Jan Lewerenz, MD - Publications

Affiliations: 
Neurology University of Ulm, Ulm, Baden-Württemberg, Germany 

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Greguletz P, Plötz M, Baade-Büttner C, Bien CG, Eisenhut K, Geis C, Handreka R, Klausewitz J, Körtvelyessy P, Kovac S, Kraft A, Lewerenz J, Malter M, Nagel M, von Podewils F, et al. Different pain phenotypes are associated with anti-Caspr2 autoantibodies. Journal of Neurology. PMID 38386048 DOI: 10.1007/s00415-024-12224-4  0.464
2023 Theis H, Bischof GN, Brüggemann N, Dargvainiene J, Drzezga A, Grüter T, Lewerenz J, Leypoldt F, Neumaier B, Wandinger KP, Ayzenberg I, van Eimeren T. In Vivo Measurement of Tau Depositions in Anti-IgLON5 Disease Using [18F]PI-2620 PET. Neurology. 101: e2325-e2330. PMID 37879939 DOI: 10.1212/WNL.0000000000207870  0.507
2023 Brauchle F, Rapp D, Senel M, Huss A, Dreyhaupt J, Klose V, Süße M, Stürner KH, Leypoldt F, Tumani H, Lewerenz J. Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases - a retrospective cross-sectional study. Frontiers in Neurology. 14: 1193015. PMID 37396770 DOI: 10.3389/fneur.2023.1193015  0.505
2022 Madlener M, Strippel C, Thaler FS, Doppler K, Wandinger KP, Lewerenz J, Ringelstein M, Roessling R, Menge T, Wickel J, Kellingshaus C, Mues S, Kraft A, Linsa A, Tauber SC, et al. Glutamic acid decarboxylase antibody-associated neurological syndromes: Clinical and antibody characteristics and therapy response. Journal of the Neurological Sciences. 445: 120540. PMID 36608627 DOI: 10.1016/j.jns.2022.120540  0.54
2022 Kaaden T, Madlener M, Angstwurm K, Bien CG, Bogarin Y, Doppler K, Finke A, Gerner ST, Reimann G, Häusler M, Handreka R, Hellwig K, Kaufmann M, Kellinghaus C, Koertvelyessy P, ... ... Lewerenz J, et al. Seizure Semiology in Antibody-Associated Autoimmune Encephalitis. Neurology(R) Neuroimmunology & Neuroinflammation. 9. PMID 36266054 DOI: 10.1212/NXI.0000000000200034  0.532
2022 Gövert F, Abrante L, Becktepe J, Balint B, Ganos C, Hofstadt-van Oy U, Krogias C, Varley J, Irani SR, Paneva S, Titulaer MJ, de Vries JM, Boon AJW, Schreurs MWJ, Joubert B, ... ... Lewerenz J, et al. Distinct movement disorders in contactin-associated-protein-like-2 antibody associated autoimmune encephalitis. Brain : a Journal of Neurology. PMID 35875984 DOI: 10.1093/brain/awac276  0.504
2022 Strippel C, Herrera-Rivero M, Wendorff M, Tietz AK, Degenhardt F, Witten A, Schroeter C, Nelke C, Golombeck KS, Madlener M, Rüber T, Ernst L, Racz A, Baumgartner T, Widman G, ... ... Lewerenz J, et al. A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies. Brain : a Journal of Neurology. PMID 35348614 DOI: 10.1093/brain/awac119  0.532
2022 Grüter T, Möllers FE, Tietz A, Dargvainiene J, Melzer N, Heidbreder A, Strippel C, Kraft A, Höftberger R, Schöberl F, Thaler FS, Wickel J, Chung HY, Seifert F, Tschernatsch M, ... ... Lewerenz J, et al. Clinical, serological and genetic predictors of response to immunotherapy in anti-IgLON5 disease. Brain : a Journal of Neurology. PMID 35259208 DOI: 10.1093/brain/awac090  0.531
2022 Endres D, Lüngen E, Hasan A, Kluge M, Fröhlich S, Lewerenz J, Bschor T, Haußleiter IS, Juckel G, Then Bergh F, Ettrich B, Kertzscher L, Oviedo-Salcedo T, Handreka R, Lauer M, et al. Clinical manifestations and immunomodulatory treatment experiences in psychiatric patients with suspected autoimmune encephalitis: a case series of 91 patients from Germany. Molecular Psychiatry. PMID 35046526 DOI: 10.1038/s41380-021-01396-4  0.534
2021 Dürr M, Nissen G, Sühs KW, Schwenkenbecher P, Geis C, Ringelstein M, Hartung HP, Friese MA, Kaufmann M, Malter MP, Madlener M, Thaler FS, Kümpfel T, Senel M, Häusler MG, ... ... Lewerenz J, et al. CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis. Neurology(R) Neuroimmunology & Neuroinflammation. 8. PMID 34697224 DOI: 10.1212/NXI.0000000000001086  0.512
