Stephen F. Traynelis - Related publications

Rollins Research Center Emory University, Atlanta, GA 
NMDA receptors, Rare Mutations, Epilepsy, Stroke
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Ahmed H, Haider A, Ametamey SM. -Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present). Expert Opinion On Therapeutic Patents. 1-25. PMID 32926646 DOI: 10.1080/13543776.2020.1811234   
2020 Glaser T, Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Bonfim Marques L, Ye Q, Ren WJ, Semyanov A, Illes P, Tang Y, Ulrich H. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. Neuroscience Bulletin. PMID 33026587 DOI: 10.1007/s12264-020-00582-8   
2020 Pollok S, Reiner A. Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proceedings of the National Academy of Sciences of the United States of America. 117: 25851-25858. PMID 32999066 DOI: 10.1073/pnas.2007471117   
2020 Rukavina Mikusic NL, Silva MG, Pineda AM, Gironacci MM. Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function? Frontiers in Pharmacology. 11: 1179. PMID 32848782 DOI: 10.3389/fphar.2020.01179   
2020 Ramesh S, Park S, Call MJ, Im W, Call ME. Experimentally Guided Computational Methods Yield Highly Accurate Insights into Transmembrane Interactions within the T Cell Receptor Complex. The Journal of Physical Chemistry. B. PMID 33030343 DOI: 10.1021/acs.jpcb.0c06403   
2020 Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Glaser T, Arnaud-Sampaio VF, Lameu C, Ulrich H. The P2X7 Receptor: Central Hub of Brain Diseases. Frontiers in Molecular Neuroscience. 13: 124. PMID 32848594 DOI: 10.3389/fnmol.2020.00124   
2020 Ellaithy A, Gonzalez-Maeso J, Logothetis DA, Levitz J. Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in Biochemical Sciences. PMID 32861513 DOI: 10.1016/j.tibs.2020.07.008   
2020 Zheng M, Zhang X, Min X, Sun N, Kim KM. Cytoplasmic recruitment of Mdm2 as a common characteristic of G protein-coupled receptors that undergo desensitization. Biochemical and Biophysical Research Communications. 530: 181-188. PMID 32828283 DOI: 10.1016/j.bbrc.2020.06.091   
2020 Silwal P, Paik S, Jeon SM, Jo EK. Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics. Cells. 9. PMID 32867365 DOI: 10.3390/cells9091979   
2020 Haruta-Tsukamoto A, Miyahara Y, Funahashi H, Nishimori T, Ishida Y. Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. Biochemical and Biophysical Research Communications. PMID 33028486 DOI: 10.1016/j.bbrc.2020.09.109   
2020 Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacological Reviews. 72: 910-968. PMID 32962984 DOI: 10.1124/pr.120.019331   
2020 Daya R, Ho J, Thomson S, Bhandari J, Mishra RK. The Effect of PAOPA, a Novel Allosteric Modulator of Dopamine D2 Receptors, on Select Signaling Proteins Following Sub-Chronic Administration in the Rat. Current Molecular Pharmacology. PMID 32912130 DOI: 10.2174/1874467213666200910091007   
2020 Saitoh Y, Katane M, Miyamoto T, Sekine M, Sakai-Kato K, Homma H. d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in via the NMDA Receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32855271 DOI: 10.1523/JNEUROSCI.2358-19.2020   
2020 Cifani C, Micioni Di Bonaventura E, Botticelli L, Del Bello F, Giorgioni G, Pavletić P, Piergentili A, Quaglia W, Bonifazi A, Schepmann D, Wünsch B, Vistoli G, Micioni Di Bonaventura MV. Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Blocking the Binge Eating Episode in Female Rats. Acs Chemical Neuroscience. PMID 32886484 DOI: 10.1021/acschemneuro.0c00456   
2020 Palma JA, Gupta A, Sierra S, Gomes I, Balgobin B, Norcliffe-Kaufmann L, Devi LA, Kaufmann H. Autoantibodies blocking M muscarinic receptors cause postganglionic cholinergic dysautonomia. Annals of Neurology. PMID 32833276 DOI: 10.1002/ana.25882   
2020 Greenfield DA, Schmidt HR, Skiba MA, Mandler MD, Anderson JR, Sliz P, Kruse AC. Virtual Screening for Ligand Discovery at the σ Receptor. Acs Medicinal Chemistry Letters. 11: 1555-1561. PMID 32832023 DOI: 10.1021/acsmedchemlett.9b00314   
