Shirly Pinto, PhD - Publications

Affiliations: 
Merck, Semoy, Centre-Val de Loire, France 

31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Imbriglio JE, Shen DM, Liang R, Marby K, You M, Youm HW, Feng Z, London C, Xiong Y, Tata J, Verras A, Garcia-Calvo M, Song X, Addona G, McLaren DG, ... ... Pinto S, et al. The Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 (DGAT2) Inhibitors. Journal of Medicinal Chemistry. PMID 26561979 DOI: 10.1021/acs.jmedchem.5b01345  0.52
2015 Song XS, Zhang J, Chen X, Palyha O, Chung C, Sonatore LM, Wilsie L, Stout S, McLaren DG, Taggart A, Imbriglio JE, Pinto S, Garcia-Calvo M, Addona GH. Identification of DGAT2 Inhibitors Using Mass Spectrometry. Journal of Biomolecular Screening. PMID 26403520 DOI: 10.1177/1087057115607463  0.52
2014 Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. The Journal of Biological Chemistry. 289: 35770-80. PMID 25381252 DOI: 10.1074/jbc.M114.587816  0.52
2014 He S, Hong Q, Lai Z, Yang DX, Ting PC, Kuethe JT, Cernak TA, Dykstra KD, Sperbeck DM, Wu Z, Yu Y, Yang GX, Jian T, Liu J, Guiadeen D, ... ... Pinto S, et al. Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety. Acs Medicinal Chemistry Letters. 5: 1082-7. PMID 25349648 DOI: 10.1021/ml5003426  0.52
2014 Graham TH, Shu M, Verras A, Chen Q, Garcia-Calvo M, Li X, Lisnock J, Tong X, Tung EC, Wiltsie J, Hale JJ, Pinto S, Shen DM. Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 1657-60. PMID 24636945 DOI: 10.1016/j.bmcl.2014.02.070  0.52
2014 Muise ES, Zhu Y, Verras A, Karanam BV, Gorski J, Weingarth D, Lin HV, Hwa J, Thompson JR, Hu G, Liu J, He S, DeVita RJ, Shen DM, Pinto S. Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors. Plos One. 9: e88908. PMID 24558447 DOI: 10.1371/journal.pone.0088908  0.52
2013 He S, Hong Q, Lai Z, Wu Z, Yu Y, Kim DW, Ting PC, Kuethe JT, Yang GX, Jian T, Liu J, Guiadeen D, Krikorian AD, Sperbeck DM, Sonatore LM, ... ... Pinto S, et al. Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety. Acs Medicinal Chemistry Letters. 4: 773-8. PMID 24900745 DOI: 10.1021/ml400168h  0.52
2013 Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Li X, ... ... Pinto S, et al. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 6228-33. PMID 24157366 DOI: 10.1016/j.bmcl.2013.09.094  0.52
2013 DeVita RJ, Pinto S. Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors. Journal of Medicinal Chemistry. 56: 9820-5. PMID 23919406 DOI: 10.1021/jm4007033  0.52
2013 Han S, Akiyama TE, Previs SF, Herath K, Roddy TP, Jensen KK, Guan HP, Murphy BA, McNamara LA, Shen X, Strapps W, Hubbard BK, Pinto S, Li C, Li J. Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice. Journal of Lipid Research. 54: 2615-22. PMID 23828778 DOI: 10.1194/jlr.M035592  0.52
2013 Liu J, Gorski JN, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh DJ, McLaren DG, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, ... ... Pinto S, et al. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action. Obesity (Silver Spring, Md.). 21: 1406-15. PMID 23671037 DOI: 10.1002/oby.20193  0.52
2013 Lin HV, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, Kan Y, Levorse JM, Kowalik EJ, Szeto DM, Yao X, Xiao J, Chen S, Liu J, Garcia-Calvo M, ... ... Pinto S, et al. Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release. Plos One. 8: e54480. PMID 23336002 DOI: 10.1371/journal.pone.0054480  0.52
2012 Graham TH, Liu W, Verras A, Reibarkh M, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, ... ... Pinto S, et al. A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes. Bioorganic & Medicinal Chemistry Letters. 22: 2818-22. PMID 22444685 DOI: 10.1016/j.bmcl.2012.02.077  0.52
2012 Graham TH, Liu W, Verras A, Sebhat IK, Xiong Y, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, ... ... Pinto S, et al. A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 2811-7. PMID 22444683 DOI: 10.1016/j.bmcl.2012.02.075  0.52
