Richard Bazinet - Publications

Affiliations: 
Nutritional Sciences University of Toronto, Toronto, ON, Canada 
Area:
Nutrition, Neuroscience Biology

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Metherel AH, Klievik BJ, Cisbani G, Smith ME, Cumberford G, Bazinet RP. Blood and tissue docosahexaenoic acid (DHA, 22:6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 1869: 159422. PMID 37977491 DOI: 10.1016/j.bbalip.2023.159422  0.334
2023 Chen DK, Metherel AH, Rezaei K, Parzanini C, Chen CT, Ramsden CE, Horowitz M, Faurot KR, MacIntosh B, Zamora D, Bazinet RP. Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans. Journal of Lipid Research. 100424. PMID 37572791 DOI: 10.1016/j.jlr.2023.100424  0.388
2023 Valenzuela R, Metherel AH, Cisbani G, Smith ME, Chouinard-Watkins R, Klievik BJ, Videla LA, Bazinet RP. Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency. Biofactors (Oxford, England). PMID 37470206 DOI: 10.1002/biof.1992  0.412
2023 Martinsen A, Saleh RNM, Chouinard-Watkins R, Bazinet R, Harden G, Dick J, Tejera N, Pontifex MG, Vauzour D, Minihane AM. The Influence of Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice. Nutrients. 15. PMID 37432149 DOI: 10.3390/nu15092032  0.508
2023 Klievik BJ, Tyrrell AD, Chen CT, Bazinet RP. Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption. Pharmacology & Therapeutics. 248: 108437. PMID 37201738 DOI: 10.1016/j.pharmthera.2023.108437  0.505
2023 Shaikh SR, Bazinet RP. Heterogeneity in the response to n-3 polyunsaturated fatty acids. Current Opinion in Clinical Nutrition and Metabolic Care. 26: 284-287. PMID 36943155 DOI: 10.1097/MCO.0000000000000930  0.379
2022 Lacombe RJS, Smith ME, Perlman K, Turecki G, Mechawar N, Bazinet RP. Quantitative and Carbon Isotope Ratio Analysis of Fatty Acids Isolated from Human Brain Hemispheres. Journal of Neurochemistry. PMID 36196762 DOI: 10.1111/jnc.15702  0.562
2022 Liu J, Sahin C, Ahmad S, Magomedova L, Zhang M, Jia Z, Metherel AH, Orellana A, Poda G, Bazinet RP, Attisano L, Cummins CL, Peng H, Krause HM. The omega-3 hydroxy fatty acid 7()-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology. Science Signaling. 15: eabo1857. PMID 35857636 DOI: 10.1126/scisignal.abo1857  0.339
2022 Di Miceli M, Martinat M, Rossitto M, Aubert A, Alashmali S, Bosch-Bouju C, Fioramonti X, Joffre C, Bazinet RP, Layé S. Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice. International Journal of Molecular Sciences. 23. PMID 35743093 DOI: 10.3390/ijms23126650  0.397
2022 Hopperton KE, Pitino MA, Walton K, Kiss A, Unger SL, O'Connor DL, Bazinet RP. Docosahexaenoic acid and arachidonic acid levels are correlated in human milk: Implications for new European infant formula regulations. Lipids. PMID 35170053 DOI: 10.1002/lipd.12338  0.339
2022 Sylvestre DA, Otoki Y, Metherel AH, Bazinet RP, Slupsky CM, Taha AY. Effects of hypercapnia / ischemia and dissection on the rat brain metabolome. Neurochemistry International. 105294. PMID 35104537 DOI: 10.1016/j.neuint.2022.105294  0.363
2022 Cisbani G, Koppel A, Metherel AH, Smith ME, Aji KN, Andreazza AC, Mizrahi R, Bazinet RP. Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long-term cannabis users: A secondary analysis of a case-control study. Lipids. PMID 35075659 DOI: 10.1002/lipd.12336  0.353
2021 Furber KL, Lacombe RJS, Caine S, Thangaraj MP, Read S, Rosendahl SM, Bazinet RP, Popescu BF, Nazarali AJ. Biochemical Alterations in White Matter Tracts of the Aging Mouse Brain Revealed by FTIR Spectroscopy Imaging. Neurochemical Research. PMID 34820737 DOI: 10.1007/s11064-021-03491-y  0.313
2021 Smith ME, Cisbani G, Metherel AH, Bazinet RP. The Majority of Brain Palmitic Acid is Maintained by Lipogenesis from Dietary Sugars and is Augmented in Mice fed Low Palmitic Acid Levels from Birth. Journal of Neurochemistry. PMID 34780089 DOI: 10.1111/jnc.15539  0.442
2021 Cisbani G, Metherel AH, Smith ME, Bazinet RP. Murine and human microglial cells are relatively enriched with eicosapentaenoic acid compared to the whole brain. Neurochemistry International. 150: 105154. PMID 34384851 DOI: 10.1016/j.neuint.2021.105154  0.539