2020 Agrawal S, He JC, Tharaux PL. Nuclear receptors in podocyte biology and glomerular disease. Nature Reviews. Nephrology. PMID 32943753 DOI: 10.1038/s41581-020-00339-6   
2020 Kukkonen JP. Allosteric interactions via the orthosteric ligand binding sites in a constitutive G-protein-coupled receptor homodimer. Pharmacological Research. 105116. PMID 32783977 DOI: 10.1016/j.phrs.2020.105116   
2020 Pieterse L, van der Walt MM, Terre'Blanche G. C2-substituted quinazolinone derivatives exhibit A and/or A adenosine receptor affinities in the low micromolar range. Bioorganic & Medicinal Chemistry Letters. 30: 127274. PMID 32631506 DOI: 10.1016/j.bmcl.2020.127274   
2020 Kozma MT, Ngo-Vu H, Rump MT, Bobkov YV, Ache BW, Derby CD. Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus. Bmc Genomics. 21: 649. PMID 32962631 DOI: 10.1186/s12864-020-07034-7   
2020 Hinnah K, Willems S, Morstein J, Heering J, Hartrampf F, Broichhagen J, Leippe P, Merk D, Trauner D. Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR). Journal of Medicinal Chemistry. PMID 32886507 DOI: 10.1021/acs.jmedchem.0c00654   
2020 Pandey S, Saha S, Shukla AK. Transmitting the Signal: Structure of the β1-Adrenergic Receptor-Gs Protein Complex. Molecular Cell. 80: 3-5. PMID 33007256 DOI: 10.1016/j.molcel.2020.09.016   
2020 Pandey S, Saha S, Shukla AK. Transmitting the Signal: Structure of the β1-Adrenergic Receptor-Gs Protein Complex. Molecular Cell. 80: 3-5. PMID 33007256 DOI: 10.1016/j.molcel.2020.09.016   
2020 Sharma M, Mittal A, Singh A, Jainarayanan AK, Sharma S, Paliwal S. Pharmacophore-driven identification of N-methyl-D-receptor antagonists as potent neuroprotective agents validated using studies. Biology Methods & Protocols. 5: bpaa013. PMID 32913897 DOI: 10.1093/biomethods/bpaa013   
2020 Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 30: 127501. PMID 32882418 DOI: 10.1016/j.bmcl.2020.127501   
2020 Gan Z, Cheng J, Chen S, Hou J, Li N, Xia H, Xia L, Lu Y, Nie P. Identification and characterization of tilapia CRFB1, CRFB2 and CRFB5 reveals preferential receptor usage of three IFN subtypes in perciform fishes. Fish & Shellfish Immunology. PMID 33011433 DOI: 10.1016/j.fsi.2020.10.002   
2020 Norton D, Pesce MS, Gill D. A Pounding Problem: A Case of Recurrent Headache Caused by Anti-NMDA Receptor Encephalitis. The Journal of Emergency Medicine. PMID 32917451 DOI: 10.1016/j.jemermed.2020.07.006   
2020 Senn L, Cannazza G, Biagini G. Receptors and Channels Possibly Mediating the Effects of Phytocannabinoids on Seizures and Epilepsy. Pharmaceuticals (Basel, Switzerland). 13. PMID 32751761 DOI: 10.3390/ph13080174   
2020 Shim Y, Kim SY, Kim H, Hwang H, Chae JH, Choi J, Kim KJ, Yum MS, Ko TS, Kim YO, Byeon JH, Lee J, Lee J, Kim JS, Lim BC. Clinical outcomes of pediatric Anti-NMDA receptor encephalitis. European Journal of Paediatric Neurology : Ejpn : Official Journal of the European Paediatric Neurology Society. PMID 33046392 DOI: 10.1016/j.ejpn.2020.10.001   
2020 Pereira PMR, Mandleywala K, Ragupathi A, Lewis JS. Acute statin treatment improves antibody accumulation in EGFR- and PSMA-expressing tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32998959 DOI: 10.1158/1078-0432.CCR-20-1960   
2020 Han X, Nieman MT. The domino effect triggered by the tethered ligand of the protease activated receptors. Thrombosis Research. 196: 87-98. PMID 32853981 DOI: 10.1016/j.thromres.2020.08.004   
2020 Hino N, Marumo T, Kotani M, Shimazaki T, Kaku-Fukumoto A, Hikichi H, Karasawa JI, Tomishima Y, Komiyama H, Tatsuda E, Nozawa D, Nakamura T, Chaki S. A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, Wake-Promoting and Pro-cognitive Effects in Rodents. The Journal of Pharmacology and Experimental Therapeutics. PMID 32862143 DOI: 10.1124/jpet.120.000185   
2020 Fernandez RW, Wei K, Wang EY, Mikalauskaite D, Olson A, Pepper J, Christie N, Kim S, Weissenborn S, Sarov M, Koelle MR. Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the Egg-Laying Circuit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32847964 DOI: 10.1523/JNEUROSCI.1357-20.2020   
