| Year |
Citation |
Score |
| 2023 |
Romero CA, Lim J, Wang H, Wynne BM, Ma P, Jing Y, Liotta DC, D'Erasmo M, Traynelis SF, Eaton DC, Wall SM. Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation. Biorxiv : the Preprint Server For Biology. PMID 38106229 DOI: 10.1101/2023.12.04.569973 |
0.402 |
|
| 2023 |
Allen JP, Garber KB, Perszyk R, Khayat CT, Kell SA, Kaneko M, Quindipan C, Saitta S, Ladda RL, Hewson S, Inbar-Feigenberg M, Prasad C, Prasad AN, Olewiler L, Mu W, ... ... Traynelis SF, et al. Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. Human Molecular Genetics. PMID 37944084 DOI: 10.1093/hmg/ddad188 |
0.815 |
|
| 2023 |
XiangWei W, Perszyk RE, Liu N, Xu Y, Bhattacharya S, Shaulsky GH, Smith-Hicks C, Fatemi A, Fry AE, Chandler K, Wang T, Vogt J, Cohen JS, Paciorkowski AR, Poduri A, ... ... Traynelis SF, et al. Clinical and functional consequences of GRIA variants in patients with neurological diseases. Cellular and Molecular Life Sciences : Cmls. 80: 345. PMID 37921875 DOI: 10.1007/s00018-023-04991-6 |
0.851 |
|
| 2023 |
Camp CR, Vlachos A, Klöckner C, Krey I, Banke TG, Shariatzadeh N, Ruggiero SM, Galer P, Park KL, Caccavano A, Kimmel S, Yuan X, Yuan H, Helbig I, Benke TA, ... ... Traynelis SF, et al. Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons. Communications Biology. 6: 952. PMID 37723282 DOI: 10.1038/s42003-023-05298-9 |
0.824 |
|
| 2023 |
Song R, Zhang J, Perszyk RE, Camp CR, Tang W, Kannan V, Li J, Xu Y, Chen J, Li Y, Liang SH, Traynelis SF, Yuan H. Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors. Journal of Neurochemistry. PMID 37649269 DOI: 10.1111/jnc.15942 |
0.858 |
|
| 2023 |
Liu N, Li J, Gao K, Perszyk RE, Zhang J, Wang J, Wu Y, Jenkins A, Yuan H, Traynelis SF, Jiang Y. De novo CLPTM1 variants with reduced GABA R current response in patients with epilepsy. Epilepsia. PMID 37577761 DOI: 10.1111/epi.17746 |
0.774 |
|
| 2023 |
D'Erasmo MP, Akins NS, Ma P, Jing Y, Swanger SA, Sharma SK, Bartsch PW, Menaldino DS, Arcoria PJ, Bui TT, Pons-Bennaceur A, Le P, Allen JP, Ullman EZ, Nocilla KA, ... ... Traynelis SF, et al. Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the -Methyl-d-aspartate Receptor. Acs Chemical Neuroscience. PMID 37566734 DOI: 10.1021/acschemneuro.3c00181 |
0.853 |
|
| 2023 |
Camp CR, Traynelis SF. Additional Depth to the NMDA Receptor Hypofunction and Parvalbumin Cell Dysfunction Hypotheses of Schizophrenia. Biological Psychiatry. 94: 283-284. PMID 37495331 DOI: 10.1016/j.biopsych.2023.06.007 |
0.835 |
|
| 2023 |
Hanson JE, Yuan H, Perszyk RE, Banke TG, Xing H, Tsai MC, Menniti FS, Traynelis SF. Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 37369776 DOI: 10.1038/s41386-023-01614-3 |
0.872 |
|
| 2023 |
Myers SJ, Yuan H, Perszyk RE, Zhang J, Kim S, Nocilla KA, Allen JP, Bain JM, Lemke JR, Lal D, Benke TA, Traynelis SF. Classification of missense variants in the N-methyl-D-aspartate receptor GRIN gene family as gain- or loss-of-function. Human Molecular Genetics. PMID 37369021 DOI: 10.1093/hmg/ddad104 |
0.832 |
|
| 2023 |
Nguyen TT, Camp CR, Doan JK, Traynelis SF, Sloan SA, Hall RA. GPR37L1 controls maturation and organization of cortical astrocytes during development. Glia. PMID 37029775 DOI: 10.1002/glia.24375 |
0.791 |
|
| 2023 |
Xie L, McDaniel MJ, Perszyk RE, Kim S, Cappuccio G, Shapiro KA, Muñoz-Cabello B, Sanchez-Lara PA, Grand K, Zhang J, Nocilla KA, Sheikh R, Armengol L, Romano R, Pierson TM, ... ... Traynelis SF, et al. Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening. Cellular and Molecular Life Sciences : Cmls. 80: 110. PMID 37000222 DOI: 10.1007/s00018-023-04705-y |
0.829 |
|
| 2023 |
Harris LD, Regan MC, Myers SJ, Nocilla KA, Akins NS, Tahirovic YA, Wilson LJ, Dingledine R, Furukawa H, Traynelis SF, Liotta DC. Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. Acs Chemical Neuroscience. PMID 36779874 DOI: 10.1021/acschemneuro.2c00779 |
0.74 |
|
| 2023 |
Tang W, Beckley JT, Zhang J, Song R, Xu Y, Kim S, Quirk MC, Robichaud AJ, Diaz ES, Myers SJ, Doherty JJ, Ackley MA, Traynelis SF, Yuan H. Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions. Cellular and Molecular Life Sciences : Cmls. 80: 42. PMID 36645496 DOI: 10.1007/s00018-022-04667-7 |
0.77 |
|
| 2023 |
Zaczek R, Traynelis SF, Dingledine R, Koszalka GW, Laskowitz DT. Phase 1 Clinical Results for NP10679, a pH-sensitive GluN2B-selective N-methyl-d-aspartate Receptor Inhibitor. Clinical Pharmacology in Drug Development. PMID 36642931 DOI: 10.1002/cpdd.1217 |
0.584 |
|
| 2022 |
Montanez-Miranda C, Perszyk RE, Harbin NH, Okalova J, Ramineni S, Traynelis SF, Hepler JR. . Molecular Pharmacology. PMID 36384958 DOI: 10.1124/molpharm.122.000614 |
0.711 |
|
| 2022 |
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H. Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Molecular Cell. PMID 36309015 DOI: 10.1016/j.molcel.2022.10.008 |
0.752 |
|
| 2022 |
Han W, Yuan H, Allen JP, Kim S, Shaulsky GH, Perszyk RE, Traynelis SF, Myers SJ. . The Journal of Pharmacology and Experimental Therapeutics. PMID 35110392 DOI: 10.1124/jpet.121.001000 |
0.865 |
|
| 2021 |
Hansen KB, Wollmuth LP, Bowie D, Furukawa H, Menniti FS, Sobolevsky AI, Swanson GT, Swanger SA, Greger IH, Nakagawa T, McBain CJ, Jayaraman V, Low CM, Dell'Acqua ML, Diamond JS, ... ... Traynelis SF, et al. Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews. 73: 298-487. PMID 34753794 DOI: 10.1124/pharmrev.120.000131 |
0.858 |
|
| 2021 |
Benke TA, Park K, Krey I, Camp CR, Song R, Ramsey AJ, Yuan H, Traynelis SF, Lemke J. Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs. Neuropharmacology. 108805. PMID 34560056 DOI: 10.1016/j.neuropharm.2021.108805 |
0.795 |
|
| 2021 |
Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34493631 DOI: 10.1124/jpet.120.000370 |
0.304 |
|
| 2021 |
Zhang J, Tang W, Bhatia NK, Xu Y, Paudyal N, Liu D, Kim S, Song R, XiangWei W, Shaulsky G, Myers SJ, Dobyns W, Jayaraman V, Traynelis SF, Yuan H, et al. A Variant Associated With Myoclonus and Developmental Delay: From Molecular Mechanism to Rescue Pharmacology. Frontiers in Genetics. 12: 694312. PMID 34413877 DOI: 10.3389/fgene.2021.694312 |
0.686 |
|
| 2021 |
Perszyk RE, Kristensen AS, Lyuboslavsky P, Traynelis SF. Three-dimensional missense tolerance ratio analysis. Genome Research. PMID 34301626 DOI: 10.1101/gr.275528.121 |
0.799 |
|
| 2021 |
Xu Y, Song R, Chen W, Strong K, Shrey D, Gedela S, Traynelis SF, Zhang G, Yuan H. Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy. Annals of Clinical and Translational Neurology. PMID 34227748 DOI: 10.1002/acn3.51406 |
0.819 |
|
| 2021 |
Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, et al. Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain. 14: 103. PMID 34187529 DOI: 10.1186/s13041-021-00811-9 |
0.853 |
|
| 2021 |
Perszyk RE, Yip MC, McConnell OL, Wang ET, Jenkins A, Traynelis SF, Forest CR. Automated intracellular pharmacological electrophysiology for ligand-gated ionotropic receptor and pharmacology screening. Molecular Pharmacology. PMID 33958481 DOI: 10.1124/molpharm.120.000195 |
0.81 |
|
| 2021 |
