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Chih-Rong Shyr, Ph.D. - Publications

Affiliations: 
2002 University of Rochester, Rochester, NY 
Area:
Molecular Biology, Cell Biology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lai KP, Yamashita S, Vitkus S, Shyr CR, Yeh S, Chang C. Corrigendum to: "Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor". Endocrinology. 161. PMID 32966551 DOI: 10.1210/endocr/bqaa148  0.769
2019 Chen J, Chou F, Yeh S, Ou Z, Shyr C, Huang C, Xiang Z, Sun Y, Messing E, Zu X, Chang C. Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling. Oncogene. PMID 31506605 DOI: 10.1038/S41388-019-0964-6  0.56
2019 Huang CP, Chen CC, Tsai YT, Wu CC, Shyr CR. Intravesical Administration of Xenogeneic Porcine Urothelial Cells Attenuates Cyclophosphamide-Induced Cystitis in Mice. Cell Transplantation. 963689718822773. PMID 30675801 DOI: 10.1177/0963689718822773  0.378
2018 Huang CP, Chen CC, Shyr CR. Xenogeneic cell therapy provides a novel potential therapeutic option for cancers by restoring tissue function, repairing cancer wound and reviving anti-tumor immune responses. Cancer Cell International. 18: 9. PMID 29371832 DOI: 10.1186/S12935-018-0501-7  0.303
2017 Huang CP, Chen CC, Shyr CR. The anti-tumor effect of intravesical administration of normal urothelial cells on bladder cancer. Cytotherapy. PMID 28818454 DOI: 10.1016/J.Jcyt.2017.06.010  0.304
2016 Chen CC, Hsieh TF, Huang CP, Yu AL, Chang WL, Shyr CR. Androgen receptor expands the population of cancer stem cells in upper urinary tract urothelial cell carcinoma cells. American Journal of Cancer Research. 6: 238-48. PMID 27186399  0.372
2015 Shang Z, Li Y, Zhang M, Tian J, Han R, Shyr CR, Messing E, Yeh S, Niu Y, Chang C. Anti-androgen therapy with Hydroxyflutamide or androgen receptor degradation enhancer ASC-J9® enhances BCG efficacy to better suppress bladder cancer progression. Molecular Cancer Therapeutics. PMID 26264279 DOI: 10.1158/1535-7163.Mct-14-1055-T  0.461
2015 Chen C, Hsieh T, Huang C, Shyr C. Androgen receptor expands the population of cancer stem cells in upper urinary tract urothelial carcinoma cells Urological Science. 26. DOI: 10.1016/J.Urols.2015.06.194  0.409
2014 Huang CP, Hsieh TF, Chen CC, Hung XF, Yu AL, Chang C, Shyr CR. Anabolic androgens affect the competitive interactions in cell migration and adhesion between normal mouse urothelial cells and urothelial carcinoma cells. Biochemical and Biophysical Research Communications. 452: 322-7. PMID 25159849 DOI: 10.1016/J.Bbrc.2014.08.039  0.512
2014 Chen L, Chang WC, Hung YC, Chang YY, Bao BY, Huang HC, Chung WM, Shyr CR, Ma WL. Androgen receptor increases CD133 expression and progenitor-like population that associate with cisplatin resistance in endometrial cancer cell line. Reproductive Sciences (Thousand Oaks, Calif.). 21: 386-94. PMID 23962788 DOI: 10.1177/1933719113497281  0.702
2013 Hsieh TF, Chen CC, Ma WL, Chuang WM, Hung XF, Tsai YR, Lin MH, Zhang Q, Zhang C, Chang C, Shyr CR. Epidermal growth factor enhances androgen receptor‑mediated bladder cancer progression and invasion via potentiation of AR transactivation. Oncology Reports. 30: 2917-22. PMID 24126741 DOI: 10.3892/Or.2013.2792  0.749
2013 Chung WM, Chang WC, Chen L, Chang YY, Shyr CR, Hung YC, Ma WL. MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. Stem Cell Research & Therapy. 4: 88. PMID 23890123 DOI: 10.1186/scrt247  0.618
