Ryan Jefferson Watts - Publications

Affiliations: 
Genentech, San Francisco, CA, United States 
Area:
Neurodegeneration, Blood-brian barrier

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, ... ... Watts RJ, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation. PMID 29600961 DOI: 10.1172/JCI96429  1
2016 Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, ... ... Watts RJ, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports. PMID 27475227 DOI: 10.1016/j.celrep.2016.06.099  1
2016 Lu Y, Hoyte K, Montgomery WH, Luk W, He D, Meilandt WJ, Yu Zuchero YJ, Atwal JK, Scearce-Levie K, Watts RJ, DeForge LE. Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice. Bioanalysis. PMID 27094761 DOI: 10.4155/bio-2016-0003  1
2016 Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S. Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 26820920 DOI: 10.1016/j.ejpb.2016.01.009  1
2015 Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, ... ... Watts RJ, et al. Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron. PMID 26687840 DOI: 10.1016/j.neuron.2015.11.024  1
2015 Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ. Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88: 289-97. PMID 26494278 DOI: 10.1016/j.neuron.2015.09.036  1
2015 Fuji RN, Flagella M, Baca M, Baptista MA, Brodbeck J, Chan BK, Fiske BK, Honigberg L, Jubb AM, Katavolos P, Lee DW, Lewin-Koh SC, Lin T, Liu X, Liu S, ... ... Watts RJ, et al. Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Science Translational Medicine. 7: 273ra15. PMID 25653221 DOI: 10.1126/scitranslmed.aaa3634  1
2014 Watts RJ. Sleeping our Alzheimer's risk away. The Journal of Experimental Medicine. 211: 2484-5. PMID 25512582 DOI: 10.1084/jem.21113insight4  1
2014 Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, ... ... Watts RJ, et al. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature Medicine. 20: 1452-7. PMID 25419706 DOI: 10.1038/nm.3736  1
2014 Huntley MA, Bien-Ly N, Daneman R, Watts RJ. Dissecting gene expression at the blood-brain barrier. Frontiers in Neuroscience. 8: 355. PMID 25414634 DOI: 10.3389/fnins.2014.00355  1
2014 Thomas AA, Hunt KW, Newhouse B, Watts RJ, Liu X, Vigers G, Smith D, Rhodes SP, Brown KD, Otten JN, Burkard M, Cox AA, Geck Do MK, Dutcher D, Rana S, et al. 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors. Journal of Medicinal Chemistry. 57: 10112-29. PMID 25411915 DOI: 10.1021/jm5015132  1
2014 Bien-Ly N, Watts RJ. The blood-brain barrier's gut check. Science Translational Medicine. 6: 263fs46. PMID 25411469 DOI: 10.1126/scitranslmed.aaa2543  1
2014 Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, ... ... Watts RJ, et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154. PMID 25378646 DOI: 10.1126/scitranslmed.3009835  1
2014 Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, van der Brug M, Liu Y, Ernst JA, Watts RJ, Atwal JK. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. The Journal of Biological Chemistry. 289: 30990-1000. PMID 25253696 DOI: 10.1074/jbc.M114.589069  1
2014 Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44. PMID 24470444 DOI: 10.1084/jem.20131660  1
2014 Thomas AA, Hunt KW, Volgraf M, Watts RJ, Liu X, Vigers G, Smith D, Sammond D, Tang TP, Rhodes SP, Metcalf AT, Brown KD, Otten JN, Burkard M, Cox AA, et al. Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system. Journal of Medicinal Chemistry. 57: 878-902. PMID 24397738 DOI: 10.1021/jm401635n  1
2014 Shin YG, Hamm L, Murakami S, Buirst K, Buonarati MH, Cox A, Regal K, Hunt KW, Scearce-Levie K, Watts RJ, Liu X. Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction. Archives of Pharmacal Research. 37: 636-44. PMID 23888333 DOI: 10.1007/s12272-013-0215-2  1
2013 Le Pichon CE, Dominguez SL, Solanoy H, Ngu H, Lewin-Koh N, Chen M, Eastham-Anderson J, Watts R, Scearce-Levie K. EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS. Plos One. 8: e62342. PMID 23638043 DOI: 10.1371/journal.pone.0062342  1
2013 Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, ... ... Watts RJ, et al. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier. Science Translational Medicine. 5: 183ra57, 1-12. PMID 23636093 DOI: 10.1126/scitranslmed.3005338  1
