| Year |
Citation |
Score |
| 2022 |
Murie M, Peng Y, Rigby MJ, Dieterich IA, Farrugia MA, Endresen A, Bhattacharyya A, Puglielli L. ATase inhibition rescues age-associated proteotoxicity of the secretory pathway. Communications Biology. 5: 173. PMID 35217767 DOI: 10.1038/s42003-022-03118-0 |
0.331 |
|
| 2021 |
Sheehan BK, Orefice NS, Peng Y, Shapiro SL, Puglielli L. ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1. Iscience. 24: 102315. PMID 33870132 DOI: 10.1016/j.isci.2021.102315 |
0.369 |
|
| 2021 |
Rigby MJ, Lawton AJ, Kaur G, Banduseela VC, Kamm WE, Lakkaraju A, Denu JM, Puglielli L. Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism. Communications Biology. 4: 454. PMID 33846551 DOI: 10.1038/s42003-021-01992-8 |
0.42 |
|
| 2021 |
Dieterich IA, Cui Y, Braun MM, Lawton AJ, Robinson NH, Peotter JL, Yu Q, Casler JC, Glick BS, Audhya A, Denu JM, Li L, Puglielli L. Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Scientific Reports. 11: 2013. PMID 33479349 DOI: 10.1038/s41598-021-81447-6 |
0.363 |
|
| 2020 |
Cooley MM, Thomas DDH, Deans K, Peng Y, Lugea A, Pandol SJ, Puglielli L, Groblewski GE. Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis. Cellular and Molecular Gastroenterology and Hepatology. PMID 33080365 DOI: 10.1016/j.jcmgh.2020.10.008 |
0.304 |
|
| 2020 |
Rigby MJ, Ding Y, Farrugia MA, Feig M, Cortese GP, Mitchell H, Burger C, Puglielli L. The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway. Journal of Neurochemistry. e14958. PMID 31945187 DOI: 10.1111/Jnc.14958 |
0.425 |
|
| 2019 |
Dieterich IA, Lawton AJ, Peng Y, Yu Q, Rhoads TW, Overmyer KA, Cui Y, Armstrong EA, Howell PR, Burhans MS, Li L, Denu JM, Coon JJ, Anderson RM, Puglielli L. Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk. Nature Communications. 10: 3929. PMID 31477734 DOI: 10.1038/S41467-019-11945-9 |
0.425 |
|
| 2019 |
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, ... ... Puglielli L, et al. Hypothalamic mTORC2 is essential for metabolic health and longevity. Aging Cell. e13014. PMID 31373126 DOI: 10.1111/Acel.13014 |
0.326 |
|
| 2018 |
Farrugia MA, Puglielli L. Nε-lysine acetylation in the endoplasmic reticulum - a novel cellular mechanism that regulates proteostasis and autophagy. Journal of Cell Science. 131. PMID 30446507 DOI: 10.1242/Jcs.221747 |
0.512 |
|
| 2018 |
Lu MH, Ji WL, Xu DE, Yao PP, Zhao XY, Wang ZT, Fang LP, Huang R, Lan LJ, Chen JB, Wang TH, Cheng LH, Xu RX, Liu CF, Puglielli L, et al. Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1. Experimental Neurology. PMID 30243987 DOI: 10.1016/J.Expneurol.2018.09.012 |
0.424 |
|
| 2018 |
Peng Y, Shapiro SL, Banduseela VC, Dieterich IA, Hewitt KJ, Bresnick EH, Kong G, Zhang J, Schueler KL, Keller MP, Attie AD, Hacker TA, Sullivan R, Kielar-Grevstad E, Arriola Apelo SI, ... ... Puglielli L, et al. Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype. Aging Cell. e12820. PMID 30051577 DOI: 10.1111/Acel.12820 |
0.433 |
|
| 2018 |
Martin SA, Souder DC, Miller KN, Clark JP, Sagar AK, Eliceiri KW, Puglielli L, Beasley TM, Anderson RM. GSK3β Regulates Brain Energy Metabolism. Cell Reports. 23: 1922-1931.e4. PMID 29768193 DOI: 10.1016/J.Celrep.2018.04.045 |
0.325 |
|
| 2017 |
Dieterich I, Yu Q, Overmyer K, Coon J, Li L, Puglielli L. METABOLIC CROSS-TALK BETWEEN ER, MITOCHONDRIA, AND NUCLEUS: POSSIBLE IMPACT IN AGING Innovation in Aging. 1: 256-256. DOI: 10.1093/Geroni/Igx004.939 |
0.318 |
|
| 2016 |
Hullinger R, Li M, Wang J, Peng Y, Dowell JA, Bomba-Warczak E, Mitchell HA, Burger C, Chapman ER, Denu JM, Li L, Puglielli L. Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation. The Journal of Experimental Medicine. PMID 27242167 DOI: 10.1084/Jem.20151776 |
0.415 |
