Wayne Bowen, Ph.D. - Related publications

Molecular Pharmacology, Physiology & Biotechnology Brown University, Providence, RI 
Sigma receptors, pharmacology
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Møllerud S, Hansen RB, Pallesen J, Temperini P, Pasini D, Bornholt J, Nielsen B, Mamedova E, Chalupnik P, Paternain AV, Lerma J, Diaz-delCastillo M, Andreasen JT, Frydenvang K, Kastrup JS, et al. -(7-(1-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology. Acs Chemical Neuroscience. PMID 31622082 DOI: 10.1021/acschemneuro.9b00479   
2019 Dopart R, Kendall DA. Allosteric modulators restore orthosteric agonist binding to mutated CB receptors. The Journal of Pharmacy and Pharmacology. PMID 31722122 DOI: 10.1111/jphp.13193   
2019 Qing R, Han Q, Skuhersky M, Chung H, Badr M, Schubert T, Zhang S. QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31776256 DOI: 10.1073/pnas.1909026116   
2019 Matos MJ, Vilar S, Vazquez-Rodriguez S, Kachler S, Klotz KN, Buccioni M, Delogu G, Santana L, Uriarte E, Borges F. Structure-based optimization of coumarin hA3 adenosine receptor antagonists. Journal of Medicinal Chemistry. PMID 31738058 DOI: 10.1021/acs.jmedchem.9b01572   
2019 Hu X, Provasi D, Ramsey S, Filizola M. Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation. Biophysical Journal. PMID 31676132 DOI: 10.1016/j.bpj.2019.10.007   
2019 Wood M, Daniels V, Provins L, Wolff C, Kaminski RM, Gillard M. Pharmacological profile of the novel antiepileptic drug candidate padsevonil - interactions with synaptic vesicle 2 proteins and the GABAA receptor. The Journal of Pharmacology and Experimental Therapeutics. PMID 31619465 DOI: 10.1124/jpet.119.261149   
2019 Soave M, Kellam B, Woolard J, Briddon SJ, Hill SJ. NanoBiT Complementation to Monitor Agonist-Induced Adenosine A Receptor Internalization. Slas Discovery : Advancing Life Sciences R & D. 2472555219880475. PMID 31583945 DOI: 10.1177/2472555219880475   
2019 Gado F, Arena C, Fauci C, Reynoso-Moreno I, Bertini S, Digiacomo M, Meini S, Poli G, Macchia M, Tuccinardi T, Gertsch J, Chicca A, Manera C. Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system. Bioorganic Chemistry. 103353. PMID 31668465 DOI: 10.1016/j.bioorg.2019.103353   
2019 Piotrowska A, Siwek A, Wolak M, Nowak G. Analysis of Density Changes of Selected Brain Receptors After a 14-Day Supply of Chromium(III) and Evaluation of Chromium(III) Affinity to Selected Receptors and Transporters. Biological Trace Element Research. PMID 31732929 DOI: 10.1007/s12011-019-01924-y   
2019 Niso M, Mosier PD, Marottoli R, Ferorelli S, Cassano G, Gasparre G, Leopoldo M, Berardi F, Abate C. High-affinity sigma-1 (σ) receptor ligands based on the σ antagonist PB212. Future Medicinal Chemistry. 11: 2547-2562. PMID 31633399 DOI: 10.4155/fmc-2019-0042   
2019 Qu L, Zhou Q, Xu Y, Guo Y, Chen X, Yao D, Han GW, Liu ZJ, Stevens RC, Zhong G, Wu D, Zhao S. Structural Basis of the Diversity of Adrenergic Receptors. Cell Reports. 29: 2929-2935.e4. PMID 31801060 DOI: 10.1016/j.celrep.2019.10.088   
2019 Cooper SL, March J, Sabbatini AR, Hill SJ, Jörg M, Scammells PJ, Woolard J. The effect of two selective A -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats. British Journal of Pharmacology. PMID 31596949 DOI: 10.1111/bph.14870   
