Dave Morgan - Publications

Affiliations: 
University of South Florida, Tampa, FL, United States 
Area:
General, Neuroscience Biology, Pathology

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Finneran D, Li Q, Subbarayan MS, Joly-Amado A, Kamath S, Dengler DG, Gordon MN, Jackson MR, Morgan D, Bickford PC, Smith LH, Nash KR. Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1. Glia. PMID 36106533 DOI: 10.1002/glia.24269  0.473
2021 Loon A, Zamudio F, Sanneh A, Brown B, Smeltzer S, Brownlow ML, Quadri Z, Peters M, Weeber E, Nash K, Lee DC, Gordon MN, Morgan D, Selenica MB. Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. Geroscience. PMID 34410588 DOI: 10.1007/s11357-021-00408-z  0.816
2021 Ma C, Hunt JB, Kovalenko A, Liang H, Selenica MB, Orr MB, Zhang B, Gensel JC, Feola DJ, Gordon MN, Morgan D, Bickford PC, Lee DC. Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis. Frontiers in Immunology. 12: 628156. PMID 34046031 DOI: 10.3389/fimmu.2021.628156  0.815
2020 Ma C, Hunt JB, Selenica MB, Sanneh A, Sandusky-Beltran LA, Watler M, Daas R, Kovalenko A, Liang H, Placides D, Cao C, Lin X, Orr MB, Zhang B, Gensel JC, ... ... Morgan D, et al. Arginase 1 Insufficiency Precipitates Amyloid- Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis. Frontiers in Immunology. 11: 582998. PMID 33519806 DOI: 10.3389/fimmu.2020.582998  0.836
2020 Joly-Amado A, Hunter J, Quadri Z, Zamudio F, Rocha-Rangel PV, Chan D, Kesarwani A, Nash K, Lee DC, Morgan D, Gordon MN, Selenica MB. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in Immunology. 11: 997. PMID 32508844 DOI: 10.3389/fimmu.2020.00997  0.817
2019 Joly-Amado A, Davtyan H, Serraneau K, Jules P, Zitnyar A, Pressman E, Zagorski K, Antonyan T, Hovakimyan A, Paek HJ, Gordon MN, Cribbs DH, Petrovsky N, Agadjanyan MG, Ghochikyan A, ... Morgan D, et al. Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology. Neurobiology of Disease. 104636. PMID 31629891 DOI: 10.1016/J.Nbd.2019.104636  0.648
2019 Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, ... ... Morgan D, et al. Spermidine/spermine-N-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimer's Research & Therapy. 11: 58. PMID 31253191 DOI: 10.1186/S13195-019-0507-Y  0.795
2019 Tetlow AM, Joly-Amado A, Gordon MN, Morgan D. P4-158: CHANGES ACROSS THE LIFESPAN IN TG4510 MICE Alzheimer's & Dementia. 15: P1335-P1335. DOI: 10.1016/j.jalz.2019.06.3820  0.497
2019 Alhadidy MM, Soliman AS, Tetlow AM, Kara B, Kozikowski A, Gordon MN, Morgan D. P4-039: A Novel Histone Deacetylase 6 (Hdac6) Inhibitor To Mitigate Tau Pathology In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3698  0.5
2018 Finneran DJ, Morgan D, Gordon MN, Nash KR. CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 30499006 DOI: 10.1007/s11481-018-9822-5  0.567
2016 Joly-Amado A, Serraneau KS, Brownlow M, Marín de Evsikova C, Speakman JR, Gordon MN, Morgan D. Metabolic changes over the course of aging in a mouse model of tau deposition. Neurobiology of Aging. 44: 62-73. PMID 27318134 DOI: 10.1016/J.Neurobiolaging.2016.04.013  0.619
2016 He M, Singh P, Cheng S, Zhang Q, Peng W, Ding X, Li L, Liu J, Premont RT, Morgan D, Burns JM, Swerdlow RH, Suo WZ. GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability. Scientific Reports. 6: 26116. PMID 27193825 DOI: 10.1038/Srep26116  0.438
2016 Selenica MB, Reid P, Pena G, Alvarez J, Hunt JB, Nash KR, Morgan D, Gordon MN, Lee DC. Adeno associated viral-mediated intraosseous labeling of bone marrow derived cells for CNS tracking. Journal of Immunological Methods. PMID 26784524 DOI: 10.1016/J.Jim.2016.01.008  0.768
2015 Hunt JB, Nash KR, Placides D, Moran P, Selenica ML, Abuqalbeen F, Ratnasamy K, Slouha N, Rodriguez-Ospina S, Savlia M, Ranaweera Y, Reid P, Dickey CA, Uricia R, Yang CG, ... ... Morgan D, et al. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14842-60. PMID 26538654 DOI: 10.1523/Jneurosci.3959-14.2015  0.795