|
| 2016 |
Peng Y, Puglielli L. Nϵ-lysine acetylation in the lumen of the endoplasmic reticulum: A way to regulate autophagy and maintain protein homeostasis in the secretory pathway. Autophagy. 1-2. PMID 27124586 DOI: 10.1080/15548627.2016.1164369 |
0.541 |
|
| 2016 |
Hoscheidt SM, Starks EJ, Oh JM, Zetterberg H, Blennow K, Krause RA, Gleason CE, Puglielli L, Atwood CS, Carlsson CM, Asthana S, Johnson SC, Bendlin BB. Insulin Resistance is Associated with Increased Alzheimer's Disease Pathology and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults. Journal of Alzheimer's Disease : Jad. PMID 27079723 DOI: 10.3233/Jad-160110 |
0.323 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Puglielli L, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.351 |
|
| 2016 |
Peng Y, Kim MJ, Hullinger R, O'Riordan KJ, Burger C, Pehar M, Puglielli L. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain : a Journal of Neurology. PMID 26787453 DOI: 10.1093/Brain/Awv385 |
0.482 |
|
| 2015 |
Li M, Pehar M, Liu Y, Bhattacharyya A, Zhang SC, O'Riordan KJ, Burger C, D'Adamio L, Puglielli L. The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism. Neurobiology of Aging. PMID 26174856 DOI: 10.1016/J.Neurobiolaging.2015.06.021 |
0.376 |
|
| 2015 |
Starks EJ, O'Grady JP, Hoscheidt SM, Racine AM, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Puglielli L, Asthana S, Dowling NM, Gleason CE, Anderson RM, Davenport-Sis NJ, DeRungs LM, et al. Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE ε4 Carriers. Journal of Alzheimer's Disease : Jad. PMID 25812851 DOI: 10.3233/Jad-150072 |
0.321 |
|
| 2014 |
Ding Y, Dellisanti CD, Ko MH, Czajkowski C, Puglielli L. The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides. The Journal of Biological Chemistry. 289: 32044-55. PMID 25301944 DOI: 10.1074/Jbc.M114.585547 |
0.438 |
|
| 2014 |
Mielke MM, Haughey NJ, Bandaru VV, Zetterberg H, Blennow K, Andreasson U, Johnson SC, Gleason CE, Blazel HM, Puglielli L, Sager MA, Asthana S, Carlsson CM. Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiology of Aging. 35: 2486-94. PMID 24952994 DOI: 10.1016/J.Neurobiolaging.2014.05.019 |
0.347 |
|
| 2014 |
Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L. Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6772-89. PMID 24828632 DOI: 10.1523/Jneurosci.0077-14.2014 |
0.43 |
|
| 2013 |
Westmark CJ, Berry-Kravis EM, Ikonomidou C, Yin JC, Puglielli L. Developing BACE-1 inhibitors for FXS. Frontiers in Cellular Neuroscience. 7: 77. PMID 23754978 DOI: 10.3389/Fncel.2013.00077 |
0.465 |
|
| 2013 |
Sridharan A, Pehar M, Salamat MS, Pugh TD, Bendlin BB, Willette AA, Anderson RM, Kemnitz JW, Colman RJ, Weindruch RH, Puglielli L, Johnson SC. Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study. Brain Research. 1508: 1-8. PMID 23473840 DOI: 10.1016/J.Brainres.2013.02.046 |
0.341 |
|
| 2013 |
Pehar M, Puglielli L. Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR. Biochimica Et Biophysica Acta. 1833: 686-97. PMID 23247107 DOI: 10.1016/J.Bbamcr.2012.12.004 |
0.52 |
|
| 2013 |
Mielke M, Haughey N, Vankata Ratnam Bandaru V, Zetterberg H, Johnson S, Gleason C, Blazel H, Puglielli L, Sager M, Asthana S, Carlsson C. P1-139: CSF sphingolipid levels correlate with CSF beta-amyloid and tau Alzheimer's & Dementia. 9: P200-P201. DOI: 10.1016/J.Jalz.2013.05.361 |
0.312 |
|
| 2012 |
Pehar M, Jonas MC, Hare TM, Puglielli L. SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway. The Journal of Biological Chemistry. 287: 29921-30. PMID 22787145 DOI: 10.1074/Jbc.M112.363911 |
0.729 |
|
| 2012 |