2021 Chouinard-Watkins R, Calleja M, Bazinet RP, Josse AR. Dairy product consumption is associated with a lowering of linoleic acid within serum triglycerides in adolescent females with overweight or obesity: a secondary analysis. The British Journal of Nutrition. 1-30. PMID 34027846 DOI: 10.1017/S0007114521001677  0.383
2021 Metherel AH, Rezaei K, Lacombe RJS, Bazinet RP. Plasma unesterified eicosapentaenoic acid is converted to docosahexaenoic acid (DHA) in the liver and supplies the brain with DHA in the presence or absence of dietary DHA. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 1866: 158942. PMID 33845223 DOI: 10.1016/j.bbalip.2021.158942  0.5
2021 Simopoulos AP, Serhan CN, Bazinet RP. The need for precision nutrition, genetic variation and resolution in Covid-19 patients. Molecular Aspects of Medicine. 77: 100943. PMID 33551236 DOI: 10.1016/j.mam.2021.100943  0.427
2020 McCusker MR, Bazinet RP, Metherel AH, Klein RY, Kundra A, Haibe-Kains B, Li M. Nonesterified Fatty Acids and Depression in Cancer Patients and Caregivers. Current Developments in Nutrition. 4: nzaa156. PMID 33447694 DOI: 10.1093/cdn/nzaa156  0.33
2020 Pal A, Metherel AH, Fiabane L, Buddenbaum N, Bazinet RP, Shaikh SR. Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other? Nutrients. 12. PMID 33276463 DOI: 10.3390/nu12123718  0.474
2020 Cisbani G, Bazinet RP. The role of peripheral fatty acids as biomarkers for Alzheimer's disease and brain inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 164: 102205. PMID 33271431 DOI: 10.1016/j.plefa.2020.102205  0.401
2020 Lin L, Metherel AH, Di Miceli M, Liu Z, Sahin C, Fioramonti X, Cummins CL, Layé S, Bazinet RP. Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output. Journal of Lipid Research. PMID 32826272 DOI: 10.1194/Jlr.Ra120001024  0.531
2020 Chamorro R, Gonzalez MF, Aliaga R, Gengler V, Balladares C, Barrera C, Bascuñan KA, Bazinet RP, Valenzuela R. Diet, Plasma, Erythrocytes, and Spermatozoa Fatty Acid Composition Changes in Young Vegan Men. Lipids. PMID 32757304 DOI: 10.1002/lipd.12265  0.356
2020 Gabrielson DK, Brezden-Masley C, Keith M, Bazinet RP, Sykes J, Darling PB. Evaluation of Nutritional, Inflammatory, and Fatty Acid Status in Patients with Gastric and Colorectal Cancer Receiving Chemotherapy. Nutrition and Cancer. 1-13. PMID 32340493 DOI: 10.1080/01635581.2020.1756351  0.346
2020 Ho M, Anderson GH, Lin L, Bazinet RP, Kubant R. Ethanolamides of essential α-linolenic and linoleic fatty acids suppress short-term food intake in rats. Food & Function. PMID 32191234 DOI: 10.1039/c9fo02884f  0.499
2020 Cisbani G, Koppel A, Knezevic D, Suridjan I, Mizrahi R, Bazinet RP. Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: an exploratory study. Brain, Behavior, and Immunity. PMID 32135194 DOI: 10.1016/j.bbi.2020.02.014  0.303
2020 Best LM, Williams B, Le Foll B, Mansouri E, Bazinet RP, Lin L, De Luca V, Lagzdins D, Rusjan P, Tyndale RF, Wilson AA, Hendershot CS, Heilig M, Houle S, Tong J, et al. Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31910433 DOI: 10.1038/S41386-020-0606-2  0.461
2020 Gaudette E, Watling S, Warsh J, McCluskey T, Tong J, Houle S, Rusjan PM, Rhind SG, Bazinet R, Tyndale RF, Richardson JD, Hill MN, Jelty R, Kish S, Boileau I. Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Results From a Neuroimaging Study With the Novel Fatty Acid Amide Hydrolase Probe, [C-11] Curb Biological Psychiatry. 87: S282-S283. DOI: 10.1016/J.Biopsych.2020.02.729  0.425
2019 Metherel AH, Lacombe RJS, Chouinard-Watkins R, Bazinet RP. Erratum: Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat. Journal of Lipid Research. 60: 2102. PMID 31792023 DOI: 10.1194/jlr.ERR119000440  0.353
2019 Metherel AH, Harris WS, Ge L, Gibson RA, Chouinard-Watkins R, Bazinet RP, Liu L, Brenna JT, Aristizabal-Henao JJ, Stark KD, Block RC. Interlaboratory Assessment of Dried Blood Spot Fatty Acid Compositions. Lipids. PMID 31782523 DOI: 10.1002/Lipd.12203  0.451