2015 Schroeder SK, Joly-Amado A, Gordon MN, Morgan D. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 26538351 DOI: 10.1007/S11481-015-9637-6  0.627
2015 Delic V, Brownlow M, Joly-Amado A, Zivkovic S, Noble K, Phan TA, Ta Y, Zhang Y, Bell SD, Kurien C, Reynes C, Morgan D, Bradshaw PC. Calorie restriction does not restore brain mitochondrial function in P301L tau mice, but it does decrease mitochondrial F0F1-ATPase activity. Molecular and Cellular Neurosciences. 67: 46-54. PMID 26048366 DOI: 10.1016/J.Mcn.2015.06.001  0.418
2015 Breydo L, Morgan D, Uversky VN. Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations. Molecular Neurobiology. PMID 25833100 DOI: 10.1007/S12035-015-9148-8  0.343
2015 Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, ... ... Morgan D, et al. Neuroinflammation in Alzheimer's disease. The Lancet. Neurology. 14: 388-405. PMID 25792098 DOI: 10.1016/S1474-4422(15)70016-5  0.399
2015 Woo JA, Boggess T, Uhlar C, Wang X, Khan H, Cappos G, Joly-Amado A, De Narvaez E, Majid S, Minamide LS, Bamburg JR, Morgan D, Weeber E, Kang DE. RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. Cell Death & Disease. 6: 1676. PMID 25741591 DOI: 10.1038/Cddis.2015.37  0.474
2015 Nash KR, Moran P, Finneran DJ, Hudson C, Robinson J, Morgan D, Bickford PC. Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 17-23. PMID 25195598 DOI: 10.1038/Mt.2014.175  0.369
2015 Haghighi M, Smith A, Morgan D, Small B, Huang S. Identifying cost-effective predictive rules of amyloid-β level by integrating neuropsychological tests and plasma-based markers. Journal of Alzheimer's Disease : Jad. 43: 1261-70. PMID 25147105 DOI: 10.3233/Jad-140705  0.379
2015 Sanneh A, Johnson N, Housley SB, Manchec B, Liu J, Nash K, Lee DC, Gordon MN, Morgan D, Selenica MB. Characterization of full length and c-terminal truncated tau pathological progression with age in wild type mice Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.873  0.599
2014 Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of Neuroinflammation. 11: 152. PMID 25183004 DOI: 10.1186/S12974-014-0152-0  0.826
2014 Joly-Amado A, Brownlow M, Pierce J, Ravipati A, Showalter E, Li Q, Gordon MN, Morgan D. Intraventricular human immunoglobulin distributes extensively but fails to modify amyloid in a mouse model of amyloid deposition. Current Alzheimer Research. 11: 664-71. PMID 25115543 DOI: 10.2174/1567205011666140812114341  0.669
2014 Brownlow ML, Joly-Amado A, Azam S, Elza M, Selenica ML, Pappas C, Small B, Engelman R, Gordon MN, Morgan D. Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition. Behavioural Brain Research. 271: 79-88. PMID 24925454 DOI: 10.1016/J.Bbr.2014.06.001  0.637
2014 Selenica ML, Benner L, Housley SB, Manchec B, Lee DC, Nash KR, Kalin J, Bergman JA, Kozikowski A, Gordon MN, Morgan D. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition. Alzheimer's Research & Therapy. 6: 12. PMID 24576665 DOI: 10.1186/Alzrt241  0.654
2013 Brownlow ML, Benner L, D'Agostino D, Gordon MN, Morgan D. Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. Plos One. 8: e75713. PMID 24069439 DOI: 10.1371/Journal.Pone.0075713  0.628
2013 Selenica ML, Alvarez JA, Nash KR, Lee DC, Cao C, Lin X, Reid P, Mouton PR, Morgan D, Gordon MN. Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain. Journal of Neuroinflammation. 10: 86. PMID 23866683 DOI: 10.1186/1742-2094-10-86  0.577
2013 Carty N, Nash KR, Brownlow M, Cruite D, Wilcock D, Selenica ML, Lee DC, Gordon MN, Morgan D. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. Plos One. 8: e59626. PMID 23555730 DOI: 10.1371/Journal.Pone.0059626  0.772
