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Meredith Irwin - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Microbiology Biology, Bioinformatics Biology
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Niazi MK, Chung JH, Heaton-Johnson KJ, Martinez D, Castellanos R, Irwin M, Master SR, Pawel B, Gurcan MN, Weiser D. Advancing clinicopathologic diagnosis of high-risk neuroblastoma using computerized image analysis and proteomic profiling. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. PMID 27442894 DOI: 10.2350/16-04-1813-Oa.1  0.577
2014 Morgenstern DA, Soh SY, Stavropoulos DJ, Bowdin S, Baruchel S, Malkin D, Meyn MS, Irwin MS. Metachronous neuroblastoma in an infant with germline translocation resulting in partial trisomy 2p: a role for ALK? Journal of Pediatric Hematology/Oncology. 36: e193-6. PMID 24276038 DOI: 10.1097/Mph.0B013E3182A8F25D  0.331
2013 Gonzalez-Cano L, Hillje AL, Fuertes-Alvarez S, Marques MM, Blanch A, Ian RW, Irwin MS, Schwamborn JC, Marín MC. Regulatory feedback loop between TP73 and TRIM32. Cell Death & Disease. 4: e704. PMID 23828567 DOI: 10.1038/cddis.2013.224  0.396
2013 Blanch A, Robinson F, Watson IR, Cheng LS, Irwin MS. Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. Plos One. 8: e66436. PMID 23799104 DOI: 10.1371/journal.pone.0066436  0.433
2012 Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M. Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Proceedings of the National Academy of Sciences of the United States of America. 109: 4892-7. PMID 22411794 DOI: 10.1073/Pnas.1112129109  0.591
2011 Chung J, Grant RI, Kaplan DR, Irwin MS. Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. The Journal of Biological Chemistry. 286: 40671-80. PMID 21965674 DOI: 10.1074/jbc.M111.271189  0.622
2010 Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. Embo Reports. 11: 777-83. PMID 20829881 DOI: 10.1038/Embor.2010.125  0.621
2010 Chung J, Irwin MS. Targeting the p53-family in cancer and chemosensitivity: triple threat. Current Drug Targets. 11: 667-81. PMID 20298155  0.633
2010 Wolter J, Angelini P, Irwin M. p53 family: Therapeutic targets in neuroblastoma. Future Oncology (London, England). 6: 429-44. PMID 20222799 DOI: 10.2217/fon.09.176  0.431
2009 Roberts AM, Watson IR, Evans AJ, Foster DA, Irwin MS, Ohh M. Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Research. 69: 9056-64. PMID 19920202 DOI: 10.1158/0008-5472.Can-09-1770  0.407
2009 Watson IR, Li BK, Roche O, Blanch A, Ohh M, Irwin MS. Chemotherapy induces NEDP1-mediated destabilization of MDM2. Oncogene. 29: 297-304. PMID 19784069 DOI: 10.1038/onc.2009.314  0.376
2009 Lau LM, Wolter JK, Lau JT, Cheng LS, Smith KM, Hansford LM, Zhang L, Baruchel S, Robinson F, Irwin MS. Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. Oncogene. 28: 2024-33. PMID 19363520 DOI: 10.1038/onc.2009.59  0.393
2008 Lau LM, Nugent JK, Zhao X, Irwin MS. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene. 27: 997-1003. PMID 17700533 DOI: 10.1038/sj.onc.1210707  0.404
2007 Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS. Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Oncogene. 26: 1920-31. PMID 16983334 DOI: 10.1038/sj.onc.1209981  0.367
2006 Watson IR, Blanch A, Lin DC, Ohh M, Irwin MS. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. The Journal of Biological Chemistry. 281: 34096-103. PMID 16980297 DOI: 10.1074/jbc.M603654200  0.366
2006 Watson IR, Irwin MS. Ubiquitin and ubiquitin-like modifications of the p53 family. Neoplasia (New York, N.Y.). 8: 655-66. PMID 16925948 DOI: 10.1593/neo.06439  0.36
2005 Stickle NH, Cheng LS, Watson IR, Alon N, Malkin D, Irwin MS, Ohh M. Expression of p53 in renal carcinoma cells is independent of pVHL. Mutation Research. 578: 23-32. PMID 15998523 DOI: 10.1016/J.Mrfmmm.2005.02.016  0.401
2004 Irwin MS. Family feud in chemosensitvity: p73 and mutant p53. Cell Cycle (Georgetown, Tex.). 3: 319-23. PMID 14739781  0.336
2003 Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG. Chemosensitivity linked to p73 function Cancer Cell. 3: 403-410. PMID 12726865 DOI: 10.1016/S1535-6108(03)00078-3  0.403
2002 Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin WG, Liu W. The human p73 promoter: characterization and identification of functional E2F binding sites. Neoplasia (New York, N.Y.). 4: 195-203. PMID 11988839 DOI: 10.1038/Sj.Neo.7900237  0.324
2001 Irwin MS, Kaelin WG. Role of the newer p53 family proteins in malignancy. Apoptosis : An International Journal On Programmed Cell Death. 6: 17-29. PMID 11321038 DOI: 10.1023/A:1009663809458  0.416
2000 Zaika A, Irwin M, Sansome C, Moll UM. Oncogenes induce and activate endogenous p73 protein. The Journal of Biological Chemistry. 276: 11310-6. PMID 11115495 DOI: 10.1074/JBC.M005737200  0.415
2000 Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 407: 645-8. PMID 11034215 DOI: 10.1038/35036614  0.384
2000 Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature. 407: 642-5. PMID 11034214 DOI: 10.1038/35036608  0.332
2000 Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, James N, McGregor JM, Harwood CA, Yulug IG, Vousden KH, Allday MJ, Gusterson B, Ikawa S, Hinds PW, et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour Nature Genetics. 25: 47-54. PMID 10802655 DOI: 10.1038/75586  0.381
1998 Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D, Kaelin WG. Viral oncoproteins discriminate between p53 and the p53 homolog p73 Molecular and Cellular Biology. 18: 6316-6324. PMID 9774648 DOI: 10.1128/Mcb.18.11.6316  0.382
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