2019 Alashmali SM, Lin L, Trépanier MO, Cisbani G, Bazinet RP. The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus. Journal of Neuroinflammation. 16: 237. PMID 31775778 DOI: 10.1186/s12974-019-1615-0  0.591
2019 Lacombe RJS, Lee CC, Bazinet R. Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis. Journal of Lipid Research. PMID 31712249 DOI: 10.1194/jlr.D119000518  0.463
2019 Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. Lipids. PMID 31691988 DOI: 10.1002/Lipd.12197  0.467
2019 Metherel AH, Bazinet RP. Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion. Progress in Lipid Research. 101008. PMID 31626820 DOI: 10.1016/j.plipres.2019.101008  0.433
2019 Santaren ID, Bazinet RP, Liu Z, Johnston LW, Sievenpiper JL, Giacca A, Retnakaran R, Harris SB, Zinman B, Hanley AJ. The Distribution of Fatty Acid Biomarkers of Dairy Intake across Serum Lipid Fractions: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort. Lipids. PMID 31429083 DOI: 10.1002/Lipd.12185  0.3
2019 Bazinet RP, Metherel AH, Chen CT, Raza Shaikh S, Nadjar A, Joffre C, Layé S. Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression. Brain, Behavior, and Immunity. PMID 31278982 DOI: 10.1016/J.Bbi.2019.07.001  0.431
2019 Yang B, Lin L, Bazinet RP, Chien YC, Chang JP, Satyanarayanan SK, Su H, Su KP. Clinical Efficacy and Biological Regulations of ω-3 PUFA-Derived Endocannabinoids in Major Depressive Disorder. Psychotherapy and Psychosomatics. 1-10. PMID 31269506 DOI: 10.1159/000501158  0.447
2019 Pitino MA, Alashmali SM, Hopperton KE, Unger S, Pouliot Y, Doyen A, O'Connor DL, Bazinet RP. Oxylipin concentration, but not fatty acid composition, is altered in human donor milk pasteurized using both thermal and non-thermal techniques. The British Journal of Nutrition. 1-21. PMID 31006410 DOI: 10.1017/S0007114519000916  0.373
2019 Bazinet RP, Bernoud-Hubac N, Lagarde M. How the plasma lysophospholipid and unesterified fatty acid pools supply the brain with docosahexaenoic acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 142: 1-3. PMID 30773208 DOI: 10.1016/j.plefa.2018.12.003  0.509
2019 Chouinard-Watkins R, Lacombe RJS, Metherel AH, Masoodi M, Bazinet RP. DHA Esterified to Phosphatidylserine or Phosphatidylcholine is More Efficient at Targeting the Brain than DHA Esterified to Triacylglycerol. Molecular Nutrition & Food Research. e1801224. PMID 30768751 DOI: 10.1002/mnfr.201801224  0.535
2019 Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP. DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats. The Journal of Nutrition. PMID 30715388 DOI: 10.1093/jn/nxy282  0.408
2018 Taha AY, Trepanier MO, Coibanu FA, Saxena A, Jeffrey MA, Taha NMY, Burnham WM, Bazinet RP. Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats. Frontiers in Neurology. 9: 1188. PMID 30804888 DOI: 10.3389/fneur.2018.01188  0.318
2018 Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY. Brain oxylipin concentrations following hypercapnia / ischemia: effects of brain dissection and dissection time. Journal of Lipid Research. PMID 30463986 DOI: 10.1194/Jlr.D084228  0.343
2018 Chouinard-Watkins R, Bazinet RP. ACSL6 is critical for maintaining brain DHA levels. Proceedings of the National Academy of Sciences of the United States of America. PMID 30446610 DOI: 10.1073/pnas.1817557115  0.386
2018 Lin L, Metherel AH, Kitson AP, Alashmali SM, Hopperton KE, Trépanier MO, Jones PJ, Bazinet RP. Dietary fatty acids augment tissue levels of n-acylethanolamines in n-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) knockout mice. The Journal of Nutritional Biochemistry. 62: 134-142. PMID 30290332 DOI: 10.1016/j.jnutbio.2018.08.015  0.548
2018 Giuliano V, Scott Lacombe RJ, Hopperton KE, Bazinet RP. Applying stable carbon isotopic analysis at the natural abundance level to determine the origin of docosahexaenoic acid in the brain of the fat-1 mouse. Biochimica Et Biophysica Acta. PMID 30075211 DOI: 10.1016/j.bbalip.2018.07.014  0.581