2013 Lee DC, Ruiz CR, Lebson L, Selenica ML, Rizer J, Hunt JB, Rojiani R, Reid P, Kammath S, Nash K, Dickey CA, Gordon M, Morgan D. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiology of Aging. 34: 1610-20. PMID 23481567 DOI: 10.1016/J.Neurobiolaging.2012.12.014  0.704
2013 Lee DC, Rizer J, Hunt JB, Selenica ML, Gordon MN, Morgan D. Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology. Neuropathology and Applied Neurobiology. 39: 69-85. PMID 23171029 DOI: 10.1111/Nan.12002  0.677
2013 Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D. Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. Neuro-Degenerative Diseases. 11: 165-81. PMID 22796753 DOI: 10.1159/000337230  0.764
2013 Nakamura M, Kaneko S, Ito H, Jiang S, Fujita K, Wate R, Nakano S, Fujisawa J, Kusaka H, Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, ... ... Morgan D, et al. Contents Vol. 11, 2013 Neurodegenerative Diseases. 11. DOI: 10.1159/000350668  0.587
2012 Li Q, Lebson L, Lee DC, Nash K, Grimm J, Rosenthal A, Selenica ML, Morgan D, Gordon MN. Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 202-14. PMID 22198698 DOI: 10.1007/S11481-011-9329-9  0.693
2011 Wilcock DM, Zhao Q, Morgan D, Gordon MN, Everhart A, Wilson JG, Lee JE, Colton CA. Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. Asn Neuro. 3: 249-58. PMID 21995345 DOI: 10.1042/An20110018  0.81
2011 Shineman DW, Basi GS, Bizon JL, Colton CA, Greenberg BD, Hollister BA, Lincecum J, Leblanc GG, Lee LB, Luo F, Morgan D, Morse I, Refolo LM, Riddell DR, Scearce-Levie K, et al. Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies. Alzheimer's Research & Therapy. 3: 28. PMID 21943025 DOI: 10.1186/Alzrt90  0.574
2011 Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA. Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. Journal of Neuroinflammation. 8: 115. PMID 21906275 DOI: 10.1186/1742-2094-8-115  0.761
2011 Morgan D. Immunotherapy for Alzheimer’s disease Journal of Internal Medicine. 269: 54-63. PMID 21158978 DOI: 10.1111/J.1365-2796.2010.02315.X  0.522
2011 Zhu Y, Obregon D, Hou H, Giunta B, Ehrhart J, Fernandez F, Mori T, Nikolic W, Zhao Y, Morgan D, Town T, Tan J. Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology. Journal of Cellular and Molecular Medicine. 15: 327-38. PMID 19900216 DOI: 10.1111/J.1582-4934.2009.00962.X  0.513
2010 Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of Neuroscience Methods. 194: 144-53. PMID 20951738 DOI: 10.1016/J.Jneumeth.2010.10.010  0.7
2010 Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of Neuroinflammation. 7: 56. PMID 20846376 DOI: 10.1186/1742-2094-7-56  0.841
2010 Lebson L, Nash K, Kamath S, Herber D, Carty N, Lee DC, Li Q, Szekeres K, Jinwal U, Koren J, Dickey CA, Gottschall PE, Morgan D, Gordon MN. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9651-8. PMID 20660248 DOI: 10.1523/Jneurosci.0329-10.2010  0.812
2010 Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE. Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. Journal of Neurochemistry. 113: 784-95. PMID 20180882 DOI: 10.1111/J.1471-4159.2010.06647.X  0.686
2010 Li QY, Gordon MN, Chackerian B, Alamed J, Ugen KE, Morgan D. Virus-like peptide vaccines against Abeta N-terminal or C-terminal domains reduce amyloid deposition in APP transgenic mice without addition of adjuvant. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 133-42. PMID 20066498 DOI: 10.1007/S11481-009-9183-1  0.598
2010 Williams EC, Toomey R, Gordon M, Williams D, Morgan D, Alcantar N. Abstract 3707: Design and characterization of a double packaged system for localized drug delivery for the treatment of cancers Cancer Research. 70: 3707-3707. DOI: 10.1158/1538-7445.Am10-3707  0.478
2010 Lee DC, Malthankar-Phatak G, Reid P, Alvarez J, Gordon MN, Siman R, Morgan D. P1-311: Differential response for amyloid clearance in APP Tg2576 mice and APP/PS1 double knockin mice following intracranial LPS Alzheimer's & Dementia. 6: S263-S263. DOI: 10.1016/J.Jalz.2010.05.864  0.634
