Philippe Seguela - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lançon K, Qu C, Navratilova E, Porreca F, Séguéla P. Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain. Cell Reports. 37: 109933. PMID 34852233 DOI: 10.1016/j.celrep.2021.109933  0.372
2020 Sharif B, Ase AR, Ribeiro-da-Silva A, Séguéla P. Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons. Neuron. PMID 32298640 DOI: 10.1016/J.Neuron.2020.03.021  0.473
2020 Bertin E, Deluc T, Pilch KS, Martinez A, Pougnet JT, Doudnikoff E, Allain AE, Bergmann P, Russeau M, Toulmé E, Bezard E, Koch-Nolte F, Séguéla P, Lévi S, Bontempi B, et al. Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice. Molecular Psychiatry. PMID 31911635 DOI: 10.1038/s41380-019-0641-8  0.394
2019 Petitjean H, Séguéla P, Sharif-Naeini R. Bursting Enables GRP Neurons to Engage Spinal Itch Circuits. Neuron. 103: 546. PMID 31394064 DOI: 10.1016/J.Neuron.2019.07.012  0.347
2019 Ase AR, Therrien É, Séguéla P. An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels. Frontiers in Cellular Neuroscience. 13: 121. PMID 31024257 DOI: 10.3389/Fncel.2019.00121  0.425
2018 Waataja JJ, Peterson CD, Verma H, Goracke-Postle CJ, Séguéla P, Delpire E, Wilcox GL, Fairbanks CA. Agmatine Preferentially Antagonizes GluN2B-Containing N-Methyl-D-Aspartate Receptors in Spinal Cord. Journal of Neurophysiology. PMID 30427758 DOI: 10.1152/Jn.00172.2018  0.371
2018 Glasgow SD, Labrecque S, Beamish IV, Aufmkolk S, Gibon J, Han D, Harris SN, Dufresne P, Wiseman PW, McKinney RA, Séguéla P, De Koninck P, Ruthazer ES, Kennedy TE. Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus. Cell Reports. 25: 168-182.e6. PMID 30282026 DOI: 10.1016/J.Celrep.2018.09.028  0.324
2018 Dunn TW, Fan X, Ase AR, Séguéla P, Sossin WS. The Ca2α1 EF-hand F helix tyrosine, a highly conserved locus for GPCR inhibition of Ca2 channels. Scientific Reports. 8: 3263. PMID 29459734 DOI: 10.1038/S41598-018-21586-5  0.33
2017 Cordeiro Matos S, Zamfir M, Longo G, Ribeiro-da-Silva A, Séguéla P. Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. Brain Structure & Function. PMID 29094305 DOI: 10.1007/S00429-017-1543-7  0.36
2017 Bernier LP, Ase AR, Séguéla P. P2X receptor-channels in chronic pain pathways. British Journal of Pharmacology. PMID 28728214 DOI: 10.1111/Bph.13957  0.363
2017 Beaudry H, Daou I, Ribeiro-da-Silva A, Séguéla P. Will optogenetics be used to treat chronic pain patients? Pain Management. PMID 28726577 DOI: 10.2217/Pmt-2016-0055  0.701
2017 Beaudry H, Daou I, Ase AR, Ribeiro-da-Silva A, Séguéla P. Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers. Pain. PMID 28708765 DOI: 10.1097/J.Pain.0000000000001016  0.71
2017 Uhelski ML, Bruce DJ, Seguela P, Wilcox GL, Simone DA. In vivo optogenetic activation of Nav1.8+ cutaneous nociceptors and their responses to natural stimuli. Journal of Neurophysiology. jn.00083.2017. PMID 28298301 DOI: 10.1152/Jn.00083.2017  0.379
2016 Gibon J, Kang MS, Aliaga A, Sharif B, Rosa-Neto P, Séguéla P, Barker PA, Kostikov A. Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorganic & Medicinal Chemistry. PMID 27567078 DOI: 10.1016/j.bmc.2016.08.020  0.34
2016 Daou I, Beaudry H, Ase AR, Wieskopf JS, Ribeiro-da-Silva A, Mogil JS, Séguéla P. Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain. Eneuro. 3. PMID 27022626 DOI: 10.1523/ENEURO.0140-15.2016  0.715
2016 Gaub P, de Léon A, Gibon J, Soubannier V, Dorval G, Séguéla P, Barker PA. HBpF-proBDNF: A New Tool for the Analysis of Pro-Brain Derived Neurotrophic Factor Receptor Signaling and Cell Biology. Plos One. 11: e0150601. PMID 26950209 DOI: 10.1371/Journal.Pone.0150601  0.34
2016 Gibon J, Barker PA, Séguéla P. Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex. Molecular Brain. 9: 23. PMID 26932787 DOI: 10.1186/S13041-016-0203-9  0.343
