Pamela Tannenbaum - Publications

Affiliations: 
Merck Neuroscience, New Brunswick, NJ, United States 
Area:
Behavioral Neuroendocrinology

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Gotter AL, Forman MS, Harrell CM, Stevens J, Svetnik V, Yee KL, Li X, Roecker AJ, Fox SV, Tannenbaum PL, Garson SL, Lepeleire ID, Calder N, Rosen L, Struyk A, et al. Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man. Scientific Reports. 6: 27147. PMID 27256922 DOI: 10.1038/srep27147  0.76
2015 Kuduk SD, Skudlarek JW, DiMarco CN, Bruno JG, Pausch MH, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Garson SL, Savitz AT, Harrell CM, Gotter AL, Winrow CJ, et al. Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties. Bioorganic & Medicinal Chemistry Letters. 25: 2488-92. PMID 25981685 DOI: 10.1016/j.bmcl.2015.04.066  0.76
2015 Roecker AJ, Mercer SP, Bergman JM, Gilbert KF, Kuduk SD, Harrell CM, Garson SL, Fox SV, Gotter AL, Tannenbaum PL, Prueksaritanont T, Cabalu TD, Cui D, Lemaire W, Winrow CJ, et al. Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements. Bioorganic & Medicinal Chemistry Letters. PMID 25613676 DOI: 10.1016/j.bmcl.2014.12.081  0.76
2015 Raheem IT, Breslin MJ, Bruno J, Cabalu TD, Cooke A, Cox CD, Cui D, Garson S, Gotter AL, Fox SV, Harrell CM, Kuduk SD, Lemaire W, Prueksaritanont T, Renger JJ, ... ... Tannenbaum PL, et al. Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. Bioorganic & Medicinal Chemistry Letters. 25: 444-50. PMID 25577040 DOI: 10.1016/j.bmcl.2014.12.056  0.76
2014 Roecker AJ, Reger TS, Mattern MC, Mercer SP, Bergman JM, Schreier JD, Cube RV, Cox CD, Li D, Lemaire W, Bruno JG, Harrell CM, Garson SL, Gotter AL, Fox SV, ... ... Tannenbaum PL, et al. Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Bioorganic & Medicinal Chemistry Letters. 24: 4884-90. PMID 25248679 DOI: 10.1016/j.bmcl.2014.08.041  0.76
2014 Gotter AL, Garson SL, Stevens J, Munden RL, Fox SV, Tannenbaum PL, Yao L, Kuduk SD, McDonald T, Uslaner JM, Tye SJ, Coleman PJ, Winrow CJ, Renger JJ. Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators. Bmc Neuroscience. 15: 109. PMID 25242351 DOI: 10.1186/1471-2202-15-109  0.76
2014 Tannenbaum PL, Stevens J, Binns J, Savitz AT, Garson SL, Fox SV, Coleman P, Kuduk SD, Gotter AL, Marino M, Tye SJ, Uslaner JM, Winrow CJ, Renger JJ. Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs. Frontiers in Behavioral Neuroscience. 8: 182. PMID 24904334 DOI: 10.3389/fnbeh.2014.00182  0.76
2014 Kuduk SD, Skudlarek JW, Di Marco CN, Bruno JG, Pausch MA, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Gotter AL, Winrow CJ, Renger JJ, Coleman PJ. Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant. Bioorganic & Medicinal Chemistry Letters. 24: 1784-9. PMID 24630562 DOI: 10.1016/j.bmcl.2014.02.026  0.76
2014 Roecker AJ, Mercer SP, Schreier JD, Cox CD, Fraley ME, Steen JT, Lemaire W, Bruno JG, Harrell CM, Garson SL, Gotter AL, Fox SV, Stevens J, Tannenbaum PL, Prueksaritanont T, et al. Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Chemmedchem. 9: 311-22. PMID 24376006 DOI: 10.1002/cmdc.201300447  0.76