2010 Alcantar NA, Jimenez J, Morgan D. P1-255: Direct observation of the kinetic mechanisms for Aß peptide aggregation: Towards elucidating Alzheimer plaque dissolution Alzheimer's & Dementia. 6: S247-S247. DOI: 10.1016/J.Jalz.2010.05.807  0.371
2010 Selenica MB, Nash K, Lee DC, Morgan D, Gordon MN. Brain infiltration of peripheral monocytes via AAV-9 driven chemokine overexpression Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1820  0.499
2010 Nash KR, Brownlow M, Carty N, Cruite D, Selenica M, Gordon M, Morgan D. P3-305: Long-term reduction of Aβ deposits in APP + PS1 transgenic mice via adeno-associated viral vector mediated gene delivery of neprilysin Alzheimer's & Dementia. 6: S541-S541. DOI: 10.1016/J.Jalz.2010.05.1806  0.62
2009 Morgan D. The role of microglia in antibody-mediated clearance of amyloid-beta from the brain. Cns & Neurological Disorders Drug Targets. 8: 7-15. PMID 19275633 DOI: 10.2174/187152709787601821  0.496
2009 Lord A, Englund H, Söderberg L, Tucker S, Clausen F, Hillered L, Gordon M, Morgan D, Lannfelt L, Pettersson FE, Nilsson LN. Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice. The Febs Journal. 276: 995-1006. PMID 19215301 DOI: 10.1111/J.1742-4658.2008.06836.X  0.671
2009 Morgan D, Landreth G, Bickford P. The promise and perils of an Alzheimer disease vaccine: A video debate Journal of Neuroimmune Pharmacology. 4: 1-3. PMID 18946741 DOI: 10.1007/S11481-008-9132-4  0.46
2009 Dickey CA, Jinwal UK, Koren J, O'Leary J, Anderson L, Jones J, Shults C, Jin Y, Johnson A, Abisambra J, Morgan D, Lee DC, Chang L, Miyata Y, Thompson A, et al. P2-198: Chemical manipulation of Hsp70 activity regulates tau processing Alzheimer's & Dementia. 5: P319-P319. DOI: 10.1016/J.Jalz.2009.04.510  0.777
2009 Jimenez J, Morgan D, Kobayashi D, Alcantar N. Altering the Process of Aß-Plaque Formation: Effect of Monoclonal Antibodies Biophysical Journal. 96: 587a. DOI: 10.1016/J.Bpj.2008.12.3071  0.447
2008 Li Q, Gordon M, Etienne MA, Hammer RP, Morgan D. Contrasting In Vivo Effects of Two Peptide-Based Amyloid-β Protein Aggregation Inhibitors in a Transgenic Mouse Model of Amyloid Deposition. Cell Transplantation. 17: 397-408. PMID 28863742 DOI: 10.3727/096368908784423247  0.617
2008 Carty NC, Nash K, Lee D, Mercer M, Gottschall PE, Meyers C, Muzyczka N, Gordon MN, Morgan D. Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1580-1586. PMID 28189012 DOI: 10.1038/Mt.2008.148  0.733
2008 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Journal of Alzheimer's Disease : Jad. 15: 605-14. PMID 19096159 DOI: 10.3233/Jad-2008-15407  0.724
2008 Carty NC, Nash K, Lee D, Mercer M, Gottschall PE, Meyers C, Muzyczka N, Gordon MN, Morgan D. Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1580-6. PMID 18665160 DOI: 10.1038/mt.2008.148  0.705
2008 Karlnoski RA, Rosenthal A, Alamed J, Ronan V, Gordon MN, Gottschall PE, Grimm J, Pons J, Morgan D. Deglycosylated anti-Abeta antibody dose-response effects on pathology and memory in APP transgenic mice. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 3: 187-97. PMID 18607758 DOI: 10.1007/S11481-008-9114-6  0.646
2008 Li Q, Gordon M, Etienne MA, Hammer RP, Morgan D. Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition. Cell Transplantation. 17: 397-408. PMID 18522242 DOI: 10.3727/096368908784423247  0.644
2008 Morgan D, Gordon MN. Amyloid, hyperactivity, and metabolism: theoretical comment on Vloeberghs et al. (2008). Behavioral Neuroscience. 122: 730-2. PMID 18513144 DOI: 10.1037/0735-7044.122.3.730  0.635
2008 Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3622-7. PMID 18292230 DOI: 10.1073/Pnas.0709180105  0.748
