| Year |
Citation |
Score |
| 2023 |
Rahman SMT, Zhou W, Deiters A, Haugh JM. Dissection of MKK6 and p38 Signaling Using Light-Activated Protein Kinases. Chembiochem : a European Journal of Chemical Biology. e202300551. PMID 37856284 DOI: 10.1002/cbic.202300551 |
0.395 |
|
| 2023 |
Zhou W, Ryan A, Janosko CP, Shoger KE, Haugh JM, Gottschalk RA, Deiters A. Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk. Rsc Chemical Biology. 4: 765-773. PMID 37799579 DOI: 10.1039/d2cb00157h |
0.381 |
|
| 2023 |
Rahman SMT, Haugh JM. On the inference of ERK signaling dynamics from protein biosensor measurements. Molecular Biology of the Cell. mbcE22100476. PMID 36884295 DOI: 10.1091/mbc.E22-10-0476 |
0.492 |
|
| 2022 |
Chandra A, Butler MT, Bear JE, Haugh JM. Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling. Biophysical Journal. 121: 102-118. PMID 34861242 DOI: 10.1016/j.bpj.2021.11.2889 |
0.395 |
|
| 2021 |
Baldwin SA, Van Bruggen SM, Koelbl JM, Appalabhotla R, Bear JE, Haugh JM. Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration. Biomicrofluidics. 15: 044101. PMID 34290842 DOI: 10.1063/5.0054764 |
0.335 |
|
| 2020 |
Rahman SMT, Zhou W, Deiters A, Haugh JM. Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. The Journal of Biological Chemistry. PMID 32371393 DOI: 10.1074/Jbc.Ra119.012079 |
0.495 |
|
| 2020 |
Nosbisch JL, Rahman A, Mohan K, Elston TC, Bear JE, Haugh JM. Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing. Plos Computational Biology. 16: e1007708. PMID 32255775 DOI: 10.1371/Journal.Pcbi.1007708 |
0.535 |
|
| 2019 |
Miller CJ, LaFosse PK, Asokan SB, Haugh JM, Bear JE, Elston TC. Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31365063 DOI: 10.1093/Intbio/Zyz023 |
0.392 |
|
| 2019 |
Tiruthani K, Mischler A, Ahmed S, Mahinthakumar J, Haugh JM, Rao BM. Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation. Science Signaling. 12. PMID 31164479 DOI: 10.1126/Scisignal.Aap7584 |
0.629 |
|
| 2017 |
Mohan K, Nosbisch JL, Elston TC, Bear JE, Haugh JM. A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis. Biophysical Journal. 113: 185-194. PMID 28700916 DOI: 10.1016/J.Bpj.2017.05.035 |
0.528 |
|
| 2017 |
Rahman A, Haugh JM. Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation. The Journal of Biological Chemistry. PMID 28069808 DOI: 10.1074/Jbc.M116.761205 |
0.489 |
|
| 2016 |
Johnson HE, Haugh JM. Are Filopodia Privileged Signaling Structures in Migrating Cells? Biophysical Journal. PMID 27712827 DOI: 10.1016/J.Bpj.2016.09.022 |
0.501 |
|
| 2016 |
Liu X, Asokan SB, Bear JE, Haugh JM. Quantitative analysis of B-lymphocyte migration directed by CXCL13. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27477203 DOI: 10.1039/C6Ib00128A |
0.37 |
|
| 2016 |
King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, et al. Lamellipodia are critical for haptotactic sensing and response. Journal of Cell Science. PMID 27173494 DOI: 10.1242/Jcs.184507 |
0.473 |
|
| 2015 |
Haynes EM, Asokan SB, King SJ, Johnson HE, Haugh JM, Bear JE. GMFβ controls branched actin content and lamellipodial retraction in fibroblasts. The Journal of Cell Biology. 209: 803-12. PMID 26101216 DOI: 10.1083/Jcb.201501094 |
0.409 |
|
| 2015 |