2021 Thaler FS, Zimmermann L, Kammermeier S, Strippel C, Ringelstein M, Kraft A, Sühs KW, Wickel J, Geis C, Markewitz R, Urbanek C, Sommer C, Doppler K, Penner L, Lewerenz J, et al. Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis: Real-world Evidence From the GENERATE Registry. Neurology(R) Neuroimmunology & Neuroinflammation. 8. PMID 34599001 DOI: 10.1212/NXI.0000000000001088  0.465
2021 Tietz AK, Angstwurm K, Baumgartner T, Doppler K, Eisenhut K, Elisak M, Franke A, Golombeck KS, Handreka R, Kaufmann M, Kraemer M, Kraft A, Lewerenz J, Lieb W, Madlener M, et al. Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis. Neurology(R) Neuroimmunology & Neuroinflammation. 8. PMID 34584012 DOI: 10.1212/NXI.0000000000001085  0.523
2019 Blinder T, Lewerenz J. Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis-A Systematic Analysis. Frontiers in Neurology. 10: 804. PMID 31404257 DOI: 10.3389/Fneur.2019.00804  0.323
2019 Schubert J, Brämer D, Huttner HB, Gerner ST, Fuhrer H, Melzer N, Dik A, Prüss H, Ly LT, Fuchs K, Leypoldt F, Nissen G, Schirotzek I, Dohmen C, Bösel J, ... Lewerenz J, et al. Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. Neurology(R) Neuroimmunology & Neuroinflammation. 6: e514. PMID 30568992 DOI: 10.1212/Nxi.0000000000000514  0.521
2019 Tumani H, Petereit HF, Gerritzen A, Groß CC, Huss A, Isenmann S, Jesse S, Khalil M, Lewerenz J, Leypoldt F, Melzer N, Meuth SG, Otto M, Ruprecht K, Sindern E, et al. S1-Leitlinie: Lumbalpunktion und Liquordiagnostik Dgneurologie. 2: 456-480. DOI: 10.1007/s42451-019-00126-z  0.437
2018 Baumgartner A, Rauer S, Hottenrott T, Leypoldt F, Ufer F, Hegen H, Prüss H, Lewerenz J, Deisenhammer F, Stich O. Admission diagnoses of patients later diagnosed with autoimmune encephalitis. Journal of Neurology. PMID 30421340 DOI: 10.1007/S00415-018-9105-3  0.553
2018 Lewerenz J, Ates G, Methner A, Conrad M, Maher P. Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System. Frontiers in Neuroscience. 12: 214. PMID 29731704 DOI: 10.3389/Fnins.2018.00214  0.629
2018 Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, et al. Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis. Annals of Neurology. PMID 29572931 DOI: 10.1002/Ana.25216  0.554
2017 Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A. Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radical Biology & Medicine. PMID 28807815 DOI: 10.1016/J.Freeradbiomed.2017.08.007  0.608
2017 Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, et al. Absence of system xc(-) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. Journal of Neuroinflammation. 14: 9. PMID 28086920 DOI: 10.1186/S12974-016-0787-0  0.637
2017 Lewerenz J, Jarius S, Wildemann B, Wandinger KP, Leypoldt F. [Autoantibody-associated autoimmune encephalitis and cerebellitis : Clinical presentation, diagnostic work-up and treatment]. Der Nervenarzt. 87: 1293-1299. PMID 27847964 DOI: 10.1007/S00115-016-0235-5  0.549
2015 Lewerenz J, Maher P. Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence? Frontiers in Neuroscience. 9: 469. PMID 26733784 DOI: 10.3389/Fnins.2015.00469  0.363
2015 Fauser S, Uttner I, Ariño H, Scherbaum WA, Saiz A, Lewerenz J. Long latency between GAD-antibody detection and development of limbic encephalitis - a case report. Bmc Neurology. 15: 177. PMID 26420440 DOI: 10.1186/S12883-015-0435-9  0.334
2015 Massie A, Boillée S, Hewett S, Knackstedt L, Lewerenz J. Main path and byways: non-vesicular glutamate release by system xc (-) as an important modifier of glutamatergic neurotransmission. Journal of Neurochemistry. PMID 26336934 DOI: 10.1111/Jnc.13348  0.359
2015 Gahr M, Lauda F, Wigand ME, Connemann BJ, Rosenbohm A, Tumani H, Reindl M, Uzelac Z, Lewerenz J. Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor encephalitis presenting with dysphoric mania. Bmj Case Reports. 2015. PMID 25917068 DOI: 10.1136/Bcr-2014-209075  0.314