2018 Lin YH, Hibbeln JR, Domenichiello AF, Ramsden CE, Salem NM, Chen CT, Jin H, Courville AB, Majchrzak-Hong SF, Rapoport SI, Bazinet RP, Miller BV. Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State. Lipids. PMID 30074625 DOI: 10.1002/Lipd.12055  0.369
2018 Johnston LW, Liu Z, Retnakaran R, Zinman B, Giacca A, Harris SB, Bazinet RP, Hanley AJ. Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes. Journal of Lipid Research. PMID 29986954 DOI: 10.1194/Jlr.P084970  0.309
2018 Lacombe RJS, Giuliano V, Chouinard-Watkins R, Bazinet RP. Natural Abundance Carbon Isotopic Analysis Indicates the Equal Contribution of Local Synthesis and Plasma Uptake to Palmitate Levels in the Mouse Brain. Lipids. PMID 29923600 DOI: 10.1002/lipd.12046  0.467
2018 Trépanier MO, Hopperton KE, Giuliano V, Masoodi M, Bazinet RP. Increased brain docosahexaenoic acid has no effect on the resolution of neuroinflammation following intracerebroventricular lipopolysaccharide injection. Neurochemistry International. PMID 29792954 DOI: 10.1016/j.neuint.2018.05.010  0.428
2018 Trépanier MO, Hildebrand KD, Nyamoya SD, Amor S, Bazinet RP, Kipp M. Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and post-mortem of multiple sclerosis brain tissue. Journal of Neurochemistry. PMID 29574981 DOI: 10.1111/jnc.14335  0.464
2018 Lacombe RJS, Chouinard-Watkins R, Bazinet RP. Brain docosahexaenoic acid uptake and metabolism. Molecular Aspects of Medicine. PMID 29305120 DOI: 10.1016/j.mam.2017.12.004  0.526
2018 Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology. Pharmacological Reviews. 70: 12-38. PMID 29217656 DOI: 10.1124/pr.117.014092  0.563
2018 Gabrielson D, Bazinet R, Brezden-Masley C, Keith M, Darling P. Nutritional, Inflammatory, and Fatty Acid Status in Gastrointestinal Cancer Journal of the Academy of Nutrition and Dietetics. 118. DOI: 10.1016/J.Jand.2018.06.274  0.439
2018 Best LM, Hendershot CS, Samantha J, Tong J, Le Foll B, Houle S, Tyndale RF, Bazinet R, Kish S, Boileau I. S265. Endocannabinoid Metabolism and Alcohol Consumption in Youth: A PET Study With the Fatty Acid Amide Hydrolase Radioligand [11C]CURB Biological Psychiatry. 83: S451. DOI: 10.1016/J.Biopsych.2018.02.1157  0.361
2018 Boileau I, Westwood D, Richardson D, Rhind S, Tyndale RF, Lanius R, Bazinet R, Lobaugh NJ, Houle S. 51. Investigating Endocannabinoid Mechanisms in Posttraumatic Stress Disorder: Neuroimaging Studies With the Novel Fatty Acid Amide Hydrolase Probe, [11C]CURB Biological Psychiatry. 83: S21. DOI: 10.1016/J.Biopsych.2018.02.068  0.432
2017 Metherel AH, Lacombe RJS, Chouinard-Watkins RE, Hopperton KE, Bazinet RP. Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model. Journal of Lipid Research. PMID 29229739 DOI: 10.1194/jlr.M081380  0.359
2017 Chouinard-Watkins R, Lacombe RJS, Bazinet RP. Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence? Current Opinion in Clinical Nutrition and Metabolic Care. PMID 29206690 DOI: 10.1097/MCO.0000000000000440  0.537
2017 Hopperton KE, James NCE, Mohammad D, Irfan M, Bazinet RP. Dietary fish oil, and to a lesser extent the fat-1 transgene, increases astrocyte activation in response to intracerebroventricular amyloid-β 1-40 in mice. Nutritional Neuroscience. 1-7. PMID 29113539 DOI: 10.1080/1028415X.2017.1396068  0.447
2017 Hopperton KE, Trépanier MO, James NCE, Chouinard-Watkins R, Bazinet RP. Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's disease. Brain, Behavior, and Immunity. PMID 29109025 DOI: 10.1016/j.bbi.2017.11.002  0.478
2017 Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP. Docosahexaenoic acid (DHA) accretion in the placenta but not the fetus is matched by plasma unesterified DHA uptake rates in pregnant Long Evans rats. Placenta. 58: 90-97. PMID 28962703 DOI: 10.1016/j.placenta.2017.08.072  0.398
2017 Alashmali SM, Kitson AP, Lin L, Lacombe RJS, Bazinet RP. Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus. Nutritional Neuroscience. 1-12. PMID 28903622 DOI: 10.1080/1028415X.2017.1372160  0.568