Liu X, Welf ES, Haugh JM. Linking morphodynamics and directional persistence of T lymphocyte migration. Journal of the Royal Society, Interface / the Royal Society. 12. PMID 25904526 DOI: 10.1098/Rsif.2014.1412 |
0.414 |
|
| 2015 |
Herring LE, Grant KG, Blackburn K, Haugh JM, Goshe MB. Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 988: 166-74. PMID 25777480 DOI: 10.1016/J.Jchromb.2015.02.017 |
0.499 |
|
| 2015 |
Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM. F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling. The Journal of Cell Biology. 208: 443-55. PMID 25666809 DOI: 10.1083/Jcb.201406102 |
0.504 |
|
| 2015 |
Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE. Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Developmental Cell. 32: 54-67. PMID 25543281 DOI: 10.1016/J.Devcel.2014.10.026 |
0.379 |
|
| 2014 |
Asokan SB, Johnson HE, Rahman A, King SJ, Rotty JD, Lebedeva IP, Haugh JM, Bear JE. Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway. Developmental Cell. 31: 747-60. PMID 25482883 DOI: 10.1016/J.Devcel.2014.10.024 |
0.534 |
|
| 2014 |
Rahman A, Haugh JM. Deactivation of a negative regulator: a distinct signal transduction mechanism, pronounced in Akt signaling. Biophysical Journal. 107: L29-32. PMID 25418317 DOI: 10.1016/J.Bpj.2014.10.003 |
0.512 |
|
| 2014 |
Vernekar VN, Wallace CS, Wu M, Chao JT, O'Connor SK, Raleigh A, Liu X, Haugh JM, Reichert WM. Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration. Colloids and Surfaces. B, Biointerfaces. 123: 225-35. PMID 25262410 DOI: 10.1016/J.Colsurfb.2014.09.020 |
0.367 |
|
| 2014 |
Bear JE, Haugh JM. Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Current Opinion in Cell Biology. 30: 74-82. PMID 24999834 DOI: 10.1016/J.Ceb.2014.06.005 |
0.507 |
|
| 2014 |
Ahmed S, Grant KG, Edwards LE, Rahman A, Cirit M, Goshe MB, Haugh JM. Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states. Molecular Systems Biology. 10: 718. PMID 24489118 DOI: 10.1002/Msb.134708 |
0.693 |
|
| 2013 |
Johnson HE, Haugh JM. Quantitative analysis of phosphoinositide 3-kinase (PI3K) signaling using live-cell total internal reflection fluorescence (TIRF) microscopy. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. 61: 14.14.1-14.14.24. PMID 24510804 DOI: 10.1002/0471143030.Cb1414S61 |
0.451 |
|
| 2013 |
Welf ES, Johnson HE, Haugh JM. Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility. Molecular Biology of the Cell. 24: 3945-55. PMID 24152734 DOI: 10.1091/Mbc.E13-06-0311 |
0.462 |
|
| 2013 |
Ott LE, Sung EJ, Melvin AT, Sheats MK, Haugh JM, Adler KB, Jones SL. Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein. Plos One. 8: e66512. PMID 23840497 DOI: 10.1371/Journal.Pone.0066512 |
0.716 |
|
| 2012 |
Cirit M, Grant KG, Haugh JM. Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132. Plos One. 7: e50975. PMID 23226437 DOI: 10.1371/Journal.Pone.0050975 |
0.49 |
|
| 2012 |
Haugh JM. Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring? Biophysical Journal. 102: 2003-11. PMID 22824263 DOI: 10.1016/J.Bpj.2012.03.055 |
0.362 |
|
| 2012 |
Haugh JM. Cell regulation: a time to signal, a time to respond. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 34: 528-9. PMID 22696110 DOI: 10.1002/Bies.201200077 |
0.557 |
|
| 2012 |
