screening. PMID 32875981 DOI: 10.2174/1386207323666200901095003   
2020 Yeung CHC, Lau KWD, Au Yeung SL, Schooling CM. Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. European Journal of Epidemiology. PMID 32929646 DOI: 10.1007/s10654-020-00683-8   
2020 Ray WJ, Buggia-Prevot V. Novel Targets for Alzheimer's Disease: A View Beyond Amyloid. Annual Review of Medicine. PMID 32867590 DOI: 10.1146/annurev-med-052919-120219   
2020 Wang HF, Shen XN, Li JQ, Suckling J, Tan CC, Wang YJ, Feng L, Zhang C, Tan L, Dong Q, Touchon J, Gauthier S, Yu JT, . Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12095. PMID 32793801 DOI: 10.1002/dad2.12095   
2020 Dinkel F, Trujillo-Rodriguez D, Villegas A, Streffer J, Mercken M, Lopera F, Glatzel M, Sepulveda-Falla D. Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer's Disease Patients. Frontiers in Aging Neuroscience. 12: 220. PMID 32848702 DOI: 10.3389/fnagi.2020.00220   
2020 Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1. Molecular Neurodegeneration. 15: 53. PMID 32921309 DOI: 10.1186/s13024-020-00393-5   
2020 Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. A pentacyclic triterpene from targets γ-secretase. Acs Chemical Neuroscience. PMID 32786303 DOI: 10.1021/acschemneuro.0c00389   
2020 Hirschstein Z, Vanga GR, Wang G, Novakovic ZM, Grasso P. MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus. Biochimica Et Biophysica Acta. General Subjects. 129697. PMID 32738275 DOI: 10.1016/j.bbagen.2020.129697   
2020 Horie K, Barthélemy NR, Mallipeddi N, Li Y, Franklin EE, Perrin RJ, Bateman RJ, Sato C. Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain. Acta Neuropathologica Communications. 8: 149. PMID 32854776 DOI: 10.1186/s40478-020-01019-z   
2020 Kang SS, Ahn EH, Ye K. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & Molecular Medicine. PMID 32859953 DOI: 10.1038/s12276-020-00494-7   
2020 Keleman A, Wisch JK, Bollinger RM, Grant EA, Benzinger TL, Morris JC, Ances BM, Stark SL. Falls Associate with Neurodegenerative Changes in ATN Framework of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32741815 DOI: 10.3233/JAD-200192   
2020 Saddiki H, Fayosse A, Cognat E, Sabia S, Engelborghs S, Wallon D, Alexopoulos P, Blennow K, Zetterberg H, Parnetti L, Zerr I, Hermann P, Gabelle A, Boada M, Orellana A, ... , et al. Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. Plos Medicine. 17: e1003289. PMID 32817639 DOI: 10.1371/journal.pmed.1003289   
2020 von Saucken VE, Jay TR, Landreth GE. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105072. PMID 32890775 DOI: 10.1016/j.nbd.2020.105072   
2020 Zhao J, Liu X, Xia W, Zhang Y, Wang C. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Frontiers in Molecular Neuroscience. 13: 137. PMID 32848600 DOI: 10.3389/fnmol.2020.00137   
2020 De La-Rocque S, Moretto E, Butnaru I, Schiavo G. Knockin' on heaven's door: Molecular mechanisms of neuronal tau uptake. Journal of Neurochemistry. PMID 32770783 DOI: 10.1111/jnc.15144   
2020 Zou K, Abdullah M, Michikawa M. Current Biomarkers for Alzheimer's Disease: From CSF to Blood. Journal of Personalized Medicine. 10. PMID 32806668 DOI: 10.3390/jpm10030085   
2020 Khandelwal M, Manglani K, Gupta S, Tiku AB. Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity. Heliyon. 6: e04499. PMID 32775714 DOI: 10.1016/j.heliyon.2020.e04499   
2020 Houben S, de Fisenne MA, Ando K, Vanden Dries V, Poncelet L, Yilmaz Z, Mansour S, De Decker R, Brion JP, Leroy K. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. Frontiers in Molecular Neuroscience. 13: 106. PMID 32765217 DOI: 10.3389/fnmol.2020.00106   