2013 Ramirez AD, Gotter AL, Fox SV, Tannenbaum PL, Yao L, Tye SJ, McDonald T, Brunner J, Garson SL, Reiss DR, Kuduk SD, Coleman PJ, Uslaner JM, Hodgson R, Browne SE, et al. Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators. Frontiers in Neuroscience. 7: 254. PMID 24399926 DOI: 10.3389/fnins.2013.00254  0.76
2013 Gotter AL, Winrow CJ, Brunner J, Garson SL, Fox SV, Binns J, Harrell CM, Cui D, Yee KL, Stiteler M, Stevens J, Savitz A, Tannenbaum PL, Tye SJ, McDonald T, et al. The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold. Bmc Neuroscience. 14: 90. PMID 23981345 DOI: 10.1186/1471-2202-14-90  0.76
2013 Fox SV, Gotter AL, Tye SJ, Garson SL, Savitz AT, Uslaner JM, Brunner JI, Tannenbaum PL, McDonald TP, Hodgson R, Yao L, Bowlby MR, Kuduk SD, Coleman PJ, Hargreaves R, et al. Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2401-8. PMID 23722242 DOI: 10.1038/npp.2013.139  0.76
2013 Uslaner JM, Tye SJ, Eddins DM, Wang X, Fox SV, Savitz AT, Binns J, Cannon CE, Garson SL, Yao L, Hodgson R, Stevens J, Bowlby MR, Tannenbaum PL, Brunner J, et al. Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition. Science Translational Medicine. 5: 179ra44. PMID 23552372 DOI: 10.1126/scitranslmed.3005213  0.76
2013 Zhang X, Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, Bhattacharjee S, Lundeen SG, Sui Z. Pharmacological characterization of an imidazolopyrazole as novel selective androgen receptor modulator. The Journal of Steroid Biochemistry and Molecular Biology. 134: 51-8. PMID 23098693 DOI: 10.1016/j.jsbmb.2012.10.015  0.76
2012 Coleman PJ, Schreier JD, Cox CD, Breslin MJ, Whitman DB, Bogusky MJ, McGaughey GB, Bednar RA, Lemaire W, Doran SM, Fox SV, Garson SL, Gotter AL, Harrell CM, Reiss DR, ... ... Tannenbaum PL, et al. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. Chemmedchem. 7: 415-24, 337. PMID 22307992 DOI: 10.1002/cmdc.201200025  0.76
2012 Winrow CJ, Gotter AL, Cox CD, Tannenbaum PL, Garson SL, Doran SM, Breslin MJ, Schreier JD, Fox SV, Harrell CM, Stevens J, Reiss DR, Cui D, Coleman PJ, Renger JJ. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 62: 978-87. PMID 22019562 DOI: 10.1016/j.neuropharm.2011.10.003  0.76
2012 Coburn CA, Luo Y, Cui M, Wang J, Soll R, Dong J, Hu B, Lyon MA, Santarelli VP, Kraus RL, Gregan Y, Wang Y, Fox SV, Binns J, Doran SM, ... ... Tannenbaum PL, et al. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). Chemmedchem. 7: 123-33. PMID 21916012 DOI: 10.1002/cmdc.201100351  0.76
2011 Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K, McCampbell A, Stevens J, Brunner JI, Fox SV, Uebele VN, et al. TASK-3 as a potential antidepressant target. Brain Research. 1416: 69-79. PMID 21885038 DOI: 10.1016/j.brainres.2011.08.021  0.76
2011 Winrow CJ, Gotter AL, Cox CD, Doran SM, Tannenbaum PL, Breslin MJ, Garson SL, Fox SV, Harrell CM, Stevens J, Reiss DR, Cui D, Coleman PJ, Renger JJ. Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist. Journal of Neurogenetics. 25: 52-61. PMID 21473737 DOI: 10.3109/01677063.2011.566953  0.76
2011 Snowdon CT, Tannenbaum PL, Schultz-Darken NJ, Ziegler TE, Ferris CF. Conditioned sexual arousal in a nonhuman primate. Hormones and Behavior. 59: 696-701. PMID 21029736 DOI: 10.1016/j.yhbeh.2010.10.009  0.76
