| Year |
Citation |
Score |
| 2023 |
Zielewicz LJ, Wang J, Ndaru E, Maney B, Yu X, Albers T, Grewer C. Design and Characterization of Prodrug-like Inhibitors for Preventing Glutamate Efflux through Reverse Transport. Acs Chemical Neuroscience. PMID 37994790 DOI: 10.1021/acschemneuro.3c00651 |
0.373 |
|
| 2023 |
Dong Y, Wang J, Garibsingh RA, Hutchinson K, Shi Y, Eisenberg G, Yu X, Schlessinger A, Grewer C. Conserved allosteric inhibition mechanism in SLC1 transporters. Elife. 12. PMID 36856089 DOI: 10.7554/eLife.83464 |
0.424 |
|
| 2022 |
Ndaru E, Zielewicz L, Shi Y, Hutchinson K, Garibsingh RA, Schlessinger A, Grewer C. Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters. Journal of Physical Organic Chemistry. 35. PMID 36568026 DOI: 10.1002/poc.4347 |
0.369 |
|
| 2022 |
Wang J, Dong Y, Grewer C. Functional and Kinetic Comparison of Alanine Cysteine Serine Transporters ASCT1 and ASCT2. Biomolecules. 12. PMID 35053261 DOI: 10.3390/biom12010113 |
0.372 |
|
| 2021 |
Shi Y, Wang J, Ndaru E, Grewer C. Pre-steady-state Kinetic Analysis of Amino Acid Transporter SLC6A14 Reveals Rapid Turnover Rate and Substrate Translocation. Frontiers in Physiology. 12: 777050. PMID 34867484 DOI: 10.3389/fphys.2021.777050 |
0.355 |
|
| 2021 |
Wang J, Li P, Yu X, Grewer C. Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters. Plos One. 16: e0250635. PMID 33891665 DOI: 10.1371/journal.pone.0250635 |
0.374 |
|
| 2021 |
Wang J, Zielewicz L, Dong Y, Grewer C. Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain. Neurochemical Research. PMID 33550531 DOI: 10.1007/s11064-021-03247-8 |
0.365 |
|
| 2019 |
Zielewicz L, Grewer CT. Genetically-encoded halide sensor-based fluorescent assay for rapid screening of glutamate transport and inhibition. Acs Sensors. PMID 31393114 DOI: 10.1021/acssensors.9b00944 |
0.361 |
|
| 2019 |
Wang J, Zielewicz L, Grewer C. A K/Na co-binding state: Simultaneous versus competitive binding of K and Na to glutamate transporters. The Journal of Biological Chemistry. PMID 31235523 DOI: 10.1074/jbc.RA119.009421 |
0.33 |
|
| 2019 |
Zielewicz L, Wang J, Ndaru E, Grewer CT. Transient kinetics reveal mechanism and voltage dependence of inhibitor and substrate binding to glutamate transporters. Acs Chemical Biology. PMID 31026143 DOI: 10.1021/acschembio.9b00194 |
0.37 |
|
| 2019 |
Ndaru E, Garibsingh RA, Shi Y, Wallace E, Zakrepine P, Wang J, Schlessinger A, Grewer C. Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds. The Journal of General Physiology. PMID 30718375 DOI: 10.1085/jgp.201812276 |
0.387 |
|
| 2019 |
Zielewicz LJ, Wang J, Ndaru E, Grewer CT. Voltage Dependent Inhibitor Binding to Plasma-Membrane Glutamate Transporters Biophysical Journal. 116: 556a. DOI: 10.1016/j.bpj.2018.11.2992 |
0.309 |
|
| 2019 |
Wang J, Grewer CT. Mechanism and Potential Sites of Potassium Interaction with the Glutamate Transporter EAAC1 Biophysical Journal. 116: 556a. DOI: 10.1016/j.bpj.2018.11.2991 |
0.317 |
|
| 2017 |
Wang J, Albers T, Grewer CT. Energy Landscape of the Substrate Translocation Equilibrium of Plasma-Membrane Glutamate Transporters. The Journal of Physical Chemistry. B. PMID 29218993 DOI: 10.1021/acs.jpcb.7b09059 |
0.357 |
|
| 2016 |
Singh K, Tanui R, Gameiro A, Eisenberg G, Colas C, Schlessinger A, Grewer C. Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2. Bioorganic & Medicinal Chemistry Letters. PMID 28057420 DOI: 10.1016/J.Bmcl.2016.12.063 |
0.576 |
|
| 2016 |
Tanui R, Tao Z, Silverstein N, Kanner B, Grewer C. Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1. The Journal of Biological Chemistry. PMID 27044739 DOI: 10.1074/jbc.M116.722470 |
0.391 |
|
| 2015 |
Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K, Shere H, Bonomi M, Holst J, Schlessinger A. Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening. Plos Computational Biology. 11: e1004477. PMID 26444490 DOI: 10.1371/Journal.Pcbi.1004477 |
0.6 |
|
| 2014 |
Grewer C, Gameiro A. How do glutamate transporters function as transporters and ion channels? Biophysical Journal. 107: 546-7. PMID 25099793 DOI: 10.1016/J.Bpj.2014.06.027 |
0.592 |
|
| 2014 |
Grewer C, Gameiro A, Rauen T. SLC1 glutamate transporters. Pflã¼Gers Archiv : European Journal of Physiology. 466: 3-24. PMID 24240778 DOI: 10.1007/S00424-013-1397-7 |
0.608 |
|
| 2013 |
Zander CB, Albers T, Grewer C. Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2. The Journal of General Physiology. 141: 659-72. PMID 23669717 DOI: 10.1085/Jgp.201210948 |
0.341 |
|
| 2013 |
Grewer C, Gameiro A, Mager T, Fendler K. Electrophysiological characterization of membrane transport proteins. Annual Review of Biophysics. 42: 95-120. PMID 23451896 DOI: 10.1146/Annurev-Biophys-083012-130312 |
0.561 |
|
| 2013 |
Zander CB, Kim YJ, Grewer C. Conserved Residues Serine 225 and Methionine 229 Attenuate the Sodium Transport Responses in the Sodium-Coupled Neutral Amino Acid Transporter, SNAT2 Biophysical Journal. 104: 111a-112a. DOI: 10.1016/J.Bpj.2012.11.647 |
0.353 |
|
| 2013 |
Mwaura J, Tao Z, James H, Albers T, Schwartz A, Grewer C. Is ASP-454 Necessary for Na+ and K+ Binding in the Glutamate Transporter EAAC1? Biophysical Journal. 104: 109a. DOI: 10.1016/j.bpj.2012.11.634 |
0.33 |
|
| 2012 |
Mwaura J, Tao Z, James H, Albers T, Schwartz A, Grewer C. Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1. Acs Chemical Neuroscience. 3: 1073-83. PMID 23259042 DOI: 10.1021/cn300163p |
0.374 |
|
| 2012 |
Grewer C, Zhang Z, Mwaura J, Albers T, Schwartz A, Gameiro A. Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter. The Journal of Biological Chemistry. 287: 26921-31. PMID 22707712 DOI: 10.1074/Jbc.M112.364059 |
0.563 |
|
| 2012 |
Callender R, Gameiro A, Pinto A, De Micheli C, Grewer C. Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B. Biochemistry. 51: 5486-95. PMID 22703277 DOI: 10.1021/Bi3006048 |
0.618 |
|
| 2012 |
Albers T, Marsiglia W, Thomas T, Gameiro A, Grewer C. Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine Analogs. Molecular Pharmacology. 81: 356-65. PMID 22113081 DOI: 10.1124/Mol.111.075648 |
0.628 |
|
| 2012 |
Grewer C, Gameiro A, Mwaura J. Charge Compensation Mechanism of Glutamate Transport Biophysical Journal. 102: 522a. DOI: 10.1016/J.Bpj.2011.11.2855 |
0.572 |
|
| 2011 |
Rosental N, Gameiro A, Grewer C, Kanner BI. A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters. The Journal of Biological Chemistry. 286: 41381-90. PMID 21984827 DOI: 10.1074/Jbc.M111.291021 |
0.63 |
|
| 2011 |
Gameiro A, Braams S, Rauen T, Grewer C. The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5. Biophysical Journal. 100: 2623-32. PMID 21641307 DOI: 10.1016/J.Bpj.2011.04.034 |
0.632 |
|
| 2011 |
Zhang Z, Zander CB, Grewer C. The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes. The Biochemical Journal. 434: 287-96. PMID 21158741 DOI: 10.1042/Bj20100507 |
0.35 |
|
| 2011 |
Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C. Hetero-oligomerization of neuronal glutamate transporters. The Journal of Biological Chemistry. 286: 3935-43. PMID 21127051 DOI: 10.1074/Jbc.M110.187492 |
0.601 |
|
| 2010 |
Tao Z, Rosental N, Kanner BI, Gameiro A, Mwaura J, Grewer C. Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. The Journal of Biological Chemistry. 285: 17725-33. PMID 20378543 DOI: 10.1074/Jbc.M110.121798 |
0.628 |
|
| 2010 |
Albers T, Gameiro A, Thomas T, Grewer C. Structure-Function Relationships of Inhibitors for the EAAC1 and ASCT2 Amino Acid Transporters Biophysical Journal. 98: 506a. DOI: 10.1016/J.Bpj.2009.12.2756 |
0.619 |
|
| 2009 |
