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Patrick Harran - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Area:
total synthesis of naturally occurring molecules
Website:
http://faculty.chemistry.ucla.edu/institution/personnel?personnel_id=552980
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hurlow EE, Lin JB, Dweck MJ, Nuryyeva S, Feng Z, Allred TK, Houk KN, Harran PG. Photorearrangement of [8]-2,6-Pyridinophane -Oxide. Journal of the American Chemical Society. PMID 33226803 DOI: 10.1021/jacs.0c09310  0.636
2019 Feng Z, Allred TK, Hurlow EE, Harran PG. Anomalous Chromophore Disruption Enables an Eight-Step Synthesis and Stereochemical Reassignment of (+)-Marineosin A. Journal of the American Chemical Society. PMID 30691264 DOI: 10.1021/jacs.9b00396  0.708
2018 Ding H, Roberts AG, Chiang R, Harran PG. Cascading auto-oxidative biproline guanylations form optically active dispacamide dimers and permit an eight-step synthesis of (-)-ageliferin. The Journal of Organic Chemistry. PMID 29708748 DOI: 10.1021/Acs.Joc.8B00631  0.541
2016 Rose TE, Curtin BH, Lawson KV, Simon A, Houk KN, Harran PG. On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. Chemical Science. 7: 4158-4166. PMID 30155060 DOI: 10.1039/C5Sc04612B  0.753
2016 Rose TE, Curtin BH, Lawson KV, Simon A, Houk KN, Harran PG. On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan Chemical Science. 7: 4158-4166. DOI: 10.1039/c5sc04612b  0.752
2015 Rose TE, Lawson KV, Harran PG. Large ring-forming alkylations provide facile access to composite macrocycles. Chemical Science. 6: 2219-2223. PMID 28694951 DOI: 10.1039/C4Sc03848G  0.738
2015 Bracken JD, Carlson AD, Frederich JH, Nguyen M, Shore GC, Harran PG. Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro. Tetrahedron Letters. 56: 3612-3616. PMID 26019371 DOI: 10.1016/J.Tetlet.2015.01.191  0.736
2015 Wieczorek M, Tcherkezian J, Bernier C, Ocal O, Chabaan S, Rolland Y, Godbout C, Hancock M, Rocha C, Olieric N, Prota AE, Steinmetz MO, Wilkie TM, Brekken RA, Ding H, ... Harran P, et al. Abstract A188: Diazonamide DZ 2384, a potential therapeutic for pancreatic cancer, binds to tubulin with a unique impact on microtubule dynamics and tubulin curvature Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-A188  0.315
2015 Rose TE, Lawson KV, Harran PG. Large ring-forming alkylations provide facile access to composite macrocycles Chemical Science. 6: 2219-2223. DOI: 10.1039/c4sc03848g  0.705
2014 Bracken JD, Carlson AD, Frederich JH, Nguyen M, Shore GC, Harran PG. Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro Tetrahedron Letters. DOI: 10.1016/j.tetlet.2015.01.191  0.716
2013 Lawson KV, Rose TE, Harran PG. Template-constrained macrocyclic peptides prepared from native, unprotected precursors. Proceedings of the National Academy of Sciences of the United States of America. 110: E3753-60. PMID 24043790 DOI: 10.1073/Pnas.1311706110  0.722
2013 Lawson KV, Rose TE, Harran PG. Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan. Tetrahedron. 69: 7683-7691. PMID 23976797 DOI: 10.1016/J.Tet.2013.05.060  0.742
2013 Frederich JH, Matsui JK, Chang RO, Harran PG. Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles. Tetrahedron Letters. 54: 2645-2647. PMID 23814321 DOI: 10.1016/J.Tetlet.2013.03.034  0.763
2013 Ding H, Roberts AG, Harran PG. Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement. Chemical Science (Royal Society of Chemistry : 2010). 4: 303-306. PMID 23687567 DOI: 10.1039/C2Sc21651E  0.595
2013 Frederich JH, Harran PG. Modular access to complex prodiginines: Total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer Journal of the American Chemical Society. 135: 3788-3791. PMID 23452332 DOI: 10.1021/Ja400473V  0.766
2013 Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells Nature Chemical Biology. 9: 84-89. PMID 23292651 DOI: 10.1038/Nchembio.1153  0.312
2013 Ding H, Roberts AG, Harran PG. Total synthesis of ageliferin via acyl N-amidinyliminium ion rearrangement Chemical Science. 4: 303-306. DOI: 10.1039/c2sc21651e  0.491
2012 Ding H, Roberts AG, Harran PG. Synthetic (±)-axinellamines deficient in halogen Angewandte Chemie - International Edition. 51: 4340-4343. PMID 22431425 DOI: 10.1002/Anie.201200205  0.606
2011 Lawson KV, Rose TE, Harran PG. Synthesis of a designed sesquiterpenoid that forms useful composites with peptides and related oligomers Tetrahedron Letters. 52: 653-654. DOI: 10.1016/J.Tetlet.2010.11.083  0.717
2009 Li Q, Hurley P, Ding H, Roberts AG, Akella R, Harran PG. Exploring symmetry-based logic for a synthesis of Palau'amine Journal of Organic Chemistry. 74: 5909-5919. PMID 19603820 DOI: 10.1021/Jo900755R  0.573