2019 Li G, Li W, Xie Y, Wan X, Zheng G, Huang N, Zhou Y. Discovery of Novel Pim-1 Kinase Inhibitors with a Flexible-Receptor Docking Protocol. Journal of Chemical Information and Modeling. PMID 31609618 DOI: 10.1021/acs.jcim.9b00494   
2019 Mortensen M, Krall J, Kongstad KT, Brygger BM, Lenzi O, Francotte P, Sørensen TE, Nielsen B, Jensen AA, Smart TG, Frølund B. Developing new 4-PIOL and 4-PHP analogues for photo-inactivation of γ-aminobutyric acid type A receptors. Acs Chemical Neuroscience. PMID 31589403 DOI: 10.1021/acschemneuro.9b00478   
2019 Ahmed H, Haider A, Varisco J, Stanković M, Wallimann R, Gruber S, Iten I, Häne S, Müller Herde A, Keller C, Schibli R, Schepmann D, Mu L, Wünsch B, Ametamey SM. Structure-Affinity Relationships of 2,3,4,5-Tetrahydro-1-3-benzazepine and 6,7,8,9-Tetrahydro-5-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1-3-benzazepine Congener for Imaging GluN2B Subunit-Containing -Methyl-d-aspartate Receptors. Journal of Medicinal Chemistry. PMID 31657559 DOI: 10.1021/acs.jmedchem.9b00812   
2019 Zhou Y, Cao C, He L, Wang X, Zhang XC. Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. Elife. 8. PMID 31750832 DOI: 10.7554/eLife.48822   
2019 An S, Yu J, Choi H, Ko H, Ahn S, Shin JC, Pyo JJ, Jeong LS, Noh M. Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. Bioorganic & Medicinal Chemistry. 115226. PMID 31806266 DOI: 10.1016/j.bmc.2019.115226   
2019 Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K. Differential allosteric modulation within dopamine DR - neurotensin NTS1R and DR - serotonin 5-HTR receptor complexes gives bias to intracellular calcium signalling. Scientific Reports. 9: 16312. PMID 31704949 DOI: 10.1038/s41598-019-52540-8   
2019 Katayama K, Suzuki K, Suno R, Tsujimoto H, Iwata S, Kobayashi T, Kandori H. Ligand Binding-Induced Structural Changes in the M Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy. The Journal of Physical Chemistry Letters. 10: 7270-7276. PMID 31692352 DOI: 10.1021/acs.jpclett.9b02942   
2019 Scott JS, Breed J, Carbajo RJ, Davey PR, Greenwood R, Huynh HK, Klinowska T, Morrow CJ, Moss TA, Polanski R, Nissink JWM, Varnes J, Yang B. Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry. Acs Medicinal Chemistry Letters. 10: 1492-1497. PMID 31620239 DOI: 10.1021/acsmedchemlett.9b00370   
2019 Xu WJ, Wang YY, Zhao Y, Jia H, Tang JS, Huo FQ, Liu H. Involvement of 5-HT2A, 5-HT2B and 5-HT2C receptors in mediating the ventrolateral orbital cortex-induced antiallodynia in a rat model of neuropathic pain. Neuroreport. PMID 31789691 DOI: 10.1097/WNR.0000000000001377   
2019 Trevor CE, Gonzalez-Munoz AL, Macleod OJS, Woodcock PG, Rust S, Vaughan TJ, Garman EF, Minter R, Carrington M, Higgins MK. Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nature Microbiology. PMID 31636418 DOI: 10.1038/s41564-019-0589-0   
2019 Landi A, Mari M, Kleiser S, Wolf T, Gretzmeier C, Wilhelm I, Kiritsi D, Thünauer R, Geiger R, Nyström A, Reggiori F, Claudinon J, Römer W. lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling. Life Science Alliance. 2. PMID 31732693 DOI: 10.26508/lsa.201900422   
2019 Stauch B, Johansson LC, Cherezov V. Structural Insights into Melatonin Receptors. The Febs Journal. PMID 31693784 DOI: 10.1111/febs.15128   