2012 Wu Z, Yang C, Graham TH, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Shen Z, Chen Q, Bleasby K, Sinharoy R, ... ... Pinto S, et al. Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1727-30. PMID 22290078 DOI: 10.1016/j.bmcl.2011.12.098  0.52
2012 Shen HC, Ding FX, Jiang J, Verras A, Chabin RM, Xu S, Tong X, Chen Q, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Murphy BA, ... ... Pinto S, et al. Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1550-6. PMID 22264488 DOI: 10.1016/j.bmcl.2012.01.002  0.52
2012 Wu Z, Yang C, Xiong Y, Feng Z, Lombardo M, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, ... ... Pinto S, et al. Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine. Bioorganic & Medicinal Chemistry Letters. 22: 1774-8. PMID 22248857 DOI: 10.1016/j.bmcl.2011.12.064  0.52
2012 Graham TH, Shen HC, Liu W, Xiong Y, Verras A, Bleasby K, Bhatt UR, Chabin RM, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Lassman ME, Shen Z, ... ... Pinto S, et al. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 658-65. PMID 22079761 DOI: 10.1016/j.bmcl.2011.10.060  0.52
2011 McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, et al. The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species. Journal of Lipid Research. 52: 1150-61. PMID 21415123 DOI: 10.1194/jlr.M011049  0.52
2011 Shen HC, Ding FX, Zhou C, Xiong Y, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen D, ... ... Pinto S, et al. Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 1299-305. PMID 21315588 DOI: 10.1016/j.bmcl.2011.01.090  0.52
2010 Zhou C, Garcia-Calvo M, Pinto S, Lombardo M, Feng Z, Bender K, Pryor KD, Bhatt UR, Chabin RM, Geissler WM, Shen Z, Tong X, Zhang Z, Wong KK, Roy RS, et al. Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. Journal of Medicinal Chemistry. 53: 7251-63. PMID 20857914 DOI: 10.1021/jm101013m  0.52
2010 Zhao X, Southwick K, Cardasis HL, Du Y, Lassman ME, Xie D, El-Sherbeini M, Geissler WM, Pryor KD, Verras A, Garcia-Calvo M, Shen DM, Yates NA, Pinto S, Hendrickon RC. Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase. Proteomics. 10: 2882-6. PMID 20517885 DOI: 10.1002/pmic.201000145  0.52
2010 Stanley S, Pinto S, Segal J, Pérez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proceedings of the National Academy of Sciences of the United States of America. 107: 7024-9. PMID 20351287 DOI: 10.1073/pnas.1002790107  0.52
2008 Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, et al. Variations in DNA elucidate molecular networks that cause disease. Nature. 452: 429-35. PMID 18344982 DOI: 10.1038/nature06757  0.52
2006 Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience. 9: 381-8. PMID 16491079 DOI: 10.1038/nn1656  0.52
2004 Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (New York, N.Y.). 304: 110-5. PMID 15064421 DOI: 10.1126/science.1089459  0.52
2003 Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, ... ... Pinto S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37: 649-61. PMID 12597862 DOI: 10.1016/S0896-6273(03)00063-1  0.52
1999 Rohrbough J, Pinto S, Mihalek RM, Tully T, Broadie K. latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron. 23: 55-70. PMID 10402193 DOI: 10.1016/S0896-6273(00)80753-9  0.52
1999 Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron. 23: 45-54. PMID 10402192 DOI: 10.1016/S0896-6273(00)80752-7  0.52
1996 Tully T, Bolwig G, Christensen J, Connolly J, DelVecchio M, DeZazzo J, Dubnau J, Jones C, Pinto S, Regulski M, Svedberg B, Velinzon K. A return to genetic dissection of memory in Drosophila. Cold Spring Harbor Symposia On Quantitative Biology. 61: 207-18. PMID 9246449  0.52
1996 Tully T, Bolwig G, Christensen J, Connolly J, DeZazzo J, Dubnau J, Jones C, Pinto S, Regulski M, Svedberg F, Velinzon K. Genetic dissection of memory in Drosophila. Journal of Physiology, Paris. 90: 383. PMID 9089518 DOI: 10.1016/S0928-4257(97)87924-7  0.52
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