2016 Beaudry H, Daou I, Ribeiro-Da-Silva A, Séguéla P. (367) Interrogating the role of peripheral opioid receptors using an optogenetic approach The Journal of Pain. 17: S67. DOI: 10.1016/J.Jpain.2016.01.274  0.303
2016 Beaudry H, Daou I, Ribeiro-da-Silva A, Séguéla P. Optogénétique et douleur chronique : une stratégie applicable chez l’humain ? Douleur Et AnalgéSie. 29: 232-240. DOI: 10.1007/S11724-016-0477-9  0.641
2015 Cordeiro Matos S, Zhang Z, Séguéla P. Peripheral Neuropathy Induces HCN Channel Dysfunction in Pyramidal Neurons of the Medial Prefrontal Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13244-56. PMID 26400952 DOI: 10.1523/JNEUROSCI.0799-15.2015  0.483
2015 Gibon J, Buckley SM, Unsain N, Kaartinen V, Séguéla P, Barker PA. proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9741-53. PMID 26134656 DOI: 10.1523/Jneurosci.4655-14.2015  0.402
2015 Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2Y12 expression and function in alternatively activated human microglia. Neurology® Neuroimmunology & Neuroinflammation. 2: e80. PMID 25821842 DOI: 10.1212/Nxi.0000000000000080  0.302
2015 Ase AR, Honson NS, Zaghdane H, Pfeifer TA, Séguéla P. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Molecular Pharmacology. 87: 606-16. PMID 25597706 DOI: 10.1124/Mol.114.096222  0.429
2015 Beaudry H, Ribeiro-Da-Silva A, Seguela P. (353) A direct role of the sympathetic nervous system in chronic pain? An optogenetic approach The Journal of Pain. 16: S64. DOI: 10.1016/J.Jpain.2015.01.271  0.692
2014 Alkhani H, Ase AR, Grant R, O'Donnell D, Groschner K, Séguéla P. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Molecular Pain. 10: 43. PMID 24965271 DOI: 10.1186/1744-8069-10-43  0.418
2013 Bernier LP, Ase AR, Séguéla P. Post-translational regulation of P2X receptor channels: modulation by phospholipids. Frontiers in Cellular Neuroscience. 7: 226. PMID 24324400 DOI: 10.3389/Fncel.2013.00226  0.447
2013 Daou I, Tuttle AH, Longo G, Wieskopf JS, Bonin RP, Ase AR, Wood JN, De Koninck Y, Ribeiro-da-Silva A, Mogil JS, Séguéla P. Remote optogenetic activation and sensitization of pain pathways in freely moving mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18631-40. PMID 24259584 DOI: 10.1523/Jneurosci.2424-13.2013  0.438
2013 Bernier LP, Ase AR, Boué-Grabot É, Séguéla P. Inhibition of P2X4 function by P2Y6 UDP receptors in microglia. Glia. 61: 2038-49. PMID 24123515 DOI: 10.1002/Glia.22574  0.452
2013 Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A, Séguéla P. Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors. Plos One. 8: e66122. PMID 23785477 DOI: 10.1371/journal.pone.0066122  0.398
2013 Mo G, Peleshok JC, Cao CQ, Ribeiro-da-Silva A, Séguéla P. Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons. Molecular Pharmacology. 83: 640-7. PMID 23249537 DOI: 10.1124/Mol.112.082099  0.668
2012 Serrano A, Mo G, Grant R, Paré M, O'Donnell D, Yu XH, Tomaszewski MJ, Perkins MN, Séguéla P, Cao CQ. Differential expression and pharmacology of native P2X receptors in rat and primate sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11890-6. PMID 22915129 DOI: 10.1523/JNEUROSCI.0698-12.2012  0.638
2012 Bernier LP, Blais D, Boué-Grabot É, Séguéla P. A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family. Plos One. 7: e40595. PMID 22792379 DOI: 10.1371/journal.pone.0040595  0.354
2012 Bernier LP, Ase AR, Boué-Grabot E, Séguéla P. P2X4 receptor channels form large noncytolytic pores in resting and activated microglia. Glia. 60: 728-37. PMID 22318986 DOI: 10.1002/Glia.22301  0.449
2011 Mo G, Grant R, O'Donnell D, Ragsdale DS, Cao CQ, Séguéla P. Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C. Molecular Pain. 7: 14. PMID 21314936 DOI: 10.1186/1744-8069-7-14  0.643
2011 Zimmerman B, Simaan M, Akoume MY, Houri N, Chevallier S, Séguéla P, Laporte SA. Role of ßarrestins in bradykinin B2 receptor-mediated signalling. Cellular Signalling. 23: 648-59. PMID 21145390 DOI: 10.1016/j.cellsig.2010.11.016  0.365