2017 Chouinard-Watkins R, Chen CT, Metherel AH, Lacombe RJS, Thies F, Masoodi M, Bazinet RP. Phospholipid class-specific brain enrichment in response to lysophosphatidylcholine docosahexaenoic acid infusion. Biochimica Et Biophysica Acta. 1862: 1092-1098. PMID 28760485 DOI: 10.1016/j.bbalip.2017.07.013  0.471
2017 Lacombe RJS, Giuliano V, Colombo SM, Arts MT, Bazinet RP. Compound specific isotope analysis resolves the dietary origin of docosahexaenoic acid (DHA) in the mouse brain. Journal of Lipid Research. PMID 28694298 DOI: 10.1194/jlr.D077990  0.501
2017 Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KSS, Hammock BD, Zhang L, Bazinet RP, Taha AY. Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Scientific Reports. 7: 4342. PMID 28659576 DOI: 10.1038/S41598-017-02914-7  0.451
2017 Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP. Maternal liver docosahexaenoic acid (DHA) stores are increased via higher serum unesterified DHA uptake in pregnant long Evans rats. The Journal of Nutritional Biochemistry. 46: 143-150. PMID 28628798 DOI: 10.1016/j.jnutbio.2017.05.011  0.429
2017 Islam R, Trépanier MO, Milenkovic M, Horsfall W, Salahpour A, Bazinet RP, Ramsey AJ. Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction. Npj Schizophrenia. 3: 12. PMID 28560258 DOI: 10.1038/s41537-017-0014-8  0.43
2017 Lin L, Metherel AH, Jones PJ, Bazinet RP. Fatty acid amide hydrolase (FAAH) regulates hypercapnia/ischemia-induced increases in n-acylethanolamines in mouse brain. Journal of Neurochemistry. PMID 28488728 DOI: 10.1111/jnc.14067  0.548
2017 Best L, Tong J, Le Foll B, Bazinet R, Tyndale RF, Mizrahi R, Lobaugh NJ, Houle S, Kish S, Boileau I. 619. Brain Levels of Fatty Acid Amide Hydrolase Are Not Altered in Overweight Healthy Individuals: A Pilot PET Study with [11C]CURB Biological Psychiatry. 81: S250-S251. DOI: 10.1016/J.Biopsych.2017.02.489  0.534
2016 Metherel AH, Domenichiello AF, Kitson AP, Lin YH, Bazinet RP. Serum n-3 Tetracosapentaenoic Acid and Tetracosahexaenoic Acid Increase Following Higher Dietary α-Linolenic Acid but not Docosahexaenoic Acid. Lipids. PMID 28005226 DOI: 10.1007/s11745-016-4223-0  0.425
2016 Lee HJ, Rao JS, Ertley RN, Chang L, Rapoport SI, Bazinet RP. Retraction note to: Chronic fluoxetine increases cytosolic phospholipase A2 activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat. Psychopharmacology. PMID 27999922 DOI: 10.1007/S00213-016-4499-Z  0.387
2016 Domenichiello AF, Kitson AP, Metherel AH, Chen CT, Hopperton KE, Stavro PM, Bazinet RP. Whole-Body Docosahexaenoic Acid Synthesis-Secretion Rates in Rats Are Constant across a Large Range of Dietary α-Linolenic Acid Intakes. The Journal of Nutrition. PMID 27852871 DOI: 10.3945/jn.116.232074  0.531
2016 Hopperton KE, Trépanier MO, Giuliano V, Bazinet RP. Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice. Journal of Neuroinflammation. 13: 257. PMID 27688126 DOI: 10.1186/s12974-016-0721-5  0.416
2016 Metherel AH, Domenichiello AF, Kitson AP, Hopperton KE, Bazinet RP. Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat. Biochimica Et Biophysica Acta. PMID 27263420 DOI: 10.1016/j.bbalip.2016.05.014  0.342
2016 Kitson AP, Metherel AH, Chen CT, Domenichiello AF, Trépanier MO, Berger A, Bazinet RP. Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion. The Journal of Nutritional Biochemistry. 33: 91-102. PMID 27135386 DOI: 10.1016/j.jnutbio.2016.02.009  0.45
2016 Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. The Journal of Nutritional Biochemistry. 30: 167-76. PMID 27012633 DOI: 10.1016/j.jnutbio.2015.11.016  0.437
2016 Alashmali SM, Hopperton KE, Bazinet RP. Lowering dietary n-6 polyunsaturated fatty acids: interaction with brain arachidonic and docosahexaenoic acids. Current Opinion in Lipidology. 27: 54-66. PMID 26709472 DOI: 10.1097/MOL.0000000000000255  0.567
2015 Chen CT, Kitson AP, Hopperton KE, Domenichiello AF, Trépanier MO, Lin LE, Ermini L, Post M, Thies F, Bazinet RP. Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. Scientific Reports. 5: 15791. PMID 26511533 DOI: 10.1038/Srep15791  0.423