2019 Temme L, Börgel F, Schepmann D, Robaa D, Sippl W, Daniliuc C, Wünsch B. Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry. 115146. PMID 31648876 DOI: 10.1016/j.bmc.2019.115146   
2019 Wágner G, Mocking T, Arimont M, Provensi G, Rani B, Silva-Marques B, Latacz G, Da Costa Pereira D, Karatzidou C, Vischer HF, Wijtmans M, Kiec-Kononowicz K, De Esch IJP, Leurs R. 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as high-affinity non-imidazole histamine H3 receptor agonists with in vivo central nervous system activity. Journal of Medicinal Chemistry. PMID 31675226 DOI: 10.1021/acs.jmedchem.9b01462   
2019 Sekhar DP, Kumar L, Kesavan R, Purushottaman S, Mohammed ZU, Rajan S. Comparison of the Analgesic Efficacy of a Single Dose of Epidural Dexmedetomidine versus Fentanyl as an Adjuvant to Bupivacaine in Abdominal Surgery. Anesthesia, Essays and Researches. 13: 465-470. PMID 31602062 DOI: 10.4103/aer.AER_102_19   
2019 Porter MR, Xiao H, Wang J, Smith SB, Topczewski JJ. 3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT, 5-HT, or σ Receptor Ligands. Acs Medicinal Chemistry Letters. 10: 1436-1442. PMID 31620230 DOI: 10.1021/acsmedchemlett.9b00225   
2019 Wu X, Zhang Y, Xu Y. Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist. Journal of Medicinal Chemistry. PMID 31751137 DOI: 10.1021/acs.jmedchem.9b01753   
2019 Pillaiyar T, Funke M, Al-Hroub H, Weyler S, Ivanova S, Schlegel J, Abdelrahman A, Müller CE. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y and GPR17. European Journal of Medicinal Chemistry. 111789. PMID 31727469 DOI: 10.1016/j.ejmech.2019.111789   
2019 Qu L, Zhang X, Wang J, Zhou H, Hou T, Wei L, Xu F, Liang X. Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 31781785 DOI: 10.1007/s00210-019-01756-6   
2019 Xu Z, Zhu G, Chen P, Dai X, Yan LT. Optimal ligand-receptor binding for highly efficient capture of vesicles in nanofluidic transportation. Nanoscale. PMID 31746900 DOI: 10.1039/c9nr07337j   
2019 Rose TN, Jacobs ML, Reid DJ, Bouwmeester CJ, Conley MP, Fatehi B, Matta TM, Barr JT. Real-world impact on monthly glucose-lowering medication cost, HbA, weight, and polytherapy after initiating a GLP-1 receptor agonist. Journal of the American Pharmacists Association : Japha. PMID 31611005 DOI: 10.1016/j.japh.2019.09.001   
2019 Scharf MM, Bunemann M, Baker JG, Kolb P. Comparative docking to distinct G protein-coupled receptor conformations exclusively yields ligands with agonist efficacy. Molecular Pharmacology. PMID 31624135 DOI: 10.1124/mol.119.117515   
2019 Poleszak E, Wośko S, Sławińska K, Wyska E, Szopa A, Sobczyński J, Wróbel A, Doboszewska U, Wlaź P, Wlaź A, Szponar J, Skałecki P, Serefko A. Ligands of the CB2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice. Behavioural Brain Research. 112297. PMID 31626848 DOI: 10.1016/j.bbr.2019.112297   
2019 Darmani NA, Belkacemi L, Zhong W. Δ-THC and related cannabinoids suppress substance P- induced neurokinin NK-receptor-mediated vomiting via activation of cannabinoid CB receptor. European Journal of Pharmacology. 172806. PMID 31738934 DOI: 10.1016/j.ejphar.2019.172806   
2019 Ortiz Zacarías NV, van Veldhoven JPD, den Hollander LS, Dogan B, Openy J, Hsiao YY, Lenselink EB, Heitman LH, IJzerman AP. Synthesis and pharmacological evaluation of triazolo-pyrimidinone derivatives as noncompetitive, intracellular antagonists for CC chemokine receptors 2 and 5. Journal of Medicinal Chemistry. PMID 31742400 DOI: 10.1021/acs.jmedchem.9b00742   