Pehar M, Lehnus M, Karst A, Puglielli L. Proteomic assessment shows that many endoplasmic reticulum (ER)-resident proteins are targeted by N(epsilon)-lysine acetylation in the lumen of the organelle and predicts broad biological impact. The Journal of Biological Chemistry. 287: 22436-40. PMID 22628546 DOI: 10.1074/Jbc.C112.362871 |
0.458 |
|
| 2012 |
Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L. Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation. The Journal of Biological Chemistry. 287: 8424-33. PMID 22267734 DOI: 10.1074/Jbc.M111.310136 |
0.429 |
|
| 2011 |
Bendlin B, Sodhi A, Willette A, Johnson S, Ries M, Hawley A, Alexander A, Puglielli L, Asthana S, Zetterberg H, Blennow K, Sager M. O2-01-07: Baseline cerebrospinal fluid markers in healthy middle-aged adults predict brain health at three-year follow-up Alzheimer's & Dementia. 7: e4-e4. DOI: 10.1016/J.Jalz.2011.09.012 |
0.353 |
|
| 2010 |
Jonas MC, Pehar M, Puglielli L. AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability. Journal of Cell Science. 123: 3378-88. PMID 20826464 DOI: 10.1242/Jcs.068841 |
0.74 |
|
| 2010 |
Pehar M, O'Riordan KJ, Burns-Cusato M, Andrzejewski ME, del Alcazar CG, Burger C, Scrable H, Puglielli L. Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death. Aging Cell. 9: 174-90. PMID 20409077 DOI: 10.1111/J.1474-9726.2010.00547.X |
0.349 |
|
| 2010 |
Bendlin BB, Carlsson CM, Gleason CE, Johnson SC, Sodhi A, Gallagher CL, Puglielli L, Engelman CD, Ries ML, Xu G, Wharton W, Asthana S. Midlife predictors of Alzheimer's disease. Maturitas. 65: 131-7. PMID 20044221 DOI: 10.1016/J.Maturitas.2009.12.014 |
0.311 |
|
| 2009 |
Ko MH, Puglielli L. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. The Journal of Biological Chemistry. 284: 2482-92. PMID 19011241 DOI: 10.1074/Jbc.M804901200 |
0.562 |
|
| 2009 |
Huttunen HJ, Puglielli L, Ellis BC, MacKenzie Ingano LA, Kovacs DM. Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells. Journal of Molecular Neuroscience : Mn. 37: 6-15. PMID 18618086 DOI: 10.1007/S12031-008-9088-0 |
0.469 |
|
| 2009 |
Li H, Costantini C, Scrable H, Weindruch R, Puglielli L. Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R. Neurobiology of Aging. 30: 2010-20. PMID 18378044 DOI: 10.1016/J.Neurobiolaging.2008.02.015 |
0.311 |
|
| 2008 |
Jonas MC, Costantini C, Puglielli L. PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1. Embo Reports. 9: 916-22. PMID 18660751 DOI: 10.1096/Fasebj.22.2_Supplement.220 |
0.749 |
|
| 2008 |
Carlsson CM, Gleason CE, Hess TM, Moreland KA, Blazel HM, Koscik RL, Schreiber NT, Johnson SC, Atwood CS, Puglielli L, Hermann BP, McBride PE, Stein JH, Sager MA, Asthana S. Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 13: 187-97. PMID 18376061 DOI: 10.3233/Jad-2008-13209 |
0.354 |
|
| 2008 |
Puglielli L. Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? Neurobiology of Aging. 29: 795-811. PMID 17313996 DOI: 10.1016/J.Neurobiolaging.2007.01.010 |
0.312 |
|
| 2008 |
Carlsson CM, Barnet J, Blazel HM, Puglielli L, Atwood CS, Gleason CE, Johnson SC, Sager MA, Asthana S. P3-062: Relationship of atherogenic lipid profiles and gender with CSF biomarkers in middle-aged adults at risk for Alzheimer's disease Alzheimer's & Dementia. 4: T535-T535. DOI: 10.1016/J.Jalz.2008.05.1626 |
0.314 |
|
| 2007 |
Ko MH, Puglielli L. The sterol carrier protein SCP-x/pro-SCP-2 gene has transcriptional activity and regulates the Alzheimer disease gamma-secretase. The Journal of Biological Chemistry. 282: 19742-52. PMID 17485462 DOI: 10.1074/Jbc.M611426200 |
0.336 |
|
| 2007 |
Costantini C, Ko MH, Jonas MC, Puglielli L. A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1. The Biochemical Journal. 407: 383-95. PMID 17425515 DOI: 10.1042/Bj20070040 |
0.747 |
|
| 2006 |
