Eduardo A. Nillni - Publications

Affiliations: 
Brown University, Providence, RI 
Area:
Cell Biology, Biochemistry, Physiology Biology

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cakir I, Nillni EA. Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance. Trends in Endocrinology and Metabolism: Tem. PMID 30691778 DOI: 10.1016/J.Tem.2019.01.002  0.756
2018 Yu S, Cheng H, François M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud HR, et al. Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife. 7. PMID 29761783 DOI: 10.7554/Elife.33505  0.401
2018 Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG, Qi L. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. The Journal of Clinical Investigation. PMID 29457782 DOI: 10.1172/Jci96420  0.466
2018 Yu S, Cheng H, François M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud H, et al. Author response: Preoptic leptin signaling modulates energy balance independent of body temperature regulation Elife. DOI: 10.7554/Elife.33505.023  0.339
2016 Nillni EA. The metabolic sensor Sirt1 and the hypothalamus: Interplay between peptide hormones and pro-hormone convertases. Molecular and Cellular Endocrinology. PMID 27614022 DOI: 10.1016/J.Mce.2016.09.002  0.568
2016 Toorie AM, Cyr NE, Steger JS, Beckman R, Farah G, Nillni EA. The nutrient and energy sensor Sirt1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) essential in the maturation of corticotropin releasing hormone (CRH) from its prohormone in male rats. The Journal of Biological Chemistry. PMID 26755731 DOI: 10.1074/Jbc.M115.675264  0.507
2015 Faulkner LD, Dowling AR, Stuart RC, Nillni EA, Hill JW. Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity. Endocrinology. 156: 1372-85. PMID 25590244 DOI: 10.1210/En.2014-1788  0.365
2015 Cyr NE, Steger JS, Toorie AM, Yang JZ, Stuart R, Nillni EA. Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats. Endocrinology. 156: 961-74. PMID 25549049 DOI: 10.1210/En.2014-1970  0.504
2014 Toorie AM, Nillni EA. Minireview: Central Sirt1 regulates energy balance via the melanocortin system and alternate pathways. Molecular Endocrinology (Baltimore, Md.). 28: 1423-34. PMID 24947673 DOI: 10.1210/Me.2014-1115  0.433
2014 Cyr NE, Steger JS, Toorie AM, Yang JZ, Stuart R, Nillni EA. Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats. Endocrinology. 155: 2423-35. PMID 24773342 DOI: 10.1210/En.2013-1998  0.501
2014 Mercer AJ, Stuart RC, Attard CA, Otero-Corchon V, Nillni EA, Low MJ. Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice. American Journal of Physiology. Endocrinology and Metabolism. 306: E904-15. PMID 24518677 DOI: 10.1152/Ajpendo.00540.2013  0.512
2013 Nie Y, Ferrini MG, Liu Y, Anghel A, Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 47: 99-109. PMID 23891651 DOI: 10.1016/J.Peptides.2013.07.006  0.403
2013 Cakir I, Cyr NE, Perello M, Litvinov BP, Romero A, Stuart RC, Nillni EA. Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. The Journal of Biological Chemistry. 288: 17675-88. PMID 23640886 DOI: 10.1074/Jbc.M113.475343  0.757
2013 Cyr NE, Toorie AM, Steger JS, Sochat MM, Hyner S, Perello M, Stuart R, Nillni EA. Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH. American Journal of Physiology. Endocrinology and Metabolism. 304: E640-50. PMID 23321476 DOI: 10.1152/Ajpendo.00448.2012  0.447
2013 Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu AW. AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology. 154: 172-83. PMID 23161869 DOI: 10.1210/En.2012-1643  0.417
2013 Chiappini F, Ramadoss P, Vella KR, Cunha LL, Ye FD, Stuart RC, Nillni EA, Hollenberg AN. Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus. Molecular and Cellular Endocrinology. 365: 84-94. PMID 23000398 DOI: 10.1016/J.Mce.2012.09.006  0.43