2008 Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J. CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation. Neurobiology of Disease. 29: 336-53. PMID 18055209 DOI: 10.1016/J.Nbd.2007.09.009  0.475
2008 Lord A, Englund H, Clausen F, Hillered L, Pettersson FE, Gordon M, Morgan D, Lannfelt L, Nilsson LN. O3-01-01: Amyloid-β protofibrils are linked to cognitive impairment in Alzheimer's disease transgenic mice Alzheimer's & Dementia. 4: T157-T157. DOI: 10.1016/J.Jalz.2008.05.405  0.62
2008 Dickey CA, Koren J, Zhang Y, Xu Y, Jinwal U, Bailey R, Dunmore J, Birnbaum M, Morgan D, Petrucelli L. O1-06-03: Akt functions to regulate the chaperone complex and attenuate Tau degradation Alzheimer's & Dementia. 4: T120-T120. DOI: 10.1016/J.Jalz.2008.05.258  0.695
2008 Morgan D. S1-03-01: Inflammation signaling mechanisms in Alzheimer's Disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.197  0.324
2008 Lee DC, Gordon M, Morgan D. P3-365: Polarization of microglia modifies amyloid pathology in APP Tg2576 mice Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1935  0.636
2008 Carty NC, Meyers C, Nash K, Muzyckza N, Gordon MN, Morgan D. P2-425: Systemic mannitol administration with convection enhanced delivery of rAAV increases area of gene distribution and uptake in mouse hippocampus Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1504  0.483
2008 Li Q, Gordon MN, Chackerian B, Alamed J, Ugen KE, Morgan D. P2-342: Vaccination of amyloid precursor protein transgenic mice with a bacteriophage-based short amyloid-β peptide vaccines without adjuvant induce a strong Th2-type anti-amyloid-β IgG and IgM response and reduce amyloid-β burden Alzheimer's & Dementia. 4: T473-T473. DOI: 10.1016/J.Jalz.2008.05.1419  0.598
2007 Herber DL, Mercer M, Roth LM, Symmonds K, Maloney J, Wilson N, Freeman MJ, Morgan D, Gordon MN. Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 222-31. PMID 18040847 DOI: 10.1007/S11481-007-9069-Z  0.622
2007 Morgan D. Amyloid, memory and neurogenesis. Experimental Neurology. 205: 330-5. PMID 17445801 DOI: 10.1016/J.Expneurol.2007.03.006  0.441
2007 Li Q, Gordon M, Cao C, Ugen KE, Morgan D. Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies. Bmc Neuroscience. 8: 22. PMID 17374155 DOI: 10.1186/1471-2202-8-22  0.587
2007 Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proceedings of the National Academy of Sciences of the United States of America. 104: 2507-12. PMID 17264212 DOI: 10.1073/Pnas.0609377104  0.486
2007 Wilcock DM, Jantzen PT, Li Q, Morgan D, Gordon MN. Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience. 144: 950-60. PMID 17137722 DOI: 10.1016/J.Neuroscience.2006.10.020  0.733
2007 Karlnoski R, Wilcock D, Dickey C, Ronan V, Gordon MN, Zhang W, Morgan D, Taglialatela G. Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection Neurobiology of Disease. 25: 179-188. PMID 17067805 DOI: 10.1016/J.Nbd.2006.09.007  0.806
2007 Rojiani AM, Ambegaoankar M, Gordon MN, Breitner JCS, Morgan D. The H-2 receptor antagonist cimetidine blocks kainic acid toxicity in hippocampus as effectively as the NMDA receptor antagonist MK-801: 40.8 Journal of Neuropathology and Experimental Neurology. 66: 420. DOI: 10.1097/01.Jnen.0000268982.06535.5E  0.437
2007 Rojiani AM, Ambegaoankar M, Gordon MN, Breitner JCS, Morgan D. The H-2 Receptor Antagonist Cimetidine Blocks Kainic Acid Toxicity in Hippocampus as Effectively as the NMDA Receptor Antagonist MK-801 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A20-B  0.437
2007 Morgan D. The rationale for an immunological approach to Alzheimer's therapeutics Pharmacological Mechanisms in Alzheimer's Therapeutics. 141-148. DOI: 10.1007/978-0-387-71522-3_9  0.336
2006 Alamed J, Wilcock DM, Diamond DM, Gordon MN, Morgan D. Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice. Nature Protocols. 1: 1671-9. PMID 17487150 DOI: 10.1038/Nprot.2006.275  0.672