2014 Pfeiffer A, Jaeckel M, Lewerenz J, Noack R, Pouya A, Schacht T, Hoffmann C, Winter J, Schweiger S, Schäfer MK, Methner A. Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress. British Journal of Pharmacology. 171: 2147-58. PMID 24319993 DOI: 10.1111/Bph.12549  0.645
2014 Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, et al. Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. Antioxidants & Redox Signaling. 20: 2907-22. PMID 24219064 DOI: 10.1089/Ars.2013.5455  0.609
2013 Wiesner D, Merdian I, Lewerenz J, Ludolph AC, Dupuis L, Witting A. Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2. Plos One. 8: e76670. PMID 24098549 DOI: 10.1371/Journal.Pone.0076670  0.331
2013 Albrecht P, Henke N, Tien ML, Issberner A, Bouchachia I, Maher P, Lewerenz J, Methner A. Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity. Neurochemistry International. 62: 610-9. PMID 23357478 DOI: 10.1016/J.Neuint.2013.01.019  0.657
2013 Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A. The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress. Cell Death & Disease. 4: e470. PMID 23348584 DOI: 10.1038/Cddis.2012.216  0.626
2013 Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxidants & Redox Signaling. 18: 522-55. PMID 22667998 DOI: 10.1089/Ars.2011.4391  0.627
2012 Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A. Effects of dimethyl fumarate on neuroprotection and immunomodulation. Journal of Neuroinflammation. 9: 163. PMID 22769044 DOI: 10.1186/1742-2094-9-163  0.641
2012 Leypoldt F, Buchert R, Kleiter I, Marienhagen J, Gelderblom M, Magnus T, Dalmau J, Gerloff C, Lewerenz J. Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 681-6. PMID 22566598 DOI: 10.1136/Jnnp-2011-301969  0.552
2012 Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, Thundyil J, Arumugam TV, Gerloff C, Tolosa E, Maher P, Magnus T. The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 835-43. PMID 22234339 DOI: 10.1038/Jcbfm.2011.189  0.544
2012 Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P. Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression. Cell Death and Differentiation. 19: 847-58. PMID 22095285 DOI: 10.1038/Cdd.2011.165  0.643
2012 Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Hörste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, ... Lewerenz J, et al. Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential. Human Molecular Genetics. 21: 150-62. PMID 21965300 DOI: 10.1093/Hmg/Ddr450  0.612
2012 Lewerenz J, Maher P, Methner A. Regulation of xCT expression and system x (c) (-) function in neuronal cells. Amino Acids. 42: 171-9. PMID 21369940 DOI: 10.1007/S00726-011-0862-X  0.644
2012 Lewerenz J, Maher P. The Phosphoinositide 3-Kinase-Mediated Regulation of System Xc- Activity Is Dependent Upon EIF2alpha Phosphorylation and ATF4 and Regulates the Sensitivity of Neuronal Cells to Oxidative Stress Free Radical Biology and Medicine. 53. DOI: 10.1016/J.Freeradbiomed.2012.10.206  0.322
2011 Choe CU, Lewerenz J, Gerloff C, Magnus T, Donzelli S. Nitroxyl in the central nervous system. Antioxidants & Redox Signaling. 14: 1699-711. PMID 21235347 DOI: 10.1089/Ars.2010.3852  0.311
2011 Lewerenz J, Maher P. Control of redox state and redox signaling by neural antioxidant systems. Antioxidants & Redox Signaling. 14: 1449-65. PMID 20812872 DOI: 10.1089/Ars.2010.3600  0.317
2010 Lewerenz J, Dargusch R, Maher P. Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity. Journal of Neurochemistry. 113: 502-14. PMID 20132475 DOI: 10.1111/j.1471-4159.2010.06621.x  0.417
2010 Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A. Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target. Cns & Neurological Disorders Drug Targets. 9: 373-82. PMID 20053169 DOI: 10.2174/187152710791292567  0.645
2010 Toutzaris D, Lewerenz J, Albrecht P, Jensen LT, Letz J, Geerts A, Golz S, Methner A. A novel giant peroxisomal superoxide dismutase motif-containing protein. Free Radical Biology & Medicine. 48: 811-20. PMID 20045724 DOI: 10.1016/J.Freeradbiomed.2009.12.023  0.665