Zhang Z, Albers T, Fiumera HL, Gameiro A, Grewer C. A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). The Journal of Biological Chemistry. 284: 25314-23. PMID 19589777 DOI: 10.1074/Jbc.M109.038422 |
0.604 |
|
| 2008 |
Tao Z, Gameiro A, Grewer C. Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1. Biochemistry. 47: 12923-30. PMID 18986164 DOI: 10.1021/Bi8017174 |
0.633 |
|
| 2008 |
Grewer C, Gameiro A, Zhang Z, Tao Z, Braams S, Rauen T. Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. Iubmb Life. 60: 609-19. PMID 18543277 DOI: 10.1002/Iub.98 |
0.586 |
|
| 2008 |
Zhang Z, Gameiro A, Grewer C. Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2. The Journal of Biological Chemistry. 283: 12284-92. PMID 18319257 DOI: 10.1074/Jbc.M706774200 |
0.572 |
|
| 2007 |
Zhang Z, Tao Z, Gameiro A, Barcelona S, Braams S, Rauen T, Grewer C. Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1. Proceedings of the National Academy of Sciences of the United States of America. 104: 18025-30. PMID 17991780 DOI: 10.1073/Pnas.0704570104 |
0.631 |
|
| 2007 |
Mim C, Tao Z, Grewer C. Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1. Biochemistry. 46: 9007-18. PMID 17630698 DOI: 10.1021/bi7005465 |
0.391 |
|
| 2007 |
Tao Z, Grewer C. Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1. The Journal of General Physiology. 129: 331-44. PMID 17389249 DOI: 10.1085/jgp.200609678 |
0.415 |
|
| 2007 |
Zhang Z, Papageorgiou G, Corrie JE, Grewer C. Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative. Biochemistry. 46: 3872-80. PMID 17311416 DOI: 10.1021/bi0620860 |
0.365 |
|
| 2007 |
Zhang Z, Grewer C. The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophysical Journal. 92: 2621-32. PMID 17237199 DOI: 10.1529/biophysj.106.100776 |
0.351 |
|
| 2007 |
Maier W, Schemm R, Grewer C, Laube B. Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation. The Journal of Biological Chemistry. 282: 1863-72. PMID 17105731 DOI: 10.1074/jbc.M608156200 |
0.341 |
|
| 2006 |
Tao Z, Zhang Z, Grewer C. Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. The Journal of Biological Chemistry. 281: 10263-72. PMID 16478724 DOI: 10.1074/jbc.M510739200 |
0.381 |
|
| 2005 |
Mim C, Balani P, Rauen T, Grewer C. The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism. The Journal of General Physiology. 126: 571-89. PMID 16316976 DOI: 10.1085/jgp.200509365 |
0.386 |
|
| 2005 |
Grewer C, Balani P, Weidenfeller C, Bartusel T, Tao Z, Rauen T. Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. Biochemistry. 44: 11913-23. PMID 16128593 DOI: 10.1021/bi050987n |
0.363 |
|
| 2005 |
Grewer C, Rauen T. Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling. The Journal of Membrane Biology. 203: 1-20. PMID 15834685 DOI: 10.1007/s00232-004-0731-6 |
0.352 |
|
| 2005 |
Tao Z, Grewer C. The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1. Biochemistry. 44: 3466-76. PMID 15736956 DOI: 10.1021/bi047812i |
0.358 |
|
| 2005 |
Maier W, Corrie JE, Papageorgiou G, Laube B, Grewer C. Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor. Journal of Neuroscience Methods. 142: 1-9. PMID 15652611 DOI: 10.1016/j.jneumeth.2004.07.006 |
0.318 |
|
| 2004 |
Breitinger HG, Lanig H, Vohwinkel C, Grewer C, Breitinger U, Clark T, Becker CM. Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor. Chemistry & Biology. 11: 1339-50. PMID 15489161 DOI: 10.1016/J.Chembiol.2004.07.008 |
0.638 |
|
| 2004 |
Grewer C, Grabsch E. New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. The Journal of Physiology. 557: 747-59. PMID 15107471 DOI: 10.1113/jphysiol.2004.062521 |
0.384 |
|
| 2003 |
Banerjee A, Grewer C, Ramakrishnan L, Jäger J, Gameiro A, Breitinger HG, Gee KR, Carpenter BK, Hess GP. Toward the development of new photolabile protecting groups that can rapidly release bioactive compounds upon photolysis with visible light. The Journal of Organic Chemistry. 68: 8361-7. PMID 14575458 DOI: 10.1021/Jo0300643 |