2010 Woller MJ, Tannenbaum PL, Schultz-Darken NJ, Eshelman BD, Abbott DH. Pulsatile gonadotropin-releasing hormone release from hypothalamic explants of male marmoset monkeys compared with male rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298: R70-8. PMID 19889867 DOI: 10.1152/ajpregu.00193.2009  0.76
2009 Jain N, Allan G, Linton O, Tannenbaum P, Chen X, Xu J, Zhu P, Gunnet J, Demarest K, Lundeen S, Murray W, Sui Z. Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 3977-80. PMID 19217285 DOI: 10.1016/j.bmcl.2009.01.095  0.76
2009 Lynch J, Regan C, Stump G, Tannenbaum P, Stevens J, Bone A, Gilberto D, Johnson C, Fujino N, Takenaga N, Tokita S, Nagase T, Sato N, Renger J. Hemodynamic and cardiac neurotransmitter-releasing effects in conscious dogs of attention- and wake-promoting agents: a comparison of d-amphetamine, atomoxetine, modafinil, and a novel quinazolinone H3 inverse agonist. Journal of Cardiovascular Pharmacology. 53: 52-9. PMID 19129736 DOI: 10.1097/FJC.0b013e318195a470  0.76
2008 Kang FA, Chen X, Jain N, Allan G, Tannenbaum P, Lundeen S, Sui Z. Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids. Bioorganic & Medicinal Chemistry Letters. 18: 3687-90. PMID 18539027 DOI: 10.1016/j.bmcl.2008.05.070  0.76
2007 Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, Bhattacharjee S, Zhang X, Sui Z, Lundeen SG. A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats. Endocrine. 32: 41-51. PMID 17992601 DOI: 10.1007/s12020-007-9005-2  0.76
2007 Tannenbaum PL, Schultz-Darken NJ, Woller MJ, Abbott DH. Gonadotrophin-releasing hormone (GnRH) release in marmosets II: pulsatile release of GnRH and pituitary gonadotrophin in adult females. Journal of Neuroendocrinology. 19: 354-63. PMID 17425610 DOI: 10.1111/j.1365-2826.2007.01535.x  0.76
2007 Tannenbaum PL, Schultz-Darken NJ, Saltzman W, Terasawa E, Woller MJ, Abbott DH. Gonadotrophin-releasing hormone (GnRH) release in marmosets I: in vivo measurement in ovary-intact and ovariectomised females. Journal of Neuroendocrinology. 19: 342-53. PMID 17425609 DOI: 10.1111/j.1365-2826.2007.01534.x  0.76
2007 Kang FA, Guan J, Jain N, Allan G, Linton O, Tannenbaum P, Chen X, Xu J, Zhu P, Gunnet J, Demarest K, Lundeen S, Sui Z. Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 2531-4. PMID 17317167 DOI: 10.1016/j.bmcl.2007.02.013  0.76
2007 Jiang W, Fiordeliso JJ, Allan G, Linton O, Tannenbaum P, Xu J, Zhu P, Gunnet J, Demarest K, Lundeen S, Sui Z. Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 17: 1471-4. PMID 17258455 DOI: 10.1016/j.bmcl.2006.10.003  0.76
2007 Kang FA, Allan G, Guan J, Jain N, Linton O, Tannenbaum P, Xu J, Zhu P, Gunnet J, Chen X, Demarest K, Lundeen S, Sui Z. Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 907-10. PMID 17169557 DOI: 10.1016/j.bmcl.2006.11.062  0.76
2006 Jiang W, Allan G, Chen X, Fiordeliso JJ, Linton O, Tannenbaum P, Xu J, Zhu P, Gunnet J, Demarest K, Lundeen S, Sui Z. Novel phosphorus-containing 17beta-side chain mifepristone analogues as progesterone receptor antagonists. Steroids. 71: 949-54. PMID 16934845 DOI: 10.1016/j.steroids.2006.07.003  0.76