2011 Zhang Z, Reboreda A, Alonso A, Barker PA, Séguéla P. TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex. Hippocampus. 21: 386-97. PMID 20082292 DOI: 10.1002/Hipo.20755  0.411
2010 Ase AR, Bernier LP, Blais D, Pankratov Y, Séguéla P. Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit. Journal of Neurochemistry. 113: 1676-84. PMID 20374427 DOI: 10.1111/J.1471-4159.2010.06734.X  0.439
2010 Zhang Z, Séguéla P. Metabotropic induction of persistent activity in layers II/III of anterior cingulate cortex. Cerebral Cortex (New York, N.Y. : 1991). 20: 2948-57. PMID 20348157 DOI: 10.1093/cercor/bhq043  0.441
2009 Mo G, Bernier LP, Zhao Q, Chabot-Doré AJ, Ase AR, Logothetis D, Cao CQ, Séguéla P. Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors. Molecular Pain. 5: 47. PMID 19671169 DOI: 10.1186/1744-8069-5-47  0.661
2009 Curia G, Papouin T, Séguéla P, Avoli M. Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome. Cerebral Cortex (New York, N.Y. : 1991). 19: 1515-20. PMID 18787232 DOI: 10.1093/Cercor/Bhn159  0.316
2008 Bernier LP, Ase AR, Chevallier S, Blais D, Zhao Q, Boué-Grabot E, Logothetis D, Séguéla P. Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12938-45. PMID 19036987 DOI: 10.1523/Jneurosci.3038-08.2008  0.435
2008 Bernier LP, Ase AR, Tong X, Hamel E, Blais D, Zhao Q, Logothetis DE, Séguéla P. Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate. Molecular Pharmacology. 74: 785-92. PMID 18523136 DOI: 10.1124/Mol.108.047019  0.393
2007 Raouf R, Chabot-Doré AJ, Ase AR, Blais D, Séguéla P. Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation. Neuropharmacology. 53: 496-504. PMID 17675190 DOI: 10.1016/J.Neuropharm.2007.06.010  0.396
2007 Joch M, Ase AR, Chen CX, MacDonald PA, Kontogiannea M, Corera AT, Brice A, Séguéla P, Fon EA. Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Molecular Biology of the Cell. 18: 3105-18. PMID 17553932 DOI: 10.1091/Mbc.E05-11-1027  0.37
2007 Toulmé E, Blais D, Léger C, Landry M, Garret M, Séguéla P, Boué-Grabot E. An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons. Journal of Neurochemistry. 102: 1357-68. PMID 17498217 DOI: 10.1111/J.1471-4159.2007.04640.X  0.401
2007 Zhao Q, Logothetis DE, Séguéla P. Regulation of ATP-gated P2X receptors by phosphoinositides. PflüGers Archiv : European Journal of Physiology. 455: 181-5. PMID 17479282 DOI: 10.1007/S00424-007-0271-X  0.4
2007 Reboreda A, Raouf R, Alonso A, Séguéla P. Development of cholinergic modulation and graded persistent activity in layer v of medial entorhinal cortex. Journal of Neurophysiology. 97: 3937-47. PMID 17442765 DOI: 10.1152/jn.01233.2006  0.371
2006 Sharif Naeini R, Witty MF, Séguéla P, Bourque CW. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nature Neuroscience. 9: 93-8. PMID 16327782 DOI: 10.1038/Nn1614  0.438
2005 Mogil JS, Breese NM, Witty MF, Ritchie J, Rainville ML, Ase A, Abbadi N, Stucky CL, Séguéla P. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9893-901. PMID 16251436 DOI: 10.1523/Jneurosci.2019-05.2005  0.439
2005 Ase AR, Raouf R, Bélanger D, Hamel E, Séguéla P. Potentiation of P2X1 ATP-gated currents by 5-hydroxytryptamine 2A receptors involves diacylglycerol-dependent kinases and intracellular calcium. The Journal of Pharmacology and Experimental Therapeutics. 315: 144-54. PMID 15958718 DOI: 10.1124/Jpet.105.089045  0.34
2005 Raouf R, Blais D, Séguéla P. High zinc sensitivity and pore formation in an invertebrate P2X receptor. Biochimica Et Biophysica Acta. 1669: 135-41. PMID 15893516 DOI: 10.1016/j.bbamem.2005.01.009  0.387
2004 Raouf R, Chakfe Y, Blais D, Speelman A, Boué-Grabot E, Henderson D, Séguéla P. Selective knock-down of P2X7 ATP receptor function by dominant-negative subunits. Molecular Pharmacology. 65: 646-54. PMID 14978243 DOI: 10.1124/mol.65.3.646  0.387