Welf ES, Haugh JM. Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics. Methods in Cell Biology. 110: 223-41. PMID 22482951 DOI: 10.1016/B978-0-12-388403-9.00009-6 |
0.507 |
|
| 2012 |
Welf ES, Ahmed S, Johnson HE, Melvin AT, Haugh JM. Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. The Journal of Cell Biology. 197: 105-14. PMID 22472441 DOI: 10.1083/Jcb.201108152 |
0.822 |
|
| 2012 |
Cirit M, Haugh JM. Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation. The Biochemical Journal. 441: 77-85. PMID 21943356 DOI: 10.1042/Bj20110833 |
0.559 |
|
| 2012 |
Welf ES, Haugh JM. Erratum to: Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells Cellular and Molecular Bioengineering. 5: 514-516. DOI: 10.1007/S12195-012-0252-9 |
0.308 |
|
| 2011 |
Cirit M, Haugh JM. Quantitative models of signal transduction networks: How detailed should they be? Communicative & Integrative Biology. 4: 353-6. PMID 21980579 DOI: 10.4161/Cib.4.3.15149 |
0.437 |
|
| 2011 |
Haugh JM. Cells see the light to bring signaling under control. Nature Methods. 8: 808-9. PMID 21959135 DOI: 10.1038/Nmeth.1708 |
0.432 |
|
| 2011 |
Chylek LA, Hu B, Blinov ML, Emonet T, Faeder JR, Goldstein B, Gutenkunst RN, Haugh JM, Lipniacki T, Posner RG, Yang J, Hlavacek WS. Guidelines for visualizing and annotating rule-based models. Molecular Biosystems. 7: 2779-95. PMID 21647530 DOI: 10.1039/C1Mb05077J |
0.348 |
|
| 2011 |
Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM. In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling. Biophysical Journal. 100: 1893-901. PMID 21504725 DOI: 10.1016/J.Bpj.2011.02.047 |
0.784 |
|
| 2011 |
Ahmed S, Yang HK, Ozcam AE, Efimenko K, Weiger MC, Genzer J, Haugh JM. Poly(vinylmethylsiloxane) elastomer networks as functional materials for cell adhesion and migration studies. Biomacromolecules. 12: 1265-71. PMID 21361274 DOI: 10.1021/Bm101549Y |
0.78 |
|
| 2011 |
Welf ES, Haugh JM. Signaling pathways that control cell migration: models and analysis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 231-40. PMID 21305705 DOI: 10.1002/Wsbm.110 |
0.534 |
|
| 2011 |
Buhrman G, Kumar VS, Cirit M, Haugh JM, Mattos C. Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. The Journal of Biological Chemistry. 286: 3323-31. PMID 21098031 DOI: 10.1074/Jbc.M110.193854 |
0.4 |
|
| 2010 |
Cirit M, Wang CC, Haugh JM. Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network. The Journal of Biological Chemistry. 285: 36736-44. PMID 20847054 DOI: 10.1074/Jbc.M110.148759 |
0.781 |
|
| 2010 |
Welf ES, Haugh JM. Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells. Cellular and Molecular Bioengineering. 3: 30-39. PMID 20473365 DOI: 10.1007/S12195-010-0100-8 |
0.569 |
|
| 2010 |
Cirit M, Krajcovic M, Choi CK, Welf ES, Horwitz AF, Haugh JM. Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells. Plos Computational Biology. 6: e1000688. PMID 20195494 DOI: 10.1371/Journal.Pcbi.1000688 |
0.465 |
|
| 2010 |
Weiger MC, Ahmed S, Welf ES, Haugh JM. Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling. Biophysical Journal. 98: 67-75. PMID 20085720 DOI: 10.1016/J.Bpj.2009.09.051 |
0.817 |
|
| 2009 |
Haugh JM. Analysis of reaction-diffusion systems with anomalous subdiffusion. Biophysical Journal. 97: 435-42. PMID 19619457 DOI: 10.1016/J.Bpj.2009.05.014 |
0.326 |
|
| 2009 |