Perszyk RE, Zheng Z, Banke TG, Zhang J, Xie L, McDaniel MJ, Katzman BM, Pelly SC, Yuan H, Liotta DC, Traynelis SF. . Molecular Pharmacology. PMID 33688039 DOI: 10.1124/molpharm.120.000218 |
0.875 |
|
| 2020 |
Strong KL, Epplin MP, Ogden KK, Burger PB, Kaiser TM, Wilding TJ, Kusumoto H, Camp CR, Shaulsky G, Bhattacharya S, Perszyk RE, Menaldino DS, McDaniel MJ, Zhang J, Le P, ... ... Traynelis SF, et al. Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of -Methyl-d-aspartate Receptors. Acs Chemical Neuroscience. PMID 33326224 DOI: 10.1021/acschemneuro.0c00561 |
0.857 |
|
| 2020 |
Tang W, Liu D, Traynelis SF, Yuan H. Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders. Neuropharmacology. 108247. PMID 32712275 DOI: 10.1016/J.Neuropharm.2020.108247 |
0.738 |
|
| 2020 |
Amador A, Bostick CD, Olson H, Peters J, Camp CR, Krizay D, Chen W, Han W, Tang W, Kanber A, Kim S, Teoh J, Sah M, Petri S, Paek H, ... ... Traynelis SF, et al. Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice. Brain : a Journal of Neurology. PMID 32577763 DOI: 10.1093/Brain/Awaa147 |
0.844 |
|
| 2020 |
Epplin M, Mohan A, Harris L, Zhu Z, Strong KL, Bacsa J, Le P, Menaldino DS, Traynelis SF, Liotta DC. The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor. Journal of Medicinal Chemistry. PMID 32538088 DOI: 10.1021/Acs.Jmedchem.9B01733 |
0.867 |
|
| 2020 |
Perszyk RE, Myers SJ, Yuan H, Gibb AJ, Furukawa H, Sobolevsky AI, Traynelis SF. Hodgkin-huxley-katz prize lecture: genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif. The Journal of Physiology. PMID 32468591 DOI: 10.1113/Jp278086 |
0.866 |
|
| 2020 |
Zhu Z, Yi F, Epplin MP, Liu D, Summer SL, Mizu R, Shaulsky G, XiangWei W, Tang W, Burger PB, Menaldino DS, Myers SJ, Liotta DC, Hansen KB, Yuan H, ... Traynelis SF, et al. Negative allosteric modulation of GluN1/GluN3 NMDA receptors. Neuropharmacology. 108117. PMID 32389749 DOI: 10.1016/J.Neuropharm.2020.108117 |
0.881 |
|
| 2020 |
Piard J, Béreau M, XiangWei W, Wirth T, Amsallem D, Buisson L, Richard P, Liu N, Xu Y, Myers SJ, Traynelis SF, Chelly J, Anheim M, Raynaud M, Maldergem LV, et al. The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32369665 DOI: 10.1002/Mds.28058 |
0.628 |
|
| 2020 |
McDaniel MJ, Ogden KK, Kell SA, Burger PB, Liotta DC, Traynelis SF. NMDA receptor channel gating control by the pre-M1 helix. The Journal of General Physiology. 152. PMID 32221541 DOI: 10.1085/Jgp.201912362 |
0.84 |
|
| 2020 |
Perszyk RE, Swanger SA, Shelley C, Khatri A, Fernandez-Cuervo G, Epplin MP, Zhang J, Le P, Bülow P, Garnier-Amblard E, Gangireddy PKR, Bassell GJ, Yuan H, Menaldino DS, Liotta DC, ... ... Traynelis SF, et al. Biased modulators of NMDA receptors control channel opening and ion selectivity. Nature Chemical Biology. PMID 31959964 DOI: 10.1038/S41589-019-0449-5 |
0.838 |
|
| 2019 |
Myers SJ, Yuan H, Kang JQ, Tan FCK, Traynelis SF, Low CM. Distinct roles of and variants in neurological conditions. F1000research. 8. PMID 31807283 DOI: 10.12688/F1000Research.18949.1 |
0.649 |
|
| 2019 |
Yi F, Bhattacharya S, Thompson CM, Traynelis SF, Hansen KB. Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors. The Journal of Physiology. PMID 31541561 DOI: 10.1113/Jp278168 |
0.855 |
|
| 2019 |
XiangWei W, Kannan V, Xu Y, Kosobucki GJ, Schulien AJ, Kusumoto H, Moufawad El Achkar C, Bhattacharya S, Lesca G, Nguyen S, Helbig KL, Cuisset JM, Fenger CD, Marjanovic D, Schuler E, ... ... Traynelis SF, et al. Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy. Brain : a Journal of Neurology. PMID 31504254 DOI: 10.1093/Brain/Awz232 |
0.862 |
|
| 2019 |
Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Perozo E, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, ... ... Traynelis SF, et al. De Novo GRIN Variants in NMDA Receptor M2 Channel Pore-Forming Loop Are Associated with Neurological Diseases. Human Mutation. PMID 31429998 DOI: 10.1002/Humu.23895 |
0.856 |
|
| 2019 |
Summer SL, Kell SA, Zhu Z, Moore R, Liotta DC, Myers SJ, Koszalka GW, Traynelis SF, Menaldino DS. Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor. Acs Medicinal Chemistry Letters. 10: 248-254. PMID 30891121 DOI: 10.1021/Acsmedchemlett.8B00395 |
0.67 |
|
| 2019 |
Carruthers NI, Lovenberg TW, Traynelis SF. Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue. Acs Medicinal Chemistry Letters. 10: 226. PMID 30891117 DOI: 10.1021/acsmedchemlett.9b00047 |
0.476 |
|
| 2019 |
Hanson E, Armbruster M, Lau LA, Sommer ME, Klaft ZJ, Swanger SA, Traynelis SF, Moss SJ, Noubary F, Chadchankar J, Dulla CG. Tonic activation of GluN2C/GluN2D-containing NMDA receptors by ambient glutamate facilitates cortical interneuron maturation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30846615 DOI: 10.1523/Jneurosci.1392-18.2019 |
0.78 |
|
| 2019 |
Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA, ... ... Traynelis SF, et al. Antidepressant-relevant concentrations of the ketamine metabolite (2,6)-hydroxynorketamine do not block NMDA receptor function. Proceedings of the National Academy of Sciences of the United States of America. PMID 30796190 DOI: 10.1073/Pnas.1816071116 |
0.502 |
|
| 2019 |
Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers S, Giffenig P, Wang L, Josephson L, ... ... Traynelis SF, et al. Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([18F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain. Acs Chemical Neuroscience. PMID 30698943 DOI: 10.1021/Acschemneuro.8B00591 |
0.614 |
|
| 2019 |
Regan MC, Zhu Z, Yuan H, Myers SJ, Menaldino DS, Tahirovic YA, Liotta DC, Traynelis SF, Furukawa H. Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nature Communications. 10: 321. PMID 30659174 DOI: 10.2210/Pdb6E7S/Pdb |
0.843 |
|
| 2019 |
Bhattacharya S, Camp CR, Traynelis SF. Assembly and cell surface presentation of NMDA receptors Reactome - a Curated Knowledgebase of Biological Pathways. 68. DOI: 10.3180/R-Hsa-9609736.1 |
0.848 |
|
| 2018 |
Bhattacharya S, Traynelis SF. Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors. Journal of Experimental Neuroscience. 12: 1179069518810423. PMID 30479490 DOI: 10.1177/1179069518810423 |
0.863 |
|
| 2018 |
Wells G, Yuan H, McDaniel MJ, Kusumoto H, Snyder JP, Liotta DC, Traynelis SF. The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening. Proteins. PMID 30168177 DOI: 10.1002/Prot.25595 |
0.846 |
|
| 2018 |
Bhattacharya S, Khatri A, Swanger SA, DiRaddo JO, Yi F, Hansen KB, Yuan H, Traynelis SF. Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells. Neuron. 99: 315-328.e5. PMID 30056832 DOI: 10.1016/J.Neuron.2018.06.010 |
0.869 |
|
| 2018 |
Swanger SA, Traynelis SF. Synaptic Receptor Diversity Revealed Across Space and Time. Trends in Neurosciences. 41: 486-488. PMID 30053950 DOI: 10.1016/j.tins.2018.06.001 |
0.779 |
|
| 2018 |
Swanger SA, Traynelis SF. Synaptic Receptor Diversity Revealed Across Space and Time. Trends in Neurosciences. 41: 486-488. PMID 30053950 DOI: 10.1016/j.tins.2018.06.001 |
0.392 |
|
| 2018 |
Hansen KB, Yi F, Perszyk RE, Furukawa H, Wollmuth LP, Gibb AJ, Traynelis SF. Structure, function, and allosteric modulation of NMDA receptors. The Journal of General Physiology. PMID 30037851 DOI: 10.1085/Jgp.201812032 |
