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Robert A. Marr, Ph.D. - Publications

Affiliations: 
Neuroscience Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States 
Area:
Alzheimer's disease
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Mustaly-Kalimi S, Gallegos W, Marr RA, Gilman-Sachs A, Peterson DA, Sekler I, Stutzmann GE. Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 119: e2211999119. PMID 36442130 DOI: 10.1073/pnas.2211999119  0.357
2020 Maigler K, Buhr T, Park C, Miller S, Kozlowski DA, Marr R. Assessment of the effects of altered amyloid-beta clearance on behavior following repeat closed-head brain injury in APP humanized mice. Journal of Neurotrauma. PMID 33176547 DOI: 10.1089/neu.2020.6989  0.743
2020 Schrank S, McDaid J, Briggs CA, Mustaly-Kalimi S, Brinks D, Houcek A, Singer O, Bottero V, Marr RA, Stutzmann GE. Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology. International Journal of Molecular Sciences. 21. PMID 32033164 DOI: 10.3390/Ijms21031030  0.462
2018 Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML. Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29628304 DOI: 10.1016/J.Ymthe.2018.02.029  0.523
2018 Lim PH, Wert SL, Tunc-Ozcan E, Marr R, Ferreira A, Redei EE. Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression. Behavioural Brain Research. PMID 29490235 DOI: 10.1016/J.Bbr.2018.02.030  0.354
2018 Schrank S, Briggs C, McDaid J, Maigler K, Marr R, Stutzmann GE. P3-074: Human Induced Neurons Model Hallmarks Of Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1430  0.349
2016 Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML. Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides. Embo Molecular Medicine. PMID 26902204 DOI: 10.15252/Emmm.201505846  0.514
2015 Bonds JA, Kuttner-Hirshler Y, Bartolotti N, Tobin MK, Pizzi M, Marr R, Lazarov O. Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. Plos One. 10: e0131266. PMID 26098332 DOI: 10.1371/Journal.Pone.0131266  0.309
2014 Marr RA. Editorial on, "Amyloid-beta clearance in Alzheimer's disease". Frontiers in Aging Neuroscience. 6: 310. PMID 25477816 DOI: 10.3389/Fnagi.2014.00310  0.415
2014 Philibert KD, Marr RA, Norstrom EM, Glucksman MJ. Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches. Frontiers in Aging Neuroscience. 6: 265. PMID 25346686 DOI: 10.3389/Fnagi.2014.00265  0.517
2014 Marr RA, Hafez DM. Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Frontiers in Aging Neuroscience. 6: 187. PMID 25165447 DOI: 10.3389/Fnagi.2014.00187  0.781
2013 Lazarov O, Marr RA. Of mice and men: neurogenesis, cognition and Alzheimer's disease. Frontiers in Aging Neuroscience. 5: 43. PMID 23986699 DOI: 10.3389/Fnagi.2013.00043  0.38
2012 Hafez DM, Huang JY, Richardson JC, Masliah E, Peterson DA, Marr RA. F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice. Neuroscience. 223: 465-72. PMID 22863679 DOI: 10.1016/J.Neuroscience.2012.07.038  0.778
2012 Huang JY, Hafez DM, James BD, Bennett DA, Marr RA. Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 433-41. PMID 22008264 DOI: 10.3233/Jad-2011-111307  0.759
2012 Bruno AM, Huang JY, Bennett DA, Marr RA, Hastings ML, Stutzmann GE. Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 33: 1001.e1-6. PMID 21531043 DOI: 10.1016/J.Neurobiolaging.2011.03.011  0.582
2011 Spencer B, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E. Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease. Plos One. 6: e16575. PMID 21304989 DOI: 10.1371/Journal.Pone.0016575  0.652
2011 Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E, Marr RA. Neprilysin-2 is an important β-amyloid degrading enzyme. The American Journal of Pathology. 178: 306-12. PMID 21224067 DOI: 10.1016/J.Ajpath.2010.11.012  0.783
2011 Hanson LR, Hafez D, Svitak AL, Burns RB, Li X, Frey WH, Marr RA. Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice. Journal of Molecular Neuroscience : Mn. 43: 424-7. PMID 20941644 DOI: 10.1007/S12031-010-9460-8  0.793
2011 Lazarov O, Gadadhar A, Marr R. P3-191: Alzheimer's disease and neurogenesis: Familial(r) signaling, new roles Alzheimer's & Dementia. 7: S577-S578. DOI: 10.1016/J.Jalz.2011.05.1632  0.311
2010 Marr RA, Spencer BJ. NEP-like endopeptidases and Alzheimer's disease [corrected]. Current Alzheimer Research. 7: 223-9. PMID 20088804 DOI: 10.2174/156720510791050849  0.462
2010 Lazarov O, Marr RA. Neurogenesis and Alzheimer's disease: at the crossroads. Experimental Neurology. 223: 267-81. PMID 19699201 DOI: 10.1016/J.Expneurol.2009.08.009  0.426