2006 Wilcock DM, Gordon MN, Morgan D. Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain. Nature Protocols. 1: 1591-5. PMID 17406451 DOI: 10.1038/Nprot.2006.277  0.733
2006 Morgan D. Immunotherapy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 9: 425-32. PMID 16914881 DOI: 10.3233/Jad-2006-9S348  0.51
2006 Morgan D. Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice. Neurochemistry International. 49: 190-4. PMID 16740342 DOI: 10.1016/J.Neuint.2006.03.017  0.558
2006 Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, Ronan V, Symmonds K, Gordon MN, Morgan D. Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5340-6. PMID 16707786 DOI: 10.1523/Jneurosci.0695-06.2006  0.754
2006 Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D. Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. Journal of Neuroinflammation. 3: 11. PMID 16686956 DOI: 10.1186/1742-2094-3-11  0.737
2006 Herber DL, Maloney JL, Roth LM, Freeman MJ, Morgan D, Gordon MN. Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia. 53: 382-91. PMID 16288481 DOI: 10.1002/Glia.20272  0.533
2006 Tetlow AM, Joly-Amado A, Gordon MN, Morgan D. P3‐176: AGE AS A PREDICTOR OF DIFFERENT PHYSIOLOGICAL FORMS OF TAU Alzheimer's & Dementia. 14. DOI: 10.1016/j.jalz.2018.06.1534  0.479
2006 Lutz L, Mercer M, Freeman M, Ronan V, Wilcock D, Herber D, Gordon M, Morgan D. Phenotyping the microglial response using different activators in mouse CNS Experimental Neurology. 198: 579. DOI: 10.1016/J.Expneurol.2006.02.067  0.654
2006 Li Q, Gordon M, Tan J, Morgan D. Oral administration of green tea epigallocatechin-3-gallate (EGCG) reduces amyloid beta deposition in transgenic mouse model of Alzheimer's disease Experimental Neurology. 198: 576. DOI: 10.1016/J.Expneurol.2006.02.062  0.62
2006 Karlnoski R, Ronan V, Gordon M, Gottschall P, Rosenthal A, Grimm J, Morgan D. Low doses of deglycosylated anti-Aβ antibodies reduce amyloid pathology and reverse cognitive deficits in old app transgenic mice Experimental Neurology. 198: 573. DOI: 10.1016/J.Expneurol.2006.02.053  0.644
2006 Carty N, Ronan V, Meyers C, Nash K, Muzyckza N, Gordon M, Morgan D. AAV vector mediated gene delivery of endothelin converting enzyme-1 reduces β-amyloid deposits in transgenic APP + PS1 mice Experimental Neurology. 198: 562. DOI: 10.1016/J.Expneurol.2006.02.027  0.618
2005 Morgan D. Mechanisms of A beta plaque clearance following passive A beta immunization. Neuro-Degenerative Diseases. 2: 261-6. PMID 16909007 DOI: 10.1159/000090366  0.418
2005 Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. Journal of Neuropathology and Experimental Neurology. 64: 743-53. PMID 16141783 DOI: 10.1097/01.Jnen.0000178444.33972.E0  0.763
2005 Dickey CA, Gordon MN, Wilcock DM, Herber DL, Freeman MJ, Morgan D. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. Bmc Neuroscience. 6: 7. PMID 15689237 DOI: 10.1186/1471-2202-6-7  0.789
2004 Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, Morgan D. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. Journal of Neuroinflammation. 1: 24. PMID 15588287 DOI: 10.1186/1742-2094-1-24  0.784
2004 Herber DL, Roth LM, Wilson D, Wilson N, Mason JE, Morgan D, Gordon MN. Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice. Experimental Neurology. 190: 245-53. PMID 15473997 DOI: 10.1016/J.Expneurol.2004.07.007  0.613
2004 Herber DL, Severance EG, Cuevas J, Morgan D, Gordon MN. Biochemical and histochemical evidence of nonspecific binding of α7nAChR antibodies to mouse brain tissue Journal of Histochemistry and Cytochemistry. 52: 1367-1375. PMID 15385583 DOI: 10.1177/002215540405201013  0.539
2004 Dickey CA, De Mesquita DD, Morgan D, Pennypacker KR. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neuroscience Letters. 366: 10-4. PMID 15265580 DOI: 10.1016/J.Neulet.2004.04.089  0.554