0.882 |
|
| 2018 |
Gibb A, Ogden KK, McDaniel MJ, Vance KM, Kell SA, Butch C, Burger P, Liotta DC, Traynelis SF. A structurally-derived model of subunit-dependent NMDA receptor function. The Journal of Physiology. PMID 29917241 DOI: 10.1113/Jp276093 |
0.873 |
|
| 2018 |
Carruthers NI, Lovenberg TW, Traynelis SF. Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue. Acs Medicinal Chemistry Letters. 9: 398-399. PMID 29795747 DOI: 10.1021/acsmedchemlett.8b00174 |
0.385 |
|
| 2018 |
Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF. An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups. Elife. 7. PMID 29792594 DOI: 10.7554/Elife.34711 |
0.844 |
|
| 2018 |
Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H. Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron. PMID 29656875 DOI: 10.1016/J.Neuron.2018.03.034 |
0.875 |
|
| 2018 |
Fernández-Marmiesse A, Kusumoto H, Rekarte S, Roca I, Zhang J, Myers SJ, Traynelis SF, Couce ML, Gutierrez-Solana L, Yuan H. A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29644724 DOI: 10.1002/Mds.27315 |
0.834 |
|
| 2018 |
Bhattacharya S, Ma Y, Dunn AR, Bradner JM, Scimemi A, Miller GW, Traynelis SF, Wichmann T. NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate. Journal of Neuroscience Research. PMID 29577359 DOI: 10.1002/Jnr.24230 |
0.853 |
|
| 2018 |
Benke T, Traynelis SF. AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise. Neurochemical Research. PMID 29476449 DOI: 10.1007/S11064-018-2491-1 |
0.475 |
|
| 2018 |
Singh A, Jenkins MA, Burke KJ, Beck G, Jenkins A, Scimemi A, Traynelis SF, Papa SM. Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Reports. 22: 941-952. PMID 29386136 DOI: 10.1016/J.Celrep.2017.12.095 |
0.703 |
|
| 2018 |
Fry AE, Fawcett KA, Zelnik N, Yuan H, Thompson BAN, Shemer-Meiri L, Cushion TD, Mugalaasi H, Sims D, Stoodley N, Chung SK, Rees MI, Patel CV, Brueton LA, Layet V, ... ... Traynelis SF, et al. De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain : a Journal of Neurology. PMID 29365063 DOI: 10.1093/Brain/Awx358 |
0.826 |
|
| 2018 |
Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF. Author response: An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups Elife. DOI: 10.7554/Elife.34711.058 |
0.789 |
|
| 2017 |
Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor. Molecular Pharmacology. PMID 29242355 DOI: 10.1124/Mol.117.110940 |
0.874 |
|
| 2017 |
Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. A novel negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors inhibits synaptic transmission in hippocampal interneurons. Acs Chemical Neuroscience. PMID 29043770 DOI: 10.1021/Acschemneuro.7B00329 |
0.863 |
|
| 2017 |
Yi F, Traynelis SF, Hansen KB. Selective Cell-Surface Expression of Triheteromeric NMDA Receptors. Methods in Molecular Biology (Clifton, N.J.). 1677: 145-162. PMID 28986871 DOI: 10.1007/978-1-4939-7321-7_7 |
0.824 |
|
| 2017 |
Hansen KB, Yi F, Perszyk RE, Menniti FS, Traynelis SF. NMDA Receptors in the Central Nervous System. Methods in Molecular Biology (Clifton, N.J.). 1677: 1-80. PMID 28986865 DOI: 10.1007/978-1-4939-7321-7_1 |
0.883 |
|
| 2017 |
Galtieri DJ, Estep CM, Wokosin DL, Traynelis S, Surmeier DJ. Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons. Elife. 6. PMID 28980939 DOI: 10.7554/Elife.30352 |
0.328 |
|
| 2017 |
Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC. The Structure Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-ᴅ-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-ᴅ-Aspartate Receptors. Journal of Medicinal Chemistry. PMID 28586221 DOI: 10.1021/Acs.Jmedchem.7B00239 |
0.863 |
|
| 2017 |
Hu C, Chen W, Myers SJ, Yuan H, Traynelis SF. Corrigendum to "Human GRIN2B variants in neurodevelopmental disorders" [J Pharmacol Sci 132 (2) 115-121]. Journal of Pharmacological Sciences. PMID 28434657 DOI: 10.1016/J.Jphs.2017.04.001 |
0.633 |
|
| 2017 |
Platzer K, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, ... ... Traynelis SF, et al. GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects. Journal of Medical Genetics. PMID 28377535 DOI: 10.1136/Jmedgenet-2016-104509 |
0.771 |
|
| 2017 |
Liu S, Zhou L, Yuan H, Vieira M, Sanz-Clemente A, Badger JD, Lu W, Traynelis SF, Roche KW. A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28283559 DOI: 10.1523/Jneurosci.0827-16.2017 |
0.722 |
|
| 2017 |
Chen W, Shieh C, Swanger SA, Tankovic A, Au M, McGuire M, Tagliati M, Graham JM, Madan-Khetarpal S, Traynelis SF, Yuan H, Pierson TM. GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function. Journal of Human Genetics. PMID 28228639 DOI: 10.1038/Jhg.2017.19 |
0.826 |
|
| 2017 |
Gao K, Tankovic A, Zhang Y, Kusumoto H, Zhang J, Chen W, XiangWei W, Shaulsky GH, Hu C, Traynelis SF, Yuan H, Jiang Y. A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia. Plos One. 12: e0170818. PMID 28182669 DOI: 10.1371/Journal.Pone.0170818 |
0.809 |
|
| 2017 |
Chen W, Tankovic A, Burger PB, Kusumoto H, Traynelis SF, Yuan H. Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy. Molecular Pharmacology. PMID 28126851 DOI: 10.1124/Mol.116.106781 |
0.858 |
|
| 2017 |
Ogden KK, Chen W, Swanger SA, McDaniel MJ, Fan LZ, Hu C, Tankovic A, Kusumoto H, Kosobucki GJ, Schulien AJ, Su Z, Pecha J, Bhattacharya S, Petrovski S, Cohen AE, ... ... Traynelis SF, et al. Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology. Plos Genetics. 13: e1006536. PMID 28095420 DOI: 10.1371/Journal.Pgen.1006536 |
0.852 |
|
| 2017 |
Perszyk RE, Ogden KK, Strong KL, Liotta DC, Traynelis SF. Channel Open Probability Controls Allosteric Modulation of Potency and Efficacy Biophysical Journal. 112: 420a-421a. DOI: 10.1016/J.Bpj.2016.11.2249 |
0.791 |
|
| 2016 |
Tamborini L, Chen Y, Foss CA, Pinto A, Horti AG, Traynelis SF, De Micheli C, Mease RC, Hansen KB, Conti P, Pomper MG. Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain. Journal of Medicinal Chemistry. 59: 11110-11119. PMID 28002957 DOI: 10.1021/Acs.Jmedchem.6B01344 |
0.619 |
|
| 2016 |
Keen JR, Swanger SA, Traynelis SF, Olson JJ. The role of glutamate transport and SLC7A11 expression in tumor-associate seizures and survival in patients with malignant gliomas. Annals of Translational Medicine. 4: S18. PMID 27867986 DOI: 10.21037/atm.2016.10.23 |
0.678 |
|
| 2016 |
Swanger SA, Chen W, Wells G, Burger PB, Tankovic A, Bhattacharya S, Strong KL, Hu C, Kusumoto H, Zhang J, Adams DR, Millichap JJ, Petrovski S, Traynelis SF, Yuan H. Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains. American Journal of Human Genetics. PMID 27839871 DOI: 10.1016/J.Ajhg.2016.10.002 |
0.833 |
|
| 2016 |
Hu C, Chen W, Myers SJ, Yuan H, Traynelis SF. Human GRIN2B variants in neurodevelopmental disorders. Journal of Pharmacological Sciences. PMID 27818011 DOI: 10.1016/J.Jphs.2016.10.002 |
0.681 |
|
| 2016 |
Perszyk RE, DiRaddo JO, Strong KL, Low CM, Ogden KK, Khatri A, Vargish GA, Pelkey KA, Tricoire L, Liotta DC, Smith Y, McBain CJ, Traynelis SF. GluN2D-containing NMDA receptors mediate synaptic transmission in hippocampal interneurons and regulate interneuron activity. Molecular Pharmacology. PMID 27625038 DOI: 10.1124/Mol.116.105130 |