2020 Iqbal UH, Zeng E, Pasinetti GM. The Use of Antimicrobial and Antiviral Drugs in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32664669 DOI: 10.3390/ijms21144920   
2020 Taylor X, Cisternas P, You Y, You Y, Xiang S, Marambio Y, Zhang J, Vidal R, Lasagna-Reeves CA. A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy. Journal of Neuroinflammation. 17: 223. PMID 32711525 DOI: 10.1186/s12974-020-01900-7   
2020 Stage EC, Svaldi D, Phillips M, Canela VH, Duran T, Goukasian N, Risacher SL, Saykin AJ, Apostolova LG, . Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis. Alzheimer's Research & Therapy. 12: 93. PMID 32758274 DOI: 10.1186/s13195-020-00647-w   
2020 Triana-Baltzer G, Van Kolen K, Theunis C, Moughadam S, Slemmon R, Mercken M, Galpern W, Sun H, Kolb H. Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid. Journal of Alzheimer's Disease : Jad. PMID 32831201 DOI: 10.3233/JAD-200463   
2020 Khoury R, Grossberg GT. Deciphering Alzheimer's disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis. Expert Opinion On Therapeutic Targets. 1-10. PMID 32603232 DOI: 10.1080/14728222.2020.1790530   
2020 Zhang W, Bai S, Yang J, Zhang Y, Liu Y, Nie J, Meng D, Shi R, Yao Z, Wang M, Wang H, Li C. FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. Neuroscience Letters. 135322. PMID 32860886 DOI: 10.1016/j.neulet.2020.135322   
2020 Pérez-González R, Kim Y, Miller C, Pacheco-Quinto J, Eckman EA, Levy E. Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32772431 DOI: 10.1096/fj.202000823R   
2020 Ghirelli A, Tosakulwong N, Weigand SD, Clark HM, Ali F, Botha H, Duffy JR, Utianski RL, Buciuc M, Murray ME, Labuzan SA, Spychalla AJ, Pham NTT, Schwarz CG, Senjem ML, et al. Sensitivity-specificity of tau and Aβ PET in frontotemporal lobar degeneration. Annals of Neurology. PMID 32869362 DOI: 10.1002/ana.25893   
2020 Mold MJ, O'Farrell A, Morris B, Exley C. Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders. Journal of Alzheimer's Disease : Jad. PMID 32925074 DOI: 10.3233/JAD-200838   
2020 Yao Y, Nzou G, Alle T, Tsering W, Maimaiti S, Trojanowski JQ, Lee VM, Ballatore C, Brunden KR. Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32918367 DOI: 10.1002/alz.12144   
2020 Li C, Wang J, Liu L. Alzheimer's Therapeutic Strategy: Photoactive Platforms for Suppressing the Aggregation of Amyloid β Protein. Frontiers in Chemistry. 8: 509. PMID 32793545 DOI: 10.3389/fchem.2020.00509   
2020 Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG. Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. Bmc Molecular and Cell Biology. 21: 58. PMID 32731849 DOI: 10.1186/s12860-020-00302-0   
2020 Sharma M, Tiwari V, Shukla S, Panda JJ. Fluorescent Dopamine-tryptophan nanocomposites as dual imaging and anti-aggregation agents: New generation of amyloid theranostics with trimeric effects. Acs Applied Materials & Interfaces. PMID 32870652 DOI: 10.1021/acsami.0c13223   
2020 Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, , et al. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. Embo Molecular Medicine. e12308. PMID 32790063 DOI: 10.15252/emmm.202012308   
2020 Henríquez G, Gomez A, Guerrero ED, Narayan M. The Potential Role of Natural Polyphenols Against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical studies. Acs Chemical Neuroscience. PMID 32822152 DOI: 10.1021/acschemneuro.0c00381   