2012 Cabral A, Valdivia S, Reynaldo M, Cyr NE, Nillni EA, Perello M. Short-term cold exposure activates TRH neurons exclusively in the hypothalamic paraventricular nucleus and raphe pallidus. Neuroscience Letters. 518: 86-91. PMID 22580206 DOI: 10.1016/J.Neulet.2012.04.059  0.372
2012 Cyr NE, Stuart RC, Zhu X, Steiner DF, Nillni EA. Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice. Peptides. 35: 42-8. PMID 22421509 DOI: 10.1016/J.Peptides.2012.02.024  0.51
2011 De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK. Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American Journal of Physiology. Endocrinology and Metabolism. 300: E1002-11. PMID 21406615 DOI: 10.1152/Ajpendo.00639.2010  0.427
2011 Perello M, Çakir I, Cyr NE, Romero A, Stuart RC, Chiappini F, Hollenberg AN, Nillni EA. Maintenance of the thyroid access during diet-induced obesity in rodents is controlled at the central level (American Journal of Physiology - Endocrinology and Metabolism (2010) 299, DOI:10.1152/ajpendo.00448.2010) American Journal of Physiology - Endocrinology and Metabolism. 300: E422. DOI: 10.1152/Ajpendo.Zh1-6178-Corr.2011  0.737
2010 Perello M, Cakir I, Cyr NE, Romero A, Stuart RC, Chiappini F, Hollenberg AN, Nillni EA. Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level. American Journal of Physiology. Endocrinology and Metabolism. 299: E976-89. PMID 20858755 DOI: 10.1152/Ajpendo.00448.2010  0.769
2010 Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metabolism. 12: 78-87. PMID 20620997 DOI: 10.1016/J.Cmet.2010.05.010  0.434
2010 Nillni EA. Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. Frontiers in Neuroendocrinology. 31: 134-56. PMID 20074584 DOI: 10.1016/J.Yfrne.2010.01.001  0.5
2010 Bousquet-Moore D, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA. Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiology of Disease. 37: 130-40. PMID 19815072 DOI: 10.1016/J.Nbd.2009.09.016  0.317
2009 Cakir I, Perello M, Lansari O, Messier NJ, Vaslet CA, Nillni EA. Hypothalamic Sirt1 regulates food intake in a rodent model system. Plos One. 4: e8322. PMID 20020036 DOI: 10.1371/Journal.Pone.0008322  0.746
2009 Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk TA, Pintar JE, Eipper BA, Mains RE. Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper. Endocrinology. 150: 1739-47. PMID 19022883 DOI: 10.1210/En.2008-1202  0.41
2008 Romero A, Cakir I, Vaslet CA, Stuart RC, Lansari O, Lucero HA, Nillni EA. Role of a pro-sequence in the secretory pathway of prothyrotropin-releasing hormone. The Journal of Biological Chemistry. 283: 31438-48. PMID 18779326 DOI: 10.1074/Jbc.M803413200  0.766
2008 Espinosa VP, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart RC, Nillni EA, Lutfy K, Friedman TC. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. 156: 788-99. PMID 18771713 DOI: 10.1016/J.Neuroscience.2008.07.063  0.377
2008 Perello M, Stuart R, Nillni EA. Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway. The Journal of Biological Chemistry. 283: 19936-47. PMID 18474603 DOI: 10.1074/Jbc.M800732200  0.505
2007 Nillni EA. Regulation of prohormone convertases in hypothalamic neurons: implications for prothyrotropin-releasing hormone and proopiomelanocortin. Endocrinology. 148: 4191-200. PMID 17584972 DOI: 10.1210/En.2007-0173  0.568
2007 Perello M, Stuart RC, Vaslet CA, Nillni EA. Cold exposure increases the biosynthesis and proteolytic processing of prothyrotropin-releasing hormone in the hypothalamic paraventricular nucleus via beta-adrenoreceptors. Endocrinology. 148: 4952-64. PMID 17584968 DOI: 10.1210/En.2007-0522  0.471
2007 Perello M, Nillni EA. The biosynthesis and processing of neuropeptides: lessons from prothyrotropin releasing hormone (proTRH). Frontiers in Bioscience : a Journal and Virtual Library. 12: 3554-65. PMID 17485321 DOI: 10.2741/2334  0.556
2007 Mulcahy LR, Nillni EA. Discovery of new peptides from old prohormones: insights for energy balance and beyond. Frontiers in Bioscience : a Journal and Virtual Library. 12: 3545-53. PMID 17485320 DOI: 10.2741/2333  0.773