0.837 |
|
| 2016 |
Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, ... ... Traynelis SF, et al. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. American Journal of Human Genetics. PMID 27616483 DOI: 10.1016/J.Ajhg.2016.07.013 |
0.844 |
|
| 2016 |
Gyoneva S, Swanger SA, Zhang J, Weinshenker D, Traynelis SF. Altered motility of plaque-associated microglia in a model of Alzheimer's disease. Neuroscience. PMID 27288150 DOI: 10.1016/J.Neuroscience.2016.05.061 |
0.782 |
|
| 2016 |
Taylor CP, Traynelis SF, Siffert J, Pope LE, Matsumoto RR. Pharmacology of Dextromethorphan: Relevance to Dextromethorphan/Quinidine (Nuedexta®) Clinical Use. Pharmacology & Therapeutics. PMID 27139517 DOI: 10.1016/J.Pharmthera.2016.04.010 |
0.486 |
|
| 2015 |
Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pohlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF. Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Molecular Pharmacology. PMID 26661043 DOI: 10.1124/Mol.115.100909 |
0.853 |
|
| 2015 |
Swanger SA, Vance KM, Pare JF, Sotty F, Fog K, Smith Y, Traynelis SF. NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15971-83. PMID 26631477 DOI: 10.1523/Jneurosci.1702-15.2015 |
0.876 |
|
| 2015 |
Butler AJ, Kallos J, Housley SN, LaPlaca MC, Traynelis SF, Wolf SL. Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke. Rehabilitation Research and Practice. 2015: 534239. PMID 26587287 DOI: 10.1155/2015/534239 |
0.373 |
|
| 2015 |
Katzman BM, Perszyk RE, Yuan H, Tahirovic YA, Sotimehin AE, Traynelis SF, Liotta DC. A novel class of negative allosteric modulators of NMDA receptor function. Bioorganic & Medicinal Chemistry Letters. 25: 5583-8. PMID 26525866 DOI: 10.1016/J.Bmcl.2015.10.046 |
0.876 |
|
| 2015 |
Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Molecular Pharmacology. 88: 139-40. PMID 25943115 DOI: 10.1124/mol.115.099564 |
0.621 |
|
| 2015 |
Yuan H, Low CM, Moody OA, Jenkins A, Traynelis SF. Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases. Molecular Pharmacology. 88: 203-17. PMID 25904555 DOI: 10.1124/Mol.115.097998 |
0.753 |
|
| 2015 |
Heinzen EL, Neale BM, Traynelis SF, Allen AS, Goldstein DB. The Genetics of Neuropsychiatric Diseases: Looking In and Beyond the Exome. Annual Review of Neuroscience. 38: 47-68. PMID 25840007 DOI: 10.1146/annurev-neuro-071714-034136 |
0.376 |
|
| 2015 |
Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". Journal of Medicinal Chemistry. 58: 2862. PMID 25738634 DOI: 10.1021/Acs.Jmedchem.5B00199 |
0.773 |
|
| 2015 |
Yuan H, Myers SJ, Wells G, Nicholson KL, Swanger SA, Lyuboslavsky P, Tahirovic YA, Menaldino DS, Ganesh T, Wilson LJ, Liotta DC, Snyder JP, Traynelis SF. Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects. Neuron. 85: 1305-18. PMID 25728572 DOI: 10.1016/J.Neuron.2015.02.008 |
0.816 |
|
| 2015 |
Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, et al. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain. 8: 7. PMID 25645137 DOI: 10.1186/S13041-015-0097-Y |
0.843 |
|
| 2015 |
Poulsen MH, Andersen J, Christensen R, Hansen KB, Traynelis SF, Strømgaard K, Kristensen AS. Binding of ArgTX-636 in the NMDA receptor ion channel. Journal of Molecular Biology. 427: 176-89. PMID 24862283 DOI: 10.1016/J.Jmb.2014.05.017 |
0.792 |
|
| 2015 |
Berkovic SF, Scheffer IE, Petrou S, Delanty N, Dixon-Salazar TJ, Dlugos DJ, Helbig I, Frankel WN, Goldstein DB, Heinzen EL, Lowenstein DH, Mefford HC, Parent JM, Poduri A, Traynelis SF. A roadmap for precision medicine in the epilepsies The Lancet Neurology. 14: 1219-1228. DOI: 10.1016/S1474-4422(15)00199-4 |
0.336 |
|
| 2014 |
Strong KL, Jing Y, Prosser AR, Traynelis SF, Liotta DC. NMDA receptor modulators: an updated patent review (2013-2014). Expert Opinion On Therapeutic Patents. 24: 1349-66. PMID 25351527 DOI: 10.1517/13543776.2014.972938 |
0.875 |
|
| 2014 |
Hansen KB, Traynelis SF. Glutamate receptors: mechanistic twists and turns. Nature Chemical Biology. 10: 698-9. PMID 25271345 DOI: 10.1038/Nchembio.1614 |
0.721 |
|
| 2014 |
Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Molecular Pharmacology. 86: 548-60. PMID 25205677 DOI: 10.1124/Mol.114.094516 |
0.88 |
|
| 2014 |
Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC. Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors. Journal of Medicinal Chemistry. 57: 4975. PMID 24878076 DOI: 10.1021/jm500710w |
0.83 |
|
| 2014 |
Adams DR, Yuan H, Holyoak T, Arajs KH, Hakimi P, Markello TC, Wolfe LA, Vilboux T, Burton BK, Fajardo KF, Grahame G, Holloman C, Sincan M, Smith AC, Wells GA, ... Traynelis SF, et al. Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. Molecular Genetics and Metabolism. 113: 161-70. PMID 24863970 DOI: 10.1016/J.Ymgme.2014.04.001 |
0.696 |
|
| 2014 |
Pierson TM, Yuan H, Marsh ED, Fuentes-Fajardo K, Adams DR, Markello T, Golas G, Simeonov DR, Holloman C, Tankovic A, Karamchandani MM, Schreiber JM, Mullikin JC, Tifft CJ, ... Traynelis SF, et al. GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Annals of Clinical and Translational Neurology. 1: 190-198. PMID 24839611 DOI: 10.1002/Acn3.39 |
0.727 |
|
| 2014 |
Gyoneva S, Davalos D, Biswas D, Swanger SA, Garnier-Amblard E, Loth F, Akassoglou K, Traynelis SF. Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia. 62: 1345-60. PMID 24807189 DOI: 10.1002/Glia.22686 |
0.809 |
|
| 2014 |
Gyoneva S, Shapiro L, Lazo C, Garnier-Amblard E, Smith Y, Miller GW, Traynelis SF. Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease. Neurobiology of Disease. 67: 191-202. PMID 24632419 DOI: 10.1016/J.Nbd.2014.03.004 |
0.788 |
|
| 2014 |
Hansen KB, Ogden KK, Yuan H, Traynelis SF. Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors. Neuron. 81: 1084-96. PMID 24607230 DOI: 10.1016/J.Neuron.2014.01.035 |
0.882 |
|
| 2014 |
Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators. Journal of Medicinal Chemistry. 57: 2334-56. PMID 24512267 DOI: 10.1021/Jm401695D |
0.877 |
|
| 2014 |
Yuan H, Hansen KB, Zhang J, Pierson TM, Markello TC, Fajardo KV, Holloman CM, Golas G, Adams DR, Boerkoel CF, Gahl WA, Traynelis SF. Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nature Communications. 5: 3251. PMID 24504326 DOI: 10.1038/Ncomms4251 |
0.802 |
|
| 2014 |
Jenkins MA, Wells G, Bachman J, Snyder JP, Jenkins A, Huganir RL, Oswald RE, Traynelis SF. Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840. Molecular Pharmacology. 85: 618-29. PMID 24452473 DOI: 10.1124/Mol.113.091488 |
0.798 |
|
| 2014 |
Ogden KK, Khatri A, Traynelis SF, Heldt SA. Potentiation of GluN2C/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 625-37. PMID 24008353 DOI: 10.1038/Npp.2013.241 |
0.844 |
|
| 2014 |
Ogden KK, Yuan H, Hansen KB, Zhang J, Gibb AJ, Traynelis SF. A Human Mutation in the M4 Helix of GluN2A Accelerates Forward Gating Transitions in NMDA Receptors Biophysical Journal. 106: 150a. DOI: 10.1016/J.Bpj.2013.11.863 |
0.857 |
|
| 2013 |