2015 Trépanier MO, Hopperton KE, Orr SK, Bazinet RP. N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update. European Journal of Pharmacology. PMID 26036964 DOI: 10.1016/J.Ejphar.2015.05.045  0.744
2015 Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research. 59: 54-66. PMID 25920364 DOI: 10.1016/j.plipres.2015.04.002  0.46
2015 Lin LE, Chen CT, Hildebrand KD, Liu Z, Hopperton KE, Bazinet RP. Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids. Journal of Lipid Research. 56: 390-402. PMID 25477531 DOI: 10.1194/jlr.M055590  0.489
2015 Chen CT, Bazinet RP. β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 92: 33-40. PMID 24986271 DOI: 10.1016/j.plefa.2014.05.007  0.483
2014 Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nature Reviews. Neuroscience. 15: 771-85. PMID 25387473 DOI: 10.1038/nrn3820  0.56
2014 Mason JK, Kharotia S, Wiggins AK, Kitson AP, Chen J, Bazinet RP, Thompson LU. 17β-estradiol increases liver and serum docosahexaenoic acid in mice fed varying levels of α-linolenic acid. Lipids. 49: 745-56. PMID 24913495 DOI: 10.1007/S11745-014-3913-8  0.389
2014 Trépanier MO, Lim J, Lai TK, Cho HJ, Domenichiello AF, Chen CT, Taha AY, Bazinet RP, Burnham WM. Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model. Epilepsy & Behavior : E&B. 33: 138-43. PMID 24662925 DOI: 10.1016/j.yebeh.2014.02.020  0.341
2014 Chen CT, Trépanier MO, Hopperton KE, Domenichiello AF, Masoodi M, Bazinet RP. Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 376-9. PMID 24326387 DOI: 10.1038/jcbfm.2013.221  0.332
2014 Bazinet RP, Chu MW. Omega-6 polyunsaturated fatty acids: is a broad cholesterol-lowering health claim appropriate? Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 186: 434-9. PMID 24218530 DOI: 10.1503/cmaj.130253  0.346
2014 Domenichiello AF, Chen CT, Trepanier MO, Stavro PM, Bazinet RP. Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. Journal of Lipid Research. 55: 62-74. PMID 24212299 DOI: 10.1194/jlr.M042275  0.452
2014 Hopperton KE, Duncan RE, Bazinet RP, Archer MC. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Experimental Cell Research. 320: 302-10. PMID 24200503 DOI: 10.1016/j.yexcr.2013.10.016  0.329
2014 Trépanier M, Taha AY, Bazinet RP, Burnham W. 1. Daily DHA injections raise seizure thresholds and blood but not brain free DHA levels in rats Clinical Neurophysiology. 125: e9. DOI: 10.1016/j.clinph.2013.09.014  0.403
2013 Taha AY, Zahid T, Epps T, Trepanier MO, Burnham WM, Bazinet RP, Zhang L. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Research. 1537: 9-17. PMID 24036166 DOI: 10.1016/j.brainres.2013.09.004  0.377
2013 Orr SK, Palumbo S, Bosetti F, Mount HT, Kang JX, Greenwood CE, Ma DW, Serhan CN, Bazinet RP. Unesterified docosahexaenoic acid is protective in neuroinflammation. Journal of Neurochemistry. 127: 378-93. PMID 23919613 DOI: 10.1111/Jnc.12392  0.771
2013 Chen CT, Domenichiello AF, Trépanier MO, Liu Z, Masoodi M, Bazinet RP. The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms. Journal of Lipid Research. 54: 2410-22. PMID 23836105 DOI: 10.1194/jlr.M038505  0.471
2013 Orr SK, Trépanier MO, Bazinet RP. n-3 Polyunsaturated fatty acids in animal models with neuroinflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 88: 97-103. PMID 22770766 DOI: 10.1016/J.Plefa.2012.05.008  0.756
2013 Trepanier MO, Taha A, Bazinet R, Burnham M. 1. The anticonvulsant effects of n-3 PUFA: Animal studies Clinical Neurophysiology. 124: e5. DOI: 10.1016/J.Clinph.2012.08.029  0.308
2012 Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Laurent G, Domenichiello AF, Bazinet RP, Dorian P. Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 5: 978-83. PMID 22923273 DOI: 10.1161/CIRCEP.112.971515  0.336
2012 Arsenault D, Julien C, Chen CT, Bazinet RP, Calon F. Dietary intake of unsaturated fatty acids modulates physiological properties of entorhinal cortex neurons in mice. Journal of Neurochemistry. 122: 427-43. PMID 22551210 DOI: 10.1111/j.1471-4159.2012.07772.x  0.404