Barua D, Faeder JR, Haugh JM. A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases. Plos Computational Biology. 5: e1000364. PMID 19381268 DOI: 10.1371/Journal.Pcbi.1000364 |
0.77 |
|
| 2009 |
Wang CC, Cirit M, Haugh JM. PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk. Molecular Systems Biology. 5: 246. PMID 19225459 DOI: 10.1038/Msb.2009.4 |
0.756 |
|
| 2009 |
Weiger MC, Wang CC, Krajcovic M, Melvin AT, Rhoden JJ, Haugh JM. Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. Journal of Cell Science. 122: 313-23. PMID 19126672 DOI: 10.1242/Jcs.037564 |
0.782 |
|
| 2008 |
Comfort KK, Haugh JM. Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper TH2 Cell Line. Cellular and Molecular Bioengineering. 1. PMID 24255693 DOI: 10.1007/S12195-008-0015-9 |
0.735 |
|
| 2008 |
Monine MI, Haugh JM. Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties. Cell Adhesion & Migration. 2: 137-46. PMID 19262100 DOI: 10.4161/Cam.2.2.6511 |
0.534 |
|
| 2008 |
Monine MI, Haugh JM. Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk. Biophysical Journal. 95: 2172-82. PMID 18502802 DOI: 10.1529/Biophysj.108.128892 |
0.48 |
|
| 2008 |
Haugh JM. Biophysics: cells get in shape for a crawl. Nature. 453: 461-2. PMID 18497809 DOI: 10.1038/453461A |
0.352 |
|
| 2008 |
Barua D, Faeder JR, Haugh JM. Computational models of tandem SRC homology 2 domain interactions and application to phosphoinositide 3-kinase. The Journal of Biological Chemistry. 283: 7338-45. PMID 18204097 DOI: 10.1074/Jbc.M708359200 |
0.736 |
|
| 2008 |
Haugh JM, Weiger MC. Computational Methods and Modeling: Modeling Intracellular Signal Transduction Processes Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 3: 1061-1081. DOI: 10.1002/9783527619375.ch17b |
0.775 |
|
| 2007 |
Haugh JM. Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology. Biophysical Journal. 92: L93-5. PMID 17416624 DOI: 10.1529/Biophysj.107.105213 |
0.515 |
|
| 2007 |
Barua D, Faeder JR, Haugh JM. Structure-based kinetic models of modular signaling protein function: focus on Shp2. Biophysical Journal. 92: 2290-300. PMID 17208977 DOI: 10.1529/Biophysj.106.093484 |
0.773 |
|
| 2006 |
Schneider IC, Haugh JM. Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation. Cell Cycle (Georgetown, Tex.). 5: 1130-4. PMID 16760661 DOI: 10.4161/Cc.5.11.2770 |
0.751 |
|
| 2006 |
Haugh JM. Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing. Biophysical Journal. 90: 2297-308. PMID 16415056 DOI: 10.1529/Biophysj.105.077610 |
0.502 |
|
| 2006 |
Kaur H, Park CS, Lewis JM, Haugh JM. Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly. The Biochemical Journal. 393: 235-43. PMID 16159314 DOI: 10.1042/Bj20051022 |
0.421 |
|
| 2006 |
Haugh JM, Schneider IC. Effectiveness factor for spatial gradient sensing in living cells Chemical Engineering Science. 61: 5603-5611. DOI: 10.1016/J.Ces.2006.04.041 |
0.714 |
|
| 2005 |
Schneider IC, Haugh JM. Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. The Journal of Cell Biology. 171: 883-92. PMID 16314431 DOI: 10.1083/Jcb.200509028 |
0.794 |
|
| 2005 |
Monine MI, Haugh JM. Reactions on cell membranes: comparison of continuum theory and Brownian dynamics simulations. The Journal of Chemical Physics. 123: 074908. PMID 16229621 DOI: 10.1063/1.2000236 |
0.365 |
|