Kvist T, Steffensen TB, Greenwood JR, Mehrzad Tabrizi F, Hansen KB, Gajhede M, Pickering DS, Traynelis SF, Kastrup JS, Bräuner-Osborne H. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. The Journal of Biological Chemistry. 288: 33124-35. PMID 24072709 DOI: 10.1074/Jbc.M113.480210 |
0.715 |
|
| 2013 |
Kvist T, Greenwood JR, Hansen KB, Traynelis SF, Bräuner-Osborne H. Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. Neuropharmacology. 75: 324-36. PMID 23973313 DOI: 10.1016/J.Neuropharm.2013.08.003 |
0.744 |
|
| 2013 |
Acker TM, Khatri A, Vance KM, Slabber C, Bacsa J, Snyder JP, Traynelis SF, Liotta DC. Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. Journal of Medicinal Chemistry. 56: 6434-56. PMID 23909910 DOI: 10.1021/Jm400652R |
0.869 |
|
| 2013 |
Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC. Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. Journal of Medicinal Chemistry. 56: 5351-81. PMID 23627311 DOI: 10.1021/Jm400177T |
0.868 |
|
| 2013 |
Hansen KB, Tajima N, Risgaard R, Perszyk RE, Jørgensen L, Vance KM, Ogden KK, Clausen RP, Furukawa H, Traynelis SF. Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Molecular Pharmacology. 84: 114-27. PMID 23625947 DOI: 10.1124/Mol.113.085803 |
0.871 |
|
| 2013 |
Risgaard R, Nielsen SD, Hansen KB, Jensen CM, Nielsen B, Traynelis SF, Clausen RP. Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists. Journal of Medicinal Chemistry. 56: 4071-81. PMID 23614571 DOI: 10.1021/Jm400346A |
0.731 |
|
| 2013 |
Vance KM, Hansen KB, Traynelis SF. Modal gating of GluN1/GluN2D NMDA receptors. Neuropharmacology. 71: 184-90. PMID 23578394 DOI: 10.1016/J.Neuropharm.2013.03.018 |
0.866 |
|
| 2013 |
Gyoneva S, Traynelis SF. Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors. The Journal of Biological Chemistry. 288: 15291-302. PMID 23548902 DOI: 10.1074/Jbc.M113.458901 |
0.82 |
|
| 2013 |
Ogden KK, Traynelis SF. Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptors. Molecular Pharmacology. 83: 1045-56. PMID 23455314 DOI: 10.1124/Mol.113.085209 |
0.815 |
|
| 2013 |
Selvakumar B, Jenkins MA, Hussain NK, Huganir RL, Traynelis SF, Snyder SH. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America. 110: 1077-82. PMID 23277581 DOI: 10.1073/Pnas.1221295110 |
0.824 |
|
| 2012 |
Oh SJ, Han KS, Park H, Woo DH, Kim HY, Traynelis SF, Lee CJ. Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis. Molecular Brain. 5: 38. PMID 23062602 DOI: 10.1186/1756-6606-5-38 |
0.833 |
|
| 2012 |
Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC. Novel NMDA receptor modulators: an update. Expert Opinion On Therapeutic Patents. 22: 1337-52. PMID 23009122 DOI: 10.1517/13543776.2012.728587 |
0.869 |
|
| 2012 |
Vance KM, Hansen KB, Traynelis SF. GluN1 splice variant control of GluN1/GluN2D NMDA receptors. The Journal of Physiology. 590: 3857-75. PMID 22641781 DOI: 10.1113/Jphysiol.2012.234062 |
0.878 |
|
| 2012 |
Burger PB, Yuan H, Karakas E, Geballe M, Furukawa H, Liotta DC, Snyder JP, Traynelis SF. Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Molecular Pharmacology. 82: 344-59. PMID 22596351 DOI: 10.1124/Mol.112.078568 |
0.821 |
|
| 2012 |
Hansen KB, Ogden KK, Traynelis SF. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6197-208. PMID 22553026 DOI: 10.1523/Jneurosci.5757-11.2012 |
0.843 |
|
| 2012 |
Jenkins MA, Traynelis SF. PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance. Channels (Austin, Tex.). 6: 60-4. PMID 22373567 DOI: 10.4161/Chan.18648 |
0.747 |
|
| 2012 |
Wyllie DJ, Traynelis SF. NMDA receptor permeation: a light in the tunnel. Nature Neuroscience. 15: 343-4. PMID 22362102 DOI: 10.1038/nn.3058 |
0.726 |
|
| 2012 |
McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR. Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cellular Signalling. 24: 1351-60. PMID 22306780 DOI: 10.1016/J.Cellsig.2012.01.011 |
0.749 |
|
| 2012 |
Hedegaard M, Hansen KB, Andersen KT, Bräuner-Osborne H, Traynelis SF. Molecular pharmacology of human NMDA receptors. Neurochemistry International. 61: 601-9. PMID 22197913 DOI: 10.1016/J.Neuint.2011.11.016 |
0.749 |
|
| 2012 |
Hansen KB, Wollmuth LP, Traynelis SF. Structure-function correlates of glutamate-gated ion channels Comprehensive Biophysics. 6: 4-30. DOI: 10.1016/B978-0-12-374920-8.00611-1 |
0.563 |
|
| 2011 |
Ogden KK, Traynelis SF. New advances in NMDA receptor pharmacology. Trends in Pharmacological Sciences. 32: 726-33. PMID 21996280 DOI: 10.1016/J.Tips.2011.08.003 |
0.806 |
|
| 2011 |
Han KS, Mannaioni G, Hamill CE, Lee J, Junge CE, Lee CJ, Traynelis SF. Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus. Molecular Brain. 4: 32. PMID 21827709 DOI: 10.1186/1756-6606-4-32 |
0.826 |
|
| 2011 |
Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Molecular Pharmacology. 80: 782-95. PMID 21807990 DOI: 10.1124/Mol.111.073239 |
0.869 |
|
| 2011 |
Hansen KB, Traynelis SF. How glutamate receptor subunits mix and match: details uncovered. Neuron. 71: 198-200. PMID 21791278 DOI: 10.1016/J.Neuron.2011.07.008 |
0.71 |
|
| 2011 |
Vance KM, Simorowski N, Traynelis SF, Furukawa H. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nature Communications. 2: 294. PMID 21522138 DOI: 10.1038/Ncomms1295 |
0.866 |
|
| 2011 |
Kristensen AS, Jenkins MA, Banke TG, Schousboe A, Makino Y, Johnson RC, Huganir R, Traynelis SF. Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. Nature Neuroscience. 14: 727-35. PMID 21516102 DOI: 10.1038/Nn.2804 |
0.853 |
|
| 2011 |
Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 3650-61. PMID 21389220 DOI: 10.1523/Jneurosci.5565-10.2011 |
0.755 |
|
| 2011 |
Li F, Wang W, Gu M, Gyoneva S, Zhang J, Huang S, Traynelis SF, Cai H, Guggino SE, Zhang X. L-type calcium channel activity in osteoblast cells is regulated by the actin cytoskeleton independent of protein trafficking. Journal of Bone and Mineral Metabolism. 29: 515-25. PMID 21246227 DOI: 10.1007/S00774-010-0252-6 |
0.752 |
|
| 2010 |
Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM, Liotta DC, Traynelis SF. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nature Communications. 1: 90. PMID 20981015 DOI: 10.1038/Ncomms1085 |
0.885 |
|
| 2010 |
Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacological Reviews. 62: 405-96. PMID 20716669 DOI: 10.1124/Pr.109.002451 |
0.876 |
|
| 2010 |
Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. Journal of Medicinal Chemistry. 53: 5476-90. PMID 20684595 DOI: 10.1021/Jm100027P |
0.797 |
|
| 2010 |
Hansen KB, Furukawa H, Traynelis SF. Control of assembly and function of glutamate receptors by the amino-terminal domain. Molecular Pharmacology. 78: 535-49. PMID 20660085 DOI: 10.1124/Mol.110.067157 |
0.846 |
|
| 2010 |
McCoy KL, Traynelis SF, Hepler JR. PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Molecular Pharmacology. 77: 1005-15. PMID 20215560 DOI: 10.1124/Mol.109.062018 |
0.335 |
|
| 2010 |
Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, ... Traynelis SF, et al. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. The Journal of Pharmacology and Experimental Therapeutics. 333: 650-62. PMID 20197375 DOI: 10.1124/Jpet.110.166256 |
0.879 |
|
| 2010 |