2020 Kobayashi A, Azuma K, Ikeda K, Inoue S. Mechanisms Underlying the Regulation of Mitochondrial Respiratory Chain Complexes by Nuclear Steroid Receptors. International Journal of Molecular Sciences. 21. PMID 32932692 DOI: 10.3390/ijms21186683   
2020 Jacobson KA, Salmaso V. Purinergic signaling: Impact of GPCR structures on rational drug design. Chemmedchem. PMID 32803849 DOI: 10.1002/cmdc.202000465   
2020 Monrose M, Thirouard L, Garcia M, Holota H, De Haze A, Caira F, Beaudoin C, Volle DH. New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiology. Molecular Aspects of Medicine. 100886. PMID 32878696 DOI: 10.1016/j.mam.2020.100886   
2020 Gunera J, Baker JG, van Hilten N, Rosenbaum DM, Kolb P. Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. Journal of Medicinal Chemistry. PMID 32977721 DOI: 10.1021/acs.jmedchem.0c00964   
2020 Walsh KB, Andersen HK. Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling. International Journal of Molecular Sciences. 21. PMID 32854313 DOI: 10.3390/ijms21176115   
2020 Conte G, Nguyen NT, Alves M, de Diego-Garcia L, Kenny A, Nicke A, Henshall DC, Jimenez-Mateos EM, Engel T. P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice. Frontiers in Molecular Neuroscience. 13: 127. PMID 32982684 DOI: 10.3389/fnmol.2020.00127   
2020 Guo J, Han B, Wang J, Zhang L, Chen N, Sun W, Gao Y. The differential expression and potential roles of circular RNAs in children with anti-NMDA receptor encephalitis. Journal of Neuroimmunology. 348: 577381. PMID 32911360 DOI: 10.1016/j.jneuroim.2020.577381   
2020 Avgoustou P, Jailani ABA, Zirimwabagabo JO, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Bungay PJ, Wang N, Shaw AP, Bigos KJA, Holmes JL, Warrington JI, et al. Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor. Acs Pharmacology & Translational Science. 3: 706-719. PMID 32832872 DOI: 10.1021/acsptsci.0c00032   
2020 de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicology in Vitro : An International Journal Published in Association With Bibra. 104975. PMID 32858110 DOI: 10.1016/j.tiv.2020.104975   
2020 Sun X, Zhou R, Lei Y, Hu J, Li X. The ligand-gated ion channel P2X7 receptor mediates NLRP3/caspase-1-mediated pyroptosis in cerebral cortical neurons of juvenile rats with sepsis. Brain Research. 147109. PMID 32905819 DOI: 10.1016/j.brainres.2020.147109   
2020 Bernhard M, Laube B. Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs. Scientific Reports. 10: 16569. PMID 33024136 DOI: 10.1038/s41598-020-73157-2   
2020 Li Z, Luo W, Fang S, Chen X, Lin T, Zhou S, Zhang L, Yang W, Li Z, Jiantao Y, Junjian W, Liu P, Li Z. Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient. Acta Physiologica (Oxford, England). e13555. PMID 32886850 DOI: 10.1111/apha.13555   
2020 Mondritzki T, Mai TA, Vogel J, Pook E, Wasnaire P, Schmeck C, Hüser J, Dinh W, Truebel H, Kolkhof P. Cardiac output improvement by pecavaptan: A novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure. European Journal of Heart Failure. PMID 32946151 DOI: 10.1002/ejhf.2001   
2020 Chen J, Cai X, Yan M, Wang Z, Lv Z, Wang C. A method for identifying G protein-coupled receptor dimers and their interfaces. Biochimica Et Biophysica Acta. Molecular Cell Research. 118887. PMID 33075383 DOI: 10.1016/j.bbamcr.2020.118887   
2020 Jin Y, Qiu CY, Wei S, Han L, Liu TT, Hu WP. Potentiation of P2X3 receptor mediated currents by endothelin-1 in rat dorsal root ganglion neurons. Neuropharmacology. 108356. PMID 33069757 DOI: 10.1016/j.neuropharm.2020.108356   
2020 Althumairy D, Zhang X, Baez N, Barisas G, Roess DA, Bousfield GR, Crans DC. Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors. Diseases (Basel, Switzerland). 8. PMID 32942611 DOI: 10.3390/diseases8030035   
2020 González-Naranjo P, Pérez C, Girón R, Sánchez-Robles EM, Martín-Fontelles MI, Carrillo-López N, Martín-Vírgala J, Naves M, Campillo NE, Páez JA. New cannabinoid receptor antagonists as pharmacological tool. Bioorganic & Medicinal Chemistry. 28: 115672. PMID 32912440 DOI: 10.1016/j.bmc.2020.115672