2013 Liu X, Wong H, Scearce-Levie K, Watts RJ, Coraggio M, Shin YG, Peng K, Wildsmith KR, Atwal JK, Mango J, Schauer SP, Regal K, Hunt KW, Thomas AA, Siu M, et al. Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1319-28. PMID 23584887 DOI: 10.1124/dmd.112.050864  1
2013 Watts RJ, Dennis MS. Bispecific antibodies for delivery into the brain. Current Opinion in Chemical Biology. 17: 393-9. PMID 23570979 DOI: 10.1016/j.cbpa.2013.03.023  1
2013 Yu YJ, Watts RJ. Developing therapeutic antibodies for neurodegenerative disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 459-72. PMID 23549647 DOI: 10.1007/s13311-013-0187-4  1
2013 Hunt KW, Cook AW, Watts RJ, Clark CT, Vigers G, Smith D, Metcalf AT, Gunawardana IW, Burkard M, Cox AA, Geck Do MK, Dutcher D, Thomas AA, Rana S, Kallan NC, et al. Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species. Journal of Medicinal Chemistry. 56: 3379-403. PMID 23537249 DOI: 10.1021/jm4002154  1
2012 Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ. Spatially coordinated kinase signaling regulates local axon degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13439-53. PMID 23015435 DOI: 10.1523/JNEUROSCI.2039-12.2012  1
2012 Xin Y, Li J, Wu J, Kinard R, Weekes CD, Patnaik A, Lorusso P, Brachmann R, Tong RK, Yan Y, Watts R, Bai S, Hegde PS. Pharmacokinetic and pharmacodynamic analysis of circulating biomarkers of anti-NRP1, a novel antiangiogenesis agent, in two phase I trials in patients with advanced solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6040-8. PMID 22962439 DOI: 10.1158/1078-0432.CCR-12-1652  1
2012 Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, ... ... Watts RJ, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. 488: 96-9. PMID 22801501 DOI: 10.1038/nature11283  1
2012 Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, ... ... Watts RJ, et al. An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9677-89. PMID 22787053 DOI: 10.1523/JNEUROSCI.4742-11.2012  1
2012 Tam SJ, Richmond DL, Kaminker JS, Modrusan Z, Martin-McNulty B, Cao TC, Weimer RM, Carano RA, van Bruggen N, Watts RJ. Death receptors DR6 and TROY regulate brain vascular development. Developmental Cell. 22: 403-17. PMID 22340501 DOI: 10.1016/j.devcel.2011.11.018  1
2012 Dennis MS, Watts RJ. Transferrin antibodies into the brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 302-3. PMID 22157868 DOI: 10.1038/npp.2011.196  1
2011 Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. The Journal of Cell Biology. 194: 751-64. PMID 21893599 DOI: 10.1083/jcb.201103153  1
2011 Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Science Translational Medicine. 3: 84ra44. PMID 21613623 DOI: 10.1126/scitranslmed.3002230  1
2011 Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, ... ... Watts RJ, et al. A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Science Translational Medicine. 3: 84ra43. PMID 21613622 DOI: 10.1126/scitranslmed.3002254  1
2011 Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR. Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews. Neuroscience. 12: 169-82. PMID 21331083 DOI: 10.1038/nrn2995  1
2011 Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, ... ... Watts RJ, et al. Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Developmental Cell. 20: 33-46. PMID 21238923 DOI: 10.1016/j.devcel.2010.12.001  1
2010 Duxbury K, Romagnoli C, Anderson M, Watts R, Waite G. Development of a clinically relevant liquid chromatography tandem mass spectrometry assay for 13 drugs of abuse in urine, designed to meet the needs of the service users Annals of Clinical Biochemistry. 47: 415-422. PMID 20595401 DOI: 10.1258/acb.2010.010049  1
2010 Cao S, Yaqoob U, Das A, Shergill U, Jagavelu K, Huebert RC, Routray C, Abdelmoneim S, Vasdev M, Leof E, Charlton M, Watts RJ, Mukhopadhyay D, Shah VH. Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells. The Journal of Clinical Investigation. 120: 2379-94. PMID 20577048 DOI: 10.1172/JCI41203  1
2010 Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 464: 1052-7. PMID 20393564 DOI: 10.1038/nature08878  1
2010 Tam SJ, Watts RJ. Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. Annual Review of Neuroscience. 33: 379-408. PMID 20367445 DOI: 10.1146/annurev-neuro-060909-152829  1