Dravid SM, Burger PB, Prakash A, Geballe MT, Yadav R, Le P, Vellano K, Snyder JP, Traynelis SF. Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2741-54. PMID 20164358 DOI: 10.1523/Jneurosci.5390-09.2010 |
0.831 |
|
| 2010 |
Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, Almonte AG, Woo DH, Brat DJ, Hwang EM, Yoo SH, Chung CK, Park SH, Paek SH, Roh EJ, ... Traynelis SF, et al. Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Research. 70: 1173-83. PMID 20103623 DOI: 10.1158/0008-5472.Can-09-2886 |
0.8 |
|
| 2010 |
Hansen KB, Burger P, Vance KM, Snyder JP, Clausen RP, Traynelis SF. Subunit-Specific Activation of NMDA Receptors Biophysical Journal. 98: 525a-526a. DOI: 10.1016/J.Bpj.2009.12.2854 |
0.88 |
|
| 2010 |
Vance KM, Hansen KB, Ogden KK, Traynelis SF. Activation of Recombinant Rat GluN1/gluN2D NMDA Receptors Biophysical Journal. 98: 525a. DOI: 10.1016/J.Bpj.2009.12.2851 |
0.871 |
|
| 2010 |
Dravid SM, Yuan H, Traynelis SF. AMPA Receptors: Molecular Biology and Pharmacology Encyclopedia of Neuroscience. 311-318. DOI: 10.1016/B978-008045046-9.01221-3 |
0.81 |
|
| 2009 |
Gyoneva S, Orr AG, Traynelis SF. Differential regulation of microglial motility by ATP/ADP and adenosine. Parkinsonism & Related Disorders. 15: S195-9. PMID 20082989 DOI: 10.1016/S1353-8020(09)70813-2 |
0.816 |
|
| 2009 |
Wollmuth LP, Traynelis SF. Neuroscience: Excitatory view of a receptor. Nature. 462: 729-31. PMID 20010675 DOI: 10.1038/462729a |
0.557 |
|
| 2009 |
Park H, Oh SJ, Han KS, Woo DH, Park H, Mannaioni G, Traynelis SF, Lee CJ. Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13063-73. PMID 19828819 DOI: 10.1523/Jneurosci.3193-09.2009 |
0.811 |
|
| 2009 |
Yuan H, Hansen KB, Vance KM, Ogden KK, Traynelis SF. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12045-58. PMID 19793963 DOI: 10.1523/Jneurosci.1365-09.2009 |
0.876 |
|
| 2009 |
Mosley CA, Myers SJ, Murray EE, Santangelo R, Tahirovic YA, Kurtkaya N, Mullasseril P, Yuan H, Lyuboslavsky P, Le P, Wilson LJ, Yepes M, Dingledine R, Traynelis SF, Liotta DC. Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorganic & Medicinal Chemistry. 17: 6463-80. PMID 19648014 DOI: 10.1016/J.Bmc.2009.05.085 |
0.836 |
|
| 2009 |
Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nature Neuroscience. 12: 872-8. PMID 19525944 DOI: 10.1038/Nn.2341 |
0.7 |
|
| 2009 |
Hamill CE, Mannaioni G, Lyuboslavsky P, Sastre AA, Traynelis SF. Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function. Experimental Neurology. 217: 136-46. PMID 19416668 DOI: 10.1016/J.Expneurol.2009.01.023 |
0.856 |
|
| 2009 |
Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 12862-73. PMID 19240037 DOI: 10.1074/Jbc.M805123200 |
0.874 |
|
| 2009 |
Hansen KB, Naur P, Kurtkaya NL, Kristensen AS, Gajhede M, Kastrup JS, Traynelis SF. Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 907-17. PMID 19176800 DOI: 10.1523/Jneurosci.4081-08.2009 |
0.787 |
|
| 2009 |
Sivaprakasam M, Hansen KB, David O, Nielsen B, Traynelis SF, Clausen RP, Couty F, Bunch L. Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors. Chemmedchem. 4: 110-7. PMID 19009584 DOI: 10.1002/Cmdc.200800226 |
0.651 |
|
| 2009 |
Traynelis S, Orr A. O.093 Control of microglial motility by purinergic receptors Parkinsonism & Related Disorders. 15: S24-S25. DOI: 10.1016/S1353-8020(09)70108-7 |
0.7 |
|
| 2008 |
Ng FM, Geballe MT, Snyder JP, Traynelis SF, Low CM. Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Molecular Brain. 1: 16. PMID 19017396 DOI: 10.1186/1756-6606-1-16 |
0.436 |
|
| 2008 |
Tahirovic YA, Geballe M, Gruszecka-Kowalik E, Myers SJ, Lyuboslavsky P, Le P, French A, Irier H, Choi WB, Easterling K, Yuan H, Wilson LJ, Kotloski R, McNamara JO, Dingledine R, ... Traynelis SF, et al. Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. Journal of Medicinal Chemistry. 51: 5506-21. PMID 18800760 DOI: 10.1021/Jm8002153 |
0.855 |
|
| 2008 |
Dravid SM, Prakash A, Traynelis SF. Activation of recombinant NR1/NR2C NMDA receptors. The Journal of Physiology. 586: 4425-39. PMID 18635641 DOI: 10.1113/jphysiol.2008.158634 |
0.805 |
|
| 2008 |
Clausen RP, Christensen C, Hansen KB, Greenwood JR, Jørgensen L, Micale N, Madsen JC, Nielsen B, Egebjerg J, Bräuner-Osborne H, Traynelis SF, Kristensen JL. N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. Journal of Medicinal Chemistry. 51: 4179-87. PMID 18578474 DOI: 10.1021/Jm800025E |
0.721 |
|
| 2008 |
Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Berlinguer Palmini R, Junge CE, Lee CJ, Yepes M, Hepler JR, Traynelis SF. Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. The Journal of Biological Chemistry. 283: 20600-11. PMID 18474593 DOI: 10.1074/Jbc.M803015200 |
0.841 |
|
| 2008 |
Erreger K, Traynelis SF. Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors. The Journal of Physiology. 586: 763-78. PMID 18048453 DOI: 10.1113/Jphysiol.2007.143941 |
0.813 |
|
| 2008 |
Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Snyder JP, Traynelis SF, Wyllie DJ. Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. The Journal of Physiology. 586: 227-45. PMID 17962328 DOI: 10.1113/Jphysiol.2007.143172 |
0.853 |
|
| 2008 |
Yuan H, Geballe MT, Hansen KB, Traynelis SF. Structure and function of the NMDA receptor Structural and Functional Organization of the Synapse. 289-316. DOI: 10.1007/978-0-387-77232-5_11 |
0.793 |
|
| 2007 |
Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proceedings of the National Academy of Sciences of the United States of America. 104: 14116-21. PMID 17715062 DOI: 10.1073/Pnas.0703718104 |
0.839 |
|
| 2007 |
Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Molecular Pharmacology. 72: 907-20. PMID 17622578 DOI: 10.1124/Mol.107.037333 |
0.874 |
|
| 2007 |
Hamill CE, Caudle WM, Richardson JR, Yuan H, Pennell KD, Greene JG, Miller GW, Traynelis SF. Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1. Molecular Pharmacology. 72: 653-64. PMID 17596374 DOI: 10.1124/Mol.107.038158 |
0.813 |
|
| 2007 |
Almonte AG, Hamill CE, Chhatwal JP, Wingo TS, Barber JA, Lyuboslavsky PN, David Sweatt J, Ressler KJ, White DA, Traynelis SF. Learning and memory deficits in mice lacking protease activated receptor-1. Neurobiology of Learning and Memory. 88: 295-304. PMID 17544303 DOI: 10.1016/J.Nlm.2007.04.004 |
0.816 |
|
| 2007 |
Hansen KB, Yuan H, Traynelis SF. Structural aspects of AMPA receptor activation, desensitization and deactivation. Current Opinion in Neurobiology. 17: 281-8. PMID 17419047 DOI: 10.1016/J.Conb.2007.03.014 |
0.81 |
|
| 2007 |
Traynelis SF, Trejo J. Protease-activated receptor signaling: new roles and regulatory mechanisms. Current Opinion in Hematology. 14: 230-5. PMID 17414212 DOI: 10.1097/Moh.0B013E3280Dce568 |
0.483 |
|
| 2007 |
Lee CJ, Mannaioni G, Yuan H, Woo DH, Gingrich MB, Traynelis SF. Astrocytic control of synaptic NMDA receptors. The Journal of Physiology. 581: 1057-81. PMID 17412766 DOI: 10.1113/Jphysiol.2007.130377 |
0.869 |
|
| 2007 |
Dravid SM, Erreger K, Yuan H, Nicholson K, Le P, Lyuboslavsky P, Almonte A, Murray E, Mosely C, Barber J, French A, Balster R, Murray TF, Traynelis SF. Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. The Journal of Physiology. 581: 107-28. PMID 17303642 DOI: 10.1113/Jphysiol.2006.124958 |
