Christof Grewer, Ph.D. - Publications

Affiliations: 
Binghamton University, Vestal, NY, United States 

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ndaru E, Garibsingh RA, Zielewicz L, Schlessinger A, Grewer C. Interaction of the neutral amino acid transporter ASCT2 with basic amino acids. The Biochemical Journal. PMID 32242892 DOI: 10.1042/BCJ20190859  0.32
2019 Ndaru E, Garibsingh RA, Shi Y, Wallace E, Zakrepine P, Wang J, Schlessinger A, Grewer C. Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds. The Journal of General Physiology. PMID 30718375 DOI: 10.1085/jgp.201812276  0.32
2018 Garibsingh RA, Otte NJ, Ndaru E, Colas C, Grewer C, Holst J, Schlessinger A. Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2. Frontiers in Chemistry. 6: 279. PMID 30137742 DOI: 10.3389/fchem.2018.00279  0.32
2017 Wang J, Albers T, Grewer CT. Energy Landscape of the Substrate Translocation Equilibrium of Plasma-Membrane Glutamate Transporters. The Journal of Physical Chemistry. B. PMID 29218993 DOI: 10.1021/acs.jpcb.7b09059  0.52
2016 Singh K, Tanui R, Gameiro A, Eisenberg G, Colas C, Schlessinger A, Grewer C. Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2. Bioorganic & Medicinal Chemistry Letters. PMID 28057420 DOI: 10.1016/j.bmcl.2016.12.063  1
2016 Chen C, Wang J, Cai R, Yuan Y, Guo Z, Grewer C, Zhang Z. Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification. Plos One. 11: e0158319. PMID 27355203 DOI: 10.1371/journal.pone.0158319  0.56
2016 Tanui R, Tao Z, Silverstein N, Kanner B, Grewer C. Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1. The Journal of Biological Chemistry. PMID 27044739 DOI: 10.1074/jbc.M116.722470  0.56
2015 Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K, Shere H, Bonomi M, Holst J, Schlessinger A. Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening. Plos Computational Biology. 11: e1004477. PMID 26444490 DOI: 10.1371/journal.pcbi.1004477  1
2015 Zander C, Zhang Z, Albers T, Grewer C. Amino acid transporters and glutamine Glutamine in Clinical Nutrition. 21-36. DOI: 10.1007/978-1-4939-1932-1_2  1
2014 Grewer C, Gameiro A. How do glutamate transporters function as transporters and ion channels? Biophysical Journal. 107: 546-7. PMID 25099793 DOI: 10.1016/j.bpj.2014.06.027  1
2014 Grewer C. Shedding light on conformational dynamics of na(+)-coupled transporters. Biophysical Journal. 106: 1549-50. PMID 24739150 DOI: 10.1016/j.bpj.2014.02.029  1
2014 Grewer C, Gameiro A, Rauen T. SLC1 glutamate transporters. PflüGers Archiv : European Journal of Physiology. 466: 3-24. PMID 24240778 DOI: 10.1007/s00424-013-1397-7  1
2013 Muse O, Zengeya T, Mwaura J, Hnedzko D, McGee DW, Grewer CT, Rozners E. Sequence selective recognition of double-stranded RNA at physiologically relevant conditions using PNA-peptide conjugates. Acs Chemical Biology. 8: 1683-6. PMID 23721369 DOI: 10.1021/cb400144x  1
2013 Zander CB, Albers T, Grewer C. Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2. The Journal of General Physiology. 141: 659-72. PMID 23669717 DOI: 10.1085/jgp.201210948  1
2013 Grewer C, Gameiro A, Mager T, Fendler K. Electrophysiological characterization of membrane transport proteins. Annual Review of Biophysics. 42: 95-120. PMID 23451896 DOI: 10.1146/annurev-biophys-083012-130312  1
2012 Mwaura J, Tao Z, James H, Albers T, Schwartz A, Grewer C. Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1. Acs Chemical Neuroscience. 3: 1073-83. PMID 23259042 DOI: 10.1021/cn300163p  1
2012 Grewer C, Zhang Z, Mwaura J, Albers T, Schwartz A, Gameiro A. Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter. The Journal of Biological Chemistry. 287: 26921-31. PMID 22707712 DOI: 10.1074/jbc.M112.364059  1
2012 Callender R, Gameiro A, Pinto A, De Micheli C, Grewer C. Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B. Biochemistry. 51: 5486-95. PMID 22703277 DOI: 10.1021/bi3006048  1
2012 Albers T, Marsiglia W, Thomas T, Gameiro A, Grewer C. Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine Analogs. Molecular Pharmacology. 81: 356-65. PMID 22113081 DOI: 10.1124/mol.111.075648  1