2009 Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. Journal of Neurochemistry. 111: 332-43. PMID 19694903 DOI: 10.1111/J.1471-4159.2009.06347.X  0.656
2009 Choe CU, Lewerenz J, Fischer G, Uliasz TF, Espey MG, Hummel FC, King SB, Schwedhelm E, Böger RH, Gerloff C, Hewett SJ, Magnus T, Donzelli S. Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity. Journal of Neurochemistry. 110: 1766-73. PMID 19619135 DOI: 10.1111/J.1471-4159.2009.06266.X  0.356
2006 Sahin M, Saxena A, Joost P, Lewerenz J, Methner A. Induction of Bcl-2 by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione. Free Radical Research. 40: 1113-23. PMID 17050165 DOI: 10.1080/10715760600838191  0.654
2006 Leypoldt F, Eichhorn P, Saager C, Münchau A, Lewerenz J. Successful immunosuppressive treatment and long-term follow-up of anti-Ri-associated paraneoplastic myelitis. Journal of Neurology, Neurosurgery, and Psychiatry. 77: 1199-200. PMID 16980662 DOI: 10.1136/Jnnp.2005.086140  0.554
2006 Lewerenz J, Klein M, Methner A. Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity. Journal of Neurochemistry. 98: 916-25. PMID 16771835 DOI: 10.1111/J.1471-4159.2006.03921.X  0.655
2006 Lewerenz J, Methner A. Mechanismen und Bedeutung der oxidativen Glutamattoxizität E-Neuroforum. 12. DOI: 10.1515/Nf-2006-0303  0.526
2006 Lewerenz J, Methner A. Mechanisms and role of oxidative glutamate toxicity | Mechanismen und Bedeutung der oxidativen Glutamattoxizität Neuroforum. 12: 222-227.  0.585
2005 Lewerenz J, Hagel C, Matschke J, Lennon V, Leypoldt F. Paraneoplastic multifocal neuropathy with anti-CRMP5- and anti-amphiphysin antibodies and myositis preceeding recurrence of a small-cell bladder carcinoma Aktuelle Neurologie. 32. DOI: 10.1055/S-2005-919627  0.493
2005 Leypoldt F, Münchau A, Lewerenz J. Ein Fall einer paraneoplastischen Myelitis mit Anti-Ri-Antikörpern: Steuerung einer dreijährigen immunsuppressiven Therapie anhand klinischer und paraklinischer Parameter Aktuelle Neurologie. 32. DOI: 10.1055/S-2005-919408  0.461
2004 Klein M, Methner A, Lewerenz J. Excitatory amino acid transporter 3 and the glutamate/cystine antiporter system Xc- cooperatively protect neuronal HT22 cells from oxidative glutamate toxicity Aktuelle Neurologie. 31. DOI: 10.1055/S-2004-833373  0.61
2003 Lewerenz J, Thomsen S, Steinbeck JA, Methner A. Short-term serum supplementation improves glucose-oxygen deprivation in primary cortical cultures grown under serum-free conditions. Methods in Cell Science : An Official Journal of the Society For in Vitro Biology. 25: 227-36. PMID 15801169  0.566
2003 Lewerenz J, Gocht A, Hoeger PH, von den Driesch P, Eckert B, Lamszus K, Stuerenburg HJ, Methner A. Multiple vascular abnormalities and a paradoxical combination of vitamin B12 deficiency and thrombocytosis in a case with POEMS syndrome. Journal of Neurology. 250: 1488-91. PMID 14673584 DOI: 10.1007/s00415-003-0261-7  0.519
2003 Lewerenz J, Letz J, Methner A. Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress. Journal of Neurochemistry. 87: 522-31. PMID 14511129 DOI: 10.1046/J.1471-4159.2003.02019.X  0.667
2003 Lewerenz J, Leypoldt F, Methner A. Degenerate suppression PCR identifies the beta2-adrenergic receptor as upregulated by neuronal differentiation. Gene Expression. 11: 105-16. PMID 12837041 DOI: 10.3727/000000003108749008  0.689
2001 Methner A, Leypoldt F, Joost P, Lewerenz J. Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation. Biochemical and Biophysical Research Communications. 283: 48-56. PMID 11322766 DOI: 10.1006/Bbrc.2001.4741  0.68
2001 Leypoldt F, Lewerenz J, Methner A. Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1. Journal of Neurochemistry. 76: 806-14. PMID 11158252 DOI: 10.1046/J.1471-4159.2001.00079.X  0.704
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