Costantini C, Scrable H, Puglielli L. An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. The Embo Journal. 25: 1997-2006. PMID 16619032 DOI: 10.1038/Sj.Emboj.7601062 |
0.383 |
|
| 2005 |
Costantini C, Kolasani RM, Puglielli L. Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified? Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 43-50. PMID 19595816 DOI: 10.1016/J.Jalz.2005.06.004 |
0.361 |
|
| 2005 |
Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. The Journal of Clinical Investigation. 115: 2556-63. PMID 16127459 DOI: 10.1172/Jci23610 |
0.402 |
|
| 2005 |
Costantini C, Weindruch R, Della Valle G, Puglielli L. A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging. The Biochemical Journal. 391: 59-67. PMID 15966860 DOI: 10.1042/Bj20050700 |
0.438 |
|
| 2004 |
Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 44: 227-38. PMID 15473963 DOI: 10.1016/J.Neuron.2004.08.043 |
0.407 |
|
| 2004 |
Puglielli L, Ellis BC, Ingano LA, Kovacs DM. Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. Journal of Molecular Neuroscience : Mn. 24: 93-6. PMID 15314256 DOI: 10.1385/Jmn:24:1:093 |
0.435 |
|
| 2003 |
Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nature Neuroscience. 6: 345-51. PMID 12658281 DOI: 10.1038/Nn0403-345 |
0.406 |
|
| 2003 |
Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. The Journal of Biological Chemistry. 278: 19777-83. PMID 12649271 DOI: 10.1074/Jbc.M300466200 |
0.469 |
|
| 2001 |
Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nature Cell Biology. 3: 905-12. PMID 11584272 DOI: 10.1038/Ncb1001-905 |
0.403 |
|
| 2000 |
Puglielli L, Konopka G, Mackenzie Ingano LA, Tanzi RE, Kovacs DM. Role of intracellular cholesterol compartmentation in APP processing and Aβgeneration Neurobiology of Aging. 21: 206. DOI: 10.1016/S0197-4580(00)83255-8 |
0.339 |
|
| 2000 |
Kovacs DM, Kovacs I, Lentini KM, Ingano LAM, Puglielli L, Tanzi RE. Effect of familial Alzheimer's disease mutations on the formation of presenilin aggregates in proteasome inhibitor treated cells Neurobiology of Aging. 21: 198. DOI: 10.1016/S0197-4580(00)82234-4 |
0.327 |
|
| 2000 |
MacKenzie Ingano LA, Lentini KM, Puglielli L, Tanzi RE, Kovacs DM. Presenilin 1 processing in cholesterol mutant cells treated with proteasome inhibitors Neurobiology of Aging. 21: 188. DOI: 10.1016/S0197-4580(00)82185-5 |
0.342 |
|
| 2000 |
Kovacs I, Lentini KM, MacKenzie Ingano LA, Puglielli L, Tanzi RE, Kovacs DM. Presenilin-containing aggresome formation in cholesterol mutant cells Neurobiology of Aging. 21: 185. DOI: 10.1016/S0197-4580(00)82172-7 |
0.33 |
|
| 1999 |
Puglielli L, Mandon EC, Rancour DM, Menon AK, Hirschberg CB. Identification and purification of the rat liver Golgi membrane UDP-N-acetylgalactosamine transporter. The Journal of Biological Chemistry. 274: 4474-9. PMID 9933652 DOI: 10.1074/Jbc.274.7.4474 |
0.36 |
|
| 1996 |
Puglielli L, Rigotti A, Amigo L, Nuñez L, Greco AV, Santos MJ, Nervi F. Modulation of intrahepatic cholesterol trafficking: evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile. Biochemical Journal. 317: 681-687. PMID 8760350 DOI: 10.1042/Bj3170681 |
0.353 |
|
| 1995 |
Puglielli L, Rigotti A, Greco AV, Santos MJ, Nervi F. Sterol Carrier Protein-2 Is Involved in Cholesterol Transfer from the Endoplasmic Reticulum to the Plasma Membrane in Human Fibroblasts Journal of Biological Chemistry. 270: 18723-18726. PMID 7642518 DOI: 10.1074/Jbc.270.32.18723 |
0.38 |
|
| 1995 |
Núñez L, Amigo L, Mingrone G, Rigotti A, Puglielli L, Raddatz A, Pimentel F, Greco AV, González S, Garrido J. Biliary aminopeptidase-N and the cholesterol crystallisation defect in cholelithiasis. Gut. 37: 422-426. PMID 7590442 DOI: 10.1136/Gut.37.3.422 |
0.304 |
|
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