2010 Marr RA, Hafez D, Huang J, Huynh A, Bruno A, Valtierra S, Rockenstein E, DesGroseillers L, Lu B, Frey W, Hanson L, Bennett D, Masliah E. O2-03-06: Nep-like proteases are important Aß degrading enzymes Alzheimer's & Dementia. 6: S101-S102. DOI: 10.1016/J.Jalz.2010.05.319  0.707
2009 Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1115-25. PMID 19176820 DOI: 10.1523/Jneurosci.4220-08.2009  0.556
2008 Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. Bmc Neuroscience. 9: 109. PMID 19014502 DOI: 10.1186/1471-2202-9-109  0.656
2008 Huang JY, Bruno AM, Patel CA, Huynh AM, Philibert KD, Glucksman MJ, Marr RA. Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40. Neuroscience. 155: 258-62. PMID 18571334 DOI: 10.1016/J.Neuroscience.2008.05.006  0.604
2008 El-Amouri SS, Zhu H, Yu J, Marr R, Verma IM, Kindy MS. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. The American Journal of Pathology. 172: 1342-54. PMID 18403590 DOI: 10.2353/Ajpath.2008.070620  0.658
2008 Marr RA, Huang J, Huynh A, Bruno A, Patel C, Lu B, DesGroseillers L, Bennett D, Masliah E. O2-03-02: NEP2 is an important beta-amyloid degrading enzyme Alzheimer's & Dementia. 4: T135-T136. DOI: 10.1016/J.Jalz.2008.05.323  0.567
2008 Gadadhar A, Marr R, Lazarov O. P3-382: The role Of presenilin-1 in adult neurogenesis: Implications for Alzheimer's disease Alzheimer's & Dementia. 4: T633-T633. DOI: 10.1016/J.Jalz.2008.05.1952  0.355
2007 Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opinion On Biological Therapy. 7: 1853-67. PMID 18034651 DOI: 10.1517/14712598.7.12.1853  0.509
2006 Singer O, Marr RA, Rockenstein E, Crow L, Gage FH, Verma IM, Masliah E. 81. Hippocampal Gene Knockdown of BACE1 by Lentiviral Gene Transfer of siRNA Reduces Amyloid Pathology and Improves Memory Performance in APP Transgenic Mice Molecular Therapy. 13: S34. DOI: 10.1016/J.Ymthe.2006.08.099  0.689
2006 Mustaly SH, Garstka M, Kapecki N, Beaman KD, Gilman-Sachs A, McDaid J, Schrank S, Marr R, Stutzmann GE. P1-216: LYSOSOME-AUTOPHAGOSOME DEFECTS MEDIATE PROTEINOPATHY AND SYNAPTIC PATHOPHYSIOLOGY IN EARLY STAGES OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P361-P361. DOI: 10.1016/J.Jalz.2018.06.221  0.329
2005 Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, Ellison JA, Schadt EE, Verma IM, Lockhart DJ, Barlow C. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 438: 662-6. PMID 16244648 DOI: 10.1038/Nature04250  0.47
2005 Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience. 8: 1343-9. PMID 16136043 DOI: 10.1038/Nn1531  0.661
2005 Dodart JC, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 1211-6. PMID 15657137 DOI: 10.1073/Pnas.0409072102  0.67
2005 Singer O, Marr RA, Rockenstein E, Crews L, Gage FH, Verma IM, Masliah E. 56. Amelioration of Neurodegenerative and Neuropathological Alterations in a Transgenic Model of Alzheimer's Disease: Targeting BACE1 with Small Interfering RNAs Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.084  0.689
2004 Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Therapy. 11: 1713-23. PMID 15483670 DOI: 10.1038/Sj.Gt.3302349  0.408
2004 Kankkonen HM, Vähäkangas E, Marr RA, Pakkanen T, Laurema A, Leppänen P, Jalkanen J, Verma IM, Ylä-Herttuala S. Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 548-56. PMID 15093185 DOI: 10.1016/J.Ymthe.2004.01.015  0.452
2004 Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. Journal of Molecular Neuroscience : Mn. 22: 5-11. PMID 14742905 DOI: 10.1385/Jmn:22:1-2:5  0.631
2004 Marr RA, Rockenstien E, Kindy MS, Hersh LB, Gage FH, Masliah E, Verma IM. 525. Therapy for Alzheimer's disease by neprilysin gene transfer Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.470  0.672
2003 Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1992-6. PMID 12657655 DOI: 10.1523/Jneurosci.23-06-01992.2003  0.684
1999 Marr RA, Hitt M, Gauldie J, Muller WJ, Graham FL. A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity. Cancer Gene Therapy. 6: 465-74. PMID 10505857 DOI: 10.1038/Sj.Cgt.7700068  0.351
1998 Lei XF, Ohkawara Y, Stämpfli MR, Mastruzzo C, Marr RA, Snider D, Xing Z, Jordana M. Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice. The Journal of Clinical Investigation. 101: 1342-53. PMID 9502776 DOI: 10.1172/Jci1662  0.383
1998 Marr RA, Hitt M, Muller WJ, Gauldie J, Graham FL. Tumour therapy in mice using adenovirus vectors expressing human TNFa. International Journal of Oncology. 12: 509-15. PMID 9472086 DOI: 10.3892/Ijo.12.3.509  0.416
1997 Marr RA, Addison CL, Snider D, Muller WJ, Gauldie J, Graham FL. Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNF alpha. Gene Therapy. 4: 1181-8. PMID 9425441 DOI: 10.1038/Sj.Gt.3300528  0.378
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