0.836 |
|
| 2006 |
Paquet M, Asay MJ, Fam SR, Inuzuka H, Castleberry AM, Oller H, Smith Y, Yun CC, Traynelis SF, Hall RA. The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. The Journal of Biological Chemistry. 281: 29949-61. PMID 16891310 DOI: 10.1074/jbc.M602262200 |
0.624 |
|
| 2006 |
McBain CJ, Traynelis SF. Malevolent lurkers no more: NMDA receptors come of age. The Journal of Physiology. 575: 317-8. PMID 16809360 DOI: 10.1113/jphysiol.2006.114629 |
0.743 |
|
| 2006 |
Kristensen AS, Geballe MT, Snyder JP, Traynelis SF. Glutamate receptors: variation in structure-function coupling. Trends in Pharmacological Sciences. 27: 65-9. PMID 16406088 DOI: 10.1016/J.Tips.2005.12.005 |
0.737 |
|
| 2005 |
Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF. Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery. Clinical Neurosurgery. 52: 29-44. PMID 16626052 |
0.764 |
|
| 2005 |
Erreger K, Traynelis SF. Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors. The Journal of Physiology. 569: 381-93. PMID 16166158 DOI: 10.1113/Jphysiol.2005.095497 |
0.819 |
|
| 2005 |
Wong E, Ng FM, Yu CY, Lim P, Lim LH, Traynelis SF, Low CM. Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. Protein Science : a Publication of the Protein Society. 14: 2275-83. PMID 16131656 DOI: 10.1110/ps.051509905 |
0.6 |
|
| 2005 |
Erreger K, Geballe MT, Dravid SM, Snyder JP, Wyllie DJ, Traynelis SF. Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7858-66. PMID 16120788 DOI: 10.1523/Jneurosci.1613-05.2005 |
0.865 |
|
| 2005 |
Holm MM, Naur P, Vestergaard B, Geballe MT, Gajhede M, Kastrup JS, Traynelis SF, Egebjerg J. A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study. The Journal of Biological Chemistry. 280: 35469-76. PMID 16103115 DOI: 10.1074/Jbc.M507800200 |
0.574 |
|
| 2005 |
Holm MM, Lunn ML, Traynelis SF, Kastrup JS, Egebjerg J. Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. Proceedings of the National Academy of Sciences of the United States of America. 102: 12053-8. PMID 16099829 DOI: 10.1073/pnas.0505522102 |
0.477 |
|
| 2005 |
LePage KT, Ishmael JE, Low CM, Traynelis SF, Murray TF. Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptors. Neuropharmacology. 49: 1-16. PMID 15992576 DOI: 10.1016/J.Neuropharm.2005.01.029 |
0.445 |
|
| 2005 |
Kristensen AS, Traynelis SF. Neuroscience: an intrusive chaperone. Nature. 435: 1042-3. PMID 15973396 DOI: 10.1038/4351042A |
0.76 |
|
| 2005 |
Yuan H, Erreger K, Dravid SM, Traynelis SF. Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. The Journal of Biological Chemistry. 280: 29708-16. PMID 15970596 DOI: 10.1074/Jbc.M414215200 |
0.869 |
|
| 2005 |
Fam SR, Paquet M, Castleberry AM, Oller H, Lee CJ, Traynelis SF, Smith Y, Yun CC, Hall RA. P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proceedings of the National Academy of Sciences of the United States of America. 102: 8042-7. PMID 15901899 DOI: 10.1073/pnas.0408818102 |
0.615 |
|
| 2005 |
Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4319-29. PMID 15858058 DOI: 10.1523/Jneurosci.5200-04.2005 |
0.819 |
|
| 2005 |
Chen PE, Geballe MT, Stansfeld PJ, Johnston AR, Yuan H, Jacob AL, Snyder JP, Traynelis SF, Wyllie DJ. Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Molecular Pharmacology. 67: 1470-84. PMID 15703381 DOI: 10.1124/Mol.104.008185 |
0.839 |
|
| 2005 |
Erreger K, Dravid SM, Banke TG, Wyllie DJ, Traynelis SF. Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. The Journal of Physiology. 563: 345-58. PMID 15649985 DOI: 10.1113/Jphysiol.2004.080028 |
0.873 |
|
| 2005 |
Banke TG, Dravid SM, Traynelis SF. Protons trap NR1/NR2B NMDA receptors in a nonconducting state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 42-51. PMID 15634765 DOI: 10.1523/JNEUROSCI.3154-04.2005 |
0.788 |
|
| 2004 |
Erreger K, Chen PE, Wyllie DJ, Traynelis SF. Glutamate receptor gating. Critical Reviews in Neurobiology. 16: 187-224. PMID 15701057 DOI: 10.1615/Critrevneurobiol.V16.I3.10 |
0.856 |
|
| 2004 |
Olson EE, Lyuboslavsky P, Traynelis SF, McKeon RJ. PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 24: 964-71. PMID 15356417 DOI: 10.1097/01.Wcb.0000128266.87474.Bf |
0.337 |
|
| 2004 |
Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF. Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Experimental Neurology. 188: 94-103. PMID 15191806 DOI: 10.1016/J.Expneurol.2004.02.018 |
0.761 |
|
| 2004 |
Banke TG, Traynelis SF. Response to Gibb: NMDA receptor subunit gating – uncovered Trends in Neurosciences. 27: 10. DOI: 10.1016/J.TINS.2003.10.009 |
0.619 |
|
| 2003 |
Sorensen SD, Nicole O, Peavy RD, Montoya LM, Lee CJ, Murphy TJ, Traynelis SF, Hepler JR. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Molecular Pharmacology. 64: 1199-209. PMID 14573770 DOI: 10.1124/Mol.64.5.1199 |
0.59 |
|
| 2003 |
Junge CE, Sugawara T, Mannaioni G, Alagarsamy S, Conn PJ, Brat DJ, Chan PH, Traynelis SF. The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America. 100: 13019-24. PMID 14559973 DOI: 10.1073/Pnas.2235594100 |
0.736 |
|
| 2003 |
Jin R, Banke TG, Mayer ML, Traynelis SF, Gouaux E. Structural basis for partial agonist action at ionotropic glutamate receptors. Nature Neuroscience. 6: 803-10. PMID 12872125 DOI: 10.1038/Nn1091 |
0.555 |
|
| 2003 |
Low CM, Lyuboslavsky P, French A, Le P, Wyatte K, Thiel WH, Marchan EM, Igarashi K, Kashiwagi K, Gernert K, Williams K, Traynelis SF, Zheng F. Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Molecular Pharmacology. 63: 1212-22. PMID 12761330 DOI: 10.1124/mol.63.6.1212 |
0.526 |
|
| 2003 |
Bowie D, Garcia EP, Marshall J, Traynelis SF, Lange GD. Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins. The Journal of Physiology. 547: 373-85. PMID 12562952 DOI: 10.1113/Jphysiol.2002.033076 |
0.583 |
|
| 2003 |
Banke TG, Traynelis SF. Activation of NR1/NR2B NMDA receptors. Nature Neuroscience. 6: 144-52. PMID 12524545 DOI: 10.1038/nn1000 |
0.642 |
|
| 2003 |
Poisik OV, Mannaioni G, Traynelis S, Smith Y, Conn PJ. Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 122-30. PMID 12514208 DOI: 10.1523/Jneurosci.23-01-00122.2003 |
0.422 |
|
| 2001 |
Traynelis SF, Chesler M. Proton release as a modulator of presynaptic function. Neuron. 32: 960-2. PMID 11754826 DOI: 10.1016/S0896-6273(01)00549-9 |
0.377 |
|
| 2001 |
Mott DD, Erreger K, Banke TG, Traynelis SF. Open probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancy. The Journal of Physiology. 535: 427-43. PMID 11533135 DOI: 10.1111/J.1469-7793.2001.00427.X |
0.812 |
|
| 2001 |
Zheng F, Erreger K, Low CM, Banke T, Lee CJ, Conn PJ, Traynelis SF. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nature Neuroscience. 4: 894-901. PMID 11528420 DOI: 10.1038/Nn0901-894 |
0.836 |
|
| 2001 |
Mannaioni G, Marino MJ, Valenti O, Traynelis SF, Conn PJ. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5925-34. PMID 11487615 DOI: 10.1523/Jneurosci.21-16-05925.2001 |
0.44 |
|
| 2001 |