2013 Chen CC, Hsieh TF, Chang CH, Ma WL, Hung XF, Tsai YR, Lin MH, Zhang C, Chang C, Shyr CR. Androgen receptor promotes the migration and invasion of upper urinary tract urothelial carcinoma cells through the upregulation of MMP-9 and COX-2. Oncology Reports. 30: 979-85. PMID 23715826 DOI: 10.3892/Or.2013.2506  0.73
2013 Hsieh TF, Chen CC, Yu AL, Ma WL, Zhang C, Shyr CR, Chang C. Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells. Oncology Letters. 5: 1325-1330. PMID 23599788 DOI: 10.3892/Ol.2013.1140  0.729
2013 Hsu JW, Hsu I, Xu D, Miyamoto H, Liang L, Wu XR, Shyr CR, Chang C. Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor. The American Journal of Pathology. 182: 1811-20. PMID 23499463 DOI: 10.1016/J.Ajpath.2013.01.018  0.62
2013 Lai KP, Lai JJ, Chang P, Altuwaijri S, Hsu JW, Chuang KH, Shyr CR, Yeh S, Chang C. Targeting thymic epithelia AR enhances T-cell reconstitution and bone marrow transplant grafting efficacy. Molecular Endocrinology (Baltimore, Md.). 27: 25-37. PMID 23250486 DOI: 10.1210/Me.2012-1244  0.734
2013 Hsieh TF, Chen CC, Chang CH, Yu AL, Ma WL, Shyr CR. The potential use of primary human upper urinary tract urothelial cell carcinoma (UUT-UCC) cultured cells for prognostic indicators and chemosensitivity test. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fã¼R Toxikologische Pathologie. 65: 703-8. PMID 23069010 DOI: 10.1016/j.etp.2012.09.003  0.671
2013 Shyr CR, Chen CC, Hsieh TF, Chang CH, Ma WL, Yeh S, Messing E, Li TH, Li FY, Chang C. The expression and actions of androgen receptor in upper urinary tract urothelial carcinoma (UUTUC) tissues and the primary cultured cells. Endocrine. 43: 191-9. PMID 22851332 DOI: 10.1007/S12020-012-9762-4  0.75
2012 Lin SJ, Ho HC, Lee YF, Liu NC, Liu S, Li G, Shyr CR, Chang C. Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reproductive Biology and Endocrinology : Rb&E. 10: 43. PMID 22676849 DOI: 10.1186/1477-7827-10-43  0.789
2012 Chen M, Yeh CR, Shyr CR, Lin HH, Da J, Yeh S. Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. Asian Journal of Andrology. 14: 546-55. PMID 22609821 DOI: 10.1038/Aja.2011.181  0.474
2012 Lai KP, Yamashita S, Vitkus S, Shyr CR, Yeh S, Chang C. Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptor. Molecular Endocrinology (Baltimore, Md.). 26: 52-66. PMID 22135068 DOI: 10.1210/Me.2011-1189  0.769
2012 Yu S, Yeh CR, Niu Y, Chang HC, Tsai YC, Moses HL, Shyr CR, Chang C, Yeh S. Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts. The Prostate. 72: 437-49. PMID 21739465 DOI: 10.1002/Pros.21445  0.606
2011 Niu Y, Wang J, Shang Z, Huang SP, Shyr CR, Yeh S, Chang C. Increased CK5/CK8-positive intermediate cells with stromal smooth muscle cell atrophy in the mice lacking prostate epithelial androgen receptor. Plos One. 6: e20202. PMID 21754978 DOI: 10.1371/Journal.Pone.0020202  0.597
2011 Tsai MY, Shyr CR, Kang HY, Chang YC, Weng PL, Wang SY, Huang KE, Chang C. The reduced trabecular bone mass of adult ARKO male mice results from the decreased osteogenic differentiation of bone marrow stroma cells. Biochemical and Biophysical Research Communications. 411: 477-82. PMID 21723262 DOI: 10.1016/J.Bbrc.2011.06.113  0.536
2011 Xie S, Ni J, Lee YF, Liu S, Li G, Shyr CR, Chang C. Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. The Journal of Biological Chemistry. 286: 21129-36. PMID 21515881 DOI: 10.1074/Jbc.M110.208181  0.756
2011 Kang HY, Shyr CR. Activins and cell migration. Vitamins and Hormones. 85: 129-48. PMID 21353879 DOI: 10.1016/B978-0-12-385961-7.00007-X  0.409