2007 Goldstein J, Perello M, Nillni EA. PreproThyrotropin-releasing hormone 178-199 affects tyrosine hydroxylase biosynthesis in hypothalamic neurons: a possible role for pituitary prolactin regulation. Journal of Molecular Neuroscience : Mn. 31: 69-82. PMID 17416971 DOI: 10.1007/Bf02686119  0.439
2007 Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, Glavas MM, Grayson BE, Perello M, Nillni EA, Grove KL, Cowley MA. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metabolism. 5: 181-94. PMID 17339026 DOI: 10.1016/J.Cmet.2007.02.004  0.457
2007 Perello M, Stuart RC, Nillni EA. Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract. American Journal of Physiology. Endocrinology and Metabolism. 292: E1348-57. PMID 17227963 DOI: 10.1152/Ajpendo.00466.2006  0.515
2007 Voss-Andreae A, Murphy JG, Ellacott KL, Stuart RC, Nillni EA, Cone RD, Fan W. Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology. 148: 1550-60. PMID 17194736 DOI: 10.1210/En.2006-1389  0.461
2007 Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. American Journal of Physiology. Endocrinology and Metabolism. 292: E175-86. PMID 16926379 DOI: 10.1152/Ajpendo.00288.2006  0.42
2006 Perello M, Stuart RC, Nillni EA. The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology. 147: 3296-306. PMID 16627588 DOI: 10.1210/En.2005-1533  0.403
2006 Perello M, Friedman T, Paez-Espinosa V, Shen X, Stuart RC, Nillni EA. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 147: 2705-16. PMID 16497799 DOI: 10.1210/En.2005-1609  0.47
2006 Mulcahy LR, Barker AJ, Nillni EA. Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides. Regulatory Peptides. 133: 123-33. PMID 16257458 DOI: 10.1016/J.Regpep.2005.09.027  0.777
2005 Mulcahy LR, Vaslet CA, Nillni EA. Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides. The Journal of Biological Chemistry. 280: 39818-26. PMID 16204236 DOI: 10.1074/Jbc.M507193200  0.783
2004 Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. The Journal of Clinical Investigation. 114: 357-69. PMID 15286802 DOI: 10.1172/Jci21620  0.498
2004 Guo L, Münzberg H, Stuart RC, Nillni EA, Bjørbaek C. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proceedings of the National Academy of Sciences of the United States of America. 101: 11797-802. PMID 15280541 DOI: 10.1073/Pnas.0403165101  0.473
2004 Posner SF, Vaslet CA, Jurofcik M, Lee A, Seidah NG, Nillni EA. Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1. Endocrine. 23: 199-213. PMID 15146101 DOI: 10.1385/Endo:23:2-3:199  0.486
2004 Huo L, Münzberg H, Nillni EA, Bjørbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology. 145: 2516-23. PMID 14764629 DOI: 10.1210/En.2003-1242  0.448
2004 Jing E, Nillni EA, Sanchez VC, Stuart RC, Good DJ. Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity. Endocrinology. 145: 1503-13. PMID 14701669 DOI: 10.1210/En.2003-0834  0.469
2003 Münzberg H, Huo L, Nillni EA, Hollenberg AN, Bjørbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology. 144: 2121-31. PMID 12697721 DOI: 10.1210/En.2002-221037  0.428
2003 Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37: 649-61. PMID 12597862 DOI: 10.1016/S0896-6273(03)00063-1  0.478
2002 Nillni EA, Xie W, Mulcahy L, Sanchez VC, Wetsel WC. Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. The Journal of Biological Chemistry. 277: 48587-95. PMID 12270926 DOI: 10.1074/Jbc.M206702200  0.773
2002 Nillni EA, Lee A, Legradi G, Lechan RM. Effect of precipitated morphine withdrawal on post-translational processing of prothyrotropin releasing hormone (proTRH) in the ventrolateral column of the midbrain periaqueductal gray. Journal of Neurochemistry. 80: 874-84. PMID 11948251 DOI: 10.1046/J.0022-3042.2002.00763.X  0.497