2006 Jiang W, Allan G, Fiordeliso JJ, Linton O, Tannenbaum P, Xu J, Zhu P, Gunnet J, Demarest K, Lundeen S, Sui Z. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorganic & Medicinal Chemistry. 14: 6726-32. PMID 16806946 DOI: 10.1016/j.bmc.2006.05.066  0.76
2004 Schultz-Darken NJ, Pape RM, Tannenbaum PL, Saltzman W, Abbott DH. Novel restraint system for neuroendocrine studies of socially living common marmoset monkeys. Laboratory Animals. 38: 393-405. PMID 15479554 DOI: 10.1258/0023677041958918  0.76
2004 Ferris CF, Snowdon CT, King JA, Sullivan JM, Ziegler TE, Olson DP, Schultz-Darken NJ, Tannenbaum PL, Ludwig R, Wu Z, Einspanier A, Vaughan JT, Duong TQ. Activation of neural pathways associated with sexual arousal in non-human primates. Journal of Magnetic Resonance Imaging : Jmri. 19: 168-75. PMID 14745749 DOI: 10.1002/jmri.10456  0.76
2002 Riley RC, Tannenbaum PL, Abbott DH, Atkinson JP. Cutting edge: inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46. Journal of Immunology (Baltimore, Md. : 1950). 169: 5405-9. PMID 12421914  0.76
2001 Ferris CF, Snowdon CT, King JA, Duong TQ, Ziegler TE, Ugurbil K, Ludwig R, Schultz-Darken NJ, Wu Z, Olson DP, Sullivan Jr JM, Tannenbaum PL, Vaughan JT. Functional imaging of brain activity in conscious monkeys responding to sexually arousing cues. Neuroreport. 12: 2231-6. PMID 11447340  0.76
2000 Zehr JL, Tannenbaum PL, Jones B, Wallen K. Peak occurrence of female sexual initiation predicts day of conception in rhesus monkeys (Macaca mulatta). Reproduction, Fertility, and Development. 12: 397-404. PMID 11545179  0.76
1998 Abbott DH, Saltzman W, Schultz-Darken NJ, Tannenbaum PL. Adaptations to subordinate status in female marmoset monkeys. Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 119: 261-74. PMID 9826999 DOI: 10.1016/S0742-8413(98)00015-2  0.76
1997 Tannenbaum PL, Wallen K. Sexually initiated affiliation facilitates rhesus monkey integration. Annals of the New York Academy of Sciences. 807: 578-82. PMID 9071403 DOI: 10.1111/j.1749-6632.1997.tb51973.x  0.76
1997 Wallen K, Tannenbaum PL. Hormonal modulation of sexual behavior and affiliation in rhesus monkeys. Annals of the New York Academy of Sciences. 807: 185-202. PMID 9071351 DOI: 10.1111/j.1749-6632.1997.tb51920.x  0.76
1993 Eisler JA, Tannenbaum PL, Mann DR, Wallen K. Neonatal testicular suppression with a GnRH agonist in rhesus monkeys: effects on adult endocrine function and behavior. Hormones and Behavior. 27: 551-67. PMID 8294122 DOI: 10.1006/hbeh.1993.1040  0.76
1991 Wallen K, Eisler JA, Tannenbaum PL, Nagell KM, Mann DR. Antide (Nal-Lys GnRH antagonist) suppression of pituitary-testicular function and sexual behavior in group-living rhesus monkeys. Physiology & Behavior. 50: 429-35. PMID 1745690 DOI: 10.1016/0031-9384(91)90090-B  0.76
1991 Elowson AM, Tannenbaum PL, Snowdon CT. Food-associated calls correlate with food preferences in cotton-top tamarins Animal Behaviour. 42: 931-937. DOI: 10.1016/S0003-3472(05)80145-9  0.76
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