2007 Wang G, Shang L, Burgett AW, Harran PG, Wang X. Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proceedings of the National Academy of Sciences of the United States of America. 104: 2068-73. PMID 17287350 DOI: 10.1073/Pnas.0610832104  0.739
2007 Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proceedings of the National Academy of Sciences of the United States of America. 104: 2074-9. PMID 17287337 DOI: 10.1073/Pnas.0611340104  0.753
2007 Minna JD, Girard L, Sato M, Peyton M, Lee W, Shames D, Honorio S, Xie Y, Xie X, Lam D, Lockwood W, Lam W, Wang Y, Lam S, Kim E, ... ... Harran P, et al. M10-01: Molecular pathogenesis of lung cancer with translation to the clinic Journal of Thoracic Oncology. 2: S178-S179. DOI: 10.1097/01.Jto.0000282957.22684.90  0.578
2006 Zubovych I, Doundoulakis T, Harran PG, Roth MG. A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance Proceedings of the National Academy of Sciences of the United States of America. 103: 15523-15528. PMID 17032754 DOI: 10.1073/pnas.0607338103  0.435
2004 Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG. A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (New York, N.Y.). 305: 1471-4. PMID 15353805 DOI: 10.1126/Science.1098231  0.599
2003 Burgett AW, Li Q, Wei Q, Harran PG. A concise and flexible total synthesis of (-)-diazonamide A. Angewandte Chemie (International Ed. in English). 42: 4961-6. PMID 14579451 DOI: 10.1002/anie.200352577  0.765
2001 Li J, Burgett AW, Esser L, Amezcua C, Harran PG. Preview. Angewandte Chemie (International Ed. in English). 40: 4776. PMID 12404413 DOI: 10.1002/1521-3773(20011217)40:24<4776::AID-ANIE4776>3.0.CO;2-U  0.702
2001 Li J, Burgett AW, Esser L, Amezcua C, Harran PG. Total Synthesis of Nominal Diazonamides-Part 2: On the True Structure and Origin of Natural Isolates Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. We are grateful to Professor Michael Roth for his time, insight, and advice. Angewandte Chemie (International Ed. in English). 40: 4770-4773. PMID 12404412 DOI: 10.1002/1521-3773(20011217)40:24<4770::Aid-Anie4770>3.0.Co;2-T  0.766
2001 Li J, Chen X, Burgett AW, Harran PG. Synthetic seco Forms of (-)-Diazonamide A We thank Prof. Michael Roth for advice and insight and Ms. Susan Jeong for invaluable experimental assistance. Funding was provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), and the Robert A. Welch Foundation. Angewandte Chemie (International Ed. in English). 40: 2682-2685. PMID 11458372 DOI: 10.1002/1521-3773(20010716)40:14<2682::AID-ANIE2682>3.0.CO;2-R  0.723
1998 Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proceedings of the National Academy of Sciences of the United States of America. 95: 6624-9. PMID 9618462 DOI: 10.1073/Pnas.95.12.6624  0.781
1998 Wender PA, Martin-Cantalejo Y, Carpenter AJ, Chiu A, De Brabander J, Harran PG, Jimenez JM, Koehler MFT, Lippa B, Morrison JA, Müller SG, Müller SN, Park CM, Shiozaki M, Siedenbiedel C, et al. The chemistry-medicine continuum: Synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads Pure and Applied Chemistry. 70: 539-546. DOI: 10.1351/Pac199870030539  0.781
1998 Wender PA, De Brabander J, Harran PG, Limenez JM, Koehler MFT, Lippa B, Park CM, Shiozaki M. Synthesis of the first members of a new class of biologically active bryostatin analogues [2] Journal of the American Chemical Society. 120: 4534-4535. DOI: 10.1021/Ja9727631  0.788
1998 Wender PA, De Brabander J, Harran PG, Hinkle KW, Lippa B, Pettit GR. Synthesis and biological evaluation of fully synthetic bryostatin analogues Tetrahedron Letters. 39: 8625-8628. DOI: 10.1016/S0040-4039(98)01955-8  0.789
1997 Harran PG, Wender PA. Alkynylation of C-H bonds via reaction with acetylenic triflones Chemtracts. 10: 522-526.  0.534
1995 Ziegler FE, Harran PG. A Synthesis of Naturally Occurring (1S,2S,3R)-4-Hydroxymethylcyclopent-4-ene-1,2,3-triol Utilizing the Cyclization of a Dioxolanyl Radical Synlett. 1995: 493-494. DOI: 10.1055/S-1995-5262  0.662
1993 Ziegler FE, Harran PG. Intramolecular addition of a dioxolanyl radical to the indole nucleus: Preparation of enantiomerically pure, oxygenated perhydro-3H-pyrrolo[1,2-a]indoles Journal of Organic Chemistry. 58: 2768-2773. DOI: 10.1021/Jo00062A019  0.7
1993 Ziegler FE, Harran PG. A route to chiral epoxypyrroloindoles via oxiranyl radical cyclization Tetrahedron Letters. 34: 4505-4508. DOI: 10.1016/0040-4039(93)88070-Y  0.68
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