2020 Shi WY, Wang ZT, Sun FR, Ma YH, Xu W, Shen XN, Dong Q, Tan L, Yu JT, Yu Y, . High pulse pressure is a risk factor for prodromal Alzheimer's disease: a longitudinal study. Aging. 12. PMID 32960784 DOI: 10.18632/aging.103678   
2020 Busche MA, Hyman BT. Synergy between amyloid-β and tau in Alzheimer's disease. Nature Neuroscience. PMID 32778792 DOI: 10.1038/s41593-020-0687-6   
2020 Chiasseu M, Fesharaki A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology of Disease. 145: 105059. PMID 32858147 DOI: 10.1016/j.nbd.2020.105059   
2020 Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Frontiers in Neuroscience. 14: 705. PMID 32714142 DOI: 10.3389/fnins.2020.00705   
2020 Muralidar S, Ambi SV, Sekaran S, Thirumalai D, Palaniappan B. Role of tau protein in Alzheimer's disease: The prime pathological player. International Journal of Biological Macromolecules. PMID 32784025 DOI: 10.1016/j.ijbiomac.2020.07.327   
2020 Caligiore D, Silvetti M, D'Amelio M, Puglisi-Allegra S, Baldassarre G. Computational Modeling of Catecholamines Dysfunction in Alzheimer's Disease at Pre-Plaque Stage. Journal of Alzheimer's Disease : Jad. 77: 275-290. PMID 32741822 DOI: 10.3233/JAD-200276   
2020 Anu K R, Das S, Joseph A, Shenoy GG, Alex AT, Mudgal J. Neurodegenerative Pathways in Alzheimer's Disease: A Review. Current Neuropharmacology. PMID 32851951 DOI: 10.2174/1570159X18666200807130637   
2020 Lauwers E, Lalli G, Brandner S, Collinge J, Compernolle V, Duyckaerts C, Edgren G, Haïk S, Hardy J, Helmy A, Ivinson AJ, Jaunmuktane Z, Jucker M, Knight R, Lemmens R, et al. Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet. Neurology. 19: 872-878. PMID 32949547 DOI: 10.1016/S1474-4422(20)30238-6   
2020 Kwon Y, Shin J, Nam K, An JS, Yang SH, Hong SH, Bae M, Moon K, Cho Y, Woo J, Park K, Kim K, Shin J, Kim BY, Kim Y, et al. Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer's disease. Angewandte Chemie (International Ed. in English). PMID 32844539 DOI: 10.1002/anie.202009294   
2020 Plascencia-Villa G, Perry G. Status and future directions of clinical trials in Alzheimer's disease. International Review of Neurobiology. 154: 3-50. PMID 32739008 DOI: 10.1016/bs.irn.2020.03.022   
2020 Iaccarino L, La Joie R, Edwards L, Strom A, Schonhaut DR, Ossenkoppele R, Pham J, Mellinger T, Janabi M, Baker SL, Soleimani-Meigooni D, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum. Cerebral Cortex (New York, N.Y. : 1991). PMID 32808011 DOI: 10.1093/cercor/bhaa184   
2020 Race B, Williams K, Striebel JF, Chesebro B. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of Disease. 144: 105057. PMID 32829029 DOI: 10.1016/j.nbd.2020.105057   
2020 Vemula PK, Jing Y, Cicolini J, Zhang H, Mockett BG, Abraham WC, Liu P. Altered brain arginine metabolism with age in the APP/PSEN1 mouse model of Alzheimer's disease. Neurochemistry International. 104798. PMID 32711019 DOI: 10.1016/j.neuint.2020.104798   
2020 Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice. The Journal of Biological Chemistry. PMID 32913125 DOI: 10.1074/jbc.RA119.012330   
2020 Fung S, Smith CL, Prater KE, Case A, Green K, Osnis L, Winston C, Kinoshita Y, Sopher B, Morrison RS, Garden GA, Jayadev S. Early-Onset Familial Alzheimer's Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype. Journal of Alzheimer's Disease : Jad. PMID 32741831 DOI: 10.3233/JAD-200492   
2020 Dey M, Gunn-Moore FJ, Platt B, Smith TK. Brain region-specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer's disease. Lipids in Health and Disease. 19: 201. PMID 32867761 DOI: 10.1186/s12944-020-01367-8