2012 Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Van Krieken R, Laurent G, Holub BJ, Bazinet RP, Dorian P. N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 1115-1122.e4. PMID 22342864 DOI: 10.1016/j.hrthm.2012.02.013  0.348
2011 Chen CT, Liu Z, Bazinet RP. Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. Journal of Neurochemistry. 116: 363-73. PMID 21091476 DOI: 10.1111/j.1471-4159.2010.07116.x  0.48
2010 Song BJ, Elbert A, Rahman T, Orr SK, Chen CT, Febbraio M, Bazinet RP. Genetic ablation of CD36 does not alter mouse brain polyunsaturated fatty acid concentrations. Lipids. 45: 291-9. PMID 20306148 DOI: 10.1007/S11745-010-3398-Z  0.753
2010 Orr SK, Tong JY, Kang JX, Ma DW, Bazinet RP. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochemical Research. 35: 811-9. PMID 20177777 DOI: 10.1007/S11064-010-0139-X  0.726
2010 Duncan RE, Bazinet RP. Brain arachidonic acid uptake and turnover: implications for signaling and bipolar disorder. Current Opinion in Clinical Nutrition and Metabolic Care. 13: 130-8. PMID 20145439 DOI: 10.1097/MCO.0b013e328336b615  0.537
2010 Rahman T, Taha AY, Song BJ, Orr SK, Liu Z, Chen CT, Bazinet RP. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 82: 141-5. PMID 20106645 DOI: 10.1016/J.Plefa.2009.11.003  0.743
2010 Boudrault C, Bazinet RP, Kang JX, Ma DW. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochemistry International. 56: 585-9. PMID 20064570 DOI: 10.1016/j.neuint.2009.12.022  0.478
2010 Lee HJ, Bazinet RP, Rapoport SI, Bhattacharjee AK. Brain arachidonic acid cascade enzymes are upregulated in a rat model of unilateral Parkinson disease. Neurochemical Research. 35: 613-9. PMID 19997776 DOI: 10.1007/S11064-009-0106-6  0.301
2010 Bazinet RP. Aspirin, arachidonic acid and the regulation of mood. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 82: 7-8. PMID 19910174 DOI: 10.1016/j.plefa.2009.10.008  0.387
2010 Green JT, Liu Z, Bazinet RP. Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet. Journal of Lipid Research. 51: 535-43. PMID 19661256 DOI: 10.1194/jlr.M000786  0.489
2009 Bazinet RP. Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder? Biochemical Society Transactions. 37: 1104-9. PMID 19754461 DOI: 10.1042/BST0371104  0.495
2009 Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. Neurochemistry International. 55: 476-82. PMID 19442696 DOI: 10.1016/J.Neuint.2009.04.018  0.453
2009 Chen CT, Liu Z, Ouellet M, Calon F, Bazinet RP. Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 80: 157-63. PMID 19237271 DOI: 10.1016/j.plefa.2009.01.005  0.49
2008 Chen CT, Green JT, Orr SK, Bazinet RP. Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 79: 85-91. PMID 18938067 DOI: 10.1016/J.Plefa.2008.09.003  0.771
2008 Milligan LA, Bazinet RP. Evolutionary modifications of human milk composition: evidence from long-chain polyunsaturated fatty acid composition of anthropoid milks. Journal of Human Evolution. 55: 1086-95. PMID 18809203 DOI: 10.1016/J.Jhevol.2008.07.010  0.462
2008 Orr SK, Bazinet RP. The emerging role of docosahexaenoic acid in neuroinflammation. Current Opinion in Investigational Drugs (London, England : 2000). 9: 735-43. PMID 18600579  0.77
2008 Rao JS, Lee HJ, Rapoport SI, Bazinet RP. Mode of action of mood stabilizers: is the arachidonic acid cascade a common target? Molecular Psychiatry. 13: 585-96. PMID 18347600 DOI: 10.1038/mp.2008.31  0.371
2008 Green JT, Orr SK, Bazinet RP. The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids. Journal of Lipid Research. 49: 939-44. PMID 18252846 DOI: 10.1194/Jlr.R700017-Jlr200  0.732
2008 Lee HJ, Rao JS, Chang L, Rapoport SI, Bazinet RP. Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat. Journal of Lipid Research. 49: 162-8. PMID 17957090 DOI: 10.1194/Jlr.M700406-Jlr200  0.488
2008 Chen CT, Ma DW, Kim JH, Mount HT, Bazinet RP. The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations. Journal of Lipid Research. 49: 147-52. PMID 17932396 DOI: 10.1194/jlr.M700386-JLR200  0.54