2001 Nillni EA, Aird F, Seidah NG, Todd RB, Koenig JI. PreproTRH178-199 and Two Novel Peptides (pFQ7 and pSE14) Derived from Its Processing, Which Are Produced in the Paraventricular Nucleus of the Rat Hypothalamus, Are Regulated during Suckling* *This work was supported by the National Science Foundation (Grant No. IBN-9507952 to E.A.N.). Endocrinology. 142: 896-906. PMID 28201403 DOI: 10.1210/endo.142.2.7954  0.301
2001 Nillni EA, Aird F, Seidah NG, Todd RB, Koenig JI. PreproTRH(178-199) and two novel peptides (pFQ7 and pSE14) derived from its processing, which are produced in the paraventricular nucleus of the rat hypothalamus, are regulated during suckling. Endocrinology. 142: 896-906. PMID 11159863 DOI: 10.1210/Endo.142.2.7954  0.527
2001 Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjøorbaek C, Elmquist JK, Flier JS, Hollenberg AN. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. The Journal of Clinical Investigation. 107: 111-20. PMID 11134186 DOI: 10.1172/Jci10741  0.434
2000 Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS. Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. The Journal of Biological Chemistry. 275: 36124-33. PMID 10967095 DOI: 10.1074/Jbc.M003549200  0.462
1999 Nillni EA, Steinmetz R, Pescovitz OH. Posttranslational Processing of Progrowth Hormone-Releasing Hormone1. Endocrinology. 140: 5817-5827. PMID 28200730 DOI: 10.1210/Endo.140.12.7218  0.528
1999 Nillni EA, Sevarino KA. The biology of pro-thyrotropin-releasing hormone-derived peptides. Endocrine Reviews. 20: 599-648. PMID 10529897 DOI: 10.1210/Edrv.20.5.0379  0.472
1999 Nillni EA. Neuroregulation of ProTRH biosynthesis and processing. Endocrine. 10: 185-99. PMID 10484283 DOI: 10.1007/Bf02738618  0.492
1998 Bruhn TO, Huang SS, Vaslet C, Nillni EA. Glucocorticoids modulate the biosynthesis and processing of prothyrotropin releasing-hormone (proTRH). Endocrine. 9: 143-52. PMID 9867248 DOI: 10.1385/Endo:9:2:143  0.46
1997 Schaner P, Todd RB, Seidah NG, Nillni EA. Processing of prothyrotropin-releasing hormone by the family of prohormone convertases Journal of Biological Chemistry. 272: 19958-19968. PMID 9242664 DOI: 10.1074/Jbc.272.32.19958  0.407
1996 Nillni EA, Luo LG, Jackson IM, McMillan P. Identification of the thyrotropin-releasing hormone precursor, its processing products, and its coexpression with convertase 1 in primary cultures of hypothalamic neurons: anatomic distribution of PC1 and PC2. Endocrinology. 137: 5651-61. PMID 8940396 DOI: 10.1210/Endo.137.12.8940396  0.455
1996 Légrádi G, Rand WM, Hitz S, Nillni EA, Jackson IM, Lechan RM. Opiate withdrawal increases ProTRH gene expression in the ventrolateral column of the midbrain periaqueductal gray. Brain Research. 729: 10-19. PMID 8874872 DOI: 10.1016/S0006-8993(96)00210-7  0.395
1996 Cruz IP, Nillni EA. Intracellular sites of prothyrotropin-releasing hormone processing. The Journal of Biological Chemistry. 271: 22736-45. PMID 8798448 DOI: 10.1074/Jbc.271.37.22736  0.401
1995 Friedman TC, Loh YP, Cawley NX, Birch NP, Huang SS, Jackson IM, Nillni EA. Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes. Endocrinology. 136: 4462-72. PMID 7664666 DOI: 10.1210/Endo.136.10.7664666  0.424
1995 Nillni EA, Friedman TC, Todd RB, Birch NP, Loh YP, Jackson IM. Pro-thyrotropin-releasing hormone processing by recombinant PC1. Journal of Neurochemistry. 65: 2462-72. PMID 7595540 DOI: 10.1046/J.1471-4159.1995.65062462.X  0.497
1993 Nillni EA, Sevarino KA, Jackson IM. Processing of proTRH to its intermediate products occurs before the packing into secretory granules of transfected AtT20 cells. Endocrinology. 132: 1271-7. PMID 8440188 DOI: 10.1210/Endo.132.3.8440188  0.425
1993 Nillni EA, Sevarino KA, Jackson IM. Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line. Endocrinology. 132: 1260-70. PMID 8440187 DOI: 10.1210/Endo.132.3.8440187  0.438
1991 Nillni EA, Sevarino KA, Wu P, Jackson IMD. Assays for Biosynthesis of Thyrotropin-Releasing Hormone Methods in Neurosciences. 6: 51-69. DOI: 10.1016/B978-0-12-185261-0.50009-5  0.314
Show low-probability matches.