2019 Haider A, Kretz J, Gobbi LC, Ahmed H, Atz K, Bürkler M, Bartelmus C, Fingerle J, Guba W, Ullmer C, Honer M, Knuesel I, Weber M, Brink A, Müller Herde A, et al. Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. Journal of Medicinal Chemistry. PMID 31751140 DOI: 10.1021/acs.jmedchem.9b01280   
2019 Kwon H, Yang Y, Kumar S, Lee DW, Bajracharya P, Calkins TL, Kim Y, Pietrantonio PV. Characterization of the first insect prostaglandin (PGE) receptor: MansePGER is expressed in oenocytoids and lipotheicoic acid (LTA) increases transcript expression. Insect Biochemistry and Molecular Biology. 103290. PMID 31790798 DOI: 10.1016/j.ibmb.2019.103290   
2019 Yang EL, Sun B, Huang ZY, Lin JG, Jiao B, Xiang L. Synthesis, Purification, and Selective β-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from . Journal of Natural Products. PMID 31625751 DOI: 10.1021/acs.jnatprod.9b00418   
2019 Pregernig A, Müller M, Held U, Beck-Schimmer B. Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis. Annals of Intensive Care. 9: 125. PMID 31705327 DOI: 10.1186/s13613-019-0600-1   
2019 Zhu F, Wang Y, Du Q, Ge W, Li Z, Wang X, Fu C, Luo L, Tian S, Ma H, Zheng J, Zhang Y, Sun X, He S, Zhang X. Structural optimization of aminopyrimidine-based CXCR4 antagonists. European Journal of Medicinal Chemistry. 111914. PMID 31806538 DOI: 10.1016/j.ejmech.2019.111914   
2019 Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, et al. A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611414 DOI: 10.1073/pnas.1908662116   
2019 Yasuda RP. Adenosine STEPs on synaptic function: An Editorial for 'The activity of the STriatal-enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A2A receptor on' doi: 10.1111/jnc.14866. Journal of Neurochemistry. PMID 31724181 DOI: 10.1111/jnc.14901   
2019 Cumming P, Marton J, Lilius TO, Olberg DE, Rominger A. A Survey of Molecular Imaging of Opioid Receptors. Molecules (Basel, Switzerland). 24. PMID 31752279 DOI: 10.3390/molecules24224190   
2019 Tan A, Babak MV, Venkatesan G, Lim C, Klotz KN, Herr DR, Cheong SL, Federico S, Spalluto G, Ong WY, Chen YZ, Loo JSE, Pastorin G. Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy. Molecules (Basel, Switzerland). 24. PMID 31614517 DOI: 10.3390/molecules24203661   
2019 Miller LA, Cossette C, Chourey S, Ye Q, Reddy CN, Rokach J, Powell WS. Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid (OXE) receptor antagonist in nonhuman primates. British Journal of Pharmacology. PMID 31655023 DOI: 10.1111/bph.14872   
2019 Pham B, Arons AB, Vincent JG, Fernandez EJ, Shen T. Regulatory Mechanics of Constitutive Androstane Receptor: Basal and Ligand-directed Actions. Journal of Chemical Information and Modeling. PMID 31714771 DOI: 10.1021/acs.jcim.9b00695   
2019 Andrud K, Xing H, Gabrielsen B, Bloom L, Mahnir V, Lee S, Green BT, Lindstrom J, Kem W. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Marine Drugs. 17. PMID 31671780 DOI: 10.3390/md17110614   
2019 Kwon J, Lee H, Ryu SM, Jang Y, Kwon HC, Guo Y, Kang JS, Kim JJ, Lee D. -Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation. Journal of Natural Products. PMID 31599157 DOI: 10.1021/acs.jnatprod.9b00559