2010 Shyr CR, Tsai MY, Yeh S, Kang HY, Chang YC, Wong PL, Huang CC, Huang KE, Chang C. Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth. The Prostate. 70: 190-9. PMID 19790232 DOI: 10.1002/Pros.21052  0.571
2009 Kang HY, Huang HY, Hsieh CY, Li CF, Shyr CR, Tsai MY, Chang C, Chuang YC, Huang KE. Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1180-93. PMID 19257827 DOI: 10.1359/Jbmr.090219  0.559
2009 Shyr CR, Kang HY, Tsai MY, Liu NC, Ku PY, Huang KE, Chang C. Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology. 150: 2454-62. PMID 19131575 DOI: 10.1210/En.2008-1165  0.794
2008 Kang HY, Shyr CR, Huang CK, Tsai MY, Orimo H, Lin PC, Chang C, Huang KE. Altered TNSALP expression and phosphate regulation contribute to reduced mineralization in mice lacking androgen receptor. Molecular and Cellular Biology. 28: 7354-67. PMID 18838539 DOI: 10.1128/Mcb.00582-08  0.739
2008 Lan KC, Hseh CY, Lu SY, Chang SY, Shyr CR, Chen YT, Kang HY, Huang KE. Expression of androgen receptor co-regulators in the testes of men with azoospermia. Fertility and Sterility. 89: 1397-405. PMID 17919607 DOI: 10.1016/J.Fertnstert.2007.03.092  0.461
2006 Chang CY, Hsuuw YD, Huang FJ, Shyr CR, Chang SY, Huang CK, Kang HY, Huang KE. Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells. Fertility and Sterility. 85: 1195-203. PMID 16616092 DOI: 10.1016/J.Fertnstert.2005.11.031  0.754
2004 Collins LL, Lee YF, Heinlein CA, Liu NC, Chen YT, Shyr CR, Meshul CK, Uno H, Platt KA, Chang C. Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. Proceedings of the National Academy of Sciences of the United States of America. 101: 15058-63. PMID 15477591 DOI: 10.1073/Pnas.0405700101  0.788
2004 Mu X, Lee YF, Liu NC, Chen YT, Kim E, Shyr CR, Chang C. Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Molecular and Cellular Biology. 24: 5887-99. PMID 15199144 DOI: 10.1128/Mcb.24.13.5887-5899.2004  0.774
2003 Kim E, Xie S, Yeh SD, Lee YF, Collins LL, Hu YC, Shyr CR, Mu XM, Liu NC, Chen YT, Wang PH, Chang C. Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. The Journal of Biological Chemistry. 278: 46919-26. PMID 12954636 DOI: 10.1074/Jbc.M304088200  0.749
2003 Inui S, Lee YF, Chang E, Shyr CR, Chang C. Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. Journal of Dermatological Science. 31: 65-71. PMID 12615366 DOI: 10.1016/S0923-1811(02)00152-4  0.575
2002 Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C. Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. The Journal of Biological Chemistry. 277: 33571-9. PMID 12093804 DOI: 10.1074/Jbc.M203531200  0.737
2002 Shyr CR, Collins LL, Mu XM, Platt KA, Chang C. Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2. Molecular and Cellular Biology. 22: 4661-6. PMID 12052874 DOI: 10.1128/Mcb.22.13.4661-4666.2002  0.646
2002 Shyr CR, Hu YC, Kim E, Chang C. Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells. The Journal of Biological Chemistry. 277: 14622-8. PMID 11844790 DOI: 10.1074/Jbc.M110051200  0.745
1999 Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C. Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily. Proceedings of the National Academy of Sciences of the United States of America. 96: 14724-9. PMID 10611280 DOI: 10.1073/Pnas.96.26.14724  0.771
1999 Lee YF, Young WJ, Lin WJ, Shyr CR, Chang C. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. The Journal of Biological Chemistry. 274: 16198-205. PMID 10347174 DOI: 10.1074/Jbc.274.23.16198  0.73
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