2008 Milligan LA, Rapoport SI, Cranfield MR, Dittus W, Glander KE, Oftedal OT, Power ML, Whittier CA, Bazinet RP. Fatty acid composition of wild anthropoid primate milks. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 149: 74-82. PMID 17916436 DOI: 10.1016/J.Cbpb.2007.08.006  0.445
2007 Lee HJ, Rao JS, Rapoport SI, Bazinet RP. Antimanic therapies target brain arachidonic acid signaling: lessons learned about the regulation of brain fatty acid metabolism. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 77: 239-46. PMID 18042366 DOI: 10.1016/J.Plefa.2007.10.018  0.562
2007 Lee HJ, Rao JS, Chang L, Rapoport SI, Bazinet RP. Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. Psychopharmacology. 193: 467-74. PMID 17487474 DOI: 10.1007/S00213-007-0803-2  0.457
2007 Milligan LA, Bazinet RP. Is docosahexaenoic acid a red herring for the aquatic diet?--Comments by Milligan and Bazinet. The British Journal of Nutrition. 97: 1023-4; discussion 1. PMID 17408532 DOI: 10.1017/S0007114507669232  0.354
2007 Lee HJ, Rao JS, Ertley RN, Chang L, Rapoport SI, Bazinet RP. Chronic fluoxetine increases cytosolic phospholipase A(2) activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat. Psychopharmacology. 190: 103-15. PMID 17093977 DOI: 10.1007/S00213-006-0582-1  0.371
2007 Rao JS, Ertley RN, DeMar JC, Rapoport SI, Bazinet RP, Lee HJ. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Molecular Psychiatry. 12: 151-7. PMID 16983392 DOI: 10.1038/sj.mp.4001887  0.437
2007 Rao JS, Ertley RN, Lee HJ, DeMar JC, Arnold JT, Rapoport SI, Bazinet RP. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Molecular Psychiatry. 12: 36-46. PMID 16983391 DOI: 10.1038/sj.mp.4001888  0.371
2007 Bazinet RP, Bhattacharjee AK, Lee HJ. Haloperidol targets brain arachidonic acid signaling. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31: 314-5; author reply . PMID 16797815 DOI: 10.1016/j.pnpbp.2006.03.038  0.463
2007 Pillai VC, Bazinet RP, Rapoport SI, Weis MT. Identification and characterisation of substrate requirements for brain long chain fatty acyl CoA synthase (LCAFCoAS) isoforms The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A607-A  0.386
2006 DeMar JC, Lee HJ, Ma K, Chang L, Bell JM, Rapoport SI, Bazinet RP. Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. Biochimica Et Biophysica Acta. 1761: 1050-9. PMID 16920015 DOI: 10.1016/J.Bbalip.2006.06.006  0.433
2006 Lee HJ, Mayette J, Rapoport SI, Bazinet RP. Selective remodeling of cardiolipin fatty acids in the aged rat heart. Lipids in Health and Disease. 5: 2. PMID 16430781 DOI: 10.1186/1476-511X-5-2  0.38
2006 Bazinet RP, Weis MT, Rapoport SI, Rosenberger TA. Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. Psychopharmacology. 184: 122-9. PMID 16344985 DOI: 10.1007/S00213-005-0272-4  0.534
2006 Bazinet RP, Rao JS, Chang L, Rapoport SI, Lee HJ. Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder. Biological Psychiatry. 59: 401-7. PMID 16182257 DOI: 10.1016/J.Biopsych.2005.07.024  0.507
2005 Lee HJ, Ghelardoni S, Chang L, Bosetti F, Rapoport SI, Bazinet RP. Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. Neurochemical Research. 30: 677-83. PMID 16176072 DOI: 10.1007/S11064-005-2756-3  0.477
2005 Bazinet RP, Lee HJ, Felder CC, Porter AC, Rapoport SI, Rosenberger TA. Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. Neurochemical Research. 30: 597-601. PMID 16176062 DOI: 10.1007/S11064-005-2746-5  0.405
2005 Bazinet RP, Rao JS, Chang L, Rapoport SI, Lee HJ. Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. Psychopharmacology. 182: 180-5. PMID 15986187 DOI: 10.1007/S00213-005-0059-7  0.556
2005 Ghelardoni S, Bazinet RP, Rapoport SI, Bosetti F. Topiramate does not alter expression in rat brain of enzymes of arachidonic acid metabolism. Psychopharmacology. 180: 523-9. PMID 15719218 DOI: 10.1007/S00213-005-2189-3  0.386
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