2004 Boué-Grabot E, Emerit MB, Toulmé E, Séguéla P, Garret M. Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. The Journal of Biological Chemistry. 279: 6967-75. PMID 14660627 DOI: 10.1074/jbc.M307772200  0.42
2003 Tsuzuki K, Ase A, Séguéla P, Nakatsuka T, Wang CY, She JX, Gu JG. TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons. Journal of Neurophysiology. 89: 3235-42. PMID 12783957 DOI: 10.1152/Jn.01171.2002  0.404
2003 Boué-Grabot E, Barajas-López C, Chakfe Y, Blais D, Bélanger D, Emerit MB, Séguéla P. Intracellular cross talk and physical interaction between two classes of neurotransmitter-gated channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1246-53. PMID 12598613 DOI: 10.1523/Jneurosci.23-04-01246.2003  0.424
2002 Chakfe Y, Seguin R, Antel JP, Morissette C, Malo D, Henderson D, Séguéla P. ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3061-9. PMID 11943809 DOI: 10.1523/Jneurosci.22-08-03061.2002  0.349
2001 Catarsi S, Babinski K, Séguéla P. Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF. Neuropharmacology. 41: 592-600. PMID 11587714 DOI: 10.1016/S0028-3908(01)00107-1  0.427
2001 Biagini G, Babinski K, Avoli M, Marcinkiewicz M, Séguéla P. Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy. Neurobiology of Disease. 8: 45-58. PMID 11162239 DOI: 10.1006/Nbdi.2000.0331  0.415
2000 Boué-Grabot E, Akimenko MA, Séguéla P. Unique functional properties of a sensory neuronal P2X ATP-gated channel from zebrafish. Journal of Neurochemistry. 75: 1600-7. PMID 10987841 DOI: 10.1046/J.1471-4159.2000.0751600.X  0.44
2000 Babinski K, Catarsi S, Biagini G, Séguéla P. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. The Journal of Biological Chemistry. 275: 28519-25. PMID 10842183 DOI: 10.1074/Jbc.M004114200  0.413
2000 Boué-Grabot E, Archambault V, Séguéla P. A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X(2) ATP-gated channels. The Journal of Biological Chemistry. 275: 10190-5. PMID 10744703 DOI: 10.1074/Jbc.275.14.10190  0.375
1999 Lê KT, Boué-Grabot E, Archambault V, Séguéla P. Functional and biochemical evidence for heteromeric ATP-gated channels composed of P2X1 and P2X5 subunits. The Journal of Biological Chemistry. 274: 15415-9. PMID 10336430 DOI: 10.1074/Jbc.274.22.15415  0.422
1999 Babinski K, Lê KT, Séguéla P. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. Journal of Neurochemistry. 72: 51-7. PMID 9886053 DOI: 10.1046/J.1471-4159.1999.0720051.X  0.403
1998 Lê KT, Babinski K, Séguéla P. Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7152-9. PMID 9736638 DOI: 10.1523/Jneurosci.18-18-07152.1998  0.417
1998 Lê KT, Villeneuve P, Ramjaun AR, McPherson PS, Beaudet A, Séguéla P. Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors. Neuroscience. 83: 177-90. PMID 9466408 DOI: 10.1016/S0306-4522(97)00365-5  0.409
1997 Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. Febs Letters. 418: 195-9. PMID 9414125 DOI: 10.1016/S0014-5793(97)01380-X  0.366
1997 Botto JM, Chabry J, Nouel D, Paquet M, Séguéla P, Vincent JP, Beaudet A, Mazella J. Identification in the rat neurotensin receptor of amino-acid residues critical for the binding of neurotensin. Brain Research. Molecular Brain Research. 46: 311-7. PMID 9191107 DOI: 10.1016/S0169-328X(97)00006-5  0.331
1996 Mukerji J, Haghighi A, Séguéla P. Immunological characterization and transmembrane topology of 5-hydroxytryptamine3 receptors by functional epitope tagging. Journal of Neurochemistry. 66: 1027-32. PMID 8769863 DOI: 10.1046/J.1471-4159.1996.66031027.X  0.392
1996 Séguéla P, Haghighi A, Soghomonian JJ, Cooper E. A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 448-55. PMID 8551329 DOI: 10.1523/Jneurosci.16-02-00448.1996  0.432
1993 Séguéla P, Wadiche J, Dineley-Miller K, Dani JA, Patrick JW. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 596-604. PMID 7678857 DOI: 10.1523/Jneurosci.13-02-00596.1993  0.332
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