| 2005 |
Schneider IC, Parrish EM, Haugh JM. Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological Polarity. Biophysical Journal. 89: 1420-30. PMID 15923219 DOI: 10.1529/Biophysj.105.061218 |
0.78 |
|
| 2004 |
Haugh JM. Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists. Biotechnology Progress. 20: 1337-44. PMID 15458315 DOI: 10.1021/Bp0499101 |
0.438 |
|
| 2004 |
Haugh JM, Schneider IC, Lewis JM. On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling. Journal of Theoretical Biology. 230: 119-32. PMID 15276005 DOI: 10.1016/J.Jtbi.2004.04.023 |
0.758 |
|
| 2004 |
Schneider IC, Haugh JM. Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. Biophysical Journal. 86: 599-608. PMID 14695304 DOI: 10.1016/S0006-3495(04)74138-7 |
0.744 |
|
| 2004 |
Haugh JM, Schneider IC. Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups. Biophysical Journal. 86: 589-98. PMID 14695303 DOI: 10.1016/S0006-3495(04)74137-5 |
0.757 |
|
| 2003 |
Park CS, Schneider IC, Haugh JM. Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts. The Journal of Biological Chemistry. 278: 37064-72. PMID 12871957 DOI: 10.1074/Jbc.M304968200 |
0.758 |
|
| 2002 |
Haugh JM. Localization of receptor-mediated signal transduction pathways: the inside story. Molecular Interventions. 2: 292-307. PMID 14993384 DOI: 10.1124/Mi.2.5.292 |
0.488 |
|
| 2002 |
Haugh JM, Meyer T. Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling. Journal of Cell Science. 115: 303-10. PMID 11839782 |
0.404 |
|
| 2002 |
Haugh JM. A unified model for signal transduction reactions in cellular membranes. Biophysical Journal. 82: 591-604. PMID 11806904 DOI: 10.1016/S0006-3495(02)75424-6 |
0.402 |
|
| 2000 |
Haugh JM, Codazzi F, Teruel M, Meyer T. Spatial sensing in fibroblasts mediated by 3' phosphoinositides. The Journal of Cell Biology. 151: 1269-80. PMID 11121441 DOI: 10.1083/Jcb.151.6.1269 |
0.448 |
|
| 2000 |
Haugh JM, Wells A, Lauffenburger DA. Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. Biotechnology and Bioengineering. 70: 225-38. PMID 10972934 DOI: 10.1002/1097-0290(20001020)70:2<225::Aid-Bit12>3.0.Co;2-S |
0.649 |
|
| 1999 |
Haugh JM, Huang AC, Wiley HS, Wells A, Lauffenburger DA. Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts. The Journal of Biological Chemistry. 274: 34350-60. PMID 10567412 DOI: 10.1074/Jbc.274.48.34350 |
0.629 |
|
| 1999 |
Haugh JM, Schooler K, Wells A, Wiley HS, Lauffenburger DA. Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway. The Journal of Biological Chemistry. 274: 8958-65. PMID 10085141 DOI: 10.1074/Jbc.274.13.8958 |
0.642 |
|
| 1998 |
Haugh JM, Lauffenburger DA. Analysis of receptor internalization as a mechanism for modulating signal transduction. Journal of Theoretical Biology. 195: 187-218. PMID 9822563 DOI: 10.1006/Jtbi.1998.0791 |
0.665 |
|
| 1998 |
Lauffenburger DA, Fallon EM, Haugh JM. Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics. Chemistry & Biology. 5: R257-63. PMID 9818145 DOI: 10.1016/S1074-5521(98)90110-7 |
0.566 |
|
| 1997 |
Haugh JM, Lauffenburger DA. Physical modulation of intracellular signaling processes by locational regulation. Biophysical Journal. 72: 2014-31. PMID 9129805 DOI: 10.1016/S0006-3495(97)78846-5 |
0.654 |
|
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