Banke TG, Greenwood JR, Christensen JK, Liljefors T, Traynelis SF, Schousboe A, Pickering DS. Identification of amino acid residues in GluR1 responsible for ligand binding and desensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3052-62. PMID 11312290 DOI: 10.1523/Jneurosci.21-09-03052.2001 |
0.365 |
|
| 2000 |
Low CM, Zheng F, Lyuboslavsky P, Traynelis SF. Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 11062-7. PMID 10984504 DOI: 10.1073/pnas.180307497 |
0.573 |
|
| 2000 |
Gingrich MB, Junge CE, Lyuboslavsky P, Traynelis SF. Potentiation of NMDA receptor function by the serine protease thrombin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4582-95. PMID 10844028 DOI: 10.1523/Jneurosci.20-12-04582.2000 |
0.833 |
|
| 2000 |
Banke TG, Bowie D, Lee H, Huganir RL, Schousboe A, Traynelis SF. Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 89-102. PMID 10627585 DOI: 10.1523/Jneurosci.20-01-00089.2000 |
0.635 |
|
| 1999 |
Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacological Reviews. 51: 7-61. PMID 10049997 |
0.747 |
|
| 1998 |
Mott DD, Doherty JJ, Zhang S, Washburn MS, Fendley MJ, Lyuboslavsky P, Traynelis SF, Dingledine R. Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition. Nature Neuroscience. 1: 659-67. PMID 10196581 DOI: 10.1038/3661 |
0.847 |
|
| 1998 |
Zheng F, Gingrich MB, Traynelis SF, Conn PJ. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nature Neuroscience. 1: 185-91. PMID 10195142 DOI: 10.1038/634 |
0.591 |
|
| 1998 |
Traynelis SF, Burgess MF, Zheng F, Lyuboslavsky P, Powers JL. Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6163-75. PMID 9698310 DOI: 10.1523/Jneurosci.18-16-06163.1998 |
0.542 |
|
| 1998 |
Wahl P, Anker C, Traynelis SF, Egebjerg J, Rasmussen JS, Krogsgaard-Larsen P, Madsen U. Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes. Molecular Pharmacology. 53: 590-6. PMID 9495827 DOI: 10.1124/Mol.53.3.590 |
0.526 |
|
| 1997 |
Traynelis SF, Wahl P. Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. The Journal of Physiology. 503: 513-31. PMID 9379408 DOI: 10.1111/j.1469-7793.1997.513bg.x |
0.459 |
|
| 1997 |
Chung DS, Traynelis SF, Murphy TJ, Conn PJ. 4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis. The Journal of Pharmacology and Experimental Therapeutics. 283: 742-9. PMID 9353394 |
0.387 |
|
| 1995 |
Traynelis SF, Hartley M, Heinemann SF. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science (New York, N.Y.). 268: 873-6. PMID 7754371 DOI: 10.1126/Science.7754371 |
0.717 |
|
| 1994 |
Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, Lipton SA. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron. 13: 929-36. PMID 7524561 DOI: 10.1016/0896-6273(94)90258-5 |
0.8 |
|
| 1994 |
Puchalski RB, Louis JC, Brose N, Traynelis SF, Egebjerg J, Kukekov V, Wenthold RJ, Rogers SW, Lin F, Moran T. Selective RNA editing and subunit assembly of native glutamate receptors. Neuron. 13: 131-47. PMID 7519023 DOI: 10.1016/0896-6273(94)90464-2 |
0.664 |
|
| 1993 |
Traynelis SF, Silver RA, Cull-Candy SG. Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse. Neuron. 11: 279-89. PMID 7688973 DOI: 10.1016/0896-6273(93)90184-S |
0.699 |
|
| 1993 |
Wyllie DJ, Traynelis SF, Cull-Candy SG. Evidence for more than one type of non-NMDA receptor in outside-out patches from cerebellar granule cells of the rat. The Journal of Physiology. 463: 193-226. PMID 7504104 DOI: 10.1113/jphysiol.1993.sp019591 |
0.792 |
|
| 1992 |
Miller B, Sarantis M, Traynelis SF, Attwell D. Potentiation of NMDA receptor currents by arachidonic acid. Nature. 355: 722-5. PMID 1371330 DOI: 10.1038/355722a0 |
0.596 |
|
| 1992 |
Silver RA, Traynelis SF, Cull-Candy SG. Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature. 355: 163-6. PMID 1370344 DOI: 10.1038/355163a0 |
0.679 |
|
| 1992 |
Wyllie DJA, Traynelis SF, Cull-Candy SG. Multiple non-NMDA glutamate receptors in rat cerebellar granule neurones in explant culture Journal of Physiology. 446: 178P. |
0.668 |
|
| 1992 |
Silver RA, Traynelis SF, Cull-Candy SG. Excitatory currents at the rat mossy fibre-granule cell synapse in thin cerebellar slices Journal of Physiology. 446: 177P. |
0.534 |
|
| 1991 |
Traynelis SF, Cull-Candy SG. Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. The Journal of Physiology. 433: 727-63. PMID 1726797 DOI: 10.1113/jphysiol.1991.sp018453 |
0.723 |
|
| 1990 |
McBain CJ, Traynelis SF, Dingledine R. Regional variation of extracellular space in the hippocampus. Science (New York, N.Y.). 249: 674-7. PMID 2382142 DOI: 10.1126/Science.2382142 |
0.662 |
|
| 1990 |
Kawasaki K, Traynelis SF, Dingledine R. Different responses of CA1 and CA3 regions to hypoxia in rat hippocampal slice. Journal of Neurophysiology. 63: 385-94. PMID 2158521 DOI: 10.1152/Jn.1990.63.3.385 |
0.544 |
|
| 1990 |
Traynelis SF, Cull-Candy SG. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature. 345: 347-50. PMID 1692970 DOI: 10.1038/345347a0 |
0.77 |
|
| 1990 |
Kawasaki K, Traynelis SF, Dingledine R. Epilepsy, human and experimentalHypoxia-induced different responses in CA1 and CA3 regions of the rat hippocampal slice Neuroscience Research Supplements. 11. DOI: 10.1016/0921-8696(90)90589-U |
0.508 |
|
| 1990 |
Kawasaki K, Traynelis SF, Dingledine R. Hypoxia-induced different responses in CA1 and CA3 regions of the rat hippocampal slice Neuroscience Research Supplements. 15: S45. DOI: 10.1016/0921-8696(90)90166-Z |
0.504 |
|
| 1990 |
McBain CJ, Traynelis SF, Dingledine R. The volume fraction of rat hippocampal extracellular space in vitro displays marked subfield variation Journal of Physiology. 426: 49P. |
0.606 |
|
| 1990 |
Cull-Candy SG, Traynelis SF. Proton inhibition of NMDA receptor-mediated responses in rat cultured cerebellar granule neurones Journal of Physiology. 423: 93P. |
0.65 |
|
| 1989 |
Traynelis SF, Dingledine R. Role of extracellular space in hyperosmotic suppression of potassium-induced electrographic seizures. Journal of Neurophysiology. 61: 927-38. PMID 2723735 DOI: 10.1152/Jn.1989.61.5.927 |
0.53 |
|
| 1989 |
Traynelis SF, Dingledine R, McNamara JO, Butler L, Rigsbee L. Effect of kindling on potassium-induced electrographic seizures in vitro. Neuroscience Letters. 105: 326-32. PMID 2594218 DOI: 10.1016/0304-3940(89)90642-3 |
0.51 |
|
| 1989 |
Traynelis SF, Dingledine R. Modification of potassium-induced interictal bursts and electrographic seizures by divalent cations. Neuroscience Letters. 98: 194-9. PMID 2565567 DOI: 10.1016/0304-3940(89)90509-0 |
0.571 |
|
| 1988 |
Traynelis SF, Dingledine R. Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. Journal of Neurophysiology. 59: 259-76. PMID 3343603 DOI: 10.1152/Jn.1988.59.1.259 |
0.531 |
|
| 1988 |
Dingledine R, Boland LM, Chamberlin NL, Kawasaki K, Kleckner NW, Traynelis SF, Verdoorn TA. Amino acid receptors and uptake systems in the mammalian central nervous system. Critical Reviews in Neurobiology. 4: 1-96. PMID 2461808 |
0.861 |
|
| 1985 |
Harden TK, Petch LA, Traynelis SF, Waldo GL. Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. The Journal of Biological Chemistry. 260: 13060-6. PMID 4055732 |
0.337 |
|
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