2004 Wilcock DM, Rojiani A, Rosenthal A, Levkowitz G, Subbarao S, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, Morgan D. Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6144-51. PMID 15240806 DOI: 10.1523/Jneurosci.1090-04.2004  0.757
2004 Li Q, Cao C, Chackerian B, Schiller J, Gordon M, Ugen KE, Morgan D. Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice. Bmc Neuroscience. 5: 21. PMID 15186505 DOI: 10.1186/1471-2202-5-21  0.63
2004 Morgan D, Gitter BD. Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease. Neurobiology of Aging. 25: 605-8. PMID 15172737 DOI: 10.1016/J.Neurobiolaging.2004.02.005  0.527
2004 Garcia MF, Gordon MN, Hutton M, Lewis J, McGowan E, Dickey CA, Morgan D, Arendash GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15: 73-7. PMID 15106834 DOI: 10.1097/00001756-200401190-00015  0.73
2004 Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, Morgan D. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiology of Disease. 15: 11-20. PMID 14751766 DOI: 10.1016/J.Nbd.2003.09.015  0.736
2004 Dickey CA, Gordon MN, Mason JE, Wilson NJ, Diamond DM, Guzowski JF, Morgan D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. Journal of Neurochemistry. 88: 434-42. PMID 14690531 DOI: 10.1111/J.1471-4159.2004.02185.X  0.773
2004 Wilcock DM, Rojiani A, Rosenthal A, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, Morgan D. P4-366 Passive immunization with anti-Aβ antibodies reduces amyloid burden while producing a brief activation of microglia in a transgenic mouse model of amyloid deposition Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81924-9  0.75
2004 Herber DL, Roth LM, Freeman MJ, Morgan D, Gordon MN. P4-227 Lipopolysaccharide as a neuroinflammatory agent: evaluation of the time course of inflammatory markers using quantitative real time PCR, behavioral outcomes, and immunohistochemistry Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81785-8  0.449
2003 Morgan D. Antibody therapy for Alzheimer's disease. Expert Review of Vaccines. 2: 53-9. PMID 12901597 DOI: 10.1586/14760584.2.1.53  0.365
2003 Dickey CA, Loring JF, Montgomery J, Gordon MN, Eastman PS, Morgan D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5219-26. PMID 12832546 DOI: 10.1523/Jneurosci.23-12-05219.2003  0.753
2003 Austin L, Arendash GW, Gordon MN, Diamond DM, DiCarlo G, Dickey C, Ugen K, Morgan D. Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice. Behavioral Neuroscience. 117: 478-84. PMID 12802876 DOI: 10.1037/0735-7044.117.3.478  0.701
2003 Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutritional Neuroscience. 6: 153-62. PMID 12793519 DOI: 10.1080/1028415031000111282  0.597
2003 Morgan D. Learning and memory deficits in APP transgenic mouse models of amyloid deposition. Neurochemical Research. 28: 1029-34. PMID 12737527 DOI: 10.1023/A:1023255106106  0.46
2003 Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3745-51. PMID 12736345  0.726
2003 Boyett KW, DiCarlo G, Jantzen PT, Jackson J, O'Leary C, Wilcock D, Morgan D, Gordon MN. Increased fibrillar beta-amyloid in response to human clq injections into hippocampus and cortex of APP+PS1 transgenic mice. Neurochemical Research. 28: 83-93. PMID 12587666 DOI: 10.1023/A:1021600212829  0.767
2003 Kassed CA, Butler TL, Navidomskis MT, Gordon MN, Morgan D, Pennypacker KR. Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-kappaB p50 in hippocampal neurons after injury. Brain Research. Molecular Brain Research. 110: 152-7. PMID 12573544 DOI: 10.1016/S0169-328X(02)00658-7  0.59
2003 Morgan D, Jantzen P, Wilcock D, DiCarlo G, Ugen K, Gordon M. The Association of Microglial Activation and Amyloid Reduction in APP+PS1 Transgenic Mice Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3: 27-32. DOI: 10.2174/1568013033358680  0.765