2009 Lu Y, Xiang H, Liu P, Tong RR, Watts RJ, Koch AW, Sandoval WN, Damico LA, Wong WL, Meng YG. Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration. Mabs. 1: 364-9. PMID 20068394  1
2009 Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, ... ... Watts RJ, et al. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 6152-7. PMID 19369214 DOI: 10.1073/pnas.0813061106  1
2009 Bagri A, Tessier-Lavigne M, Watts RJ. Neuropilins in tumor biology. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1860-4. PMID 19240167 DOI: 10.1158/1078-0432.CCR-08-0563  1
2008 Hoopfer ED, Penton A, Watts RJ, Luo L. Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6092-103. PMID 18550751 DOI: 10.1523/JNEUROSCI.0677-08.2008  1
2008 Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A. Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development (Cambridge, England). 135: 2479-88. PMID 18550715 DOI: 10.1242/dev.014902  1
2008 Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, Tong RK, Kowalski J, Ho C, Reslan HB, Ross J, Berry L, Kasman I, Zlot C, Cheng Z, Le Couter J, ... ... Watts RJ, et al. Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell. 13: 331-42. PMID 18394556 DOI: 10.1016/j.ccr.2008.01.029  1
2007 Appleton BA, Wu P, Maloney J, Yin J, Liang WC, Stawicki S, Mortara K, Bowman KK, Elliott JM, Desmarais W, Bazan JF, Bagri A, Tessier-Lavigne M, Koch AW, Wu Y, ... Watts RJ, et al. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. The Embo Journal. 26: 4902-12. PMID 17989695 DOI: 10.1038/sj.emboj.7601906  1
2007 Pan Q, Chathery Y, Wu Y, Rathore N, Tong RK, Peale F, Bagri A, Tessier-Lavigne M, Koch AW, Watts RJ. Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. The Journal of Biological Chemistry. 282: 24049-56. PMID 17575273 DOI: 10.1074/jbc.M703554200  1
2007 Pan Q, Chanthery Y, Liang WC, Stawicki S, Mak J, Rathore N, Tong RK, Kowalski J, Yee SF, Pacheco G, Ross S, Cheng Z, Le Couter J, Plowman G, Peale F, ... ... Watts RJ, et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell. 11: 53-67. PMID 17222790 DOI: 10.1016/j.ccr.2006.10.018  1
2007 Liang WC, Dennis MS, Stawicki S, Chanthery Y, Pan Q, Chen Y, Eigenbrot C, Yin J, Koch AW, Wu X, Ferrara N, Bagri A, Tessier-Lavigne M, Watts RJ, Wu Y. Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. Journal of Molecular Biology. 366: 815-29. PMID 17196977 DOI: 10.1016/j.jmb.2006.11.021  1
2006 Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y, Kowalski J, Watts RJ, Callahan C, Kasman I, Singh M, Chien M, Tan C, Hongo JA, de Sauvage F, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature. 444: 1083-7. PMID 17183323 DOI: 10.1038/nature05313  1
2006 Hoopfer ED, McLaughlin T, Watts RJ, Schuldiner O, O'Leary DD, Luo L. Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron. 50: 883-95. PMID 16772170 DOI: 10.1016/j.neuron.2006.05.013  1
2006 MacDonald JM, Beach MG, Porpiglia E, Sheehan AE, Watts RJ, Freeman MR. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron. 50: 869-81. PMID 16772169 DOI: 10.1016/j.neuron.2006.04.028  1
2005 Marin EC, Watts RJ, Tanaka NK, Ito K, Luo L. Developmentally programmed remodeling of the Drosophila olfactory circuit. Development (Cambridge, England). 132: 725-37. PMID 15659487 DOI: 10.1242/dev.01614  1
2004 Watts RJ, Schuldiner O, Perrino J, Larsen C, Luo L. Glia engulf degenerating axons during developmental axon pruning. Current Biology : Cb. 14: 678-84. PMID 15084282 DOI: 10.1016/j.cub.2004.03.035  1
2003 Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 39: 217-25. PMID 12873380 DOI: 10.1016/S0896-6273(03)00429-X  1
2003 Watts RJ, Hoopfer ED, Luo L. Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron. 38: 871-85. PMID 12818174 DOI: 10.1016/S0896-6273(03)00295-2  1
2002 Jefferis GS, Marin EC, Watts RJ, Luo L. Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies. Current Opinion in Neurobiology. 12: 80-6. PMID 11861168 DOI: 10.1016/S0959-4388(02)00293-3  1
1988 Ghazarossian V, Laney M, Vorpahl J, Pease J, Skold C, Watts R, Jeong H, Dafforn A, Cook R, Ullman EF. A non-flow cytometric system for detecting antibodies and cellular antigens in blood Clinical Chemistry. 34: 1720-1725. PMID 3138038  1
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