2011 Rosental N, Gameiro A, Grewer C, Kanner BI. A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters. The Journal of Biological Chemistry. 286: 41381-90. PMID 21984827 DOI: 10.1074/jbc.M111.291021  1
2011 Gameiro A, Braams S, Rauen T, Grewer C. The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5. Biophysical Journal. 100: 2623-32. PMID 21641307 DOI: 10.1016/j.bpj.2011.04.034  1
2011 Zhang Z, Zander CB, Grewer C. The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes. The Biochemical Journal. 434: 287-96. PMID 21158741 DOI: 10.1042/BJ20100507  1
2011 Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C. Hetero-oligomerization of neuronal glutamate transporters. The Journal of Biological Chemistry. 286: 3935-43. PMID 21127051 DOI: 10.1074/jbc.M110.187492  1
2010 Tao Z, Rosental N, Kanner BI, Gameiro A, Mwaura J, Grewer C. Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. The Journal of Biological Chemistry. 285: 17725-33. PMID 20378543 DOI: 10.1074/jbc.M110.121798  1
2009 Zhang Z, Albers T, Fiumera HL, Gameiro A, Grewer C. A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). The Journal of Biological Chemistry. 284: 25314-23. PMID 19589777 DOI: 10.1074/jbc.M109.038422  1
2008 Tao Z, Gameiro A, Grewer C. Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1. Biochemistry. 47: 12923-30. PMID 18986164 DOI: 10.1021/bi8017174  1
2008 Grewer C, Gameiro A, Zhang Z, Tao Z, Braams S, Rauen T. Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. Iubmb Life. 60: 609-19. PMID 18543277 DOI: 10.1002/iub.98  1
2008 Zhang Z, Gameiro A, Grewer C. Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2. The Journal of Biological Chemistry. 283: 12284-92. PMID 18319257 DOI: 10.1074/jbc.M706774200  1
2008 Erreger K, Grewer C, Javitch JA, Galli A. Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 976-89. PMID 18216205 DOI: 10.1523/JNEUROSCI.2796-07.2008  1
2007 Zhang Z, Tao Z, Gameiro A, Barcelona S, Braams S, Rauen T, Grewer C. Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1. Proceedings of the National Academy of Sciences of the United States of America. 104: 18025-30. PMID 17991780 DOI: 10.1073/pnas.0704570104  1
2007 Mim C, Tao Z, Grewer C. Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1. Biochemistry. 46: 9007-18. PMID 17630698 DOI: 10.1021/bi7005465  1
2007 Tao Z, Grewer C. Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1. The Journal of General Physiology. 129: 331-44. PMID 17389249 DOI: 10.1085/jgp.200609678  1
2007 Zhang Z, Papageorgiou G, Corrie JE, Grewer C. Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative. Biochemistry. 46: 3872-80. PMID 17311416 DOI: 10.1021/bi0620860  1
2007 Zhang Z, Grewer C. The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophysical Journal. 92: 2621-32. PMID 17237199 DOI: 10.1529/biophysj.106.100776  1
2007 Maier W, Schemm R, Grewer C, Laube B. Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation. The Journal of Biological Chemistry. 282: 1863-72. PMID 17105731 DOI: 10.1074/jbc.M608156200  1
2006 Tao Z, Zhang Z, Grewer C. Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. The Journal of Biological Chemistry. 281: 10263-72. PMID 16478724 DOI: 10.1074/jbc.M510739200  1
2005 Mim C, Balani P, Rauen T, Grewer C. The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism. The Journal of General Physiology. 126: 571-89. PMID 16316976 DOI: 10.1085/jgp.200509365  1
2005 Grewer C, Balani P, Weidenfeller C, Bartusel T, Tao Z, Rauen T. Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. Biochemistry. 44: 11913-23. PMID 16128593 DOI: 10.1021/bi050987n  1
2005 Bicho A, Grewer C. Rapid substrate-induced charge movements of the GABA transporter GAT1. Biophysical Journal. 89: 211-31. PMID 15849242 DOI: 10.1529/biophysj.105.061002  1
2005 Grewer C, Rauen T. Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling. The Journal of Membrane Biology. 203: 1-20. PMID 15834685 DOI: 10.1007/s00232-004-0731-6  0.68
2005 Tao Z, Grewer C. The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1. Biochemistry. 44: 3466-76. PMID 15736956 DOI: 10.1021/bi047812i  1
2005 Maier W, Corrie JE, Papageorgiou G, Laube B, Grewer C. Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor. Journal of Neuroscience Methods. 142: 1-9. PMID 15652611 DOI: 10.1016/j.jneumeth.2004.07.006  1