0.657 |
|
| 2003 |
Grewer C, Watzke N, Rauen T, Bicho A. Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1? The Journal of Biological Chemistry. 278: 2585-92. PMID 12419818 DOI: 10.1074/jbc.M207956200 |
0.409 |
|
| 2002 |
Schaper K, Abdollah Madani Mobarekeh S, Grewer C. Synthesis and photophysical characterization of a new, highly hydrophilic caging group European Journal of Organic Chemistry. 1037-1046. |
0.492 |
|
| 2001 |
Watzke N, Grewer C. The anion conductance of the glutamate transporter EAAC1 depends on the direction of glutamate transport. Febs Letters. 503: 121-5. PMID 11513867 DOI: 10.1016/S0014-5793(01)02715-6 |
0.376 |
|
| 2001 |
Campiani G, De Angelis M, Armaroli S, Fattorusso C, Catalanotti B, Ramunno A, Nacci V, Novellino E, Grewer C, Ionescu D, Rauen T, Griffiths R, Sinclair C, Fumagalli E, Mennini T. A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents. Journal of Medicinal Chemistry. 44: 2507-10. PMID 11472204 DOI: 10.1021/Jm015509Z |
0.315 |
|
| 2001 |
Watzke N, Bamberg E, Grewer C. Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1. The Journal of General Physiology. 117: 547-62. PMID 11382805 DOI: 10.1085/Jgp.117.6.547 |
0.402 |
|
| 2001 |
Grewer C, Madani Mobarekeh SA, Watzke N, Rauen T, Schaper K. Substrate translocation kinetics of excitatory amino acid carrier 1 probed with laser-pulse photolysis of a new photolabile precursor of D-aspartic acid. Biochemistry. 40: 232-40. PMID 11141075 DOI: 10.1021/bi0015919 |
0.596 |
|
| 2000 |
Hess GP, Ulrich H, Breitinger HG, Niu L, Gameiro AM, Grewer C, Srivastava S, Ippolito JE, Lee SM, Jayaraman V, Coombs SE. Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801. Proceedings of the National Academy of Sciences of the United States of America. 97: 13895-900. PMID 11095713 DOI: 10.1073/Pnas.240459497 |
0.691 |
|
| 2000 |
Watzke N, Rauen T, Bamberg E, Grewer C. On the mechanism of proton transport by the neuronal excitatory amino acid carrier 1. The Journal of General Physiology. 116: 609-22. PMID 11055990 DOI: 10.1085/jgp.116.5.609 |
0.409 |
|
| 2000 |
Grewer C, Watzke N, Wiessner M, Rauen T. Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds. Proceedings of the National Academy of Sciences of the United States of America. 97: 9706-11. PMID 10931942 DOI: 10.1073/pnas.160170397 |
0.369 |
|
| 2000 |
Grewer C, Jäger J, Carpenter BK, Hess GP. A new photolabile precursor of glycine with improved properties: A tool for chemical kinetic investigations of the glycine receptor. Biochemistry. 39: 2063-70. PMID 10684656 DOI: 10.1021/Bi9919652 |
0.633 |
|
| 1999 |
Grewer C. Investigation of the alpha(1)-glycine receptor channel-opening kinetics in the submillisecond time domain. Biophysical Journal. 77: 727-38. PMID 10423421 DOI: 10.1016/S0006-3495(99)76927-4 |
0.329 |
|
| 1999 |
Grewer C, Hess GP. On the mechanism of inhibition of the nicotinic acetylcholine receptor by the anticonvulsant MK-801 investigated by laser-pulse photolysis in the microsecond-to-millisecond time region. Biochemistry. 38: 7837-46. PMID 10387024 DOI: 10.1021/Bi9827767 |
0.625 |
|
| 1998 |
Hess GP, Grewer C. Development and application of caged ligands for neurotransmitter receptors in transient kinetic and neuronal circuit mapping studies. Methods in Enzymology. 291: 443-73. PMID 9661164 DOI: 10.1016/S0076-6879(98)91028-X |
0.595 |
|
| 1996 |
Niu L, Grewer C, Hess GP. Chemical kinetic investigations of neurotransmitter receptors on a cell Surface in the μs time region Techniques in Protein Chemistry. 7: 139-149. DOI: 10.1016/S1080-8914(96)80018-4 |
0.677 |
|
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