2003 Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D. Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation The Journal of Neuroscience. 23: 3745-3751. DOI: 10.1523/Jneurosci.23-09-03745.2003  0.745
2002 Morgan D, Keller RK. What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 4: 257-60. PMID 12226546 DOI: 10.3233/Jad-2002-4317  0.485
2002 Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN. Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2246-54. PMID 11896164 DOI: 10.1523/Jneurosci.22-06-02246.2002  0.674
2002 Gordon MN, Holcomb LA, Jantzen PT, DiCarlo G, Wilcock D, Boyett KW, Connor K, Melachrino J, O'Callaghan JP, Morgan D. Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Experimental Neurology. 173: 183-95. PMID 11822882 DOI: 10.1006/Exnr.2001.7754  0.736
2001 Arendash GW, Gordon MN, Diamond DM, Austin LA, Hatcher JM, Jantzen P, DiCarlo G, Wilcock D, Morgan D. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. Dna and Cell Biology. 20: 737-44. PMID 11788052 DOI: 10.1089/10445490152717604  0.736
2001 Wilcock DM, Gordon MN, Ugen KE, Gottschall PE, DiCarlo G, Dickey C, Boyett KW, Jantzen PT, Connor KE, Melachrino J, Hardy J, Morgan D. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. Dna and Cell Biology. 20: 731-6. PMID 11788051 DOI: 10.1089/10445490152717596  0.804
2001 Ugen KE, Morgan D. Alzheimer's disease: Molecularly based immunotherapeutics Dna and Cell Biology. 20: 677-678. PMID 11788044 DOI: 10.1089/10445490152717523  0.363
2001 DiCarlo G, Wilcock D, Henderson D, Gordon M, Morgan D. Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. Neurobiology of Aging. 22: 1007-12. PMID 11755009 DOI: 10.1016/S0197-4580(01)00292-5  0.734
2001 Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ. Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway. Experimental Neurology. 170: 227-43. PMID 11476589 DOI: 10.1006/Exnr.2001.7710  0.669
2001 Gordon MN, King DL, Diamond DM, Jantzen PT, Boyett KV, Hope CE, Hatcher JM, DiCarlo G, Gottschall WP, Morgan D, Arendash GW. Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice. Neurobiology of Aging. 22: 377-85. PMID 11378242 DOI: 10.1016/S0197-4580(00)00249-9  0.636
2001 Arendash GW, King DL, Gordon MN, Morgan D, Hatcher JM, Hope CE, Diamond DM. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Research. 891: 42-53. PMID 11164808 DOI: 10.1016/S0006-8993(00)03186-3  0.669
2001 Morgan D. The intersection of Alzheimer's disease and typical aging. Neurobiology of Aging. 22: 159-160. PMID 11164292 DOI: 10.1016/S0197-4580(00)00208-6  0.357
2001 Nilsson LNG, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H. α-1-Antichymotrypsin Promotes β-Sheet Amyloid Plaque Deposition in a Transgenic Mouse Model of Alzheimer's Disease The Journal of Neuroscience. 21: 1444-1451. DOI: 10.1523/Jneurosci.21-05-01444.2001  0.689
2001 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. Erratum: correction: Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature. 412: 660-660. DOI: 10.1038/35088102  0.754
2000 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408: 982-5. PMID 11140686 DOI: 10.1038/35050116  0.787
2000 Morgan D, Gordon MN, Diamond D, King D, Arendash G. Age-related memory deficits in doubly transgenic mice correlate with amyloid burden Neurobiology of Aging. 21: 18. DOI: 10.1016/S0197-4580(00)82758-X  0.608
1999 Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behavior Genetics. 29: 177-85. PMID 10547924 DOI: 10.1023/A:1021691918517  0.649
1998 Morgan D, Holcomb L, Saad I, Gordon M, Mahin Maines. Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1 Brain Research. 808: 110-112. PMID 9795173 DOI: 10.1016/S0006-8993(98)00803-8  0.562
1998 Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine. 4: 97-100. PMID 9427614 DOI: 10.1038/Nm0198-097  0.644
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