2004 Breitinger HG, Lanig H, Vohwinkel C, Grewer C, Breitinger U, Clark T, Becker CM. Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor. Chemistry & Biology. 11: 1339-50. PMID 15489161 DOI: 10.1016/j.chembiol.2004.07.008  1
2004 Grewer C, Grabsch E. New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. The Journal of Physiology. 557: 747-59. PMID 15107471 DOI: 10.1113/jphysiol.2004.062521  1
2004 Sullivan R, Rauen T, Fischer F, Wiessner M, Grewer C, Bicho A, Pow DV. Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis. Glia. 45: 155-69. PMID 14730709 DOI: 10.1002/glia.10317  1
2003 Banerjee A, Grewer C, Ramakrishnan L, Jäger J, Gameiro A, Breitinger HG, Gee KR, Carpenter BK, Hess GP. Toward the development of new photolabile protecting groups that can rapidly release bioactive compounds upon photolysis with visible light. The Journal of Organic Chemistry. 68: 8361-7. PMID 14575458 DOI: 10.1021/jo0300643  1
2003 Grewer C, Watzke N, Rauen T, Bicho A. Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1? The Journal of Biological Chemistry. 278: 2585-92. PMID 12419818 DOI: 10.1074/jbc.M207956200  1
2002 Schaper K, Abdollah Madani Mobarekeh S, Grewer C. Synthesis and photophysical characterization of a new, highly hydrophilic caging group European Journal of Organic Chemistry. 1037-1046.  1
2001 Watzke N, Grewer C. The anion conductance of the glutamate transporter EAAC1 depends on the direction of glutamate transport. Febs Letters. 503: 121-5. PMID 11513867 DOI: 10.1016/S0014-5793(01)02715-6  0.64
2001 Campiani G, De Angelis M, Armaroli S, Fattorusso C, Catalanotti B, Ramunno A, Nacci V, Novellino E, Grewer C, Ionescu D, Rauen T, Griffiths R, Sinclair C, Fumagalli E, Mennini T. A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents. Journal of Medicinal Chemistry. 44: 2507-10. PMID 11472204 DOI: 10.1021/jm015509z  1
2001 Watzke N, Bamberg E, Grewer C. Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1. The Journal of General Physiology. 117: 547-62. PMID 11382805 DOI: 10.1085/jgp.117.6.547  1
2001 Grewer C, Madani Mobarekeh SA, Watzke N, Rauen T, Schaper K. Substrate translocation kinetics of excitatory amino acid carrier 1 probed with laser-pulse photolysis of a new photolabile precursor of D-aspartic acid. Biochemistry. 40: 232-40. PMID 11141075 DOI: 10.1021/bi0015919  1
2000 Hess GP, Ulrich H, Breitinger HG, Niu L, Gameiro AM, Grewer C, Srivastava S, Ippolito JE, Lee SM, Jayaraman V, Coombs SE. Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801. Proceedings of the National Academy of Sciences of the United States of America. 97: 13895-900. PMID 11095713 DOI: 10.1073/pnas.240459497  1
2000 Watzke N, Rauen T, Bamberg E, Grewer C. On the mechanism of proton transport by the neuronal excitatory amino acid carrier 1. The Journal of General Physiology. 116: 609-22. PMID 11055990 DOI: 10.1085/jgp.116.5.609  1
2000 Grewer C, Watzke N, Wiessner M, Rauen T. Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds. Proceedings of the National Academy of Sciences of the United States of America. 97: 9706-11. PMID 10931942 DOI: 10.1073/pnas.160170397  1
2000 Grewer C, Jäger J, Carpenter BK, Hess GP. A new photolabile precursor of glycine with improved properties: A tool for chemical kinetic investigations of the glycine receptor. Biochemistry. 39: 2063-70. PMID 10684656 DOI: 10.1021/bi9919652  1
1999 Grewer C, Hess GP. On the mechanism of inhibition of the nicotinic acetylcholine receptor by the anticonvulsant MK-801 investigated by laser-pulse photolysis in the microsecond-to-millisecond time region. Biochemistry. 38: 7837-46. PMID 10387024 DOI: 10.1021/bi9827767  1
1998 Hess GP, Grewer C. Development and application of caged ligands for neurotransmitter receptors in transient kinetic and neuronal circuit mapping studies. Methods in Enzymology. 291: 443-73. PMID 9661164 DOI: 10.1016/S0076-6879(98)91028-X  1
1996 Niu L, Grewer C, Hess GP. Chemical kinetic investigations of neurotransmitter receptors on a cell Surface in the μs time region Techniques in Protein Chemistry. 7: 139-149. DOI: 10.1016/S1080-8914(96)80018-4  1
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